Aliases for FAT1 Gene
External Ids for FAT1 Gene
Previous HGNC Symbols for FAT1 Gene
Previous GeneCards Identifiers for FAT1 Gene
This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008]
GeneCards Summary for FAT1 Gene
FAT1 (FAT Atypical Cadherin 1) is a Protein Coding gene. Diseases associated with FAT1 include Dentin Caries and Precursor B-Cell Acute Lymphoblastic Leukemia. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is FAT4.
UniProtKB/Swiss-Prot for FAT1 Gene
Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact.