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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FATE1 Gene

protein-coding   GIFtS: 48
GCID: GC0XP150884

Fetal And Adult Testis Expressed 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fetal And Adult Testis Expressed 11 2     FATE2 3
Cancer/Testis Antigen 431 2 3     BJ-HCC-2 Antigen2
Tumor Antigen BJ-HCC-22 3     Fetal And Adult Testis Expressed Transcript Protein2
CT432 3     Fetal And Adult Testis-Expressed Transcript Protein2

External Ids:    HGNC: 246831   Entrez Gene: 898852   Ensembl: ENSG000001473787   OMIM: 3004505   UniProtKB: Q969F03   

Export aliases for FATE1 gene to outside databases

Previous GC identifers: GC0XP150555 GC0XP139741


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FATE1 Gene:
This gene encodes a cancer-testis antigen that is highly expressed in hepatocellular carcinomas and other tumors
and weakly expressed in normal tissues except testis. The protein is strongly expressed in spermatogonia, primary
spermatocytes, and Sertoli cells in seminiferous tubules. This protein may have a role in the control of early
testicular differentiation and cell proliferation. (provided by RefSeq, Jan 2010)

GeneCards Summary for FATE1 Gene: 
FATE1 (fetal and adult testis expressed 1) is a protein-coding gene. Diseases associated with FATE1 include male infertility, and hepatocellular carcinoma.

Gene Wiki entry for FATE1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_167198.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FATE1 gene promoter:
         CREB   RFX1   AML1a   deltaCREB   HFH-1   Sox9   GATA-1   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFATE1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FATE1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FATE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

FATE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FATE1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP150884:  view genomic region     (about GC identifiers)

Start:
150,884,507 bp from pter      End:
150,891,666 bp from pter
Size:
7,160 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FATE1_HUMAN, Q969F0 (See protein sequence)
Recommended Name: Fetal and adult testis-expressed transcript protein  
Size: 183 amino acids; 20712 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)

Explore the universe of human proteins at neXtProt for FATE1: NX_Q969F0

Explore proteomics data for FATE1 at MOPED 

FATE1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

FATE1 Protein Expression

REFSEQ proteins: NP_149076.1  
ENSEMBL proteins: 
 ENSP00000359375   ENSP00000400493  

Human Recombinant Protein Products for FATE1: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005783endoplasmic reticulum IDA--
GO:0016021integral to membrane IEA--

FATE1 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR008518 FATE/Miff/Tango-11

Graphical View of Domain Structure for InterPro Entry Q969F0

ProtoNet protein and cluster: Q969F0


FATE1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
     2 GenomeRNAi human phenotypes for FATE1:
 Decreased melanin production  Decreased viability with pacli 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for FATE1 
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section




Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FATE1

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/16 Interacting proteins for FATE1 (Q969F02, 3 ENSP000003593754) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
InteractantInteraction Details
GeneCardExternal ID(s)
RNF183Q96D592, 3, ENSP000004207404MINT-66409 I2D: score=4 STRING: ENSP00000420740
TBPP202262, 3, ENSP000002303544MINT-2877815 I2D: score=3 STRING: ENSP00000230354
EMDP504023, ENSP000003588574I2D: score=4 STRING: ENSP00000358857
TRAF2Q129333, ENSP000002476684I2D: score=5 STRING: ENSP00000247668
USHBP1Q8N6Y03, ENSP000002525974I2D: score=4 STRING: ENSP00000252597
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FATE1

Search CenterWatch for drugs/clinical trials and news about FATE1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FATE1 gene: 
NM_033085.2  

Unigene Cluster for FATE1:

Fetal and adult testis expressed 1
Hs.301960  [show with all ESTs]
Unigene Representative Sequence: BM553063
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000370350(uc004fex.3) ENST00000417321
miRNA
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Inhib. RNA
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FATE1

Additional mRNA sequence: 

AF249872.1 AY101182.1 BC022064.2 

1 DOTS entry:

DT.412993 

24/44 AceView cDNA sequences (see all 44):

BI828914 NM_033085 AF249872 BX093184 AA382397 BM908055 CR624422 AA382398 
AX810709 AA868750 AA383295 AA399608 BX335212 AA411925 BG104650 AA460295 
BI826717 BG723556 AA453483 BI826622 AA873771 BC022064 AA461583 AA782988 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for FATE1    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:                                          
SP2:                    -                     


ECgene alternative splicing isoforms for FATE1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FATE1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCGGCATCTG
FATE1 Expression
About this image


See FATE1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FATE1

SOURCE GeneReport for Unigene cluster: Hs.301960

UniProtKB/Swiss-Prot: FATE1_HUMAN, Q969F0
Tissue specificity: Testis-specific in fetus (aged from 6 to 11 weeks). In adult, expressed predominantly in
testis, with some expression in lung, heart, kidney, adrenal gland and whole brain

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FATE1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FATE1 gene from 2/5 species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fate15 fetal and adult testis expressed 1   --   X (37.15 cM) 71972986 
chicken
(Gallus gallus)
Aves FATE16
fetal and adult testis expressed 1
14(a)
1 ↔ 1
4(10899661-10906667)


ENSEMBL Gene Tree for FATE1 (if available)
TreeFam Gene Tree for FATE1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/198 SNPs in FATE1 are shown (see all 198)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0169184
----see VAR_0169182 I T mis40--------
VAR_0169194
----see VAR_0169192 S R mis40--------
rs1509939911,2
--150748948(+) CCCACA/CAGGGC 1 -- us2k10--------
rs1856005111,2
--150749013(+) CCAGTG/TCCCAC 1 -- us2k10--------
rs1139352791,2
C--150749188(+) CAGCTA/GAATTT 1 -- us2k10--------
rs1914332001,2
--150749194(+) AATTTC/TAATGT 1 -- us2k10--------
rs1837480541,2
--150749467(+) GCCCCA/CAGGAA 1 -- us2k10--------
rs1869921031,2
--150749628(+) TTCCTC/TCCTTC 1 -- us2k10--------
rs1923295831,2
--150749632(+) TTCCTC/TCCTTC 1 -- us2k10--------
rs1840607701,2
--150749640(+) TTCCTC/TCCTTC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for FATE1 (150884507 - 150891666 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for FATE1: --

Locus Specific Mutation Databases (LSDB): FATE1
SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 300450    OMIM disorders: --

3 diseases for FATE1:    About MalaCards
male infertility    hepatocellular carcinoma    infertility

1 disease from the University of Copenhagen DISEASES database for FATE1:
Adrenal cortex cancer

FATE1 for disorders           About GeneDecksing


Export disorders for FATE1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for FATE1 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with FATE1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human FATE is a novel X-linked gene expressed in fetal and adult testis. (PubMed id 11694338)1, 2, 3 Olesen C.... Tommerup N. (2001)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  4. Mutational analysis of the human FATE gene in 144 infertile men. (PubMed id 12811541)1, 2 Olesen C....Tommerup N. (2003)
  5. Increased steroidogenic factor-1 dosage triggers adrenocortical cell proliferation and cancer. (PubMed id 17761949)1 Doghman M....Lalli E. (2007)
  6. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
  7. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
  8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
  9. Immunohistochemical analysis of the expression of FAT E/BJ-HCC-2 antigen in normal and malignant tissues. (PubMed id 15580283)1 Yang X.A....Chen W.F. (2005)
  10. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 89885 HGNC: 24683 AceView: FATE1 Ensembl:ENSG00000147378 euGenes: HUgn89885
ECgene: FATE1 H-InvDB: FATE1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for FATE1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for FATE1 gene:
Search GeneIP for patents involving FATE1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Regulatory tfbs in FATE1 promoter
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 Proteins for FATE1
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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