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FATE1 Gene

protein-coding   GIFtS: 48
GCID: GC0XP150884

Fetal And Adult Testis Expressed 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fetal And Adult Testis Expressed 11 2     FATE2 3
Cancer/Testis Antigen 431 2 3     BJ-HCC-2 Antigen2
Tumor Antigen BJ-HCC-22 3     Fetal And Adult Testis Expressed Transcript Protein2
CT432 3     Fetal And Adult Testis-Expressed Transcript Protein2

External Ids:    HGNC: 246831   Entrez Gene: 898852   Ensembl: ENSG000001473787   OMIM: 3004505   UniProtKB: Q969F03   

Export aliases for FATE1 gene to outside databases

Previous GC identifers: GC0XP150555 GC0XP139741


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FATE1 Gene:
This gene encodes a cancer-testis antigen that is highly expressed in hepatocellular carcinomas and other tumors
and weakly expressed in normal tissues except testis. The protein is strongly expressed in spermatogonia, primary
spermatocytes, and Sertoli cells in seminiferous tubules. This protein may have a role in the control of early
testicular differentiation and cell proliferation. (provided by RefSeq, Jan 2010)

GeneCards Summary for FATE1 Gene:
FATE1 (fetal and adult testis expressed 1) is a protein-coding gene.

Gene Wiki entry for FATE1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011681.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the FATE1 gene promoter:
         CREB   RFX1   AML1a   deltaCREB   HFH-1   Sox9   GATA-1   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFATE1 promoter sequence
   Search Chromatin IP Primers for FATE1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FATE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

FATE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FATE1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP150884:  view genomic region     (about GC identifiers)

Start:
150,884,507 bp from pter      End:
150,891,666 bp from pter
Size:
7,160 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB/Swiss-Prot: FATE1_HUMAN, Q969F0 (See protein sequence)
Recommended Name: Fetal and adult testis-expressed transcript protein  
Size: 183 amino acids; 20712 Da

Explore the universe of human proteins at neXtProt for FATE1: NX_Q969F0

Explore proteomics data for FATE1 at MOPED


See FATE1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_149076.1  
ENSEMBL proteins: 
 ENSP00000359375   ENSP00000400493  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR008518 FATE/Miff/Tango-11

Graphical View of Domain Structure for InterPro Entry Q969F0

ProtoNet protein and cluster: Q969F0


Find genes that share domains with FATE1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     2 GenomeRNAi human phenotypes for FATE1:
 Decreased melanin production  Decreased viability with pacli 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for FATE1

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
FATE1_HUMAN, Q969F0: Membrane; Single-pass membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
endoplasmic reticulum4
plasma membrane2
cytosol1
extracellular1
nucleus1
peroxisome1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005783endoplasmic reticulum IDA--
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with FATE1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FATE1
Interactions:

    GeneGlobe Interaction Network for FATE1

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

Selected Interacting proteins for FATE1 (Q969F02, 3 ENSP000003593754) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
InteractantInteraction Details
GeneCardExternal ID(s)
RNF183Q96D592, 3, ENSP000004207404MINT-66409 I2D: score=4 STRING: ENSP00000420740
TBPP202262, 3, ENSP000002303544MINT-2877815 I2D: score=3 STRING: ENSP00000230354
EMDP504023, ENSP000003588574I2D: score=4 STRING: ENSP00000358857
TRAF2Q129333, ENSP000002476684I2D: score=5 STRING: ENSP00000247668
USHBP1Q8N6Y03, ENSP000002525974I2D: score=4 STRING: ENSP00000252597
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for FATE1



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for FATE1 gene: 
NM_033085.2  

Unigene Cluster for FATE1:

Fetal and adult testis expressed 1
Hs.301960  [show with all ESTs]
Unigene Representative Sequence: BM553063
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000370350(uc004fex.3) ENST00000417321
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Additional mRNA sequence: 

AF249872.1 AY101182.1 BC022064.2 

1 DOTS entry:

DT.412993 

Selected AceView cDNA sequences (see all 44):

BX093184 BI828914 AF249872 AA382397 AA383295 NM_033085 BM908055 AX810709 
AA382398 AA399608 AA868750 CR624422 AA411925 AA460295 AA453483 BX335212 
BM553063 BI826717 AA873771 BG104650 AA383296 BI520333 BI830495 BI826622 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for FATE1    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:                                          
SP2:                    -                     


ECgene alternative splicing isoforms for FATE1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FATE1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCGGCATCTG
FATE1 Expression
About this image

FATE1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

FATE1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.301960

UniProtKB/Swiss-Prot: FATE1_HUMAN, Q969F0
Tissue specificity: Testis-specific in fetus (aged from 6 to 11 weeks). In adult, expressed predominantly in
testis, with some expression in lung, heart, kidney, adrenal gland and whole brain

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for FATE1 gene from Selected species (see all 4)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fate15 fetal and adult testis expressed 1   --   X (37.15 cM) 71972986 


ENSEMBL Gene Tree for FATE1 (if available)
TreeFam Gene Tree for FATE1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FATE1 (see all 198)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1509939911,2
--150748948(+) CCCACA/CAGGGC 1 -- us2k10--------
rs1856005111,2
--150749013(+) CCAGTG/TCCCAC 1 -- us2k10--------
rs1139352791,2
C--150749188(+) CAGCTA/GAATTT 1 -- us2k10--------
rs1914332001,2
--150749194(+) AATTTC/TAATGT 1 -- us2k10--------
rs1837480541,2
--150749467(+) GCCCCA/CAGGAA 1 -- us2k10--------
rs1869921031,2
--150749628(+) TTCCTC/TCCTTC 1 -- us2k10--------
rs1923295831,2
--150749632(+) TTCCTC/TCCTTC 1 -- us2k10--------
rs1840607701,2
--150749640(+) TTCCTC/TCCTTC 1 -- us2k10--------
rs1867796621,2
--150749727(+) AGAGGC/TTATTT 1 -- us2k10--------
rs789391931,2
C,F--150749790(+) TATTCT/CCCCAG 1 -- us2k11Minor allele frequency- C:0.00WA 2

HapMap Linkage Disequilibrium report for FATE1 (150884507 - 150891666 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for FATE1: --
Locus Specific Mutation Databases (LSDB): FATE1

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SeqTarget long-range PCR primers for resequencing FATE1
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 300450    OMIM disorders: --

1 disease from the University of Copenhagen DISEASES database for FATE1:
Adrenal cortex cancer

Find genes that share disorders with FATE1           About GenesLikeMe


Export disorders for FATE1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FATE1 gene, integrated from 10 sources (see all 16):
(articles sorted by number of sources associating them with FATE1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human FATE is a novel X-linked gene expressed in fetal and adult testis. (PubMed id 11694338)1, 2, 3 Olesen C.... Tommerup N. (Mol. Cell. Endocrinol. 2001)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Mutational analysis of the human FATE gene in 144 infertile men. (PubMed id 12811541)1, 2 Olesen C....Tommerup N. (Hum. Genet. 2003)
  5. Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)1 Zhou H....Espeseth A.S. (amp 2008)
  6. Increased steroidogenic factor-1 dosage triggers adrenocortical cell proliferation and cancer. (PubMed id 17761949)1 Doghman M....Lalli E. (Mol. Endocrinol. 2007)
  7. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (Cell 2006)
  8. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (Nucleic Acids Res. 2006)
  9. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
  10. Immunohistochemical analysis of the expression of FATE/BJ-HCC-2 antigen in normal and malignant tissues. (PubMed id 15580283)1 Yang X.A....Chen W.F. ( a journal of technical methods and pathology 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 89885 HGNC: 24683 AceView: FATE1 Ensembl:ENSG00000147378 euGenes: HUgn89885
ECgene: FATE1 H-InvDB: FATE1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for FATE1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for FATE1 gene:
Search GeneIP for patents involving FATE1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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