Aliases for FBLN1 Gene
External Ids for FBLN1 Gene
- HGNC: 3600
- Entrez Gene: 2192
- Ensembl: ENSG00000077942
- OMIM: 135820
- UniProtKB: P23142
Previous GeneCards Identifiers for FBLN1 Gene
- GC22P042534
- GC22P044175
- GC22P044219
- GC22P045898
- GC22P028859
Summaries for FBLN1 Gene
-
Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3' end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants. [provided by RefSeq, Jul 2008]
GeneCards Summary for FBLN1 Gene
FBLN1 (Fibulin 1) is a Protein Coding gene. Diseases associated with FBLN1 include Synpolydactyly, 3/3'4, Associated With Metacarpal And Metatarsal Synostoses and Fbln1-Related Developmental Delay-Central Nervous System Anomaly-Syndactyly Syndrome. Among its related pathways are Elastic fibre formation and Degradation of the extracellular matrix. GO annotations related to this gene include calcium ion binding and peptidase activator activity. An important paralog of this gene is FBLN2.
UniProtKB/Swiss-Prot for FBLN1 Gene
-
Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBLN1 Gene
Genomics for FBLN1 Gene
Regulatory Elements for FBLN1 Gene
Enhancers for FBLN1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH22G045476 | 1 | Ensembl ENCODE | 12.3 | -24.3 | -24293 | 2.4 | FOXA2 SAP130 ZMYM3 CEBPG ZIC2 THRB RFX5 TEAD3 ZNF664 ZFHX2 | FBLN1 ENSG00000273243 PKDREJ GC22P045497 ENSG00000232363 |
| GH22G045528 | 0.9 | ENCODE dbSUPER | 12.9 | +27.5 | 27528 | 2.1 | SCRT1 GLIS2 ZFHX2 BHLHE40 ZNF10 FOS ZNF423 EGR2 | FBLN1 GC22P045526 GC22M045550 |
| GH22G045527 | 0.8 | ENCODE dbSUPER | 12.9 | +25.8 | 25848 | 0.5 | ZKSCAN8 ZNF341 ZNF10 ZIC2 | FBLN1 GC22P045526 GC22M045550 |
| GH22G045475 | 0.6 | ENCODE | 12.3 | -26.3 | -26318 | 1.4 | GLIS2 PRDM6 CEBPA CEBPB CEBPG MYC | FBLN1 GC22P045497 ENSG00000232363 |
| GH22G045449 | 1.5 | FANTOM5 Ensembl ENCODE dbSUPER | 4.9 | -49.2 | -49222 | 6.3 | FEZF1 ZIC2 ZNF664 FOS MIER1 GFI1B CEBPB REST MIER2 ZEB2 | LINC01589 RIBC2 FBLN1 TTC38 ENSG00000232363 GC22P045497 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FBLN1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FBLN1 gene promoter:
Regulatory Element Products
Genomic Location for FBLN1 Gene
- Chromosome:
- 22
- Start:
- 45,502,238 bp from pter
- End:
- 45,601,135 bp from pter
- Size:
- 98,898 bases
- Orientation:
- Plus strand
Genomic View for FBLN1 Gene
Genes around FBLN1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q13.31 by Ensembl
- 22q13.31 by Entrez Gene
- 22q13.31 by HGNC
FBLN1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBLN1 Gene
Proteins for FBLN1 Gene
-
Protein details for FBLN1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P23142-FBLN1_HUMAN
- Recommended name:
- Fibulin-1
- Protein Accession:
- P23142
- B0QY42
- B1AHL4
- P23143
- P23144
- P37888
- Q5TIC4
- Q8TBH8
- Q9HBQ5
- Q9UC21
- Q9UGR4
- Q9UH41
Protein attributes for FBLN1 Gene
- Size:
- 703 amino acids
- Molecular mass:
- 77214 Da
- Quaternary structure:
-
- Homomultimerizes and interacts with various extracellular matrix components such as FN1, LAMA1, LAMA2, NID, ACAN, CSPG2 and type IV collagen. Interacts also with APP, NOV, FGB and HPV type 16, HPV type 18, HPV type 31 and BPV type 1 E6 proteins. Interacts with FBLN7 (By similarity).
- SequenceCaution:
-
- Sequence=AAG17241.1; Type=Frameshift; Positions=116, 619, 639; Evidence={ECO:0000305};
Protein Expression for FBLN1 Gene
Post-translational modifications for FBLN1 Gene
Other Protein References for FBLN1 Gene
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for FBLN1
-
Custom Antibody ServicesOriGene Antibodies for FBLN1
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-
Cloud-Clone Corp. Antibodies for FBLN1
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- antibodies-online Antibodies for FBLN1: See all 89
- GeneTex FBLN1 antibody for FBLN1
-
Santa Cruz Biotechnology (SCBT) Antibodies for FBLN1
Protein Products
- R&D Systems Proteins and Enzymes for FBLN1 (Fibulin 1)
-
OriGene Purified Proteins for FBLN1
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-
Cloud-Clone Corp. Proteins for FBLN1
- antibodies-online Proteins for FBLN1: See all 16
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FBLN1
Assay Products
- antibodies-online Kits for FBLN1: See all 15
No data available for DME Specific Peptides for FBLN1 Gene
Domains & Families for FBLN1 Gene
Gene Families for FBLN1 Gene
- HGNC:
Protein Domains for FBLN1 Gene
Suggested Antigen Peptide Sequences for FBLN1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P23142- Family:
-
- Belongs to the fibulin family.
Function for FBLN1 Gene
Molecular function for FBLN1 Gene
- GENATLAS Biochemistry:
- fibulin 1,calcium binding,extracellular matrix protein (90-100kDa),prominently expressed in endocardium during development
- UniProtKB/Swiss-Prot Function:
- Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP.
- UniProtKB/Swiss-Prot Induction:
- Expression increased by estrogen in ovarian cancer cells.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001968 | fibronectin binding | IPI | 1400330 |
| GO:0005201 | extracellular matrix structural constituent | IDA | 2269669 |
| GO:0005509 | calcium ion binding | IEA,IDA | 9278415 |
| GO:0008022 | protein C-terminus binding | IPI | 11238726 |
| GO:0016504 | peptidase activator activity | IEA | -- |
Phenotypes for FBLN1 Gene
- MGI mutant phenotypes for FBLN1:
-
inferred from 2 alleles
- mortality/aging
- growth/size/body region phenotype
- immune system phenotype
- nervous system phenotype
- cardiovascular system phenotype
- respiratory system phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- integument phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- embryo phenotype
- hematopoietic system phenotype
- renal/urinary system phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for FBLN1:
-
- Increased vaccinia virus (VACV) infection
- Lamellipodia cells
- Decreased viability with carboplatin
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability of wild-type and TP53 knockout cells
- Decreased viability with paclitaxel
Animal Models for FBLN1 Gene
- MGI Knock Outs for FBLN1:
-
- Fbln1 tm1Tmpl
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FBLN1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FBLN1 gene
- Search ViGene Biosciences for FBLN1
CRISPR Products
-
OriGene CRISPR knockouts for FBLN1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBLN1
- GenScript: Design CRISPR guide RNA sequences for FBLN1
miRNA for FBLN1 Gene
- miRTarBase miRNAs that target FBLN1
miRNA Products
- Search ViGene Biosciences for FBLN1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FBLN1
- Browse OriGene Inhibitory RNA Products For FBLN1
-
ViGene Biosciences ready-to-package AAV shRNAs for FBLN1 gene
Clone Products
- Sino Biological Human cDNA Clone for FBLN1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for FBLN1
-
ViGene Biosciences adenoviral particle packaged cDNA for FBLN1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FBLN1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FBLN1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FBLN1 Gene
Localization for FBLN1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FBLN1 Gene
- Secreted, extracellular space, extracellular matrix.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytoskeleton | 3 |
| cytosol | 3 |
| plasma membrane | 2 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS,IEA | -- |
| GO:0005577 | colocalizes_with fibrinogen complex | IDA | 7642629 |
| GO:0005578 | proteinaceous extracellular matrix | IEA,IDA | 2269669 |
| GO:0005604 | basement membrane | IEA | -- |
| GO:0005615 | extracellular space | IDA | 2269669 |
Pathways & Interactions for FBLN1 Gene
Pathways by source for FBLN1 Gene
3 Reactome pathways for FBLN1 Gene
1 GeneGo (Thomson Reuters) pathway for FBLN1 Gene
Interacting Proteins for FBLN1 Gene
Selected Interacting proteins:
ENSP00000331544
P23142-FBLN1_HUMAN
for FBLN1 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001933 | negative regulation of protein phosphorylation | IDA | 11792823 |
| GO:0007162 | negative regulation of cell adhesion | IDA | 11792823 |
| GO:0007229 | NOT integrin-mediated signaling pathway | IDA | 11792823 |
| GO:0007566 | embryo implantation | IEA | -- |
| GO:0010952 | positive regulation of peptidase activity | IEA | -- |
No data available for SIGNOR curated interactions for FBLN1 Gene
Transcripts for FBLN1 Gene
mRNA/cDNA for FBLN1 Gene
- (4) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (1331) Selected AceView cDNA sequences:
- (18) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FBLN1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBLN1
- GenScript: Design CRISPR guide RNA sequences for FBLN1
miRNA Products
- Search ViGene Biosciences for FBLN1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FBLN1
- Browse OriGene Inhibitory RNA Products For FBLN1
-
ViGene Biosciences ready-to-package AAV shRNAs for FBLN1 gene
Clone Products
- Sino Biological Human cDNA Clone for FBLN1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
| ExUns: | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22a | · | 22b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||
| SP2: | - | - | |||||||||||
| SP3: | |||||||||||||
| SP4: | |||||||||||||
| SP5: | |||||||||||||
| SP6: | |||||||||||||
| SP7: | |||||||||||||
| SP8: | |||||||||||||
| SP9: |
Expression for FBLN1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Endocardial Cushion Cells Atrioventricular Endocardial Cushion
mRNA differential expression in normal tissues according to GTEx for FBLN1 Gene
This gene is overexpressed in Vagina (x4.2).
This gene is overexpressed in Urinary Bladder (9.8), Uterus (7.6), Prostate (7.5), and Cerebrospinal fluid (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBLN1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of FBLN1 Gene:
FBLN1SOURCE GeneReport for Unigene cluster for FBLN1 Gene:
Hs.24601mRNA Expression by UniProt/SwissProt for FBLN1 Gene:
P23142-FBLN1_HUMAN
Tissue specificity:
Isoform A and isoform B are only expressed in placenta. Isoform C and isoform D are expressed in a variety of tissues and cultured cells.
Evidence on tissue expression from TISSUES for FBLN1 Gene
- Nervous system(4.9)
- Liver(4.2)
- Intestine(3.8)
- Lung(3.2)
- Eye(3)
- Heart(2.9)
- Muscle(2.8)
- Gall bladder(2.6)
- Skin(2.6)
- Stomach(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for FBLN1 Gene
Germ Layers:
- mesoderm
Systems:
- skeleton
Organs:
Limb:
- digit
- finger
- foot
- hand
- lower limb
- toe
- upper limb
Primer Products
-
OriGene qPCR primer pairs and template standards for FBLN1
-
OriGene qPCR primer pairs for FBLN1
Orthologs for FBLN1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBLN1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FBLN1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FBLN1 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fbln1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbln1 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FBLN1 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FBLN1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FBLN1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FBLN1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.5023 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.15054 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fbln1 34 35 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10824 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | fbl-1 34 |
|
||
| him-4 35 |
|
OneToMany |
- Species where no ortholog for FBLN1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FBLN1 Gene
Paralogs for FBLN1 Gene
(14) SIMAP similar genes for FBLN1 Gene using alignment to 12 proteins:
Variants for FBLN1 Gene
| SNP ID | Clin | Chr 22 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs397509432 | Pathogenic | 45,542,278(+) | GATGT(G/T)TGTCG | reference, missense | |
| rs142798380 | Likely benign | 45,547,213(+) | CGGAC(A/G)CCCCT | intron-variant | |
| rs559662894 | Likely benign | 45,503,057(+) | CTGGC(A/G)GCCGG | reference, synonymous-codon | |
| rs143377110 | Uncertain significance | 45,577,061(+) | CCTGC(A/G/T)GGACT | reference, missense | |
| rs147528917 | Uncertain significance | 45,542,162(+) | GTGGA(C/T)GAGTG | reference, synonymous-codon |
Residual Variation Intolerance Score:
21.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.76;
47.05% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FBLN1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBLN1 Gene
Disorders for FBLN1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| synpolydactyly, 3/3'4, associated with metacarpal and metatarsal synostoses |
|
|
| fbln1-related developmental delay-central nervous system anomaly-syndactyly syndrome |
|
|
| vitreoretinal dystrophy |
|
|
| familial osteochondritis dissecans |
|
|
| synpolydactyly |
|
|
Search FBLN1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
FBLN1_HUMAN- Note=A chromosomal aberration involving FBLN1 is found in a complex type of synpolydactyly referred to as 3/3-prime/4 synpolydactyly associated with metacarpal and metatarsal synostoses. Reciprocal translocation t(12;22)(p11.2;q13.3) with RASSF8. Fibroblasts derived from a patient with synpolydactyly displayed alterations in the level of isoform D splice variant incorporated into the ECM and secreted into the conditioned culture medium. By contrast, the expression of isoform C was not perturbed in the patients fibroblasts. Furthermore, no aberrant polypeptides were detected in extracts of cultured patients fibroblasts. The translocation t(12;22) may result in haploinsufficiency of the isoform D splice variant, which could lead to the observed limb malformation. {ECO:0000269 PubMed:11836357}.
- Note=Elevated expression and altered processing of FBLN1 protein is associated with human breast cancer. {ECO:0000269 PubMed:12644824}.
Relevant External Links for FBLN1
No data available for Genatlas for FBLN1 Gene
Publications for FBLN1 Gene
- Elevated expression and altered processing of fibulin-1 protein in human breast cancer. (PMID: 12644824) Greene L.M. … Gallagher W.M. (Br. J. Cancer 2003) 3 4 22 64
- Structural and functional characterization of the human and mouse fibulin-1 gene promoters: role of Sp1 and Sp3. (PMID: 11829738) Castoldi M. … Chu M.-L. (Biochem. J. 2002) 3 4 22 64
- The fibulin-1 gene (FBLN1) is disrupted in a t(12;22) associated with a complex type of synpolydactyly. (PMID: 11836357) Debeer P. … Van De Ven W.J.M. (J. Med. Genet. 2002) 3 4 22 64
- Estrogen induction and overexpression of fibulin-1C mRNA in ovarian cancer cells. (PMID: 11850827) Moll F. … Pujol P. (Oncogene 2002) 3 4 22 64
- Interaction of oncogenic papillomavirus E6 proteins with fibulin-1. (PMID: 12200142) Du M. … Chen J.J. (Biochem. Biophys. Res. Commun. 2002) 3 4 22 64
Products for FBLN1 Gene
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- Cloud-Clone Corp. Antibodies for FBLN1
- Cloud-Clone Corp. Proteins for FBLN1
- antibodies-online Antibodies for FBLN1: See all 89
- antibodies-online Kits for FBLN1: See all 15
- antibodies-online Proteins for FBLN1: See all 16
- Search antibodies-online for peptides
- GeneTex FBLN1 antibody for FBLN1
- Search GeneTex for Proteins for FBLN1
- ViGene Biosciences adenoviral particle packaged cDNA for FBLN1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FBLN1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FBLN1 gene
- Search ViGene Biosciences for FBLN1
- Santa Cruz Biotechnology (SCBT) Antibodies for FBLN1
- Search Santa Cruz Biotechnology (SCBT) for FBLN1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FBLN1
- Horizon Cell Lines for FBLN1
- Cyagen custom Knockout/knockin (KOKI) mouse models for FBLN1
- VectorBuilder custom plasmid, inducible vectors for FBLN1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FBLN1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FBLN1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer