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FASN Gene

protein-coding   GIFtS: 75
GCID: GC17M080037

Fatty Acid Synthase

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fatty Acid Synthase1 2     SDR27X12
FAS2 3     Short Chain Dehydrogenase/Reductase Family 27X, Member 12
Member 11     EC 2.3.1.853
Short Chain Dehydrogenase/Reductase Family 27X1     EC 2.3.18
OA-5192     EC 6.3.3.18

External Ids:    HGNC: 35941   Entrez Gene: 21942   Ensembl: ENSG000001697107   OMIM: 6002125   UniProtKB: P493273   

Export aliases for FASN gene to outside databases

Previous GC identifers: GC17M079459 GC17M9J0077 GC17M080572 GC17M077629 GC17M075436


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FASN Gene:
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of
palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In
some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which
the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. (provided by RefSeq, Jul 2008)

GeneCards Summary for FASN Gene:
FASN (fatty acid synthase) is a protein-coding gene. Diseases associated with FASN include hypobetalipoproteinemia, and breast disease. GO annotations related to this gene include protein homodimerization activity and NADPH binding. An important paralog of this gene is OXSM.

UniProtKB/Swiss-Prot: FAS_HUMAN, P49327
Function: Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and
NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein

Gene Wiki entry for FASN (Fatty acid synthase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010663.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the FASN gene promoter:
         PPAR-alpha   PPAR-gamma1   PPAR-gamma2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): FASN promoter sequence
   Search Chromatin IP Primers for FASN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FASN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25

FASN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FASN gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M080037:  view genomic region     (about GC identifiers)

Start:
80,036,214 bp from pter      End:
80,056,208 bp from pter
Size:
19,995 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FAS_HUMAN, P49327 (See protein sequence)
Recommended Name: Fatty acid synthase  
Size: 2511 amino acids; 273427 Da
Subunit: Homodimer which is arranged in a head to tail fashion
Miscellaneous: The relatively low beta-ketoacyl synthase activity may be attributable to the low
4'-phosphopantetheine content of the protein
Sequence caution: Sequence=AAB35516.1; Type=Erroneous initiation; Sequence=AAC50259.1; Type=Miscellaneous
discrepancy; Note=Several sequencing errors; Sequence=BAE06070.1; Type=Erroneous initiation;
Selected PDB 3D structures from and Proteopedia for FASN (see all 7):
1XKT (3D)        2CG5 (3D)        2JFD (3D)        2JFK (3D)        2PX6 (3D)        3HHD (3D)    
Secondary accessions: Q13479 Q16702 Q4LE83 Q6P4U5 Q6SS02 Q969R1 Q96C68 Q96IT0

Explore the universe of human proteins at neXtProt for FASN: NX_P49327

Explore proteomics data for FASN at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys41, Lys70, Lys213, Lys257, Lys298, Lys326, Lys436, Lys528, Lys631, Lys992,
                                 Lys1072, Lys1116, Lys1142, Lys1151, Lys1158, Lys1239, Lys1393, Lys1429, Lys1495, Lys1591 (see all 30)
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for FASN (P49327)
     NSFGFGG  GGLGGFG  DTACSSS  YIEAHGTGT 


    See FASN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004095.4  
    ENSEMBL proteins: 
     ENSP00000304592   ENSP00000462949  
    Reactome Protein details: P49327

    FASN Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene MassSpec for FASN
    OriGene Custom Protein Services for FASN
    GenScript Custom Purified and Recombinant Proteins Services for FASN
    Novus Biologicals FASN Proteins
    Novus Biologicals FASN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FASN

    FASN Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for FASN (Fatty Acid Synthase/FASN)
    Cell Signaling Technology (CST) Antibodies for FASN 
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    Novus Biologicals FASN Antibodies
    Abcam antibodies for FASN
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    ThermoFisher Antibody for FASN
    LSBio Antibodies in human, mouse, rat for FASN

    FASN Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FASN
    Cloud-Clone Corp. CLIAs for FASN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SDRA: Short chain dehydrogenase/reductase superfamily / Atypical members

    Selected InterPro protein domains (see all 20):
     IPR016035 Acyl_Trfase/lysoPLipase
     IPR013149 ADH_C
     IPR016038 Thiolase-like_subgr
     IPR011032 GroES-like
     IPR020843 PKS_ER

    Graphical View of Domain Structure for InterPro Entry P49327

    ProtoNet protein and cluster: P49327

    5 Blocks protein domains:
    IPB000794 Beta-ketoacyl synthase
    IPB001031 Thioesterase
    IPB001227 Acyl transferase domain
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB006162 Phosphopantetheine attachment site


    UniProtKB/Swiss-Prot: FAS_HUMAN, P49327
    Similarity: Contains 1 acyl carrier domain


    FASN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FAS_HUMAN, P49327
    Function: Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and
    NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein
    Catalytic activity: Acetyl-CoA + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + (n+1) CoA + n CO(2) + 2n
    NADP(+)
    Catalytic activity: Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein]
    Catalytic activity: Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein]
    Catalytic activity: Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] =
    3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein]
    Catalytic activity: (3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH
    Catalytic activity: A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H(2)O
    Catalytic activity: An acyl-[acyl-carrier protein] + NADP(+) = a trans-2,3-dehydroacyl-[acyl-carrier protein] +
    NADPH
    Catalytic activity: Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl-carrier-protein] + oleate

         Genatlas biochemistry entry for FASN:
    fatty acid ethyl ester synthase 1,NADPH dependent

         Enzyme Numbers (IUBMB): EC 2.3.1.851 EC 6.3.3.12 EC 2.3.12

         Gene Ontology (GO): Selected molecular function terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004312fatty acid synthase activity TAS--
    GO:0004313[acyl-carrier-protein] S-acetyltransferase activity IEA--
    GO:0004314[acyl-carrier-protein] S-malonyltransferase activity IEA--
    GO:00043153-oxoacyl-[acyl-carrier-protein] synthase activity IEA--
         
    FASN for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FASN:
     Increased cell death in HCC-19  Synthetic lethal with c-Myc af 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Fasn):
     adipose tissue  behavior/neurological  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 
     liver/biliary system  mortality/aging  nervous system 

    FASN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FASN: Fasntm1.1Sem Fasntm1Schi

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FASN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FASN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FASN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FASN

    miRNA
    Products:
        
    miRTarBase miRNAs that target FASN:
    hsa-mir-877-3p (MIRT036832), hsa-mir-2110 (MIRT035759), hsa-mir-10b-5p (MIRT047454), hsa-mir-744-5p (MIRT037647), hsa-mir-942-5p (MIRT036557), hsa-mir-93-5p (MIRT048815), hsa-mir-1303 (MIRT035891), hsa-mir-197-3p (MIRT048070), hsa-mir-92b-3p (MIRT040657), hsa-mir-326 (MIRT043627), hsa-mir-331-3p (MIRT043370), hsa-mir-27b-3p (MIRT046177), hsa-mir-92a-3p (MIRT049363), hsa-mir-193b-3p (MIRT041353), hsa-mir-26a-5p (MIRT050182), hsa-mir-17-5p (MIRT050921), hsa-mir-423-3p (MIRT042639), hsa-mir-10a-5p (MIRT047715), hsa-mir-222-3p (MIRT046667), hsa-mir-615-3p (MIRT039824), hsa-mir-15a-5p (MIRT051341), hsa-mir-1268a (MIRT035847), hsa-mir-324-3p (MIRT042890), hsa-mir-130b-5p (MIRT038318), hsa-mir-484 (MIRT041844), hsa-mir-186-5p (MIRT044920)

    Block miRNA regulation of human, mouse, rat FASN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FASN (see all 16):
    hsa-miR-607 hsa-miR-15a hsa-miR-1224-3p hsa-miR-1260b hsa-miR-103a hsa-miR-424 hsa-miR-3662 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidFASN 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FASN
    Predesigned siRNA for gene silencing in human, mouse, rat FASN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FASN

    Clone
    Products:
         
    OriGene clones in human, mouse for FASN (see all 6)
    OriGene ORF clones in mouse, rat for FASN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FASN (NM_004104)
    Sino Biological Human cDNA Clone for FASN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FASN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FASN

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for FASN 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FASN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FAS_HUMAN, P49327: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from
    stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    golgi apparatus4
    plasma membrane4
    nucleus3
    peroxisome3
    extracellular2
    mitochondrion2
    chloroplast1
    cytoskeleton1
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0005794Golgi apparatus IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA--

    FASN for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FASN About   (see all 15)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)0.75
    SREBP signalling0.31
    Activation of Gene Expression by SREBP (SREBF)0.75
    2Fatty acid metabolism
    Fatty acid metabolism0.42
    Fatty acid biosynthesis0.00
    Saturated fatty acid biosynthesis0.00
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    4Defective BTD causes biotidinase deficiency
    Defective BTD causes biotidinase deficiency1.00
    Metabolism of vitamins and cofactors1.00
    Defective AMN causes hereditary megaloblastic anemia 11.00
    Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC1.00
    Defective MMAA causes methylmalonic aciduria type cblA1.00
    Defective MUT causes methylmalonic aciduria mut type1.00
    Defective CD320 causes methylmalonic aciduria1.00
    Defects in cobalamin (B12) metabolism1.00
    5Integration of energy metabolism
    Integration of energy metabolism0.75
    ChREBP activates metabolic gene expression0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for FASN
        AMPK Enzyme Complex Pathway

    1 Cell Signaling Technology (CST) Pathway for FASN
        Glucose / Energy Metabolism

    1 GeneGo (Thomson Reuters) Pathway for FASN
        Saturated fatty acid biosynthesis

    Selected BioSystems Pathways for FASN (see all 6)
        AMPK signaling
    SREBP signalling
    SREBF and miR33 in cholesterol and lipid homeostasis
    Fatty Acid Biosynthesis
    fatty acid biosynthesis initiation II


    4 Reactome Pathways for FASN
        ChREBP activates metabolic gene expression
    Vitamin B5 (pantothenate) metabolism
    Activation of gene expression by SREBF (SREBP)
    Fatty Acyl-CoA Biosynthesis


    4 Kegg Pathways  (Kegg details for FASN):
        Fatty acid biosynthesis
    Metabolic pathways
    Fatty acid metabolism
    Insulin signaling pathway


    FASN for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FASN (see all 8): 
              Insulin Signaling Pathway in human mouse rat
              Fatty Acid Metabolism in human mouse rat
              Insulin Resistance in human mouse rat
              Prostate Cancer in human mouse rat
              Hepatotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FASN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FASN (P493271, 2, 3 ENSP000003045924) via UniProtKB, MINT, STRING, and/or I2D (see all 917)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSP90AB1P082382, 3MINT-7945693 MINT-72654 MINT-7947479 I2D: score=3 
    PRKDCP785272, 3, ENSP000003134204MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000313420
    MAP3K3Q997592, 3MINT-48440 MINT-48461 I2D: score=2 
    NSFP464592, 3MINT-7945693 MINT-7947479 I2D: score=1 
    PARP1P098742, 3, ENSP000003557594MINT-7947479 I2D: score=1 STRING: ENSP00000355759
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006084acetyl-CoA metabolic process IEA--
    GO:0006112energy reserve metabolic process TAS--
    GO:0006631fatty acid metabolic process TAS7835891
    GO:0006633fatty acid biosynthetic process IEA--
    GO:0006766vitamin metabolic process TAS--

    FASN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for FASN
      Browse compounds at ApexBio 

    Browse Tocris compounds for FASN (FAS)

    Selected HMDB Compounds for FASN (see all 32)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (R)-3-Hydroxy-Octadecanoic acid ----
    (R)-3-Hydroxy-hexadecanoic acid ----
    (R)-3-Hydroxy-tetradecanoic acid ----
    (R)-3-Hydroxydecanoic acid ----
    (R)-3-Hydroxydodecanoic acid ----
    (R)-3-Hydroxyoctanoic acid ----
    3-Oxodecanoic acid ----
    3-Oxododecanoic acid3-Oxo-Dodecanoic acid (see all 4)----
    3-Oxohexadecanoic acid3-Oxo-hexadecanoic acid (see all 4)----
    3-Oxotetradecanoic acid3-Oxo-tetradecanoic acid (see all 4)----

    2 DrugBank Compounds for FASN    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cerulenin-- 17397-89-6targetinhibitor17168665 11245456 12181752 11752352 20373869 10102370 15878185
    Orlistat(-)-Tetrahydrolipstatin (see all 4)96829-58-2targetinhibitor16749788 15870086 16091048 11752352 15026345 15138278

    Selected Novoseek inferred chemical compound relationships for FASN gene (see all 105)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cerulenin 94.6 37 15583825 (2), 9593836 (2), 9494573 (1), 17343199 (1) (see all 26)
    fatty acid 94.3 1614 15920554 (9), 18639282 (7), 15751987 (6), 18555493 (6) (see all 99)
    acetyl-coa 88.8 126 12213084 (4), 18760332 (2), 8944144 (2), 12759350 (2) (see all 87)
    sterol 85.3 100 16603153 (2), 20067991 (2), 8605019 (2), 7592729 (2) (see all 64)
    4'-phosphopantetheine 79 5 12815048 (1), 10206962 (1), 9405069 (1), 2318831 (1) (see all 5)
    thiolactomycin 78.2 5 12926927 (2), 17242430 (1), 1510554 (1)
    orlistat 75.2 15 18343106 (2), 17012255 (2), 18770866 (1), 16749788 (1) (see all 11)
    palmitate 72.4 36 19782152 (2), 8022791 (2), 9485400 (2), 18796435 (2) (see all 21)
    lipid 67.6 72 12646257 (2), 16048908 (1), 17413110 (1), 16788566 (1) (see all 53)
    3-hydroxy-3-methylglutaryl-coa 67.3 19 8999918 (2), 8833906 (1), 11323427 (1), 12754279 (1) (see all 10)



    FASN for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FASN gene: 
    NM_004104.4  

    Unigene Cluster for FASN:

    Fatty acid synthase
    Hs.83190  [show with all ESTs]
    Unigene Representative Sequence: NM_004104
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306749(uc002kdu.3 uc002kdv.1 uc002kdw.1) ENST00000584610
    ENST00000580382 ENST00000579758 ENST00000578424 ENST00000579410
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FASN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FASN (see all 16):
    hsa-miR-607 hsa-miR-15a hsa-miR-1224-3p hsa-miR-1260b hsa-miR-103a hsa-miR-424 hsa-miR-3662 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidFASN 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FASN
    Predesigned siRNA for gene silencing in human, mouse, rat FASN
    Clone
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    OriGene clones in human, mouse for FASN (see all 6)
    OriGene ORF clones in mouse, rat for FASN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FASN (NM_004104)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FASN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FASN
    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat FASN

    Additional mRNA sequence: 

    AB209988.1 AY451392.1 BC007267.1 BC007305.2 BC007909.1 BC014631.2 BC014634.2 BC021544.2 
    BC063242.1 S80437.1 U29344.1 

    Selected DOTS entries (see all 32):

    DT.100059743  DT.448160  DT.95110371  DT.100688445  DT.91871472  DT.100059746  DT.120978580  DT.120978656 
    DT.100648786  DT.100835114  DT.95110373  DT.120889547  DT.120978629  DT.120873367  DT.120978595  DT.120978641 
    DT.97821899  DT.100648788  DT.100773814  DT.120978591  DT.120978593  DT.75170060  DT.91780266  DT.95110370 

    Selected AceView cDNA sequences (see all 885):

    BC063242 BQ446147 AW613590 AI288580 AI951087 BM480368 BE221247 BQ071420 
    BU176734 BQ684267 BU190203 BG819866 BM802396 BQ924717 BU170968 BQ891897 
    BU173503 BG698013 BQ638490 BQ184277 BM550394 BE408801 AL134848 BI093509 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FASN (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36 ^ 37a · 37b · 37c ^ 38 ^ 39a · 39b · 39c ^ 40a · 40b · 40c ^ 41 ^ 42 ^
    SP1:                                                                                                                                                            
    SP2:                                                        -     -     -     -     -                                                                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                -                           
    SP5:                                                                                                  -     -     -     -     -     -     -                     

    ExUns: 43a · 43b · 43c
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for FASN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    FASN expression in normal human tissues (normalized intensities)      FASN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATCTCCAA
    FASN Expression
    About this image


    FASN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Thymus (Hematopoietic System)
             Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    FASN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FASN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.83190

    UniProtKB/Swiss-Prot: FAS_HUMAN, P49327
    Tissue specificity: Ubiquitous. Prominent expression in brain, lung, and liver

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FASN (see all 8): 
              Insulin Signaling Pathway in human mouse rat
              Fatty Acid Metabolism in human mouse rat
              Insulin Resistance in human mouse rat
              Prostate Cancer in human mouse rat
              Hepatotoxicity in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat FASN
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FASN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FASN gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fasn1 , 5 fatty acid synthase1, 5 80.91(n)1
    81.61(a)1
      11 (84.56 cM)5
    141041  NM_007988.31  NP_032014.31 
     1208059405 
    chicken
    (Gallus gallus)
    Aves FASN1 fatty acid synthase 64.78(n)
    66.4(a)
      396061  NM_205155.2  NP_990486.2 
    lizard
    (Anolis carolinensis)
    Reptilia FASN6
    fatty acid synthase
    65(a)
    1 ↔ 1
    2(118071977-118120473)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fasn1 fatty acid synthase 62.57(n)
    64.7(a)
      100487052  XM_002937311.2  XP_002937357.2 
    zebrafish
    (Danio rerio)
    Actinopterygii BI474038.12   -- 73.6(n)    BI474038.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:GH076263
    v(2)k058161
    fatty-acid synthase3
    v(2)k058161
    48(a)
    (best of 3)3
    54.54(n)1
    46.96(a)1
      23D13
    1173611  NM_139356.11  NP_647613.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F32H2.53
    fasn-11
    fatty acid synthase3
    fasn-11
    41(a)
    (best of 2)3
    49.54(n)1
    44.08(a)1
      I(8984016-8992830)3
    1727151  NM_060016.51  NP_492417.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CEM16
    Mitochondrial beta-keto-acyl synthase with possibl...
    21(a)
    1 → many
    V(278298-279626) YER061C


    ENSEMBL Gene Tree for FASN (if available)
    TreeFam Gene Tree for FASN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FASN gene
    OXSM2  

    FASN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for FASN (see all 1099)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs793818221,2
    F--80035748(+) CCAGCC/TTCCAC 1 -- ds50011Minor allele frequency- T:0.09WA 118
    rs178489561,2
    C,F--80035818(-) CACCAA/GGACGG 1 -- ds50018Minor allele frequency- G:0.18NA WA EA 368
    rs1827183261,2
    C--80035895(+) TCCACG/AAGGGG 1 -- ds50011Minor allele frequency- A:0.00EU 477
    rs1995618351,2
    C--80035987(+) CGGTA-/CCCCCC 1 -- ds50010--------
    rs572953901,2
    C--80035990(+) TACCCG/CCCCCC 1 -- ds50011Minor allele frequency- C:0.00NA 2
    rs178489541,2
    C--80036144(-) AGTCAC/TGGGGC 1 -- ds50010--------
    rs1116983671,2
    C--80036213(+) CGGTGG/TTGGAG 1 -- ds50010--------
    rs153241,2
    C,H--80036359(-) TTGTTT/CTTCAA 1 -- ut31 ese36Minor allele frequency- C:0.03MN NS EA NA 566
    rs1855550231,2
    --80036401(+) CCCGGC/TGCCGG 1 -- ut310--------
    rs1899692011,2
    --80036495(+) TCCTCA/GGGGAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FASN (80036214 - 80056208 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FASN (see all 32):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716471CNV Deletion23290073
    esv1000741CNV Deletion20482838
    esv2666752CNV Deletion23128226
    esv2716470CNV Deletion23290073
    dgv3353n71CNV Loss21882294
    nsv909188CNV Loss21882294
    nsv909186CNV Loss21882294
    dgv3341n71CNV Loss21882294
    dgv3333n71CNV Loss21882294
    dgv3340n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): FASN
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FASN
    DNA2.0 Custom Variant and Variant Library Synthesis for FASN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 600212    OMIM disorders: --

    Selected diseases for FASN (see all 78):    About MalaCards
    hypobetalipoproteinemia    breast disease    trophoblastic neoplasm    granular cell tumor
    fibromatosis    hyperinsulinism    fatty liver disease    hypertriglyceridemia
    uremia    glucose intolerance    traumatic brain injury    insulin resistance
    hyperthyroidism    brain injury    liposarcoma    gestational diabetes
    morbid obesity    endometrial carcinoma    obesity    endometrial adenocarcinoma

    5 diseases from the University of Copenhagen DISEASES database for FASN:
    Fatty liver disease     Diabetes mellitus     Prostate cancer     Breast cancer
    Hyperglycemia

    FASN for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Selected Novoseek inferred disease relationships for FASN gene (see all 58)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty liver 60.1 12 14642615 (3), 19929925 (2), 10549164 (1), 9629539 (1) (see all 7)
    obesity 56.9 35 19876008 (5), 15220220 (3), 19300427 (3), 16611078 (1) (see all 16)
    cancer 53.7 209 17168665 (7), 15607569 (6), 10716717 (4), 15533929 (3) (see all 99)
    microsatellite instability 52.2 6 19186181 (1), 19513025 (1), 19505918 (1), 19790197 (1) (see all 6)
    prostate cancer 52.2 67 17477363 (5), 18774944 (4), 18817351 (3), 15050917 (3) (see all 34)
    breast cancer 51.7 146 15870863 (7), 17786307 (6), 15583825 (5), 12531699 (5) (see all 54)
    breast carcinoma 49.6 23 8630954 (3), 11447743 (2), 8022791 (1), 10228495 (1) (see all 14)
    insulin resistance 46.3 6 18483661 (1), 19733654 (1), 19181734 (1)
    tumors 46.1 131 9191002 (5), 18796435 (4), 10705076 (3), 15897909 (3) (see all 66)
    carcinoma 37.7 27 15051923 (2), 20228782 (2), 9815604 (2), 11323104 (1) (see all 18)

    Genetic Association Database (GAD): FASN
    Human Genome Epidemiology (HuGE) Navigator: FASN (17 documents)
    Tumor Gene Database (TGDB): FASN

    Export disorders for FASN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FASN gene, integrated from 10 sources (see all 770):
    (articles sorted by number of sources associating them with FASN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human fatty acid synthase: properties and molecular cloning. (PubMed id 7567999)1, 2, 3, 9 Jayakumar A.... Wakil S.J. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    2. Effect of genetic variation in the human fatty acid synthase gene (FASN) on obesity and fat depot-specific mRNA expression. (PubMed id 19876008)1, 4, 9 Schleinitz D....Kovacs P. (Obesity (Silver Spring) 2010)
    3. Val1483Ile in FASN gene is linked to central obesity and insulin sensitivity in adult white men. (PubMed id 19300427)1, 4, 9 Moreno-Navarrete J.M....FernA!ndez-Real J.M. (Obesity (Silver Spring) 2009)
    4. Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk. (PubMed id 19252981)1, 4, 9 Campa D....Kaaks R. (Breast Cancer Res. Treat. 2009)
    5. Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain. (PubMed id 15507492)1, 2, 9 Chakravarty B.... Quiocho F.A. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    6. Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat. (PubMed id 17618296)1, 2, 9 Pemble C.W. IV... Lowther W.T. (Nat. Struct. Mol. Biol. 2007)
    7. Human fatty acid synthase mRNA: tissue distribution, genetic mapping, and kinetics of decay after glucose deprivation. (PubMed id 7595075)1, 2, 9 Semenkovich C.F.... Fiedorek F.T. Jr. (J. Lipid Res. 1995)
    8. Fatty acid synthesis: a potential selective target for antineoplastic therapy. (PubMed id 8022791)1, 2, 9 Kuhajda F.P.... Pasternack G.R. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    9. Genetic associations of brain structural networks in schizophrenia: a preliminary study. (PubMed id 20691427)1, 4 Jagannathan K....Pearlson G.D. (Biol. Psychiatry 2010)
    10. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2194 HGNC: 3594 AceView: FASN Ensembl:ENSG00000169710 euGenes: HUgn2194
    ECgene: FASN Kegg: 2194 H-InvDB: FASN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FASN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FASN Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FASN gene:
    Search GeneIP for patents involving FASN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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