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Aliases for FASLG Gene

Aliases for FASLG Gene

  • Fas Ligand 2 3 4 5
  • Fas Ligand (TNF Superfamily, Member 6) 2 3
  • Apoptosis Antigen Ligand 3 4
  • Fas Antigen Ligand 3 4
  • CD95 Ligand 3 4
  • APT1LG1 3 4
  • TNFSF6 3 4
  • CD95-L 3 4
  • CD95L 3 4
  • APTL 3 4
  • FASL 3 4
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 6 2
  • Mutant Tumor Necrosis Factor Family Member 6 3
  • Apoptosis (APO-1) Antigen Ligand 1 3
  • Tumor Necrosis Factor Ligand 1A 3
  • CD178 Antigen 4
  • ALPS1B 3
  • TNLG1A 3
  • CD178 3

External Ids for FASLG Gene

Previous HGNC Symbols for FASLG Gene

  • APT1LG1
  • TNFSF6

Previous GeneCards Identifiers for FASLG Gene

  • GC01P169360
  • GC01P170894
  • GC01P143852

Summaries for FASLG Gene

Entrez Gene Summary for FASLG Gene

  • This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]

GeneCards Summary for FASLG Gene

FASLG (Fas Ligand) is a Protein Coding gene. Diseases associated with FASLG include Autoimmune Lymphoproliferative Syndrome and Lung Cancer. Among its related pathways are TNF Signaling (sino) and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. GO annotations related to this gene include receptor binding and tumor necrosis factor receptor binding. An important paralog of this gene is TNF.

UniProtKB/Swiss-Prot for FASLG Gene

  • Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.

  • The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition.

Gene Wiki entry for FASLG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FASLG Gene

Genomics for FASLG Gene

Regulatory Elements for FASLG Gene

Enhancers for FASLG Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FASLG on UCSC Golden Path with GeneCards custom track

Genomic Location for FASLG Gene

Chromosome:
1
Start:
172,659,008 bp from pter
End:
172,666,874 bp from pter
Size:
7,867 bases
Orientation:
Plus strand

Genomic View for FASLG Gene

Genes around FASLG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FASLG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FASLG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FASLG Gene

Proteins for FASLG Gene

  • Protein details for FASLG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48023-TNFL6_HUMAN
    Recommended name:
    Tumor necrosis factor ligand superfamily member 6
    Protein Accession:
    P48023
    Secondary Accessions:
    • Q9BZP9

    Protein attributes for FASLG Gene

    Size:
    281 amino acids
    Molecular mass:
    31485 Da
    Quaternary structure:
    • Homotrimer (Probable). Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1.

    Three dimensional structures from OCA and Proteopedia for FASLG Gene

    Alternative splice isoforms for FASLG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FASLG Gene

Proteomics data for FASLG Gene at MOPED

Post-translational modifications for FASLG Gene

  • Monoubiquitinated.
  • N-glycosylated.
  • Phosphorylated by FGR on tyrosine residues; this is required for ubiquitination and subsequent internalization.
  • The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form undergoes two successive intramembrane proteolytic cleavages. The first one is processed by ADAM10 producing an N-terminal fragment, which lacks the receptor-binding extracellular domain. This ADAM10-processed FasL (FasL APL) remnant form is still membrane anchored and further processed by SPPL2A that liberates the FasL intracellular domain (FasL ICD). FasL shedding by ADAM10 is a prerequisite for subsequent intramembrane cleavage by SPPL2A in T-cells.
  • Glycosylation at Asn 184, Asn 250, and Asn 260
  • Modification sites at PhosphoSitePlus

Other Protein References for FASLG Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for FASLG (Fas Ligand/TNFSF6)
  • Cell Signaling Technology (CST) Antibodies for FASLG (FasL)

Assay Products

  • Enzo Life Sciences assays for FASLG
  • Cloud-Clone Corp Assay Kits for FASLG

No data available for DME Specific Peptides for FASLG Gene

Domains & Families for FASLG Gene

Graphical View of Domain Structure for InterPro Entry

P48023

UniProtKB/Swiss-Prot:

TNFL6_HUMAN :
  • Belongs to the tumor necrosis factor family.
Family:
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with FASLG: view

Function for FASLG Gene

Molecular function for FASLG Gene

UniProtKB/Swiss-Prot Function:
Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.
UniProtKB/Swiss-Prot Function:
The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition.
genes like me logo Genes that share phenotypes with FASLG: view

Human Phenotype Ontology for FASLG Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FASLG Gene

MGI Knock Outs for FASLG:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for FASLG Gene

Localization for FASLG Gene

Subcellular locations from UniProtKB/Swiss-Prot for FASLG Gene

Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle lumen. Lysosome lumen. Note=Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination. Colocalizes with the SPPL2A protease at the cell membrane.
Tumor necrosis factor ligand superfamily member 6, soluble form: Secreted. Note=May be released into the extracellular fluid, probably by cleavage form the cell surface. {ECO:0000250}.
FasL intracellular domain: Nucleus. Note=The FasL ICD cytoplasmic form is translocated into the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FASLG Gene COMPARTMENTS Subcellular localization image for FASLG gene
Compartment Confidence
extracellular 5
lysosome 5
nucleus 5
plasma membrane 5
vacuole 5
cytosol 4
mitochondrion 3
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FASLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17557115
GO:0005901 caveola IEA --
GO:0043202 lysosomal lumen IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with FASLG: view

Pathways & Interactions for FASLG Gene

genes like me logo Genes that share pathways with FASLG: view

Pathways by source for FASLG Gene

SIGNOR curated interactions for FASLG Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for FASLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 17557115
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS --
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 7826947
GO:0007166 cell surface receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with FASLG: view

Drugs & Compounds for FASLG Gene

(82) Drugs for FASLG Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
APG101 Pharma 0

(65) Additional Compounds for FASLG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FASLG: view

Transcripts for FASLG Gene

mRNA/cDNA for FASLG Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FASLG Gene

Fas ligand (TNF superfamily, member 6):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FASLG Gene

No ASD Table

Relevant External Links for FASLG Gene

GeneLoc Exon Structure for
FASLG
ECgene alternative splicing isoforms for
FASLG

Expression for FASLG Gene

mRNA expression in normal human tissues for FASLG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FASLG Gene

This gene is overexpressed in Whole Blood (x17.4) and Spleen (x11.4).

Protein differential expression in normal tissues from HIPED for FASLG Gene

This gene is overexpressed in Monocytes (45.4) and Neutrophil (23.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FASLG Gene



SOURCE GeneReport for Unigene cluster for FASLG Gene Hs.2007

genes like me logo Genes that share expression patterns with FASLG: view

Protein tissue co-expression partners for FASLG Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for FASLG Gene

Orthologs for FASLG Gene

This gene was present in the common ancestor of chordates.

Orthologs for FASLG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FASLG 35
  • 87.24 (n)
  • 85.56 (a)
FASLG 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FASLG 35
  • 87.9 (n)
  • 87.54 (a)
FASLG 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fasl 35
  • 82.8 (n)
  • 75.63 (a)
Fasl 16
Fasl 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FASLG 35
  • 99.64 (n)
  • 99.64 (a)
FASLG 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Faslg 35
  • 81.65 (n)
  • 74.82 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia FASLG 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves FASLG 35
  • 62.02 (n)
  • 55.38 (a)
FASLG 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FASLG 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia faslg 35
  • 53.87 (n)
  • 47.2 (a)
zebrafish
(Danio rerio)
Actinopterygii faslg 35
  • 48.95 (n)
  • 35.27 (a)
faslg 36
  • 29 (a)
OneToOne
Species with no ortholog for FASLG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FASLG Gene

ENSEMBL:
Gene Tree for FASLG (if available)
TreeFam:
Gene Tree for FASLG (if available)

Paralogs for FASLG Gene

Paralogs for FASLG Gene

(1) SIMAP similar genes for FASLG Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FASLG: view

Variants for FASLG Gene

Sequence variations from dbSNP and Humsavar for FASLG Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs12079514 - 172,665,736(+) GCTGT(A/C)CTTTG reference, missense, utr-variant-3-prime
VAR_075568 Autoimmune lymphoproliferative syndrome 1B (ALPS1B)
rs17475 -- 172,666,249(+) CCATG(A/T)GAAGA utr-variant-3-prime
rs17476 -- 172,666,266(+) AGCAT(C/G)AAAAA utr-variant-3-prime
rs749154 -- 172,658,079(+) TGTCT(C/T)GAAGC upstream-variant-2KB

Variation tolerance for FASLG Gene

Residual Variation Intolerance Score: 53.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FASLG Gene

Human Gene Mutation Database (HGMD)
FASLG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FASLG Gene

Disorders for FASLG Gene

MalaCards: The human disease database

(48) MalaCards diseases for FASLG Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
autoimmune lymphoproliferative syndrome
  • coffin-siris syndrome
lung cancer
  • lung cancer, protection against
faslg-related autoimmune lymphoproliferative syndrome
silicosis
  • pneumoconiosis due to silicates
acute t cell leukemia
  • precursor t lymphoblastic leukemia
- elite association - COSMIC cancer census association via MalaCards
Search FASLG in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TNFL6_HUMAN
  • Autoimmune lymphoproliferative syndrome 1B (ALPS1B) [MIM:601859]: A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia. {ECO:0000269 PubMed:26334989, ECO:0000269 PubMed:8787672}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for FASLG

Genetic Association Database (GAD)
FASLG
Human Genome Epidemiology (HuGE) Navigator
FASLG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FASLG
genes like me logo Genes that share disorders with FASLG: view

No data available for Genatlas for FASLG Gene

Publications for FASLG Gene

  1. Human Fas ligand: gene structure, chromosomal location and species specificity. (PMID: 7826947) Takahashi T. … Nagata S. (Int. Immunol. 1994) 2 3 4 67
  2. Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death. (PMID: 19779494) Lafont E. … SAcgui B. (Cell Death Differ. 2010) 3 23
  3. Acrolein induces apoptosis through the death receptor pathway in A549 lung cells: role of p53. (PMID: 20393600) Roy J. … Averill-Bates D.A. (Can. J. Physiol. Pharmacol. 2010) 3 23
  4. FasL gene knock-down therapy enhances the antiglioma immune response. (PMID: 20406899) Jansen T. … Olivi A. (Neuro-oncology 2010) 3 23
  5. Expressions of Fas/DcR3 and RGD-FasL mediated apoptosis in pituitary adenomas. (PMID: 19305072) Chen L. … Zhuang G. (Neurol India 2009) 3 23

Products for FASLG Gene

Sources for FASLG Gene

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