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FAT3 Gene

protein-coding   GIFtS: 51
GCID: GC11P092164

FAT Atypical Cadherin 3

(Previous name: FAT tumor suppressor homolog 3 (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FAT Atypical Cadherin 31 2     hFat32 3
Cadherin-Related Family Member 101 2     FAT Tumor Suppressor Homolog 3 (Drosophila)1
Cadherin Family Member 152 3     CDHR102
CDHF152 3     Protocadherin Fat 32
FAT Tumor Suppressor Homolog 32 3     KIAA19893

External Ids:    HGNC: 231121   Entrez Gene: 1201142   Ensembl: ENSG000001653237   OMIM: 6124835   UniProtKB: Q8TDW73   

Export aliases for FAT3 gene to outside databases

Previous GC identifers: GC11P094904 GC11P094081 GC11P092758 GC11P092048 GC11P091942 GC11P091723 GC11P088175


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAT3 Gene:
FAT3 (FAT atypical cadherin 3) is a protein-coding gene. Diseases associated with FAT3 include benign meningioma, and meningioma. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is DCHS1.

UniProtKB/Swiss-Prot: FAT3_HUMAN, Q8TDW7
Function: May play a role in the interactions between neurites derived from specific subsets of neurons during
development (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAT3 gene promoter:
         E2F-4   E2F-3a   E2F-5   RP58   Nkx2-5   E2F-2   Gfi-1   S8   E2F   E2F-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FAT3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.3   Ensembl cytogenetic band:  11q14.3   HGNC cytogenetic band: 11q14.3

FAT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAT3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P092164:  view genomic region     (about GC identifiers)

Start:
92,085,262 bp from pter      End:
92,629,636 bp from pter
Size:
544,375 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FAT3_HUMAN, Q8TDW7 (See protein sequence)
Recommended Name: Protocadherin Fat 3 precursor  
Size: 4589 amino acids; 505523 Da
Sequence caution: Sequence=AAH16722.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B5MDB0 Q96AU6
Alternative splicing: 3 isoforms:  Q8TDW7-1   Q8TDW7-2   Q8TDW7-3   (Gene prediction based on similarity to rat ortholog and partial EST and cDNA data)

Explore the universe of human proteins at neXtProt for FAT3: NX_Q8TDW7

Explore proteomics data for FAT3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn49, Asn342, Asn482, Asn563, Asn668, Asn800, Asn880, Asn899, Asn1007, Asn1368,
                                 Asn1430, Asn1752, Asn1945, Asn1994, Asn1997, Asn2209, Asn2293, Asn2332, Asn2468, Asn3001 (see all 26)
  • Modification sites at PhosphoSitePlus

  • See FAT3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001008781.2  
    ENSEMBL proteins: 
     ENSP00000432586   ENSP00000436399   ENSP00000298047   ENSP00000387040   ENSP00000443786  

    FAT3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for FAT3

    FAT3 Antibody Products:

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    Abcam antibodies for FAT3
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    FAT3 Assay Products:

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    Cloud-Clone Corp. CLIAs for FAT3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CDHR: Cadherins / Cadherin-related

    Selected InterPro protein domains (see all 11):
     IPR000742 EG-like_dom
     IPR013320 ConA-like_subgrp
     IPR001791 Laminin_G
     IPR015919 Cadherin-like
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site

    Graphical View of Domain Structure for InterPro Entry Q8TDW7

    ProtoNet protein and cluster: Q8TDW7

    3 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB001791 Laminin G
    IPB001881 EGF-like calcium-binding


    UniProtKB/Swiss-Prot: FAT3_HUMAN, Q8TDW7
    Similarity: Contains 33 cadherin domains
    Similarity: Contains 4 EGF-like domains
    Similarity: Contains 1 laminin G-like domain


    FAT3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FAT3_HUMAN, Q8TDW7
    Function: May play a role in the interactions between neurites derived from specific subsets of neurons during
    development (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    FAT3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for FAT3:
     Decreased Wnt reporter activit  Increased G1 DNA content  Synthetic lethal with c-Myc af 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fat3):
     nervous system  vision/eye 

    FAT3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fat3tm1.2Good for FAT3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAT3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FAT3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAT3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAT3

    miRNA
    Products:
        
    miRTarBase miRNAs that target FAT3:
    hsa-mir-130b-3p (MIRT020303), hsa-mir-1303 (MIRT035881), hsa-mir-19b-3p (MIRT031285), hsa-mir-132-3p (MIRT021824), hsa-mir-16-5p (MIRT031999), hsa-mir-296-3p (MIRT038339)

    Block miRNA regulation of human, mouse, rat FAT3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAT3 (see all 113):
    hsa-miR-579 hsa-miR-26a-2* hsa-miR-607 hsa-miR-520f hsa-miR-199a-3p hsa-miR-106a hsa-miR-128 hsa-miR-200a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FAT3
    Predesigned siRNA for gene silencing in human, mouse, rat FAT3

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for FAT3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAT3 (NM_001008781)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAT3
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAT3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for FAT3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAT3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FAT3_HUMAN, Q8TDW7: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol1
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    FAT3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAT3
    Interactions:

        Search GeneGlobe Interaction Network for FAT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for FAT3 (Q8TDW73 ENSP000003870404) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RYKP349253, ENSP000002960844I2D: score=1 STRING: ENSP00000296084
    VGLL2ENSP000003209574STRING: ENSP00000320957
    DCHS1ENSP000002994414STRING: ENSP00000299441
    DCHS2ENSP000003497684STRING: ENSP00000349768
    BMP2ENSP000003681044STRING: ENSP00000368104
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007156homophilic cell adhesion IEA--
    GO:0007275multicellular organismal development IEA--

    FAT3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAT3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FAT3 gene: 
    NM_001008781.2  

    Unigene Cluster for FAT3:

    FAT tumor suppressor homolog 3 (Drosophila)
    Hs.98523  [show with all ESTs]
    Unigene Representative Sequence: NM_001008781
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000525166 ENST00000528921 ENST00000533797 ENST00000489716 ENST00000469900
    ENST00000298047(uc001pdi.4) ENST00000409404(uc001pdj.4) ENST00000541502

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FAT3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAT3 (see all 113):
    hsa-miR-579 hsa-miR-26a-2* hsa-miR-607 hsa-miR-520f hsa-miR-199a-3p hsa-miR-106a hsa-miR-128 hsa-miR-200a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FAT3
    Predesigned siRNA for gene silencing in human, mouse, rat FAT3
    Clone
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    OriGene clones in human, mouse for FAT3 (see all 4)
    OriGene ORF clones in mouse, rat for FAT3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAT3 (NM_001008781)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAT3
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAT3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FAT3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAT3
      QuantiTect SYBR Green Assays in human, mouse, rat FAT3
      QuantiFast Probe-based Assays in human, mouse, rat FAT3

    Additional mRNA sequence: 

    AB076400.1 AK054903.1 AK091570.1 AK126620.1 AK127104.1 BC016722.1 

    9 DOTS entries:

    DT.310671  DT.40229255  DT.91894902  DT.95081084  DT.95100518  DT.91963260  DT.120695867  DT.120695875 
    DT.75188305 

    Selected AceView cDNA sequences (see all 36):

    AA348584 AA348585 BQ017006 AB076400 AW270140 AK091570 AX747066 AA844712 
    AI283093 H45360 Z44499 BE350126 AI074724 BX953728 AA447364 BQ003884 
    AK126620 AA443397 BX643204 AA464854 AW663950 AA428213 F07323 AK127104 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FAT3    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
    SP1:                                                        -           -     -         
    SP2:                                                                                    
    SP3:                                                                                    


    ECgene alternative splicing isoforms for FAT3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FAT3 Expression
    About this image


    FAT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Metencephalon
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 4 entries
             hIPS1
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
             Midbrain dopaminergic-like neurons
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
             Midbrain dopaminergic-like neurons
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             GABAergic Amacrine Cells Inner Nuclear Layer
    FAT3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAT3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.98523

    UniProtKB/Swiss-Prot: FAT3_HUMAN, Q8TDW7
    Tissue specificity: Expressed in ES cells, primitive neuroectoderm, fetal brain, infant brain, adult neural
    tissues and prostate

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FAT3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fat31 , 5 FAT tumor suppressor homolog 3 (Drosophila)1, 5 87.09(n)1
    92.62(a)1
      9 (5.16 cM)5
    2701201  NM_001080814.11  NP_001074283.11 
     159102055 
    chicken
    (Gallus gallus)
    Aves FAT31 FAT tumor suppressor homolog 3 (Drosophila) 78.47(n)
    87.07(a)
      395167  NM_001111323.1  NP_001104793.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAT36
    FAT atypical cadherin 3
    45(a)
    1 ↔ 1
    1(152248939-152312616)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.51462 Transcribed sequence with weak similarity to protein more 77.34(n)    BQ394201.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5686001 protocadherin Fat 3-like 61.94(n)
    59.52(a)
      568600  XM_003199357.2  XP_003199405.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta kug6
    kugelei
    36(a)
    1 → many
    3L(19999684-20017707)


    ENSEMBL Gene Tree for FAT3 (if available)
    TreeFam Gene Tree for FAT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAT3 gene
    DCHS12  DCHS22  CELSR32  CELSR12  FAT22  PCDH152  FAT42  CELSR22  
    FAT12  
    Selected SIMAP similar genes for FAT3 using alignment to 5 protein entries:     FAT3_HUMAN (see all proteins) (see all similar genes):
    ME5    ZNF564    CTSS    TMEM14B    ZNF737    LYRM4
    SHANK2    TIMM23B    ZNF738    PCDHGC5    ZNF547    CDHR2
    FAM175A    LINC00596    PCDH24    RNF217    SPATS2L    TSEN2

    FAT3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAT3 (see all 10997)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs676001451,2
    C--88477465(-) TAGGA-/ACTT  
            
    ACAGG
    1 -- int11Minor allele frequency- ACTT:0.00NA 2
    rs1490551091,2
    --92083504(+) ATATGC/TTAAAC 1 -- us2k10--------
    rs343160151,2
    C--92083513(+) ACTCC-/TGTAGG 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs355147491,2
    C--92083520(+) TAGGG-/ATTTTT 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs781689201,2
    --92083520(+) TAGGGA/TTTTTT 1 -- us2k10--------
    rs1817257561,2
    --92083525(+) ATTTTC/TTTTTT 1 -- us2k10--------
    rs786791221,2
    C--92083533(+) TTTTTC/TCAGTT 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1421304781,2
    --92083684(+) TTCTAC/GGATCC 1 -- us2k10--------
    rs678157701,2
    C,F--92083756(+) CATGGA/GTTTTA 1 -- us2k18Minor allele frequency- G:0.19NA WA CSA EA 250
    rs1511429711,2
    --92083848(+) ATTAAA/CTTCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FAT3 (92085262 - 92335262 bp, first 250kb of FAT3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FAT3 (see all 27):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2500510CNV Deletion19546169
    esv2744908CNV Deletion23290073
    esv2668744CNV Deletion23128226
    esv2744909CNV Deletion23290073
    esv2663237CNV Deletion23128226
    esv2148422CNV Deletion18987734
    esv2667352CNV Deletion23128226
    esv2493372CNV Deletion19546169
    esv2744910CNV Deletion23290073
    nsv432CNV Insertion18451855

    Human Gene Mutation Database (HGMD): FAT3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAT3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612483    OMIM disorders: --

    5 diseases for FAT3:    
    About MalaCards
    benign meningioma    meningioma    prostatitis    cerebritis
    neuronitis


    FAT3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FAT3
    Human Genome Epidemiology (HuGE) Navigator: FAT3 (1 document)

    Export disorders for FAT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAT3 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with FAT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian fat3: a large protein that contains multiple cadherin and EGF-like motifs. (PubMed id 11811999)1, 2, 3 Mitsui K.... Nakayama M. (Biochem. Biophys. Res. Commun. 2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    4. Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/I^-catenin signaling. (PubMed id 21875946)1 Berndt J.D....Moon R.T. (J. Cell Biol. 2011)
    5. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PubMed id 17903306)4 Newton-Cheh C....Larson M.G. (BMC Med. Genet. 2007)
    6. Genome-wide association with diabetes-related traits in the Framingham Heart Study. (PubMed id 17903298)4 Meigs J.B....Dupuis J. (BMC Med. Genet. 2007)
    7. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PubMed id 17903292)4 Hwang S.J....Fox C.S. (BMC Med. Genet. 2007)
    8. Comparative integromics on FAT1, FAT2, FAT3 and FAT4. (PubMed id 16865240)2 Katoh Y. and Katoh M. (Int. J. Mol. Med. 2006)
    9. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    10. Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes. (PubMed id 15744052)1 Wu Q. (Genetics 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 120114 HGNC: 23112 AceView: FAT3 Ensembl:ENSG00000165323 euGenes: HUgn120114
    ECgene: FAT3 H-InvDB: FAT3

    (According to HUGE)
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    HUGE: KIAA1989

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAT3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FAT3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAT3 gene:
    Search GeneIP for patents involving FAT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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