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Aliases for FAU Gene

Subcategory (RNA class) for FAU Gene

lncRNA

Aliases for FAU Gene

  • FAU, Ubiquitin Like And Ribosomal Protein S30 Fusion 2 3 5
  • Finkel-Biskis-Reilly Murine Sarcoma Virus (FBR-MuSV) Ubiquitously Expressed (Fox Derived) 2 3
  • Monoclonal Nonspecific Suppressor Factor Beta 2 3
  • Small Ribosomal Subunit Protein ES30 3 4
  • Ribosomal Protein S30 2 3
  • Finkel-Biskis-Reilly Murine Sarcoma Virus (FBR-MuSV) Ubiquitously Expressed 2
  • Ubiquitin-Like Protein Fubi And Ribosomal Protein S30 3
  • FBR-MuSV-Associated Ubiquitously Expressed 3
  • FAU-Encoded Ubiquitin-Like Protein 3
  • Ubiquitin-Like-S30 Fusion Protein 3
  • 40S Ribosomal Protein S30 3
  • MNSFbeta 3
  • RPS30 3
  • FAU1 3
  • Fub1 3
  • Fubi 3
  • Asr1 3
  • S30 3

External Ids for FAU Gene

ORGUL Members for FAU Gene

Previous GeneCards Identifiers for FAU Gene

  • GC11M067403
  • GC11M066569
  • GC11M065138
  • GC11M064663
  • GC11M064644
  • GC11M064888
  • GC11M061214

Summaries for FAU Gene

Entrez Gene Summary for FAU Gene

  • This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV). It encodes a fusion protein consisting of the ubiquitin-like protein fubi at the N terminus and ribosomal protein S30 at the C terminus. It has been proposed that the fusion protein is post-translationally processed to generate free fubi and free ribosomal protein S30. Fubi is a member of the ubiquitin family, and ribosomal protein S30 belongs to the S30E family of ribosomal proteins. Whereas the function of fubi is currently unknown, ribosomal protein S30 is a component of the 40S subunit of the cytoplasmic ribosome and displays antimicrobial activity. Pseudogenes derived from this gene are present in the genome. Similar to ribosomal protein S30, ribosomal proteins S27a and L40 are synthesized as fusion proteins with ubiquitin. [provided by RefSeq, Nov 2014]

GeneCards Summary for FAU Gene

FAU (FAU, Ubiquitin Like And Ribosomal Protein S30 Fusion) is a Protein Coding gene, and is affiliated with the lncRNA class. Diseases associated with FAU include Sarcoma and Osteosarcoma, Somatic. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for FAU Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAU Gene

Genomics for FAU Gene

Regulatory Elements for FAU Gene

Enhancers for FAU Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G065414 2.2 FANTOM5 Ensembl ENCODE dbSUPER 18.4 -301.7 -301709 18.8 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZFPL1 NEAT1 LOC105369352 KAT5 EIF1AD FRMD8 MUS81 PCNX3 POLA2 ENSG00000255320
GH11G065470 2.7 VISTA FANTOM5 Ensembl ENCODE dbSUPER 11.1 -367.6 -367611 40.0 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 LOC105369352 ZFPL1 KAT5 ENSG00000254461 EIF1AD NEAT1 FRMD8 EHBP1L1 POLA2 LOC101927789
GH11G065095 1.2 ENCODE 22 +25.8 25781 2.2 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 FAU RNASEH2C ZFPL1 EIF1AD PCNX3 TRMT112 ZNHIT2 MRPL49 FRMD8 PLCB3
GH11G065886 1.9 FANTOM5 ENCODE dbSUPER 10.3 -773.0 -772986 18.4 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 SNX32 CTSW MUS81 EIF1AD ENSG00000254461 KAT5 ZFPL1 RBM4B EFEMP2 ENSG00000258297
GH11G065149 1.3 Ensembl ENCODE 11.8 -29.1 -29098 3.4 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF766 ZNF143 FOS SPDYC MRPL49 PGAM1P8 CAPN1 LOC728975 FAU ZNHIT2 POLA2 SF3B2 RNU2-23P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAU on UCSC Golden Path with GeneCards custom track

Promoters for FAU Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040780 273 1601 MLX CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC SSRP1

Genomic Location for FAU Gene

Chromosome:
11
Start:
65,120,627 bp from pter
End:
65,122,473 bp from pter
Size:
1,847 bases
Orientation:
Minus strand

Genomic View for FAU Gene

Genes around FAU on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAU Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAU Gene

Proteins for FAU Gene

  • Protein details for FAU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35544-UBIM_HUMAN
    Recommended name:
    Ubiquitin-like protein FUBI
    Protein Accession:
    P35544
    Secondary Accessions:
    • Q9H5V4

    Protein attributes for FAU Gene

    Size:
    74 amino acids
    Molecular mass:
    7760 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This protein is synthesized with ribosomal S30 as its C-terminal extension.

    Three dimensional structures from OCA and Proteopedia for FAU Gene

  • Protein details for FAU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62861-RS30_HUMAN
    Recommended name:
    40S ribosomal protein S30
    Protein Accession:
    P62861
    Secondary Accessions:
    • Q05472
    • Q95261
    • Q9H5V4

    Protein attributes for FAU Gene

    Size:
    59 amino acids
    Molecular mass:
    6648 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This ribosomal protein is synthesized as a C-terminal extension protein (CEP) of a ubiquitin-like protein.
    SequenceCaution:
    • Sequence=AAH33877.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ87877.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15515.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA46714.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA46716.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAG46772.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FAU Gene

neXtProt entry for FAU Gene

Post-translational modifications for FAU Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAU Gene

Domains & Families for FAU Gene

Gene Families for FAU Gene

Protein Domains for FAU Gene

Suggested Antigen Peptide Sequences for FAU Gene

Graphical View of Domain Structure for InterPro Entry

P62861

UniProtKB/Swiss-Prot:

RS30_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eS30 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eS30 family.
  • Belongs to the ubiquitin family.
genes like me logo Genes that share domains with FAU: view

Function for FAU Gene

Molecular function for FAU Gene

GENATLAS Biochemistry:
Finkel-Biskis-Reilly (FBR)-murine sarcoma virus associated,ubiquitously expressed,viral FOX homolog

Gene Ontology (GO) - Molecular Function for FAU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,TAS 22681889
GO:0003735 structural constituent of ribosome IEA --
genes like me logo Genes that share ontologies with FAU: view
genes like me logo Genes that share phenotypes with FAU: view

Animal Model Products

CRISPR Products

miRNA for FAU Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAU

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAU Gene

Localization for FAU Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAU gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FAU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005615 extracellular space IDA --
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FAU: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAU Gene

Pathways & Interactions for FAU Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.56
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with FAU: view

Gene Ontology (GO) - Biological Process for FAU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002227 innate immune response in mucosa IDA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA --
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with FAU: view

No data available for SIGNOR curated interactions for FAU Gene

Drugs & Compounds for FAU Gene

(1) Additional Compounds for FAU Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FAU: view

Transcripts for FAU Gene

Unigene Clusters for FAU Gene

Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAU

Alternative Splicing Database (ASD) splice patterns (SP) for FAU Gene

No ASD Table

Relevant External Links for FAU Gene

GeneLoc Exon Structure for
FAU
ECgene alternative splicing isoforms for
FAU

Expression for FAU Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAU Gene

Protein differential expression in normal tissues from HIPED for FAU Gene

This gene is overexpressed in Bone (8.1), Bone marrow stromal cell (6.1), and Liver (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAU Gene



Protein tissue co-expression partners for FAU Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAU Gene:

FAU

SOURCE GeneReport for Unigene cluster for FAU Gene:

Hs.387208

Evidence on tissue expression from TISSUES for FAU Gene

  • Intestine(4.6)
  • Nervous system(4.6)
  • Lung(4.4)
  • Liver(3.6)
  • Muscle(3.5)
  • Heart(3.4)
  • Blood(3.1)
  • Eye(3.1)
  • Kidney(3)
  • Spleen(2.8)
  • Bone marrow(2.6)
  • Lymph node(2.6)
  • Skin(2.6)
  • Adrenal gland(2.4)
  • Pancreas(2.4)
  • Gall bladder(2.3)
  • Stomach(2.3)
  • Thyroid gland(2.3)
genes like me logo Genes that share expression patterns with FAU: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAU Gene

Orthologs for FAU Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FAU Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAU 34 35
  • 99.75 (n)
mouse
(Mus musculus)
Mammalia Gm9843 35
  • 98 (a)
OneToMany
Fau 34 16 35
  • 91.48 (n)
dog
(Canis familiaris)
Mammalia FAU 34
  • 92.23 (n)
-- 35
  • 68 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Fau 34
  • 91.23 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 91 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FAU 34 35
  • 90.98 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 90 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 83 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC89853 34
  • 75.69 (n)
Str.17035 34
zebrafish
(Danio rerio)
Actinopterygii faua 34 35
  • 72.93 (n)
faub 35
  • 72 (a)
ManyToMany
zgc73171 34
fruit fly
(Drosophila melanogaster)
Insecta RpS30 35 34
  • 63.28 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000654 34
  • 60.68 (n)
worm
(Caenorhabditis elegans)
Secernentea rps-30 35 34
  • 58.07 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS30A 37
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6329 34
Species where no ortholog for FAU was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAU Gene

ENSEMBL:
Gene Tree for FAU (if available)
TreeFam:
Gene Tree for FAU (if available)

Paralogs for FAU Gene

(8) SIMAP similar genes for FAU Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FAU: view

No data available for Paralogs for FAU Gene

Variants for FAU Gene

Sequence variations from dbSNP and Humsavar for FAU Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000188824 -- 65,122,657(+) CAACG(C/T)TTCAG intron-variant, upstream-variant-2KB
rs1001216092 -- 65,122,399(+) TGTCC(A/C)GCGGG intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1001628612 -- 65,123,613(+) CCTGT(A/C)GTCCC intron-variant, upstream-variant-2KB
rs1002071969 -- 65,123,203(+) CTTGA(C/T)TGACT intron-variant, upstream-variant-2KB
rs1003542760 -- 65,123,903(+) TTTGT(A/T)TGAGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAU Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV gain 19592680

Variation tolerance for FAU Gene

Residual Variation Intolerance Score: 53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAU Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAU

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAU Gene

Disorders for FAU Gene

MalaCards: The human disease database

(2) MalaCards diseases for FAU Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
sarcoma
  • connective and soft tissue neoplasm
osteosarcoma, somatic
  • osteosarcoma
- elite association - COSMIC cancer census association via MalaCards
Search FAU in MalaCards View complete list of genes associated with diseases

Relevant External Links for FAU

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAU
genes like me logo Genes that share disorders with FAU: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAU Gene

Publications for FAU Gene

  1. Assignment of the human FAU gene to a subregion of chromosome 11q13. (PMID: 8406491) Kas K. … Larsson C. (Genomics 1993) 2 3 22 64
  2. fau cDNA encodes a ubiquitin-like-S30 fusion protein and is expressed as an antisense sequence in the Finkel-Biskis-Reilly murine sarcoma virus. (PMID: 8395683) Michiels L. … Merregaert J. (Oncogene 1993) 3 4 22 64
  3. Genomic structure and expression of the human fau gene: encoding the ribosomal protein S30 fused to a ubiquitin-like protein. (PMID: 1326960) Kas K. … Merregaert J. (Biochem. Biophys. Res. Commun. 1992) 3 4 22 64
  4. Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer. (PMID: 19671159) Pickard M.R. … Williams G.T. (Breast Cancer Res. 2009) 3 22 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for FAU Gene

Sources for FAU Gene