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Aliases for FBLN7 Gene

Aliases for FBLN7 Gene

  • Fibulin 7 2 3
  • TM14 3 4 6
  • FIBL-7 3 4
  • Fibulin-7 3

External Ids for FBLN7 Gene

Summaries for FBLN7 Gene

GeneCards Summary for FBLN7 Gene

FBLN7 (Fibulin 7) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and heparin binding.

UniProtKB/Swiss-Prot for FBLN7 Gene

  • An adhesion molecule that interacts with extracellular matrix molecules in developing teeth and may play important roles in differentiation and maintenance of odontoblasts as well as in dentin formation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBLN7 Gene

Genomics for FBLN7 Gene

Genomic Location for FBLN7 Gene

Start:
112,138,385 bp from pter
End:
112,188,216 bp from pter
Size:
49,832 bases
Orientation:
Plus strand

Genomic View for FBLN7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBLN7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBLN7 Gene

Regulatory Elements for FBLN7 Gene

Proteins for FBLN7 Gene

  • Protein details for FBLN7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53RD9-FBLN7_HUMAN
    Recommended name:
    Fibulin-7
    Protein Accession:
    Q53RD9
    Secondary Accessions:
    • A0JNV1
    • A0JNV2
    • Q5H9P5
    • Q8N9G0

    Protein attributes for FBLN7 Gene

    Size:
    439 amino acids
    Molecular mass:
    47376 Da
    Quaternary structure:
    • Interacts with heparin, FBLN1, FN1 and DSPP. Preferentially binds dental mesenchyme cells and odontoblasts but not dental epithelial cells or nondental cells. Binding requires a heparan sulfate-containing receptor on the cell surface as well as an integrin (By similarity).

    Alternative splice isoforms for FBLN7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBLN7 Gene

Proteomics data for FBLN7 Gene at MOPED

Post-translational modifications for FBLN7 Gene

Other Protein References for FBLN7 Gene

No data available for DME Specific Peptides for FBLN7 Gene

Domains for FBLN7 Gene

Gene Families for FBLN7 Gene

HGNC:

UniProtKB/Swiss-Prot:

FBLN7_HUMAN
Domain:
  • Contains 3 EGF-like domains.:
    • Q53RD9
  • Contains 1 Sushi (CCP/SCR) domain.:
    • Q53RD9
Family:
  • Belongs to the fibulin family.:
    • Q53RD9
genes like me logo Genes that share domains with FBLN7: view

Function for FBLN7 Gene

Molecular function for FBLN7 Gene

UniProtKB/Swiss-Prot Function: An adhesion molecule that interacts with extracellular matrix molecules in developing teeth and may play important roles in differentiation and maintenance of odontoblasts as well as in dentin formation.

Gene Ontology (GO) - Molecular Function for FBLN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with FBLN7: view

Phenotypes for FBLN7 Gene

genes like me logo Genes that share phenotypes with FBLN7: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FBLN7 Gene

Localization for FBLN7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBLN7 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBLN7 Gene COMPARTMENTS Subcellular localization image for FBLN7 gene
Compartment Confidence
extracellular 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FBLN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005925 focal adhesion IDA 21423176
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FBLN7: view

Pathways for FBLN7 Gene

SuperPathways for FBLN7 Gene

No Data Available

Interacting Proteins for FBLN7 Gene

Gene Ontology (GO) - Biological Process for FBLN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with FBLN7: view

No data available for Pathways by source for FBLN7 Gene

Transcripts for FBLN7 Gene

Unigene Clusters for FBLN7 Gene

Fibulin 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBLN7 Gene

No ASD Table

Relevant External Links for FBLN7 Gene

GeneLoc Exon Structure for
FBLN7
ECgene alternative splicing isoforms for
FBLN7

Expression for FBLN7 Gene

mRNA expression in normal human tissues for FBLN7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FBLN7 Gene

SOURCE GeneReport for Unigene cluster for FBLN7 Gene Hs.437696

genes like me logo Genes that share expressions with FBLN7: view

Orthologs for FBLN7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBLN7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBLN7 36
  • 99.16 (n)
  • 98.41 (a)
FBLN7 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBLN7 36
  • 89.52 (n)
  • 90.89 (a)
FBLN7 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBLN7 36
  • 88.84 (n)
  • 88.84 (a)
FBLN7 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbln7 36
  • 86.33 (n)
  • 84.97 (a)
Fbln7 16
Fbln7 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBLN7 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 80 (a)
OneToMany
-- 37
  • 64 (a)
OneToMany
-- 37
  • 65 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fbln7 36
  • 86.07 (n)
  • 84.93 (a)
chicken
(Gallus gallus)
Aves FBLN7 36
  • 71.58 (n)
  • 67.7 (a)
FBLN7 37
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBLN7 37
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbln7 36
  • 67.27 (n)
  • 69.7 (a)
zebrafish
(Danio rerio)
Actinopterygii FBLN7 37
  • 63 (a)
OneToOne
LOC100000083 36
  • 65.54 (n)
  • 66.11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3758 37
  • 35 (a)
OneToOne
Species with no ortholog for FBLN7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBLN7 Gene

ENSEMBL:
Gene Tree for FBLN7 (if available)
TreeFam:
Gene Tree for FBLN7 (if available)

Paralogs for FBLN7 Gene

Selected SIMAP similar genes for FBLN7 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FBLN7: view

No data available for Paralogs for FBLN7 Gene

Variants for FBLN7 Gene

Sequence variations from dbSNP and Humsavar for FBLN7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1316488 -- 112,151,566(-) GCTCC(A/G)TGGTG intron-variant
rs1320359 -- 112,162,766(-) CAGTA(A/T)CTGGC intron-variant
rs1320360 -- 112,159,525(-) GACAG(C/G)CCCAA intron-variant
rs1574447 -- 112,150,037(+) ATTGG(C/T)GGTGA intron-variant
rs2312460 -- 112,178,269(+) AAAAA(A/C)CAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBLN7 Gene

Variant ID Type Subtype PubMed ID
nsv521956 CNV Loss 19592680
nsv874863 CNV Loss 21882294
dgv4278n71 CNV Gain 21882294
esv22302 CNV Loss 19812545
esv2720527 CNV Deletion 23290073
esv1152452 CNV Deletion 17803354
esv1437076 CNV Deletion 17803354
nsv874866 CNV Loss 21882294
esv2720529 CNV Deletion 23290073
nsv874867 CNV Loss 21882294

Relevant External Links for FBLN7 Gene

HapMap Linkage Disequilibrium report
FBLN7
Human Gene Mutation Database (HGMD)
FBLN7

Disorders for FBLN7 Gene

Relevant External Links for FBLN7

Genetic Association Database (GAD)
FBLN7
genes like me logo Genes that share disorders with FBLN7: view

No data available for UniProtKB/Swiss-Prot for FBLN7 Gene

Publications for FBLN7 Gene

  1. TM14 is a new member of the fibulin family (fibulin-7) that interacts with extracellular matrix molecules and is active for cell binding. (PMID: 17699513) de Vega S. … Yamada Y. (J. Biol. Chem. 2007) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Anti-Ro/SSA autoantibody-mediated regulation of extracellular matrix fibulins in human epithelial cells of the salivary gland. (PMID: 19229767) Lisi S. … Sisto M. (Scand. J. Rheumatol. 2009) 3

Products for FBLN7 Gene

Sources for FBLN7 Gene

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