Aliases for FAU Gene
Subcategory (RNA class) for FAU Gene
Aliases for FAU Gene
- FAU, Ubiquitin Like And Ribosomal Protein S30 Fusion 2 3 5
- Finkel-Biskis-Reilly Murine Sarcoma Virus (FBR-MuSV) Ubiquitously Expressed (Fox Derived) 2 3
- Monoclonal Nonspecific Suppressor Factor Beta 2 3
- Small Ribosomal Subunit Protein ES30 3 4
- Ribosomal Protein S30 2 3
- Finkel-Biskis-Reilly Murine Sarcoma Virus (FBR-MuSV) Ubiquitously Expressed 2
- Ubiquitin-Like Protein Fubi And Ribosomal Protein S30 3
- FBR-MuSV-Associated Ubiquitously Expressed 3
- FAU-Encoded Ubiquitin-Like Protein 3
- Ubiquitin-Like-S30 Fusion Protein 3
External Ids for FAU Gene
ORGUL Members for FAU Gene
Previous GeneCards Identifiers for FAU Gene
- GC11M067403
- GC11M066569
- GC11M065138
- GC11M064663
- GC11M064644
- GC11M064888
- GC11M061214
Summaries for FAU Gene
-
This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV). It encodes a fusion protein consisting of the ubiquitin-like protein fubi at the N terminus and ribosomal protein S30 at the C terminus. It has been proposed that the fusion protein is post-translationally processed to generate free fubi and free ribosomal protein S30. Fubi is a member of the ubiquitin family, and ribosomal protein S30 belongs to the S30E family of ribosomal proteins. Whereas the function of fubi is currently unknown, ribosomal protein S30 is a component of the 40S subunit of the cytoplasmic ribosome and displays antimicrobial activity. Pseudogenes derived from this gene are present in the genome. Similar to ribosomal protein S30, ribosomal proteins S27a and L40 are synthesized as fusion proteins with ubiquitin. [provided by RefSeq, Nov 2014]
GeneCards Summary for FAU Gene
FAU (FAU, Ubiquitin Like And Ribosomal Protein S30 Fusion) is a Protein Coding gene, and is affiliated with the lncRNA class. Diseases associated with FAU include Sarcoma and Osteosarcoma, Somatic. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAU Gene
Genomics for FAU Gene
Regulatory Elements for FAU Gene
Regulatory Element Products
Genomic Location for FAU Gene
- Chromosome:
- 11
- Start:
- 65,120,627 bp from pter
- End:
- 65,122,473 bp from pter
- Size:
- 1,847 bases
- Orientation:
- Minus strand
Genomic View for FAU Gene
- Cytogenetic band:
-
- 11q13.1 by Ensembl
- 11q13.1 by Entrez Gene
- 11q13.1 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FAU Gene
Proteins for FAU Gene
-
Protein details for FAU Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35544-UBIM_HUMAN
- Recommended name:
- Ubiquitin-like protein FUBI
- Protein Accession:
- P35544
- Q9H5V4
Protein attributes for FAU Gene
- Size:
- 74 amino acids
- Molecular mass:
- 7760 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- This protein is synthesized with ribosomal S30 as its C-terminal extension.
-
Protein details for FAU Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62861-RS30_HUMAN
- Recommended name:
- 40S ribosomal protein S30
- Protein Accession:
- P62861
- Q05472
- Q95261
- Q9H5V4
Protein attributes for FAU Gene
- Size:
- 59 amino acids
- Molecular mass:
- 6648 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- This ribosomal protein is synthesized as a C-terminal extension protein (CEP) of a ubiquitin-like protein.
- SequenceCaution:
-
- Sequence=AAH33877.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ87877.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15515.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA46714.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA46716.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAG46772.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for FAU Gene
Post-translational modifications for FAU Gene
Other Protein References for FAU Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for FAU (FUBI/MNSF beta)
-
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- antibodies-online Antibodies for FAU: See all 90
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Protein Products
- R&D Systems Proteins and Enzymes for FAU (FUBI/MNSF beta)
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-
OriGene Purified Proteins for FAU
- Search Origene for MassSpec and Protein Over-expression Lysates for FAU
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- antibodies-online Proteins for FAU: See all 23
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Assay Products
- antibodies-online Kits for FAU: See all 21
No data available for DME Specific Peptides for FAU Gene
Domains & Families for FAU Gene
Gene Families for FAU Gene
Protein Domains for FAU Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FAU Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P62861- Family:
-
- Belongs to the eukaryotic ribosomal protein eS30 family.
- Belongs to the ubiquitin family.
Function for FAU Gene
Molecular function for FAU Gene
- GENATLAS Biochemistry:
- Finkel-Biskis-Reilly (FBR)-murine sarcoma virus associated,ubiquitously expressed,viral FOX homolog
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IDA,TAS | 22681889 |
| GO:0003735 | structural constituent of ribosome | IEA | -- |
Phenotypes for FAU Gene
- GenomeRNAi human phenotypes for FAU:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased NF-kappaB reporter expression
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Nucleoplasmic pre-40S maturation defects
- Decreased viability
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased cell number in S
- Decreased influenza A/WSN/33 replication
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased cell number
- Decreased viability of wild-type and TP53 knockout cells
- Decreased DCP1a protein expression and assembly in processing bodies after arsenite stimulation
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased lymphocytic choriomeningitis virus (LCMV) infection
- Decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Decreased influenza A H1N1 (A/WSN/33) virus numbers
- Decreased human parainfluenza virus type 3 (HPIV3) infection
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FAU gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FAU gene
- Search ViGene Biosciences for FAU
CRISPR Products
-
OriGene CRISPR knockouts for FAU
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAU
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miRNA for FAU Gene
- miRTarBase miRNAs that target FAU
miRNA Products
- Search ViGene Biosciences for FAU
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FAU
- Browse OriGene Inhibitory RNA Products For FAU
-
ViGene Biosciences ready-to-package AAV shRNAs for FAU gene
Clone Products
- Sino Biological Human cDNA Clone for FAU
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Cell Line Products
-
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-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAU Gene
Localization for FAU Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0005615 | extracellular space | IDA | -- |
| GO:0005622 | intracellular | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAU Gene
Pathways & Interactions for FAU Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Viral mRNA Translation |
.77
.56
|
|
| 2 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||
| 3 | Influenza Viral RNA Transcription and Replication | ||
| 4 | rRNA processing in the nucleus and cytosol |
.89
|
|
| 5 | HIV Life Cycle |
.45
|
|
Pathways by source for FAU Gene
2 BioSystems pathways for FAU Gene
1 KEGG pathway for FAU Gene
1 GeneGo (Thomson Reuters) pathway for FAU Gene
Interacting Proteins for FAU Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002227 | innate immune response in mucosa | IDA | -- |
| GO:0006364 | rRNA processing | TAS | -- |
| GO:0006412 | translation | IEA | -- |
| GO:0006413 | translational initiation | TAS | -- |
| GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | TAS | -- |
No data available for SIGNOR curated interactions for FAU Gene
Transcripts for FAU Gene
mRNA/cDNA for FAU Gene
- (1565) Selected AceView cDNA sequences:
- (4) Additional mRNA sequences :
- (1) REFSEQ mRNAs :
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FAU Gene
CRISPR Products
-
OriGene CRISPR knockouts for FAU
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAU
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miRNA Products
- Search ViGene Biosciences for FAU
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FAU
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-
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Clone Products
- Sino Biological Human cDNA Clone for FAU
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Flow Cytometry Products
Expression for FAU Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAU Gene
NURSA nuclear receptor signaling pathways regulating expression of FAU Gene:
FAUSOURCE GeneReport for Unigene cluster for FAU Gene:
Hs.387208Evidence on tissue expression from TISSUES for FAU Gene
- Intestine(4.6)
- Nervous system(4.6)
- Lung(4.4)
- Liver(3.6)
- Muscle(3.5)
- Heart(3.4)
- Blood(3.1)
- Eye(3.1)
- Kidney(3)
- Spleen(2.8)
- Bone marrow(2.6)
- Lymph node(2.6)
- Skin(2.6)
- Adrenal gland(2.4)
- Pancreas(2.4)
- Gall bladder(2.3)
- Stomach(2.3)
- Thyroid gland(2.3)
Primer Products
-
OriGene qPCR primer pairs for FAU
-
OriGene qPCR primer pairs and template standards for FAU
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAU Gene
Orthologs for FAU Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FAU 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Gm9843 35 |
|
OneToMany | |
| Fau 34 16 35 |
|
||||
| dog (Canis familiaris) |
Mammalia | FAU 34 |
|
||
| -- 35 |
|
ManyToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Fau 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | FAU 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | MGC89853 34 |
|
||
| Str.17035 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | faua 34 35 |
|
||
| faub 35 |
|
ManyToMany | |||
| zgc73171 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | RpS30 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000654 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | rps-30 34 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPS30A 37 |
|
|
|
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.6329 34 |
|
- Species where no ortholog for FAU was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FAU Gene
(8) SIMAP similar genes for FAU Gene using alignment to 6 proteins:
Pseudogenes.org Pseudogenes for FAU Gene
No data available for Paralogs for FAU Gene
Variants for FAU Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000188824 | -- | 65,122,657(+) | CAACG(C/T)TTCAG | intron-variant, upstream-variant-2KB | |
| rs1001216092 | -- | 65,122,399(+) | TGTCC(A/C)GCGGG | intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense | |
| rs1001628612 | -- | 65,123,613(+) | CCTGT(A/C)GTCCC | intron-variant, upstream-variant-2KB | |
| rs1002071969 | -- | 65,123,203(+) | CTTGA(C/T)TGACT | intron-variant, upstream-variant-2KB | |
| rs1003542760 | -- | 65,123,903(+) | TTTGT(A/T)TGAGA | intron-variant, upstream-variant-2KB |
Relevant External Links for FAU Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FAU
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAU Gene
Disorders for FAU Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| sarcoma |
|
|
| osteosarcoma, somatic |
|
Relevant External Links for FAU
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FAU
No data available for UniProtKB/Swiss-Prot and Genatlas for FAU Gene
Publications for FAU Gene
- fau cDNA encodes a ubiquitin-like-S30 fusion protein and is expressed as an antisense sequence in the Finkel-Biskis-Reilly murine sarcoma virus. (PMID: 8395683) Michiels L. … Merregaert J. (Oncogene 1993) 3 4 22 64
- Assignment of the human FAU gene to a subregion of chromosome 11q13. (PMID: 8406491) Kas K. … Larsson C. (Genomics 1993) 2 3 22 64
- Genomic structure and expression of the human fau gene: encoding the ribosomal protein S30 fused to a ubiquitin-like protein. (PMID: 1326960) Kas K. … Merregaert J. (Biochem. Biophys. Res. Commun. 1992) 3 4 22 64
- Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer. (PMID: 19671159) Pickard M.R. … Williams G.T. (Breast Cancer Res. 2009) 3 22 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
Products for FAU Gene
- R&D Systems Antibodies for FAU (FUBI/MNSF beta)
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- Custom Antibody ServicesOriGene Antibodies for FAU
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- antibodies-online Antibodies for FAU: See all 90
- antibodies-online Kits for FAU: See all 21
- antibodies-online Proteins for FAU: See all 23
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- Cyagen custom Knockout/knockin (KOKI) mouse models for FAU
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- Mammalian expression: PiggyBac
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FAU Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
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- (122) diseasecard
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- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
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- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




