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Aliases for FASTKD1 Gene

Aliases for FASTKD1 Gene

  • FAST Kinase Domains 1 2 3
  • KIAA1800 4

External Ids for FASTKD1 Gene

Previous GeneCards Identifiers for FASTKD1 Gene

  • GC02M170094
  • GC02M170386
  • GC02M162276

Summaries for FASTKD1 Gene

GeneCards Summary for FASTKD1 Gene

FASTKD1 (FAST Kinase Domains 1) is a Protein Coding gene. GO annotations related to this gene include protein kinase activity. An important paralog of this gene is TBRG4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FASTKD1 Gene

Genomics for FASTKD1 Gene

Regulatory Elements for FASTKD1 Gene

Genomic Location for FASTKD1 Gene

169,529,749 bp from pter
169,573,921 bp from pter
44,173 bases
Minus strand

Genomic View for FASTKD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FASTKD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FASTKD1 Gene

Proteins for FASTKD1 Gene

  • Protein details for FASTKD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FAST kinase domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q8N583
    • Q8TEA9
    • Q96JM5
    • Q96N71
    • Q9H6T4

    Protein attributes for FASTKD1 Gene

    847 amino acids
    Molecular mass:
    97411 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH32687.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15168.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FASTKD1 Gene


neXtProt entry for FASTKD1 Gene

Proteomics data for FASTKD1 Gene at MOPED

Post-translational modifications for FASTKD1 Gene

  • Ubiquitination at Lys785
  • Modification sites at PhosphoSitePlus

Other Protein References for FASTKD1 Gene

No data available for DME Specific Peptides for FASTKD1 Gene

Domains for FASTKD1 Gene

Protein Domains for FASTKD1 Gene


Suggested Antigen Peptide Sequences for FASTKD1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q53R41
  • Contains 1 RAP domain.
  • Belongs to the FAST kinase family.
genes like me logo Genes that share domains with FASTKD1: view

No data available for Gene Families for FASTKD1 Gene

Function for FASTKD1 Gene

Gene Ontology (GO) - Molecular Function for FASTKD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with FASTKD1: view
genes like me logo Genes that share phenotypes with FASTKD1: view

Animal Model Products

CRISPR Products

miRNA for FASTKD1 Gene

miRTarBase miRNAs that target FASTKD1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FASTKD1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FASTKD1 Gene

Localization for FASTKD1 Gene

Subcellular locations from

Jensen Localization Image for FASTKD1 Gene COMPARTMENTS Subcellular localization image for FASTKD1 gene
Compartment Confidence
mitochondrion 5
nucleus 4
golgi apparatus 2
cytosol 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FASTKD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 20869947
genes like me logo Genes that share ontologies with FASTKD1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FASTKD1 Gene

Pathways for FASTKD1 Gene

SuperPathways for FASTKD1 Gene

No Data Available

Interacting Proteins for FASTKD1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q53R41-FAKD1_HUMAN ENSP00000400513 for FASTKD1 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for FASTKD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0045333 cellular respiration ISS 20869947
genes like me logo Genes that share ontologies with FASTKD1: view

No data available for Pathways by source for FASTKD1 Gene

Transcripts for FASTKD1 Gene

Unigene Clusters for FASTKD1 Gene

FAST kinase domains 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FASTKD1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FASTKD1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FASTKD1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - -
SP2: - - -
SP3: - - -
SP4: -
SP5: - - -

Relevant External Links for FASTKD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FASTKD1 Gene

mRNA expression in normal human tissues for FASTKD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FASTKD1 Gene

This gene is overexpressed in Heart - Left Ventricle (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FASTKD1 Gene

SOURCE GeneReport for Unigene cluster for FASTKD1 Gene Hs.529276

genes like me logo Genes that share expressions with FASTKD1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FASTKD1 Gene

Orthologs for FASTKD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FASTKD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FASTKD1 35
  • 99.59 (n)
  • 99.51 (a)
  • 100 (a)
(Bos Taurus)
Mammalia FASTKD1 35
  • 85.64 (n)
  • 76.17 (a)
  • 76 (a)
(Canis familiaris)
Mammalia FASTKD1 35
  • 85.8 (n)
  • 75.21 (a)
  • 76 (a)
(Mus musculus)
Mammalia Fastkd1 35
  • 76.33 (n)
  • 68.84 (a)
Fastkd1 16
Fastkd1 36
  • 69 (a)
(Monodelphis domestica)
Mammalia FASTKD1 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 50 (a)
-- 36
  • 54 (a)
(Rattus norvegicus)
Mammalia Fastkd1 35
  • 75.69 (n)
  • 67.03 (a)
(Gallus gallus)
Aves FASTKD1 35
  • 60.11 (n)
  • 46.97 (a)
  • 47 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
-- 36
  • 48 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19489 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fastkd1 35
  • 58.5 (n)
  • 47.57 (a)
Str.3931 35
(Danio rerio)
Actinopterygii fastkd1 35
  • 53.8 (n)
  • 46.08 (a)
fastkd1 36
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31643 36
  • 16 (a)
Species with no ortholog for FASTKD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FASTKD1 Gene

Gene Tree for FASTKD1 (if available)
Gene Tree for FASTKD1 (if available)

Paralogs for FASTKD1 Gene

Paralogs for FASTKD1 Gene

Selected SIMAP similar genes for FASTKD1 Gene using alignment to 5 proteins: Pseudogenes for FASTKD1 Gene

genes like me logo Genes that share paralogs with FASTKD1: view

Variants for FASTKD1 Gene

Sequence variations from dbSNP and Humsavar for FASTKD1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs730685 -- 169,574,063(-) AGAAT(A/C)ACCTA upstream-variant-2KB
rs746270 -- 169,573,525(+) GTCTC(A/G)GCCCT intron-variant
rs746271 -- 169,573,465(+) TAAGG(A/G)GTATC intron-variant
rs1446899 -- 169,538,753(+) CTAAG(G/T)AAACA intron-variant
rs1446903 -- 169,567,864(+) AACAA(C/T)AGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FASTKD1 Gene

Variant ID Type Subtype PubMed ID
dgv4357n71 CNV Loss 21882294
dgv4358n71 CNV Loss 21882294
dgv4359n71 CNV Loss 21882294
dgv4360n71 CNV Loss 21882294
nsv518894 CNV Gain 19592680
dgv4361n71 CNV Loss 21882294
nsv875398 CNV Gain+Loss 21882294
esv2721114 CNV Deletion 23290073
esv2660870 CNV Deletion 23128226

Relevant External Links for FASTKD1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FASTKD1 Gene

Disorders for FASTKD1 Gene

(1) University of Copenhagen DISEASES for FASTKD1 Gene

genes like me logo Genes that share disorders with FASTKD1: view

No data available for UniProtKB/Swiss-Prot for FASTKD1 Gene

Publications for FASTKD1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. (PMID: 20869947) Simarro M. … Anderson P. (Biochem. Biophys. Res. Commun. 2010) 3
  5. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3

Products for FASTKD1 Gene

  • antibodies-online proteins for FASTKD1
  • antibodies-online antibodies for FASTKD1
  • antibodies-online kits for FASTKD1

Sources for FASTKD1 Gene

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