FBL Gene
protein-coding GIFtS: 65
GCID: GC19M040325
|
|
fibrillarin
| |
Aliases
for FBL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fibrillarin1 | | RNA, U3 Small Nucleolar Interacting Protein 12 | | FLRN1 2 3 | | RRNA 2'-O-Methyltransferase Fibrillarin2 | | FIB1 2 | | EC 2.1.1.-3 | | RNU3IP11 2 | | FIB13 | | 34 KDa Nucleolar Scleroderma Antigen2 3 | | EC 2.1.18 | | 34-KD Nucleolar Scleroderma Antigen2 | | EC 2.1.1.378 |
Export aliases for FBL gene to outside databasesPrevious GC identifers: GC19M040966 GC19M040716 GC19M045001 GC19M045016 GC19M036772 |
Summaries
for FBL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FBL:
This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participatein the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and islocated in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitivedomain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resemblesan RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with theautoimmune disease scleroderma recognize fibrillarin. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: FBRL_HUMAN, P22087Function: Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze thesite-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guideRNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved inbase pairing with the guide RNA
Gene Wiki entry for FBL (Fibrillarin)
|
Genomic Views
for FBL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FBL gene promoter:
CREB deltaCREB MyoD C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for FBL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.1 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.1FBL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M040325: view genomic region
(about GC identifiers)
Start:
|
40,325,093 bp from pter |
End:
|
40,337,054 bp from pter |
Size:
|
11,962 bases |
Orientation:
|
minus strand |
|
Proteins
for FBL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FBRL_HUMAN, P22087 (See
protein sequence)Recommended Name: rRNA 2'-O-methyltransferase fibrillarin Size: 321 amino acids; 33784 Da
Subunit: Interacts with NOLC1 (By similarity). Component of box C/D small nucleolar ribonucleoprotein (snoRNP)particles that contain NHP2L1, FBL, NOP5 and NOP56, plus a guide RNA. It is associated with the U3, U8, U13, X and Ysmall nuclear RNAs. Component of several ribosomal and nucleolar protein complexes. Interacts with PRMT5 and UTP20.Interacts with DDX5 and C1QBP
Subcellular location: Nucleus, nucleolus. Note=Fibrillar region of the nucleolus
1 PDB 3D structure from  and Proteopedia  for FBL:2IPX (3D)
Secondary accessions: B5BUE8 O75259 Q6IAT5 Q9UPI6Explore the universe of human proteins at neXtProt for FBL: NX_P22087
Post-translational modifications:
By homology to other fibrillarins, some or all of the N-terminal domain arginines are modified to asymmetricdimethylarginine (DMA)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P22087
4/17 DME Specific Peptides for FBL (P22087) (see all 17)
FBL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001427.2
ENSEMBL proteins: ENSP00000221801
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
FBL for ontologies About GeneDecksing
FBL Antibody Products:
Assay Products for FBL: |
Protein
Domains /
Families
for FBL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FBL for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P22087ProtoNet protein and cluster: P22087 1 Blocks protein family: IPB000692 Fibrillarin
UniProtKB/Swiss-Prot: FBRL_HUMAN, P22087Similarity: Belongs to the methyltransferase superfamily. Fibrillarin family |
Function
for FBL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FBRL_HUMAN, P22087Function: Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze thesite-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guideRNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved inbase pairing with the guide RNAEnzyme Numbers (IUBMB): EC 2.1.1.-1 EC 2.1.12 EC 2.1.1.372
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBL (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FBL (NM_001436) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBL |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBL |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
FBL for ontologies About GeneDecksing
10 GenomeRNAi human phenotypes for FBL:
Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Fbl):
FBL for phenotypes About GeneDecksing
|
Pathways & Interactions
for FBL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cytoskeletal Signaling | | | 2 | TNF-alpha/NF-kB Signaling Pathway | | | 3 | Ribosome biogenesis in eukaryotes | | | 4 | Chromatin Regulation / Acetylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Cell Signaling Technology (CST) Pathways for FBL
1  BioSystems Pathway for FBL
1 
Kegg Pathway (Kegg details for FBL):
FBL for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FBL
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/306 Interacting proteins for FBL (P220871, 2, 3 ENSP000002218014) via UniProtKB, MINT, STRING, and/or I2D (see all 306)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
FBL for ontologies About GeneDecksing
|
Drugs & Compounds
for FBL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
FBL for compounds About GeneDecksing
 Browse Tocris compounds for FBL
1 HMDB Compound for FBL About this table
9 Novoseek chemical compound relationships for FBL gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| rrna |
62 |
7 |
8508778 (1), 11509571 (1), 19562966 (1), 10942594 (1) (see all 7) |
| actinomycin d |
61.5 |
9 |
15210063 (4), 9211978 (2), 10512052 (1), 17205309 (1) (see all 5) |
| arginine |
38.4 |
14 |
12523648 (3), 14583623 (1), 1846968 (1), 10518318 (1) (see all 9) |
| hgcl2 |
33.8 |
4 |
10685806 (1), 7529293 (1) |
| toluidine |
19.5 |
1 |
9588897 (1) |
| mercury |
19.3 |
12 |
10942594 (3), 10685806 (2), 8187336 (1), 11580225 (1) (see all 5) |
| nacl |
0 |
1 |
10512052 (1) |
| silver |
0 |
1 |
9188763 (1) |
| serine |
0 |
2 |
16373587 (1), 18836177 (1) |
Search CenterWatch for drugs/clinical trials and news about FBL / FBRL
|
Transcripts
for FBL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FBL gene: NM_001436.3 Unigene Cluster for FBL: Fibrillarin Hs.299002 [show with all ESTs]Unigene Representative Sequence: BG3244461 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000221801(uc002omn.3 uc002omm.1 uc002omo.2 uc010egr.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBL (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FBL (NM_001436) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBL | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBL |
Additional cDNA sequence: AB451384.1 AK296950.1 AK308649.1 BC015218.2 BC019260.1 BC019609.1 BT006830.1 BT020144.1 CR457069.1 M59849.1 X56597.1 24/32 DOTS entries (see all 32): DT.97862649 DT.99926462 DT.100686044 DT.95314955 DT.92464308 DT.121421980 DT.100686046 DT.92403610 DT.95365934 DT.100686048 DT.100866653 DT.121421996 DT.100686042 DT.95366033 DT.100686028 DT.100686030 DT.102840689 DT.121422000 DT.121422060 DT.121422064 DT.75129766 DT.91892615 DT.92030034 DT.95365912 24/912 AceView cDNA sequences (see all 912): BQ213787 BM667716 BU735529 BM809155 BC019260 AA299195 BQ691398 CR592096 BE740062 BE792566 N24905 BU164191 BE904982 BU179974 BQ689834 CB136677 BQ689951 BU517286 AW250801 AI469476 BQ936516 BM423376 AA333882 AA309748
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for FBL (see all 12) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | - | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FBL
|
Expression
for FBL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FBL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCGTGGTCGT
About this image
See FBL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FBL
SOURCE GeneReport for Unigene cluster: Hs.299002
SABiosciences Custom PCR Arrays for FBL
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FBL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBL |
Orthologs
for FBL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for FBL gene from 9/40 species (see all 40) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Fbl1 , 5 |
fibrillarin1, 5 |
87.5(n)1
97.81(a)1 |
|
7 (16.67 cM)5
141131 NM_007991.31 NP_032017.21
281697485 |
lizard
(Anolis carolinensis) |
Reptilia |
FBL6 |
-- |
81(a) |
1 ↔ 1 |
GL343276.1(1675845-1686295) |
African clawed frog
(Xenopus laevis) |
Amphibia |
LOC3984342 |
hypothetical protein LOC398434 |
75.2(n) |
|
BC045093.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb37g122 |
Danio rerio cDNA clone MGC56145 IMAGE5412217, complete more |
74.45(n) |
|
BC051777.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG109093
Fib1 |
35S primary transcript processing3
Fibrillarin1 |
44(a)3
71.03(n)1
81.47(a)1 |
|
87D43
376621 NM_079093.21 NP_523817.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
fib-11 , 3 |
fibrillarin3
Protein FIB-11 |
76(a)3
67.31(n)1
73.31(a)1 |
|
V(15003363-15004563)3
1799991 NM_074290.31 NP_506691.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
NOP1(YDL014W)4
NOP11 |
Nucleolar protein, component of the small subunit processome more4
Nop1p1 |
63.63(n)1
70.36(a)1 |
|
4(427364-428347)4
8515481, 4 NP_010270.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
FIB11 |
rRNA 2'-O-methyltransferase fibrillarin 1 |
67.01(n)
76.61(a) |
|
835323 NM_124626.4 NP_568772.3 |
rice
(Oryza sativa) |
Liliopsida |
Os02g08218001 |
hypothetical protein |
67.93(n)
72.15(a) |
|
4331181 NM_001055088.1 NP_001048553.1 |
ENSEMBL Gene Tree for FBL (if available)
TreeFam Gene Tree for FBL (if available) |
Paralogs
for FBL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FBL gene
1 SIMAP similar gene for FBL using alignment to 10 protein entries: FBRL_HUMAN (see all proteins):FBLL1
FBL for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for FBL
PGOHUM00000245782 PGOHUM00000257133
|
Genomic Variants
for FBL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FBL (40325093 - 40337054 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FBL
2 CNVs: 30906 4079 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBL |
|
Disorders
/ Diseases
for FBL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FBL for disorders About GeneDecksing
OMIM gene information: 134795
OMIM disorders: --
17  diseases for FBL: About MalaCardsscleroderma spinal muscular atrophy connective tissue disease treacher collins syndrome
muscular atrophy diffuse scleroderma lupus erythematosus polymyositis
systemic scleroderma dermatomyositis myositis hepatitis c
hepatitis b influenza hepatitis malaria
neuronitis
2 diseases from the University of Copenhagen DISEASES database for FBL:Liver disease Hepatitis C 10/15 Novoseek disease relationships for FBL gene (see all 15) About this table
Human Genome Epidemiology (HuGE) Navigator: FBL (3 documents)
Export disorders for FBL gene to outside databases
|
Publications
for FBL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FBL gene, integrated from 9 sources (see all 224):
(articles sorted by number of sources associating them with FBL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera. (PubMed id 1846968)1, 2, 3, 9 Aris J.P. and Blobel G. (1991)
- Evolutionary conservation of the human nucleolar protein fibrillarin and its functional expression in yeast. (PubMed id 2026646)1, 2, 3, 9 Jansen R.P....Tollervey D. (1991)
- Human fibrillarin forms a sub-complex with splicing factor 2- associated p32, protein arginine methyltransferases, and tubulins alpha 3 and beta 1 that is independent of its association with preribosomal ribonucleoprotein complexes. (PubMed id 14583623)1, 2, 9 Yanagida M.... Takahashi N. (2004)
- An intact Box C sequence in the U3 snRNA is required for binding of fibrillarin, the protein common to the major family of nucleolar snRNPs. (PubMed id 1714385)1, 2, 9 Baserga S.J.... Steitz J.A. (1991)
- Splicing factor 2-associated protein p32 participates in ribosome biogenesis by regulating the binding of Nop52 and fibrillarin to pre ribosome particles. (PubMed id 21536856)1, 2 Yoshikawa H....Takahashi N. (2011)
- Human 1A6/DRIM, the homolog of yeast Utp20, functions in the 18S rRNA processing. (PubMed id 17498821)1, 2 Wang Y....Ke Y. (2007)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The nuclear DEAD box RNA helicase p68 interacts with the nucleolar protein fibrillarin and colocalizes specifically in nascent nucleoli during telophase. (PubMed id 10837141)1, 2 Nicol S.M....Fuller-Pace F.V. (2000)
- Purification and partial characterization of a nucleolar scleroderma antigen (Mr = 34,000; pI, 8.5) rich in NG,NG-dimethylarginine. (PubMed id 2414294)1, 2 Lischwe M.A.... Busch H. (1985)
|
External Searches for FBL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing FBL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing FBL gene
(According to HUGE)
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Specialized Databases showing FBL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for FBL gene:
Search GeneIP for patents involving FBL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for FBL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FBL | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FBL | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBL | | | OriGene Protein Over-expression Lysate for FBL | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FBL | | OriGene 3'-UTR Clone for FBL | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBL | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FBL | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FBL | | OriGene Custom Protein Services for FBL | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FBL | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBL | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBL | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBL |
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| | Antibodies & Assays for FBL |
| | | | Search Tocris compounds for FBL |
| |  |  |  |  | | | | | | Recombinant Protein for FBL |
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 | | | FBL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBL |
|  |  |  | | | | ThermoFisher Antibodies for FBL |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBL |
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