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FAU Gene

protein-coding   GIFtS: 63
GCID: GC11M064888

Finkel-Biskis-Reilly Murine Sarcoma Virus (FBR-MuSV) Ubiquitously...

(Previous name: Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously...)
  See FAU-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4

Aliases
Finkel-Biskis-Reilly Murine Sarcoma Virus (FBR-MuSV) Ubiquitously
Expressed1 2
     MNSFbeta2
Finkel-Biskis-Reilly Murine Sarcoma Virus (FBR-MuSV) Ubiquitously
Expressed (Fox Derived)1 2
     RPS302
Monoclonal Nonspecific Suppressor Factor Beta1 2     S302
Ribosomal Protein S301 2     asr12
40S Ribosomal Protein S302     FAU-Encoded Ubiquitin-Like Protein2
FAU12     FBR-MuSV-Associated Ubiquitously Expressed2
Fub12     Ubiquitin-Like Protein Fubi And Ribosomal Protein S302
Fubi2     Ubiquitin-Like-S30 Fusion Protein2

External Ids:    HGNC: 35971   Entrez Gene: 21972   Ensembl: ENSG000001498067   OMIM: 1346905   UniProtKB: P628613   
UniProtKB: P355443   
ORGUL members:    fRNAdb10:FR280485      
H-InvDB12:HIT000101232    
NCBI13:D28403    
RNAdb15:HIV1554    

Export aliases for FAU gene to outside databases

Previous GC identifers: GC11M067403 GC11M066569 GC11M065138 GC11M064663 GC11M064644 GC11M061214


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FAU Gene:
This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV).
It encodes a fusion protein consisting of the ubiquitin-like protein fubi at the N terminus and ribosomal protein
S30 at the C terminus. It has been proposed that the fusion protein is post-translationally processed to generate
free fubi and free ribosomal protein S30. Fubi is a member of the ubiquitin family, and ribosomal protein S30
belongs to the S30E family of ribosomal proteins. Whereas the function of fubi is currently unknown, ribosomal
protein S30 is a component of the 40S subunit of the cytoplasmic ribosome. Pseudogenes derived from this gene are
present in the genome. Similar to ribosomal protein S30, ribosomal proteins S27a and L40 are synthesized as
fusion proteins with ubiquitin. (provided by RefSeq, Jul 2008)

GeneCards Summary for FAU Gene:
FAU (Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed) is a protein-coding gene. Diseases associated with FAU include sarcoma. GO annotations related to this gene include structural constituent of ribosome and RNA binding. An important paralog of this gene is LOC101927789.

Gene Wiki entry for FAU Gene

fRNAdb sequence ontology for FAU:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for FAU

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAU gene promoter:
         GR   AP-1   GR-beta   ATF-2   FOXO4   c-Jun   GR-alpha   ATF6   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAU promoter sequence
   Search Chromatin IP Primers for FAU

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAU


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13

FAU Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAU gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M064888:  view genomic region     (about GC identifiers)

Start:
64,888,099 bp from pter      End:
64,889,945 bp from pter
Size:
1,847 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RS30_HUMAN, P62861 (See protein sequence)
Recommended Name: 40S ribosomal protein S30  
Size: 59 amino acids; 6648 Da
Miscellaneous: This ribosomal protein is synthesized as a C-terminal extension protein (CEP) of a ubiquitin-like
protein
Sequence caution: Sequence=AAH33877.1; Type=Erroneous initiation; Sequence=AAQ87877.1; Type=Erroneous initiation;
Sequence=BAB15515.1; Type=Erroneous initiation; Sequence=CAA46714.1; Type=Erroneous initiation;
Sequence=CAA46716.1; Type=Erroneous initiation; Sequence=CAG46772.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for FAU:
3J3A (3D)    
Secondary accessions: Q05472 Q95261 Q9H5V4

UniProtKB/Swiss-Prot: UBIM_HUMAN, P35544 (See protein sequence)

Recommended Name: Ubiquitin-like protein FUBI  
Size: 74 amino acids; 7760 Da
Miscellaneous: This protein is synthesized with ribosomal S30 as its C-terminal extension
1 PDB 3D structure from and Proteopedia for FAU:
2L7R (3D)    
Secondary accessions: Q9H5V4

Explore the universe of human proteins at neXtProt for FAU: NX_P35544

Explore proteomics data for FAU at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAU Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001988.1  
    ENSEMBL proteins: 
     ENSP00000435370   ENSP00000431822   ENSP00000436110   ENSP00000434440   ENSP00000279259  
     ENSP00000434680   ENSP00000433139   ENSP00000413848  
    Reactome Protein details: P62861

    FAU Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for FAU (FUBI/MNSF beta)
    Enzo Life Sciences proteins for FAU
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    OriGene Protein Over-expression Lysate for FAU
    OriGene MassSpec for FAU
    OriGene Custom Protein Services for FAU
    GenScript Custom Purified and Recombinant Proteins Services for FAU
    Novus Biologicals FAU Proteins
    Novus Biologicals FAU Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for FAU 

     
    antibodies-online proteins for FAU (18 products) 

     
    antibodies-online peptides for FAU

    FAU Antibody Products:

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    Abcam antibodies for FAU (P35544, P62861)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for FAU
    antibodies-online antibodies for FAU (51 products) 

    FAU Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for FAU
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for FAU 
    antibodies-online kits for FAU (27 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RPS: S ribosomal proteins

    4 InterPro protein domains:
     IPR006846 Ribosomal_S30
     IPR019954 Ubiquitin_CS
     IPR000626 Ubiquitin_dom
     IPR019956 Ubiquitin

    Graphical View of Domain Structure for InterPro Entry P62861
    Graphical View of Domain Structure for InterPro Entry P35544

    ProtoNet protein and cluster: P62861

    UniProtKB/Swiss-Prot: RS30_HUMAN, P62861
    Similarity: Belongs to the ribosomal protein S30e family

    UniProtKB/Swiss-Prot: UBIM_HUMAN, P35544
    Similarity: Belongs to the ubiquitin family


    Find genes that share domains with FAU           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for FAU:
    Finkel-Biskis-Reilly (FBR)-murine sarcoma virus associated,ubiquitously expressed,viral FOX homolog

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003723RNA binding TAS8395683
    GO:0003735structural constituent of ribosome IDA15883184
    GO:0005515protein binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with FAU           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for FAU:
     Decreased G3BP1 protein expres  Decreased TP53 protein express  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 
     Decreased viability of wild-ty  Increased cell number in G1, s  Nucleolar pre-40S maturation d 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FAU

    miRNA
    Products:
        
    miRTarBase miRNAs that target FAU:
    hsa-mir-484 (MIRT041640), hsa-mir-140-3p (MIRT038648), hsa-mir-92a-3p (MIRT049781), hsa-mir-23a-3p (MIRT050429)

    Block miRNA regulation of human, mouse, rat FAU using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FAU
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FAU
    Predesigned siRNA for gene silencing in human, mouse, rat FAU

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FAU

    Clone
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    OriGene clones in human, mouse for FAU (see all 8)
    OriGene ORF clones in mouse, rat for FAU
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAU (NM_001997)
    Sino Biological Human cDNA Clone for FAU
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAU
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAU

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FAU
    Browse ESI BIO Cell Lines and PureStem Progenitors for FAU 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAU


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus3

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005840ribosome ----
    GO:0015935small ribosomal subunit IDA15883184

    Find genes that share ontologies with FAU           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FAU About   (see all 7)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CFTR translational fidelity class I mutations
    CFTR translational fidelity class I mutations 0.60
    Ribosome0.54
    Cytoplasmic Ribosomal Proteins0.60
    2Influenza Viral RNA Transcription and Replication
    Viral mRNA Translation0.94
    Eukaryotic Translation Initiation0.89
    Peptide chain elongation0.94
    Cap-dependent Translation Initiation0.89
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Formation of a pool of free 40S subunits0.94
    Nonsense-Mediated Decay0.89
    3Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    Translation initiation complex formation0.91
    Ribosomal scanning and start codon recognition0.91
    Formation of the ternary complex, and subsequently, the 43S complex0.91
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.90
    4Gene Expression
    Gene Expression0.40
    5Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with FAU           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for FAU
        CFTR translational fidelity (class I mutations)

    2 BioSystems Pathways for FAU
        Integrated Breast Cancer Pathway
    Cytoplasmic Ribosomal Proteins


    Selected Reactome Pathways for FAU (see all 12)
        Peptide chain elongation
    Formation of the ternary complex, and subsequently, the 43S complex
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit


    1 Kegg Pathway  (Kegg details for FAU):
        Ribosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAU
    Interactions:

        Search GeneGlobe Interaction Network for FAU

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FAU (P355442, 3 ENSP000002792594 P628612, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 327)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RETP079492, ENSP000003479424MINT-60966 MINT-60965 STRING: ENSP00000347942
    COPS6Q7L5N12, ENSP000003041024MINT-63691 STRING: ENSP00000304102
    MAP3K14Q995582MINT-48820
    DDOSTENSP000003641884STRING: ENSP00000364188
    EEF2ENSP000003079404STRING: ENSP00000307940
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006414translational elongation TAS--
    GO:0006415translational termination TAS--

    Find genes that share ontologies with FAU           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAU (UBIM)

    1 Novoseek inferred chemical compound relationship for FAU gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arsenite 54.2 1 10069470 (1)



    Find genes that share compounds with FAU           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for FAU gene: 
    NM_001997.4  

    Unigene Cluster for FAU:

    Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
    Hs.387208  [show with all ESTs]
    Unigene Representative Sequence: BM911491
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000529639(uc001ocx.3) ENST00000531743 ENST00000525297 ENST00000527548
    ENST00000531357 ENST00000279259 ENST00000529259 ENST00000526555 ENST00000434372

    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FAU
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAU (NM_001997)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAU
    Primer
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    OriGene qPCR primer pairs and template standards for FAU
    OriGene qSTAR qPCR primer pairs in human, mouse for FAU
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAU
      QuantiTect SYBR Green Assays in human, mouse, rat FAU
      Search QuantiFast Probe-based Assays in human, mouse, rat FAU

    Additional mRNA sequence: 

    AK026639.1 BC033877.1 CR541974.1 X65923.1 

    Selected DOTS entries (see all 28):

    DT.97761874  DT.100714868  DT.95316561  DT.101987486  DT.95174284  DT.91687819  DT.100727645  DT.95172595 
    DT.91772688  DT.87005531  DT.95172592  DT.120709024  DT.100714838  DT.100714864  DT.101987963  DT.120709010 
    DT.91772689  DT.97761870  DT.100714859  DT.101987166  DT.120709129  DT.91772658  DT.120709040  DT.120709046 

    Selected AceView cDNA sequences (see all 1565):

    AW204418 BC013860 N95755 D28403 BP369242 AI143620 BM825324 CD672934 
    BQ071795 BU856636 N40859 BE909324 AI339108 N62767 BU902417 AA907790 
    AI342048 NM_014205 CF147458 CB162862 BI712456 AA320766 AA401011 BE315154 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAU expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTCCCTGGC
    FAU Expression
    About this image


    FAU expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Ovary (Reproductive System)
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    FAU Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAU Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.387208
        Custom PCR Arrays for FAU
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FAU
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    Search QuantiFast Probe-based Assays in human, mouse, rat FAU
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAU

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FAU gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fau1 , 5 Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) more1, 5 91.48(n)1
    97.74(a)1
      19 (4.34 cM)5
    141091  NM_007990.31  NP_032016.11 
     60578885 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    83(a)
    1 → many
    GL344606.1(8966-12824)
    African clawed frog
    (Xenopus laevis)
    Amphibia BG552281.12   -- 76.86(n)    BG552281.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc731712 40S ribosomal protein S30 76.89(n)   393710  BC059522.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpS301 Ribosomal protein S30 63.28(n)
    59.37(a)
      42470  NM_142665.2  NP_650922.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rps-301 rps-30 58.07(n)
    56.25(a)
      179154  NM_072606.4  NP_505007.1 
    Alicante grape
    (Vitis vinifera)
    eudicotyledons CB003420.12   -- 79.02(n)    CB003420.1 
    rice
    (Oryza sativa)
    Liliopsida BE039801.12   -- 78.94(n)    BE039801.1 


    ENSEMBL Gene Tree for FAU (if available)
    TreeFam Gene Tree for FAU (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAU gene
    LOC1019277892  
    8 SIMAP similar genes for FAU using alignment to 6 protein entries:     RS30_HUMAN (see all proteins):
    LOC101927789    UBA52    DKFZp434K0435    UBB    UBBP4    UBC
    UbC    RPS27A

    Find genes that share paralogs with FAU           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for FAU
    PGOHUM00000249930 PGOHUM00000237883 PGOHUM00000258194 PGOHUM00000241951


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    3 SNPs for FAU    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs93335821,2
    C,F,H--64887616(-) TGGCCG/AGACTT 1 -- ds50017Minor allele frequency- A:0.01NS EA CSA WA 696
    VAR_0196434
    ----see VAR_0196432 V M mis40--------
    rs138071,2,4
    ----see VAR_0196442 mis40--------

    HapMap Linkage Disequilibrium report for FAU (64888099 - 64889945 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FAU:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1174n71CNV Loss21882294
    nsv526181CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAU
    DNA2.0 Custom Variant and Variant Library Synthesis for FAU

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 134690OMIM information: 194071 604499 607967 609270 609470    
    1 disease for FAU:    
    About MalaCards
    sarcoma


    Find genes that share disorders with FAU           About GenesLikeMe

    3 Novoseek inferred disease relationships for FAU gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sarcoma 67.9 9 1326960 (1), 8395683 (1), 7642109 (1), 7774934 (1) (see all 8)
    osteosarcoma 40.5 1 12660817 (1)
    tumors 0 6 10069470 (2), 12660817 (1), 7512365 (1), 8406491 (1)


    Export disorders for FAU gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAU gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with FAU)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic structure and expression of the human fau gene: encoding the ribosomal protein S30 fused to a ubiquitin-like protein. (PubMed id 1326960)1, 2, 9 Kas K.... Merregaert J. (Biochem. Biophys. Res. Commun. 1992)
    2. fau cDNA encodes a ubiquitin-like-S30 fusion protein and is expressed as an antisense sequence in the Finkel-Biskis-Reilly murine sarcoma virus. (PubMed id 8395683)1, 2, 9 Michiels L....Merregaert J. (Oncogene 1993)
    3. Assignment of the human FAU gene to a subregion of chromosome 11q13. (PubMed id 8406491)1, 3, 9 Kas K....Larsson C. (Genomics 1993)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer. (PubMed id 19671159)1, 9 Pickard M.R.... Williams G.T. (Breast Cancer Res. 2009)
    7. fau and its ubiquitin-like domain (FUBI) transforms human osteogenic sarcoma (HOS) cells to anchorage-independence. (PubMed id 12660817)1, 9 Rossman T.G....Komissarova E.V. (Oncogene 2003)
    8. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6. (PubMed id 23151878)1 Evsyukova I....Garcia-Blanco M.A. (RNA 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2197 HGNC: 3597 AceView: FAUandZNHIT2andSYVN1 Ensembl:ENSG00000149806 euGenes: HUgn2197
    ECgene: FAU Kegg: 2197 H-InvDB: FAU

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAU Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FAU Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fau/
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fau/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAU gene:
    Search GeneIP for patents involving FAU

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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