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Aliases for FBF1 Gene

Aliases for FBF1 Gene

  • Fas (TNFRSF6) Binding Factor 1 2 3
  • Protein Albatross 3 4
  • Albatross 2 3
  • FBF-1 3 4
  • Alb 3 4
  • Fas Binding Protein 1 3
  • Fas-Binding Factor 1 3
  • KIAA1863 4

External Ids for FBF1 Gene

Previous GeneCards Identifiers for FBF1 Gene

  • GC17M074503
  • GC17M071417
  • GC17M073905
  • GC17M069332

Summaries for FBF1 Gene

GeneCards Summary for FBF1 Gene

FBF1 (Fas (TNFRSF6) Binding Factor 1) is a Protein Coding gene. Diseases associated with FBF1 include nocardiosis and hypermobility syndrome. Among its related pathways are Hemostasis and Hemostasis.

UniProtKB/Swiss-Prot for FBF1 Gene

  • Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBF1 Gene

Genomics for FBF1 Gene

Regulatory Elements for FBF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FBF1 Gene

Start:
75,909,574 bp from pter
End:
75,941,140 bp from pter
Size:
31,567 bases
Orientation:
Minus strand

Genomic View for FBF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBF1 Gene

Proteins for FBF1 Gene

  • Protein details for FBF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TES7-FBF1_HUMAN
    Recommended name:
    Fas-binding factor 1
    Protein Accession:
    Q8TES7
    Secondary Accessions:
    • B5MEM5
    • Q96IF6
    • Q96JG4
    • Q96MA8

    Protein attributes for FBF1 Gene

    Size:
    1133 amino acids
    Molecular mass:
    125446 Da
    Quaternary structure:
    • May interact with FAS cytoplasmic domain (By similarity). Interacts with PARD3.
    SequenceCaution:
    • Sequence=BAB71400.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB84871.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBF1 Gene

neXtProt entry for FBF1 Gene

Proteomics data for FBF1 Gene at MOPED

Post-translational modifications for FBF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBF1 Gene

Domains for FBF1 Gene

Protein Domains for FBF1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for FBF1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBF1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FBF1 Gene

Function for FBF1 Gene

Molecular function for FBF1 Gene

UniProtKB/Swiss-Prot Function: Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis.

Gene Ontology (GO) - Molecular Function for FBF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0003824 catalytic activity --
GO:0005515 protein binding IPI 18838552
genes like me logo Genes that share ontologies with FBF1: view
genes like me logo Genes that share phenotypes with FBF1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBF1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FBF1 Gene

Localization for FBF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBF1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Cell junction. Note=Localizes specifically to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane. Localizes to the apical junction complex (AJC) in epithelial cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBF1 Gene COMPARTMENTS Subcellular localization image for FBF1 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FBF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 21399614
GO:0005813 centrosome IDA --
GO:0005814 centriole IDA 23348840
GO:0005829 cytosol TAS --
GO:0043296 colocalizes_with apical junction complex IDA 18838552
genes like me logo Genes that share ontologies with FBF1: view

Pathways for FBF1 Gene

genes like me logo Genes that share pathways with FBF1: view

Pathways by source for FBF1 Gene

Gene Ontology (GO) - Biological Process for FBF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0042384 cilium assembly IMP 23348840
GO:0043297 apical junction assembly IMP 18838552
GO:0044237 cellular metabolic process --
GO:0090162 establishment of epithelial cell polarity IMP 18838552
genes like me logo Genes that share ontologies with FBF1: view

Transcripts for FBF1 Gene

Unigene Clusters for FBF1 Gene

Fas (TNFRSF6) binding factor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBF1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBF1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^
SP1:
SP2: - -
SP3: - - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:

ExUns: 20 ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b · 31c ^ 32 ^ 33 ^ 34a · 34b · 34c · 34d ^ 35a ·
SP1: - - - - - - - - - - - -
SP2: - -
SP3:
SP4: -
SP5: -
SP6: - - - -
SP7: - -
SP8:
SP9: - -
SP10:
SP11:
SP12:
SP13:
SP14: - - - - - - -
SP15:
SP16:
SP17: -
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:

ExUns: 35b ^ 36a · 36b ^ 37a · 37b ^ 38a · 38b · 38c · 38d · 38e ^ 39a · 39b ^ 40 ^ 41a · 41b · 41c ^ 42 ^ 43 ^ 44
SP1: - - - - - - - - -
SP2:
SP3:
SP4:
SP5:
SP6: - - - - - - -
SP7:
SP8: - - - - - - - - -
SP9:
SP10: - - - - - - - - -
SP11: - - -
SP12: -
SP13: - - -
SP14:
SP15:
SP16: -
SP17: - - - -
SP18: -
SP19:
SP20:
SP21:
SP22:
SP23:

Relevant External Links for FBF1 Gene

GeneLoc Exon Structure for
FBF1
ECgene alternative splicing isoforms for
FBF1

Expression for FBF1 Gene

mRNA expression in normal human tissues for FBF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBF1 Gene

This gene is overexpressed in Testis (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBF1 Gene

SOURCE GeneReport for Unigene cluster for FBF1 Gene Hs.720068

mRNA Expression by UniProt/SwissProt for FBF1 Gene

Q8TES7-FBF1_HUMAN
Tissue specificity: Present in various epithelial cells (at protein level)
genes like me logo Genes that share expressions with FBF1: view

In Situ Assay Products

Orthologs for FBF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBF1 35
  • 99.06 (n)
  • 98.32 (a)
FBF1 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBF1 35
  • 82.01 (n)
  • 77.39 (a)
FBF1 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBF1 35
  • 82.39 (n)
  • 76.91 (a)
FBF1 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbf1 35
  • 76.3 (n)
  • 67.44 (a)
Fbf1 16
Fbf1 36
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBF1 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBF1 36
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbf1 35
  • 76.55 (n)
  • 68.1 (a)
chicken
(Gallus gallus)
Aves FBF1 35
  • 63.68 (n)
  • 54.28 (a)
FBF1 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBF1 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbf1 35
  • 58.33 (n)
  • 52.87 (a)
zebrafish
(Danio rerio)
Actinopterygii FBF1 (1 of 2) 36
  • 38 (a)
OneToMany
FBF1 (2 of 2) 36
  • 42 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5964 36
  • 18 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToOne
Species with no ortholog for FBF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBF1 Gene

ENSEMBL:
Gene Tree for FBF1 (if available)
TreeFam:
Gene Tree for FBF1 (if available)

Paralogs for FBF1 Gene

No data available for Paralogs for FBF1 Gene

Variants for FBF1 Gene

Sequence variations from dbSNP and Humsavar for FBF1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs936398 -- 75,940,489(-) CACTT(A/G)AGGCC intron-variant
rs1058139 -- 75,929,129(-) cctgt(A/G)atccc intron-variant
rs1135806 -- 75,929,066(-) ctgca(A/G)tgagc intron-variant
rs1135889 - 75,930,040(+) AGATA(A/C)CTGAA reference, missense
rs2305913 - 75,926,860(-) CATTG(A/G)GAGGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FBF1 Gene

Variant ID Type Subtype PubMed ID
dgv3264n71 CNV Loss 21882294
dgv3267n71 CNV Loss 21882294
nsv833545 CNV Gain 17160897
nsv908820 CNV Loss 21882294
nsv908821 CNV Loss 21882294

Relevant External Links for FBF1 Gene

HapMap Linkage Disequilibrium report
FBF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBF1 Gene

Disorders for FBF1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for FBF1 Gene including...

Search for FBF1 Gene in MalaCards »

(2) University of Copenhagen DISEASES for FBF1 Gene

genes like me logo Genes that share disorders with FBF1: view

No data available for UniProtKB/Swiss-Prot for FBF1 Gene

Publications for FBF1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The keratin-binding protein Albatross regulates polarization of epithelial cells. (PMID: 18838552) Sugimoto M. … Inagaki M. (J. Cell Biol. 2008) 3 4
  4. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. (PMID: 21399614) Jakobsen L. … Andersen J.S. (EMBO J. 2011) 3 4
  5. Centriole distal appendages promote membrane docking, leading to cilia initiation. (PMID: 23348840) Tanos B.E. … Tsou M.F. (Genes Dev. 2013) 3 4

Products for FBF1 Gene

Sources for FBF1 Gene

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