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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FASTK Gene

protein-coding   GIFtS: 58
GCID: GC07M150773

Fas-Activated Serine/Threonine Kinase

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fas-Activated Serine/Threonine Kinase1 2
FAST Kinase2 3
FAST2 5
EC 2.7.11.83

External Ids:    HGNC: 246761   Entrez Gene: 109222   Ensembl: ENSG000001648967   OMIM: 6069655   UniProtKB: Q142963   

Export aliases for FASTK gene to outside databases

Previous GC identifers: GC07M149020 GC07M150088 GC07M150165 GC07M150211 GC07M150404 GC07M144586


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FASTK Gene:
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown
to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it
phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer
of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other
variants exist, but their full-length natures have not yet been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for FASTK Gene: 
FASTK (Fas-activated serine/threonine kinase) is a protein-coding gene. Diseases associated with FASTK include occupational dermatitis, and vestibular nystagmus. GO annotations related to this gene include protein serine/threonine kinase activity and Fas-activated serine/threonine kinase activity. An important paralog of this gene is TBRG4.

UniProtKB/Swiss-Prot: FASTK_HUMAN, Q14296
Function: Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads
to an mRNA encoding a pro-apoptotic form of the receptor

Gene Wiki entry for FASTK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007914.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FASTK gene promoter:
         GR   p53   GR-beta   GR-alpha   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FASTK promoter sequence
   Search SABiosciences Chromatin IP Primers for FASTK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FASTK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q35   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q35

FASTK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FASTK gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M150773:  view genomic region     (about GC identifiers)

Start:
150,773,708 bp from pter      End:
150,777,953 bp from pter
Size:
4,246 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 150,103,248-150,107,491     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FASTK_HUMAN, Q14296 (See protein sequence)
Recommended Name: Fas-activated serine/threonine kinase  
Size: 549 amino acids; 61104 Da
Subunit: Interacts with TIA-1 and TIAR
Sequence caution: Sequence=BAD93020.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8K867 F8VTW9 Q59EM8 Q8IVA0
Alternative splicing: 3 isoforms:  Q14296-1   Q14296-2   Q14296-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FASTK: NX_Q14296

Explore proteomics data for FASTK at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated on serine/threonine residues. Activated by dephosphorylation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14296

  • FASTK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FASTK Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001245390.1  NP_006703.1  NP_148936.2  

    ENSEMBL proteins: 
     ENSP00000324817   ENSP00000297532   ENSP00000418516   ENSP00000444498  

    Human Recombinant Protein Products for FASTK: 
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    Novus Biologicals FASTK Proteins
    Novus Biologicals FASTK Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FASTK 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--

    FASTK for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for FASTK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR010622 FAST_Leu-rich
     IPR013584 RAP
     IPR013579 FAST_2
     IPR015715 Ser/Thr_kinase_FAST

    Graphical View of Domain Structure for InterPro Entry Q14296

    ProtoNet protein and cluster: Q14296

    2 Blocks protein domains:
    IPB013579 FAST kinase-like protein
    IPB013584 RAP domain


    UniProtKB/Swiss-Prot: FASTK_HUMAN, Q14296
    Similarity: Belongs to the FAST protein kinase family
    Similarity: Contains 1 RAP domain


    FASTK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FASTK_HUMAN, Q14296
    Function: Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads
    to an mRNA encoding a pro-apoptotic form of the receptor
    Catalytic activity: ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine
    phosphoprotein]

         Enzyme Number (IUBMB): EC 2.7.11.81

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA7544399
    GO:0005515protein binding IPI15110758
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----
         
    FASTK for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fastk):
     hematopoietic system  homeostasis/metabolism  immune system 

    FASTK for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fastktm1.1Andp for FASTK

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FASTK 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FASTK

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FASTK


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FASTK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/9 Interacting proteins for FASTK (Q142963 ENSP000002975324) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBPMSQ930623, ENSP000003401764I2D: score=3 STRING: ENSP00000340176
    CRKP461083, ENSP000003005744I2D: score=2 STRING: ENSP00000300574
    TIA1P314833, ENSP000004013714I2D: score=2 STRING: ENSP00000401371
    CALCOCO2Q131373, ENSP000002589474I2D: score=3 STRING: ENSP00000258947
    MDFIQ997503, ENSP000002303214I2D: score=3 STRING: ENSP00000230321
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA7544399
    GO:0043484regulation of RNA splicing IMP17592127
    GO:0097190apoptotic signaling pathway TAS7544399

    FASTK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FASTK for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FASTK

    2 HMDB Compounds for FASTK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    2 Novoseek inferred chemical compound relationships for FASTK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 58.8 8 17592127 (2), 7544399 (2), 18649053 (1), 15110758 (1) (see all 5)
    serine 46.8 8 17592127 (2), 7544399 (2), 18649053 (1), 15110758 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about FASTK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FASTK gene (3 alternative transcripts): 
    NM_001258461.1  NM_006712.4  NM_033015.3  

    Unigene Cluster for FASTK:

    Fas-activated serine/threonine kinase
    Hs.647094  [show with all ESTs]
    Unigene Representative Sequence: NM_006712
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000489884(uc003wiw.1) ENST00000465272 ENST00000467237 ENST00000353841
    ENST00000297532(uc003wix.1) ENST00000482571(uc003wiz.1) ENST00000460980(uc003wiy.1)
    ENST00000469237 ENST00000482806 ENST00000483953 ENST00000466855 ENST00000459800
    ENST00000478477 ENST00000461979 ENST00000478883 ENST00000496663 ENST00000540185(uc003wja.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate FASTK (see all 21):
    hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-miR-93 hsa-miR-520g hsa-miR-526b* hsa-miR-17 hsa-miR-130b
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    Additional mRNA sequence: 

    AB209783.1 AK223132.1 AK292232.1 BC000377.2 BC006386.2 BC011770.2 BC039026.2 X86779.1 

    24/31 DOTS entries (see all 31):

    DT.449627  DT.75139864  DT.100887325  DT.100887336  DT.100887331  DT.100887324  DT.100887321  DT.91642064 
    DT.100887320  DT.98131849  DT.91880944  DT.121074452  DT.97855030  DT.100887330  DT.97855032  DT.100887337 
    DT.100887316  DT.100887327  DT.100887339  DT.121074388  DT.121074427  DT.40115637  DT.100887333  DT.100887319 

    24/631 AceView cDNA sequences (see all 631):

    BM772679 BM761482 BX364360 CD671103 BF724939 BQ677384 BE311994 AI802272 
    CA425735 CA405449 BC011770 BM709099 CR623465 BM552664 BX410184 CB852168 
    BM559407 BM052908 CK821300 BG056195 BC000936 BU166717 BM844796 BC006386 

    GeneLoc Exon Structure

    5/19 Alternative Splicing Database (ASD) splice patterns (SP) for FASTK (see all 19)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^
    SP1:                          -     -                 -     -                                               -                                   -               
    SP2:                          -     -                 -     -           -     -                             -                                   -               
    SP3:                          -     -     -     -     -     -                                               -                                   -               
    SP4:                                      -     -     -     -           -     -                             -                                   -               
    SP5:                          -     -     -           -     -           -     -                                                                                 

    ExUns: 12a · 12b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for FASTK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FASTK expression in normal human tissues (normalized intensities)      FASTK embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGGTGGAT
    FASTK Expression
    About this image


    FASTK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/27 selected tissues (see all 27) fully expand
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
             heart muscle ; myocytes   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex

    See FASTK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FASTK

    SOURCE GeneReport for Unigene cluster: Hs.647094

    UniProtKB/Swiss-Prot: FASTK_HUMAN, Q14296
    Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas

        SABiosciences Expression via Pathway-Focused PCR Array including FASTK: 
              Apoptosis 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FASTK gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fastk1 , 5 Fas-activated serine/threonine kinase1, 5 86.67(n)1
    89.54(a)1
      5 (11.78 cM)5
    665871  NM_023229.21  NP_075718.21 
     244384405 
    chicken
    (Gallus gallus)
    Aves FASTK6
    Fas-activated serine/threonine kinase
    45(a)
    1 ↔ 1
    2(275327-284996)
    lizard
    (Anolis carolinensis)
    Reptilia FASTK6
    Uncharacterized protein
    45(a)
    1 ↔ 1
    GL344454.1(21848-27089)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.132162 Transcribed sequence with weak similarity to protein more 75.62(n)    BI885083.1 


    ENSEMBL Gene Tree for FASTK (if available)
    TreeFam Gene Tree for FASTK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FASTK gene
    TBRG42  FASTKD32  FASTKD12  
    1 SIMAP similar gene for FASTK using alignment to 3 protein entries:     FASTK_HUMAN (see all proteins):
    DKFZp667F1810

    FASTK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/51 SNPs in FASTK are shown (see all 51)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0422004
    A lung adenocarcinoma sample4--see VAR_0422002 V L mis40--------
    VAR_0219704
    ----see VAR_0219702 A V mis40--------
    rs2001000381,2
    C--150775622(+) GAGATG/ACACTG 3 -- int11Minor allele frequency- A:0.00EU 1323
    rs1496382971,2
    C,F--150775724(+) AACCGG/ATGCCG 6 /H syn11Minor allele frequency- A:0.00NA 4520
    rs1418972331,2
    C--150775828(+) CGGACC/TTCCGG 3 -- int11Minor allele frequency- T:0.00EU 655
    rs1813775131,2
    C--150775895(+) CCCTCC/TCCACC 3 -- int10--------
    rs1483776391,2
    C,F--150775935(+) TGCCAG/AGCTGC 5 /L syn1 int11Minor allele frequency- A:0.00NA 3954
    rs1865834511,2
    C--150775948(+) ATCAGA/CTGCTG 5 Q H mis1 int11Minor allele frequency- C:0.00EU 1319
    rs2009954041,2
    --150775981(+) GGGCAA/GCTTAG 5 S syn1 int10--------
    rs1998461901,2
    C--150776012(+) CACCTC/TGGAGA 6 Q R mis11Minor allele frequency- T:0.00EU 1239

    HapMap Linkage Disequilibrium report for FASTK (150773708 - 150777953 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for FASTK (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv6004CNV Insertion18451855
    nsv517508CNV Loss19592680
    dgv7547n71CNV Loss21882294
    dgv7546n71CNV Loss21882294
    dgv7548n71CNV Loss21882294
    nsv889477CNV Loss21882294
    nsv465215CNV Loss19166990
    nsv889465CNV Loss21882294
    nsv526410CNV Loss19592680
    dgv7545n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606965    OMIM disorders: --

    12 diseases for FASTK:    About MalaCards
    occupational dermatitis    vestibular nystagmus    autism spectrum disorder    atopy
    hyperglycemia    dermatitis    hepatitis b    asthma
    adenoma    hepatitis    gastric cancer    neuronitis

    1 disease from the University of Copenhagen DISEASES database for FASTK:
    Cystadenoma

    FASTK for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for FASTK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 2.93 1 16162475 (1)
    tumors 0 2 16162475 (1), 17695722 (1)

    Genetic Association Database (GAD): FASTK
    Human Genome Epidemiology (HuGE) Navigator: FASTK (3 documents)

    Export disorders for FASTK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FASTK gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with FASTK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis. (PubMed id 7544399)1, 2, 3, 9 Tian Q.... Anderson P. (1995)
    2. FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression. (PubMed id 15572676)1, 3, 9 Li W....Anderson P. (2004)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (2009)
    5. Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing. (PubMed id 17135269)1, 2 Izquierdo J.M. and Valcarcel J. (2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing. (PubMed id 17592127)1, 9 Simarro M....Anderson P. (2007)
    9. FAST is a BCL-X(L)-associated mitochondrial protein. (PubMed id 15110758)1, 9 Li W....Anderson P. (2004)
    10. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10922 HGNC: 24676 AceView: FASTKandC7orf21 Ensembl:ENSG00000164896 euGenes: HUgn10922
    ECgene: FASTK H-InvDB: FASTK

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FASTK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FASTK gene:
    Search GeneIP for patents involving FASTK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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