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Aliases for FASN Gene

Aliases for FASN Gene

  • Fatty Acid Synthase 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 27X, Member 1 2 3
  • FAS 3 4
  • EC 2.3.1.85 4
  • EC 6.3.3.1 61
  • EC 2.3.1 61
  • SDR27X1 3
  • OA-519 3

External Ids for FASN Gene

Previous GeneCards Identifiers for FASN Gene

  • GC17M079459
  • GC17M9J0077
  • GC17M080572
  • GC17M077629
  • GC17M080037
  • GC17M075436

Summaries for FASN Gene

Entrez Gene Summary for FASN Gene

  • The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]

GeneCards Summary for FASN Gene

FASN (Fatty Acid Synthase) is a Protein Coding gene. Diseases associated with FASN include Obesity and Prostate Cancer. Among its related pathways are Regulation of cholesterol biosynthesis by SREBP (SREBF) and palmitate biosynthesis. GO annotations related to this gene include poly(A) RNA binding and identical protein binding. An important paralog of this gene is OXSM.

UniProtKB/Swiss-Prot for FASN Gene

  • Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.

Tocris Summary for FASN Gene

  • Fatty acid synthase (FASN), EC 2.3.1.85, is a multienzyme that catalyzes the conversion of acetyl-CoA and malonyl-CoA to the 16-carbon fatty acid palmitate. FASN overexpression and hyperactivity is commonly associated with malignant cells.

Gene Wiki entry for FASN Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FASN Gene

Genomics for FASN Gene

Regulatory Elements for FASN Gene

Enhancers for FASN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around FASN on UCSC Golden Path with GeneCards custom track

Promoters for FASN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FASN on UCSC Golden Path with GeneCards custom track

Genomic Location for FASN Gene

Chromosome:
17
Start:
82,078,333 bp from pter
End:
82,098,332 bp from pter
Size:
20,000 bases
Orientation:
Minus strand

Genomic View for FASN Gene

Genes around FASN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FASN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FASN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FASN Gene

Proteins for FASN Gene

  • Protein details for FASN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49327-FAS_HUMAN
    Recommended name:
    Fatty acid synthase
    Protein Accession:
    P49327
    Secondary Accessions:
    • Q13479
    • Q16702
    • Q4LE83
    • Q6P4U5
    • Q6SS02
    • Q969R1
    • Q96C68
    • Q96IT0

    Protein attributes for FASN Gene

    Size:
    2511 amino acids
    Molecular mass:
    273427 Da
    Quaternary structure:
    • Homodimer which is arranged in a head to tail fashion.
    Miscellaneous:
    • The relatively low beta-ketoacyl synthase activity may be attributable to the low 4-phosphopantetheine content of the protein.
    SequenceCaution:
    • Sequence=AAB35516.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAC50259.1; Type=Miscellaneous discrepancy; Note=Several sequencing errors.; Evidence={ECO:0000305}; Sequence=BAE06070.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FASN Gene

neXtProt entry for FASN Gene

Selected DME Specific Peptides for FASN Gene

Post-translational modifications for FASN Gene

  • Ubiquitination at Lys 41, Lys 213, Lys 257, Lys 326, Lys 631, Lys 992, Lys 1116, Lys 1142, Lys 1151, Lys 1158, Lys 1393, Lys 1495, Lys 1704, Lys 1739, Lys 1851, Lys 1866, Lys 1878, Lys 1911, Lys 1927, Lys 2438, and Lys 2449
  • Modification sites at PhosphoSitePlus

Other Protein References for FASN Gene

Antibody Products

  • R&D Systems Antibodies for FASN (Fatty Acid Synthase/FASN)
  • Cell Signaling Technology (CST) Antibodies for FASN (FASN)

Domains & Families for FASN Gene

Gene Families for FASN Gene

Suggested Antigen Peptide Sequences for FASN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49327

UniProtKB/Swiss-Prot:

FAS_HUMAN :
  • Contains 1 acyl carrier domain.
Domain:
  • Contains 1 acyl carrier domain.
genes like me logo Genes that share domains with FASN: view

Function for FASN Gene

Molecular function for FASN Gene

GENATLAS Biochemistry:
fatty acid ethyl ester synthase 1,NADPH dependent
UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + (n+1) CoA + n CO(2) + 2n NADP(+).
UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein].
UniProtKB/Swiss-Prot CatalyticActivity:
Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein].
UniProtKB/Swiss-Prot CatalyticActivity:
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH.
UniProtKB/Swiss-Prot CatalyticActivity:
A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
An acyl-[acyl-carrier protein] + NADP(+) = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH.
UniProtKB/Swiss-Prot CatalyticActivity:
Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl-carrier-protein] + oleate.
UniProtKB/Swiss-Prot Function:
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.

Enzyme Numbers (IUBMB) for FASN Gene

Gene Ontology (GO) - Molecular Function for FASN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004312 fatty acid synthase activity IEA,TAS --
GO:0004313 [acyl-carrier-protein] S-acetyltransferase activity IEA --
GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity IEA --
GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity IEA --
GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IEA --
genes like me logo Genes that share ontologies with FASN: view
genes like me logo Genes that share phenotypes with FASN: view

Animal Models for FASN Gene

MGI Knock Outs for FASN:

Animal Model Products

  • Taconic Biosciences Mouse Models for FASN

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FASN

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FASN Gene

Localization for FASN Gene

Subcellular locations from UniProtKB/Swiss-Prot for FASN Gene

Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FASN Gene COMPARTMENTS Subcellular localization image for FASN gene
Compartment Confidence
cytosol 5
extracellular 5
golgi apparatus 5
plasma membrane 5
mitochondrion 3
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for FASN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA --
GO:0005739 mitochondrion IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with FASN: view

Pathways & Interactions for FASN Gene

genes like me logo Genes that share pathways with FASN: view

SIGNOR curated interactions for FASN Gene

Is activated by:

Gene Ontology (GO) - Biological Process for FASN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IDA 16210410
GO:0006084 acetyl-CoA metabolic process IEA --
GO:0006631 fatty acid metabolic process TAS 7835891
GO:0006633 fatty acid biosynthetic process IEA --
GO:0015939 pantothenate metabolic process TAS --
genes like me logo Genes that share ontologies with FASN: view

Drugs & Compounds for FASN Gene

(71) Drugs for FASN Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Orlistat Approved, Investigational Pharma inhibitor, Target Lipase inhibitor for obesity treatment, Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 52
Cerulenin Approved Pharma Target, inhibitor 0
Isoniazid Approved Pharma 146
oleic acid Approved, Vet_approved Pharma Full agonist, Agonist 0
Carbon dioxide Approved, Vet_approved Pharma 0

(67) Additional Compounds for FASN Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
(R)-3-Hydroxydecanoic acid
(R)-3-Hydroxydodecanoic acid
(R)-3-Hydroxy-hexadecanoic acid

(2) Tocris Compounds for FASN Gene

Compound Action Cas Number
G 28UCM FASN inhibitor 1094451-90-7
GSK 2194069 Potent human fatty acid synthase (hFASN) inhibitor 1332331-08-4

(3) ApexBio Compounds for FASN Gene

Compound Action Cas Number
C 75 Fatty acid synthase (FAS) inhibitor 191282-48-1
GSK2194069 human fatty acid synthase inhibitor 1332331-08-4
Isoniazid 54-85-3
genes like me logo Genes that share compounds with FASN: view

Drug Products

Transcripts for FASN Gene

Unigene Clusters for FASN Gene

Fatty acid synthase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FASN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FASN Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36 ^ 37a · 37b · 37c ^ 38 ^ 39a · 39b · 39c ^ 40a · 40b · 40c ^ 41 ^ 42 ^
SP1:
SP2: - - - - -
SP3:
SP4: -
SP5: - - - - - - -
SP6:

ExUns: 43a · 43b · 43c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for FASN Gene

GeneLoc Exon Structure for
FASN
ECgene alternative splicing isoforms for
FASN

Expression for FASN Gene

mRNA expression in normal human tissues for FASN Gene

mRNA differential expression in normal tissues according to GTEx for FASN Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x8.9), Adipose - Subcutaneous (x6.9), and Breast - Mammary Tissue (x4.9).

Protein differential expression in normal tissues from HIPED for FASN Gene

This gene is overexpressed in Milk (12.0), Liver (8.2), and Breast (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FASN Gene



Protein tissue co-expression partners for FASN Gene

NURSA nuclear receptor signaling pathways regulating expression of FASN Gene:

FASN

SOURCE GeneReport for Unigene cluster for FASN Gene:

Hs.83190

mRNA Expression by UniProt/SwissProt for FASN Gene:

P49327-FAS_HUMAN
Tissue specificity: Ubiquitous. Prominent expression in brain, lung, and liver.
genes like me logo Genes that share expression patterns with FASN: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FASN Gene

Orthologs for FASN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FASN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FASN 35
  • 99 (a)
OneToOne
FASN 34
  • 98.79 (n)
  • 98.79 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia FASN 35
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fasn 35
  • 82 (a)
OneToOne
Fasn 16
Fasn 34
  • 80.91 (n)
  • 81.61 (a)
oppossum
(Monodelphis domestica)
Mammalia FASN 35
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FASN 35
  • 80 (a)
OneToOne
FASN 34
  • 83.25 (n)
  • 81.7 (a)
cow
(Bos Taurus)
Mammalia FASN 35
  • 80 (a)
OneToOne
FASN 34
  • 81.78 (n)
  • 79.47 (a)
rat
(Rattus norvegicus)
Mammalia Fasn 34
  • 80.63 (n)
  • 82.33 (a)
chicken
(Gallus gallus)
Aves FASN 35
  • 57 (a)
OneToOne
FASN 34
  • 64.78 (n)
  • 66.4 (a)
lizard
(Anolis carolinensis)
Reptilia FASN 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fasn 34
  • 62.57 (n)
  • 64.7 (a)
zebrafish
(Danio rerio)
Actinopterygii fasn 35
  • 64 (a)
OneToMany
fasn 35
  • 64 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta v(2)k05816 35
  • 43 (a)
OneToMany
CG3523 35
  • 42 (a)
OneToMany
CG17374 35
  • 37 (a)
OneToMany
v(2)k05816 34
  • 54.54 (n)
  • 46.96 (a)
v(2)k05816 36
  • 45 (a)
CG17374 36
  • 39 (a)
BcDNA:GH07626 36
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea fasn-1 35
  • 40 (a)
OneToMany
F32H2.6 35
  • 33 (a)
OneToMany
fasn-1 34
  • 49.54 (n)
  • 44.08 (a)
F32H2.5 36
  • 41 (a)
C41A3.1 36
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CEM1 35
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
OneToOne
Species where no ortholog for FASN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FASN Gene

ENSEMBL:
Gene Tree for FASN (if available)
TreeFam:
Gene Tree for FASN (if available)

Paralogs for FASN Gene

Paralogs for FASN Gene

genes like me logo Genes that share paralogs with FASN: view

Variants for FASN Gene

Sequence variations from dbSNP and Humsavar for FASN Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2228305 - 82,084,916(-) CCCAC(A/G)TCCCG reference, missense
rs561903908 - 82,083,992(+) AGACG(C/T)GGCAG reference, missense
rs2228307 - 82,083,019(-) GCTAC(A/G)TCATC reference, missense
rs15324 -- 82,078,483(-) TTGTT(C/T)TTCAA utr-variant-3-prime
rs1140606 -- 82,096,417(-) CATGT(C/T)CGGGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FASN Gene

Variant ID Type Subtype PubMed ID
dgv5801n54 CNV loss 21841781
esv1000741 CNV deletion 20482838
esv21913 CNV gain+loss 19812545
esv2666752 CNV deletion 23128226
esv2716470 CNV deletion 23290073
esv2716471 CNV deletion 23290073
nsv1055241 CNV loss 25217958
nsv1121945 CNV deletion 24896259
nsv428351 CNV gain 18775914
nsv457975 CNV loss 19166990
nsv457976 CNV gain 19166990
nsv470621 CNV gain 18288195
nsv576183 CNV loss 21841781
nsv576187 CNV gain 21841781
nsv952393 CNV deletion 24416366

Variation tolerance for FASN Gene

Residual Variation Intolerance Score: 1.84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.91; 74.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FASN Gene

Human Gene Mutation Database (HGMD)
FASN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FASN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FASN Gene

Disorders for FASN Gene

MalaCards: The human disease database

(4) MalaCards diseases for FASN Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
obesity
  • obesity, association with
prostate cancer
  • prostate cancer, hereditary, 5
colorectal cancer
  • colorectal cancer, somatic
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search FASN in MalaCards View complete list of genes associated with diseases

Relevant External Links for FASN

Genetic Association Database (GAD)
FASN
Human Genome Epidemiology (HuGE) Navigator
FASN
Tumor Gene Database (TGDB):
FASN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FASN
genes like me logo Genes that share disorders with FASN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FASN Gene

Publications for FASN Gene

  1. Human fatty acid synthase: properties and molecular cloning. (PMID: 7567999) Jayakumar A. … Wakil S.J. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 22 65
  2. Effect of genetic variation in the human fatty acid synthase gene (FASN) on obesity and fat depot-specific mRNA expression. (PMID: 19876008) Schleinitz D. … Kovacs P. (Obesity (Silver Spring) 2010) 3 22 46 65
  3. Val1483Ile in FASN gene is linked to central obesity and insulin sensitivity in adult white men. (PMID: 19300427) Moreno-Navarrete J.M. … FernA!ndez-Real J.M. (Obesity (Silver Spring) 2009) 3 22 46 65
  4. Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk. (PMID: 19252981) Campa D. … Kaaks R. (Breast Cancer Res. Treat. 2009) 3 22 46 65
  5. Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat. (PMID: 17618296) Pemble C.W. IV … Lowther W.T. (Nat. Struct. Mol. Biol. 2007) 3 4 22 65

Products for FASN Gene

Sources for FASN Gene

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