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Aliases for FAT2 Gene

Aliases for FAT2 Gene

  • FAT Atypical Cadherin 2 2 3
  • MEGF1 3 4 6
  • Multiple Epidermal Growth Factor-Like Domains Protein 1 3 4
  • Multiple EGF-Like Domains Protein 1 3 4
  • Cadherin-Related Family Member 9 2 3
  • Cadherin Family Member 8 3 4
  • HFAT2 3 4
  • CDHF8 3 4
  • Multiple Epidermal Growth Factor-Like Domains 1 3
  • FAT Tumor Suppressor (Drosophila) Homolog 2 2
  • FAT Tumor Suppressor Homolog 2 (Drosophila) 2
  • FAT Tumor Suppressor Homolog 2 3
  • Protocadherin Fat 2 3
  • Protocadherin FAT2 3
  • KIAA0811 4
  • CDHR9 3

External Ids for FAT2 Gene

Previous GeneCards Identifiers for FAT2 Gene

  • GC05M150952
  • GC05M151480
  • GC05M150912
  • GC05M150863
  • GC05M146029
  • GC05M150883

Summaries for FAT2 Gene

Entrez Gene Summary for FAT2 Gene

  • This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. [provided by RefSeq, Jul 2008]

GeneCards Summary for FAT2 Gene

FAT2 (FAT Atypical Cadherin 2) is a Protein Coding gene. Diseases associated with FAT2 include skin squamous cell carcinoma and squamous cell carcinoma, head and neck. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is FAT4.

UniProtKB/Swiss-Prot for FAT2 Gene

  • Plays a role in the migration of epidermal cells. May modulate the extracellular space surronding parallel fibers of cerebellar during development (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAT2 Gene

Genomics for FAT2 Gene

Regulatory Elements for FAT2 Gene

Genomic Location for FAT2 Gene

Start:
151,504,092 bp from pter
End:
151,591,335 bp from pter
Size:
87,244 bases
Orientation:
Minus strand

Genomic View for FAT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAT2 Gene

Proteins for FAT2 Gene

  • Protein details for FAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYQ8-FAT2_HUMAN
    Recommended name:
    Protocadherin Fat 2
    Protein Accession:
    Q9NYQ8
    Secondary Accessions:
    • O75091
    • Q9NSR7

    Protein attributes for FAT2 Gene

    Size:
    4349 amino acids
    Molecular mass:
    479317 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for FAT2 Gene

Proteomics data for FAT2 Gene at MOPED

Post-translational modifications for FAT2 Gene

  • Glycosylation at Asn39, Asn210, Asn280, Asn330, Asn459, Asn568, Asn627, Asn655, Asn789, Asn996, Asn1175, Asn1383, Asn1417, Asn1904, Asn1998, Asn2007, Asn2165, Asn2183, Asn2325, Asn2368, Asn2387, Asn2430, Asn2470, Asn2547, Asn2597, Asn2654, Asn3125, Asn3276, Asn3310, Asn3430, Asn3471, Asn3601, Asn3772, Asn3813, Asn3840, Asn3873, Asn3904, Asn3989, and Thr4036
  • Modification sites at PhosphoSitePlus

Other Protein References for FAT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAT2 Gene

Domains for FAT2 Gene

Gene Families for FAT2 Gene

HGNC:
  • CDHR :Cadherins / Cadherin-related

Suggested Antigen Peptide Sequences for FAT2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYQ8

UniProtKB/Swiss-Prot:

FAT2_HUMAN :
  • Q9NYQ8
Domain:
  • Contains 32 cadherin domains.
  • Contains 2 EGF-like domains.
  • Contains 1 laminin G-like domain.
genes like me logo Genes that share domains with FAT2: view

Function for FAT2 Gene

Molecular function for FAT2 Gene

GENATLAS Biochemistry:
Drosophila FAT tumor suppressor,homolog 2
UniProtKB/Swiss-Prot Function:
Plays a role in the migration of epidermal cells. May modulate the extracellular space surronding parallel fibers of cerebellar during development (By similarity).

Gene Ontology (GO) - Molecular Function for FAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FAT2: view

Phenotypes for FAT2 Gene

genes like me logo Genes that share phenotypes with FAT2: view

Animal Models for FAT2 Gene

MGI Knock Outs for FAT2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAT2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FAT2 Gene

Localization for FAT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAT2 Gene

Cell membrane; Single-pass type I membrane protein. Cell junction. Nucleus. Note=Localized at adhesion zippers (early state of adherens junctions) of keratinocytes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAT2 Gene COMPARTMENTS Subcellular localization image for FAT2 gene
Compartment Confidence
nucleus 5
plasma membrane 5
extracellular 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane IEA --
GO:0005913 cell-cell adherens junction IDA 17900869
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAT2: view

Pathways for FAT2 Gene

SuperPathways for FAT2 Gene

No Data Available

Interacting Proteins for FAT2 Gene

Gene Ontology (GO) - Biological Process for FAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISS --
GO:0010631 epithelial cell migration IMP 17900869
genes like me logo Genes that share ontologies with FAT2: view

No data available for Pathways by source for FAT2 Gene

Transcripts for FAT2 Gene

Unigene Clusters for FAT2 Gene

FAT tumor suppressor homolog 2 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAT2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAT2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23
SP1:
SP2: -

Relevant External Links for FAT2 Gene

GeneLoc Exon Structure for
FAT2
ECgene alternative splicing isoforms for
FAT2

Expression for FAT2 Gene

mRNA expression in normal human tissues for FAT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAT2 Gene

This gene is overexpressed in Brain - Cerebellum (17.9), Brain - Cerebellar Hemisphere (15.9), and Esophagus - Mucosa (4.8).

Protein differential expression in normal tissues for FAT2 Gene

This gene is overexpressed in Plasma (42.3) and Serum (25.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FAT2 Gene

SOURCE GeneReport for Unigene cluster for FAT2 Gene Hs.591255

mRNA Expression by UniProt/SwissProt for FAT2 Gene

Q9NYQ8-FAT2_HUMAN
Tissue specificity: Expressed in epidermal keratinocytes, infant brain, cerebellum, and also in a variety of tumors, such as pancreatic cancer, diffuse type gastric cancer, ovarian cancer, esophageal cancer, skin squamous cell carcinoma, head and neck cancer. Not expressed in melanoma cell line A375 cells, normal epidermal melanocytes or normal dermal fibroblasts. Expressed in epidermal keratinocytes and squamous cell carcinoma (at protein level).
genes like me logo Genes that share expressions with FAT2: view

Expression partners for FAT2 Gene

In Situ Assay Products

Orthologs for FAT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FAT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAT2 35
  • 87.41 (n)
  • 87.02 (a)
FAT2 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAT2 35
  • 88.27 (n)
  • 88.48 (a)
FAT2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fat2 35
  • 82.32 (n)
  • 81.97 (a)
Fat2 16
Fat2 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAT2 35
  • 99.37 (n)
  • 99.33 (a)
FAT2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fat2 35
  • 82.2 (n)
  • 81.83 (a)
oppossum
(Monodelphis domestica)
Mammalia FAT2 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAT2 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAT2 35
  • 66.29 (n)
  • 63.49 (a)
FAT2 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAT2 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fat2 35
  • 60.11 (n)
  • 55.39 (a)
zebrafish
(Danio rerio)
Actinopterygii fat2 35
  • 54.54 (n)
  • 47.81 (a)
fat2 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CadN 37
  • 26 (a)
ft 37
  • 25 (a)
kug 36
  • 30 (a)
OneToMany
Species with no ortholog for FAT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAT2 Gene

ENSEMBL:
Gene Tree for FAT2 (if available)
TreeFam:
Gene Tree for FAT2 (if available)

Paralogs for FAT2 Gene

Paralogs for FAT2 Gene

Selected SIMAP similar genes for FAT2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FAT2: view

Variants for FAT2 Gene

Sequence variations from dbSNP and Humsavar for FAT2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs766206 -- 151,588,275(-) GGCCA(A/G)TTGGC intron-variant
rs998076 -- 151,545,208(-) GTCTA(C/T)TGGGC reference, synonymous-codon
rs1009091 -- 151,526,637(+) TGGCG(A/C)TATTC intron-variant
rs1036194 -- 151,591,146(+) TTCCC(A/C)TCCTC intron-variant
rs1110430 -- 151,537,095(-) GACTT(G/T)GGCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAT2 Gene

Variant ID Type Subtype PubMed ID
nsv883033 CNV Gain 21882294
nsv527096 CNV Loss 19592680
esv24295 CNV Gain 19812545

Relevant External Links for FAT2 Gene

HapMap Linkage Disequilibrium report
FAT2
Human Gene Mutation Database (HGMD)
FAT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAT2 Gene

Disorders for FAT2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for FAT2 Gene in MalaCards »

(2) Diseases for FAT2 Gene including...

genes like me logo Genes that share disorders with FAT2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FAT2 Gene

Publications for FAT2 Gene

  1. Identification of high-molecular-weight proteins with multiple EGF- like motifs by motif-trap screening. (PMID: 9693030) Nakayama M. … Ohara O. (Genomics 1998) 2 3 4
  2. Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. (PMID: 10716726) Wu Q. … Maniatis T. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4
  4. Human Fat2 is localized at immature adherens junctions in epidermal keratinocytes. (PMID: 17900869) Matsui S. … Matsuyoshi N. (J. Dermatol. Sci. 2007) 3 4
  5. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PMID: 19199708) Gonzalez-Begne M. … Yates J.R. (J. Proteome Res. 2009) 3

Products for FAT2 Gene

Sources for FAT2 Gene

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