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Aliases for FAXC Gene

Aliases for FAXC Gene

  • Failed Axon Connections Homolog 2 3 5
  • C6orf168 3 4
  • Failed Axon Connections Homolog (Drosophila) 2
  • Chromosome 6 Open Reading Frame 168 2
  • DJ273F20 3

External Ids for FAXC Gene

Previous HGNC Symbols for FAXC Gene

  • C6orf168

Previous GeneCards Identifiers for FAXC Gene

  • GC06M099720

Summaries for FAXC Gene

GeneCards Summary for FAXC Gene

FAXC (Failed Axon Connections Homolog) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FAXC Gene

  • May play a role in axonal development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAXC Gene

Genomics for FAXC Gene

Regulatory Elements for FAXC Gene

Enhancers for FAXC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around FAXC on UCSC Golden Path with GeneCards custom track

Promoters for FAXC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for FAXC Gene

99,271,169 bp from pter
99,350,122 bp from pter
78,954 bases
Minus strand

Genomic View for FAXC Gene

Genes around FAXC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAXC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAXC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAXC Gene

Proteins for FAXC Gene

  • Protein details for FAXC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Failed axon connections homolog
    Protein Accession:
    Secondary Accessions:
    • B3KU39
    • Q96F61
    • Q96LU3
    • Q9BR58
    • Q9BSS2

    Protein attributes for FAXC Gene

    409 amino acids
    Molecular mass:
    46843 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB71576.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAXC Gene


neXtProt entry for FAXC Gene

Post-translational modifications for FAXC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAXC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAXC Gene

Domains & Families for FAXC Gene

Protein Domains for FAXC Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAX family.
  • Belongs to the FAX family.
genes like me logo Genes that share domains with FAXC: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for FAXC Gene

Function for FAXC Gene

Molecular function for FAXC Gene

UniProtKB/Swiss-Prot Function:
May play a role in axonal development.
genes like me logo Genes that share phenotypes with FAXC: view

Animal Model Products

CRISPR Products

miRNA for FAXC Gene

miRTarBase miRNAs that target FAXC

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAXC Gene

Localization for FAXC Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAXC Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for FAXC Gene COMPARTMENTS Subcellular localization image for FAXC gene
Compartment Confidence
endoplasmic reticulum 2
mitochondrion 2
nucleus 2
cytosol 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FAXC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAXC: view

Pathways & Interactions for FAXC Gene

SuperPathways for FAXC Gene

No Data Available

Interacting Proteins for FAXC Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)
Selected Interacting proteins: ENSP00000374328 Q5TGI0-FAXC_HUMAN for FAXC Gene via STRING IID

Gene Ontology (GO) - Biological Process for FAXC Gene


No data available for Pathways by source and SIGNOR curated interactions for FAXC Gene

Drugs & Compounds for FAXC Gene

No Compound Related Data Available

Transcripts for FAXC Gene

Unigene Clusters for FAXC Gene

Failed axon connections homolog (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAXC Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - - - -

Relevant External Links for FAXC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAXC Gene

mRNA expression in normal human tissues for FAXC Gene

mRNA differential expression in normal tissues according to GTEx for FAXC Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.8).

Protein differential expression in normal tissues from HIPED for FAXC Gene

This gene is overexpressed in Heart (60.4) and Colon (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAXC Gene

Protein tissue co-expression partners for FAXC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAXC Gene:


SOURCE GeneReport for Unigene cluster for FAXC Gene:

genes like me logo Genes that share expression patterns with FAXC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAXC Gene

Orthologs for FAXC Gene

This gene was present in the common ancestor of animals.

Orthologs for FAXC Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAXC 34
  • 93.96 (n)
  • 99.69 (a)
  • 100 (a)
(Canis familiaris)
Mammalia FAXC 34
  • 96.17 (n)
  • 99.51 (a)
  • 100 (a)
(Mus musculus)
Mammalia Faxc 34
  • 93.4 (n)
  • 98.53 (a)
Faxc 16
Faxc 35
  • 99 (a)
(Rattus norvegicus)
Mammalia Faxc 34
  • 93.48 (n)
  • 98.78 (a)
(Monodelphis domestica)
Mammalia FAXC 35
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia FAXC 35
  • 90 (a)
(Pan troglodytes)
Mammalia FAXC 35
  • 100 (a)
(Gallus gallus)
Aves C6ORF168 34
  • 79.04 (n)
  • 83.66 (a)
  • 82 (a)
(Anolis carolinensis)
Reptilia FAXC 35
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia faxc 34
  • 77.91 (n)
  • 83.25 (a)
(Danio rerio)
Actinopterygii FAXC (1 of 2) 35
  • 67 (a)
faxcb 35
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta fax 35
  • 21 (a)
(Caenorhabditis elegans)
Secernentea CELE_Y57A10A.26 34
  • 47.84 (n)
  • 36.64 (a)
C25H3.7 35
  • 26 (a)
cdr-1 35
  • 25 (a)
cdr-2 35
  • 24 (a)
cdr-3 35
  • 23 (a)
cdr-4 35
  • 24 (a)
cdr-6 35
  • 25 (a)
cdr-7 35
  • 26 (a)
hrg-2 35
  • 27 (a)
Y48C3A.3 35
  • 29 (a)
Y57A10A.26 35
  • 31 (a)
Species where no ortholog for FAXC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAXC Gene

Gene Tree for FAXC (if available)
Gene Tree for FAXC (if available)

Paralogs for FAXC Gene

No data available for Paralogs for FAXC Gene

Variants for FAXC Gene

Sequence variations from dbSNP and Humsavar for FAXC Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs910034 -- 99,276,837(-) TAATC(C/T)AACGA utr-variant-3-prime
rs910036 -- 99,275,886(-) CCTTG(G/T)TGGGT utr-variant-3-prime
rs910037 -- 99,275,678(-) TTGCC(A/T)GTTAG utr-variant-3-prime
rs983455 -- 99,310,315(-) GGCAC(A/C/T)GTGCC intron-variant
rs983523 -- 99,278,745(-) GGGCA(A/G)TTGCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FAXC Gene

Variant ID Type Subtype PubMed ID
esv3449999 CNV insertion 20981092
nsv1029536 CNV loss 25217958
nsv1112903 CNV deletion 24896259

Variation tolerance for FAXC Gene

Residual Variation Intolerance Score: 29.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAXC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAXC Gene

Disorders for FAXC Gene

Relevant External Links for FAXC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAXC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAXC Gene

Publications for FAXC Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 65
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 65

Products for FAXC Gene

Sources for FAXC Gene

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