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Aliases for FASTKD1 Gene

Aliases for FASTKD1 Gene

  • FAST Kinase Domains 1 2 3 5
  • KIAA1800 4

External Ids for FASTKD1 Gene

Previous GeneCards Identifiers for FASTKD1 Gene

  • GC02M170094
  • GC02M170386
  • GC02M162276

Summaries for FASTKD1 Gene

GeneCards Summary for FASTKD1 Gene

FASTKD1 (FAST Kinase Domains 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and protein kinase activity. An important paralog of this gene is TBRG4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FASTKD1 Gene

Genomics for FASTKD1 Gene

Regulatory Elements for FASTKD1 Gene

Promoters for FASTKD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FASTKD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FASTKD1 Gene

Chromosome:
2
Start:
169,527,880 bp from pter
End:
169,573,921 bp from pter
Size:
46,042 bases
Orientation:
Minus strand

Genomic View for FASTKD1 Gene

Genes around FASTKD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FASTKD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FASTKD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FASTKD1 Gene

Proteins for FASTKD1 Gene

  • Protein details for FASTKD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53R41-FAKD1_HUMAN
    Recommended name:
    FAST kinase domain-containing protein 1
    Protein Accession:
    Q53R41
    Secondary Accessions:
    • Q8N583
    • Q8TEA9
    • Q96JM5
    • Q96N71
    • Q9H6T4

    Protein attributes for FASTKD1 Gene

    Size:
    847 amino acids
    Molecular mass:
    97411 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH32687.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15168.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FASTKD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FASTKD1 Gene

Proteomics data for FASTKD1 Gene at MOPED

Post-translational modifications for FASTKD1 Gene

  • Ubiquitination at Lys 785
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FASTKD1 Gene

Domains & Families for FASTKD1 Gene

Protein Domains for FASTKD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FASTKD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q53R41

UniProtKB/Swiss-Prot:

FAKD1_HUMAN :
  • Contains 1 RAP domain.
  • Belongs to the FAST kinase family.
Domain:
  • Contains 1 RAP domain.
Family:
  • Belongs to the FAST kinase family.
genes like me logo Genes that share domains with FASTKD1: view

No data available for Gene Families for FASTKD1 Gene

Function for FASTKD1 Gene

genes like me logo Genes that share phenotypes with FASTKD1: view

Animal Model Products

miRNA for FASTKD1 Gene

miRTarBase miRNAs that target FASTKD1

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FASTKD1 Gene

Localization for FASTKD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FASTKD1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FASTKD1 Gene COMPARTMENTS Subcellular localization image for FASTKD1 gene
Compartment Confidence
mitochondrion 5
nucleus 3
golgi apparatus 2
cytosol 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for FASTKD1 Gene

Pathways & Interactions for FASTKD1 Gene

SuperPathways for FASTKD1 Gene

No Data Available

Interacting Proteins for FASTKD1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000400513%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000301585%0d%0a
Selected Interacting proteins: Q53R41-FAKD1_HUMAN ENSP00000400513 for FASTKD1 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for FASTKD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with FASTKD1: view

No data available for Pathways by source and SIGNOR curated interactions for FASTKD1 Gene

Drugs & Compounds for FASTKD1 Gene

No Compound Related Data Available

Transcripts for FASTKD1 Gene

Unigene Clusters for FASTKD1 Gene

FAST kinase domains 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FASTKD1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - -
SP2: - - -
SP3: - - -
SP4: -
SP5: - - -
SP6:
SP7:

Relevant External Links for FASTKD1 Gene

GeneLoc Exon Structure for
FASTKD1
ECgene alternative splicing isoforms for
FASTKD1

Expression for FASTKD1 Gene

mRNA expression in normal human tissues for FASTKD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FASTKD1 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.2).

Protein differential expression in normal tissues from HIPED for FASTKD1 Gene

This gene is overexpressed in Nasal epithelium (35.4) and Bone (31.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for FASTKD1 Gene



SOURCE GeneReport for Unigene cluster for FASTKD1 Gene Hs.529276

mRNA Expression by UniProt/SwissProt for FASTKD1 Gene

Q53R41-FAKD1_HUMAN
Tissue specificity: Expression detected in spleen, thymus, testis, ovary, colon, heart, smooth muscle, kidney, brain, lung, liver and white adipose tissue with highest expression in heart.
genes like me logo Genes that share expression patterns with FASTKD1: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for FASTKD1 Gene

Orthologs for FASTKD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FASTKD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FASTKD1 35
  • 99.59 (n)
  • 99.51 (a)
FASTKD1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FASTKD1 36
  • 76 (a)
OneToOne
FASTKD1 35
  • 85.64 (n)
  • 76.17 (a)
dog
(Canis familiaris)
Mammalia FASTKD1 35
  • 85.8 (n)
  • 75.21 (a)
FASTKD1 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fastkd1 16
Fastkd1 35
  • 76.33 (n)
  • 68.84 (a)
Fastkd1 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FASTKD1 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 50 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fastkd1 35
  • 75.69 (n)
  • 67.03 (a)
chicken
(Gallus gallus)
Aves FASTKD1 36
  • 47 (a)
OneToOne
FASTKD1 35
  • 60.11 (n)
  • 46.97 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.19489 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fastkd1 35
  • 58.5 (n)
  • 47.57 (a)
Str.3931 35
zebrafish
(Danio rerio)
Actinopterygii fastkd1 36
  • 46 (a)
OneToOne
fastkd1 35
  • 53.8 (n)
  • 46.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31643 36
  • 16 (a)
OneToOne
Species with no ortholog for FASTKD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FASTKD1 Gene

ENSEMBL:
Gene Tree for FASTKD1 (if available)
TreeFam:
Gene Tree for FASTKD1 (if available)

Paralogs for FASTKD1 Gene

Paralogs for FASTKD1 Gene

(1) SIMAP similar genes for FASTKD1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for FASTKD1 Gene

genes like me logo Genes that share paralogs with FASTKD1: view

Variants for FASTKD1 Gene

Sequence variations from dbSNP and Humsavar for FASTKD1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs12618227 - 169,555,188(+) TAATT(A/C/G)TTGAG nc-transcript-variant, reference, missense
rs35106223 - 169,546,583(-) CACAG(G/T)GTGAC nc-transcript-variant, reference, missense
rs2253680 - 169,546,520(+) ATACA(C/T)GTGAT nc-transcript-variant, reference, missense
rs730685 -- 169,574,063(-) AGAAT(A/C)ACCTA upstream-variant-2KB
rs1446899 -- 169,538,753(+) CTAAG(G/T)AAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FASTKD1 Gene

Variant ID Type Subtype PubMed ID
dgv4357n71 CNV Loss 21882294
dgv4358n71 CNV Loss 21882294
dgv4359n71 CNV Loss 21882294
dgv4360n71 CNV Loss 21882294
nsv518894 CNV Gain 19592680
dgv4361n71 CNV Loss 21882294
nsv875398 CNV Gain+Loss 21882294
esv2721114 CNV Deletion 23290073
esv2660870 CNV Deletion 23128226

Variation tolerance for FASTKD1 Gene

Residual Variation Intolerance Score: 92.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.42; 63.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FASTKD1 Gene

HapMap Linkage Disequilibrium report
FASTKD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FASTKD1 Gene

Disorders for FASTKD1 Gene

Relevant External Links for FASTKD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FASTKD1

No disorders were found for FASTKD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FASTKD1 Gene

Publications for FASTKD1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. (PMID: 22681889) Baltz A.G. … Landthaler M. (Mol. Cell 2012) 3
  5. Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. (PMID: 20869947) Simarro M. … Anderson P. (Biochem. Biophys. Res. Commun. 2010) 3

Products for FASTKD1 Gene

Sources for FASTKD1 Gene

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