Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FASTKD2 Gene

Aliases for FASTKD2 Gene

  • FAST Kinase Domains 2 2 3
  • KIAA0971 2 3 4 6
  • FAST Kinase Domain-Containing Protein 2 3

External Ids for FASTKD2 Gene

Previous HGNC Symbols for FASTKD2 Gene

  • KIAA0971

Previous GeneCards Identifiers for FASTKD2 Gene

  • GC02P207338
  • GC02P207630
  • GC02P199479

Summaries for FASTKD2 Gene

Entrez Gene Summary for FASTKD2 Gene

  • This gene encodes a protein that is localized in the mitochondrial inner compartment and that may play a role in mitochondrial apoptosis. Nonsense mutations have been reported to result in cytochrome c oxidase deficiency. [provided by RefSeq, Oct 2008]

GeneCards Summary for FASTKD2 Gene

FASTKD2 (FAST Kinase Domains 2) is a Protein Coding gene. Diseases associated with FASTKD2 include fastkd2-related infantile mitochondrial encephalomyopathy and mitochondrial complex iv deficiency. GO annotations related to this gene include protein kinase activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FASTKD2 Gene

Genomics for FASTKD2 Gene

Regulatory Elements for FASTKD2 Gene

Genomic Location for FASTKD2 Gene

Start:
206,765,357 bp from pter
End:
206,796,189 bp from pter
Size:
30,833 bases
Orientation:
Plus strand

Genomic View for FASTKD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FASTKD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FASTKD2 Gene

Proteins for FASTKD2 Gene

  • Protein details for FASTKD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYY8-FAKD2_HUMAN
    Recommended name:
    FAST kinase domain-containing protein 2
    Protein Accession:
    Q9NYY8
    Secondary Accessions:
    • Q9NVX6
    • Q9Y2H7

    Protein attributes for FASTKD2 Gene

    Size:
    710 amino acids
    Molecular mass:
    81463 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA76815.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91617.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FASTKD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FASTKD2 Gene

Proteomics data for FASTKD2 Gene at MOPED

Post-translational modifications for FASTKD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FASTKD2 Gene

No data available for DME Specific Peptides for FASTKD2 Gene

Domains for FASTKD2 Gene

Protein Domains for FASTKD2 Gene

Suggested Antigen Peptide Sequences for FASTKD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYY8

UniProtKB/Swiss-Prot:

FAKD2_HUMAN :
  • Q9NYY8
Domain:
  • Contains 1 RAP domain.
Family:
  • Belongs to the FAST kinase family.
genes like me logo Genes that share domains with FASTKD2: view

No data available for Gene Families for FASTKD2 Gene

Function for FASTKD2 Gene

Gene Ontology (GO) - Molecular Function for FASTKD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with FASTKD2: view

Phenotypes for FASTKD2 Gene

GenomeRNAi human phenotypes for FASTKD2:
genes like me logo Genes that share phenotypes with FASTKD2: view

Animal Model Products

CRISPR Products

miRNA for FASTKD2 Gene

miRTarBase miRNAs that target FASTKD2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FASTKD2 Gene

Localization for FASTKD2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FASTKD2 Gene COMPARTMENTS Subcellular localization image for FASTKD2 gene
Compartment Confidence
mitochondrion 5
cytosol 2
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FASTKD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 20869947
genes like me logo Genes that share ontologies with FASTKD2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FASTKD2 Gene

Pathways for FASTKD2 Gene

SuperPathways for FASTKD2 Gene

No Data Available

Interacting Proteins for FASTKD2 Gene

Gene Ontology (GO) - Biological Process for FASTKD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0045333 cellular respiration ISS 20869947
genes like me logo Genes that share ontologies with FASTKD2: view

No data available for Pathways by source for FASTKD2 Gene

Transcripts for FASTKD2 Gene

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FASTKD2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FASTKD2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
SP1: - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - -
SP5: -
SP6:
SP7: -
SP8: - - -
SP9:

Relevant External Links for FASTKD2 Gene

GeneLoc Exon Structure for
FASTKD2
ECgene alternative splicing isoforms for
FASTKD2

Expression for FASTKD2 Gene

mRNA expression in normal human tissues for FASTKD2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FASTKD2 Gene

SOURCE GeneReport for Unigene cluster for FASTKD2 Gene Hs.5930

genes like me logo Genes that share expressions with FASTKD2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FASTKD2 Gene

Orthologs for FASTKD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FASTKD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FASTKD2 35
  • 99.71 (n)
  • 99.65 (a)
FASTKD2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FASTKD2 35
  • 81.4 (n)
  • 71.81 (a)
FASTKD2 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FASTKD2 35
  • 80.19 (n)
  • 70.06 (a)
FASTKD2 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fastkd2 35
  • 77.94 (n)
  • 66.76 (a)
Fastkd2 16
Fastkd2 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FASTKD2 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FASTKD2 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fastkd2 35
  • 77.23 (n)
  • 65.32 (a)
chicken
(Gallus gallus)
Aves FASTKD2 35
  • 58.24 (n)
  • 44.98 (a)
FASTKD2 36
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FASTKD2 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fastkd2 35
  • 52 (n)
  • 40.22 (a)
zebrafish
(Danio rerio)
Actinopterygii fastkd2 35
  • 51.93 (n)
  • 37.76 (a)
fastkd2 36
  • 32 (a)
OneToOne
Species with no ortholog for FASTKD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FASTKD2 Gene

ENSEMBL:
Gene Tree for FASTKD2 (if available)
TreeFam:
Gene Tree for FASTKD2 (if available)

Paralogs for FASTKD2 Gene

No data available for Paralogs for FASTKD2 Gene

Variants for FASTKD2 Gene

Sequence variations from dbSNP and Humsavar for FASTKD2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs725980 -- 206,773,856(+) AAGTT(C/G)AAGAT intron-variant
rs768533 -- 206,776,113(-) TTACA(C/T)ATTAT intron-variant
rs878832 -- 206,785,914(+) ACCAG(C/T)TATTC intron-variant
rs879472 -- 206,787,058(-) ACTAT(C/T)CTTTG intron-variant
rs1001805 -- 206,794,807(+) TTCCA(A/G)TTTAT utr-variant-3-prime

Relevant External Links for FASTKD2 Gene

HapMap Linkage Disequilibrium report
FASTKD2
Human Gene Mutation Database (HGMD)
FASTKD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FASTKD2 Gene

Disorders for FASTKD2 Gene

(1) OMIM Diseases for FASTKD2 Gene (612322)

(2) University of Copenhagen DISEASES for FASTKD2 Gene

Relevant External Links for FASTKD2

Genetic Association Database (GAD)
FASTKD2
Human Genome Epidemiology (HuGE) Navigator
FASTKD2
genes like me logo Genes that share disorders with FASTKD2: view

No data available for UniProtKB/Swiss-Prot for FASTKD2 Gene

Publications for FASTKD2 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  2. Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. (PMID: 20966902) Croteau-Chonka D.C. … Mohlke K.L. (Obesity (Silver Spring) 2011) 3 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for FASTKD2 Gene

Sources for FASTKD2 Gene

Back to Top

Content