Aliases for FASTKD5 Gene
Aliases for FASTKD5 Gene
External Ids for FASTKD5 Gene
- HGNC: 25790
- Entrez Gene: 60493
- Ensembl: ENSG00000215251
- OMIM: 614272
- UniProtKB: Q7L8L6
Previous GeneCards Identifiers for FASTKD5 Gene
- GC20M003077
Summaries for FASTKD5 Gene
GeneCards Summary for FASTKD5 Gene
FASTKD5 (FAST Kinase Domains 5) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and protein kinase activity.
UniProtKB/Swiss-Prot for FASTKD5 Gene
-
Plays an important role in the processing of non-canonical mitochondrial mRNA precursors (PubMed:25683715).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FASTKD5 Gene
Genomics for FASTKD5 Gene
Regulatory Elements for FASTKD5 Gene
Enhancers for FASTKD5 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH20G003113 | 0.5 | Ensembl | 12.2 | +46.7 | 46697 | 0.4 | ARID1B BHLHE40 ZNF394 EZH2 EGR2 | OXT UBOX5 FASTKD5 MRPS26 GNRH2 DDRGK1 ITPA UBOX5-AS1 GC20P003124 |
| GH20G003092 | 1.4 | FANTOM5 Ensembl ENCODE | 2.2 | +66.2 | 66237 | 2.5 | SUZ12 CEBPG RBBP5 THRB RARA SCRT2 ZNF207 ZNF600 EZH2 GATAD2A | SNRPB PCED1A UBOX5 FASTKD5 PTPRA RN7SL555P AVP |
| GH20G003156 | 1.2 | ENCODE | 0.7 | +1.4 | 1355 | 4.2 | MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 | UBOX5 ZNF343 VPS16 ITPA FASTKD5 GC20P003124 |
| GH20G003368 | 0.3 | FANTOM5 | 1.3 | -208.3 | -208290 | 0.3 | ITPA DDRGK1 GFRA4 UBOX5 FASTKD5 UBE2V1P1 GC20P003374 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FASTKD5 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FASTKD5 gene promoter:
Regulatory Element Products
Genomic Location for FASTKD5 Gene
- Chromosome:
- 20
- Start:
- 3,146,519 bp from pter
- End:
- 3,159,897 bp from pter
- Size:
- 13,379 bases
- Orientation:
- Minus strand
Genomic View for FASTKD5 Gene
Genes around FASTKD5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20p13 by Ensembl
- 20p13 by Entrez Gene
- 20p13 by HGNC
FASTKD5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FASTKD5 Gene
Proteins for FASTKD5 Gene
-
Protein details for FASTKD5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7L8L6-FAKD5_HUMAN
- Recommended name:
- FAST kinase domain-containing protein 5, mitochondrial
- Protein Accession:
- Q7L8L6
- Q96JN3
- Q9H5D1
- Q9H8Y3
Protein attributes for FASTKD5 Gene
- Size:
- 764 amino acids
- Molecular mass:
- 86574 Da
- Quaternary structure:
-
- Found in a complex with GRSF1, DDX28, DHX30 and FASTKD2. Associates with the 12S mitochondrial rRNA (12S mt-rRNA).
- SequenceCaution:
-
- Sequence=BAB15696.1; Type=Frameshift; Positions=662; Evidence={ECO:0000305}; Sequence=BAB47421.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for FASTKD5 Gene
Post-translational modifications for FASTKD5 Gene
Other Protein References for FASTKD5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FASTKD5
- Novus Biologicals Antibodies for FASTKD5
-
Abcam antibodies for FASTKD5
- Invitrogen Antibodies for FASTKD5
- GeneTex FASTKD5 antibody for FASTKD5
Protein Products
-
OriGene Purified Proteins for FASTKD5
- Search Origene for MassSpec and Protein Over-expression Lysates for FASTKD5
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- Search GeneTex for Proteins for FASTKD5
-
Abcam proteins for FASTKD5
Assay Products
No data available for DME Specific Peptides for FASTKD5 Gene
Domains & Families for FASTKD5 Gene
Protein Domains for FASTKD5 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FASTKD5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q7L8L6- Family:
-
- Belongs to the FAST kinase family.
No data available for Gene Families for FASTKD5 Gene
Function for FASTKD5 Gene
Molecular function for FASTKD5 Gene
- UniProtKB/Swiss-Prot Function:
- Plays an important role in the processing of non-canonical mitochondrial mRNA precursors (PubMed:25683715).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA,IDA | 22681889 |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0019843 | rRNA binding | IDA,IEA | 25683715 |
Phenotypes for FASTKD5 Gene
- MGI mutant phenotypes for FASTKD5:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for FASTKD5:
-
- Decreased hepcidin::fluc mRNA expression
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Downregulation of NF-kappaB pathway after LMP1 stimulation
- Decreased shRNA abundance
- Weakly decreased NFAT1-GFP nuclear translocation
- Downregulation of NF-kappaB pathway after TNFalpha stimulation
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FASTKD5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FASTKD5 gene
- Search ViGene Biosciences for FASTKD5
CRISPR Products
-
OriGene CRISPR knockouts for FASTKD5
-
Santa Cruz Biotechnology (SCBT) CRISPR for FASTKD5
- GenScript: Design CRISPR guide RNA sequences for FASTKD5
miRNA for FASTKD5 Gene
- miRTarBase miRNAs that target FASTKD5
miRNA Products
- Search ViGene Biosciences for FASTKD5
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FASTKD5
- Browse OriGene Inhibitory RNA Products For FASTKD5
-
ViGene Biosciences ready-to-package AAV shRNAs for FASTKD5 gene
Clone Products
-
OriGene ORF clones in human for FASTKD5
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- Addgene plasmids for FASTKD5
Cell Line Products
-
Horizon Cell Lines for FASTKD5
-
ViGene Biosciences adenoviral particle packaged cDNA for FASTKD5 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FASTKD5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FASTKD5 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FASTKD5 Gene
Localization for FASTKD5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FASTKD5 Gene
- Mitochondrion matrix, mitochondrion nucleoid. Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids. {ECO:0000269 PubMed:25683715}.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| cytosol | 2 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IDA,IEA | 20869947 |
| GO:0035770 | ribonucleoprotein granule | IDA | 25683715 |
| GO:0042645 | mitochondrial nucleoid | IEA,IDA | 25683715 |
Pathways & Interactions for FASTKD5 Gene
No Data Available
Interacting Proteins for FASTKD5 Gene
Selected Interacting proteins:
ENSP00000369618
Q7L8L6-FAKD5_HUMAN
for FASTKD5 Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000963 | mitochondrial RNA processing | IMP | 25683715 |
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0045333 | cellular respiration | ISS | 20869947 |
No data available for Pathways by source and SIGNOR curated interactions for FASTKD5 Gene
Transcripts for FASTKD5 Gene
mRNA/cDNA for FASTKD5 Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (218) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FASTKD5 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FASTKD5
-
Santa Cruz Biotechnology (SCBT) CRISPR for FASTKD5
- GenScript: Design CRISPR guide RNA sequences for FASTKD5
miRNA Products
- Search ViGene Biosciences for FASTKD5
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FASTKD5
- Browse OriGene Inhibitory RNA Products For FASTKD5
-
ViGene Biosciences ready-to-package AAV shRNAs for FASTKD5 gene
Clone Products
-
OriGene ORF clones in human for FASTKD5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FASTKD5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for FASTKD5
Flow Cytometry Products
Expression for FASTKD5 Gene
mRNA differential expression in normal tissues according to GTEx for FASTKD5 Gene
This gene is overexpressed in Muscle - Skeletal (x4.5).
This gene is overexpressed in Lung (19.7), Peripheral blood mononuclear cells (19.0), and Bone (8.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FASTKD5 Gene
NURSA nuclear receptor signaling pathways regulating expression of FASTKD5 Gene:
FASTKD5SOURCE GeneReport for Unigene cluster for FASTKD5 Gene:
Hs.741168mRNA Expression by UniProt/SwissProt for FASTKD5 Gene:
Q7L8L6-FAKD5_HUMAN
Tissue specificity:
Expression detected in spleen, thymus, testis, ovary, colon, heart, smooth muscle, kidney, brain, lung, liver and white adipose tissue with highest expression in heart, smooth muscle, liver and thyroid.
Evidence on tissue expression from TISSUES for FASTKD5 Gene
- Nervous system(4.6)
- Muscle(4.3)
- Lung(4.2)
- Skin(4.2)
Primer Products
-
OriGene qPCR primer pairs for FASTKD5
-
OriGene qPCR primer pairs and template standards for FASTKD5
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FASTKD5 Gene
Orthologs for FASTKD5 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FASTKD5 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FASTKD5 34 |
|
||
| dog (Canis familiaris) |
Mammalia | FASTKD5 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fastkd5 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fastkd5 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FASTKD5 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FASTKD5 34 35 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fastkd5 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC569940 34 |
|
||
| FASTKD5 35 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG2124 35 |
|
OneToOne |
- Species where no ortholog for FASTKD5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FASTKD5 Gene
No data available for Paralogs for FASTKD5 Gene
Variants for FASTKD5 Gene
| SNP ID | Clin | Chr 20 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000350120 | -- | 3,160,480(+) | GTTAT(-/A)ATTAT | upstream-variant-2KB | |
| rs1000860442 | -- | 3,157,154(+) | GCTGA(C/G)AATCT | intron-variant | |
| rs1001033893 | -- | 3,151,271(+) | TGTCC(C/T)GGGGC | intron-variant, downstream-variant-500B | |
| rs1001063423 | -- | 3,151,548(+) | TTTGG(C/G)AAGCT | intron-variant | |
| rs1001065372 | -- | 3,150,670(+) | CTAAC(A/T)CTGCT | intron-variant, nc-transcript-variant |
Residual Variation Intolerance Score:
73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.89;
67.54% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FASTKD5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FASTKD5
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FASTKD5 Gene
Disorders for FASTKD5 Gene
Relevant External Links for FASTKD5
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FASTKD5
No disorders were found for FASTKD5 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FASTKD5 Gene
Publications for FASTKD5 Gene
- Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
- Mitochondrial RNA granules are centers for posttranscriptional RNA processing and ribosome biogenesis. (PMID: 25683715) Antonicka H. … Shoubridge E.A. (Cell Rep. 2015) 3 4 64
- Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. (PMID: 20869947) Simarro M. … Anderson P. (Biochem. Biophys. Res. Commun. 2010) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3 64
Products for FASTKD5 Gene
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- Custom Antibody ServicesOriGene Antibodies for FASTKD5
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- OriGene Purified Proteins for FASTKD5
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- OriGene qPCR primer pairs and template standards for FASTKD5
- OriGene qPCR primer pairs for FASTKD5
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- Novus Biologicals Antibodies for FASTKD5
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- Novus Biologicals
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- Abcam antibodies for FASTKD5
- Abcam proteins for FASTKD5
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- Addgene plasmids for FASTKD5
- GeneTex FASTKD5 antibody for FASTKD5
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- ViGene Biosciences adenoviral particle packaged cDNA for FASTKD5 gene
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- Horizon Cell Lines for FASTKD5
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- VectorBuilder custom plasmid, inducible vectors for FASTKD5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FASTKD5
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FASTKD5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
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- (122) diseasecard
- (123) NIH Rare Diseases
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- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer