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FASLG Gene

protein-coding   GIFtS: 67
GCID: GC01P172628

Fas Ligand (TNF Superfamily, Member 6)

(Previous names: tumor necrosis factor (ligand) superfamily, member 6)
(Previous symbols: APT1LG1, TNFSF6)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fas Ligand (TNF Superfamily, Member 6)1 2     CD95L2 3
APT1LG11 2 3 5     CD95 Ligand2 3
TNFSF61 2 3 5     ALPS1B2 5
FASL2 3 5     CD1782
Tumor Necrosis Factor (Ligand) Superfamily, Member 61 2     Apoptosis (APO-1) Antigen Ligand 12
Apoptosis Antigen Ligand2 3     Tumor Necrosis Factor Ligand Superfamily Member 62
Fas Antigen Ligand2 3     FasL3
APTL2 3     CD178 Antigen3
CD95-L2 3     Fas Ligand3

External Ids:    HGNC: 119361   Entrez Gene: 3562   Ensembl: ENSG000001175607   OMIM: 1346385   UniProtKB: P480233   

Export aliases for FASLG gene to outside databases

Previous GC identifers: GC01P169360 GC01P170894 GC01P143852


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FASLG Gene:
The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with
this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene
may be related to some cases of systemic lupus erythematosus (SLE). (provided by RefSeq, Jul 2008)

GeneCards Summary for FASLG Gene:
FASLG (Fas ligand (TNF superfamily, member 6)) is a protein-coding gene. Diseases associated with FASLG include lyell syndrome, and faslg-related autoimmune lymphoproliferative syndrome. GO annotations related to this gene include tumor necrosis factor receptor binding and receptor binding. An important paralog of this gene is TNFSF15.

UniProtKB/Swiss-Prot: TNFL6_HUMAN, P48023
Function: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be
involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may
have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or
both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects
Function: The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition

Gene Wiki entry for FASLG (Fas ligand) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the FASLG gene promoter:
         GR   Sp1   Meis-1b   FOXO1a   GR-alpha   Meis-1a   FOXO1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FASLG promoter sequence
   Search Chromatin IP Primers for FASLG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FASLG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23   Ensembl cytogenetic band:  1q24.3   HGNC cytogenetic band: 1q23

FASLG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FASLG gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P172628:  view genomic region     (about GC identifiers)

Start:
172,628,154 bp from pter      End:
172,636,014 bp from pter
Size:
7,861 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TNFL6_HUMAN, P48023 (See protein sequence)
Recommended Name: Tumor necrosis factor ligand superfamily member 6  
Size: 281 amino acids; 31485 Da
Subunit: Homotrimer (Probable). Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4,
EPS8L3, FGR, FYB, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1,
PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC,
SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1
2 PDB 3D structures from and Proteopedia for FASLG:
1BZI (3D)        4MSV (3D)    
Secondary accessions: Q9BZP9
Alternative splicing: 2 isoforms:  P48023-1   P48023-2   

Explore the universe of human proteins at neXtProt for FASLG: NX_P48023

Explore proteomics data for FASLG at MOPED

Post-translational modifications: 

  • The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form undergoes two
    successive intramembrane proteolytic cleavages. The first one is processed by ADAM10 producing an N-terminal
    fragment, which lacks the receptor-binding extracellular domain. This ADAM10-processed FasL (FasL APL) remnant
    form is still membrane anchored and further processed by SPPL2A that liberates the FasL intracellular domain
    (FasL ICD). FasL shedding by ADAM10 is a prerequisite for subsequent intramembrane cleavage by SPPL2A in T-cells1
  • N-glycosylated1
  • Phosphorylated by FGR on tyrosine residues; this is required for ubiquitination and subsequent internalization1
  • Monoubiquitinated1
  • Glycosylation2 at Asn184, Asn250, Asn260

  • See FASLG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000630.1  
    ENSEMBL proteins: 
     ENSP00000356694   ENSP00000344739  
    Reactome Protein details: P48023

    FASLG Human Recombinant Protein Products:

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    Novus Biologicals FASLG Lysates
    Sino Biological Recombinant Protein for FASLG
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for FASLG
    Browse Proteins at Cloud-Clone Corp.

    FASLG Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of FASLG
    R&D Systems Antibodies for FASLG (Fas Ligand/TNFSF6)
    Cell Signaling Technology (CST) Antibodies for FASLG  (FasL)
    OriGene Antibodies for FASLG
    OriGene Custom Antibody Services for FASLG
    Novus Biologicals FASLG Antibodies
    Abcam antibodies for FASLG
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for FASLG
    LSBio Antibodies in human, mouse, rat for FASLG

    FASLG Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for FASLG (Fas Ligand/TNFSF6)         (see all)
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    TNFSF: Tumor necrosis factor (ligand) superfamily
    ENDOLIG: Endogenous ligands

    5 InterPro protein domains:
     IPR021184 TNF_CS
     IPR006052 TNF_dom
     IPR006053 TNF
     IPR008983 Tumour_necrosis_fac-like_dom
     IPR028326 FASL

    Graphical View of Domain Structure for InterPro Entry P48023

    ProtoNet protein and cluster: P48023

    3 Blocks protein domains:
    IPB006052 Tumor Necrosis Factor
    IPB006053 Tumour necrosis factor family signature
    IPB008064 Fas antigen ligand signature


    UniProtKB/Swiss-Prot: TNFL6_HUMAN, P48023
    Similarity: Belongs to the tumor necrosis factor family


    FASLG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNFL6_HUMAN, P48023
    Function: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be
    involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may
    have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or
    both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects
    Function: The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS7826947
    GO:0005125cytokine activity IEA--
    GO:0005164tumor necrosis factor receptor binding IEA--
    GO:0005515protein binding IPI12198154
         
    FASLG for ontologies           About GeneDecksing


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 9 alleles(MGI details for Fasl) (see all 18):
     cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     nervous system  normal  renal/urinary system  reproductive system  respiratory system 

    FASLG for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FASLG: Fasltm1.1Bksa Fasltm1.1Lest

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FASLG
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FASLG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FASLG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FASLG

    miRNA
    Products:
        
    miRTarBase miRNAs that target FASLG:
    hsa-mir-21-5p (MIRT006989), hsa-mir-26b-5p (MIRT029780)

    Block miRNA regulation of human, mouse, rat FASLG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FASLG (see all 14):
    hsa-miR-98 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-3653 hsa-let-7i hsa-miR-21 hsa-let-7e
    SwitchGear 3'UTR luciferase reporter plasmidFASLG 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FASLG
    Predesigned siRNA for gene silencing in human, mouse, rat FASLG

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FASLG

    Clone
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    OriGene clones in human, mouse for FASLG (see all 8)
    OriGene ORF clones in mouse, rat for FASLG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FASLG (NM_000639)
    Sino Biological Human cDNA Clone for FASLG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FASLG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FASLG

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for FASLG 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FASLG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TNFL6_HUMAN, P48023: Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle lumen. Lysosome
    lumen. Note=Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and
    monoubiquitination. Colocalizes with the SPPL2A protease at the cell membrane
    TNFL6_HUMAN, P48023: Tumor necrosis factor ligand superfamily member 6, soluble form: Secreted (By similarity).
    Note=May be released into the extracellular fluid, probably by cleavage form the cell surface (By similarity)
    TNFL6_HUMAN, P48023: FasL intracellular domain: Nucleus. Note=The FasL ICD cytoplasmic form is translocated into
    the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    lysosome5
    nucleus5
    plasma membrane5
    vacuole5
    mitochondrion3
    cytoskeleton2
    cytosol2
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA18835034
    GO:0005634nucleus IDA17557115
    GO:0005887integral component of plasma membrane TAS7826947
    GO:0005901caveola IEA--

    FASLG for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FASLG About   (see all 39)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Allograft rejection
    Allograft rejection0.86
    Graft-versus-host disease0.65
    Allograft Rejection0.86
    Autoimmune thyroid disease0.61
    Type I diabetes mellitus0.69
    2TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    3Apoptosis and survival Caspase cascade
    Apoptosis and survival Caspase cascade0.44
    FAS pathway and Stress induction of HSP regulation0.44
    Apoptosis and survival FAS signaling cascades0.44
    4MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    5Apoptosis Signaling Pathways
    Apoptosis and survival Apoptotic TNF family pathways0.35
    Apoptosis Signaling Pathways0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 R&D Systems Pathways for FASLG
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
    Apoptosis Signaling Pathways
    IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FASLG (see all 31)
        Caspase Cascade
    14-3-3 Induced Apoptosis
    Endothelin-1 Signaling Pathway
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for FASLG
        Apoptosis and Autophagy
    Lymphocyte Signaling

    Selected GeneGo (Thomson Reuters) Pathways for FASLG (see all 10)
        Immune response Bacterial infections in normal airways
    Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades
    Signal transduction AKT signaling
    Transcription Role of VDR in regulation of genes involved in osteoporosis

    Selected BioSystems Pathways for FASLG (see all 15)
        MAPK signaling pathway
    Apoptosis
    Apoptosis Modulation and Signaling
    DNA damage response (only ATM dependent)
    FAS pathway and Stress induction of HSP regulation

    3 Sino Biological Pathways for FASLG
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway

    1 Reactome Pathway for FASLG
        FasL/ CD95L signaling


    Selected Kegg Pathways  (Kegg details for FASLG) (see all 21):
        MAPK signaling pathway
    Ras signaling pathway
    Cytokine-cytokine receptor interaction
    FoxO signaling pathway
    PI3K-Akt signaling pathway


    FASLG for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FASLG (see all 26): 
              Multiple Sclerosis in human mouse rat
              Cancer PathwayFinder in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Neurotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FASLG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FASLG (P480231, 2, 3 ENSP000003566944) via UniProtKB, MINT, STRING, and/or I2D (see all 138)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PACSIN2Q9UNF01, 2, 3, ENSP000002632464EBI-495538,EBI-742503 MINT-7136908 MINT-7137185 MINT-7137174 MINT-7136931 I2D: score=5 STRING: ENSP00000263246
    PACSIN3Q9UKS61, 2, 3, ENSP000002988384EBI-495538,EBI-77926 MINT-7137202 MINT-7136893 MINT-7137210 MINT-7136941 I2D: score=1 STRING: ENSP00000298838
    FADDQ131581, 2, 3, ENSP000003018384EBI-495538,EBI-494804 MINT-1956230 I2D: score=5 STRING: ENSP00000301838
    CASP8Q147901, 2, 3, ENSP000003512734EBI-495538,EBI-78060 MINT-1956272 I2D: score=4 STRING: ENSP00000351273
    SRGAP2O750441, 2, 3EBI-495538,EBI-1051034 MINT-7137103 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA17557115
    GO:0006351transcription, DNA-templated IEA--
    GO:0006915apoptotic process TAS--
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process TAS--
    GO:0006925inflammatory cell apoptotic process IEA--

    FASLG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FASLG (TNFL6)

    Selected Novoseek inferred chemical compound relationships for FASLG gene (see all 146)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    concanamycin a 61 2 19307993 (1), 10975816 (1)
    dutp 60.1 6 12393527 (1), 12957613 (1), 17536279 (1), 14746617 (1) (see all 6)
    ionomycin 50 35 9823934 (4), 10754388 (3), 10570264 (2), 8566027 (2) (see all 18)
    sp 600125 46.1 6 19927172 (1), 17459422 (1), 18941206 (1), 17397922 (1)
    cycloheximide 43.9 15 9574534 (1), 10440872 (1), 10540161 (1), 10066786 (1) (see all 9)
    antalarmin 41.8 2 14644813 (1), 15032629 (1)
    c-d4t 39.6 3 17180098 (1), 16212887 (1)
    adpribose 38.9 3 11205313 (1), 17962376 (1), 19282377 (1)
    oleandrin 37.1 2 17173971 (1), 17203245 (1)
    ceramide 37.1 17 9321399 (4), 10745271 (3), 18613813 (2), 16927017 (1) (see all 9)



    FASLG for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FASLG gene: 
    NM_000639.1  

    Unigene Cluster for FASLG:

    Fas ligand (TNF superfamily, member 6)
    Hs.2007  [show with all ESTs]
    Unigene Representative Sequence: NM_000639
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367721(uc001gis.3) ENST00000340030(uc001git.3)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FASLG (see all 14):
    hsa-miR-98 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-3653 hsa-let-7i hsa-miR-21 hsa-let-7e
    SwitchGear 3'UTR luciferase reporter plasmidFASLG 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FASLG
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FASLG (NM_000639)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FASLG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FASLG
    Primer
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    OriGene qPCR primer pairs and template standards for FASLG
    OriGene qSTAR qPCR primer pairs in human, mouse for FASLG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FASLG
      QuantiTect SYBR Green Assays in human, mouse, rat FASLG
      QuantiFast Probe-based Assays in human, mouse, rat FASLG

    Additional mRNA sequence: 

    AF288573.1 AK314874.1 AY225406.1 AY858799.1 BC017502.1 D38122.1 U08137.1 U11821.1 
    X89102.1 

    1 DOTS entry:

    DT.309278 

    14 AceView cDNA sequences:

    X89102 BC017502 U08137 NM_000639 AY225406 BX283930 AF288573 D38122 
    BG744522 U11821 BP377614 BG745161 AA361832 BI824995 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FASLG expression in normal human tissues (normalized intensities)      FASLG embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATAAAAAG
    FASLG Expression
    About this image


    FASLG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Natural Killer Cells Peripheral Blood
             Natural killer-like cells
             nk cells   
     
     Placenta (Extraembryonic Tissues)
             Extravillous Cytotrophoblast Cells Extravillous Cytotrophoblast Layer
    FASLG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FASLG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2007
        Pathway & Disease-focused RT2 Profiler PCR Arrays including FASLG (see all 26): 
              Multiple Sclerosis in human mouse rat
              Cancer PathwayFinder in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Neurotoxicity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FASLG gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fasl1 , 5 Fas ligand (TNF superfamily, member 6)1, 5 82.8(n)1
    75.63(a)1
      1 (69.95 cM)5
    141031  NM_010177.41  NP_034307.11 
     1617806915 
    chicken
    (Gallus gallus)
    Aves FASLG1 Fas ligand (TNF superfamily, member 6) 62.02(n)
    55.38(a)
      429064  NM_001031559.1  NP_001026730.1 
    lizard
    (Anolis carolinensis)
    Reptilia FASLG6
    Fas ligand (TNF superfamily, member 6)
    50(a)
    1 ↔ 1
    GL343300.1(1381150-1388978)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia faslg1 Fas ligand (TNF superfamily, member 6) 53.87(n)
    47.2(a)
      100124789  XM_002934153.2  XP_002934199.2 
    zebrafish
    (Danio rerio)
    Actinopterygii faslg1 Fas ligand (TNF superfamily, member 6) 48.95(n)
    35.27(a)
      735295  NM_001042701.2  NP_001036166.1 


    ENSEMBL Gene Tree for FASLG (if available)
    TreeFam Gene Tree for FASLG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FASLG gene
    TNFSF152  LTA2  TNFSF142  TNF2  
    1 SIMAP similar gene for FASLG using alignment to 3 protein entries:     TNFL6_HUMAN (see all proteins):
    TNF

    FASLG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FASLG (see all 248)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs7631101,2
    C,F,A,Hpathogenic1179180467(+) CATTGT/CGAAAT 1 -- us2k121Minor allele frequency- C:0.46NS EA NA WA CSA 2336
    rs803582381,2
    Cpathogenic1179187744(+) ACTCAA/GGGTCC 2 R G mis10--------
    rs97872481,2
    C--143851277(+) ACTACA/CAAAAA 1 -- us2k11Minor allele frequency- C:0.00WA 2
    rs113243071,2
    C--143859199(+) ACGTT-/GTTGAG 1 -- int11Minor allele frequency- G:0.00CSA 2
    rs1119588721,2
    F--143859199(+) ACGTTG/TTTGAG 1 -- int12Minor allele frequency- T:0.50CSA 4
    rs106405131,2
    C--143860366(+) TAGGg-/GTgtgtg 1 -- ut310--------
    rs359355231,2
    C--143860367(+) AGGGG-/GTTGTGT 1 -- ut310--------
    rs1123750451,2
    C,F--179179155(+) GGGGGG/CCAGTA 1 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs1456932441,2
    C--179179155(+) GGGGG-/CCAGTA 1 -- us2k10--------
    rs1876356091,2
    --179179187(+) CAGGTA/CTCAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FASLG (172628154 - 172636014 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FASLG: --
    Human Gene Mutation Database (HGMD): FASLG
    Locus Specific Mutation Databases (LSDB): FASLG

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FASLG
    DNA2.0 Custom Variant and Variant Library Synthesis for FASLG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 134638   
    OMIM disorders: 601859  211980  
    UniProtKB/Swiss-Prot: TNFL6_HUMAN, P48023
  • Autoimmune lymphoproliferative syndrome 1B (ALPS1B) [MIM:601859]: A disorder of apoptosis that manifests
    in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by
    non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and
    neutropenia. Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for FASLG (see all 233):    About MalaCards
    lyell syndrome    faslg-related autoimmune lymphoproliferative syndrome    silicosis    toxic epidermal necrolysis
    autoimmune lymphoproliferative syndrome    idiopathic anterior uveitis    anterior uveitis    type ii mixed cryoglobulinemia
    autoimmune lymphoproliferative syndrome, type ib    graft versus host disease    htlv-1 associated myelopathy/tropical spastic paraparesis    vogt-koyanagi-harada disease
    nontoxic goiter    stevens-johnson syndrome    tropical spastic paraparesis    epstein-barr virus-associated gastric carcinoma
    cytomegalovirus retinitis    htlv-1 associated myelopathy    acute myocarditis    spastic paraparesis

    8 diseases from the University of Copenhagen DISEASES database for FASLG:
    Cancer     Hypersensitivity reaction type II disease     Autoimmune lymphoproliferative syndrome     Hepatitis
    Thyroiditis     Stevens-Johnson syndrome     Vascular disease     Human immunodeficiency virus infectious disease

    FASLG for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for FASLG gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune lymphoproliferative syndrome 72.6 5 10672498 (1), 19176318 (1), 8787672 (1), 17062728 (1)
    necrosis 72.1 260 8996241 (2), 11422744 (2), 18314443 (2), 11384965 (2) (see all 99)
    tumors 70.7 953 15585624 (8), 14515265 (7), 14766381 (6), 12949796 (6) (see all 99)
    tumor escape 66.9 8 15968727 (1), 10586378 (1), 10652626 (1), 11523216 (1) (see all 8)
    leukemia lymphocytic large granular 61.7 2 10652626 (1), 10492090 (1)
    toxic epidermal necrolysis 61.1 2 11799383 (1), 17977827 (1)
    hashimotos thyroiditis 55.3 27 12559631 (4), 9396343 (3), 16219172 (2), 17558708 (2) (see all 16)
    autoimmune diseases 53.2 22 7533498 (2), 10548879 (1), 14555216 (1), 18361934 (1) (see all 18)
    stevens-johnson syndrome 52.7 1 11799383 (1)
    cancer 51.4 166 12854132 (5), 11927015 (4), 14680559 (4), 10817504 (3) (see all 99)

    GeneTests: FASLG
    GeneReviews: FASLG
    Genetic Association Database (GAD): FASLG
    Human Genome Epidemiology (HuGE) Navigator: FASLG (99 documents)

    Export disorders for FASLG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FASLG gene, integrated from 10 sources (see all 1932):
    (articles sorted by number of sources associating them with FASLG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease. (PubMed id 8787672)1, 2, 4, 9 Wu J.... Mountz J.D. (J. Clin. Invest. 1996)
    2. Human Fas ligand: gene structure, chromosomal location and species specificity. (PubMed id 7826947)1, 2, 3, 9 Takahashi T.... Nagata S. (Int. Immunol. 1994)
    3. Study of Fas (CD95) and FasL (CD178) polymorphisms in liver transplant recipients. (PubMed id 16441482)1, 4, 9 MarA-n L.A....Alvarez-LA^pez M.R. (Tissue Antigens 2006)
    4. The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells. (PubMed id 17557115)1, 2, 9 Kirkin V....Zornig M. (Cell Death Differ. 2007)
    5. Genetic polymorphisms of Fas (CD95) and Fas ligand (CD178) influence the rise in CD4+ T cell count after antiretroviral therapy in drug-naA^ve HIV-positive patients. (PubMed id 16158329)1, 4, 9 Nasi M....Cossarizza A. (Immunogenetics 2005)
    6. Prognostic significance of the Fas-receptor/Fas-ligand system in cervical squamous cell carcinoma. (PubMed id 18000680)1, 4, 9 Lerma E....Prat J. (Virchows Arch. 2008)
    7. Functional variants in cell death pathway genes and risk of pancreatic cancer. (PubMed id 18483392)1, 4, 9 Yang M....Lin D. (Clin. Cancer Res. 2008)
    8. FAS and FAS ligand polymorphisms in the promoter regions and risk of gastric cancer in Southern China. (PubMed id 19565204)1, 4, 9 Wang M....Zhang Z. (Biochem. Genet. 2009)
    9. The -509C/T polymorphism of transforming growth factor-beta1 is associated with increased risk for development of chronic idiopathic neutropenia. (PubMed id 19614955)1, 4, 9 Eliopoulos D.G....Papadaki H.A. (Eur. J. Haematol. 2009)
    10. Genetic polymorphisms of IL-1A, IL-1B, IL-1RN, NFKB1, FAS, and FASL, and risk of silicosis in a Chinese occupational population. (PubMed id 18666137)1, 4, 9 Wu F....Christiani D.C. (Am. J. Ind. Med. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 356 HGNC: 11936 AceView: TNFSF6 Ensembl:ENSG00000117560 euGenes: HUgn356
    ECgene: FASLG Kegg: 356 H-InvDB: FASLG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FASLG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FASLG Genetics and Cytogenetics in Oncology and Haematology
    FASLGbasehttp://bioinf.uta.fi/FASLGbase/
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=FASLG[genesymbol]
    Wikipedia http://en.wikipedia.org/wiki/FAS_ligand

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FASLG gene:
    Search GeneIP for patents involving FASLG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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