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Aliases for FASTKD1 Gene

Aliases for FASTKD1 Gene

  • FAST Kinase Domains 1 2 3 5
  • KIAA1800 4

External Ids for FASTKD1 Gene

Previous GeneCards Identifiers for FASTKD1 Gene

  • GC02M170094
  • GC02M170386
  • GC02M162276

Summaries for FASTKD1 Gene

GeneCards Summary for FASTKD1 Gene

FASTKD1 (FAST Kinase Domains 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and protein kinase activity. An important paralog of this gene is FASTKD3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FASTKD1 Gene

Genomics for FASTKD1 Gene

Regulatory Elements for FASTKD1 Gene

Enhancers for FASTKD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F169572 1.1 ENCODE 19.6 +0.3 322 1.9 PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 FASTKD1 PHOSPHO2 KLHL23 GC02M169527
GH02F169714 1.1 Ensembl ENCODE 18.4 -142.5 -142466 3.2 PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 SLC30A9 GATA2 FASTKD1 PHOSPHO2 CCDC173 ENSG00000229827 GC02P169728 KLHL23
GH02F169693 0.4 ENCODE 17.2 -120.9 -120893 2.7 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 KLF13 PHOSPHO2 FASTKD1 CCDC173 SSB KLHL23 GC02P169728
GH02F169682 0.5 ENCODE 17.2 -109.5 -109452 1.7 MLX ARID4B DMAP1 YY1 SLC30A9 MXD4 PPARG KAT8 MIER3 ETV4 FASTKD1 PHOSPHO2 CYB5AP2 SSB GC02M169688 LOC100421474
GH02F169583 0.7 ENCODE 15.9 -11.2 -11230 2.9 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 PHOSPHO2 FASTKD1 CCDC173 SSB PPIG GC02P169639
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FASTKD1 on UCSC Golden Path with GeneCards custom track

Promoters for FASTKD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000124400 621 2201 PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for FASTKD1 Gene

Chromosome:
2
Start:
169,527,880 bp from pter
End:
169,573,921 bp from pter
Size:
46,042 bases
Orientation:
Minus strand

Genomic View for FASTKD1 Gene

Genes around FASTKD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FASTKD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FASTKD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FASTKD1 Gene

Proteins for FASTKD1 Gene

  • Protein details for FASTKD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53R41-FAKD1_HUMAN
    Recommended name:
    FAST kinase domain-containing protein 1, mitochondrial
    Protein Accession:
    Q53R41
    Secondary Accessions:
    • Q8N583
    • Q8TEA9
    • Q96JM5
    • Q96N71
    • Q9H6T4

    Protein attributes for FASTKD1 Gene

    Size:
    847 amino acids
    Molecular mass:
    97411 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH32687.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15168.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FASTKD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FASTKD1 Gene

Post-translational modifications for FASTKD1 Gene

  • Ubiquitination at Lys 785
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FASTKD1 Gene

Domains & Families for FASTKD1 Gene

Protein Domains for FASTKD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FASTKD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q53R41

UniProtKB/Swiss-Prot:

FAKD1_HUMAN :
  • Contains 1 RAP domain.
  • Belongs to the FAST kinase family.
Domain:
  • Contains 1 RAP domain.
Family:
  • Belongs to the FAST kinase family.
genes like me logo Genes that share domains with FASTKD1: view

No data available for Gene Families for FASTKD1 Gene

Function for FASTKD1 Gene

Gene Ontology (GO) - Molecular Function for FASTKD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with FASTKD1: view
genes like me logo Genes that share phenotypes with FASTKD1: view

Animal Model Products

miRNA for FASTKD1 Gene

miRTarBase miRNAs that target FASTKD1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FASTKD1 Gene

Localization for FASTKD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FASTKD1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FASTKD1 Gene COMPARTMENTS Subcellular localization image for FASTKD1 gene
Compartment Confidence
mitochondrion 5
nucleus 3
golgi apparatus 2
cytosol 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FASTKD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA 20869947
genes like me logo Genes that share ontologies with FASTKD1: view

Pathways & Interactions for FASTKD1 Gene

SuperPathways for FASTKD1 Gene

No Data Available

Interacting Proteins for FASTKD1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000400513%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000301585%0d%0a
Selected Interacting proteins: Q53R41-FAKD1_HUMAN ENSP00000400513 for FASTKD1 Gene via IID MINT STRING

Gene Ontology (GO) - Biological Process for FASTKD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0045333 cellular respiration ISS 20869947
genes like me logo Genes that share ontologies with FASTKD1: view

No data available for Pathways by source and SIGNOR curated interactions for FASTKD1 Gene

Transcripts for FASTKD1 Gene

Unigene Clusters for FASTKD1 Gene

FAST kinase domains 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FASTKD1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - -
SP2: - - -
SP3: - - -
SP4: -
SP5: - - -
SP6:
SP7:

Relevant External Links for FASTKD1 Gene

GeneLoc Exon Structure for
FASTKD1
ECgene alternative splicing isoforms for
FASTKD1

Expression for FASTKD1 Gene

mRNA expression in normal human tissues for FASTKD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FASTKD1 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.2).

Protein differential expression in normal tissues from HIPED for FASTKD1 Gene

This gene is overexpressed in Nasal epithelium (35.4) and Bone (31.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FASTKD1 Gene



NURSA nuclear receptor signaling pathways regulating expression of FASTKD1 Gene:

FASTKD1

SOURCE GeneReport for Unigene cluster for FASTKD1 Gene:

Hs.529276

mRNA Expression by UniProt/SwissProt for FASTKD1 Gene:

Q53R41-FAKD1_HUMAN
Tissue specificity: Expression detected in spleen, thymus, testis, ovary, colon, heart, smooth muscle, kidney, brain, lung, liver and white adipose tissue with highest expression in heart.
genes like me logo Genes that share expression patterns with FASTKD1: view

Primer Products

No data available for Protein tissue co-expression partners for FASTKD1 Gene

Orthologs for FASTKD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FASTKD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FASTKD1 34 35
  • 99.59 (n)
dog
(Canis familiaris)
Mammalia FASTKD1 34 35
  • 85.8 (n)
cow
(Bos Taurus)
Mammalia FASTKD1 34 35
  • 85.64 (n)
mouse
(Mus musculus)
Mammalia Fastkd1 34 16 35
  • 76.33 (n)
rat
(Rattus norvegicus)
Mammalia Fastkd1 34
  • 75.69 (n)
oppossum
(Monodelphis domestica)
Mammalia FASTKD1 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 54 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
chicken
(Gallus gallus)
Aves FASTKD1 34 35
  • 60.11 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 48 (a)
OneToMany
-- 35
  • 46 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fastkd1 34
  • 58.5 (n)
Str.3931 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.19489 34
zebrafish
(Danio rerio)
Actinopterygii fastkd1 34 35
  • 53.8 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG31643 35
  • 16 (a)
OneToOne
Species where no ortholog for FASTKD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FASTKD1 Gene

ENSEMBL:
Gene Tree for FASTKD1 (if available)
TreeFam:
Gene Tree for FASTKD1 (if available)

Paralogs for FASTKD1 Gene

Paralogs for FASTKD1 Gene

(1) SIMAP similar genes for FASTKD1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for FASTKD1 Gene

genes like me logo Genes that share paralogs with FASTKD1: view

Variants for FASTKD1 Gene

Sequence variations from dbSNP and Humsavar for FASTKD1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10186102 -- 169,554,105(+) catct(C/T)tacaa intron-variant
rs10186314 -- 169,554,277(+) tgtct(C/T)taaaa intron-variant
rs10186366 -- 169,575,277(+) ctggc(G/T)gggcg upstream-variant-2KB
rs10197423 -- 169,575,286(+) cgggg(A/G)gctga upstream-variant-2KB
rs10618482 -- 169,568,655(+) AAAAA(-/AA)GAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FASTKD1 Gene

Variant ID Type Subtype PubMed ID
dgv4104n100 CNV gain 25217958
dgv7157n54 CNV loss 21841781
esv2660870 CNV deletion 23128226
esv2721114 CNV deletion 23290073
esv3593325 CNV loss 21293372
nsv1011368 CNV loss 25217958
nsv475721 CNV novel sequence insertion 20440878
nsv518894 CNV gain 19592680
nsv583603 CNV loss 21841781

Variation tolerance for FASTKD1 Gene

Residual Variation Intolerance Score: 92.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.42; 63.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FASTKD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FASTKD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FASTKD1 Gene

Disorders for FASTKD1 Gene

Relevant External Links for FASTKD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FASTKD1

No disorders were found for FASTKD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FASTKD1 Gene

Publications for FASTKD1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  2. Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. (PMID: 20869947) Simarro M. … Anderson P. (Biochem. Biophys. Res. Commun. 2010) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64

Products for FASTKD1 Gene

Sources for FASTKD1 Gene

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