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FATE1 Gene(Protein Coding)

Fetal And Adult Testis Expressed 1

GCID:
GC0XP151716
GIFtS:
44
Genes Participants
UDN Logo

Aliases for FATE1 Gene

Aliases for FATE1 Gene

  • Fetal And Adult Testis Expressed 1 2 3 5
  • Cancer/Testis Antigen 43 2 3 4
  • Tumor Antigen BJ-HCC-2 3 4
  • CT43 3 4
  • FATE 3 4
  • Fetal And Adult Testis-Expressed Transcript Protein 3
  • BJ-HCC-2 Antigen 3

External Ids for FATE1 Gene

Previous GeneCards Identifiers for FATE1 Gene

  • GC0XP150555
  • GC0XP150884
  • GC0XP139741

Summaries for FATE1 Gene

Entrez Gene Summary for FATE1 Gene

  • This gene encodes a cancer-testis antigen that is highly expressed in hepatocellular carcinomas and other tumors and weakly expressed in normal tissues except testis. The protein is strongly expressed in spermatogonia, primary spermatocytes, and Sertoli cells in seminiferous tubules. This protein may have a role in the control of early testicular differentiation and cell proliferation. [provided by RefSeq, Jan 2010]

GeneCards Summary for FATE1 Gene

FATE1 (Fetal And Adult Testis Expressed 1) is a Protein Coding gene.

Gene Wiki entry for FATE1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FATE1 Gene

Genomics for FATE1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for FATE1 Gene

Enhancers for FATE1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG151702 0.7 ENCODE 8.2 -12.2 -12197 3.1 BACH1 MAFG DPF2 ARID1B ZFHX2 ZNF316 JUND SMARCA4 IKZF1 FOS PRRG3 FATE1
GH0XG151718 0.4 FANTOM5 7.5 +2.5 2478 0.0 ZNF512 CNGA2 FATE1 GC0XM151722
GH0XG151711 0.6 ENCODE 0.7 -4.2 -4208 0.7 ZNF146 ZNF407 BACH1 ZNF384 ZNF7 CBX5 RELB NFE2 MAFK EMSY FATE1 PRRG3
GH0XG151695 0.6 ENCODE 0.4 -19.2 -19152 2.6 RFX1 BHLHE40 MAFG BMI1 EP300 ZNF366 ZNF512 FOS NFE2 PRRG3 FATE1
GH0XG151696 0.2 ENCODE 0.3 -20.6 -20551 0.0 PRRG3 FATE1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FATE1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the FATE1 gene promoter:

Genomic Location for FATE1 Gene

Chromosome:
X
Start:
151,716,035 bp from pter
End:
151,723,194 bp from pter
Size:
7,160 bases
Orientation:
Plus strand

Genomic View for FATE1 Gene

Genes around FATE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FATE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FATE1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FATE1 Gene

Proteins for FATE1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FATE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969F0-FATE1_HUMAN
    Recommended name:
    Fetal and adult testis-expressed transcript protein
    Protein Accession:
    Q969F0

    Protein attributes for FATE1 Gene

    Size:
    183 amino acids
    Molecular mass:
    20712 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FATE1 Gene

Protein Expression for FATE1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FATE1 Gene

No Post-translational modifications

Other Protein References for FATE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for FATE1
  • Santa Cruz Biotechnology (SCBT) Antibodies for FATE1

No data available for DME Specific Peptides for FATE1 Gene

Domains & Families for FATE1 Gene

Protein Domains for FATE1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for FATE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FATE1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FATE1 Gene

Function for FATE1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Gene Ontology (GO) - Molecular Function for FATE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0031625 ubiquitin protein ligase binding IDA 26567849
genes like me logo Genes that share ontologies with FATE1: view
genes like me logo Genes that share phenotypes with FATE1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FATE1 Gene

Localization for FATE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FATE1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FATE1 gene
Compartment Confidence
mitochondrion 5
endoplasmic reticulum 4
plasma membrane 2
extracellular 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for FATE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane IDA 12865919
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FATE1: view

Pathways & Interactions for FATE1 Gene

SuperPathways for FATE1 Gene

PathCards logo More details on SuperPathways for FATE1
No Data Available

Gene Ontology (GO) - Biological Process for FATE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0043066 negative regulation of apoptotic process IDA 12865919
GO:0051562 negative regulation of mitochondrial calcium ion concentration IDA 12865919
genes like me logo Genes that share ontologies with FATE1: view

No data available for Pathways by source and SIGNOR curated interactions for FATE1 Gene

Drugs & Compounds for FATE1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for FATE1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for FATE1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(44) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FATE1 Gene

Fetal and adult testis expressed 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FATE1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for FATE1 Gene

GeneLoc Exon Structure for
FATE1
ECgene alternative splicing isoforms for
FATE1

Expression for FATE1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FATE1 Gene

mRNA expression in normal human tissues for FATE1 Gene
mRNA expression by GTEx for FATE1 Gene

mRNA differential expression in normal tissues according to GTEx for FATE1 Gene

This gene is overexpressed in Testis (x51.0).

Protein differential expression in normal tissues from HIPED for FATE1 Gene

This gene is overexpressed in Ovary (55.2) and Fetal ovary (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FATE1 Gene



Protein tissue co-expression partners for FATE1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FATE1 Gene:

FATE1

SOURCE GeneReport for Unigene cluster for FATE1 Gene:

Hs.301960

mRNA Expression by UniProt/SwissProt for FATE1 Gene:

Q969F0-FATE1_HUMAN
Tissue specificity: Testis-specific in fetus (aged from 6 to 11 weeks). In adult, expressed predominantly in testis, with some expression in lung, heart, kidney, adrenal gland and whole brain.
genes like me logo Genes that share expression patterns with FATE1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FATE1 Gene

Orthologs for FATE1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FATE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FATE1 34 35
  • 99.45 (n)
dog
(Canis familiaris)
 Mammalia FATE1 34 35
  • 78.87 (n)
cow
(Bos Taurus)
 Mammalia FATE1 35
  • 49 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Fate1 35
  • 48 (a)
 OneToOne
Species where no ortholog for FATE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FATE1 Gene

ENSEMBL:
Gene Tree for FATE1 (if available)
TreeFam:
Gene Tree for FATE1 (if available)

Paralogs for FATE1 Gene

No data available for Paralogs for FATE1 Gene

Variants for FATE1 Gene

Sequence variations from dbSNP and Humsavar for FATE1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000098596 -- 151,719,180(+) ATTAG(A/G)AAATC intron-variant
rs1000566062 -- 151,716,767(+) TGTTT(C/T)CTCTG intron-variant
rs1001411260 -- 151,720,117(+) AACCA(A/G)GAGTG intron-variant
rs1002080607 -- 151,717,494(+) CTAGA(C/T)GTTGA intron-variant
rs1002290591 -- 151,718,413(+) GGGGG(A/G)GGGAA intron-variant

Variation tolerance for FATE1 Gene

Residual Variation Intolerance Score: 54.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.87; 67.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FATE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FATE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FATE1 Gene

Disorders for FATE1 Gene

Relevant External Links for FATE1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FATE1

No disorders were found for FATE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FATE1 Gene

Publications for FATE1 Gene

  1. Human FATE is a novel X-linked gene expressed in fetal and adult testis. (PMID: 11694338) Olesen C. … Tommerup N. (Mol. Cell. Endocrinol. 2001) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Mutational analysis of the human FATE gene in 144 infertile men. (PMID: 12811541) Olesen C. … Tommerup N. (Hum. Genet. 2003) 3 4 64
  5. Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N. … Vidal M. (Cell 2015) 3 64

Products for FATE1 Gene

Sources for FATE1 Gene

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