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Aliases for FAT3 Gene

Aliases for FAT3 Gene

  • FAT Atypical Cadherin 3 2 3 5
  • Cadherin-Related Family Member 10 2 3
  • FAT Tumor Suppressor Homolog 3 3 4
  • Cadherin Family Member 15 3 4
  • CDHF15 3 4
  • HFat3 3 4
  • FAT Tumor Suppressor Homolog 3 (Drosophila) 2
  • KIAA1989 4
  • CDHR10 3

External Ids for FAT3 Gene

Previous GeneCards Identifiers for FAT3 Gene

  • GC11P094904
  • GC11P094081
  • GC11P092758
  • GC11P092048
  • GC11P091942
  • GC11P092164
  • GC11P091723
  • GC11P088175

Summaries for FAT3 Gene

GeneCards Summary for FAT3 Gene

FAT3 (FAT Atypical Cadherin 3) is a Protein Coding gene. Diseases associated with FAT3 include benign meningioma. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is FAT4.

UniProtKB/Swiss-Prot for FAT3 Gene

  • May play a role in the interactions between neurites derived from specific subsets of neurons during development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAT3 Gene

Genomics for FAT3 Gene

Regulatory Elements for FAT3 Gene

Enhancers for FAT3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAT3 on UCSC Golden Path with GeneCards custom track

Genomic Location for FAT3 Gene

Chromosome:
11
Start:
92,314,283 bp from pter
End:
92,896,470 bp from pter
Size:
582,188 bases
Orientation:
Plus strand

Genomic View for FAT3 Gene

Genes around FAT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAT3 Gene

Proteins for FAT3 Gene

  • Protein details for FAT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDW7-FAT3_HUMAN
    Recommended name:
    Protocadherin Fat 3
    Protein Accession:
    Q8TDW7
    Secondary Accessions:
    • B5MDB0
    • Q96AU6

    Protein attributes for FAT3 Gene

    Size:
    4589 amino acids
    Molecular mass:
    505523 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH16722.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAT3 Gene

Proteomics data for FAT3 Gene at MOPED

Post-translational modifications for FAT3 Gene

  • Glycosylation at Asn 49, Asn 342, Asn 482, Asn 563, Asn 668, Asn 800, Asn 880, Asn 899, Asn 1007, Asn 1368, Asn 1430, Asn 1752, Asn 1945, Asn 1994, Asn 1997, Asn 2209, Asn 2293, Asn 2332, Asn 2468, Asn 3001, Asn 3202, Asn 3330, Asn 3450, Asn 3619, Asn 3742, and Asn 3927
  • Modification sites at PhosphoSitePlus

Other Protein References for FAT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAT3 Gene

Domains & Families for FAT3 Gene

Gene Families for FAT3 Gene

Suggested Antigen Peptide Sequences for FAT3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TDW7

UniProtKB/Swiss-Prot:

FAT3_HUMAN :
  • Contains 33 cadherin domains.
Domain:
  • Contains 33 cadherin domains.
  • Contains 4 EGF-like domains.
  • Contains 1 laminin G-like domain.
genes like me logo Genes that share domains with FAT3: view

Function for FAT3 Gene

Molecular function for FAT3 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the interactions between neurites derived from specific subsets of neurons during development.
genes like me logo Genes that share phenotypes with FAT3: view

Animal Models for FAT3 Gene

MGI Knock Outs for FAT3:

Animal Model Products

  • Taconic Biosciences Mouse Models for FAT3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAT3 Gene

Localization for FAT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAT3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAT3 Gene COMPARTMENTS Subcellular localization image for FAT3 gene
Compartment Confidence
plasma membrane 4
cytosol 2
nucleus 2
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for FAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAT3: view

Pathways & Interactions for FAT3 Gene

SuperPathways for FAT3 Gene

No Data Available

Interacting Proteins for FAT3 Gene

Selected Interacting proteins: Q8TDW7-FAT3_HUMAN for FAT3 Gene via I2D

Symbol External ID(s) Details
RYK

Gene Ontology (GO) - Biological Process for FAT3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAT3 Gene

Drugs & Compounds for FAT3 Gene

No Compound Related Data Available

Transcripts for FAT3 Gene

Unigene Clusters for FAT3 Gene

FAT tumor suppressor homolog 3 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAT3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - - -
SP2:
SP3:

Relevant External Links for FAT3 Gene

GeneLoc Exon Structure for
FAT3
ECgene alternative splicing isoforms for
FAT3

Expression for FAT3 Gene

mRNA expression in normal human tissues for FAT3 Gene

mRNA differential expression in normal tissues according to GTEx for FAT3 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x7.4), Brain - Caudate (basal ganglia) (x5.2), and Brain - Putamen (basal ganglia) (x4.5).

Protein differential expression in normal tissues from HIPED for FAT3 Gene

This gene is overexpressed in Plasma (55.7) and Fetal Brain (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for FAT3 Gene



SOURCE GeneReport for Unigene cluster for FAT3 Gene Hs.98523

mRNA Expression by UniProt/SwissProt for FAT3 Gene

Q8TDW7-FAT3_HUMAN
Tissue specificity: Expressed in ES cells, primitive neuroectoderm, fetal brain, infant brain, adult neural tissues and prostate.
genes like me logo Genes that share expression patterns with FAT3: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for FAT3 Gene

Orthologs for FAT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FAT3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAT3 35
  • 88.82 (n)
  • 93.3 (a)
FAT3 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAT3 35
  • 91.29 (n)
  • 95.55 (a)
FAT3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fat3 35
  • 87.09 (n)
  • 92.62 (a)
Fat3 16
Fat3 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAT3 35
  • 99.55 (n)
  • 99.58 (a)
FAT3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fat3 35
  • 87.11 (n)
  • 93 (a)
oppossum
(Monodelphis domestica)
Mammalia FAT3 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAT3 36
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAT3 35
  • 78.47 (n)
  • 87.07 (a)
FAT3 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAT3 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fat3 35
  • 72.66 (n)
  • 78.95 (a)
Str.5146 35
zebrafish
(Danio rerio)
Actinopterygii LOC568600 35
  • 61.94 (n)
  • 59.52 (a)
fat3a 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta kug 36
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToOne
Species with no ortholog for FAT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAT3 Gene

ENSEMBL:
Gene Tree for FAT3 (if available)
TreeFam:
Gene Tree for FAT3 (if available)

Paralogs for FAT3 Gene

Paralogs for FAT3 Gene

genes like me logo Genes that share paralogs with FAT3: view

Variants for FAT3 Gene

Sequence variations from dbSNP and Humsavar for FAT3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10830902 - 92,353,347(+) ATTAT(C/T)TCCTG reference, missense
rs16917409 - 92,353,496(+) TCAGC(A/G/T)TAGAA reference, missense
rs11821058 - 92,524,841(+) ATCTG(G/T)CATTC reference, missense
rs7949157 - 92,798,190(+) CACTC(A/G)GAAGG reference, missense
rs16918105 - 92,799,891(+) ATACA(A/G/T)TACAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FAT3 Gene

Variant ID Type Subtype PubMed ID
nsv898173 CNV Loss 21882294
nsv832230 CNV Gain 17160897
nsv509437 CNV Insertion 20534489
esv1282231 CNV Insertion 17803354
esv2500510 CNV Deletion 19546169
esv2148422 CNV Deletion 18987734
esv2668744 CNV Deletion 23128226
esv2744908 CNV Deletion 23290073
nsv38845 CNV Loss 16902084
esv2493372 CNV Deletion 19546169
esv7974 CNV Loss 19470904
nsv832231 CNV Gain 17160897
nsv521791 CNV Loss 19592680
esv2744909 CNV Deletion 23290073
esv2667352 CNV Deletion 23128226
nsv432 CNV Insertion 18451855
esv2663237 CNV Deletion 23128226
esv2744910 CNV Deletion 23290073
esv1073574 CNV Insertion 17803354
esv1024754 CNV Insertion 17803354
esv1228564 CNV Insertion 17803354
esv5400 CNV Complex 18987735
esv269004 CNV Insertion 20981092
esv272909 CNV Insertion 20981092
esv1007859 CNV Insertion 20482838
esv1420122 CNV Insertion 17803354
nsv898175 CNV Loss 21882294

Variation tolerance for FAT3 Gene

Gene Damage Index Score: 8.40; 85.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAT3 Gene

HapMap Linkage Disequilibrium report
FAT3
Human Gene Mutation Database (HGMD)
FAT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAT3 Gene

Disorders for FAT3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAT3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
benign meningioma
  • meningioma, benign
- elite association - COSMIC cancer census association via MalaCards
Search FAT3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FAT3

Genetic Association Database (GAD)
FAT3
Human Genome Epidemiology (HuGE) Navigator
FAT3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAT3
genes like me logo Genes that share disorders with FAT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAT3 Gene

Publications for FAT3 Gene

  1. Mammalian fat3: a large protein that contains multiple cadherin and EGF-like motifs. (PMID: 11811999) Mitsui K. … Nakayama M. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. (PMID: 24529757) Xie T. … Xu R. (Neurobiol. Aging 2014) 3
  4. Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits. (PMID: 24204828) Zheng J.S. … Lai C.Q. (PLoS ONE 2013) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for FAT3 Gene

Sources for FAT3 Gene

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