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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAT1 Gene

protein-coding   GIFtS: 54
GCID: GC04M187508

FAT tumor suppressor homolog 1 (Drosophila)

(Previous name: FAT tumor suppressor (Drosophila) homolog )
(Previous symbol: FAT)
 Explore 13 diseases affiliated with
FAT1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FAT1    

Aliases
for FAT1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
FAT Tumor Suppressor Homolog 1 (Drosophila)1 2     FAT Tumor Suppressor (Drosophila) Homolog1
FAT1 2 3 5     ME52
CDHF71 2 3     Cadherin ME52
CDHR81 2     Cadherin-Related Family Member 82
Cadherin Family Member 72 3     FAT Tumor Suppressor 12
Cadherin-Related Tumor Suppressor Homolog2 3     HFat11
Protein Fat Homolog2 3     Protocadherin Fat 12

External Ids:    HGNC: 35951   Entrez Gene: 21952   Ensembl: ENSG000000838577   OMIM: 6009765   UniProtKB: Q145173   

Export aliases for FAT1 gene to outside databases

Previous GC identifers: GC04M187746 GC04M183256


Summaries
for FAT1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FAT1:
This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell
proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of
integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem
cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G
domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an
adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell
communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they
have not been fully described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FAT1_HUMAN, Q14517
Function: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact
(By similarity)

Gene Wiki entry for FAT1 (FAT)


Genomic Views
for FAT1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAT1 gene promoter:
         Nkx3-1 v2   Nkx3-1   PPAR-gamma1   Nkx3-1 v3   Nkx3-1 v1   PPAR-gamma2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): FAT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FAT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35   Ensembl cytogenetic band:  4q35.2   HGNC cytogenetic band: 4q35.2

FAT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAT1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M187508:  view genomic region     (about GC identifiers)

Start:
 187,508,937 bp from pter      End:
 187,647,876 bp from pter
Size:
 138,940 bases      Orientation:
 minus strand

Proteins
for FAT1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FAT1_HUMAN, Q14517 (See protein sequence)
Recommended Name: Protocadherin Fat 1 precursor  
Size: 4588 amino acids; 506273 Da
Subunit: Interacts (via the C-terminus 4300-4400 AA) with ATN1. Interacts with RERE. Interacts (via EVH1 domains) with
ENAH (By similarity). Interacts (via cytoplasmic domain) with CTNNB1 (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, perinuclear region

Explore the universe of human proteins at neXtProt for FAT1: NX_Q14517

Post-translational modifications:

  • Undergoes proteolytic cleavage. The extracellular domain is cleaved off and the cytoplasmic domain (about 400 AA)
    • shuttles to the nucleus1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14517

    • FAT1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005236.2  
    ENSEMBL proteins: 
     ENSP00000406229   ENSP00000424157   ENSP00000423801   ENSP00000421003   ENSP00000420869  
     ENSP00000423736  

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    Uscn Proteins for FAT1

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15922730
    GO:0005886plasma membrane IDA15922730
    GO:0005887integral to plasma membrane TAS8586420
    GO:0005911cell-cell junction IDA15148305
    GO:0016021integral to membrane ----


    FAT1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for FAT1

    Protein Domains /
    Families
    for FAT1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FAT1 for domains           About GeneDecksing

    5/11 InterPro domains/families (see all 11):
     IPR000742 EG-like_dom
     IPR013320 ConA-like_subgrp
     IPR001791 Laminin_G
     IPR015919 Cadherin-like
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site

    Graphical View of Domain Structure for InterPro Entry Q14517

    ProtoNet protein and cluster: Q14517

    5 Blocks protein families:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB001791 Laminin G
    IPB001881 EGF-like calcium-binding
    IPB002126 Cadherin
    IPB003129 Thrombospondin


    UniProtKB/Swiss-Prot: FAT1_HUMAN, Q14517
    Domain: A PTB-like motif (DNXYH sequence) is required for the targeting to the leading edge. This motif represents a
    minimal protein-protein interaction core motif that is not regulated by tyrosine phosphorylation (By similarity)
    Similarity: Contains 33 cadherin domains
    Similarity: Contains 5 EGF-like domains
    Similarity: Contains 1 laminin G-like domain


    Function
    for FAT1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FAT1_HUMAN, Q14517
    Function: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact
    (By similarity)

         Genatlas biochemistry entry for FAT1:
    Drosophila tumor suppressor fat homolog,expressed in many epithelial and some endothelial cells,putative adhesion
    molecule,cadherin superfamilily

    miRNA
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    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate FAT1 (see all 22):
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    SwitchGear 3'UTR luciferase reporter plasmid: FAT1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI19131340


    FAT1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for FAT1:
     Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory 

    Animal Models:
         7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Fat1):
     craniofacial  integument  mortality/aging  nervous system  pigmentation 
     renal/urinary system  vision/eye 

    FAT1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FAT1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/14 Interacting proteins for FAT1 (Q145172, 3 ENSP000004062294) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENAHQ8N8S72, 3, ENSP000003558094MINT-3370478 MINT-3370511 I2D: score=2 STRING: ENSP00000355809
    HOMER1Q86YM72, 3, ENSP000003343824MINT-3370381 I2D: score=2 STRING: ENSP00000334382
    HOMER3Q9NSC52, 3, ENSP000003481504MINT-3370401 MINT-3370454 MINT-3370427 MINT-3370268 I2D: score=2 STRING: ENSP00000348150
    HDAC6Q9UBN73, ENSP000003340614I2D: score=1 STRING: ENSP00000334061
    MPIP349493I2D: score=5 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007015actin filament organization ISS--
    GO:0007155cell adhesion TAS8586420
    GO:0007156homophilic cell adhesion IEA--
    GO:0007163establishment or maintenance of cell polarity ISS--
    GO:0007267cell-cell signaling TAS8586420


    FAT1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FAT1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAT1
    Search CenterWatch for drugs/clinical trials and news about FAT1 

    Transcripts
    for FAT1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FAT1 gene: 
    NM_005245.3  

    Unigene Cluster for FAT1:

    FAT tumor suppressor homolog 1 (Drosophila)
    Hs.481371  [show with all ESTs]
    Unigene Representative Sequence: NM_005245
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000441802(uc010isn.3 uc003izf.3 uc010iso.1) ENST00000500085
    ENST00000512772 ENST00000507105 ENST00000509537 ENST00000509927 ENST00000507662
    ENST00000512347 ENST00000503253 ENST00000508035 ENST00000509647

    miRNA
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    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate FAT1 (see all 22):
    hsa-miR-892b hsa-miR-218-1* hsa-miR-223 hsa-miR-548a-3p hsa-miR-548g hsa-miR-641 hsa-miR-548x hsa-miR-548am
    SwitchGear 3'UTR luciferase reporter plasmid: FAT1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: FAT1
    OriGene siRNA: FAT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAT1
    Clone
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    Primer
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    Additional cDNA sequence: 

    AK307938.1 BC012432.1 D88798.1 EF139845.1 X87241.1 

    16 DOTS entries:

    DT.317047  DT.97801132  DT.75107345  DT.100813734  DT.92444050  DT.102824623  DT.97786274  DT.100813735 
    DT.92444046  DT.100018351  DT.100740143  DT.40266667  DT.92444051  DT.121236013  DT.91745710  DT.92444045 

    24/293 AceView cDNA sequences (see all 293):

    BM766063 BI494532 AU130380 AI587563 CR598584 BX950987 BE078257 AA133594 
    BM723967 BM820969 AI288546 AI217914 R44363 BM818370 AW327245 BP363494 
    AA587916 BQ718467 BM698320 CA489183 BF337432 BF515335 BX103284 AI270518 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for FAT1 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20a · 20b ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21 ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b
    SP1:                                                      
    SP2:                                                      
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for FAT1

    Expression
    for FAT1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACACAGTTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FAT1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyPodocyte LayerPodocytesKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)

    See FAT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAT1

    SOURCE GeneReport for Unigene cluster: Hs.481371

    UniProtKB/Swiss-Prot: FAT1_HUMAN, Q14517
    Tissue specificity: Expressed in many epithelial and some endothelial and smooth muscle cells

        SABiosciences Expression via Pathway-Focused PCR Array including FAT1: 
              Tumor Metastasis in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for FAT1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FAT1 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FAT11 FAT tumor suppressor homolog 1 (Drosophila) 76.35(n)
    81.43(a)    		   395168  XM_420680.3  XP_420680.2 
    lizard
    (Anolis carolinensis)    		 Reptilia FAT16
    		 --
    		 78(a)
    		 1 ↔ 1
    		 5(111295551-111449118)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.90282 Xenopus laevis transcribed sequence with moderate similarity to protein refNP_005236.1 (H.sapiens) FAT tumor suppressor precursor; cadherin family member 7 precursor; homolog of Drosophila tumor suppressor Fat precursor; cadherin-related tumor suppresso less 73.97(n)    BX848070.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii fat11 FAT tumor suppressor homolog 1 64.68(n)
    64.82(a)    		   406172  NM_212967.1  NP_998132.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta kug1 kugelei 47.99(n)
    39.02(a)    		   40191  NM_140914.2  NP_649171.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea cdh-41 Protein CDH-4 44.19(n)
    30.89(a)    		   175590  NM_065516.2  NP_497917.1 


    ENSEMBL Gene Tree for FAT1 (if available)
    TreeFam Gene Tree for FAT1 (if available) 

    Paralogs
    for FAT1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAT1 gene
    CDH232  DCHS12  CDHR22  DCHS22  CELSR32  FAT22  CELSR12  CDHR12  
    PCDH152  FAT42  FAT32  CELSR22  
    12 SIMAP similar genes for FAT1 using alignment to 7 protein entries:     FAT1_HUMAN (see all proteins):
    ME5    F9    FAT2    FAT3    ME2    ME3
    ME6    NOTCH2NL    CDH23    DKFZp434P2350    FLJ00233    ME4

    FAT1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FAT1
    PGOHUM00000247443


    Genomic Variants
    for FAT1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 10 variations for FAT1
         10 CNVs: 80653 80655 80657 80656 92652 92654 92656 92655 92653 80654
    Human Gene Mutation Database (HGMD): FAT1
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAT1
    DNA2.0 Custom Variant and Variant Library Synthesis for FAT1

    Disorders / Diseases
    for FAT1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FAT1 for disorders           About GeneDecksing

    OMIM gene information: 600976    OMIM disorders: --

    13 diseases for FAT1:    About MalaCards
    steroid-resistant nephrotic syndrome    coronary artery vasospasm    dentin caries    bipolar affective disorder
    oral squamous cell carcinoma    squamous cell carcinoma    nephrotic syndrome    bipolar disorder
    breast cancer    oral cancer    obesity    carcinoma
    melanoma

    1 disease from the University of Copenhagen DISEASES database for FAT1:
    Dentin caries

    2 Novoseek disease relationships for FAT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 3.12 3 16581652 (2), 16865240 (1)
    tumors 0 1 15922730 (1)

    Human Genome Epidemiology (HuGE) Navigator: FAT1 (3 documents)

    Export disorders for FAT1 gene to outside databases

    Publications
    for FAT1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAT1 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with FAT1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule. (PubMed id 8586420)1, 2, 3, 9 Dunne J.... Owen M.J. (1995)
    2. Processing of the human protocadherin Fat1 and translocation of its cytoplasmic domain to the nucleus. (PubMed id 15922730)1, 2, 9 Magg T....Hofer H.W. (2005)
    3. Atrophin proteins interact with the Fat1 cadherin and regulate migration and orientation in vascular smooth muscle cells. (PubMed id 19131340)1, 2 Hou R. and Sibinga N.E. (2009)
    4. Differentially spliced isoforms of FAT1 are asymmetrically distributed within migrating cells. (PubMed id 17500054)1, 9 Braun G.S....Moeller M.J. (2007)
    5. The intracellular domain of the human protocadherin hFat1 interacts with Homer signalling scaffolding proteins. (PubMed id 16979624)1, 9 Schreiner D....Hofer H.W. (2006)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia. (PubMed id 22116550)1 de Bock C.E....Thorne R.F. (2012)
    8. The inherited blindness protein AIPL1 regulates the ub iquitin-like FAT10 pathway. (PubMed id 22347407)1 Bett J.S....van der Spuy J. (2012)
    9. Expression and function of the atypical cadherin FAT1 in chronic liver disease. (PubMed id 22959770)1 Valletta D....Hellerbrand C. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for FAT1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing FAT1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2195 HGNC: 3595 AceView: FAT Ensembl:ENSG00000083857 euGenes: HUgn2195
    ECgene: FAT1 H-InvDB: FAT1

    Other Databases showing FAT1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FAT1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAT1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FAT1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FAT1 gene:
    Search GeneIP for patents involving FAT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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