Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FBLN2 Gene

protein-coding   GIFtS: 68
GCID: GC03P013565

Fibulin 2

  See FBLN2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Fibulin 21 2
FIBL-22 3
fibulin-22

External Ids:    HGNC: 36011   Entrez Gene: 21992   Ensembl: ENSG000001635207   OMIM: 1358215   UniProtKB: P980953   

Export aliases for FBLN2 gene to outside databases

Previous GC identifer: GC03P013541


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FBLN2 Gene:
This gene encodes an extracellular matrix protein, which belongs to the fibulin family. This protein binds various
extracellular ligands and calcium. It may play a role during organ development, in particular, during the
differentiation of heart, skeletal and neuronal structures. Alternatively spliced transcript variants encoding
different isoforms have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for FBLN2 Gene:
FBLN2 (fibulin 2) is a protein-coding gene. Diseases associated with FBLN2 include osteochondritis dissecans, and familial osteochondritis dissecans. GO annotations related to this gene include extracellular matrix binding and calcium ion binding. An important paralog of this gene is LTBP3.

UniProtKB/Swiss-Prot: FBLN2_HUMAN, P98095
Function: Its binding to fibronectin and some other ligands is calcium dependent

Gene Wiki entry for FBLN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBLN2 gene promoter:
         ER-alpha   AML1a   HSF1 (long)   GATA-1   AREB6   Ik-2   deltaCREB   HOXA5   HSF1short   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBLN2 promoter sequence
   Search Chromatin IP Primers for FBLN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBLN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.1   Ensembl cytogenetic band:  3p25.1   HGNC cytogenetic band: 3p25-p24

FBLN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBLN2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P013565:  view genomic region     (about GC identifiers)

Start:
13,573,824 bp from pter      End:
13,679,922 bp from pter
Size:
106,099 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FBLN2_HUMAN, P98095 (See protein sequence)
Recommended Name: Fibulin-2 precursor  
Size: 1184 amino acids; 126573 Da
Subunit: Homotrimer; disulfide-linked. Interacts with LAMA2 (By similarity)
Developmental stage: Widely expressed during embryonic development. Primarily detected within the neuropithelium,
spinal ganglia and peripheral nerves
Secondary accessions: B7Z9C5 Q8IUI0 Q8IUI1
Alternative splicing: 2 isoforms:  P98095-1   P98095-2   

Explore the universe of human proteins at neXtProt for FBLN2: NX_P98095

Explore proteomics data for FBLN2 at MOPED

Post-translational modifications: 

  • O-glycosylated with core 1 or possibly core 8 glycans. It is unsure if the O-glycosylation is on Thr-347 or
    Ser-3481
  • Glycosylation2 at Asn180, Thr347, Ser348, Thr357, Ser361, Thr370, Asn507, Asn1035
  • Modification sites at PhosphoSitePlus

  • See FBLN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001004019.1  NP_001158507.1  NP_001989.2  

    ENSEMBL proteins: 
     ENSP00000384169   ENSP00000295760   ENSP00000420164   ENSP00000420042   ENSP00000295761  
     ENSP00000399224   ENSP00000445705  
    Reactome Protein details: P98095

    FBLN2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FBLN2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for FBLN2
    GenScript Custom Purified and Recombinant Proteins Services for FBLN2
    Novus Biologicals FBLN2 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBLN2

     
    Search eBioscience for Proteins for FBLN2 

     
    antibodies-online proteins for FBLN2 (10 products) 

     
    Search antibodies-online for peptides for FBLN2

    FBLN2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for FBLN2
    OriGene Custom Antibody Services for FBLN2
    Novus Biologicals FBLN2 Antibodies
    Abcam antibodies for FBLN2
    Cloud-Clone Corp. Antibodies for FBLN2
    ThermoFisher Antibodies for FBLN2
    antibodies-online antibodies for FBLN2 (41 products) 

    FBLN2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FBLN2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FBLN2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FBLN2
    Cloud-Clone Corp. CLIAs for FBLN2
    Search eBioscience for ELISAs for FBLN2 
    antibodies-online kits for FBLN2 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    FBLN: Fibulins

    Selected InterPro protein domains (see all 8):
     IPR000742 EG-like_dom
     IPR026823 cEGF
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR018097 EGF_Ca-bd_CS
     IPR001881 EGF-like_Ca-bd_dom

    Graphical View of Domain Structure for InterPro Entry P98095

    ProtoNet protein and cluster: P98095

    2 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB001881 EGF-like calcium-binding


    UniProtKB/Swiss-Prot: FBLN2_HUMAN, P98095
    Similarity: Belongs to the fibulin family
    Similarity: Contains 3 anaphylatoxin-like domains
    Similarity: Contains 10 EGF-like domains


    Find genes that share domains with FBLN2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBLN2_HUMAN, P98095
    Function: Its binding to fibronectin and some other ligands is calcium dependent

         Genatlas biochemistry entry for FBLN2:
    fibulin 2,calcium binding,extracellular matrix protein,expressed in heart tissue,located in the embryonic
    endocardial cushion tissue and predominantly in the valves,also expressed in skin,perichondrium,elastic intima of
    blood vessels and kidney glomerulus and colocalizing with FBN1 in these tissues with different variants

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent TAS7806230
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
    GO:0050840extracellular matrix binding IEA--
         
    Find genes that share ontologies with FBLN2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FBLN2:
     Cell cycle / mitosis defect 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Fbln2):
     cardiovascular system 

    Find genes that share phenotypes with FBLN2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fbln2tm1Chu for FBLN2

       genOway: Develop your customized and physiologically relevant rodent model for FBLN2

    miRNA
    Products:
        
    miRTarBase miRNAs that target FBLN2:
    hsa-mir-335-5p (MIRT018315), hsa-mir-1 (MIRT002753)

    Block miRNA regulation of human, mouse, rat FBLN2 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate FBLN2:
    hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-545 hsa-miR-4323 hsa-miR-3662 hsa-miR-32* hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidFBLN2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FBLN2
    Predesigned siRNA for gene silencing in human, mouse, rat FBLN2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FBLN2

    Clone
    Products:
         
    OriGene clones in human, mouse for FBLN2 (see all 17)
    OriGene ORF clones in mouse, rat for FBLN2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): FBLN2 (NM_001004019)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBLN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBLN2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FBLN2
    ESI BIO PureStem Progenitor for FBLN2: 
    PureStem E15, Meso-prx/latp Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBLN2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FBLN2_HUMAN, P98095: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0031012colocalizes with extracellular matrix ISS--

    Find genes that share ontologies with FBLN2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FBLN2 About    
    See pathways by source

    SuperPathContained pathways About
    1Elastic fibre formation
    Elastic fibre formation0.73
    Molecules associated with elastic fibres0.73
    2Degradation of the extracellular matrix
    Extracellular matrix organization0.34
    3Cell adhesion Cell matrix glycoconjugates
    Cell adhesion Cell matrix glycoconjugates


    Find genes that share SuperPaths with FBLN2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for FBLN2
        Cell adhesion Cell-matrix glycoconjugates

    1 Reactome Pathway for FBLN2
        Molecules associated with elastic fibres


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FBLN2
    Interactions:

        GeneGlobe Interaction Network for FBLN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for FBLN2 (P980952, 3 ENSP000003841694) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATN1P542592, 3, ENSP000003490764MINT-2858818 I2D: score=3 STRING: ENSP00000349076
    FN1P027513, ENSP000003468394I2D: score=3 STRING: ENSP00000346839
    LAMA5O152303, ENSP000002529994I2D: score=3 STRING: ENSP00000252999
    NID1P145433, ENSP000002641874I2D: score=3 STRING: ENSP00000264187
    LAMA1P253913, ENSP000003743094I2D: score=2 STRING: ENSP00000374309
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010811positive regulation of cell-substrate adhesion IEA--
    GO:0030198extracellular matrix organization TAS--

    Find genes that share ontologies with FBLN2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FBLN2

    1 HMDB Compound for FBLN2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    4 Novoseek inferred chemical compound relationships for FBLN2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurocan 68.5 1 11038354 (1)
    heparin 34.3 6 9431988 (1), 10934193 (1), 11733994 (1), 10092882 (1) (see all 6)
    calcium 5.63 3 8737292 (1), 9299350 (1), 8245130 (1)
    fibrinogen 2.85 1 7543056 (1)



    Find genes that share compounds with FBLN2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FBLN2 gene (3 alternative transcripts): 
    NM_001004019.1  NM_001165035.1  NM_001998.2  

    Unigene Cluster for FBLN2:

    Fibulin 2
    Hs.198862  [show with all ESTs]
    Unigene Representative Sequence: NM_001165035
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000404922(uc011ava.2 uc011avb.2 uc011avc.2) ENST00000295760(uc011auz.2)
    ENST00000465610 ENST00000492059 ENST00000477845 ENST00000295761 ENST00000421373
    ENST00000535798
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FBLN2 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate FBLN2:
    hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-545 hsa-miR-4323 hsa-miR-3662 hsa-miR-32* hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidFBLN2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FBLN2
    Predesigned siRNA for gene silencing in human, mouse, rat FBLN2
    Clone
    Products:
         
    OriGene clones in human, mouse for FBLN2 (see all 17)
    OriGene ORF clones in mouse, rat for FBLN2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): FBLN2 (NM_001004019)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBLN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBLN2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FBLN2
    OriGene qSTAR qPCR primer pairs in human, mouse for FBLN2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBLN2
      QuantiTect SYBR Green Assays in human, mouse, rat FBLN2
      QuantiFast Probe-based Assays in human, mouse, rat FBLN2

    Additional mRNA sequence: 

    AK129883.1 AK300913.1 AK304777.1 AK304827.1 AL050095.1 AL080171.1 AY130459.1 BC051690.1 
    X82494.1 

    6 DOTS entries:

    DT.91905714  DT.454137  DT.100654133  DT.100792594  DT.120883977  DT.100703619 

    Selected AceView cDNA sequences (see all 208):

    BU553983 BU556734 BM784974 BU855098 BU859521 AI193253 BM673717 BU846307 
    BU556575 NM_001998 AI354814 BM746486 AI246349 BU553532 CR624008 NM_001004019 
    BU844464 AA451985 BU931668 BG012914 CD515030 BU855789 BG680961 BP344809 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FBLN2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
    SP1:                                -                                                                                             
    SP2:                                -                                   -                                                         
    SP3:                                                                                                                              
    SP4:                                                                                                                              


    ECgene alternative splicing isoforms for FBLN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FBLN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACATTATAA
    FBLN2 Expression
    About this image


    FBLN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 5 entries
             Subepicardial Cells Epicardium
             Coronary Vessels
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Mesenchymal Condensate Cells Stylopod
             Endochondral Facial Bones
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             mK3
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Stylopod
             Stylopod
     
     Epithelial Cells
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    FBLN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBLN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.198862

    UniProtKB/Swiss-Prot: FBLN2_HUMAN, P98095
    Tissue specificity: Component of both basement membranes and other connective tissues. Expressed in heart,
    placenta and ovary

        Custom PCR Arrays for FBLN2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FBLN2
    OriGene qSTAR qPCR primer pairs in human, mouse for FBLN2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBLN2
    QuantiTect SYBR Green Assays in human, mouse, rat FBLN2
    QuantiFast Probe-based Assays in human, mouse, rat FBLN2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBLN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for FBLN2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbln21 , 5 fibulin 21, 5 81.55(n)1
    82.4(a)1
      6 (40.42 cM)5
    141151  NM_007992.21  NP_032018.21 
     912124555 
    chicken
    (Gallus gallus)
    Aves FBLN21 fibulin 2 69.28(n)
    69.39(a)
      427583  XM_425156.4  XP_425156.4 
    lizard
    (Anolis carolinensis)
    Reptilia FBLN26
    fibulin 2
    55(a)
    1 ↔ 1
    GL343225.1(167222-375803)
    zebrafish
    (Danio rerio)
    Actinopterygii fbln21 fibulin 2 60.06(n)
    55.67(a)
      553503  XM_001341241.2  XP_001341277.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG319991 CG31999 43.98(n)
    36.4(a)
      43777  NM_166745.3  NP_726551.2 
    worm
    (Caenorhabditis elegans)
    Secernentea B0393.53 EGF-like aspartic acid and asparagine
    hydroxylation more
    36(a)   III(4840866-4847880)   --


    ENSEMBL Gene Tree for FBLN2 (if available)
    TreeFam Gene Tree for FBLN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FBLN2 gene
    LTBP32  HMCN12  SCUBE32  FBLN52  MEGF62  EFEMP12  LTBP42  SCUBE12  
    EFEMP22  LTBP22  HMCN22  LTBP12  FBLN12  SCUBE22  
    Selected SIMAP similar genes for FBLN2 using alignment to 7 protein entries:     FBLN2_HUMAN (see all proteins) (see all similar genes):
    DKFZp586A1519    LTBP1    LDLR    PROS1    NELL1    EFEMP2
    FBN2    FBN3    MBP1    LTBP3    LTBP2    UMOD
    SCUBE2    FBLN1    MATN2    EFEMP1    HMCN1    MEGF6

    Find genes that share paralogs with FBLN2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FBLN2 (see all 2260)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1850297261,2
    --13588649(+) TCTATA/CACCCC 2 -- us2k10--------
    rs98199171,2
    C,H--13588698(+) CAATCT/CGTCAT 2 -- us2k15Minor allele frequency- C:0.00NS EA CSA 422
    rs1118530481,2
    F--13588734(+) CTCCCT/GTGGGT 2 -- us2k11Minor allele frequency- G:0.03NS 496
    rs792512891,2
    F--13588799(+) TTTTTT/CGAATT 2 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1114568161,2
    C,F--13588826(+) TGGTAC/TACACC 2 -- us2k12Minor allele frequency- T:0.02NS WA 630
    rs778799351,2
    C--13588862(+) CAGGCA/GATCAT 2 -- us2k13Minor allele frequency- G:0.17NA NS 634
    rs1886863481,2
    --13588894(+) AGTATG/TCAATG 2 -- us2k10--------
    rs1138243601,2
    F--13588969(+) CGTAGG/CCTAGT 2 -- us2k11Minor allele frequency- C:0.01NS 514
    rs1112818021,2
    C,F--13588971(+) TAGGCT/CAGTAA 2 -- us2k11Minor allele frequency- C:0.01NS 514
    rs1130312861,2
    C,F--13589133(+) CTTTCG/AGTTTG 2 -- us2k12Minor allele frequency- A:0.02NS WA 636

    HapMap Linkage Disequilibrium report for FBLN2 (13573824 - 13679922 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FBLN2 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1004545CNV Deletion20482838
    esv2724942CNV Deletion23290073
    esv1004489CNV Deletion20482838
    nsv3708CNV Insertion18451855
    nsv3707CNV Insertion18451855
    nsv526900CNV Loss19592680
    nsv876550CNV Loss21882294
    nsv876567CNV Loss21882294
    nsv876552CNV Loss21882294
    nsv470416CNV Loss18288195

    Human Gene Mutation Database (HGMD): FBLN2
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing FBLN2
    DNA2.0 Custom Variant and Variant Library Synthesis for FBLN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 135821    OMIM disorders: --

    2 diseases for FBLN2:    
    About MalaCards
    osteochondritis dissecans    familial osteochondritis dissecans


    Find genes that share disorders with FBLN2           About GenesLikeMe

    2 Novoseek inferred disease relationships for FBLN2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    solar elastosis 69 3 11531782 (3)
    tumors 0 1 8245130 (1)

    Genetic Association Database (GAD): FBLN2
    Human Genome Epidemiology (HuGE) Navigator: FBLN2 (3 documents)

    Export disorders for FBLN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FBLN2 gene, integrated from 10 sources (see all 81):
    (articles sorted by number of sources associating them with FBLN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fibulin-2 (FBLN2): human cDNA sequence, mRNA expression, and mapping of the gene on human and mouse chromosomes. (PubMed id 7806230)1, 2, 3, 9 Zhang R.-Z....Chu M.-L. (Genomics 1994)
    2. The extracellular matrix proteins fibulin-1 and fibulin-2 in the early human embryo. (PubMed id 8737292)1, 2, 9 Miosge N.... Herken R. (Histochem. J. 1996)
    3. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    4. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Association of extracellular matrix proteins fibulin-1 and fibulin-2 with fibronectin in bone marrow stroma. (PubMed id 10848816)1, 9 Gu Y.C....Ekblom M. (Br. J. Haematol. 2000)
    7. Confocal laser scanning analysis of the association of fibulin-2 with fibrillin-1 and fibronectin define different stages of skin regeneration. (PubMed id 9886271)1, 9 Raghunath M....Timpl R. (J. Invest. Dermatol. 1999)
    8. Structure and expression of fibulin-2, a novel extracellular matrix protein with multiple EGF-like repeats and consensus motifs for calcium binding. (PubMed id 8245130)1, 9 Pan T.C....Chu M.L. (J. Cell Biol. 1993)
    9. Increased deposition of fibulin-2 in solar elastosis and its colocalization with elastic fibres. (PubMed id 11531782)1, 9 Hunzelmann N....Krieg T. (Br. J. Dermatol. 2001)
    10. Fibrillin-1 and fibulin-2 interact and are colocalized in some tissues. (PubMed id 8702639)1, 9 Reinhardt D.P....Sakai L.Y. (J. Biol. Chem. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2199 HGNC: 3601 AceView: FBLN2 Ensembl:ENSG00000163520 euGenes: HUgn2199
    ECgene: FBLN2 H-InvDB: FBLN2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FBLN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FBLN2 gene:
    Search GeneIP for patents involving FBLN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for FBLN2   OriGene RNAi products in human, mouse, rat for FBLN2  
     OriGene qPCR primer pairs and template standards for FBLN2   OriGene Protein Over-expression Lysate for FBLN2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FBLN2  
     OriGene qSTAR qPCR primer pairs in human, mouse for FBLN2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FBLN2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FBLN2   OriGene Custom Protein Services for FBLN2  

     
     
     Block miRNA regulation of human, mouse, rat FBLN2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FBLN2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBLN2 Predesigned siRNA for gene silencing in human, mouse, rat FBLN2
     QuantiFast Probe-based Assays in human, mouse, rat FBLN2 QuantiTect SYBR Green Assays in human, mouse, rat FBLN2
     Custom PCR Arrays for FBLN2 Search Chromatin IP Primers for FBLN2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBLN2  GeneGlobe Interaction Network for FBLN2
     Regulatory tfbs in FBLN2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for FBLN2 GenScript cDNA clones with any tag delivered in your preferred vector for FBLN2
     GenScript Custom Assay Services for FBLN2 GenScript Custom overexpressing Cell Line Services for FBLN2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FBLN2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FBLN2 antibodies
     FBLN2 proteins
     Antibodies for FBLN2
     See all of Abcam's Antibodies, Kits and Proteins for FBLN2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for FBLN2
     Antibodies for FBLN2
     ELISAs for FBLN2
     CLIAs for FBLN2



     PureStem Progenitor for FBLN2: PureStem E15, Meso-prx/latp Progenitor
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBLN2
     SwitchGear 3'UTR luciferase reporter plasmids for FBLN2
     SwitchGear Promoter luciferase reporter plasmids for FBLN2
     ThermoFisher Antibodies for FBLN2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBLN2
     Browse compounds at ApexBio
     Search Addgene for plasmids for FBLN2
      Search eBioscience for proteins for FBLN2
      Search eBioscience for elisas for FBLN2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for FBLN2
     antibodies-online antibodies for FBLN2 (41 products)
     antibodies-online kits for FBLN2 (6 products)
      Search antibodies-online for peptides for FBLN2
     antibodies-online proteins for FBLN2 (10 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FBLN2 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4