Aliases for FAT1 Gene
External Ids for FAT1 Gene
Previous Symbols for FAT1 Gene
This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008]
GeneCards Summary for FAT1 Gene
FAT1 (FAT Atypical Cadherin 1) is a Protein Coding gene. Diseases associated with FAT1 include dentin caries and precursor b-cell acute lymphoblastic leukemia. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is FAT4.
UniProtKB/Swiss-Prot for FAT1 Gene
Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact.