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Aliases for FAXC Gene

Aliases for FAXC Gene

  • Failed Axon Connections Homolog (Drosophila) 2 3
  • C6orf168 3 4
  • Chromosome 6 Open Reading Frame 168 2
  • Failed Axon Connections Homolog 3
  • DJ273F20 3

External Ids for FAXC Gene

Previous HGNC Symbols for FAXC Gene

  • C6orf168

Previous GeneCards Identifiers for FAXC Gene

  • GC06M099720

Summaries for FAXC Gene

GeneCards Summary for FAXC Gene

FAXC (Failed Axon Connections Homolog (Drosophila)) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FAXC Gene

  • May play a role in axonal development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAXC Gene

Genomics for FAXC Gene

Genomic Location for FAXC Gene

99,271,169 bp from pter
99,350,062 bp from pter
78,894 bases
Minus strand

Genomic View for FAXC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAXC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAXC Gene

No data available for Regulatory Elements for FAXC Gene

Proteins for FAXC Gene

  • Protein details for FAXC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Failed axon connections homolog
    Protein Accession:
    Secondary Accessions:
    • B3KU39
    • Q96F61
    • Q96LU3
    • Q9BR58
    • Q9BSS2

    Protein attributes for FAXC Gene

    409 amino acids
    Molecular mass:
    46843 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB71576.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAXC Gene


neXtProt entry for FAXC Gene

Proteomics data for FAXC Gene at MOPED

Post-translational modifications for FAXC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAXC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAXC Gene

Domains for FAXC Gene

Protein Domains for FAXC Gene

Graphical View of Domain Structure for InterPro Entry



  • Q5TGI0
  • Belongs to the FAX family.
genes like me logo Genes that share domains with FAXC: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for FAXC Gene

Function for FAXC Gene

Molecular function for FAXC Gene

UniProtKB/Swiss-Prot Function:
May play a role in axonal development.

Phenotypes for FAXC Gene

GenomeRNAi human phenotypes for FAXC:
genes like me logo Genes that share phenotypes with FAXC: view

Animal Model Products

CRISPR Products

miRNA for FAXC Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAXC

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAXC Gene

Localization for FAXC Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAXC Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for FAXC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAXC: view

No data available for Subcellular locations from COMPARTMENTS for FAXC Gene

Pathways for FAXC Gene

SuperPathways for FAXC Gene

No Data Available

Interacting Proteins for FAXC Gene

Gene Ontology (GO) - Biological Process for FAXC Gene


No data available for Pathways by source for FAXC Gene

Transcripts for FAXC Gene

Unigene Clusters for FAXC Gene

Failed axon connections homolog (Drosophila):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAXC

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAXC Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - - - -

Relevant External Links for FAXC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAXC Gene

mRNA expression in normal human tissues for FAXC Gene

mRNA differential expression in normal tissues according to GTEx for FAXC Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (4.8).

Protein differential expression in normal tissues for FAXC Gene

This gene is overexpressed in Heart (60.4) and Colon (7.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FAXC Gene

SOURCE GeneReport for Unigene cluster for FAXC Gene Hs.573245

genes like me logo Genes that share expressions with FAXC: view

Expression partners for FAXC Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAXC Gene

Orthologs for FAXC Gene

This gene was present in the common ancestor of animals.

Orthologs for FAXC Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAXC 35
  • 93.96 (n)
  • 99.69 (a)
  • 100 (a)
(Canis familiaris)
Mammalia FAXC 35
  • 96.17 (n)
  • 99.51 (a)
  • 100 (a)
(Mus musculus)
Mammalia Faxc 35
  • 93.4 (n)
  • 98.53 (a)
Faxc 16
Faxc 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Faxc 35
  • 93.48 (n)
  • 98.78 (a)
(Monodelphis domestica)
Mammalia FAXC 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia FAXC 36
  • 90 (a)
(Pan troglodytes)
Mammalia FAXC 36
  • 100 (a)
(Gallus gallus)
Aves C6ORF168 35
  • 79.04 (n)
  • 83.66 (a)
  • 82 (a)
(Anolis carolinensis)
Reptilia FAXC 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia faxc 35
  • 77.91 (n)
  • 83.25 (a)
(Danio rerio)
Actinopterygii FAXC (1 of 2) 36
  • 67 (a)
faxcb 36
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta fax 36
  • 21 (a)
(Caenorhabditis elegans)
Secernentea CELE_Y57A10A.26 35
  • 47.84 (n)
  • 36.64 (a)
C25H3.7 36
  • 26 (a)
cdr-1 36
  • 25 (a)
cdr-2 36
  • 24 (a)
cdr-3 36
  • 23 (a)
cdr-4 36
  • 24 (a)
cdr-6 36
  • 25 (a)
cdr-7 36
  • 26 (a)
hrg-2 36
  • 27 (a)
Y48C3A.3 36
  • 29 (a)
Y57A10A.26 36
  • 31 (a)
Species with no ortholog for FAXC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAXC Gene

Gene Tree for FAXC (if available)
Gene Tree for FAXC (if available)

Paralogs for FAXC Gene

No data available for Paralogs for FAXC Gene

Variants for FAXC Gene

Sequence variations from dbSNP and Humsavar for FAXC Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs16635 -- 99,341,899(-) GTTAT(-/CAT)TTTTA intron-variant
rs126849 -- 99,326,658(-) CTAGA(A/G)ACTTC intron-variant, upstream-variant-2KB
rs126850 -- 99,326,566(-) AACCT(A/G)TCTCC intron-variant, upstream-variant-2KB
rs126851 -- 99,325,676(-) GGGAA(C/T)GTGAA intron-variant
rs126854 -- 99,301,656(-) AGGAG(G/T)ATTCT intron-variant

Relevant External Links for FAXC Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAXC Gene

Disorders for FAXC Gene

No disorders were found for FAXC Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FAXC Gene

Publications for FAXC Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A genome-wide association study of behavioral disinhibition. (PMID: 23942779) McGue M. … Iacono W.G. (Behav. Genet. 2013) 3

Products for FAXC Gene

Sources for FAXC Gene

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