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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FASTK Gene

protein-coding GIFtS: 56
GCID: GC07M150773

Fas-activated serine/threonine kinase

Explore 13 diseases affiliated with
FASTK via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Fas-Activated Serine/Threonine Kinase¹ ²
FAST¹ ² ⁵
FAST Kinase² ³
EC 2.7.11.8³

External Ids:	HGNC: 24676¹	Entrez Gene: 10922²	Ensembl: ENSG00000164896⁷	OMIM: 606965⁵	UniProtKB: Q14296³

Export aliases for FASTK gene to outside databases

Previous GC identifers: GC07M149020 GC07M150088 GC07M150165 GC07M150211 GC07M150404 GC07M144586

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FASTK:

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be

activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it

phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of

lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other

variants exist, but their full-length natures have not yet been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FASTK_HUMAN, Q14296

Function: Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an

mRNA encoding a pro-apoptotic form of the receptor

Gene Wiki entry for FASTK

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FASTK gene promoter:
GR p53 GR-beta GR-alpha C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FASTK promoter sequence

Search SABiosciences Chromatin IP Primers for FASTK

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FASTK

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q35 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q35

FASTK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FASTK gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M150773: view genomic region (about GC identifiers)

Start:	150,773,679 bp from pter	End:	150,777,953 bp from pter
Size:	4,275 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 150,103,248-150,107,491

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FASTK_HUMAN, Q14296 (See protein sequence)

Recommended Name: Fas-activated serine/threonine kinase

Size: 549 amino acids; 61104 Da

Subunit: Interacts with TIA-1 and TIAR

Sequence caution: Sequence=BAD93020.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: A8K867 F8VTW9 Q59EM8 Q8IVA0

Alternative splicing: 3 isoforms: Q14296-1 Q14296-2 Q14296-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FASTK: NX_Q14296

Post-translational modifications:

Autophosphorylated on serine/threonine residues. Activated by dephosphorylation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q14296

FASTK Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001245390.1 NP_006703.1 NP_148936.2

ENSEMBL proteins:

ENSP00000418781 ENSP00000324817 ENSP00000297532 ENSP00000418516 ENSP00000444498

Human Recombinant Protein Products for FASTK:

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	OriGene Purified Protein: FASTK OriGene Protein Over-expression Lysate (see all 2): FASTK OriGene Custom Protein Services for FASTK
	GenScript Custom Purified and Recombinant Proteins Services for FASTK
	Novus Biologicals FASTK Proteins Novus Biologicals FASTK Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for FASTK

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--

FASTK for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for FASTK

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FASTK for domains About GeneDecksing

4 InterPro domains/families:

IPR010622 FAST_Leu-rich

IPR013584 RAP

IPR013579 FAST_2

IPR015715 Ser/Thr_kinase_FAST

Graphical View of Domain Structure for InterPro Entry Q14296

ProtoNet protein and cluster: Q14296

2 Blocks protein families:

IPB013579 FAST kinase-like protein

IPB013584 RAP domain

UniProtKB/Swiss-Prot: FASTK_HUMAN, Q14296

Similarity: Belongs to the FAST protein kinase family

Similarity: Contains 1 RAP domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: FASTK_HUMAN, Q14296

Function: Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an

mRNA encoding a pro-apoptotic form of the receptor

Catalytic activity: ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine

phosphoprotein]

Enzyme Number (IUBMB): EC 2.7.11.8¹

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004672	protein kinase activity	--	--
GO:0004674	protein serine/threonine kinase activity	IDA	7544399
GO:0005515	protein binding	IPI	7544399
GO:0005524	ATP binding	IEA	--
GO:0016301	kinase activity	--	--

FASTK for ontologies About GeneDecksing

Phenotypes:
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Fastk):

hematopoietic system

homeostasis/metabolism

immune system

FASTK for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Fastk^tm1.1Andp for FASTK

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FASTK

miRNA Products:		OriGene 3'-UTR Clone (see all 2): FASTK Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FASTK
		8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate FASTK (see all 21):
		hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-miR-93 hsa-miR-520g hsa-miR-526b* hsa-miR-17 hsa-miR-130b

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FASTK (see all 7) OriGene shRNA RFP: FASTK OriGene siRNA: FASTK
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FASTK
		Sirion Biotech Custom design and validation of potent shRNA sequences against FASTK

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for FASTK
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FASTK (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FASTK (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): FASTK (NM_033015)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FASTK

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FASTK

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/9 Interacting proteins for FASTK (Q14296³ ENSP00000297532⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RBPMS	Q93062³, ENSP00000340176⁴	I2D: score=3 STRING: ENSP00000340176
CRK	P46108³, ENSP00000300574⁴	I2D: score=2 STRING: ENSP00000300574
TIA1	P31483³, ENSP00000401371⁴	I2D: score=2 STRING: ENSP00000401371
CALCOCO2	Q13137³, ENSP00000258947⁴	I2D: score=3 STRING: ENSP00000258947
MDFI	Q99750³, ENSP00000230321⁴	I2D: score=3 STRING: ENSP00000230321

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein phosphorylation	IDA	7544399
GO:0006915	apoptotic process	--	--
GO:0043484	regulation of RNA splicing	IMP	17592127
GO:0097190	apoptotic signaling pathway	TAS	7544399

FASTK for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FASTK for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FASTK

2 HMDB Compounds for FASTK About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--

2 Novoseek chemical compound relationships for FASTK gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	58.8	8	17592127 (2), 7544399 (2), 18649053 (1), 15110758 (1) (see all 5)
serine	46.8	8	17592127 (2), 7544399 (2), 18649053 (1), 15110758 (1) (see all 5)

Search CenterWatch for drugs/clinical trials and news about FASTK

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FASTK gene (3 alternative transcripts):

NM_001258461.1 NM_006712.4 NM_033015.3

Unigene Cluster for FASTK:

Fas-activated serine/threonine kinase

Hs.647094 [show with all ESTs]

Unigene Representative Sequence: NM_006712

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000483105 ENST00000489884(uc003wiw.1) ENST00000465272 ENST00000467237

ENST00000353841 ENST00000297532(uc003wix.1) ENST00000482571(uc003wiz.1)

ENST00000460980(uc003wiy.1) ENST00000469237 ENST00000482806 ENST00000483953

ENST00000466855 ENST00000459800 ENST00000478477 ENST00000461979 ENST00000478883

ENST00000496663 ENST00000540185(uc003wja.1)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): FASTK Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FASTK
		8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate FASTK (see all 21):
		hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-miR-93 hsa-miR-520g hsa-miR-526b* hsa-miR-17 hsa-miR-130b

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FASTK (see all 7) OriGene shRNA RFP: FASTK OriGene siRNA: FASTK
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FASTK
		Sirion Biotech Custom design and validation of potent shRNA sequences against FASTK

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FASTK (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FASTK (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): FASTK (NM_033015)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FASTK
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FASTK

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FASTK Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FASTK
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FASTK

Additional cDNA sequence:

AB209783.1 AK223132.1 AK292232.1 BC000377.2 BC006386.2 BC011770.2 BC039026.2 X86779.1

24/31 DOTS entries (see all 31):

DT.449627 DT.75139864 DT.100887325 DT.100887336 DT.100887331 DT.100887324 DT.100887321 DT.91642064

DT.100887320 DT.98131849 DT.91880944 DT.121074452 DT.97855030 DT.100887330 DT.97855032 DT.100887337

DT.100887316 DT.100887327 DT.100887339 DT.121074388 DT.121074427 DT.40115637 DT.100887333 DT.100887319

24/631 AceView cDNA sequences (see all 631):

BM142075 BM844796 BQ223605 BC033182 CA405449 CR623848 BX410184 CR611266

BM052855 BM923936 BU166717 AW205490 BU508454 BX388146 BU622580 BM772679

AA877731 BM799420 F06007 BU190561 NM_031434 BQ217247 NM_006712 CR604089

GeneLoc Exon Structure

5/19 Alternative Splicing Database (ASD) splice patterns (SP) for FASTK (see all 19) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2a	·	2b	^	3a	·	3b	·	3c	·	3d	·	3e	^	4a	·	4b	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^
SP1:									-		-						-		-																-												-
SP2:									-		-						-		-				-		-										-												-
SP3:									-		-		-		-		-		-																-												-
SP4:													-		-		-		-				-		-										-												-
SP5:									-		-		-				-		-				-		-

ExUns:	12a	·	12b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for FASTK

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FASTK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGGGTGGAT

About this image

FASTK expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Atrioventricular Canal

Atrioventricular Canal Cells

Myocardium

Heart

Outflow Tract

Heart

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FASTK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FASTK

SOURCE GeneReport for Unigene cluster: Hs.647094

UniProtKB/Swiss-Prot: FASTK_HUMAN, Q14296

Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas

SABiosciences Expression via Pathway-Focused PCR Array including FASTK:

Apoptosis 384HT in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FASTK

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FASTK gene from 2/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	FASTK⁶	--	46(a)	1 ↔ 1	GL344454.1(21863-26728)
zebrafish (Danio rerio)	Actinopterygii	Dr.13216²	Transcribed sequence with weak similarity to protein more	75.62(n)		BI885083.1

ENSEMBL Gene Tree for FASTK (if available)
TreeFam Gene Tree for FASTK (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FASTK gene

TBRG4² FASTKD1² FASTKD3²

1 SIMAP similar gene for FASTK using alignment to 4 protein entries: FASTK_HUMAN (see all proteins):

DKFZp667F1810

FASTK for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2303943^1,2	C,F,H	--	150104884(+)	`CTGCAC/AGTGAC`	1	--	us2k¹		19		EA NS NA WA CSA	3022
rs201972478^1,2	C	--	150774120(+)	`CTGCAG/TGGGGA`	4	--	us2k¹ int¹		1		EU	539
rs201230993^1,2		--	150774121(+)	`TGCAGA/GGGGAG`	4	--	us2k¹ int¹		0	--	--	--	--
rs139030865^1,2	C	--	150774148(+)	`ATGGCA/GGGCAA`	4	--	int¹ us2k¹		0	--	--	--	--
rs199875725^1,2		--	150774197(+)	`GGGCAC/GGGTCT`	7	P R	mis¹ us2k¹		0	--	--	--	--
rs149426387^1,2	C	--	150774283(+)	`CTCACA/GGGAAG`	7	P	syn¹ us2k¹		0	--	--	--	--
rs2288648^1,2	C,F,H	--	150774308(+)	`TGCTGG/ACGCAC`	7	/A /V	mis¹ us2k¹ ese³		24		EA NS NA CSA WA EU	8329
rs140296804^1,2	C	--	150774467(+)	`AACCCC/TTCAGC`	7	E	syn¹ us2k¹		1		NA	4418
rs189454687^1,2	C	--	150774997(+)	`GAAAAA/GACAAA`	7	V	us2k¹ syn¹		0	--	--	--	--
rs77703662^1,2	C	--	150775028(-)	`ACTGCA/GGTGCC`	7	Q R	us2k¹ mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FASTK (150773679 - 150777953 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FASTK
2 CNVs: 52152 4574

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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FASTK for disorders           About GeneDecksing

OMIM gene information: 606965    OMIM disorders: --

13 diseases for FASTK:    About MalaCards

vestibular nystagmus occupational dermatitis autism spectrum disorder nystagmus

atopy hepatitis b hyperglycemia dermatitis

asthma adenoma hepatitis immunodeficiency

neuronitis

2 diseases from the University of Copenhagen DISEASES database for FASTK:

Occupational dermatitis Vestibular nystagmus

2 Novoseek disease relationships for FASTK gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	2.93	1	16162475 (1)
tumors	0	2	16162475 (1), 17695722 (1)

Human Genome Epidemiology (HuGE) Navigator: FASTK (3 documents)

Export disorders for FASTK gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for FASTK gene, integrated from 9 sources (see all 27):
(articles sorted by number of sources associating them with FASTK)

Utopia: connect your pdf to the dynamic
world of online information

Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis. (PubMed id 7544399)^{1, 2, 3, 9} Tian Q.... Anderson P. (1995)
FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression. (PubMed id 15572676)^{1, 3, 9} Li W....Anderson P. (2004)
Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing. (PubMed id 17135269)^{1, 2} Izquierdo J.M. and Valcarcel J. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing. (PubMed id 17592127)^{1, 9} Simarro M....Anderson P. (2007)
FAST is a BCL-X(L)-associated mitochondrial protein. (PubMed id 15110758)^{1, 9} Li W....Anderson P. (2004)
Fas-activated serine/threonine phosphoprotein promote s immune-mediated pulmonary inflammation. (PubMed id 20363972)¹ Simarro M....Anderson P. (2010)
Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)¹ Hendrickson S.L....O'Brien S.J. (2010)
A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)¹ de Krom M....van Ree J.M. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10922	HGNC: 24676	AceView: FASTKandC7orf21	Ensembl:ENSG00000164896	euGenes: HUgn10922
ECgene: FASTK	H-InvDB: FASTK

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FASTK	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FASTK gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for FASTK gene:
Search GeneIP for patents involving FASTK

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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