FBLIM1 Gene
protein-coding GIFtS: 54
GCID: GC01P016083
|
|
filamin binding LIM protein 1
| |
Aliases for FBLIM1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Filamin Binding LIM Protein 11 2 | | CSX-Associated LIM2 | | FBLP-11 2 3 | | Filamin-Binding LIM Protein 12 | | FBLP12 3 5 | | Filamin-Binding LIM Protein-12 | | CAL1 2 | | Mitogen-Inducible 2 Interacting Protein2 | | Migfilin3 | | Migfilin3 | | Mitogen-Inducible 2-Interacting Protein2 3 | | MIGFILIN5 | | MIG2-Interacting Protein2 3 | | |
Export aliases for FBLIM1 gene to outside databasesPrevious GC identifers: GC01P015829 GC01P015955 GC01P014604 |
Summaries for FBLIM1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for FBLIM1: This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multipleC-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actincytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays arole in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus andmay affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicingresults in multiple transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: FBLI1_HUMAN, Q8WUP2Function: Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Isimplicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediatedcross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signalingcomplexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation ofintegrins and regulates integrin-mediated cell-cell adhesion Gene Wiki entry for FBLIM1
|
Genomic Views for FBLIM1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FBLIM1 gene promoter: Nkx2-5 Other transcription factors
Search SABiosciences Chromatin IP Primers for FBLIM1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBLIM1 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.21 Ensembl cytogenetic band: 1p36.21 HGNC cytogenetic band: 1p36.13FBLIM1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P016083: view genomic region
(about GC identifiers)
Start:
|
16,083,102 bp from pter |
End:
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16,113,089 bp from pter |
Size:
|
29,988 bases |
Orientation:
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plus strand |
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Proteins for FBLIM1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: FBLI1_HUMAN, Q8WUP2 (See
protein sequence)Recommended Name: Filamin-binding LIM protein 1 Size: 373 amino acids; 40670 Da
Subunit: Interacts with NKX2-5 (By similarity). Isoform 1 and isoform 3 interact with PLEKHC1, FLNA, FLNB and FLNC.Isoform 2 interacts with FLNB
Subcellular location: Cytoplasm, cell cortex. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Associatedwith actin stress fiber at cell-ECM focal adhesion sites. Isoform 1 and isoform 3 are recruited and localized at actinstress fibers and clustered at cell-EMC adhesion sites through interaction with PLEKHC1. Isoform 2 is localized atactin stress fibers
2 PDB 3D structures from and Proteopedia for FBLIM1:2K9U (3D)
  2W0P (3D)
 
Secondary accessions: B3KNY0 Q5VVE0 Q5VVE1 Q8IX23 Q96T00 Q9UFD6Alternative splicing: 3 isoforms: Q8WUP2-1 Q8WUP2-2 Q8WUP2-3 (May be due to exon skipping)Explore the universe of human proteins at neXtProt for FBLIM1: NX_Q8WUP2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WUP2 FBLIM1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001019386.1 NP_001019387.1 NP_060026.2 ENSEMBL proteins: ENSP00000422862 ENSP00000423471 ENSP00000421885 ENSP00000387595 ENSP00000364926 ENSP00000421764 ENSP00000422075 ENSP00000364921 ENSP00000427052 ENSP00000424920 ENSP00000402401 ENSP00000416387 ENSP00000364920 ENSP00000383584 Reactome Protein details: Q8WUP2 Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
FBLIM1 for ontologies About GeneDecksing
FBLIM1 Antibody Products: Assay Products for FBLIM1: |
Protein
Domains / Families for FBLIM1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FBLIM1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8WUP2ProtoNet protein and cluster: Q8WUP2 1 Blocks protein family: IPB001781 Zn-binding protein
UniProtKB/Swiss-Prot: FBLI1_HUMAN, Q8WUP2Domain: The N-terminal region is intrinsically disorderedSimilarity: Contains 3 LIM zinc-binding domains |
Function for FBLIM1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: FBLI1_HUMAN, Q8WUP2Function: Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Isimplicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediatedcross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signalingcomplexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation ofintegrins and regulates integrin-mediated cell-cell adhesion
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBLIM1 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBLIM1 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): FBLIM1 (NM_001024215) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBLIM1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBLIM1  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBLIM1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
FBLIM1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for FBLIM1: Animal Models: Mouse knock-outs for FBLIM1: Fblim1tm1.1Chen Fblim1tm1.2Ref 6 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Fblim1):
FBLIM1 for phenotypes About GeneDecksing
|
Pathways & Interactions for FBLIM1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell-cell junction organization | | | 2 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | |
Pathway sources See GeneCards unified pathways Show all pathways
3
Reactome Pathways for FBLIM1
FBLIM1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBLIM1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
 5/8 Interacting proteins for FBLIM1 (Q8WUP23 ENSP000004163874) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
FBLIM1 for ontologies About GeneDecksing
|
Drugs & Compounds for FBLIM1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for FBLIM1 Search CenterWatch for drugs/clinical trials and news about FBLIM1 / FBLI1 
|
Transcripts for FBLIM1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for FBLIM1 gene (3 alternative transcripts): NM_001024215.1 NM_001024216.1 NM_017556.2 Unigene Cluster for FBLIM1: Filamin binding LIM protein 1 Hs.530101 [show with all ESTs]Unigene Representative Sequence: NM_01755616 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000496928 ENST00000508310 ENST00000510393 ENST00000430076 ENST00000375771(uc001axd.1) ENST00000510929 ENST00000502638 ENST00000375766(uc001axe.1) ENST00000483633 ENST00000502739 ENST00000431771 ENST00000441801(uc001axg.1) ENST00000332305 ENST00000514156 ENST00000509138 ENST00000400773(uc001axh.1 uc001axi.1)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBLIM1 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBLIM1 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): FBLIM1 (NM_001024215) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBLIM1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBLIM1  |
Additional cDNA sequence: AF459643.1 AK027444.1 AK055259.1 AK130732.1 AL133035.1 AY180161.1 BC019895.1 14 DOTS entries: DT.97838125 DT.436153 DT.100839005 DT.101981007 DT.121450044 DT.97848825 DT.121450051 DT.100787720 DT.95372266 DT.102831127 DT.102831129 DT.121450060 DT.121450041 DT.91741673 24/165 AceView cDNA sequences (see all 165): BG747555 BQ082420 BX096040 CB141474 BI334171 BU191604 BM721201 AW243569 CR604326 BM822883 AI867436 BQ674645 BU633652 AK055259 BF438298 AW614039 AW083637 AI638392 AI972796 AW179068 BM713018 BM837809 BM726731 CB215706 GeneLoc Exon Structure
5/17 Alternative Splicing Database (ASD) splice patterns (SP) for FBLIM1 (see all 17) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | · | 7f | · | 7g | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |
| SP2: | |   | |   | - |   | - |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | - |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | - |   | - |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | - |   | - |   | |   | |   | - |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 12b | ^ | 13a | · | 13b | |
| SP1: | |   | |   | |   | |
| SP2: | |   | |   | |   | |
| SP3: | |   | |   | |   | |
| SP4: | |   | |   | |   | |
| SP5: | |   | |   | |   |
ECgene alternative splicing isoforms for FBLIM1
|
Expression for FBLIM1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FBLIM1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
About this image See FBLIM1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FBLIM1
SOURCE GeneReport for Unigene cluster: Hs.530101 UniProtKB/Swiss-Prot: FBLI1_HUMAN, Q8WUP2Tissue specificity: Isoform 1 and isoform 3 are expressed in heart, kidney, lung, pancreas, placenta and platelets.Isoform 2 is expressed in brain, heart, kidney, lung, pancreas, placenta, skeletal muscle and platelets SABiosciences Custom PCR Arrays for FBLIM1
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBLIM1 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBLIM1 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBLIM1 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBLIM1 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBLIM1 |
Orthologs for FBLIM1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FBLIM1 gene from 3/13 species (see all 13) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
FBLIM11 |
filamin binding LIM protein 1 |
62.36(n) 52.92(a) |
  |
419458 XM_417617.3 XP_417617.2 |
zebrafish (Danio rerio) |
Actinopterygii |
zgc:1541761 |
zgc:154176 |
55.8(n) 48.66(a) |
  |
768160 NM_001077303.1 NP_001070771.1 |
worm (Caenorhabditis elegans) |
Secernentea |
zyx-16 |
ZYXin family member (zyx-1) |
10(a) |
1 → many |
II(13056744-13071460) |
ENSEMBL Gene Tree for FBLIM1 (if available) TreeFam Gene Tree for FBLIM1 (if available)  |
Paralogs for FBLIM1 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for FBLIM1 gene
- LPP2 TRIP62 AJUBA2 WTIP2 ZYX2 LIMD12
9 SIMAP similar genes for FBLIM1 using alignment to 10 protein entries: FBLI1_HUMAN (see all proteins):LHX8 LHX4 LHx4 CRIP1 ZYX FHL1 LMO2 TRIP6 TRIP6i1
FBLIM1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for FBLIM1 PGOHUM00000242661 PGOHUM00000241531
|
Genomic Variants for FBLIM1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 1 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for FBLIM1 (16083102 - 16113089 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for FBLIM1 1 CNV: 53278 Human Gene Mutation Database (HGMD): FBLIM1
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBLIM1 |
|
Disorders
/ Diseases for FBLIM1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FBLIM1 for disorders About GeneDecksing
OMIM gene information: 607747
OMIM disorders: --
7 diseases for FBLIM1: About MalaCardsepidermolysis bullosa kindler syndrome skin atrophy lipoma leiomyosarcoma chondrosarcoma breast cancer 1 disease from the University of Copenhagen DISEASES database for FBLIM1:Skin atrophy Export disorders for FBLIM1 gene to outside databases
|
Publications for FBLIM1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FBLIM1 gene, integrated from 9 sources (see all 31): (articles sorted by number of sources associating them with FBLIM1) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation. (PubMed id 12679033)1, 2, 3, 9 Tu Y.... Wu C. (2003)
- A new member of the LIM protein family binds to filamin B and localizes at stress fibers. (PubMed id 12496242)1, 2, 3, 9 Takafuta T....Shapiro S.S. (2003)
- Structural Basis of the Migfilin-Filamin Interaction and Competition with Integrin {beta} Tails. (PubMed id 18829455)1, 2, 9 Lad Y....Calderwood D.A. (2008)
- Migfilin, a molecular switch in regulation of integrin activation. (PubMed id 19074766)1, 2, 9 Ithychanda S.S....Qin J. (2009)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Physical and functional association of migfilin with cell-cell adhesions. (PubMed id 15671069)1, 9 Gkretsi V....Wu C. (2005)
- Migfilin interacts with vasodilator-stimulated phosphoprotein (VASP) and regulates VASP localization to cell-matrix adhesions and migration. (PubMed id 16531412)1, 9 Zhang Y....Wu C. (2006)
- Migfilin interacts with Src and contributes to cell-m atrix adhesion-mediated survival signaling. (PubMed id 19833732)1, 9 Zhao J....Wu C. (2009)
|
External Searches for FBLIM1 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing FBLIM1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FBLIM1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FBLIM1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for FBLIM1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FBLIM1 gene: Search GeneIP for patents involving FBLIM1
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for FBLIM1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for FBLIM1 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FBLIM1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBLIM1 | | OriGene Protein Over-expression Lysate for FBLIM1 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for FBLIM1 | | OriGene 3'-UTR Clone for FBLIM1 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBLIM1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBLIM1 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | OriGene Purified Protein for FBLIM1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for FBLIM1 | | OriGene Custom Protein Services for FBLIM1 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FBLIM1 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBLIM1 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBLIM1 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBLIM1 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBLIM1 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBLIM1 |
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| | | Search Tocris compounds for FBLIM1 |
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 | | FBLIM1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBLIM1 |
|  |  |  | | | Search ThermoFisher Antibodies for FBLIM1 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBLIM1 |
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