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FASTKD5 Gene

protein-coding   GIFtS: 43
GCID: GC20M003127

FAST Kinase Domains 5

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FAST Kinase Domains 51 2
dJ1187M17.52
FAST Kinase Domain-Containing Protein 52
KIAA17923

External Ids:    HGNC: 257901   Entrez Gene: 604932   Ensembl: ENSG000002152517   OMIM: 6142725   UniProtKB: Q7L8L63   

Export aliases for FASTKD5 gene to outside databases

Previous GC identifer: GC20M003077


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FASTKD5 Gene:
FASTKD5 (FAST kinase domains 5) is a protein-coding gene. Diseases associated with FASTKD5 include schizophrenia. GO annotations related to this gene include protein kinase activity.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the FASTKD5 gene promoter:
         Pax-2   Pax-2a   NF-kappaB   GATA-2   MZF-1   Ik-2   CP2   c-Myb   Zic3   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FASTKD5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FASTKD5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

FASTKD5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FASTKD5 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M003127:  view genomic region     (about GC identifiers)

Start:
3,127,165 bp from pter      End:
3,140,543 bp from pter
Size:
13,379 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FAKD5_HUMAN, Q7L8L6 (See protein sequence)
Recommended Name: FAST kinase domain-containing protein 5  
Size: 764 amino acids; 86574 Da
Sequence caution: Sequence=BAB15696.1; Type=Frameshift; Positions=662; Sequence=BAB47421.1; Type=Erroneous
initiation;
Secondary accessions: Q96JN3 Q9H5D1 Q9H8Y3

Explore the universe of human proteins at neXtProt for FASTKD5: NX_Q7L8L6

Explore proteomics data for FASTKD5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys87
  • Modification sites at PhosphoSitePlus

  • See FASTKD5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_068598.1  
    ENSEMBL proteins: 
     ENSP00000369618  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR010622 FAST_Leu-rich
     IPR013584 RAP
     IPR013579 FAST_2

    Graphical View of Domain Structure for InterPro Entry Q7L8L6

    ProtoNet protein and cluster: Q7L8L6

    UniProtKB/Swiss-Prot: FAKD5_HUMAN, Q7L8L6
    Similarity: Belongs to the FAST kinase family
    Similarity: Contains 1 RAP domain


    FASTKD5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    FASTKD5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FASTKD5:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 

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    hsa-miR-27a hsa-miR-3119 hsa-miR-27b
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--

    FASTKD5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FASTKD5
    Interactions:

        Search GeneGlobe Interaction Network for FASTKD5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for FASTKD5 (Q7L8L62, 3 ENSP000003696184) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MLH1P406922, 3, ENSP000002317904MINT-68316 I2D: score=1 STRING: ENSP00000231790
    CCDC85BQ158343, ENSP000003116954I2D: score=4 STRING: ENSP00000311695
    IRAK2O431873, ENSP000002564584I2D: score=1 STRING: ENSP00000256458
    UNC93B1Q9H1C43, ENSP000002274714I2D: score=1 STRING: ENSP00000227471
    NLRX1Q86UT63, ENSP000002921994I2D: score=1 STRING: ENSP00000292199
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045333cellular respiration ISS--

    FASTKD5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FASTKD5 (FAKD5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FASTKD5 gene: 
    NM_021826.4  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000380266(uc002whz.3)
    miRNA
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    hsa-miR-27a hsa-miR-3119 hsa-miR-27b
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      QuantiTect SYBR Green Assays in human, mouse, rat FASTKD5
      QuantiFast Probe-based Assays in human, mouse, rat FASTKD5

    Selected AceView cDNA sequences (see all 218):

    BE296416 AI470602 BM480008 BE044059 BQ063210 BM927457 BU507619 BM909470 
    BG481288 AI280555 BQ642543 BE252871 AI862396 AW134699 BM983023 BQ062115 
    CN484275 AI521183 AI768494 NM_021826 BE673075 BX492152 BC000515 BQ059605 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FASTKD5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FASTKD5 Expression
    About this image

    FASTKD5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FASTKD5 Protein Expression
        Custom PCR Arrays for FASTKD5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FASTKD5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FASTKD5 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fastkd51 , 5 FAST kinase domains 51, 5 81.03(n)1
    74.77(a)1
      2 (63.24 cM)5
    3806011  NM_001146084.11  NP_001139556.11 
     1306138405 
    chicken
    (Gallus gallus)
    Aves FASTKD51 FAST kinase domains 5 57.7(n)
    47.54(a)
      422937  XM_420875.4  XP_420875.3 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fastkd51 FAST kinase domains 5 55.28(n)
    49.66(a)
      100485386  XM_002936357.2  XP_002936403.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5699401 FAST kinase domain-containing protein 5-like 51.1(n)
    40.69(a)
      569940  XM_693356.6  XP_698448.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG21246
    --
    19(a)
    1 ↔ 1
    X(10490110-10493200)


    ENSEMBL Gene Tree for FASTKD5 (if available)
    TreeFam Gene Tree for FASTKD5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    3 SNPs for FASTKD5    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37467001,2,4
    ----see VAR_0538912 mis40--------
    rs37466991,2,4
    ----see VAR_0538932 mis40--------
    rs24228571,2,4
    ----see VAR_0538922 mis40--------

    HapMap Linkage Disequilibrium report for FASTKD5 (3127165 - 3140543 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for FASTKD5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912605CNV Loss21882294
    nsv912606CNV Loss21882294
    nsv912604CNV Loss21882294
    nsv833897CNV Loss17160897
    dgv4518n71CNV Loss21882294
    nsv524482CNV Gain19592680
    nsv833898CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614272    OMIM disorders: --

    1 disease for FASTKD5:    
    About MalaCards
    schizophrenia


    FASTKD5 for disorders           About GeneDecksing


    Export disorders for FASTKD5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FASTKD5 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with FASTKD5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2001)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    4. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    5. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    6. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    7. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S.... Dorf M.E. (Immunity 2011)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 60493 HGNC: 25790 AceView: UBCE7IP5 Ensembl:ENSG00000215251 euGenes: HUgn60493
    ECgene: FASTKD5 H-InvDB: FASTKD5

    (According to HUGE)
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    HUGE: KIAA1792

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FASTKD5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FASTKD5 gene:
    Search GeneIP for patents involving FASTKD5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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