Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FBLN5 Gene

protein-coding GIFtS: 66
GCID: GC14M092335

fibulin 5

Explore 27 diseases affiliated with
FBLN5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Fibulin 5¹ ²		Urine P50 Protein² ³
DANCE¹ ² ³		FIBL-5² ³
UP50¹ ² ³		ADCL2²
ARMD3¹ ² ⁵		ARCL1A²
EVEC¹ ²		Fibulin-5¹
Developmental Arteries And Neural Crest EGF-Like Protein² ³		Dance³

External Ids:	HGNC: 3602¹	Entrez Gene: 10516²	Ensembl: ENSG00000140092⁷	OMIM: 604580⁵	UniProtKB: Q9UBX5³

Export aliases for FBLN5 gene to outside databases

Previous GC identifers: GC14M089841 GC14M086151 GC14M090325 GC14M091405 GC14M072518

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FBLN5:

The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and

calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the

RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is

reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and

endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling.

Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I),

and age-related macular degeneration type 3 (ARMD3). (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FBLN5_HUMAN, Q9UBX5

Function: Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a

vascular ligand for integrin receptors and may play a role in vascular development and remodeling

Gene Wiki entry for FBLN5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FBLN5 gene promoter:
E2F-4 E2F-3a E2F-5 AP-1 ATF-2 E2F-2 AREB6 E2F E2F-1 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FBLN5 promoter sequence

Search SABiosciences Chromatin IP Primers for FBLN5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBLN5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.1 Ensembl cytogenetic band: 14q32.12 HGNC cytogenetic band: 14q31

FBLN5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBLN5 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M092335: view genomic region (about GC identifiers)

Start:	92,335,755 bp from pter	End:	92,414,331 bp from pter
Size:	78,577 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FBLN5_HUMAN, Q9UBX5 (See protein sequence)

Recommended Name: Fibulin-5 precursor

Size: 448 amino acids; 50180 Da

Subunit: Homodimer

Subcellular location: Secreted

Secondary accessions: O75966 Q6IAL4 Q6UWA3

Explore the universe of human proteins at neXtProt for FBLN5: NX_Q9UBX5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UBX5

FBLN5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006320.2

ENSEMBL proteins:

ENSP00000267620 ENSP00000345008 ENSP00000451982 ENSP00000450719 ENSP00000451002

ENSP00000451486 ENSP00000450787

Reactome Protein details: Q9UBX5
Human Recombinant Protein Products for FBLN5:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for FBLN5 (Fibulin 5/DANCE)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: FBLN5 OriGene Protein Over-expression Lysate: FBLN5 OriGene Custom Protein Services for FBLN5
	GenScript Custom Purified and Recombinant Proteins Services for FBLN5
	Novus Biologicals FBLN5 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for FBLN5

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	TAS	10428823
GO:0005615	extracellular space	IDA	--
GO:0005625	soluble fraction	--	--
GO:0005737	cytoplasm	IDA	--
GO:0016020	membrane	--	--

FBLN5 for ontologies About GeneDecksing

FBLN5 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of FBLN5
	R&D Systems Antibodies for FBLN5 (Fibulin 5/DANCE)
	OriGene Antibodies (see all 2): FBLN5 OriGene Custom Antibody Services for FBLN5
	GenScript Custom Superior Antibodies Services for FBLN5
	Novus Biologicals FBLN5 Antibodies
	Abcam antibodies for FBLN5
	Uscn Antibodies for FBLN5
	ThermoFisher Antibodies for FBLN5

Assay Products for FBLN5:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FBLN5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FBLN5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FBLN5 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR000742 EG-like_dom

IPR026823 cEGF

IPR000152 EGF-type_Asp/Asn_hydroxyl_site

IPR018097 EGF_Ca-bd_CS

IPR001881 EGF-like_Ca-bd

Graphical View of Domain Structure for InterPro Entry Q9UBX5

ProtoNet protein and cluster: Q9UBX5

2 Blocks protein families:

IPB000152 Aspartic acid and asparagine hydroxylation site

IPB001881 EGF-like calcium-binding

UniProtKB/Swiss-Prot: FBLN5_HUMAN, Q9UBX5

Similarity: Belongs to the fibulin family

Similarity: Contains 6 EGF-like domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: FBLN5_HUMAN, Q9UBX5

Function: Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a

vascular ligand for integrin receptors and may play a role in vascular development and remodeling

Genatlas biochemistry entry for FBLN5:

fibulin 5,calcium binding,expressed and up-regulated in the developing and disease adult arterial vasculature

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004888	transmembrane signaling receptor activity	--	--
GO:0005178	integrin binding	TAS	10428823
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	19570982
GO:0008022	protein C-terminus binding	IPI	15528465

FBLN5 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for FBLN5:

Decreased viability with pacli

Increased gamma-H2AX phosphory

8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Fbln5):

cardiovascular system	cellular	craniofacial	homeostasis/metabolism	integument
muscle	respiratory system	tumorigenesis

FBLN5 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FBLN5

miRNA Products:		OriGene 3'-UTR Clone: FBLN5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FBLN5
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate FBLN5 (see all 12):
		hsa-miR-3671 hsa-miR-4291 hsa-miR-922 hsa-miR-3614-3p hsa-miR-513a-5p hsa-miR-27a hsa-miR-128 hsa-miR-3681*

		SwitchGear 3'UTR luciferase reporter plasmid: FBLN5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FBLN5 (see all 7) OriGene shRNA RFP: FBLN5 OriGene siRNA: FBLN5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBLN5
		Sirion Biotech Custom design and validation of potent shRNA sequences against FBLN5

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for FBLN5
			Sirion Biotech Customized adenovirus for overexpression of FBLN5 Sirion Biotech Customized adenovirus for potent knockdown of FBLN5

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBLN5 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBLN5 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FBLN5 (NM_006329)
		Sino Biological Human cDNA Clone for FBLN5
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBLN5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBLN5

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FBLN5
		LifeMap BioReagents: cell line associated with FBLN5: PureStem ES-210, Ecto-ntu Progenitor
		Sirion Biotech Customized stable knockdown cell line services for FBLN5 Sirion Biotech Customized inducible knockdown cell line services for FBLN5 Sirion Biotech Customized stable overexpressing cell line services for FBLN5 Sirion Biotech Customized inducible overexpressing cell line services for FBLN5

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBLN5

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Elastic fibre formation

Elastic fibre formation

1.00

Molecules associated with elastic fibres

0.84

Collagen formation

Extracellular matrix organization

0.54

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Reactome Pathways for FBLN5

	Molecules associated with elastic fibres
	Extracellular matrix organization
	Elastic fibre formation

FBLN5 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FBLN5

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/19 Interacting proteins for FBLN5 (Q9UBX5^{1, 2, 3} ENSP00000345008⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LTBP2	Q14767²^,³, ENSP00000261978⁴	MINT-5115605 MINT-5115583 I2D: score=2 STRING: ENSP00000261978
GFI1B	Q5VTD9²^,³, ENSP00000344782⁴	MINT-2868452 I2D: score=3 STRING: ENSP00000344782
ATN1	P54259²^,³, ENSP00000349076⁴	MINT-2868433 MINT-2868414 I2D: score=3 STRING: ENSP00000349076
LOXL1	Q08397³, ENSP00000261921⁴	I2D: score=2 STRING: ENSP00000261921
LPA	P08519³, ENSP00000321334⁴	I2D: score=1 STRING: ENSP00000321334

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001558	regulation of cell growth	IEA	--
GO:0007160	cell-matrix adhesion	TAS	10428823
GO:0007596	blood coagulation	--	--
GO:0030198	extracellular matrix organization	--	--
GO:0034394	protein localization to cell surface	ISS	--

FBLN5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FBLN5 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FBLN5
1 Novoseek chemical compound relationship for FBLN5 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
vegf	0	3	15231070 (3)

Search CenterWatch for drugs/clinical trials and news about FBLN5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FBLN5 gene:

NM_006329.3

Unigene Cluster for FBLN5:

Fibulin 5

Hs.332708 [show with all ESTs]

Unigene Representative Sequence: BX537531

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000556961(uc001xzw.3) ENST00000267620(uc010aud.3 uc001xzx.4 uc010aue.3)

ENST00000342058 ENST00000556154 ENST00000554121 ENST00000557088 ENST00000557462

ENST00000554468 ENST00000557570

miRNA Products:		OriGene 3'-UTR Clone: FBLN5 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FBLN5
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate FBLN5 (see all 12):
		hsa-miR-3671 hsa-miR-4291 hsa-miR-922 hsa-miR-3614-3p hsa-miR-513a-5p hsa-miR-27a hsa-miR-128 hsa-miR-3681*

		SwitchGear 3'UTR luciferase reporter plasmid: FBLN5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FBLN5 (see all 7) OriGene shRNA RFP: FBLN5 OriGene siRNA: FBLN5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBLN5
		Sirion Biotech Custom design and validation of potent shRNA sequences against FBLN5

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBLN5 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBLN5 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FBLN5 (NM_006329)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBLN5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBLN5

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBLN5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FBLN5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBLN5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBLN5

Additional cDNA sequence:

AF093118.1 AF112152.1 AJ133490.1 AK074540.1 AK075147.1 AK094032.1 AK125600.1 AK307592.1

AL110148.1 AY358898.1 BC022280.1 BX248290.1 BX537531.1 CR457140.1

22 DOTS entries:

DT.101956801 DT.448201 DT.97838719 DT.100833145 DT.100811307 DT.100678061 DT.100811302 DT.120761189

DT.95278027 DT.99971149 DT.100026316 DT.120761247 DT.95278026 DT.120761239 DT.120761224 DT.120761227

DT.120761234 DT.100708071 DT.100835411 DT.120761213 DT.40294682 DT.120761238

24/316 AceView cDNA sequences (see all 316):

BM544363 BM970136 NM_006329 BQ723059 BQ716569 BC022280 AA385728 BX641994

AK075147 AA605252 AI656035 AI796573 AI834283 CA397139 AA298909 BP377490

CD172152 BM666348 AI086653 CR604352 BQ772930 F08964 AI215116 AW183044

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for FBLN5 (see all 14) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	·	2d	·	2e	·	2f	·	2g	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	·	9c	·	9d	^	10a	·	10b	^	11a	·	11b	^
SP1:																			-				-		-						-		-		-
SP2:																			-				-		-						-		-
SP3:																			-				-		-										-
SP4:																							-		-						-		-		-
SP5:																																			-

ExUns:	12a	·	12b	^	13	^	14	^	15	^	16	^	17	^	18a	·	18b
SP1:									-				-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for FBLN5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FBLN5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTATGTTCTG

About this image

FBLN5 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/17 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 17)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Cartilage

Cervical Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Selective marker (cell-identifying gene)

Cartilage

Lumbar Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Sacral Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Thoracic Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Head Mesenchyme

Branchial Arch 1

Cranial Neural Crest Cells

Neural Crest

Ovary

Skeletal Muscle

Mandibular Arch Muscles

Myoblasts

Skeletal Muscle

Bone

Rostral Endochondral Facial Bones

Bone

Rostral Skull Membranous Bones

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/12 LifeMap Cells (see all 12)

Name

Category

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Trophoblast-like cells (Generation of tropho...)

Definitive endoderm-like cells (A scalable, suspensi...)

HyStem+TGF?3+GDF5-induced SK11 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

HyStem+TGF?3+GDF5-induced SM30 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

HyStem+TGF?3+GDF5-induced 7SMOO32 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

TGF?3+BMP7-induced chondrocytes (Chondrogenic HyStem+...)

Bone, Cartilage

HyStem+TGF?3+GDF5-induced 7PEND24 cells (HyStem+TGF?3+GDF5 in...)

Bone

HyStem+TGF?3+GDF5-induced 4D20.8 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

See FBLN5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FBLN5

SOURCE GeneReport for Unigene cluster: Hs.332708

UniProtKB/Swiss-Prot: FBLN5_HUMAN, Q9UBX5

Tissue specificity: Expressed predominantly in heart, ovary, and colon but also in kidney, pancreas, testis, lung and

placenta. Not detectable in brain, liver, thymus, prostate, or peripheral blood leukocytes

SABiosciences Custom PCR Arrays for FBLN5

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBLN5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FBLN5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBLN5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBLN5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBLN5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FBLN5 gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FBLN5¹	fibulin 5	77.7(n) 84.91(a)		423413 XM_421323.1 XP_421323.1
lizard (Anolis carolinensis)	Reptilia	FBLN5⁶	--	80(a)	1 ↔ 1	1(11738683-11792694)
zebrafish (Danio rerio)	Actinopterygii	fbln5¹	fibulin 5	64.78(n) 65.61(a)		449806 NM_001005979.1 NP_001005979.1
fruit fly (Drosophila melanogaster)	Insecta	frac⁶	faulty attraction	7(a)	1 → many	3L(7555710-7562599)
worm (Caenorhabditis elegans)	Secernentea	mup-4⁶ mua-3⁶	Transmembrane cell adhesion receptor mua-3	4(a) 2(a)	possible ortholog possible ortholog	III(7479616-7489010) III(10160599-10183440)

ENSEMBL Gene Tree for FBLN5 (if available)
TreeFam Gene Tree for FBLN5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FBLN5 gene

FBN1² LTBP3² SCUBE3² FBN3² FBN2² LTBP4² EFEMP1² SCUBE1²

EFEMP2² LTBP2² LTBP1² FBLN2² FBLN1² SCUBE2²

18/28 SIMAP similar genes for FBLN5 using alignment to 7 protein entries: FBLN5_HUMAN (see all proteins) (see all similar genes):

SNRPF COQ5 KIAA1651 pp12301 SH2B3 NCKAP1L

MBP1 GEMIN6 PFKFB3 EFEMP2 FCER1G GATC

PROS1 EFEMP1 C12orf76 MST132 ATF1 TUBA1C

FBLN5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1802492^1,2	C	non-pathogenic	79292399(-)	`CCGCTG/TACATC`	2	D Y	mis¹		2		NA	4
rs80338765^1,2	C	pathogenic	79278851(-)	`AGGATA/GGAAGG`	2	R G	mis¹		0	--	--	--	--
rs28939370^1,2	C	pathogenic	79282833(-)	`ACGGCC/TCTTTC`	2	P S	mis¹		0	--	--	--	--
rs28939073^1,2	C	pathogenic	79292360(-)	`TGTACC/TGGGAC`	2	R W	mis¹		1		NA	4552
rs75680283^1,2	F	--	72516075(+)	`TCAAAA/GATCCT`	1	--	ds500¹		1		NA	120
rs76642980^1,2		--	72516087(+)	`ATGGCC/TGGGCC`	1	--	ds500¹		0	--	--	--	--
rs10197^1,2	H	--	72516675(+)	`CTTTCG/AAAGGA`	1	--	ut3¹ ese³		6		MN NS EA NA	598
rs77357345^1,2	F	--	72516699(+)	`TTTTTT/AAAAAA`	1	--	ut3¹		1		WA	118
rs17804735^1,2	C,F,H	--	72516808(+)	`CATTCT/CCTAAA`	1	--	ut3¹		8		NA NS EA	678
rs17731705^1,2	C	--	72516899(+)	`CCGCCA/GGCTCC`	1	--	ut3¹		3		NA	136

HapMap Linkage Disequilibrium report for FBLN5 (92335755 - 92414331 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FBLN5: --
Human Gene Mutation Database (HGMD): FBLN5

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBLN5

DNA2.0 Custom Variant and Variant Library Synthesis for FBLN5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FBLN5 for disorders           About GeneDecksing

OMIM gene information: 604580
OMIM disorders: 219100  123700  608895
UniProtKB/Swiss-Prot: FBLN5_HUMAN, Q9UBX5

Defects in FBLN5 are the cause of cutis laxa, autosomal dominant, type 2 (ADCL2) [MIM:614434]. A connective

tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a

premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. Additional variable

clinical features are gastrointestinal diverticula, hernia, and genital prolapse. Rare manifestations are pulmonary

artery stenosis, aortic aneurysm, bronchiectasis, and emphysema

Defects in FBLN5 are a cause of cutis laxa, autosomal recessive, type 1A (ARCL1A) [MIM:219100]. A connective

tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a

premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. The clinical spectrum

of autosomal recessive cutis laxa is highly heterogeneous with respect to organ involvement and severity. Type I

autosomal recessive cutis laxa is a specific, life-threatening disorder with organ involvement, lung atelectasis and

emphysema, diverticula of the gastrointestinal and genitourinary systems, and vascular anomalies. Associated cranial

anomalies, late closure of the fontanel, joint laxity, hip dislocation, and inguinal hernia have been observed but are

uncommon

Defects in FBLN5 are the cause of age-related macular degeneration type 3 (ARMD3) [MIM:608895]. ARMD is a

multifactorial disease and the most common cause of irreversible vision loss in the developed world. In most patients,

the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid (known as drusen)

that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane

20/27 diseases for FBLN5 (see all 27): About MalaCards

cutis laxa age related macular degeneration macular degeneration cutis laxa, autosomal dominant

lymph node tuberculosis contractural arachnodactyly supravalvular aortic stenosis connective tissue disease

costello syndrome portal hypertension aortic aneurysm scoliosis

keloids alopecia vaginitis tuberculosis

hypertension ovarian carcinoma periodontitis pharyngitis

2 diseases from the University of Copenhagen DISEASES database for FBLN5:

Cutis laxa Age related macular degeneration

4 Novoseek disease relationships for FBLN5 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cutis laxa	92.6	31	12189163 (4), 17035250 (4), 16652333 (3), 12618961 (2) (see all 12)
drusen	64.3	2	17109857 (1), 16652333 (1)
aortic stenosis supravalvular	62.4	1	16893474 (1)
connective tissue diseases	57.1	1	16893474 (1)

GeneTests: FBLN5

FBLN5-Related Cutis Laxa

Genetic Association Database (GAD): FBLN5
Human Genome Epidemiology (HuGE) Navigator: FBLN5 (8 documents)

Export disorders for FBLN5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FBLN5 gene, integrated from 9 sources (see all 101):
(articles sorted by number of sources associating them with FBLN5)

Utopia: connect your pdf to the dynamic
world of online information

Missense variations in the fibulin 5 gene and age-related macular degeneration. (PubMed id 15269314)^{1, 2, 4} Stone E.M.... Sheffield V.C. (2004)
DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon-injured arteries. (PubMed id 10428823)^{1, 2, 9} Nakamura T.... Honjo T. (1999)
Homozygosity for a missense mutation in fibulin-5 (FBLN5) results in a severe form of cutis laxa. (PubMed id 12189163)^{1, 2, 9} Loeys B.... de Paepe A. (2002)
Fibulin 5 forms a compact dimer in physiological solu tions. (PubMed id 19617354)^{1, 2, 9} Jones R.P....Trump D. (2009)
Genetic heterogeneity of cutis laxa: a heterozygous tandem duplication within the fibulin-5 (FBLN5) gene. (PubMed id 12618961)^{1, 2, 9} Markova D.... Chu M.-L. (2003)
Assignment of fibulin-5 (FBLN5) to human chromosome 14q31 by in situ hybridization and radiation hybrid mapping. (PubMed id 10640802)^{1, 3, 9} Kowal R.C....Schultz R.A. (1999)
Homozygous missense mutation in fibulin-5 in an Iranian autosomal recessive cutis laxa pedigree and associated haplotype. (PubMed id 16691202)^{1, 2, 9} Elahi E.... Loeys B. (2006)
Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)^{1, 2} Otsuki T....Isogai T. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10516	HGNC: 3602	AceView: FBLN5	Ensembl:ENSG00000140092	euGenes: HUgn10516
ECgene: FBLN5	H-InvDB: FBLN5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FBLN5	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/FBLN5

Intellectual Property for FBLN5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FBLN5 gene:
Search GeneIP for patents involving FBLN5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

	EMD Millipore Mono- and Polyclonal Antibodies for the study of FBLN5
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for FBLN5 (Fibulin 5/DANCE)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for FBLN5 (Fibulin 5/DANCE)

	OriGene Antibodies for FBLN5		OriGene shRNA RFP for FBLN5
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FBLN5		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBLN5
	OriGene Protein Over-expression Lysate for FBLN5		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for FBLN5		OriGene 3'-UTR Clone for FBLN5
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBLN5		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBLN5
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for FBLN5		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for FBLN5		OriGene Custom Protein Services for FBLN5
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FBLN5
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBLN5
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBLN5
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBLN5
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBLN5
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBLN5

	GenScript Custom Purified and Recombinant Proteins Services for FBLN5		GenScript cDNA clones with any tag delivered in your preferred vector for FBLN5
	GenScript Custom Assay Services for FBLN5		GenScript Custom Superior Antibodies Services for FBLN5
	GenScript Custom overexpressing Cell Line Services for FBLN5		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in FBLN5 promoter
	Search Chromatin IP Primers for FBLN5
	RT² qPCR Primer Assay in human, mouse, rat FBLN5
	GNC Network for FBLN5
	SABiosciences Custom PCR Arrays for FBLN5

Search Tocris compounds for FBLN5

	Browse Sino Biological Proteins and Antibodies
	cDNA Clones for FBLN5
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	FBLN5 antibodies
	FBLN5 lysates

	Antibodies for FBLN5
	See all of Abcam's Antibodies, Kits and Proteins for FBLN5
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

FBLN5 Proteins, Antibodies, CLIAs, and ELISAs

Cell Line associated with FBLN5: PureStem ES-210, Ecto-ntu Progenitor

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBLN5

	SwitchGear 3'UTR luciferase reporter plasmids for FBLN5
	SwitchGear Promoter luciferase reporter plasmids for FBLN5

ThermoFisher Antibodies for FBLN5

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBLN5

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FBLN5

Sirion Biotech Customized:

	stable knockdown cell line services for FBLN5
	inducible knockdown cell line services for FBLN5
	design and validation of potent shRNA sequences against FBLN5
	adenovirus for potent knockdown of FBLN5
	adenovirus for overexpression of FBLN5
	stable overexpressing cell line services for FBLN5
	inducible overexpressing cell line services for FBLN5

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes FBLN5 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

FBLN5 Gene

fibulin 5

Aliases
for FBLN5 gene

Summaries
for FBLN5 gene

Genomic Views
for FBLN5 gene

Proteins
for FBLN5 gene

Protein Domains /
Families
for FBLN5 gene

Function
for FBLN5 gene

Pathways & Interactions
for FBLN5 gene

Drugs & Compounds
for FBLN5 gene

Transcripts
for FBLN5 gene

Expression
for FBLN5 gene

Orthologs
for FBLN5 gene

Paralogs
for FBLN5 gene

Genomic Variants
for FBLN5 gene

Disorders / Diseases
for FBLN5 gene

Publications
for FBLN5 gene

External Searches for FBLN5 gene

Genome Databases showing FBLN5 gene

Other Databases showing FBLN5 gene

Specialized Databases showing FBLN5 gene

Intellectual Property
for FBLN5 gene

Products
for FBLN5 gene

View Random Gene

Advanced Search

Export list of displayed genes

FBLN5 Gene

fibulin 5

Aliasesfor FBLN5 gene

Summariesfor FBLN5 gene

Genomic Viewsfor FBLN5 gene

Proteinsfor FBLN5 gene

Protein Domains /Familiesfor FBLN5 gene

Functionfor FBLN5 gene

Pathways & Interactionsfor FBLN5 gene

Drugs & Compoundsfor FBLN5 gene

Transcriptsfor FBLN5 gene

Expression for FBLN5 gene

Orthologsfor FBLN5 gene

Paralogsfor FBLN5 gene

Genomic Variantsfor FBLN5 gene

Disorders / Diseasesfor FBLN5 gene

Publicationsfor FBLN5 gene

External Searches for FBLN5 gene

Genome Databases showing FBLN5 gene

Other Databases showing FBLN5 gene

Specialized Databases showing FBLN5 gene

Intellectual Propertyfor FBLN5 gene

Productsfor FBLN5 gene

View Random Gene

Aliases
for FBLN5 gene

Summaries
for FBLN5 gene

Genomic Views
for FBLN5 gene

Proteins
for FBLN5 gene

Protein Domains /
Families
for FBLN5 gene

Function
for FBLN5 gene

Pathways & Interactions
for FBLN5 gene

Drugs & Compounds
for FBLN5 gene

Transcripts
for FBLN5 gene

Expression
for FBLN5 gene

Orthologs
for FBLN5 gene

Paralogs
for FBLN5 gene

Genomic Variants
for FBLN5 gene

Disorders / Diseases
for FBLN5 gene

Publications
for FBLN5 gene

Intellectual Property
for FBLN5 gene

Products
for FBLN5 gene