FATE1 Gene
protein-coding GIFtS: 47
GCID: GC0XP150884
|
|
fetal and adult testis expressed 1
| |
Aliases
for FATE1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fetal And Adult Testis Expressed 11 2 | | Tumor Antigen BJ-HCC-22 3 | | CT431 2 3 | | BJ-HCC-2 Antigen2 | | FATE1 2 3 | | Fetal And Adult Testis Expressed Transcript Protein2 | | Cancer/Testis Antigen 432 3 | | Fetal And Adult Testis-Expressed Transcript Protein2 |
Export aliases for FATE1 gene to outside databasesPrevious GC identifers: GC0XP150555 GC0XP139741 |
Summaries
for FATE1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FATE1:
This gene encodes a cancer-testis antigen that is highly expressed in hepatocellular carcinomas and other tumors andweakly expressed in normal tissues except testis. The protein is strongly expressed in spermatogonia, primaryspermatocytes, and Sertoli cells in seminiferous tubules. This protein may have a role in the control of earlytesticular differentiation and cell proliferation. (provided by RefSeq, Jan 2010)
Gene Wiki entry for FATE1
|
Genomic Views
for FATE1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167198.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FATE1 gene promoter:
CREB RFX1 AML1a deltaCREB HFH-1 Sox9 GATA-1 Arnt
Other transcription factors
Search SABiosciences Chromatin IP Primers for FATE1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FATE1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28FATE1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP150884: view genomic region
(about GC identifiers)
Start:
|
150,884,507 bp from pter |
End:
|
150,891,666 bp from pter |
Size:
|
7,160 bases |
Orientation:
|
plus strand |
|
Proteins
for FATE1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FATE1_HUMAN, Q969F0 (See
protein sequence)Recommended Name: Fetal and adult testis-expressed transcript protein Size: 183 amino acids; 20712 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)Explore the universe of human proteins at neXtProt for FATE1: NX_Q969F0
FATE1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_149076.1
ENSEMBL proteins: ENSP00000359375 ENSP00000400493
Human Recombinant Protein Products for FATE1:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005783 | endoplasmic reticulum |
IDA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
FATE1 for ontologies About GeneDecksing
FATE1 Antibody Products:
Assay Products for FATE1: |
Protein
Domains /
Families
for FATE1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FATE1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q969F0ProtoNet protein and cluster: Q969F0 |
Function
for FATE1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
2 GenomeRNAi human phenotypes for FATE1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FATE1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FATE1
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FATE1 |
|
Pathways & Interactions
for FATE1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FATE1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/16 Interacting proteins for FATE1 (Q969F02, 3 ENSP000003593754) via UniProtKB, MINT, STRING, and/or I2D (see all 16)About this table
|
Drugs & Compounds
for FATE1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FATE1
Search CenterWatch for drugs/clinical trials and news about FATE1
|
Transcripts
for FATE1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FATE1 gene: NM_033085.2 Unigene Cluster for FATE1: Fetal and adult testis expressed 1 Hs.301960 [show with all ESTs]Unigene Representative Sequence: BM5530632 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000370350(uc004fex.3) ENST00000417321
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FATE1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FATE1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FATE1 (NM_033085) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FATE1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FATE1 |
Additional cDNA sequence: AF249872.1 AY101182.1 BC022064.2 1 DOTS entry: DT.412993 24/44 AceView cDNA sequences (see all 44): AF249872 AA383295 BX093184 AA868750 AX810709 AA399608 BM908055 NM_033085 AA382398 BI828914 AA382397 CR624422 BI830495 BI825958 AA460295 BG723556 BI826717 AA782988 BC022064 BP369249 AA453482 BI826622 BM553063 AA461583
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for FATE1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b |
|---|
|
| SP1: | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for FATE1
|
Expression
for FATE1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FATE1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCGGCATCTG
About this image
See FATE1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FATE1
SOURCE GeneReport for Unigene cluster: Hs.301960
UniProtKB/Swiss-Prot: FATE1_HUMAN, Q969F0Tissue specificity: Testis-specific in fetus (aged from 6 to 11 weeks). In adult, expressed predominantly in testis,with some expression in lung, heart, kidney, adrenal gland and whole brain
SABiosciences Custom PCR Arrays for FATE1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FATE1
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FATE1 |
Orthologs
for FATE1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for FATE1 gene from 1/4 species (see all 4) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Fate15 |
fetal and adult testis expressed 1 |
-- |
|
X (37.15 cM) 71972986 |
ENSEMBL Gene Tree for FATE1 (if available)
TreeFam Gene Tree for FATE1 (if available) |
Paralogs
for FATE1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for FATE1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FATE1 (150884507 - 150891666 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FATE1: --
Locus Specific Mutation Databases (LSDB): FATE1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FATE1 |
|
Disorders
/ Diseases
for FATE1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FATE1 for disorders About GeneDecksing
OMIM gene information: 300450
OMIM disorders: --
7  diseases for FATE1: About MalaCardshepatocellular carcinoma carcinoma tumors of adrenal cortex adrenocortical hyperplasia
male infertility infertility ataxia
1 disease from the University of Copenhagen DISEASES database for FATE1:Adrenal cortex cancer Export disorders for FATE1 gene to outside databases
|
Publications
for FATE1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FATE1 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with FATE1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human FATE is a novel X-linked gene expressed in fetal and adult testis. (PubMed id 11694338)1, 2, 3 Olesen C.... Tommerup N. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Mutational analysis of the human FATE gene in 144 infertile men. (PubMed id 12811541)1, 2 Olesen C....Tommerup N. (2003)
- Increased steroidogenic factor-1 dosage triggers adrenocortical cell proliferation and cancer. (PubMed id 17761949)1 Doghman M....Lalli E. (2007)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Immunohistochemical analysis of the expression of FAT E/BJ-HCC-2 antigen in normal and malignant tissues. (PubMed id 15580283)1 Yang X.A....Chen W.F. (2005)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
|
External Searches for FATE1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FATE1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FATE1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FATE1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FATE1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FATE1 gene:
Search GeneIP for patents involving FATE1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FATE1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FATE1 |
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