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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FASTK Gene

protein-coding   GIFtS: 56
GCID: GC07M150773

Fas-activated serine/threonine kinase
 Explore 13 diseases affiliated with
FASTK via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FASTK    

Aliases
for FASTK gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Fas-Activated Serine/Threonine Kinase1 2
FAST1 2 5
FAST Kinase2 3
EC 2.7.11.83

External Ids:    HGNC: 246761   Entrez Gene: 109222   Ensembl: ENSG000001648967   OMIM: 6069655   UniProtKB: Q142963   

Export aliases for FASTK gene to outside databases

Previous GC identifers: GC07M149020 GC07M150088 GC07M150165 GC07M150211 GC07M150404 GC07M144586


Summaries
for FASTK gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FASTK:
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be
activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it
phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of
lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other
variants exist, but their full-length natures have not yet been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FASTK_HUMAN, Q14296
Function: Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an
mRNA encoding a pro-apoptotic form of the receptor

Gene Wiki entry for FASTK


Genomic Views
for FASTK gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007914.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FASTK gene promoter:
         GR   p53   GR-beta   GR-alpha   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FASTK promoter sequence
   Search SABiosciences Chromatin IP Primers for FASTK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FASTK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q35   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q35

FASTK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FASTK gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M150773:  view genomic region     (about GC identifiers)

Start:
 150,773,679 bp from pter      End:
 150,777,953 bp from pter
Size:
 4,275 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 150,103,248-150,107,491     

Proteins
for FASTK gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FASTK_HUMAN, Q14296 (See protein sequence)
Recommended Name: Fas-activated serine/threonine kinase  
Size: 549 amino acids; 61104 Da
Subunit: Interacts with TIA-1 and TIAR
Sequence caution: Sequence=BAD93020.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8K867 F8VTW9 Q59EM8 Q8IVA0
Alternative splicing: 3 isoforms:  Q14296-1   Q14296-2   Q14296-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FASTK: NX_Q14296

Post-translational modifications:

  • Autophosphorylated on serine/threonine residues. Activated by dephosphorylation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14296

    • FASTK Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001245390.1  NP_006703.1  NP_148936.2  

    ENSEMBL proteins: 
     ENSP00000418781   ENSP00000324817   ENSP00000297532   ENSP00000418516   ENSP00000444498  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: FASTK
    OriGene Protein Over-expression Lysate (see all 2): FASTK
    OriGene Custom Protein Services for FASTK 
    GenScript Custom Purified and Recombinant Proteins Services for FASTK
    Novus Biologicals FASTK Proteins
    Novus Biologicals FASTK Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FASTK

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--


    FASTK for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for FASTK

    Protein Domains /
    Families
    for FASTK gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FASTK for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR010622 FAST_Leu-rich
     IPR013584 RAP
     IPR013579 FAST_2
     IPR015715 Ser/Thr_kinase_FAST

    Graphical View of Domain Structure for InterPro Entry Q14296

    ProtoNet protein and cluster: Q14296

    2 Blocks protein families:
    IPB013579 FAST kinase-like protein
    IPB013584 RAP domain


    UniProtKB/Swiss-Prot: FASTK_HUMAN, Q14296
    Similarity: Belongs to the FAST protein kinase family
    Similarity: Contains 1 RAP domain


    Function
    for FASTK gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FASTK_HUMAN, Q14296
    Function: Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an
    mRNA encoding a pro-apoptotic form of the receptor
    Catalytic activity: ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine
    phosphoprotein]

    Enzyme Number (IUBMB): EC 2.7.11.81

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FASTK
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    hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-miR-93 hsa-miR-520g hsa-miR-526b* hsa-miR-17 hsa-miR-130b
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    Inhib. RNA
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    OriGene shRNA RFP: FASTK
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FASTK

    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FASTK 

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    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA7544399
    GO:0005515protein binding IPI7544399
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----


    FASTK for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Fastktm1.1Andp for FASTK
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Fastk):
     hematopoietic system  homeostasis/metabolism  immune system 

    FASTK for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FASTK gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FASTK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/9 Interacting proteins for FASTK (Q142963 ENSP000002975324) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBPMSQ930623, ENSP000003401764I2D: score=3 STRING: ENSP00000340176
    CRKP461083, ENSP000003005744I2D: score=2 STRING: ENSP00000300574
    TIA1P314833, ENSP000004013714I2D: score=2 STRING: ENSP00000401371
    CALCOCO2Q131373, ENSP000002589474I2D: score=3 STRING: ENSP00000258947
    MDFIQ997503, ENSP000002303214I2D: score=3 STRING: ENSP00000230321
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA7544399
    GO:0006915apoptotic process ----
    GO:0043484regulation of RNA splicing IMP17592127
    GO:0097190apoptotic signaling pathway TAS7544399


    FASTK for ontologies           About GeneDecksing



    Drugs & Compounds
    for FASTK gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FASTK for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FASTK

    2 HMDB Compounds for FASTK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    2 Novoseek chemical compound relationships for FASTK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 58.8 8 17592127 (2), 7544399 (2), 18649053 (1), 15110758 (1) (see all 5)
    serine 46.8 8 17592127 (2), 7544399 (2), 18649053 (1), 15110758 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about FASTK 

    Transcripts
    for FASTK gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FASTK gene (3 alternative transcripts): 
    NM_001258461.1  NM_006712.4  NM_033015.3  

    Unigene Cluster for FASTK:

    Fas-activated serine/threonine kinase
    Hs.647094  [show with all ESTs]
    Unigene Representative Sequence: NM_006712
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483105 ENST00000489884(uc003wiw.1) ENST00000465272 ENST00000467237
    ENST00000353841 ENST00000297532(uc003wix.1) ENST00000482571(uc003wiz.1)
    ENST00000460980(uc003wiy.1) ENST00000469237 ENST00000482806 ENST00000483953
    ENST00000466855 ENST00000459800 ENST00000478477 ENST00000461979 ENST00000478883
    ENST00000496663 ENST00000540185(uc003wja.1)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FASTK
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate FASTK (see all 21):
    hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-miR-93 hsa-miR-520g hsa-miR-526b* hsa-miR-17 hsa-miR-130b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FASTK (see all 7)
    OriGene shRNA RFP: FASTK
    OriGene siRNA: FASTK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FASTK
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FASTK
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FASTK

    Additional cDNA sequence: 

    AB209783.1 AK223132.1 AK292232.1 BC000377.2 BC006386.2 BC011770.2 BC039026.2 X86779.1 

    24/31 DOTS entries (see all 31):

    DT.449627  DT.75139864  DT.100887325  DT.100887336  DT.100887331  DT.100887324  DT.100887321  DT.91642064 
    DT.100887320  DT.98131849  DT.91880944  DT.121074452  DT.97855030  DT.100887330  DT.97855032  DT.100887337 
    DT.100887316  DT.100887327  DT.100887339  DT.121074388  DT.121074427  DT.40115637  DT.100887333  DT.100887319 

    24/631 AceView cDNA sequences (see all 631):

    BM142075 BM844796 BQ223605 BC033182 CA405449 CR623848 BX410184 CR611266 
    BM052855 BM923936 BU166717 AW205490 BU508454 BX388146 BU622580 BM772679 
    AA877731 BM799420 F06007 BU190561 NM_031434 BQ217247 NM_006712 CR604089 

    GeneLoc Exon Structure

    5/19 Alternative Splicing Database (ASD) splice patterns (SP) for FASTK (see all 19)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^
    SP1:                          -     -                 -     -                                               -                                   -               
    SP2:                          -     -                 -     -           -     -                             -                                   -               
    SP3:                          -     -     -     -     -     -                                               -                                   -               
    SP4:                                      -     -     -     -           -     -                             -                                   -               
    SP5:                          -     -     -           -     -           -     -                                                                                 

    ExUns: 12a · 12b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for FASTK

    Expression
    for FASTK gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FASTK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGGGTGGAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FASTK expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartAtrioventricular CanalAtrioventricular Canal CellsMyocardium
    HeartOutflow TractHeart
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See FASTK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FASTK

    SOURCE GeneReport for Unigene cluster: Hs.647094

    UniProtKB/Swiss-Prot: FASTK_HUMAN, Q14296
    Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas

        SABiosciences Expression via Pathway-Focused PCR Array including FASTK: 
              Apoptosis 384HT in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for FASTK gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for FASTK gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia FASTK6
    		 --
    		 46(a)
    		 1 ↔ 1
    		 GL344454.1(21863-26728)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.132162 Transcribed sequence with weak similarity to protein more 75.62(n)    BI885083.1 


    ENSEMBL Gene Tree for FASTK (if available)
    TreeFam Gene Tree for FASTK (if available) 

    Paralogs
    for FASTK gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FASTK gene
    TBRG42  FASTKD12  FASTKD32  
    1 SIMAP similar gene for FASTK using alignment to 4 protein entries:     FASTK_HUMAN (see all proteins):
    DKFZp667F1810

    FASTK for paralogs           About GeneDecksing



    Genomic Variants
    for FASTK gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/79 NCBI SNPs in FASTK are shown (see all 79)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs23039431,2
    		C,F,H,--150104884(+) CTGCAC/AGTGAC 1 -- us2k119Minor allele frequency- A:0.03EA NS NA WA CSA 3022
    rs2019724781,2
    		C,--150774120(+) CTGCAG/TGGGGA 4 -- us2k1 int11Minor allele frequency- T:0.00EU 539
    rs2012309931,2
    		--150774121(+) TGCAGA/GGGGAG 4 -- us2k1 int10--------
    rs1390308651,2
    		C,--150774148(+) ATGGCA/GGGCAA 4 -- int1 us2k10--------
    rs1998757251,2
    		--150774197(+) GGGCAC/GGGTCT 7 P R mis1 us2k10--------
    rs1494263871,2
    		C,--150774283(+) CTCACA/GGGAAG 7 P syn1 us2k10--------
    rs22886481,2
    		C,F,H,--150774308(+) TGCTGG/ACGCAC 7 /A /V mis1 us2k1 ese324Minor allele frequency- A:0.07EA NS NA CSA WA EU 8329
    rs1402968041,2
    		C,--150774467(+) AACCCC/TTCAGC 7 E syn1 us2k11Minor allele frequency- T:0.00NA 4418
    rs1894546871,2
    		C,--150774997(+) GAAAAA/GACAAA 7 V us2k1 syn10--------
    rs777036621,2
    		C,--150775028(-) ACTGCA/GGTGCC 7 Q R us2k1 mis10--------

    HapMap Linkage Disequilibrium report for FASTK (150773679 - 150777953 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for FASTK
         2 CNVs: 52152 4574

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    Disorders / Diseases
    for FASTK gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FASTK for disorders           About GeneDecksing

    OMIM gene information: 606965    OMIM disorders: --

    13 diseases for FASTK:    About MalaCards
    vestibular nystagmus    occupational dermatitis    autism spectrum disorder    nystagmus
    atopy    hepatitis b    hyperglycemia    dermatitis
    asthma    adenoma    hepatitis    immunodeficiency
    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for FASTK:
    Occupational dermatitis     Vestibular nystagmus

    2 Novoseek disease relationships for FASTK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 2.93 1 16162475 (1)
    tumors 0 2 16162475 (1), 17695722 (1)

    Human Genome Epidemiology (HuGE) Navigator: FASTK (3 documents)

    Export disorders for FASTK gene to outside databases

    Publications
    for FASTK gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FASTK gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with FASTK)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis. (PubMed id 7544399)1, 2, 3, 9 Tian Q.... Anderson P. (1995)
    2. FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression. (PubMed id 15572676)1, 3, 9 Li W....Anderson P. (2004)
    3. Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing. (PubMed id 17135269)1, 2 Izquierdo J.M. and Valcarcel J. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing. (PubMed id 17592127)1, 9 Simarro M....Anderson P. (2007)
    7. FAST is a BCL-X(L)-associated mitochondrial protein. (PubMed id 15110758)1, 9 Li W....Anderson P. (2004)
    8. Fas-activated serine/threonine phosphoprotein promote s immune-mediated pulmonary inflammation. (PubMed id 20363972)1 Simarro M....Anderson P. (2010)
    9. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    10. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1 de Krom M....van Ree J.M. (2009)

    External Searches for FASTK gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FASTK gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10922 HGNC: 24676 AceView: FASTKandC7orf21 Ensembl:ENSG00000164896 euGenes: HUgn10922
    ECgene: FASTK H-InvDB: FASTK

    Other Databases showing FASTK gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FASTK gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FASTK Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FASTK gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FASTK gene:
    Search GeneIP for patents involving FASTK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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