Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FASTKD3 Gene

Aliases for FASTKD3 Gene

  • FAST Kinase Domains 3 2 3 5

External Ids for FASTKD3 Gene

Summaries for FASTKD3 Gene

Entrez Gene Summary for FASTKD3 Gene

  • This gene encodes a member of a small family of Fas-activated serine/threonine kinase domain (FASTKD) containing proteins that share an amino terminal mitochondrial targeting domain and multiple carboxy terminal FAST domains as well as a putative RNA-binding RAP domain. The members of this family are ubiquitously expressed and are generally most abundant in mitochondria-enriched tissues such as heart, skeletal muscle and brown-adipose tissue. Some members of this protein family may play a role in apoptosis. The protein encoded by this gene interacts with components of the mitochondrial respiratory and translation networks. A pseudogene of this gene is also present on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

GeneCards Summary for FASTKD3 Gene

FASTKD3 (FAST Kinase Domains 3) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and protein kinase activity. An important paralog of this gene is TBRG4.

UniProtKB/Swiss-Prot for FASTKD3 Gene

  • Required for normal mitochondrial respiration.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FASTKD3 Gene

Genomics for FASTKD3 Gene

Regulatory Elements for FASTKD3 Gene

Enhancers for FASTKD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F007867 0.4 ENCODE 7 -0.3 -276 3.4 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS DEK MTRR MIR4458 FASTKD3 ENSG00000251168
GH05F007871 0.4 ENCODE 0.8 -2.9 -2880 1.1 SCRT1 GFI1B SCRT2 NR2F6 PRDM10 KDM1A TBX21 C5orf49 MTRR FASTKD3 ENSG00000251168
GH05F007877 1 FANTOM5 Ensembl ENCODE 0.4 -10.0 -9986 2.1 ELF3 ARID4B BMI1 RARA CBX5 FOS CREM MIXL1 CBFB CEBPB MTRR MIR4458HG FASTKD3 ENSG00000251168
GH05F007881 0.7 FANTOM5 0.4 -13.1 -13085 0.4 MTRR FASTKD3 ENSG00000251168
GH05F007852 0.2 ENCODE 0.3 +17.1 17115 0.2 GATAD2A PKNOX1 ZNF687 HCFC1 FOXA3 MNT DPF2 RAD21 YY1 ZNF335 GC05P007853 PIR49430 FASTKD3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FASTKD3 on UCSC Golden Path with GeneCards custom track

Genomic Location for FASTKD3 Gene

Chromosome:
5
Start:
7,859,159 bp from pter
End:
7,869,037 bp from pter
Size:
9,879 bases
Orientation:
Minus strand

Genomic View for FASTKD3 Gene

Genes around FASTKD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FASTKD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FASTKD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FASTKD3 Gene

Proteins for FASTKD3 Gene

  • Protein details for FASTKD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14CZ7-FAKD3_HUMAN
    Recommended name:
    FAST kinase domain-containing protein 3, mitochondrial
    Protein Accession:
    Q14CZ7
    Secondary Accessions:
    • Q9BVD3

    Protein attributes for FASTKD3 Gene

    Size:
    662 amino acids
    Molecular mass:
    75689 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FASTKD3 Gene

Post-translational modifications for FASTKD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FASTKD3 Gene

No data available for DME Specific Peptides for FASTKD3 Gene

Domains & Families for FASTKD3 Gene

Protein Domains for FASTKD3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FASTKD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14CZ7

UniProtKB/Swiss-Prot:

FAKD3_HUMAN :
  • Contains 1 RAP domain.
  • Belongs to the FAST kinase family.
Domain:
  • Contains 1 RAP domain.
Family:
  • Belongs to the FAST kinase family.
genes like me logo Genes that share domains with FASTKD3: view

No data available for Gene Families for FASTKD3 Gene

Function for FASTKD3 Gene

Molecular function for FASTKD3 Gene

UniProtKB/Swiss-Prot Function:
Required for normal mitochondrial respiration.

Gene Ontology (GO) - Molecular Function for FASTKD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with FASTKD3: view
genes like me logo Genes that share phenotypes with FASTKD3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FASTKD3 Gene

Localization for FASTKD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FASTKD3 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FASTKD3 Gene COMPARTMENTS Subcellular localization image for FASTKD3 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FASTKD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA 20869947
genes like me logo Genes that share ontologies with FASTKD3: view

Pathways & Interactions for FASTKD3 Gene

SuperPathways for FASTKD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FASTKD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0045333 cellular respiration IMP 20869947
genes like me logo Genes that share ontologies with FASTKD3: view

No data available for Pathways by source and SIGNOR curated interactions for FASTKD3 Gene

Drugs & Compounds for FASTKD3 Gene

(1) Drugs for FASTKD3 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR 1518
genes like me logo Genes that share compounds with FASTKD3: view

Transcripts for FASTKD3 Gene

Unigene Clusters for FASTKD3 Gene

FAST kinase domains 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FASTKD3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - -
SP4:
SP5: - -
SP6: -
SP7: -

Relevant External Links for FASTKD3 Gene

GeneLoc Exon Structure for
FASTKD3
ECgene alternative splicing isoforms for
FASTKD3

Expression for FASTKD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FASTKD3 Gene

Protein differential expression in normal tissues from HIPED for FASTKD3 Gene

This gene is overexpressed in Fetal gut (43.5) and Bone (25.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FASTKD3 Gene



Protein tissue co-expression partners for FASTKD3 Gene

NURSA nuclear receptor signaling pathways regulating expression of FASTKD3 Gene:

FASTKD3

SOURCE GeneReport for Unigene cluster for FASTKD3 Gene:

Hs.653162

mRNA Expression by UniProt/SwissProt for FASTKD3 Gene:

Q14CZ7-FAKD3_HUMAN
Tissue specificity: Expression detected in spleen, thymus, testis, ovary, colon, heart, smooth muscle, kidney, brain, lung, liver and white adipose tissue with highest expression in liver and thyroid.
genes like me logo Genes that share expression patterns with FASTKD3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FASTKD3 Gene

Orthologs for FASTKD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FASTKD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FASTKD3 34 35
  • 99.4 (n)
dog
(Canis familiaris)
Mammalia FASTKD3 34 35
  • 80.88 (n)
cow
(Bos Taurus)
Mammalia FASTKD3 34 35
  • 80.58 (n)
rat
(Rattus norvegicus)
Mammalia Fastkd3 34
  • 77.04 (n)
mouse
(Mus musculus)
Mammalia Fastkd3 34 16 35
  • 74.15 (n)
oppossum
(Monodelphis domestica)
Mammalia FASTKD3 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves FASTKD3 34 35
  • 62.76 (n)
lizard
(Anolis carolinensis)
Reptilia FASTKD3 35
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fastkd3 34
  • 58.78 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19038 34
zebrafish
(Danio rerio)
Actinopterygii fastkd3 34 35
  • 51.93 (n)
Species where no ortholog for FASTKD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FASTKD3 Gene

ENSEMBL:
Gene Tree for FASTKD3 (if available)
TreeFam:
Gene Tree for FASTKD3 (if available)

Paralogs for FASTKD3 Gene

Paralogs for FASTKD3 Gene

Pseudogenes.org Pseudogenes for FASTKD3 Gene

genes like me logo Genes that share paralogs with FASTKD3: view

Variants for FASTKD3 Gene

Sequence variations from dbSNP and Humsavar for FASTKD3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1801394 drug-response 7,870,860(+) GAAAT(A/G)TGTGA nc-transcript-variant, upstream-variant-2KB, reference, missense
VAR_036161 A breast cancer sample
rs72716536 Benign 7,869,122(+) GGTCC(C/T)GGGTA nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs10059339 -- 7,866,026(+) ATTGA(G/T)GTATG intron-variant
rs1046012 -- 7,859,410(-) AACAA(C/T)GGAAG intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FASTKD3 Gene

Variant ID Type Subtype PubMed ID
esv3304082 CNV mobile element insertion 20981092
esv3310380 CNV mobile element insertion 20981092
esv3420263 CNV insertion 20981092
esv3425786 CNV insertion 20981092
nsv597003 CNV gain 21841781
nsv597005 CNV gain 21841781

Variation tolerance for FASTKD3 Gene

Residual Variation Intolerance Score: 44.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.47; 64.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FASTKD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FASTKD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FASTKD3 Gene

Disorders for FASTKD3 Gene

Relevant External Links for FASTKD3

Genetic Association Database (GAD)
FASTKD3
Human Genome Epidemiology (HuGE) Navigator
FASTKD3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FASTKD3

No disorders were found for FASTKD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FASTKD3 Gene

Publications for FASTKD3 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  2. Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. (PMID: 20869947) Simarro M. … Anderson P. (Biochem. Biophys. Res. Commun. 2010) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for FASTKD3 Gene

Sources for FASTKD3 Gene

Content
Loading form....