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Aliases for FBLL1 Gene

Aliases for FBLL1 Gene

  • Fibrillarin-Like 1 2 3 5
  • Protein-Glutamine Methyltransferase 4
  • EC 2.1.1.- 4
  • EC 2.1.1 63

External Ids for FBLL1 Gene

Previous GeneCards Identifiers for FBLL1 Gene

  • GC05P167889
  • GC05P163055
  • GC05P167956

Summaries for FBLL1 Gene

GeneCards Summary for FBLL1 Gene

FBLL1 (Fibrillarin-Like 1) is a Pseudogene. GO annotations related to this gene include RNA binding and methyltransferase activity. An important paralog of this gene is FBL.

UniProtKB/Swiss-Prot for FBLL1 Gene

  • S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Also acts as a protein methyltransferase by mediating methylation of glutamine residues (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBLL1 Gene

Genomics for FBLL1 Gene

Regulatory Elements for FBLL1 Gene

Genomic Location for FBLL1 Gene

Chromosome:
5
Start:
168,529,116 bp from pter
End:
168,530,634 bp from pter
Size:
1,519 bases
Orientation:
Plus strand

Genomic View for FBLL1 Gene

Genes around FBLL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBLL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBLL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBLL1 Gene

Proteins for FBLL1 Gene

  • Protein details for FBLL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NHQ2-FBLL1_HUMAN
    Recommended name:
    rRNA/tRNA 2-O-methyltransferase fibrillarin-like protein 1
    Protein Accession:
    A6NHQ2
    Secondary Accessions:
    • R4GMW7

    Protein attributes for FBLL1 Gene

    Size:
    334 amino acids
    Molecular mass:
    34803 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FBLL1 Gene

Proteomics data for FBLL1 Gene at MOPED

Post-translational modifications for FBLL1 Gene

  • By homology to other fibrillarins, some or all of the N-terminal domain arginines are modified to asymmetric dimethylarginine (DMA).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBLL1 Gene

ENSEMBL proteins:

Domains & Families for FBLL1 Gene

Protein Domains for FBLL1 Gene

Suggested Antigen Peptide Sequences for FBLL1 Gene

Graphical View of Domain Structure for InterPro Entry

A6NHQ2

UniProtKB/Swiss-Prot:

FBLL1_HUMAN :
  • Belongs to the methyltransferase superfamily. Fibrillarin family.
Family:
  • Belongs to the methyltransferase superfamily. Fibrillarin family.
genes like me logo Genes that share domains with FBLL1: view

No data available for Gene Families for FBLL1 Gene

Function for FBLL1 Gene

Molecular function for FBLL1 Gene

UniProtKB/Swiss-Prot Function:
S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Also acts as a protein methyltransferase by mediating methylation of glutamine residues (By similarity).

Enzyme Numbers (IUBMB) for FBLL1 Gene

Gene Ontology (GO) - Molecular Function for FBLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1990259 histone-glutamine methyltransferase activity IBA --
genes like me logo Genes that share ontologies with FBLL1: view

Phenotypes for FBLL1 Gene

GenomeRNAi human phenotypes for FBLL1:
genes like me logo Genes that share phenotypes with FBLL1: view

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FBLL1 Gene

Localization for FBLL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBLL1 Gene

Nucleus, nucleolus. Note=Fibrillar region of the nucleolus. {ECO:0000250}.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for FBLL1 Gene

Pathways & Interactions for FBLL1 Gene

SuperPathways for FBLL1 Gene

No Data Available

Interacting Proteins for FBLL1 Gene

Selected Interacting proteins: A6NHQ2-FBLL1_HUMAN for FBLL1 Gene via I2D

Symbol External ID(s) Details
ESR2

Gene Ontology (GO) - Biological Process for FBLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IEA --
genes like me logo Genes that share ontologies with FBLL1: view

No data available for Pathways by source and SIGNOR curated interactions for FBLL1 Gene

Drugs & Compounds for FBLL1 Gene

(1) Drugs for FBLL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
genes like me logo Genes that share compounds with FBLL1: view

Transcripts for FBLL1 Gene

mRNA/cDNA for FBLL1 Gene

(1) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FBLL1 Gene

Fibrillarin-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBLL1 Gene

No ASD Table

Relevant External Links for FBLL1 Gene

GeneLoc Exon Structure for
FBLL1
ECgene alternative splicing isoforms for
FBLL1

Expression for FBLL1 Gene

mRNA expression in normal human tissues for FBLL1 Gene

mRNA differential expression in normal tissues according to GTEx for FBLL1 Gene

This gene is overexpressed in Brain - Hypothalamus (x5.4), Brain - Frontal Cortex (BA9) (x5.0), Brain - Cortex (x4.9), and Brain - Anterior cingulate cortex (BA24) (x4.7).

Protein differential expression in normal tissues from HIPED for FBLL1 Gene

This gene is overexpressed in CD8 Tcells (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for FBLL1 Gene



SOURCE GeneReport for Unigene cluster for FBLL1 Gene Hs.166262

genes like me logo Genes that share expression patterns with FBLL1: view

Protein tissue co-expression partners for FBLL1 Gene

- Elite partner

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FBLL1 Gene

Orthologs for FBLL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FBLL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FBLL1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbll1 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 72 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 72 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii fbl 36
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10909 36
  • 32 (a)
ManyToMany
Fib 36
  • 67 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea fib-1 36
  • 58 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOP1 36
  • 58 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.47666 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5018 36
  • 67 (a)
OneToMany
Species with no ortholog for FBLL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FBLL1 Gene

ENSEMBL:
Gene Tree for FBLL1 (if available)
TreeFam:
Gene Tree for FBLL1 (if available)

Paralogs for FBLL1 Gene

Paralogs for FBLL1 Gene

(1) SIMAP similar genes for FBLL1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FBLL1: view

Variants for FBLL1 Gene

Sequence variations from dbSNP and Humsavar for FBLL1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1870053 -- 168,529,357(+) GAGCC(C/G)GTCCT upstream-variant-2KB
rs7446077 -- 168,529,369(+) ccccc(C/G)ccgcc upstream-variant-2KB
rs28535793 -- 168,528,363(+) ATCAT(A/T)CATTT upstream-variant-2KB
rs74622872 -- 168,528,138(+) AATAT(A/G)CCAAT upstream-variant-2KB
rs56664166 -- 168,530,947(+) ACTGA(A/G)TGTTG downstream-variant-500B

Variation tolerance for FBLL1 Gene

Gene Damage Index Score: 10.16; 90.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBLL1 Gene

HapMap Linkage Disequilibrium report
FBLL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FBLL1 Gene

Disorders for FBLL1 Gene

Relevant External Links for FBLL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBLL1

No disorders were found for FBLL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBLL1 Gene

Publications for FBLL1 Gene

  1. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. (PMID: 24639526) Carmon K.S. … Liu Q. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 67
  2. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3
  3. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for FBLL1 Gene

Sources for FBLL1 Gene

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