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Aliases for FASTKD5 Gene

Aliases for FASTKD5 Gene

  • FAST Kinase Domains 5 2 3 5
  • FAST Kinase Domain-Containing Protein 5, Mitochondrial 3
  • FAST Kinase Domain-Containing Protein 5 3
  • DJ1187M17.5 3
  • KIAA1792 4

External Ids for FASTKD5 Gene

Previous GeneCards Identifiers for FASTKD5 Gene

  • GC20M003077

Summaries for FASTKD5 Gene

GeneCards Summary for FASTKD5 Gene

FASTKD5 (FAST Kinase Domains 5) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and protein kinase activity.

UniProtKB/Swiss-Prot for FASTKD5 Gene

  • Plays an important role in the processing of non-canonical mitochondrial mRNA precursors (PubMed:25683715).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FASTKD5 Gene

Genomics for FASTKD5 Gene

Regulatory Elements for FASTKD5 Gene

Enhancers for FASTKD5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F003113 0.5 Ensembl 12.2 +46.6 46597 0.6 ARID1B BHLHE40 EGR2 OXT FASTKD5 UBOX5 MRPS26 GNRH2 DDRGK1 ITPA UBOX5-AS1 GC20P003124
GH20F003092 1.3 FANTOM5 Ensembl ENCODE 2.2 +66.2 66237 2.5 CEBPG THRB RARA SCRT2 ZNF207 ZNF600 SCRT1 GATAD2A KLF6 HLF SNRPB PCED1A UBOX5 FASTKD5 PTPRA AVP RN7SL555P
GH20F003156 1.2 ENCODE 0.8 +1.4 1355 4.2 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 UBOX5 RN7SL555P ZNF343 VPS16 ITPA ENSG00000229539 UBOX5-AS1 FASTKD5 GC20P003124
GH20F003368 0.3 FANTOM5 1.3 -208.3 -208290 0.3 ITPA DDRGK1 GFRA4 FASTKD5 UBOX5 GC20P003374 UBE2V1P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FASTKD5 on UCSC Golden Path with GeneCards custom track

Promoters for FASTKD5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001446679 397 2600 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for FASTKD5 Gene

Chromosome:
20
Start:
3,146,519 bp from pter
End:
3,159,897 bp from pter
Size:
13,379 bases
Orientation:
Minus strand

Genomic View for FASTKD5 Gene

Genes around FASTKD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FASTKD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FASTKD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FASTKD5 Gene

Proteins for FASTKD5 Gene

  • Protein details for FASTKD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L8L6-FAKD5_HUMAN
    Recommended name:
    FAST kinase domain-containing protein 5, mitochondrial
    Protein Accession:
    Q7L8L6
    Secondary Accessions:
    • Q96JN3
    • Q9H5D1
    • Q9H8Y3

    Protein attributes for FASTKD5 Gene

    Size:
    764 amino acids
    Molecular mass:
    86574 Da
    Quaternary structure:
    • Found in a complex with GRSF1, DDX28, DHX30 and FASTKD2. Associates with the 12S mitochondrial rRNA (12S mt-rRNA).
    SequenceCaution:
    • Sequence=BAB15696.1; Type=Frameshift; Positions=662; Evidence={ECO:0000305}; Sequence=BAB47421.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for FASTKD5 Gene

Post-translational modifications for FASTKD5 Gene

  • Ubiquitination at Lys 87
  • Modification sites at PhosphoSitePlus

Other Protein References for FASTKD5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FASTKD5 Gene

Domains & Families for FASTKD5 Gene

Protein Domains for FASTKD5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FASTKD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L8L6

UniProtKB/Swiss-Prot:

FAKD5_HUMAN :
  • Contains 1 RAP domain.
  • Belongs to the FAST kinase family.
Domain:
  • Contains 1 RAP domain.
Family:
  • Belongs to the FAST kinase family.
genes like me logo Genes that share domains with FASTKD5: view

No data available for Gene Families for FASTKD5 Gene

Function for FASTKD5 Gene

Molecular function for FASTKD5 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the processing of non-canonical mitochondrial mRNA precursors (PubMed:25683715).

Gene Ontology (GO) - Molecular Function for FASTKD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0019843 rRNA binding IEA,IDA 25683715
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with FASTKD5: view
genes like me logo Genes that share phenotypes with FASTKD5: view

Animal Model Products

miRNA for FASTKD5 Gene

miRTarBase miRNAs that target FASTKD5

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FASTKD5 Gene

Localization for FASTKD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FASTKD5 Gene

Mitochondrion matrix, mitochondrion nucleoid. Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids. {ECO:0000269 PubMed:25683715}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FASTKD5 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for FASTKD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA 20869947
GO:0035770 ribonucleoprotein granule IDA 25683715
GO:0042645 mitochondrial nucleoid IEA,IDA 25683715
genes like me logo Genes that share ontologies with FASTKD5: view

Pathways & Interactions for FASTKD5 Gene

SuperPathways for FASTKD5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FASTKD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000963 mitochondrial RNA processing IMP 25683715
GO:0006397 mRNA processing IEA --
GO:0006468 protein phosphorylation IEA --
GO:0045333 cellular respiration ISS 20869947
genes like me logo Genes that share ontologies with FASTKD5: view

No data available for Pathways by source and SIGNOR curated interactions for FASTKD5 Gene

Transcripts for FASTKD5 Gene

mRNA/cDNA for FASTKD5 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(218) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FASTKD5 Gene

FAST kinase domains 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FASTKD5 Gene

No ASD Table

Relevant External Links for FASTKD5 Gene

GeneLoc Exon Structure for
FASTKD5
ECgene alternative splicing isoforms for
FASTKD5

Expression for FASTKD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FASTKD5 Gene

mRNA differential expression in normal tissues according to GTEx for FASTKD5 Gene

This gene is overexpressed in Muscle - Skeletal (x4.5).

Protein differential expression in normal tissues from HIPED for FASTKD5 Gene

This gene is overexpressed in Lung (19.7), Peripheral blood mononuclear cells (19.0), and Bone (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FASTKD5 Gene



Protein tissue co-expression partners for FASTKD5 Gene

NURSA nuclear receptor signaling pathways regulating expression of FASTKD5 Gene:

FASTKD5

SOURCE GeneReport for Unigene cluster for FASTKD5 Gene:

Hs.741168

mRNA Expression by UniProt/SwissProt for FASTKD5 Gene:

Q7L8L6-FAKD5_HUMAN
Tissue specificity: Expression detected in spleen, thymus, testis, ovary, colon, heart, smooth muscle, kidney, brain, lung, liver and white adipose tissue with highest expression in heart, smooth muscle, liver and thyroid.
genes like me logo Genes that share expression patterns with FASTKD5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FASTKD5 Gene

Orthologs for FASTKD5 Gene

This gene was present in the common ancestor of animals.

Orthologs for FASTKD5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FASTKD5 34 35
  • 99.3 (n)
cow
(Bos Taurus)
Mammalia FASTKD5 34
  • 86.16 (n)
dog
(Canis familiaris)
Mammalia FASTKD5 34 35
  • 84.28 (n)
rat
(Rattus norvegicus)
Mammalia Fastkd5 34
  • 81.78 (n)
mouse
(Mus musculus)
Mammalia Fastkd5 34 16 35
  • 81.03 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FASTKD5 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves FASTKD5 34 35
  • 57.7 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia fastkd5 34
  • 55.28 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC569940 34
  • 51.1 (n)
FASTKD5 35
  • 35 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2124 35
  • 19 (a)
OneToOne
Species where no ortholog for FASTKD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FASTKD5 Gene

ENSEMBL:
Gene Tree for FASTKD5 (if available)
TreeFam:
Gene Tree for FASTKD5 (if available)

Paralogs for FASTKD5 Gene

No data available for Paralogs for FASTKD5 Gene

Variants for FASTKD5 Gene

Sequence variations from dbSNP and Humsavar for FASTKD5 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs111501396 -- 3,158,520(+) CCAGG(A/C)TGGAG intron-variant
rs111616310 -- 3,159,380(+) CACCC(-/CA)GTCCT intron-variant
rs112169763 -- 3,158,759(+) GTGAG(A/C)CACTG intron-variant
rs112443373 -- 3,150,267(+) AGAAG(G/T)TTGAG intron-variant
rs112812306 -- 3,152,325(+) AAATA(C/T)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FASTKD5 Gene

Variant ID Type Subtype PubMed ID
nsv524482 CNV gain 19592680
nsv585276 CNV gain 21841781
nsv833897 CNV loss 17160897
nsv833898 CNV gain+loss 17160897

Variation tolerance for FASTKD5 Gene

Residual Variation Intolerance Score: 73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.89; 67.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FASTKD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FASTKD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FASTKD5 Gene

Disorders for FASTKD5 Gene

Relevant External Links for FASTKD5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FASTKD5

No disorders were found for FASTKD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FASTKD5 Gene

Publications for FASTKD5 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  2. Mitochondrial RNA granules are centers for posttranscriptional RNA processing and ribosome biogenesis. (PMID: 25683715) Antonicka H. … Shoubridge E.A. (Cell Rep. 2015) 3 4 64
  3. Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. (PMID: 20869947) Simarro M. … Anderson P. (Biochem. Biophys. Res. Commun. 2010) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64

Products for FASTKD5 Gene

Sources for FASTKD5 Gene

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