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Aliases for FASTK Gene

Aliases for FASTK Gene

  • Fas-Activated Serine/Threonine Kinase 2 3
  • FAST Kinase 3 4
  • FAST 3 6
  • EC 2.7.11.8 4

External Ids for FASTK Gene

Summaries for FASTK Gene

Entrez Gene Summary for FASTK Gene

  • The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for FASTK Gene

FASTK (Fas-Activated Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with FASTK include autism spectrum disorder. GO annotations related to this gene include protein serine/threonine kinase activity and Fas-activated serine/threonine kinase activity. An important paralog of this gene is FASTKD1.

UniProtKB/Swiss-Prot for FASTK Gene

  • Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor.

Gene Wiki entry for FASTK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FASTK Gene

Genomics for FASTK Gene

Genomic Location for FASTK Gene

Start:
151,076,593 bp from pter
End:
151,080,883 bp from pter
Size:
4,291 bases
Orientation:
Minus strand

Genomic View for FASTK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FASTK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FASTK Gene

Regulatory Elements for FASTK Gene

Proteins for FASTK Gene

  • Protein details for FASTK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14296-FASTK_HUMAN
    Recommended name:
    Fas-activated serine/threonine kinase
    Protein Accession:
    Q14296
    Secondary Accessions:
    • A8K867
    • F8VTW9
    • Q59EM8
    • Q8IVA0

    Protein attributes for FASTK Gene

    Size:
    549 amino acids
    Molecular mass:
    61104 Da
    Quaternary structure:
    • Interacts with TIA-1 and TIAR.
    SequenceCaution:
    • Sequence=BAD93020.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FASTK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FASTK Gene

Proteomics data for FASTK Gene at MOPED

Post-translational modifications for FASTK Gene

  • Autophosphorylated on serine/threonine residues. Activated by dephosphorylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FASTK Gene

No data available for DME Specific Peptides for FASTK Gene

Domains for FASTK Gene

Protein Domains for FASTK Gene

Suggested Antigen Peptide Sequences for FASTK Gene

Graphical View of Domain Structure for InterPro Entry

Q14296

UniProtKB/Swiss-Prot:

FASTK_HUMAN
Domain:
  • Contains 1 RAP domain.:
    • Q14296
Family:
  • Belongs to the FAST protein kinase family.:
    • Q14296
genes like me logo Genes that share domains with FASTK: view

No data available for Gene Families for FASTK Gene

Function for FASTK Gene

Molecular function for FASTK Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine phosphoprotein]
UniProtKB/Swiss-Prot Function: Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor.

Enzyme Numbers (IUBMB) for FASTK Gene

Gene Ontology (GO) - Molecular Function for FASTK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 7544399
GO:0005515 protein binding IPI 15110758
GO:0005524 ATP binding IEA --
GO:0033867 Fas-activated serine/threonine kinase activity IEA --
genes like me logo Genes that share ontologies with FASTK: view
genes like me logo Genes that share phenotypes with FASTK: view

Animal Models for FASTK Gene

MGI Knock Outs for FASTK:

miRNA for FASTK Gene

miRTarBase miRNAs that target FASTK

No data available for Transcription Factor Targeting and HOMER Transcription for FASTK Gene

Localization for FASTK Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FASTK Gene COMPARTMENTS Subcellular localization image for FASTK gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FASTK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with FASTK: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FASTK Gene

Pathways for FASTK Gene

SuperPathways for FASTK Gene

No Data Available

Gene Ontology (GO) - Biological Process for FASTK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 7544399
GO:0043484 regulation of RNA splicing IMP 17592127
GO:0097190 apoptotic signaling pathway TAS 7544399
genes like me logo Genes that share ontologies with FASTK: view

No data available for Pathways by source for FASTK Gene

Compounds for FASTK Gene

(2) HMDB Compounds for FASTK Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(2) Novoseek inferred chemical compound relationships for FASTK Gene

Compound -log(P) Hits PubMed IDs
threonine 58.8 7
serine 46.8 7
genes like me logo Genes that share compounds with FASTK: view

Transcripts for FASTK Gene

Unigene Clusters for FASTK Gene

Fas-activated serine/threonine kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FASTK Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - -
SP6: -
SP7: -
SP8: - - - - - -
SP9: - - - -
SP10: - - - - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - - - - -
SP13: - - - - -
SP14: - - - - - - -
SP15: - - -
SP16:
SP17: - -
SP18:
SP19:

ExUns: 12a · 12b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for FASTK Gene

GeneLoc Exon Structure for
FASTK
ECgene alternative splicing isoforms for
FASTK

Expression for FASTK Gene

mRNA expression in normal human tissues for FASTK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FASTK Gene

SOURCE GeneReport for Unigene cluster for FASTK Gene Hs.647094

mRNA Expression by UniProt/SwissProt for FASTK Gene

Q14296-FASTK_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas
genes like me logo Genes that share expressions with FASTK: view

No data available for mRNA differential expression in normal tissues for FASTK Gene

Orthologs for FASTK Gene

This gene was present in the common ancestor of chordates.

Orthologs for FASTK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FASTK 35
  • 99.7 (n)
  • 99.82 (a)
FASTK 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FASTK 35
  • 90.34 (n)
  • 92.25 (a)
FASTK 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FASTK 35
  • 91.2 (n)
  • 93.99 (a)
FASTK 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fastk 35
  • 86.67 (n)
  • 89.54 (a)
Fastk 16
Fastk 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FASTK 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fastk 35
  • 87.41 (n)
  • 90.82 (a)
chicken
(Gallus gallus)
Aves FASTK 35
  • 62.83 (n)
  • 54 (a)
FASTK 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FASTK 36
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii Dr.13216 35
fastk 35
  • 54.87 (n)
  • 47.13 (a)
fastk 36
  • 25 (a)
OneToOne
Species with no ortholog for FASTK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FASTK Gene

ENSEMBL:
Gene Tree for FASTK (if available)
TreeFam:
Gene Tree for FASTK (if available)

Paralogs for FASTK Gene

Paralogs for FASTK Gene

Selected SIMAP similar genes for FASTK Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FASTK: view

Variants for FASTK Gene

Sequence variations from dbSNP and Humsavar for FASTK Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1049365 -- 151,079,816(-) TGTTT(A/G)GGGCC synonymous-codon, reference, intron-variant
rs1130560 -- 151,077,103(-) GCCCA(A/G)AGGGT synonymous-codon, reference
rs2288648 - 151,077,221(+) TGCTG(A/G)CGCAC reference, missense
rs2303942 -- 151,078,219(+) CCTCC(A/G)GCCTC intron-variant
rs2303943 -- 151,078,257(+) CTGCA(A/C)GTGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FASTK Gene

Variant ID Type Subtype PubMed ID
nsv889465 CNV Loss 21882294
nsv526410 CNV Loss 19592680
nsv889476 CNV Loss 21882294
nsv889477 CNV Loss 21882294
dgv7545n71 CNV Loss 21882294
nsv831188 CNV Loss 17160897
dgv7546n71 CNV Loss 21882294
nsv517508 CNV Loss 19592680
nsv465215 CNV Loss 19166990
nsv6004 CNV Insertion 18451855
dgv7547n71 CNV Loss 21882294
dgv7548n71 CNV Loss 21882294

Relevant External Links for FASTK Gene

HapMap Linkage Disequilibrium report
FASTK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FASTK Gene

Disorders for FASTK Gene

(1) MalaCards Diseases for FASTK Gene

Search for FASTK Gene in MalaCards »

(1) University of Copenhagen DISEASES for FASTK Gene

(2) Novoseek inferred disease relationships for FASTK Gene

Disease -log(P) Hits PubMed IDs
necrosis 2.93 1
tumors 0 2

Relevant External Links for FASTK

Genetic Association Database (GAD)
FASTK
Human Genome Epidemiology (HuGE) Navigator
FASTK
genes like me logo Genes that share disorders with FASTK: view

No data available for UniProtKB/Swiss-Prot for FASTK Gene

Publications for FASTK Gene

  1. Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis. (PMID: 7544399) Tian Q. … Anderson P. (J. Exp. Med. 1995) 2 3 4 23
  2. FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression. (PMID: 15572676) Li W. … Anderson P. (Mol. Cell. Biol. 2004) 2 3 23
  3. Fas-activated serine/threonine kinase (FAST K) synergizes with TIA- 1/TIAR proteins to regulate Fas alternative splicing. (PMID: 17135269) Izquierdo J.M. … Valcarcel J. (J. Biol. Chem. 2007) 3 4
  4. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PMID: 19058789) de Krom M. … van Ree J.M. (Biol. Psychiatry 2009) 3 48
  5. FAST is a BCL-X(L)-associated mitochondrial protein. (PMID: 15110758) Li W. … Anderson P. (Biochem. Biophys. Res. Commun. 2004) 3 23

Products for FASTK Gene

  • Addgene plasmids for FASTK

Sources for FASTK Gene

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