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Aliases for FAXDC2 Gene

Aliases for FAXDC2 Gene

  • Fatty Acid Hydroxylase Domain Containing 2 2 3
  • C5orf4 3 4
  • Fatty Acid Hydroxylase Domain-Containing Protein 2 3
  • Chromosome 5 Open Reading Frame 4 2

External Ids for FAXDC2 Gene

Previous HGNC Symbols for FAXDC2 Gene

  • C5orf4

Previous GeneCards Identifiers for FAXDC2 Gene

  • GC05M154198

Summaries for FAXDC2 Gene

GeneCards Summary for FAXDC2 Gene

FAXDC2 (Fatty Acid Hydroxylase Domain Containing 2) is a Protein Coding gene. Among its related pathways are Metabolism and superpathway of cholesterol biosynthesis. GO annotations related to this gene include iron ion binding and oxidoreductase activity. An important paralog of this gene is CH25H.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAXDC2 Gene

Genomics for FAXDC2 Gene

Genomic Location for FAXDC2 Gene

Start:
154,817,034 bp from pter
End:
154,859,252 bp from pter
Size:
42,219 bases
Orientation:
Minus strand

Genomic View for FAXDC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAXDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAXDC2 Gene

No data available for Regulatory Elements for FAXDC2 Gene

Proteins for FAXDC2 Gene

  • Protein details for FAXDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IV6-FXDC2_HUMAN
    Recommended name:
    Fatty acid hydroxylase domain-containing protein 2
    Protein Accession:
    Q96IV6
    Secondary Accessions:
    • B4DIE1
    • Q9BSX6
    • Q9H8C7

    Protein attributes for FAXDC2 Gene

    Size:
    333 amino acids
    Molecular mass:
    39002 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAXDC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAXDC2 Gene

Proteomics data for FAXDC2 Gene at MOPED

Post-translational modifications for FAXDC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAXDC2 Gene

Domains for FAXDC2 Gene

Gene Families for FAXDC2 Gene

HGNC:
  • FATHD :Fatty acid hydroxylase domain containing

Protein Domains for FAXDC2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96IV6

UniProtKB/Swiss-Prot:

FXDC2_HUMAN :
  • Q96IV6
Family:
  • Belongs to the sterol desaturase family.
genes like me logo Genes that share domains with FAXDC2: view

No data available for Suggested Antigen Peptide Sequences for FAXDC2 Gene

Function for FAXDC2 Gene

Gene Ontology (GO) - Molecular Function for FAXDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with FAXDC2: view

Animal Model Products

CRISPR Products

miRNA for FAXDC2 Gene

miRTarBase miRNAs that target FAXDC2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAXDC2 Gene

Localization for FAXDC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAXDC2 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for FAXDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAXDC2: view

No data available for Subcellular locations from COMPARTMENTS for FAXDC2 Gene

Pathways for FAXDC2 Gene

genes like me logo Genes that share pathways with FAXDC2: view

Pathways by source for FAXDC2 Gene

2 KEGG pathways for FAXDC2 Gene

Interacting Proteins for FAXDC2 Gene

Gene Ontology (GO) - Biological Process for FAXDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006633 fatty acid biosynthetic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with FAXDC2: view

Transcripts for FAXDC2 Gene

Unigene Clusters for FAXDC2 Gene

Fatty acid hydroxylase domain containing 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAXDC2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FAXDC2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAXDC2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d · 9e · 9f ^ 10a · 10b · 10c ^
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - -
SP6: - - - - -
SP7: - -
SP8: - - - - - - - - - - - - -
SP9: -
SP10: - - -
SP11: - - - - -
SP12: - - - - -
SP13: -
SP14:

ExUns: 11 ^ 12a · 12b · 12c ^ 13
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: -

Relevant External Links for FAXDC2 Gene

GeneLoc Exon Structure for
FAXDC2
ECgene alternative splicing isoforms for
FAXDC2

Expression for FAXDC2 Gene

mRNA expression in normal human tissues for FAXDC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FAXDC2 Gene

SOURCE GeneReport for Unigene cluster for FAXDC2 Gene Hs.519694

genes like me logo Genes that share expressions with FAXDC2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAXDC2 Gene

Orthologs for FAXDC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FAXDC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAXDC2 35
  • 99.7 (n)
  • 99.4 (a)
FAXDC2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAXDC2 35
  • 90.89 (n)
  • 89.49 (a)
FAXDC2 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAXDC2 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAXDC2 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Faxdc2 35
  • 81.22 (n)
  • 77.4 (a)
chicken
(Gallus gallus)
Aves C13H5ORF4 35
  • 67.37 (n)
  • 63.96 (a)
FAXDC2 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAXDC2 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496051 35
  • 68.68 (n)
  • 66.77 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.8390 35
faxdc2 35
  • 67.6 (n)
  • 62.31 (a)
faxdc2 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000091 35
  • 56.3 (n)
  • 47.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1998 35
  • 55.69 (n)
  • 46.58 (a)
CG1998 36
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F49E12.9 35
  • 46.94 (n)
  • 38.95 (a)
F49E12.9 36
  • 39 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERG25 36
  • 20 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7976 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11249 36
  • 47 (a)
OneToOne
Species with no ortholog for FAXDC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAXDC2 Gene

ENSEMBL:
Gene Tree for FAXDC2 (if available)
TreeFam:
Gene Tree for FAXDC2 (if available)

Paralogs for FAXDC2 Gene

Paralogs for FAXDC2 Gene

genes like me logo Genes that share paralogs with FAXDC2: view

Variants for FAXDC2 Gene

Sequence variations from dbSNP and Humsavar for FAXDC2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs4865 -- 154,818,739(+) AAAAC(C/T)GTATC utr-variant-3-prime
rs32426 -- 154,821,949(-) ACCAC(A/G)CCTGG intron-variant
rs39614 -- 154,819,808(-) AAATC(A/G)TTATA utr-variant-3-prime
rs39952 -- 154,821,692(-) tggga(C/T)tacag intron-variant
rs42735 -- 154,821,740(-) ggaac(C/T)cctgg intron-variant

Relevant External Links for FAXDC2 Gene

HapMap Linkage Disequilibrium report
FAXDC2
Human Gene Mutation Database (HGMD)
FAXDC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAXDC2 Gene

Disorders for FAXDC2 Gene

No disorders were found for FAXDC2 Gene.

No data available for UniProtKB/Swiss-Prot for FAXDC2 Gene

Publications for FAXDC2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Transcription mapping of the 5q- syndrome critical region: cloning of two novel genes and sequencing, expression, and mapping of a further six novel cDNAs. (PMID: 10843801) Boultwood J. … Wainscoat J.S. (Genomics 2000) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3

Products for FAXDC2 Gene

Sources for FAXDC2 Gene

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