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FASLG Gene

protein-coding GIFtS: 65

GC01P170894

Fas ligand (TNF superfamily, member 6)
(Previous names: tumor necrosis factor (ligand) superfamily, member 6 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: APT1LG1, TNFSF6)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
APT1LG1 ^², ³
APTL ^³
CD178 ^¹, ²
CD95L ^²
FASL ^², ³
FasL ^¹
OTTHUMP00000032708 ^²
TNFSF6 ^², ³

Descriptions
Apoptosis antigen ligand ^³
CD178 antigen ^³
CD95 ligand ^²
CD95L protein ^³
Fas antigen ligand ^³
Fas ligand ^², ³
Fas ligand (TNF superfamily, member 6) ^²
apoptosis (APO-1) antigen ligand 1 ^²
tumor necrosis factor (ligand) superfamily, member 6 ^¹, ²

External Ids
HGNC: 11936¹
Entrez Gene: 356²
UniProtKB: P48023³
Ensembl: ENSG00000117560⁷

Search outside databases for aliases for FASLG gene

Previous GC identifer: GC01P169360

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FASLG:

The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins.

Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells

such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus

erythematosus (SLE). [provided by RefSeq]

UniProtKB/Swiss-Prot: TNFL6_HUMAN, P48023

Function: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into

cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development.

TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the

antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3

modulates its effects

Gene Wiki entry for FASLG (Fas_ligand)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FASLG gene

Entrez Gene cytogenetic band: 1q23 Ensembl cytogenetic band: 1q24.3 HGNC cytogenetic band: 1q23

FASLG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P170894: (about GC identifiers)

Start:	170,894,777 bp from pter
End:	170,902,637 bp from pter
Size:	7,861 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TNFL6_HUMAN, P48023 (See protein sequence)

Recommended Name: Tumor necrosis factor ligand superfamily member 6

Size: 281 amino acids; 31485 Da

Subunit: Homotrimer (Probable)

Subcellular location: Cell membrane; Single-pass type II membrane protein. Secreted. Note=May be

released into the extracellular fluid, probably by cleavage form the cell surface

PDB structures from and Proteopedia :

1BZI (3D)

Secondary accessions: Q9BZP9

Alternative splicing: 2 isoforms: P48023-1 P48023-2

Post-translational modifications:

N-glycosylated¹

The soluble form derives from the membrane form by proteolytic processing¹

REFSEQ proteins: NP_000630.1

ENSEMBL proteins:

ENSP00000356694 ENSP00000344739

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for FASLG
	R&D Systems Recombinant & Natural Proteins for FASLG (Fas Ligand/TNFSF6)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Fas Ligand)
	Human Recombinant Proteins from Abnova (FASLG)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	7826947

About this table

Antibodies for FASLG:

	Invitrogen Antibodies for FASLG
	Millipore Mono- and Polyclonal Antibodies for the study of FASLG
	Sigma-Aldrich Antibody Arrays and Antibodies for FASLG
	R&D Systems Antibodies for FASLG (Fas Ligand/TNFSF6)
	Cell Signaling Technology (CST) Antibodies for FASLG (FasL)
	Antibodies from Abcam (Fas Ligand), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for FASLG

Assays for FASLG:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for FASLG (Fas Ligand/TNFSF6) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P48023

ProtoNet protein and cluster: P48023

3 Blocks protein families:

IPB006052 Tumor Necrosis Factor

IPB006053 Tumour necrosis factor family signature

IPB008064 Fas antigen ligand signature

UniProtKB/Swiss-Prot: TNFL6_HUMAN, P48023

Similarity: Belongs to the tumor necrosis factor family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FASLG)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FASLG)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000639

Applied Biosystems Silencer® siRNAs for FASLG

Sigma-Aldrich siRNA and siRNA Panels for FASLG

Sigma-Aldrich shRNA Panels and shRNA for FASLG

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FASLG
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000639
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000639
untagged cDNA clones in CMV expression vector (see all 2): NM_000639

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000639

UniProtKB/Swiss-Prot: TNFL6_HUMAN, P48023

Function: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into

cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development.

TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the

antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3

modulates its effects

15/17 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Fasl) (see all 17 ):

	digestive/alimentary	endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism
immune system	life span-post-weaning/aging	liver/biliary system	nervous system	normal
renal/urinary system	reproductive system	respiratory system	skeleton	skin/coat/nails

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--
GO:0005164	tumor necrosis factor receptor binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/15 Sigma-Aldrich "Your Favorite Gene" Pathways for FASLG (Your Favorite Gene powered by Ingenuity) (see all 15 )

Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells
Graft-versus-Host Disease Signaling
Apoptosis Signaling
Molecular Mechanisms of Cancer
Corticotropin Releasing Hormone Signaling

GeneDecks FASLG for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for FASLG

5/174 Interacting proteins for FASLG (P48023² ENSP00000356694³) via UniProtKB, MINT, and/or STRING (see all 174 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CASP8	Q14790², ENSP00000351273³	MINT-1956272 STRING (score=.999)
FADD	Q13158², ENSP00000301838³	MINT-1956230 STRING (score=.999)
CASP10	ENSP00000286186³	STRING (score=.999)
FAS	ENSP00000360942³	STRING (score=.999)
RTEL1	ENSP00000349265³	STRING (score=.999)

About this table

5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006955	immune response	IEA	--
GO:0007165	signal transduction	TAS	7826947
GO:0007267	cell-cell signaling	TAS	7826947
GO:0008624	induction of apoptosis by extracellular signals	EXP	11048727
GO:0008633	activation of pro-apoptotic gene products	EXP	14644197

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FASLG
10/51 Novoseek chemical compound relationships for FASLG gene (see all 51 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dutp	59.55	5	12393527 (1), 12957613 (1), 17536279 (1), 14746617 (1) (see all 5)
ionomycin	50.85	35	9823934 (4), 10754388 (3), 10570264 (2), 8566027 (2) (see all 18)
antalarmin	43.45	2	14644813 (1), 15032629 (1)
sp 600125	40.25	3	17459422 (1), 18941206 (1), 17397922 (1)
oleandrin	38.33	2	17173971 (1), 17203245 (1)
ceramide	37.23	16	9321399 (4), 10745271 (3), 18613813 (2), 16927017 (1) (see all 8)
c-d4t	35.23	3	17180098 (1), 16212887 (1)
atpo	33.22	5	17558708 (3), 17357290 (2)
(glc)4	28.68	2	10656451 (1)
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide	25.04	2	18471799 (1), 19305072 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FASLG)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FASLG)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000639

Sigma-Aldrich siRNA and siRNA Panels for FASLG

Sigma-Aldrich shRNA Panels and shRNA for FASLG

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000639

REFSEQ mRNAs for FASLG gene:

NM_000639.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000639

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000639
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000639
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000639

Additional cDNA sequence:

AF288573.1 AK314874.1 AY225406.1 AY858799.1 BC017502.1 D38122.1 U08137.1 U11821.1

X89102.1

1 DOTS entry:

DT.309278

14 AceView cDNA sequences:

X89102 U08137 BC017502 NM_000639 AY225406 D38122 U11821 BG744522

AF288573 BX283930 BP377614 BG745161 AA361832 BI824995

highest scoring ESTs for FASLG:

D38122 U11821 AA361832 AF288573 AY225406 BC017502 BG744522 BG745161 U08137 X89102

Unigene Cluster for FASLG:

Fas ligand (TNF superfamily, member 6)

Hs.2007 [show with all ESTs]

Unigene Representative Sequence: NM_000639

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000367721 ENST00000340030

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FASLG expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FASLG

¹ / ² / ³

6 probe-sets matching FASLG gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1851_s_at²^{, 3}	U95-A	1	1.00	1.00	0.97	0.66	U11821	1.00	1.00	1.00	1
1858_at²^{, 3}	U95-A	1	1.00	1.00	0.98	1.36	D38122	1.00	1.00	1.00	1
211333_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF288573	0.80	1.00	0.91	1
210865_at²^{, 3}	U133-A	1	1.00	1.00	--	--	D38122	1.00	1.00	1.00	1
211333_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210865_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks FASLG for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAATAAAAAG

SOURCE GeneReport for Unigene cluster: Hs.2007

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FASLG gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FASLG¹	--	Fas ligand (TNF superfamily, member 6)	88.14(n) 88.26(a)	442968 XM_848916.1 XP_854009.1
chimpanzee (Pan troglodytes)	FASLG¹	--	Fas ligand (TNF superfamily, member 6)	99.64(n) 99.64(a)	469584 XM_524967.2 XP_524967.2
cow (Bos taurus)	LOC784352¹	--	similar to LOC407111 protein	88.21(n) 87.36(a)	784352 XM_001252797.1 XP_001252798.1
rat (Rattus norvegicus)	Faslg¹	--	Fas ligand (TNF superfamily, member 6)	82.31(n) 77.98(a)	25385 NM_012908.1 NP_037040.1
mouse (Mus musculus)	Fasl^{1, 5}	1 (85.00 cM)⁵	Fas ligand (TNF superfamily, member 6)^{1, 5}	84.05(n)¹ 78.42(a)¹	14103¹ NM_010177.3¹ NP_034307.1¹ AF045739⁵ AF119335⁵ (see all 14)

About this table Species with no ortholog for FASLG

ENSEMBL Gene Tree for FASLG

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FASLG gene

TNFSF15² ENSG00000204496² TNF² TNFSF14²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/73 NCBI SNPs in FASLG are shown (see all 73 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 50)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs6690331^1,2	A,C,F,H	170903090(+)	`CACTAC/TTAAGC`	1	--	ng3¹		11		EU EA WA NA	970
--	rs763110^1,2	A,C,F,H	170894121(+)	`CATTGC/TGAAAT`	1	--	ng5¹		4		EU EA WA	410
	rs2021837^1,2	A,C,H	170894209(-)	`CATAAT/CTTACA`	1	--	ng5¹		3		EU EA	284
--	rs16844867^1,2	F	170893088(+)	`AAAACT/CAACGA`	1	--	ng5¹ tfbs³		3		NA	142
--	rs12079514^1,2	H	170901499(+)	`GCTGTA/CCTTTG`	1	Y/S	mis¹		4		EU EA WA	406
	rs2859248^1,2	C	170893003(+)	`ATCAGA/GGAAAT`	1	--	ng5¹		0	--	--	--	--
	rs17475^1,2	H	170902012(+)	`CCATGT/AGAAGA`	1	--	ut3¹		4		EU EA WA	418
	rs929087^1,2	A,C,F,H,O	170898680(+)	`TGCAGG/AGGAGA`	1	--	int¹		14		EA NA EU WA	1230
	rs6700734^1,2	A,C,F,H	170897434(+)	`GGTAAA/GTCATC`	1	--	int¹		17		EU EA WA NS NA	1160
	rs10458360^1,2	A,C,F,H	170900598(+)	`GTAGAC/GTTTCA`	1	--	int¹		21		EA NA EU WA	1901

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HapMap Linkage Disequilibrium images for FASLG (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 134638

UniProtKB/Swiss-Prot: TNFL6_HUMAN, P48023

Defects in FASLG are the cause of autoimmune lymphoproliferative syndrome type 1B (ALPS1B)

[MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving

hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly

10/94 Novoseek disease relationships for FASLG gene (see all 94 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
autoimmune lymphoproliferative syndrome	72.72	5	10672498 (1), 19176318 (1), 8787672 (1), 17062728 (1)
necrosis	71.49	242	8996241 (2), 11422744 (2), 18314443 (2), 11384965 (2) (see all 99)
tumors	70.43	911	15585624 (8), 14515265 (7), 14766381 (6), 12949796 (6) (see all 99)
tumor escape	68.04	8	15968727 (1), 10586378 (1), 10652626 (1), 11523216 (1) (see all 8)
leukemia lymphocytic large granular	62.66	2	10652626 (1), 10492090 (1)
toxic epidermal necrolysis	60.73	2	11799383 (1), 17977827 (1)
hashimotos thyroiditis	56.52	27	12559631 (4), 9396343 (3), 16219172 (2), 17558708 (2) (see all 16)
autoimmune diseases	53.79	22	7533498 (2), 10548879 (1), 14555216 (1), 18361934 (1) (see all 18)
cancer	49.60	153	12854132 (5), 11927015 (4), 14680559 (4), 10817504 (3) (see all 93)
stevens-johnson syndrome	49.51	1	11799383 (1)

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GeneTests: FASLG

Autoimmune Lymphoproliferative Syndrome

Human Gene Mutation Database: FASLG
Genetic Association Database: FASLG
Human Genome Epidemiology Navigator: FASLG (62 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1605 PubMed articles for FASLG gene (see all 1605 ):

Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease. (PubMed id 8787672)^{1, 3, 4, 6} Wu J.... Mountz J.D. (1996)
Human Fas ligand: gene structure, chromosomal location and species specificity. (PubMed id 7826947)^{1, 2, 3, 4} Takahashi T.... Nagata S. (1994)
Genetic polymorphisms of Fas (CD95) and Fas ligand (CD178) influence the rise in CD4+ T cell count after antiretroviral therapy in drug-naive HIV-positive patients. (PubMed id 16158329)^{1, 3, 6} Nasi M....Cossarizza A. (2005)
Fas ligand gene polymorphisms are not associated with Hashimoto's thyroiditis and Graves' disease. (PubMed id 12559631)^{1, 3, 6} Stuck B.J....Badenhoop K. (2003)
The -844C/T polymorphism in the Fas ligand promoter associates with Taiwanese SLE. (PubMed id 15674374)^{1, 3, 6} Chen J.Y....Luo S.F. (2005)
Fas and Fas ligand gene polymorphisms in primary Sjogren's syndrome. (PubMed id 11036836)^{1, 3, 6} Bolstad A.I....Jonsson R. (2000)
Characterization of Fas (Apo-1, CD95)-Fas ligand interaction. (PubMed id 9228058)^{1, 3, 4} Schneider P.... Tschopp J. (1997)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
Functional polymorphisms in cell death pathway genes FAS and FASL contribute to risk of lung cancer. (PubMed id 15937082)^{3, 6} Zhang X....Lin D. (2005)
Polymorphisms in the promoter regions of FAS and FASL genes as candidate genetic factors conferring susceptibility to endometriosis. (PubMed id 15806311)^{3, 6} Fernandez R.M....Antinolo G. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 356	HGNC: 11936	AceView: TNFSF6	Ensembl:ENSG00000117560	euGenes: HUgn356
ECgene: FASLG	H-InvDB: FASLG

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for FASLG	Genetics and Cytogenetics in Oncology and Haematology
FASLGbase	http://bioinf.uta.fi/FASLGbase/
GeneReviews	http://www.genetests.org/query?gene=FASLG
Wikipedia	http://en.wikipedia.org/wiki/FAS_ligand

Licensable Technologies for FASLG
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FASLG:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FASLG-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FASLG		Antibodies for FASLG
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Antibodies & Assays for FASLG (FasL)

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	Antibodies (Fas Ligand)

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Antibodies for FASLG

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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FASLG Gene at Home site.
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FASLG Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for FASLG

Summaries
for FASLG

Genomic Location
for FASLG

Proteins
for FASLG

Protein Domains/
Families
for FASLG

Gene Function
for FASLG

Pathways & Interactions
for FASLG

Drugs & Compounds
for FASLG

Transcripts
for FASLG

Expression
for FASLG

Orthologs
for FASLG

Paralogs
for FASLG

SNPs/Variants
for FASLG

Disorders & Mutations
for FASLG

Medical News
for FASLG

Publications
for FASLG

Search for FASLG

Genome Databases showing FASLG

Other Databases showing FASLG

Specialized Databases showing FASLG

Licensable Technologies
for FASLG

Services
for FASLG

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FASLG Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor FASLG

Summariesfor FASLG

Genomic Locationfor FASLG

Proteinsfor FASLG

Protein Domains/Familiesfor FASLG

Gene Functionfor FASLG

Pathways & Interactionsfor FASLG

Drugs & Compoundsfor FASLG

Transcriptsfor FASLG

Expression for FASLG

Orthologsfor FASLG

Paralogsfor FASLG

SNPs/Variantsfor FASLG

Disorders & Mutationsfor FASLG

Medical Newsfor FASLG

Publicationsfor FASLG

Search for FASLG

Genome Databases showing FASLG

Other Databases showing FASLG

Specialized Databases showing FASLG

Licensable Technologiesfor FASLG

Servicesfor FASLG

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FASLG

Summaries
for FASLG

Genomic Location
for FASLG

Proteins
for FASLG

Protein Domains/
Families
for FASLG

Gene Function
for FASLG

Pathways & Interactions
for FASLG

Drugs & Compounds
for FASLG

Transcripts
for FASLG

Expression
for FASLG

Orthologs
for FASLG

Paralogs
for FASLG

SNPs/Variants
for FASLG

Disorders & Mutations
for FASLG

Medical News
for FASLG

Publications
for FASLG

Licensable Technologies
for FASLG

Services
for FASLG