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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAXC Gene

protein-coding   GIFtS: 36
GCID: GC06M099720

Failed Axon Connections Homolog (Drosophila)

(Previous name: chromosome 6 open reading frame 168)
(Previous symbol: C6orf168)
  Search for FAXC
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Failed Axon Connections Homolog (Drosophila)1 2
C6orf1681 2 3
Chromosome 6 Open Reading Frame 1681
dJ273F202
Failed Axon Connections Homolog2

External Ids:    HGNC: 207421   Entrez Gene: 845532   Ensembl: ENSG000001462677   UniProtKB: Q5TGI03   

Export aliases for FAXC gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAXC Gene: 
FAXC (failed axon connections homolog (Drosophila)) is a protein-coding gene.

UniProtKB/Swiss-Prot: FAXC_HUMAN, Q5TGI0
Function: May play a role in axonal development (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for FAXC
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FAXC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAXC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q16.2   Ensembl cytogenetic band:  6q16.2   HGNC cytogenetic band: 6q16.3

FAXC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAXC gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M099720:  view genomic region     (about GC identifiers)

Start:
99,719,045 bp from pter      End:
99,797,938 bp from pter
Size:
78,894 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FAXC_HUMAN, Q5TGI0 (See protein sequence)
Recommended Name: Failed axon connections homolog  
Size: 409 amino acids; 46843 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=BAB71576.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B3KU39 Q96F61 Q96LU3 Q9BSS2

Explore the universe of human proteins at neXtProt for FAXC: NX_Q5TGI0

Explore proteomics data for FAXC at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5TGI0

  • FAXC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAXC Protein Expression
    REFSEQ proteins: NP_115900.1  
    ENSEMBL proteins: 
     ENSP00000374328   ENSP00000445267  

    Human Recombinant Protein Products for FAXC: 
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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    FAXC for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR012336 Thioredoxin-like_fold
     IPR026928 FAX
     IPR010987 Glutathione-S-Trfase_C-like

    Graphical View of Domain Structure for InterPro Entry Q5TGI0

    ProtoNet protein and cluster: Q5TGI0

    UniProtKB/Swiss-Prot: FAXC_HUMAN, Q5TGI0
    Similarity: Belongs to the FAX family


    FAXC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FAXC_HUMAN, Q5TGI0
    Function: May play a role in axonal development (By similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for FAXC:

     Increased gamma-H2AX phosphory 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAXC

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAXC

    Search CenterWatch for drugs/clinical trials and news about FAXC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAXC gene: 
    NM_032511.2  

    Unigene Cluster for FAXC:

    Failed axon connections homolog (Drosophila)
    Hs.573245  [show with all ESTs]
    Unigene Representative Sequence: NM_032511
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000389677(uc003ppi.4 uc003ppj.4) ENST00000461803 ENST00000480148
    ENST00000538471
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK055101.1 AK057793.1 AK096480.1 BC004869.2 BC006515.2 BC011583.1 CR749795.1 

    10 DOTS entries:

    DT.70103961  DT.210391  DT.100748336  DT.406736  DT.95071499  DT.121332242  DT.403212  DT.95346470 
    DT.99931423  DT.91743007 

    24/70 AceView cDNA sequences (see all 70):

    BC011583 Z44156 NM_032511 BC006515 BF592825 AI630979 BQ883579 F12682 
    BF448187 BU689259 CK905045 F10293 BC004869 Z40147 AI378536 AK096480 
    CR749795 BM724345 BQ189447 AW583091 BG828811 AK057793 AA253386 AI669373 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FAXC (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
    SP1:                                                                                    
    SP2:        -     -     -     -                                                         
    SP3:                    -     -                                                         
    SP4:                    -     -     -                                                   
    SP5:                                                              -     -               


    ECgene alternative splicing isoforms for FAXC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAXC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTTTTTTC
    FAXC Expression
    About this image


    See FAXC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAXC

    SOURCE GeneReport for Unigene cluster: Hs.573245
        SABiosciences Custom PCR Arrays for FAXC
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAXC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FAXC gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Faxc1 , 5 RIKEN cDNA 6230409E13 gene5
    failed axon connections homolog (Drosophila)1
    93.4(n)1
    98.53(a)1
      4 (9.20 cM)5
    761321  NM_175234.41  NP_780443.21 
     219313295 
    chicken
    (Gallus gallus)
    Aves C3H6orf1681 chromosome 3 open reading frame, human C6orf168 78.96(n)
    83.66(a)
      428630  XM_426188.3  XP_426188.3 
    lizard
    (Anolis carolinensis)
    Reptilia FAXC6
    Uncharacterized protein
    77(a)
    1 ↔ 1
    1(171868531-171903374)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5637961 uncharacterized protein C6orf168-like 70.18(n)
    68.42(a)
      563796  XM_687158.3  XP_692250.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta fax6
    failed axon connections
    22(a)
    1 ↔ 1
    3L(16395896-16404939)
    worm
    (Caenorhabditis elegans)
    Secernentea Y57A10A.266
    Y48C3A.36
    (see all 10)
    Protein Y48C3A.3
    (see all 10)
    32(a)
    28(a)
    (see all 10)
    many → 1
    many → 1
    (see all 10)
    II(12264166-12266105)
    II(13309290-13311479)


    ENSEMBL Gene Tree for FAXC (if available)
    TreeFam Gene Tree for FAXC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1539 SNPs in FAXC are shown (see all 1539)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs710217211,2
    C--97203300(-) TACTG-/GTTT  
            
    TTTTT
    1 -- int11Minor allele frequency- GTTT:0.00NA 2
    rs1826838541,2
    --99720300(+) CCCACC/GTTGGC 1 -- ds50010--------
    rs1860253501,2
    --99720333(+) GGCATA/GAGCCA 1 -- ds50010--------
    rs1180068771,2
    C,F--99720428(+) GTGCTC/TCCAGC 1 -- ds50011Minor allele frequency- T:0.02NA 120
    rs560203591,2
    C,F--99720447(+) TCCTCC/GTTGTC 1 -- ds50011Minor allele frequency- G:0.04NA 120
    rs1492911841,2
    --99720481(+) ACTTCA/GTAACA 1 -- ds50010--------
    rs10457321,2
    C,F,H--99720838(-) TTAATG/ACTATA 1 -- ut317Minor allele frequency- A:0.11NS NA CSA WA EA 592
    rs1445653371,2
    C--99720937(+) AAATAC/TGGCTT 1 -- ut310--------
    rs10457311,2
    C,F,A,H--99721003(-) AGATGG/ACATTT 1 -- ut3128Minor allele frequency- A:0.48MN NA NS EA WA CSA 2676
    rs10457281,2
    C,F,A,H--99721049(-) GCAATC/TACAAT 1 -- ut3141Minor allele frequency- T:0.45MN EA NA NS WA CSA 3962

    HapMap Linkage Disequilibrium report for FAXC (99719045 - 99797938 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FAXC: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FAXC
    DNA2.0 Custom Variant and Variant Library Synthesis for FAXC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAXC gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FAXC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84553 HGNC: 20742 AceView: C6orf168 Ensembl:ENSG00000146267 euGenes: HUgn84553
    ECgene: FAXC H-InvDB: FAXC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAXC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAXC gene:
    Search GeneIP for patents involving FAXC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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