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FASTKD2 Gene

protein-coding   GIFtS: 52
GCID: GC02P207630

FAST Kinase Domains 2

(Previous name: KIAA0971)
(Previous symbol: KIAA0971)
  See FASTKD2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FAST Kinase Domains 21 2
KIAA09711 2 3 5
FAST Kinase Domain-Containing Protein 22

External Ids:    HGNC: 291601   Entrez Gene: 228682   Ensembl: ENSG000001182467   OMIM: 6123225   UniProtKB: Q9NYY83   

Export aliases for FASTKD2 gene to outside databases

Previous GC identifers: GC02P207338 GC02P199479


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FASTKD2 Gene:
This gene encodes a protein that is localized in the mitochondrial inner compartment and that may play a role in
mitochondrial apoptosis. Nonsense mutations have been reported to result in cytochrome c oxidase deficiency.
(provided by RefSeq, Oct 2008)

GeneCards Summary for FASTKD2 Gene:
FASTKD2 (FAST kinase domains 2) is a protein-coding gene. Diseases associated with FASTKD2 include fastkd2-related infantile mitochondrial encephalomyopathy, and cytochrome-c oxidase deficiency disease. GO annotations related to this gene include protein kinase activity.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the FASTKD2 gene promoter:
         AREB6   POU2F1   HFH-1   POU2F1a   CUTL1   Cdc5   C/EBPalpha   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FASTKD2 promoter sequence
   Search Chromatin IP Primers for FASTKD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FASTKD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.3   Ensembl cytogenetic band:  2q33.3   HGNC cytogenetic band: 2q33.3

FASTKD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FASTKD2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P207630:  view genomic region     (about GC identifiers)

Start:
207,630,081 bp from pter      End:
207,660,913 bp from pter
Size:
30,833 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FAKD2_HUMAN, Q9NYY8 (See protein sequence)
Recommended Name: FAST kinase domain-containing protein 2  
Size: 710 amino acids; 81463 Da
Caution: It is uncertain whether Met-1 or Met-17 is the initiator
Sequence caution: Sequence=BAA76815.2; Type=Erroneous initiation; Sequence=BAA91617.1; Type=Erroneous initiation;
Secondary accessions: Q9NVX6 Q9Y2H7
Alternative splicing: 2 isoforms:  Q9NYY8-1   Q9NYY8-2   

Explore the universe of human proteins at neXtProt for FASTKD2: NX_Q9NYY8

Explore proteomics data for FASTKD2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FASTKD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001129665.1  NP_001129666.1  NP_055744.2  

    ENSEMBL proteins: 
     ENSP00000236980   ENSP00000409927   ENSP00000385990   ENSP00000384929  

    FASTKD2 Human Recombinant Protein Products:

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    Novus Biologicals FASTKD2 Protein
    Novus Biologicals FASTKD2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FASTKD2

     
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    LSBio Antibodies in human, mouse, rat for FASTKD2

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    Search eBioscience for ELISAs for FASTKD2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR010622 FAST_Leu-rich
     IPR013584 RAP
     IPR013579 FAST_2

    Graphical View of Domain Structure for InterPro Entry Q9NYY8

    ProtoNet protein and cluster: Q9NYY8

    2 Blocks protein domains:
    IPB013579 FAST kinase-like protein
    IPB013584 RAP domain


    UniProtKB/Swiss-Prot: FAKD2_HUMAN, Q9NYY8
    Similarity: Belongs to the FAST kinase family
    Similarity: Contains 1 RAP domain


    Find genes that share domains with FASTKD2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with FASTKD2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FASTKD2:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FASTKD2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FASTKD2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FASTKD2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FASTKD2

    miRNA
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    miRTarBase miRNAs that target FASTKD2:
    hsa-mir-16-5p (MIRT031546)

    Block miRNA regulation of human, mouse, rat FASTKD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FASTKD2 (see all 19):
    hsa-miR-549 hsa-miR-520d-5p hsa-miR-548s hsa-miR-583 hsa-miR-1323 hsa-miR-3613-3p hsa-miR-186 hsa-miR-3915
    SwitchGear 3'UTR luciferase reporter plasmidFASTKD2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FASTKD2

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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FASTKD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FASTKD2
    Addgene plasmids for FASTKD2 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FASTKD2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--

    Find genes that share ontologies with FASTKD2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FASTKD2
    Interactions:

        Search GeneGlobe Interaction Network for FASTKD2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for FASTKD2 (Q9NYY82, 3 ENSP000002369804) via UniProtKB, MINT, STRING, and/or I2D (see all 248)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    PHLDA3Q9Y5J53, ENSP000003562784I2D: score=1 STRING: ENSP00000356278
    TRAF6Q9Y4K33I2D: score=1 
    TSC22D1Q157143I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045333cellular respiration ISS--

    Find genes that share ontologies with FASTKD2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FASTKD2 (FAKD2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FASTKD2 gene (3 alternative transcripts): 
    NM_001136193.1  NM_001136194.1  NM_014929.3  

    Unigene Cluster for FASTKD2:

    FAST kinase domains 2
    Hs.5930  [show with all ESTs]
    Unigene Representative Sequence: NM_001136194
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000236980(uc002vbu.3 uc002vbv.3 uc002vbx.3) ENST00000418289
    ENST00000402774 ENST00000403094 ENST00000487777(uc002vbw.1) ENST00000471788

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FASTKD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FASTKD2 (see all 19):
    hsa-miR-549 hsa-miR-520d-5p hsa-miR-548s hsa-miR-583 hsa-miR-1323 hsa-miR-3613-3p hsa-miR-186 hsa-miR-3915
    SwitchGear 3'UTR luciferase reporter plasmidFASTKD2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FASTKD2
    Predesigned siRNA for gene silencing in human, mouse, rat FASTKD2
    Clone
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    OriGene clones in human, mouse for FASTKD2 (see all 17)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): FASTKD2 (NM_001136193)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FASTKD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FASTKD2
    Addgene plasmids for FASTKD2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FASTKD2
    OriGene qSTAR qPCR primer pairs in human, mouse for FASTKD2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FASTKD2
      QuantiTect SYBR Green Assays in human, mouse, rat FASTKD2
      QuantiFast Probe-based Assays in human, mouse, rat FASTKD2

    Additional mRNA sequence: 

    AF223470.1 AK001315.1 AK001516.1 AK021557.1 AL833877.1 BC001544.1 

    14 DOTS entries:

    DT.95272454  DT.313604  DT.409179  DT.97770921  DT.120991695  DT.75166799  DT.92437633  DT.101976445 
    DT.91678029  DT.100036806  DT.100817752  DT.120991756  DT.40220861  DT.75185990 

    Selected AceView cDNA sequences (see all 229):

    AI479715 BQ581674 CA313725 CA312272 BE874300 BM762657 BU625180 BQ954327 
    BM852503 BX102901 BU753874 AW613034 CF126553 BQ013388 AK129952 BX106519 
    CB322012 CF530070 AF223470 AK001315 BC001544 AI269266 BU623313 AI373235 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FASTKD2 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
    SP1:                    -                 -                                               -                                   -           -               
    SP2:              -     -                 -                                               -                                   -           -               
    SP3:                                      -                                               -                                                               
    SP4:                                                                                      -                 -                 -                           
    SP5:                                                                                                                          -                           


    ECgene alternative splicing isoforms for FASTKD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FASTKD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTTGTAAA
    FASTKD2 Expression
    About this image

    FASTKD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FASTKD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.5930
        Custom PCR Arrays for FASTKD2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FASTKD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FASTKD2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fastkd21 , 5 FAST kinase domains 21, 5 77.94(n)1
    66.76(a)1
      1 (32.31 cM)5
    756191  NM_172422.31  NP_766010.11 
     637306145 
    chicken
    (Gallus gallus)
    Aves FASTKD21 FAST kinase domains 2 58.24(n)
    44.98(a)
      424096  XM_421951.4  XP_421951.2 
    lizard
    (Anolis carolinensis)
    Reptilia FASTKD26
    FAST kinase domains 2
    41(a)
    1 ↔ 1
    GL343208.1(328019-346081)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fastkd21 FAST kinase domains 2 52(n)
    40.22(a)
      100488261  XM_002937116.2  XP_002937162.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fastkd21 FAST kinase domains 2 51.93(n)
    37.76(a)
      564382  XM_687718.6  XP_692810.5 


    ENSEMBL Gene Tree for FASTKD2 (if available)
    TreeFam Gene Tree for FASTKD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FASTKD2 (see all 736)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1840990431,2
    --207017508(+) CCAATC/GCATTC 3 -- us2k10--------
    rs781803491,2
    C,F--207017573(+) TCCTGG/CACTAT 3 -- us2k12Minor allele frequency- C:0.03NA 122
    rs1877371731,2
    --207017602(+) GGTTTA/CTTGGT 3 -- us2k10--------
    rs1899248111,2
    --207017636(+) ATAGCC/TGTAAC 3 -- us2k10--------
    rs1821801251,2
    --207017746(+) ATCTAC/TATTAT 3 -- us2k10--------
    rs1379168181,2
    --207017768(+) CTCACC/TTTATG 3 -- us2k10--------
    rs1872937421,2
    --207017814(+) ATAAAA/CTTATT 3 -- us2k10--------
    rs1928915851,2
    --207017879(+) TCTAAC/TCCCAC 3 -- us2k10--------
    rs64353491,2
    C,F,A,H--207017908(+) AAATTG/TCTCCC 3 -- us2k111Minor allele frequency- T:0.04NS EA NA WA 1548
    rs2017021021,2
    --207018012(+) TAAGG-/TTCCCT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for FASTKD2 (207630081 - 207660913 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FASTKD2: --
    Human Gene Mutation Database (HGMD): FASTKD2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FASTKD2
    DNA2.0 Custom Variant and Variant Library Synthesis for FASTKD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612322   
    OMIM disorders: 220110  
    2 diseases for FASTKD2:    
    About MalaCards
    fastkd2-related infantile mitochondrial encephalomyopathy    cytochrome-c oxidase deficiency disease

    2 diseases from the University of Copenhagen DISEASES database for FASTKD2:
    Mitochondrial encephalomyopathy     Hemiplegia

    Find genes that share disorders with FASTKD2           About GenesLikeMe

    Genetic Association Database (GAD): FASTKD2
    Human Genome Epidemiology (HuGE) Navigator: FASTKD2 (2 documents)

    Export disorders for FASTKD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FASTKD2 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with FASTKD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. (PubMed id 20966902)1, 4 Croteau-Chonka D.C....Mohlke K.L. (Obesity (Silver Spring) 2011)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    7. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    8. Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. (PubMed id 23459443)1 Avery C.L....Psaty B.M. (Pharmacogenomics J. 2013)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22868 HGNC: 29160 AceView: KIAA0971 Ensembl:ENSG00000118246 euGenes: HUgn22868
    ECgene: FASTKD2 H-InvDB: FASTKD2

    (According to HUGE)
    About This Section

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    HUGE: KIAA0971

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FASTKD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FASTKD2 gene:
    Search GeneIP for patents involving FASTKD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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