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Aliases for FBLN7 Gene

Aliases for FBLN7 Gene

  • Fibulin 7 2 3 5
  • FIBL-7 3 4
  • TM14 3 4

External Ids for FBLN7 Gene

Previous GeneCards Identifiers for FBLN7 Gene

  • GC02P112613
  • GC02P112895
  • GC02P105408
  • GC02P112182
  • GC02P112183

Summaries for FBLN7 Gene

GeneCards Summary for FBLN7 Gene

FBLN7 (Fibulin 7) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and heparin binding.

UniProtKB/Swiss-Prot for FBLN7 Gene

  • An adhesion molecule that interacts with extracellular matrix molecules in developing teeth and may play important roles in differentiation and maintenance of odontoblasts as well as in dentin formation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBLN7 Gene

Genomics for FBLN7 Gene

Regulatory Elements for FBLN7 Gene

Promoters for FBLN7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBLN7 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBLN7 Gene

112,138,385 bp from pter
112,188,218 bp from pter
49,834 bases
Plus strand

Genomic View for FBLN7 Gene

Genes around FBLN7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBLN7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBLN7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBLN7 Gene

Proteins for FBLN7 Gene

  • Protein details for FBLN7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A0JNV1
    • A0JNV2
    • Q5H9P5
    • Q8N9G0

    Protein attributes for FBLN7 Gene

    439 amino acids
    Molecular mass:
    47376 Da
    Quaternary structure:
    • Interacts with heparin, FBLN1, FN1 and DSPP. Preferentially binds dental mesenchyme cells and odontoblasts but not dental epithelial cells or nondental cells. Binding requires a heparan sulfate-containing receptor on the cell surface as well as an integrin (By similarity).

    Alternative splice isoforms for FBLN7 Gene


neXtProt entry for FBLN7 Gene

Proteomics data for FBLN7 Gene at MOPED

Post-translational modifications for FBLN7 Gene

Other Protein References for FBLN7 Gene

No data available for DME Specific Peptides for FBLN7 Gene

Domains & Families for FBLN7 Gene

Gene Families for FBLN7 Gene

Suggested Antigen Peptide Sequences for FBLN7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 EGF-like domains.
  • Belongs to the fibulin family.
  • Contains 3 EGF-like domains.
  • Contains 1 Sushi (CCP/SCR) domain.
  • Belongs to the fibulin family.
genes like me logo Genes that share domains with FBLN7: view

Function for FBLN7 Gene

Molecular function for FBLN7 Gene

UniProtKB/Swiss-Prot Function:
An adhesion molecule that interacts with extracellular matrix molecules in developing teeth and may play important roles in differentiation and maintenance of odontoblasts as well as in dentin formation.

Gene Ontology (GO) - Molecular Function for FBLN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with FBLN7: view
genes like me logo Genes that share phenotypes with FBLN7: view

Animal Model Products

miRNA for FBLN7 Gene

miRTarBase miRNAs that target FBLN7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBLN7 Gene

Localization for FBLN7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBLN7 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for FBLN7 Gene COMPARTMENTS Subcellular localization image for FBLN7 gene
Compartment Confidence
extracellular 5
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for FBLN7 Gene

Pathways & Interactions for FBLN7 Gene

SuperPathways for FBLN7 Gene

No Data Available

Interacting Proteins for FBLN7 Gene

Gene Ontology (GO) - Biological Process for FBLN7 Gene


No data available for Pathways by source and SIGNOR curated interactions for FBLN7 Gene

Drugs & Compounds for FBLN7 Gene

No Compound Related Data Available

Transcripts for FBLN7 Gene

Unigene Clusters for FBLN7 Gene

Fibulin 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBLN7 Gene

No ASD Table

Relevant External Links for FBLN7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBLN7 Gene

mRNA expression in normal human tissues for FBLN7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBLN7 Gene

This gene is overexpressed in Urine (24.9), Bone marrow mesenchymal stem cell (10.3), and Pancreas (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBLN7 Gene

SOURCE GeneReport for Unigene cluster for FBLN7 Gene Hs.437696

genes like me logo Genes that share expression patterns with FBLN7: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FBLN7 Gene

Orthologs for FBLN7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBLN7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FBLN7 35
  • 89.52 (n)
  • 90.89 (a)
FBLN7 36
  • 89 (a)
(Canis familiaris)
Mammalia FBLN7 35
  • 88.84 (n)
  • 88.84 (a)
FBLN7 36
  • 86 (a)
(Mus musculus)
Mammalia Fbln7 35
  • 86.33 (n)
  • 84.97 (a)
Fbln7 16
Fbln7 36
  • 85 (a)
(Pan troglodytes)
Mammalia FBLN7 35
  • 99.16 (n)
  • 98.41 (a)
FBLN7 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Fbln7 35
  • 86.07 (n)
  • 84.93 (a)
(Monodelphis domestica)
Mammalia FBLN7 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 80 (a)
-- 36
  • 64 (a)
-- 36
  • 65 (a)
(Gallus gallus)
Aves FBLN7 35
  • 71.58 (n)
  • 67.7 (a)
FBLN7 36
  • 42 (a)
(Anolis carolinensis)
Reptilia FBLN7 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbln7 35
  • 67.27 (n)
  • 69.7 (a)
(Danio rerio)
Actinopterygii LOC100000083 35
  • 65.54 (n)
  • 66.11 (a)
FBLN7 36
  • 63 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3758 36
  • 35 (a)
Species with no ortholog for FBLN7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBLN7 Gene

Gene Tree for FBLN7 (if available)
Gene Tree for FBLN7 (if available)

Paralogs for FBLN7 Gene

(10) SIMAP similar genes for FBLN7 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FBLN7: view

No data available for Paralogs for FBLN7 Gene

Variants for FBLN7 Gene

Sequence variations from dbSNP and Humsavar for FBLN7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs35586251 - 112,165,120(+) GCAGC(A/G)TGGTG reference, missense
rs1316488 -- 112,151,566(-) GCTCC(A/G)TGGTG intron-variant
rs1320359 -- 112,162,766(-) CAGTA(A/T)CTGGC intron-variant
rs1320360 -- 112,159,525(-) GACAG(C/G)CCCAA intron-variant
rs1574447 -- 112,150,037(+) ATTGG(C/T)GGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBLN7 Gene

Variant ID Type Subtype PubMed ID
nsv521956 CNV Loss 19592680
nsv874863 CNV Loss 21882294
dgv4278n71 CNV Gain 21882294
esv22302 CNV Loss 19812545
esv2720527 CNV Deletion 23290073
esv1152452 CNV Deletion 17803354
esv1437076 CNV Deletion 17803354
nsv874866 CNV Loss 21882294
esv2720529 CNV Deletion 23290073
nsv874867 CNV Loss 21882294

Variation tolerance for FBLN7 Gene

Residual Variation Intolerance Score: 63.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.22; 62.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBLN7 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBLN7 Gene

Disorders for FBLN7 Gene

Relevant External Links for FBLN7

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FBLN7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBLN7 Gene

Publications for FBLN7 Gene

  1. TM14 is a new member of the fibulin family (fibulin-7) that interacts with extracellular matrix molecules and is active for cell binding. (PMID: 17699513) de Vega S. … Yamada Y. (J. Biol. Chem. 2007) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A C-terminal fragment of fibulin-7 interacts with endothelial cells and inhibits their tube formation in culture. (PMID: 24480309) de Vega S. … Yamada Y. (Arch. Biochem. Biophys. 2014) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for I^-Pix in negative regulation of focal adhesion maturation. (PMID: 21423176) Kuo J.C. … Waterman C.M. (Nat. Cell Biol. 2011) 3

Products for FBLN7 Gene

Sources for FBLN7 Gene

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