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Aliases for FASTKD3 Gene

Aliases for FASTKD3 Gene

  • FAST Kinase Domains 3 2 3

External Ids for FASTKD3 Gene

Summaries for FASTKD3 Gene

Entrez Gene Summary for FASTKD3 Gene

  • This gene encodes a member of a small family of Fas-activated serine/threonine kinase domain (FASTKD) containing proteins that share an amino terminal mitochondrial targeting domain and multiple carboxy terminal FAST domains as well as a putative RNA-binding RAP domain. The members of this family are ubiquitously expressed and are generally most abundant in mitochondria-enriched tissues such as heart, skeletal muscle and brown-adipose tissue. Some members of this protein family may play a role in apoptosis. The protein encoded by this gene interacts with components of the mitochondrial respiratory and translation networks. A pseudogene of this gene is also present on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

GeneCards Summary for FASTKD3 Gene

FASTKD3 (FAST Kinase Domains 3) is a Protein Coding gene. GO annotations related to this gene include protein kinase activity. An important paralog of this gene is FASTKD1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FASTKD3 Gene

Genomics for FASTKD3 Gene

Regulatory Elements for FASTKD3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FASTKD3 Gene

Start:
7,859,159 bp from pter
End:
7,869,037 bp from pter
Size:
9,879 bases
Orientation:
Minus strand

Genomic View for FASTKD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FASTKD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FASTKD3 Gene

Proteins for FASTKD3 Gene

  • Protein details for FASTKD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14CZ7-FAKD3_HUMAN
    Recommended name:
    FAST kinase domain-containing protein 3
    Protein Accession:
    Q14CZ7
    Secondary Accessions:
    • Q9BVD3

    Protein attributes for FASTKD3 Gene

    Size:
    662 amino acids
    Molecular mass:
    75689 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FASTKD3 Gene

Proteomics data for FASTKD3 Gene at MOPED

Post-translational modifications for FASTKD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FASTKD3 Gene

No data available for DME Specific Peptides for FASTKD3 Gene

Domains for FASTKD3 Gene

Protein Domains for FASTKD3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FASTKD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14CZ7

UniProtKB/Swiss-Prot:

FAKD3_HUMAN :
  • Q14CZ7
Domain:
  • Contains 1 RAP domain.
Family:
  • Belongs to the FAST kinase family.
genes like me logo Genes that share domains with FASTKD3: view

No data available for Gene Families for FASTKD3 Gene

Function for FASTKD3 Gene

Gene Ontology (GO) - Molecular Function for FASTKD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with FASTKD3: view
genes like me logo Genes that share phenotypes with FASTKD3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FASTKD3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FASTKD3 Gene

Localization for FASTKD3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FASTKD3 Gene COMPARTMENTS Subcellular localization image for FASTKD3 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FASTKD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 20869947
genes like me logo Genes that share ontologies with FASTKD3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FASTKD3 Gene

Pathways for FASTKD3 Gene

SuperPathways for FASTKD3 Gene

No Data Available

Interacting Proteins for FASTKD3 Gene

Gene Ontology (GO) - Biological Process for FASTKD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0045333 cellular respiration IMP 20869947
genes like me logo Genes that share ontologies with FASTKD3: view

No data available for Pathways by source for FASTKD3 Gene

Transcripts for FASTKD3 Gene

Unigene Clusters for FASTKD3 Gene

FAST kinase domains 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FASTKD3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FASTKD3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FASTKD3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - -
SP4:
SP5: - -
SP6: -
SP7: -

Relevant External Links for FASTKD3 Gene

GeneLoc Exon Structure for
FASTKD3
ECgene alternative splicing isoforms for
FASTKD3

Expression for FASTKD3 Gene

mRNA expression in normal human tissues for FASTKD3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FASTKD3 Gene

SOURCE GeneReport for Unigene cluster for FASTKD3 Gene Hs.653162

genes like me logo Genes that share expressions with FASTKD3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FASTKD3 Gene

Orthologs for FASTKD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FASTKD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FASTKD3 35
  • 99.4 (n)
  • 99.09 (a)
FASTKD3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FASTKD3 35
  • 80.58 (n)
  • 74.96 (a)
FASTKD3 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FASTKD3 35
  • 80.88 (n)
  • 74.96 (a)
FASTKD3 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fastkd3 35
  • 74.15 (n)
  • 64.95 (a)
Fastkd3 16
Fastkd3 36
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FASTKD3 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fastkd3 35
  • 77.04 (n)
  • 69.17 (a)
chicken
(Gallus gallus)
Aves FASTKD3 35
  • 62.76 (n)
  • 53.33 (a)
FASTKD3 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FASTKD3 36
  • 48 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19038 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fastkd3 35
  • 58.78 (n)
  • 49.16 (a)
zebrafish
(Danio rerio)
Actinopterygii fastkd3 35
  • 51.93 (n)
  • 45.29 (a)
fastkd3 36
  • 44 (a)
OneToOne
Species with no ortholog for FASTKD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FASTKD3 Gene

ENSEMBL:
Gene Tree for FASTKD3 (if available)
TreeFam:
Gene Tree for FASTKD3 (if available)

Paralogs for FASTKD3 Gene

Paralogs for FASTKD3 Gene

Pseudogenes.org Pseudogenes for FASTKD3 Gene

genes like me logo Genes that share paralogs with FASTKD3: view

Variants for FASTKD3 Gene

Sequence variations from dbSNP and Humsavar for FASTKD3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs161875 -- 7,860,344(+) ATCTA(C/T)AGTGA intron-variant
rs162024 -- 7,860,291(+) GCAGC(G/T)CTCAT intron-variant
rs162026 -- 7,861,357(+) ATTTG(G/T)CTATT intron-variant
rs162027 -- 7,861,525(+) GATAC(C/T)GCTGC intron-variant
rs162028 -- 7,864,808(+) actat(A/T)aggga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FASTKD3 Gene

Variant ID Type Subtype PubMed ID
esv274651 CNV Insertion 20981092
esv268361 CNV Insertion 20981092

Relevant External Links for FASTKD3 Gene

HapMap Linkage Disequilibrium report
FASTKD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FASTKD3 Gene

Disorders for FASTKD3 Gene

(1) University of Copenhagen DISEASES for FASTKD3 Gene

Relevant External Links for FASTKD3

Genetic Association Database (GAD)
FASTKD3
Human Genome Epidemiology (HuGE) Navigator
FASTKD3
genes like me logo Genes that share disorders with FASTKD3: view

No data available for UniProtKB/Swiss-Prot for FASTKD3 Gene

Publications for FASTKD3 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3

Products for FASTKD3 Gene

Sources for FASTKD3 Gene

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