FAXC Gene
protein-coding GIFtS: 38
GCID: GC06M099720
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failed axon connections homolog (Drosophila)(Previous name: chromosome 6 open reading frame 168 )
(Previous symbol: C6orf168)
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Aliases
for FAXC gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Failed Axon Connections Homolog (Drosophila)1 2 | | C6orf1681 2 3 | | DJ273F201 | | MGC28171 | | Chromosome 6 Open Reading Frame 1681 | | Failed Axon Connections Homolog2 |
Export aliases for FAXC gene to outside databases |
Summaries
for FAXC gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FAXC_HUMAN, Q5TGI0Function: May play a role in axonal development (By similarity)
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Genomic Views
for FAXC gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for FAXC
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAXC
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAXC |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q16.2 Ensembl cytogenetic band: 6q16.2 HGNC cytogenetic band: 6q16.3FAXC Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M099720: view genomic region
(about GC identifiers)
Start:
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99,720,793 bp from pter |
End:
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99,797,938 bp from pter |
Size:
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77,146 bases |
Orientation:
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minus strand |
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Proteins
for FAXC gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FAXC_HUMAN, Q5TGI0 (See
protein sequence)Recommended Name: Failed axon connections homolog Size: 409 amino acids; 46843 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=BAB71576.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B3KU39 Q96F61 Q96LU3 Q9BSS2Explore the universe of human proteins at neXtProt for FAXC: NX_Q5TGI0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5TGI0
FAXC Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115900.1
ENSEMBL proteins: ENSP00000374328 ENSP00000445267
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
FAXC for ontologies About GeneDecksing
FAXC Antibody Products:
Assay Products for FAXC: |
Protein
Domains /
Families
for FAXC gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAXC for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5TGI0ProtoNet protein and cluster: Q5TGI0 UniProtKB/Swiss-Prot: FAXC_HUMAN, Q5TGI0Similarity: Belongs to the FAX family |
Function
for FAXC gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FAXC_HUMAN, Q5TGI0Function: May play a role in axonal development (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAXC (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAXC
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for FAXC | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAXC | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAXC |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAXC |
1 GenomeRNAi human phenotype for FAXC:
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Pathways & Interactions
for FAXC gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAXC
|
Drugs & Compounds
for FAXC gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAXC
Search CenterWatch for drugs/clinical trials and news about FAXC
|
Transcripts
for FAXC gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAXC gene: NM_032511.2 Unigene Cluster for FAXC: Failed axon connections homolog (Drosophila) Hs.573245 [show with all ESTs]Unigene Representative Sequence: NM_0325114 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000389677(uc003ppi.4 uc003ppj.4) ENST00000461803 ENST00000480148
ENST00000538471
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAXC (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAXC
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for FAXC | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAXC | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAXC |
Additional cDNA sequence: AK055101.1 AK057793.1 AK096480.1 BC004869.2 BC006515.2 BC011583.1 CR749795.1 10 DOTS entries: DT.70103961 DT.210391 DT.100748336 DT.406736 DT.95071499 DT.121332242 DT.403212 DT.95346470 DT.99931423 DT.91743007 24/70 AceView cDNA sequences (see all 70): BU689259 Z44156 BF448187 BF592825 F10293 BC004869 BC006515 BC011583 NM_032511 AI630979 F12682 BQ883579 CK905045 BI113852 Z40147 CD513131 BQ067826 AI669373 BG190866 AI468796 BG828811 AK057793 AK096480 CK299578
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FAXC (see all 6) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | |
ECgene alternative splicing isoforms for FAXC
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Expression
for FAXC gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAXC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTTTTTTTC
About this image
See FAXC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAXC
SOURCE GeneReport for Unigene cluster: Hs.573245
SABiosciences Custom PCR Arrays for FAXC
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAXC
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat FAXC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAXC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAXC | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAXC |
Orthologs
for FAXC gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FAXC gene from 6/17 species (see all 17) About this table
ENSEMBL Gene Tree for FAXC (if available)
TreeFam Gene Tree for FAXC (if available) |
Paralogs
for FAXC gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for FAXC gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAXC (99720793 - 99797938 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAXC: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAXC |
|
Disorders
/ Diseases
for FAXC gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FAXC gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAXC gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAXC) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for FAXC gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing FAXC gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAXC gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAXC gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAXC | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for FAXC gene:
Search GeneIP for patents involving FAXC
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAXC gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAXC | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAXC | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAXC | | | OriGene Protein Over-expression Lysate for FAXC | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAXC | | OriGene 3'-UTR Clone for FAXC | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAXC | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAXC | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FAXC | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAXC | | OriGene Custom Protein Services for FAXC | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAXC | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAXC | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAXC | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAXC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAXC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAXC |
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 |  |  |  | |
| | | | Search Tocris compounds for FAXC |
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 | | | FAXC Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAXC |
|  |  |  | | | | Search ThermoFisher Antibodies for FAXC |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAXC |
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