Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAT4 Gene

protein-coding   GIFtS: 51
GCID: GC04P126237

FAT Atypical Cadherin 4

(Previous name: FAT tumor suppressor homolog 4 (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
FAT Atypical Cadherin 41 2     FAT Tumor Suppressor Homolog 4 (Drosophila)1
Cadherin-Related Family Member 111 2     CDHR112
Cadherin Family Member 142 3     FAT-J2
Fat-Like Cadherin Protein FAT-J2 3     NBLA005482
CDHF142 3     Fat-Like Cadherin FATJ2
FATJ2 3     Protocadherin Fat 42
FAT Tumor Suppressor Homolog 42 3     Putative Protein Product Of Nbla005482
hFat42 3     

External Ids:    HGNC: 231091   Entrez Gene: 796332   Ensembl: ENSG000001961597   OMIM: 6124115   UniProtKB: Q6V0I73   

Export aliases for FAT4 gene to outside databases

Previous GC identifers: GC00U912751 GC04P126673 GC04P126534 GC04P126457 GC04P121965


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAT4 Gene: 
FAT4 (FAT atypical cadherin 4) is a protein-coding gene. Diseases associated with FAT4 include urethral stricture, and lung adenoma. GO annotations related to this gene include protein binding and calcium ion binding. An important paralog of this gene is DCHS1.

UniProtKB/Swiss-Prot: FAT4_HUMAN, Q6V0I7
Function: May function in the regulation of planar cell polarity (By similarity). Cadherins are cell-cell
interaction molecules (By similarity)

Gene Wiki entry for FAT4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAT4 gene promoter:
         HOXA9   HOXA9B   HTF   Egr-1   MyoD   Meis-1b   Gfi-1   YY1   HFH-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FAT4 promoter sequence
   Search SABiosciences Chromatin IP Primers for FAT4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28.1   Ensembl cytogenetic band:  4q28.1   HGNC cytogenetic band: 4q28.1

FAT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAT4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P126237:  view genomic region     (about GC identifiers)

Start:
126,237,554 bp from pter      End:
126,414,087 bp from pter
Size:
176,534 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FAT4_HUMAN, Q6V0I7 (See protein sequence)
Recommended Name: Protocadherin Fat 4 precursor  
Size: 4981 amino acids; 542687 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential). Note=In the kidney, localizes to
primary cilia (By similarity)
Sequence caution: Sequence=BAB15534.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB15534.1; Type=Frameshift; Positions=4848; Sequence=BAF84150.1; Type=Erroneous initiation;
Secondary accessions: A8K5Z6 B5MDG4 Q3LIA6 Q8TCK7 Q9H5T6
Alternative splicing: 3 isoforms:  Q6V0I7-1   Q6V0I7-2   Q6V0I7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAT4: NX_Q6V0I7

Explore proteomics data for FAT4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6V0I7

  • FAT4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAT4 Protein Expression
    REFSEQ proteins: NP_078858.4  
    ENSEMBL proteins: 
     ENSP00000377862   ENSP00000335169  

    Human Recombinant Protein Products for FAT4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for FAT4
    GenScript Custom Purified and Recombinant Proteins Services for FAT4
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FAT4 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    FAT4 for ontologies           About GeneDecksing



    FAT4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for FAT4
    OriGene Custom Antibody Services for FAT4
    GenScript Custom Superior Antibodies Services for FAT4
    Novus Biologicals FAT4 Antibodies
    Abcam antibodies for FAT4
    Cloud-Clone Corp. Antibodies for FAT4 
    Search ThermoFisher Antibodies for FAT4
    LSBio Antibodies in human, mouse, rat for FAT4 

    Assay Products for FAT4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FAT4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FAT4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FAT4 
    Cloud-Clone Corp. CLIAs for FAT4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CDHR: Cadherins / Cadherin-related

    5/11 InterPro protein domains (see all 11):
     IPR000742 EG-like_dom
     IPR013320 ConA-like_subgrp
     IPR001791 Laminin_G
     IPR015919 Cadherin-like
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site

    Graphical View of Domain Structure for InterPro Entry Q6V0I7

    ProtoNet protein and cluster: Q6V0I7

    3 Blocks protein domains:
    IPB001791 Laminin G
    IPB002126 Cadherin
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: FAT4_HUMAN, Q6V0I7
    Similarity: Contains 34 cadherin domains
    Similarity: Contains 6 EGF-like domains
    Similarity: Contains 2 laminin G-like domains


    FAT4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FAT4_HUMAN, Q6V0I7
    Function: May function in the regulation of planar cell polarity (By similarity). Cadherins are cell-cell
    interaction molecules (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI--
         
    FAT4 for ontologies           About GeneDecksing


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Fat4):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  growth/size 
     hearing/vestibular/ear  limbs/digits/tail  mortality/aging  nervous system  no phenotypic analysis 
     renal/urinary system  respiratory system  skeleton 

    FAT4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FAT4: Fat4tm1.1Hmc Fat4tm2Hmc

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FAT4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FAT4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAT4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAT4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FAT4
    8/71 QIAGEN miScript miRNA Assays for microRNAs that regulate FAT4 (see all 71):
    hsa-miR-548j hsa-miR-520e hsa-miR-193a-3p hsa-miR-106a hsa-miR-15a hsa-miR-3074-3p hsa-miR-93 hsa-miR-3613-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FAT4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAT4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FAT4


    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for FAT4 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAT4 (NM_024582)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAT4
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAT4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FAT4
    Search LifeMap BioReagents cell lines for FAT4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAT4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAT4

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/10 Interacting proteins for FAT4 (Q6V0I71, 2, 3 ENSP000003778624) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542532, 3, ENSP000002447694MINT-2876323 I2D: score=3 STRING: ENSP00000244769
    DCHS1Q96JQ03, ENSP000002994414I2D: score=1 STRING: ENSP00000299441
    RYKP349253, ENSP000002960844I2D: score=1 STRING: ENSP00000296084
    TNKS2Q9H2K21, ENSP000003606894EBI-948985,EBI-4398527 STRING: ENSP00000360689
    CTNNB1P352223, ENSP000003444564I2D: score=1 STRING: ENSP00000344456
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007156homophilic cell adhesion IEA--

    FAT4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAT4

    Search CenterWatch for drugs/clinical trials and news about FAT4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAT4 gene: 
    NM_024582.4  

    Unigene Cluster for FAT4:

    FAT tumor suppressor homolog 4 (Drosophila)
    Hs.563205  [show with all ESTs]
    Unigene Representative Sequence: NM_024582
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394329(uc003ifj.4 uc011cgp.2 uc003ifi.1) ENST00000335110
    ENST00000509444
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FAT4
    8/71 QIAGEN miScript miRNA Assays for microRNAs that regulate FAT4 (see all 71):
    hsa-miR-548j hsa-miR-520e hsa-miR-193a-3p hsa-miR-106a hsa-miR-15a hsa-miR-3074-3p hsa-miR-93 hsa-miR-3613-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FAT4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAT4
    Clone
    Products:
         
    OriGene clones in human, mouse for FAT4 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAT4 (NM_024582)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAT4
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAT4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FAT4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAT4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAT4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAT4

    Additional mRNA sequence: 

    AB075518.1 AK026709.1 AK091292.1 AK096646.1 AK291461.1 AL713715.1 AY356402.1 

    5 DOTS entries:

    DT.310598  DT.40110237  DT.100742156  DT.40289033  DT.306365 

    24/60 AceView cDNA sequences (see all 60):

    CR610468 AW955781 NM_024582 AY356402 AK096646 AI500084 AL713715 BM681989 
    N45570 Z40669 AI221651 CB129890 CA413337 AI041710 BG680702 AA334944 
    AK091292 AI559896 AA406344 BX117858 AK026709 AI808424 F07623 AW105190 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAT4 expression in normal human tissues (normalized intensities)      FAT4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTCCCCAG
    FAT4 Expression
    About this image


    FAT4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Umbilical cord blood-derived mesenchymal stem cells
             cd49a+ cells   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             superior temporal gyrus   
     
     Kidney (Urinary System)
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
     
     Lower Urinary Tract (Urinary System)
             urethra   
     
     Cartilage (Muscoskeletal System)
             synovial membrane   

    See FAT4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAT4

    SOURCE GeneReport for Unigene cluster: Hs.563205

    UniProtKB/Swiss-Prot: FAT4_HUMAN, Q6V0I7
    Tissue specificity: Widely expressed. Expressed in fetal brain, infant brain, brain tumor and colorectal cancer

        SABiosciences Expression via Pathway-Focused PCR Arrays including FAT4: 
              Hedgehog Signaling Pathway in human mouse rat
              Primary Cilia in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FAT4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAT4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAT4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAT4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAT4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FAT4 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fat41 , 5 FAT tumor suppressor homolog 4 (Drosophila)1, 5 83.41(n)1
    91.42(a)1
      3 (18.72 cM)5
    3296281  NM_183221.31  NP_899044.31 
     388869405 
    chicken
    (Gallus gallus)
    Aves FAT41 FAT tumor suppressor homolog 4 (Drosophila) 76.48(n)
    83.32(a)
      395166  XM_420617.3  XP_420617.3 
    lizard
    (Anolis carolinensis)
    Reptilia FAT46
    Uncharacterized protein
    79(a)
    1 ↔ 1
    5(137392248-137552330)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.262752 Xenopus laevis transcribed sequences 87.66(n)    BJ082657.1 
    zebrafish
    (Danio rerio)
    Actinopterygii FAT46
    AL929092.36
    Uncharacterized protein
    69(a)
    40(a)
    1 ↔ 1
    possible ortholog
    14(389579-456589)
    15(30795768-30797799)
    fruit fly
    (Drosophila melanogaster)
    Insecta ft1 fat 46.01(n)
    38.73(a)
      33627  NM_058149.3  NP_477497.1 


    ENSEMBL Gene Tree for FAT4 (if available)
    TreeFam Gene Tree for FAT4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAT4 gene
    DCHS12  CDHR22  DCHS22  CELSR32  CELSR12  FAT22  CDHR12  PCDH152  
    FAT32  CELSR22  FAT12  
    17 SIMAP similar genes for FAT4 using alignment to 1 protein entry:     FAT4_HUMAN:
    F9    ME5    FAT3    ME4    ME2    CDH22
    ME6    Nbla04261    FLJ00233    DKFZp434P2350    ME1    CDH23
    DKFZp586I1919    NOTCH2NL    ME3    PCDHGA3    PCDHGA6

    FAT4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3737 SNPs in FAT4 are shown (see all 3737)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs607303411,2
    C--122121388(+) AAAAA-/A/AAA 
            
    TTAGC
    1 -- int11NA 2
    rs58617271,2
    C--126190334(+) TTCCG-/TT/TT 
     T
    /TTTTT
    TTTTT
    2 -- int1 cds11NA 2
    rs1510690711,2
    --126235637(+) TTCCTC/TCCCGC 1 -- us2k10--------
    rs1409724791,2
    C--126235642(+) CCCCGC/TTTTAA 1 -- us2k10--------
    rs359799711,2
    F--126235848(+) AAAGGA/-AAAAA 1 -- us2k12Minor allele frequency- -:0.50NA CSA 4
    rs1449026481,2
    C--126235871(+) AAAAG-/AAAAAA 1 -- us2k10--------
    rs2016055661,2
    --126235877(+) AAAAA-/GAATCA 1 -- us2k10--------
    rs1843618771,2
    --126236025(+) CGGTCC/GGGGCT 1 -- us2k10--------
    rs1897747351,2
    --126236138(+) AGTGTC/GGAGCA 1 -- us2k10--------
    rs726732761,2
    C,F--126236140(+) TGTCGA/GGCAAA 1 -- us2k12Minor allele frequency- G:0.07NA EA 240

    HapMap Linkage Disequilibrium report for FAT4 (126237554 - 126414087 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FAT4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830051CNV Loss17160897
    nsv470070CNV Loss18288195

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FAT4
    DNA2.0 Custom Variant and Variant Library Synthesis for FAT4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612411    OMIM disorders: --

    11 diseases for FAT4:    About MalaCards
    urethral stricture    lung adenoma    cherubism    urethritis
    major depressive disorder    gastric adenocarcinoma    adenoma    neuroblastoma
    colorectal cancer    adenocarcinoma    breast cancer


    FAT4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FAT4
    Human Genome Epidemiology (HuGE) Navigator: FAT4 (2 documents)

    Export disorders for FAT4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAT4 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with FAT4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of new human cadherin genes using a combination of protein motif search and gene finding methods. (PubMed id 15003449)1, 2, 3, 9 Hoeng J.C.... Liu Y. (2004)
    2. Meta-analysis of genome-wide association data of bipo lar disorder and major depressive disorder. (PubMed id 20351715)1, 4 Liu Y....Sullivan P.F. (2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. A genome-wide study of common SNPs and CNVs in cognit ive performance in the CANTAB. (PubMed id 19734545)1, 4 Need A.C....Goldstein D.B. (2009)
    5. Comparative integromics on FAT1, FAT2, FAT3 and FAT4. (PubMed id 16865240)1, 2 Katoh Y. and Katoh M. (2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Nonsynonymous polymorphisms in FAT4 gene are associate d with the risk of esophageal cancer in an Eastern Chinese population. (PubMed id 23319386)1 Du J....Shen H. (2013)
    8. Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes. (PubMed id 22484628)1 Zang Z.J....Tan P. (2012)
    9. Mindbomb 1, an E3 ubiquitin ligase, forms a complex w ith RYK to activate Wnt/I^-catenin signaling. (PubMed id 21875946)1 Berndt J.D....Moon R.T. (2011)
    10. Identification of Fat4 as a candidate tumor suppressor gene in breast cancers. (PubMed id 19048595)1 Qi C....Zhu Y.J. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79633 HGNC: 23109 AceView: FATJ Ensembl:ENSG00000196159 euGenes: HUgn79633
    ECgene: FAT4 H-InvDB: FAT4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAT4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FAT4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAT4 gene:
    Search GeneIP for patents involving FAT4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for FAT4   OriGene RNAi products in human, mouse, rat for FAT4  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FAT4  
     OriGene qSTAR qPCR primer pairs in human, mouse for FAT4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FAT4   OriGene Custom Protein Services for FAT4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAT4
     QIAGEN SeqTarget long-range PCR primers for resequencing FAT4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAT4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAT4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAT4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAT4
     GenScript Custom Purified and Recombinant Proteins Services for FAT4 GenScript cDNA clones with any tag delivered in your preferred vector for FAT4
     GenScript Custom Assay Services for FAT4 GenScript Custom Superior Antibodies Services for FAT4
     GenScript Custom overexpressing Cell Line Services for FAT4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FAT4 promoter
     Search Chromatin IP Primers for FAT4
     RT2 qPCR Primer Assay in human, mouse, rat FAT4
     Search GNC Networks for FAT4
     SABiosciences PCR Arrays including human, mouse, rat FAT4
     Search Tocris compounds for FAT4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FAT4 antibodies
     Antibodies for FAT4
     See all of Abcam's Antibodies, Kits and Proteins for FAT4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for FAT4
     Antibodies for FAT4
     ELISAs for FAT4
     CLIAs for FAT4
     Search LifeMap BioReagents cell lines for FAT4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAT4
     Browse SwitchGear 3'UTR luciferase reporter plasmids for FAT4
     SwitchGear Promoter luciferase reporter plasmids for FAT4
     Search ThermoFisher Antibodies for FAT4
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAT4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for FAT4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FAT4
    Customized:
     lentivirus for stable overexpression
     lentivirus expression plasmids for stable overexpression
     adenovirus for overexpression
     LSBio Antibodies in human, mouse, rat for FAT4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FAT4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4