Aliases for FASTKD3 Gene
External Ids for FASTKD3 Gene
- HGNC: 28758
- Entrez Gene: 79072
- Ensembl: ENSG00000124279
- UniProtKB: Q14CZ7
Summaries for FASTKD3 Gene
-
This gene encodes a member of a small family of Fas-activated serine/threonine kinase domain (FASTKD) containing proteins that share an amino terminal mitochondrial targeting domain and multiple carboxy terminal FAST domains as well as a putative RNA-binding RAP domain. The members of this family are ubiquitously expressed and are generally most abundant in mitochondria-enriched tissues such as heart, skeletal muscle and brown-adipose tissue. Some members of this protein family may play a role in apoptosis. The protein encoded by this gene interacts with components of the mitochondrial respiratory and translation networks. A pseudogene of this gene is also present on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
GeneCards Summary for FASTKD3 Gene
FASTKD3 (FAST Kinase Domains 3) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and protein kinase activity. An important paralog of this gene is FASTKD1.
UniProtKB/Swiss-Prot for FASTKD3 Gene
-
Required for normal mitochondrial respiration.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FASTKD3 Gene
Genomics for FASTKD3 Gene
Regulatory Elements for FASTKD3 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH05G007867 | 1.1 | ENCODE | 6.9 | -0.3 | -276 | 3.4 | HNRNPUL1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143 | MTRR MIR4458HG FASTKD3 ENSG00000251168 |
| GH05G007877 | 1.5 | FANTOM5 Ensembl ENCODE | 0.4 | -10.0 | -9986 | 2.1 | HNRNPUL1 ARID4B CBX5 FOS ZHX2 JUNB TBX21 NFIL3 MBD2 NBN | MTRR MIR4458HG FASTKD3 ENSG00000251168 |
| GH05G007871 | 0.6 | ENCODE | 0.7 | -2.9 | -2880 | 1.1 | SCRT1 CTCF NR2F1 GFI1B TBX21 SCRT2 KDM1A PRDM10 NR2F6 | C5orf49 MTRR FASTKD3 ENSG00000251168 |
| GH05G007852 | 0.7 | ENCODE | 0.4 | +17.1 | 17115 | 0.2 | PKNOX1 FOXA2 SIN3A MAX RAD21 YY1 ZNF335 GATA3 GATAD2A ZNF687 | GC05P007853 PIR49430 FASTKD3 |
| GH05G007853 | 0.6 | ENCODE | 0.4 | +16.8 | 16832 | 0.3 | PKNOX1 ZNF687 SIN3A MNT DPF2 YY1 ZNF335 GATA3 JUND | GC05P007853 PIR49430 FASTKD3 |
- Transcription factor binding sites by QIAGEN in the FASTKD3 gene promoter:
Regulatory Element Products
Genomic Location for FASTKD3 Gene
- Chromosome:
- 5
- Start:
- 7,859,159 bp from pter
- End:
- 7,869,037 bp from pter
- Size:
- 9,879 bases
- Orientation:
- Minus strand
Genomic View for FASTKD3 Gene
- Cytogenetic band:
-
- 5p15.31 by Ensembl
- 5p15.31 by Entrez Gene
- 5p15.31 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FASTKD3 Gene
Proteins for FASTKD3 Gene
-
Protein details for FASTKD3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14CZ7-FAKD3_HUMAN
- Recommended name:
- FAST kinase domain-containing protein 3, mitochondrial
- Protein Accession:
- Q14CZ7
- Q9BVD3
Protein attributes for FASTKD3 Gene
- Size:
- 662 amino acids
- Molecular mass:
- 75689 Da
- Quaternary structure:
- No Data Available
Protein Expression for FASTKD3 Gene
Post-translational modifications for FASTKD3 Gene
Other Protein References for FASTKD3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FASTKD3
- Invitrogen Antibodies for FASTKD3
- antibodies-online Antibodies for FASTKD3: See all 29
- GeneTex FASTKD3 antibody for FASTKD3
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for FASTKD3
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- Novus Biologicals proteins for FASTKD3
- Search GeneTex for Proteins for FASTKD3
Assay Products
No data available for DME Specific Peptides for FASTKD3 Gene
Domains & Families for FASTKD3 Gene
Protein Domains for FASTKD3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FASTKD3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q14CZ7- Family:
-
- Belongs to the FAST kinase family.
No data available for Gene Families for FASTKD3 Gene
Function for FASTKD3 Gene
Molecular function for FASTKD3 Gene
- UniProtKB/Swiss-Prot Function:
- Required for normal mitochondrial respiration.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IDA | 22658674 |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for FASTKD3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FASTKD3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FASTKD3 gene
- Search ViGene Biosciences for FASTKD3
CRISPR Products
-
OriGene CRISPR knockouts for FASTKD3
-
Santa Cruz Biotechnology (SCBT) CRISPR for FASTKD3
- GenScript: Design CRISPR guide RNA sequences for FASTKD3
miRNA Products
- Search ViGene Biosciences for FASTKD3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FASTKD3
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-
ViGene Biosciences ready-to-package AAV shRNAs for FASTKD3 gene
Clone Products
-
OriGene ORF clones in human for FASTKD3
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Cell Line Products
-
Horizon Cell Lines for FASTKD3
-
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-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FASTKD3 Gene
Localization for FASTKD3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FASTKD3 Gene
- Mitochondrion.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
| GO:0005739 | mitochondrion | IDA | 20869947 |
Pathways & Interactions for FASTKD3 Gene
Interacting Proteins for FASTKD3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0045333 | cellular respiration | IMP | 20869947 |
No data available for Pathways by source and SIGNOR curated interactions for FASTKD3 Gene
Drugs & Compounds for FASTKD3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Methotrexate | Approved | Pharma | Folate antagonist,inhibits DFHR | 1551 |
Transcripts for FASTKD3 Gene
mRNA/cDNA for FASTKD3 Gene
- (2) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (61) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FASTKD3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FASTKD3
-
Santa Cruz Biotechnology (SCBT) CRISPR for FASTKD3
- GenScript: Design CRISPR guide RNA sequences for FASTKD3
miRNA Products
- Search ViGene Biosciences for FASTKD3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FASTKD3
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-
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Clone Products
-
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Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||
| SP7: | - |
Expression for FASTKD3 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FASTKD3 Gene
NURSA nuclear receptor signaling pathways regulating expression of FASTKD3 Gene:
FASTKD3SOURCE GeneReport for Unigene cluster for FASTKD3 Gene:
Hs.653162mRNA Expression by UniProt/SwissProt for FASTKD3 Gene:
Q14CZ7-FAKD3_HUMANEvidence on tissue expression from TISSUES for FASTKD3 Gene
- Nervous system(4.1)
Primer Products
-
OriGene qPCR primer pairs for FASTKD3
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FASTKD3 Gene
Orthologs for FASTKD3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FASTKD3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FASTKD3 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FASTKD3 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fastkd3 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fastkd3 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FASTKD3 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FASTKD3 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FASTKD3 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fastkd3 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.19038 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fastkd3 34 35 |
|
- Species where no ortholog for FASTKD3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FASTKD3 Gene
Variants for FASTKD3 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1801394 | drug-response | 7,870,860(+) | GAAAT(A/G)TGTGA | nc-transcript-variant, upstream-variant-2KB, reference, missense | |
| VAR_036161 | A breast cancer sample | ||||
| rs201383481 | Uncertain significance | 7,869,226(+) | CTGCC(G/T)GTCGG | intron-variant, upstream-variant-2KB | |
| rs368193742 | Uncertain significance | 7,869,229(+) | CCTGT(C/T)GGCTA | intron-variant, upstream-variant-2KB | |
| rs560321328 | Uncertain significance | 7,870,800(+) | ATGAG(A/C/G)AGGTT | nc-transcript-variant, upstream-variant-2KB, reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3304082 | CNV | mobile element insertion | 20981092 |
| esv3310380 | CNV | mobile element insertion | 20981092 |
| esv3420263 | CNV | insertion | 20981092 |
| esv3425786 | CNV | insertion | 20981092 |
| nsv597003 | CNV | gain | 21841781 |
| nsv597005 | CNV | gain | 21841781 |
Relevant External Links for FASTKD3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FASTKD3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FASTKD3 Gene
Disorders for FASTKD3 Gene
Relevant External Links for FASTKD3
No disorders were found for FASTKD3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FASTKD3 Gene
Publications for FASTKD3 Gene
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
- Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. (PMID: 20869947) Simarro M. … Anderson P. (Biochem. Biophys. Res. Commun. 2010) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
Products for FASTKD3 Gene
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- Novus Biologicals Antibodies for FASTKD3
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- Horizon Cell Lines for FASTKD3
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FASTKD3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
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- (122) diseasecard
- (123) NIH Rare Diseases
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- (128) Genetics Home Reference
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- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




