Aliases for FBLIM1 Gene
External Ids for FBLIM1 Gene
Previous GeneCards Identifiers for FBLIM1 Gene
This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for FBLIM1 Gene
FBLIM1 (Filamin Binding LIM Protein 1) is a Protein Coding gene. Diseases associated with FBLIM1 include skin atrophy and ovarian serous carcinoma. Among its related pathways are ERK Signaling and Cell junction organization. GO annotations related to this gene include filamin binding. An important paralog of this gene is AJUBA.
UniProtKB/Swiss-Prot for FBLIM1 Gene
Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion.