Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FAT2 Gene

protein-coding   GIFtS: 50
GCID: GC05M150883

FAT Atypical Cadherin 2

(Previous names: FAT tumor suppressor (Drosophila) homolog 2, FAT tumor suppressor...)
  See FAT2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
FAT Atypical Cadherin 21 2     CDHR92
MEGF12 3 5     HFAT22
Cadherin-Related Family Member 91 2     FAT Tumor Suppressor Homolog 22
Cadherin Family Member 82 3     Multiple Epidermal Growth Factor-Like Domains 12
Multiple EGF-Like Domains Protein 12 3     Protocadherin Fat 22
Multiple Epidermal Growth Factor-Like Domains Protein 12 3     Protocadherin FAT22
CDHF82 3     KIAA08113
FAT Tumor Suppressor (Drosophila) Homolog 21     hFat23
FAT Tumor Suppressor Homolog 2 (Drosophila)1     

External Ids:    HGNC: 35961   Entrez Gene: 21962   Ensembl: ENSG000000865707   OMIM: 6042695   UniProtKB: Q9NYQ83   

Export aliases for FAT2 gene to outside databases

Previous GC identifers: GC05M150952 GC05M151480 GC05M150912 GC05M150863 GC05M146029


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FAT2 Gene:
This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor
essential for controlling cell proliferation during Drosophila development. The gene product is a member of the
cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type
repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth
factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion
molecule, controlling cell proliferation and playing an important role in cerebellum development. (provided by
RefSeq, Jul 2008)

GeneCards Summary for FAT2 Gene:
FAT2 (FAT atypical cadherin 2) is a protein-coding gene. Diseases associated with FAT2 include skin squamous cell carcinoma. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is DCHS1.

UniProtKB/Swiss-Prot: FAT2_HUMAN, Q9NYQ8
Function: Plays a role in the migration of epidermal cells. May modulate the extracellular space surronding
parallel fibers of cerebellar during development (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_029289.12  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAT2 gene promoter:
         GR   GR-beta   SREBP-1c   Olf-1   GATA-1   C/EBPalpha   SREBP-1b   SREBP-1a   HOXA5   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAT2 promoter sequence
   Search Chromatin IP Primers for FAT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.1   Ensembl cytogenetic band:  5q33.1   HGNC cytogenetic band: 5q33.1

FAT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAT2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M150883:  view genomic region     (about GC identifiers)

Start:
150,883,653 bp from pter      End:
150,948,505 bp from pter
Size:
64,853 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FAT2_HUMAN, Q9NYQ8 (See protein sequence)
Recommended Name: Protocadherin Fat 2 precursor  
Size: 4349 amino acids; 479317 Da
Subunit: Homodimer (By similarity)
Secondary accessions: O75091 Q9NSR7

Explore the universe of human proteins at neXtProt for FAT2: NX_Q9NYQ8

Explore proteomics data for FAT2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn39, Asn210, Asn280, Asn330, Asn459, Asn568, Asn627, Asn655, Asn789, Asn996,
                                 Asn1175, Asn1383, Asn1417, Asn1904, Asn1998, Asn2007, Asn2165, Asn2183, Asn2325, Asn2368 (see all 39)
  • Modification sites at PhosphoSitePlus

  • See FAT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001438.1  
    ENSEMBL proteins: 
     ENSP00000429678   ENSP00000261800  

    FAT2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for FAT2
    GenScript Custom Purified and Recombinant Proteins Services for FAT2
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for FAT2 

     
    Search antibodies-online for proteins for FAT2 

     
    Search antibodies-online for peptides for FAT2

    FAT2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FAT2
    Search for Antibodies for FAT2 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for FAT2
    Search antibodies-online for antibodies for FAT2 

    FAT2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FAT2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FAT2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for FAT2 
    antibodies-online kits for FAT2 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CDHR: Cadherins / Cadherin-related

    Selected InterPro protein domains (see all 8):
     IPR000742 EG-like_dom
     IPR013320 ConA-like_subgrp
     IPR001791 Laminin_G
     IPR015919 Cadherin-like
     IPR020894 Cadherin_CS

    Graphical View of Domain Structure for InterPro Entry Q9NYQ8

    ProtoNet protein and cluster: Q9NYQ8

    3 Blocks protein domains:
    IPB001791 Laminin G
    IPB002126 Cadherin
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: FAT2_HUMAN, Q9NYQ8
    Similarity: Contains 32 cadherin domains
    Similarity: Contains 2 EGF-like domains
    Similarity: Contains 1 laminin G-like domain


    Find genes that share domains with FAT2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FAT2_HUMAN, Q9NYQ8
    Function: Plays a role in the migration of epidermal cells. May modulate the extracellular space surronding
    parallel fibers of cerebellar during development (By similarity)

         Genatlas biochemistry entry for FAT2:
    Drosophila FAT tumor suppressor,homolog 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with FAT2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for FAT2:
     Cell cycle / mitosis defect  Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Fat2):
     normal 

    Find genes that share phenotypes with FAT2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fat2tm1Anjm for FAT2

       genOway: Develop your customized and physiologically relevant rodent model for FAT2

    miRNA
    Products:
        
    miRTarBase miRNAs that target FAT2:
    hsa-mir-10a-5p (MIRT047514), hsa-mir-542-5p (MIRT039349), hsa-mir-548b-3p (MIRT040508), hsa-mir-183-5p (MIRT047135), hsa-mir-16-5p (MIRT051119), hsa-mir-421 (MIRT039359), hsa-mir-17-3p (MIRT050749)

    Block miRNA regulation of human, mouse, rat FAT2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAT2 (see all 39):
    hsa-miR-106a hsa-miR-449a hsa-miR-93 hsa-miR-526b* hsa-miR-34c-5p hsa-miR-20a hsa-miR-449b hsa-miR-1236
    SwitchGear 3'UTR luciferase reporter plasmidFAT2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FAT2
    Predesigned siRNA for gene silencing in human, mouse, rat FAT2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FAT2

    Clone
    Products:
         
    OriGene clones in human, mouse for FAT2 (see all 4)
    OriGene ORF clones in mouse, rat for FAT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAT2 (NM_001447)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAT2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAT2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FAT2
    Browse ESI BIO Cell Lines and PureStem Progenitors for FAT2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAT2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FAT2_HUMAN, Q9NYQ8: Cell membrane; Single-pass type I membrane protein (Potential). Cell junction. Nucleus.
    Note=Localized at adhesion zippers (early state of adherens junctions) of keratinocytes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    extracellular2
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane IEA--
    GO:0005913cell-cell adherens junction IDA17900869
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with FAT2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAT2
    Interactions:

        Search GeneGlobe Interaction Network for FAT2

    2 Interacting proteins for FAT2 (Q9NYQ83) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUNP054123I2D: score=2 
    GRID2O434243I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007156homophilic cell adhesion ISS--
    GO:0010631epithelial cell migration IMP17900869

    Find genes that share ontologies with FAT2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAT2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FAT2 gene: 
    NM_001447.2  

    Unigene Cluster for FAT2:

    FAT tumor suppressor homolog 2 (Drosophila)
    Hs.591255  [show with all ESTs]
    Unigene Representative Sequence: NM_001447
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000520200(uc003lud.4) ENST00000261800(uc003lue.4 uc010jhx.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FAT2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAT2 (see all 39):
    hsa-miR-106a hsa-miR-449a hsa-miR-93 hsa-miR-526b* hsa-miR-34c-5p hsa-miR-20a hsa-miR-449b hsa-miR-1236
    SwitchGear 3'UTR luciferase reporter plasmidFAT2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FAT2
    Predesigned siRNA for gene silencing in human, mouse, rat FAT2
    Clone
    Products:
         
    OriGene clones in human, mouse for FAT2 (see all 4)
    OriGene ORF clones in mouse, rat for FAT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAT2 (NM_001447)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAT2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAT2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FAT2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAT2
      QuantiTect SYBR Green Assays in human, mouse, rat FAT2
      QuantiFast Probe-based Assays in human, mouse, rat FAT2

    Additional mRNA sequence: 

    AB011535.1 AB160984.1 AB177851.1 AF231022.1 AK124555.1 AK308619.1 AL157443.1 BC039143.2 

    5 DOTS entries:

    DT.425984  DT.99936211  DT.40202785  DT.97822741  DT.40129158 

    Selected AceView cDNA sequences (see all 66):

    BE615770 T09131 BQ013141 F11863 BQ011446 NM_001447 F11554 BE744513 
    BM932267 Z39733 AF231022 AI363785 AA584048 AB160984 F05848 BE744214 
    BE616288 BG679245 BG679796 BM016978 T31313 AA889896 BM045026 BU607961 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FAT2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23
    SP1:                                                                                                                                                
    SP2:                                                                                                                    -                           


    ECgene alternative splicing isoforms for FAT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FAT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGAGAGGGAG
    FAT2 Expression
    About this image


    FAT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             Endochondral Facial Bones
     
     Neural Tube (Nervous System)
             Metencephalon
    FAT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAT2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591255

    UniProtKB/Swiss-Prot: FAT2_HUMAN, Q9NYQ8
    Tissue specificity: Expressed in epidermal keratinocytes, infant brain, cerebellum, and also in a variety of
    tumors, such as pancreatic cancer, diffuse type gastric cancer, ovarian cancer, esophageal cancer, skin squamous
    cell carcinoma, head and neck cancer. Not expressed in melanoma cell line A375 cells, normal epidermal
    melanocytes or normal dermal fibroblasts. Expressed in epidermal keratinocytes and squamous cell carcinoma (at
    protein level)

        Custom PCR Arrays for FAT2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FAT2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAT2
    QuantiTect SYBR Green Assays in human, mouse, rat FAT2
    QuantiFast Probe-based Assays in human, mouse, rat FAT2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for FAT2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fat21 , 5 FAT tumor suppressor homolog 2 (Drosophila)1, 5 82.32(n)1
    81.97(a)1
      11 (32.50 cM)5
    2458271  NM_001029988.21  NP_001025159.11 
     552506095 
    chicken
    (Gallus gallus)
    Aves FAT21 FAT tumor suppressor homolog 2 (Drosophila) 66.29(n)
    63.49(a)
      416266  XM_414584.4  XP_414584.4 
    lizard
    (Anolis carolinensis)
    Reptilia FAT26
    FAT atypical cadherin 2
    57(a)
    1 ↔ 1
    2(137800269-137843183)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fat21 FAT atypical cadherin 2 60.11(n)
    55.39(a)
      100488325  XM_002941676.2  XP_002941722.2 
    zebrafish
    (Danio rerio)
    Actinopterygii fat21 FAT tumor suppressor homolog 2 (Drosophila) 54.54(n)
    47.81(a)
      568468  XM_001920023.4  XP_001920058.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CadN3 axon target recognition cell adhesion
    receptor
    26(a)
    (best of 2)
        --


    ENSEMBL Gene Tree for FAT2 (if available)
    TreeFam Gene Tree for FAT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FAT2 gene
    DCHS12  DCHS22  CELSR32  CELSR12  PCDH152  FAT42  FAT32  FAT12  
    CELSR22  
    10 SIMAP similar genes for FAT2 using alignment to 4 protein entries:     FAT2_HUMAN (see all proteins):
    KIAA0811    FAT1    PCDH1    FAT3    ME5    PCDHGA6
    F9    SNED1    ME1    ME6

    Find genes that share paralogs with FAT2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FAT2 (see all 2011)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1447799561,2
    Cuntested1150925517(+) AAGACG/AAGATT 2 /S /L mis11Minor allele frequency- A:0.00NA 4458
    rs612901761,2
    C,F--150883158(+) CCTGGT/AGAAGT 1 -- ds50013Minor allele frequency- A:0.50NA WA 6
    rs737989151,2
    C,F--150883459(+) TTTCCA/CAATAG 1 -- ds50012Minor allele frequency- C:0.10WA 120
    rs1653461,2
    C,F,O,A,H--150883594(+) TGGAAC/GGGCCT 1 -- ds500113Minor allele frequency- G:0.35NA EA NS WA CSA 916
    rs1887253001,2
    --150883671(+) AGATAC/TTTTAT 1 -- ut310--------
    rs343756021,2
    C--150883680(+) TTGTT-/AAAAAA 1 -- ut310--------
    rs1160800031,2
    C--150883700(+) CAATGA/GAACTA 1 -- ut310--------
    rs1448872091,2
    C--150883771(+) CTCTCA/GCCCAC 1 -- ut310--------
    rs1413932191,2
    C--150883840(+) TGACT-/TCTG  
            
    TCTGT
    1 -- ut310--------
    rs1381899701,2
    --150883852(+) TCCAGA/GAACAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FAT2 (150883653 - 150948505 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FAT2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv527096CNV Loss19592680
    esv24295CNV Gain19812545
    nsv883033CNV Gain21882294

    Human Gene Mutation Database (HGMD): FAT2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAT2
    DNA2.0 Custom Variant and Variant Library Synthesis for FAT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604269    OMIM disorders: --

    1 disease for FAT2:    
    About MalaCards
    skin squamous cell carcinoma


    Find genes that share disorders with FAT2           About GenesLikeMe


    Export disorders for FAT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FAT2 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with FAT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of high-molecular-weight proteins with multiple EGF- like motifs by motif-trap screening. (PubMed id 9693030)1, 2, 3 Nakayama M.... Ohara O. (Genomics 1998)
    2. Human Fat2 is localized at immature adherens junctions in epidermal keratinocytes. (PubMed id 17900869)1, 2 Matsui S....Matsuyoshi N. (J. Dermatol. Sci. 2007)
    3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    4. Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. (PubMed id 10716726)1, 2 Wu Q. and Maniatis T. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    6. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PubMed id 19199708)1 Gonzalez-Begne M....Yates J.R. (J. Proteome Res. 2009)
    7. Knockdown of Fat2 by siRNA inhibits the migration of human squamous carcinoma cells. (PubMed id 18534823)2 Matsui S....Matsuyoshi N. (J. Dermatol. Sci. 2008)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    9. Comparative integromics on FAT1, FAT2, FAT3 and FAT4. (PubMed id 16865240)2 Katoh Y. and Katoh M. (Int. J. Mol. Med. 2006)
    10. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2196 HGNC: 3596 AceView: FAT2 Ensembl:ENSG00000086570 euGenes: HUgn2196
    ECgene: FAT2 H-InvDB: FAT2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0811

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FAT2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FAT2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FAT2 gene:
    Search GeneIP for patents involving FAT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FAT2  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FAT2  
     OriGene qSTAR qPCR primer pairs in human, mouse for FAT2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FAT2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FAT2   OriGene Custom Protein Services for FAT2  

     
     
     Block miRNA regulation of human, mouse, rat FAT2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FAT2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAT2 Predesigned siRNA for gene silencing in human, mouse, rat FAT2
     QuantiFast Probe-based Assays in human, mouse, rat FAT2 QuantiTect SYBR Green Assays in human, mouse, rat FAT2
     Custom PCR Arrays for FAT2 Search Chromatin IP Primers for FAT2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAT2  Search GeneGlobe Interaction Network for FAT2
     Regulatory tfbs in FAT2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for FAT2 GenScript cDNA clones with any tag delivered in your preferred vector for FAT2
     GenScript Custom Assay Services for FAT2 GenScript Custom overexpressing Cell Line Services for FAT2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FAT2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Biologicals
     Novus Tissue Slides
     Search for Antibodies for FAT2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for FAT2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for FAT2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAT2
     SwitchGear 3'UTR luciferase reporter plasmids for FAT2
     SwitchGear Promoter luciferase reporter plasmids for FAT2
     Search ThermoFisher Antibodies for FAT2
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAT2
     Browse compounds at ApexBio
     Search Addgene for plasmids for FAT2
      Search eBioscience for proteins for FAT2
      Search eBioscience for elisas for FAT2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for FAT2
      Search antibodies-online for antibodies for FAT2
     antibodies-online kits for FAT2 (6 products)
      Search antibodies-online for peptides for FAT2
      Search antibodies-online for proteins for FAT2
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FAT2 gene at Home site.
    Version: 3.12.248 16 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4