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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FASLG Gene

protein-coding GIFtS: 68
GCID: GC01P172628

Fas ligand (TNF superfamily, member 6)

(Previous names: tumor necrosis factor (ligand) superfamily, member 6 )
(Previous symbols: APT1LG1, TNFSF6)

Explore 243 diseases affiliated with
FASLG via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Fas Ligand (TNF Superfamily, Member 6)¹ ²		APTL² ³
APT1LG1¹ ² ³ ⁵		CD95-L² ³
TNFSF6¹ ² ³ ⁵		CD95L² ³
FASL² ³ ⁵		CD95 Ligand² ³
CD178¹ ²		ALPS1B²
Tumor Necrosis Factor (Ligand) Superfamily, Member 6¹ ²		Apoptosis (APO-1) Antigen Ligand 1²
FasL¹ ³		Tumor Necrosis Factor Ligand Superfamily Member 6²
Apoptosis Antigen Ligand² ³		CD178 Antigen³
Fas Antigen Ligand² ³		Fas Ligand³

External Ids:	HGNC: 11936¹	Entrez Gene: 356²	Ensembl: ENSG00000117560⁷	OMIM: 134638⁵	UniProtKB: P48023³

Export aliases for FASLG gene to outside databases

Previous GC identifers: GC01P169360 GC01P170894 GC01P143852

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FASLG:

The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this

ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be

related to some cases of systemic lupus erythematosus (SLE). (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TNFL6_HUMAN, P48023

Function: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be

involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a

role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding

to the decoy receptor TNFRSF6B/DcR3 modulates its effects

Function: The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition

Gene Wiki entry for FASLG (Fas ligand)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FASLG gene promoter:
GR Sp1 Meis-1b FOXO1a GR-alpha Meis-1a FOXO1 Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FASLG promoter sequence

Search SABiosciences Chromatin IP Primers for FASLG

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FASLG

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23 Ensembl cytogenetic band: 1q24.3 HGNC cytogenetic band: 1q23

FASLG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FASLG gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P172628: view genomic region (about GC identifiers)

Start:	172,628,154 bp from pter	End:	172,636,014 bp from pter
Size:	7,861 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TNFL6_HUMAN, P48023 (See protein sequence)

Recommended Name: Tumor necrosis factor ligand superfamily member 6

Size: 281 amino acids; 31485 Da

Subunit: Homotrimer (Probable). Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3,

FGR, FYB, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1,

PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2,

SRGAP3, TEC, TJP3 and YES1

Subcellular location: Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle lumen. Lysosome lumen.

Note=Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and

monoubiquitination. Colocalizes with the SPPL2A protease at the cell membrane

Subcellular location: Tumor necrosis factor ligand superfamily member 6, soluble form: Secreted (By similarity).

Note=May be released into the extracellular fluid, probably by cleavage form the cell surface (By similarity)

Subcellular location: FasL intracellular domain: Nucleus. Note=The FasL ICD cytoplasmic form is translocated into the

nucleus

1 PDB 3D structure from and Proteopedia for FASLG:

1BZI (3D)

Secondary accessions: Q9BZP9

Alternative splicing: 2 isoforms: P48023-1 P48023-2

Explore the universe of human proteins at neXtProt for FASLG: NX_P48023

Post-translational modifications:

The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form undergoes two

successive intramembrane proteolytic cleavages. The first one is processed by ADAM10 producing an N-terminal fragment,

which lacks the receptor-binding extracellular domain. This ADAM10-processed FasL (FasL APL) remnant form is still

membrane anchored and further processed by SPPL2A that liberates the FasL intracellular domain (FasL ICD). FasL

shedding by ADAM10 is a prerequisite for subsequent intramembrane cleavage by SPPL2A in T-cells¹

N-glycosylated¹

Phosphorylated by FGR on tyrosine residues; this is required for ubiquitination and subsequent internalization¹

Monoubiquitinated¹

View neXtProt modification sites for NX_P48023

FASLG Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000630.1

ENSEMBL proteins:

ENSP00000356694 ENSP00000344739

Reactome Protein details: P48023
Human Recombinant Protein Products:

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	Novus Biologicals FASLG Proteins Novus Biologicals FASLG Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for FASLG
	Uscn Proteins for FASLG

Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IDA	18835034
GO:0005634	nucleus	IDA	17557115
GO:0005887	integral to plasma membrane	TAS	7826947
GO:0005901	caveola	IEA	--

FASLG for ontologies About GeneDecksing

FASLG Antibody Products:

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	Novus Biologicals FASLG Antibodies
	Abcam antibodies for FASLG
	Uscn Antibodies for FASLG
	ThermoFisher Antibodies for FASLG

Assay Products for FASLG:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for FASLG (Fas Ligand/TNFSF6) (see all)
	GenScript Custom Assay Services for FASLG
	Enzo Life Sciences assays for FASLG
	Uscn ELISAs and CLIAs for FASLG

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FASLG for domains About GeneDecksing

5 InterPro domains/families:

IPR021184 TNF_CS

IPR008064 Fas_ligand

IPR006052 TNF

IPR006053 TNF_a/b/c

IPR008983 Tumour_necrosis_fac-like_dom

Graphical View of Domain Structure for InterPro Entry P48023

ProtoNet protein and cluster: P48023

3 Blocks protein families:

IPB006052 Tumor Necrosis Factor

IPB006053 Tumour necrosis factor family signature

IPB008064 Fas antigen ligand signature

UniProtKB/Swiss-Prot: TNFL6_HUMAN, P48023

Similarity: Belongs to the tumor necrosis factor family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TNFL6_HUMAN, P48023

Function: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be

involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a

role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding

to the decoy receptor TNFRSF6B/DcR3 modulates its effects

Function: The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition

miRNA Products:		OriGene 3'-UTR Clone: FASLG Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FASLG
		8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate FASLG (see all 14):
		hsa-miR-98 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-3653 hsa-let-7i hsa-miR-21 hsa-let-7e

		SwitchGear 3'UTR luciferase reporter plasmid: FASLG 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
Products:

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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FASLG
		Search LifeMap BioReagents cell lines for FASLG

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FASLG

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	TAS	7826947
GO:0005125	cytokine activity	IEA	--
GO:0005164	tumor necrosis factor receptor binding	IEA	--
GO:0005515	protein binding	IPI	--

FASLG for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for FASLG: Fasl^tm1.1Bksa Fasl^tm1.1Lest
     15/18 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Fasl) (see all 18):

cardiovascular system	cellular	digestive/alimentary	endocrine/exocrine gland	hematopoietic system
homeostasis/metabolism	immune system	integument	liver/biliary system	mortality/aging
nervous system	normal	renal/urinary system	reproductive system	respiratory system

FASLG for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/36 super-pathways (see all 36) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptosis and survival_Caspase cascade

Apoptosis and survival_Caspase cascade	1.00	Apoptosis and survival FAS signaling cascades	0.44
Apoptosis and survival Caspase cascade	1.00	FAS pathway and Stress induction of HSP regulation	0.33
Apoptosis and survival_FAS signaling cascades	0.44

Death Receptor Signalling

	Death Receptor Signalling	1.00			Dimerization of procaspase-8	0.75
	Extrinsic Pathway for Apoptosis	1.00			Caspase-8 activation	0.75

Allograft rejection

	Allograft rejection	1.00			Graft-versus-host disease	0.63
	Type I diabetes mellitus	0.67			Autoimmune thyroid disease	0.60

Apoptosis and survival_Apoptotic TNF-family pathways

	Apoptosis and survival_Apoptotic TNF-family pathways	1.00			Apoptosis Signaling Pathways	0.35
	Apoptosis and survival Apoptotic TNF-family pathways	1.00

Transcription_Role of VDR in regulation of genes involved in osteoporosis

Transcription_Role of VDR in regulation of genes involved in osteoporosis

1.00

Transcription Role of VDR in regulation of genes involved in osteoporosis

0.80

Pathway sources
See GeneCards unified pathways
Show all pathways

5/9 EMD Millipore Pathways for FASLG (see all 9)

	Immune response CD16 signaling in NK cells
	Selected targets of GCR-alpha
	Apoptosis and survival FAS signaling cascades
	Transcription Role of VDR in regulation of genes involved in osteoporosis
	Apoptosis and survival Caspase cascade

4 R&D Systems Pathways for FASLG

	TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
	Apoptosis Signaling Pathways
	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types
	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types

2 Cell Signaling Technology (CST) Pathways for FASLG

	Apoptosis and Autophagy
	Lymphocyte Signaling

5/10 GeneGo (Thomson Reuters) Pathways for FASLG (see all 10)

	Immune response Bacterial infections in normal airways
	Apoptosis and survival Caspase cascade
	Apoptosis and survival FAS signaling cascades
	Signal transduction AKT signaling
	Transcription Role of VDR in regulation of genes involved in osteoporosis

5/15 BioSystems Pathways for FASLG (see all 15)

	Apoptosis
	Apoptosis Modulation and Signaling
	FAS pathway and Stress induction of HSP regulation
	MAPK signaling pathway
	DNA damage response (only ATM dependent)

5/6 Reactome Pathways for FASLG (see all 6)

	Death Receptor Signalling
	FasL/ CD95L signaling
	Extrinsic Pathway for Apoptosis
	Caspase-8 activation
	Dimerization of procaspase-8

5/14 Kegg Pathways (Kegg details for FASLG) (see all 14):

	MAPK signaling pathway
	Cytokine-cytokine receptor interaction
	Apoptosis
	Natural killer cell mediated cytotoxicity
	Neurotrophin signaling pathway

FASLG for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FASLG

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/128 Interacting proteins for FASLG (P48023^{1, 2, 3} ENSP00000356694⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 128)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PACSIN2	Q9UNF0²^,³, ENSP00000263246⁴	MINT-7136908 MINT-7137185 MINT-7137174 MINT-7136931 I2D: score=5 STRING: ENSP00000263246
PACSIN3	Q9UKS6²^,³, ENSP00000298838⁴	MINT-7137202 MINT-7136893 MINT-7137210 MINT-7136941 I2D: score=1 STRING: ENSP00000298838
FADD	Q13158²^,³, ENSP00000301838⁴	MINT-1956230 I2D: score=5 STRING: ENSP00000301838
CASP8	Q14790²^,³, ENSP00000351273⁴	MINT-1956272 I2D: score=4 STRING: ENSP00000351273
CASP10	Q92851²^,³, ENSP00000286186⁴	MINT-1956332 I2D: score=3 STRING: ENSP00000286186

About this table

Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA	17557115
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006915	apoptotic process	TAS	--
GO:0006917	induction of apoptosis	IDA	17076679
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	TAS	--

FASLG for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FASLG for compounds About GeneDecksing

EMD Millipore small molecules for FASLG:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FASLG
10/146 Novoseek chemical compound relationships for FASLG gene (see all 146) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
concanamycin a	61	2	19307993 (1), 10975816 (1)
dutp	60.1	6	12393527 (1), 12957613 (1), 17536279 (1), 14746617 (1) (see all 6)
ionomycin	50	35	9823934 (4), 10754388 (3), 10570264 (2), 8566027 (2) (see all 18)
sp 600125	46.1	6	19927172 (1), 17459422 (1), 18941206 (1), 17397922 (1)
cycloheximide	43.9	15	9574534 (1), 10440872 (1), 10540161 (1), 10066786 (1) (see all 9)
antalarmin	41.8	2	14644813 (1), 15032629 (1)
c-d4t	39.6	3	17180098 (1), 16212887 (1)
adpribose	38.9	3	11205313 (1), 17962376 (1), 19282377 (1)
oleandrin	37.1	2	17173971 (1), 17203245 (1)
ceramide	37.1	17	9321399 (4), 10745271 (3), 18613813 (2), 16927017 (1) (see all 9)

Search CenterWatch for drugs/clinical trials and news about FASLG / TNFL6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FASLG gene:

NM_000639.1

Unigene Cluster for FASLG:

Fas ligand (TNF superfamily, member 6)

Hs.2007 [show with all ESTs]

Unigene Representative Sequence: NM_000639

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367721(uc001gis.3) ENST00000340030(uc001git.3)

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		SwitchGear 3'UTR luciferase reporter plasmid: FASLG 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FASLG

Additional cDNA sequence:

AF288573.1 AK314874.1 AY225406.1 AY858799.1 BC017502.1 D38122.1 U08137.1 U11821.1

X89102.1

1 DOTS entry:

DT.309278

14 AceView cDNA sequences:

NM_000639 BC017502 X89102 AY225406 U08137 AF288573 D38122 BG744522

BX283930 U11821 BP377614 BG745161 AA361832 BI824995

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FASLG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAATAAAAAG

About this image

FASLG expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Placenta

Extravillous Cytotrophoblast Layer

Extravillous Cytotrophoblast Cells

Extraembryonic Tissues, Placenta

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Natural killer-like cells (Derivation of hemato...)

See FASLG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FASLG

SOURCE GeneReport for Unigene cluster: Hs.2007

SABiosciences Expression via Pathway-Focused PCR Arrays including FASLG (see all 26):

Multiple Sclerosis in human mouse rat

Cancer PathwayFinder in human mouse rat

T-cell & B-cell Activation in human mouse rat

Endothelial Cell Biology in human mouse rat

Neurotoxicity in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FASLG

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FASLG gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FASLG¹	Fas ligand (TNF superfamily, member 6)	62.06(n) 55.34(a)		429064 NM_001031559.1 NP_001026730.1
lizard (Anolis carolinensis)	Reptilia	FASLG⁶	--	48(a)	1 ↔ 1	GL343300.1(1381931-1386261)
zebrafish (Danio rerio)	Actinopterygii	faslg¹	Fas ligand (TNF superfamily, member 6)	49.33(n) 36(a)		735295 NM_001042701.2 NP_001036166.1

ENSEMBL Gene Tree for FASLG (if available)
TreeFam Gene Tree for FASLG (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for FASLG gene

TNFSF15² LTA² TNFSF14² TNF²

1 SIMAP similar gene for FASLG using alignment to 3 protein entries: TNFL6_HUMAN (see all proteins):

TNF

FASLG for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112375045^1,2		--	143850810(+)	`GGGGGG/CCAGTA`	1	--	us2k¹		1		CSA	2
rs41309788^1,2	C,F,	--	143851000(+)	`TAGTAC/TCCTTG`	1	--	us2k¹		1		WA	118
rs16844867^1,2	C,F,	--	143851075(+)	`AAAACT/CAACGA`	1	--	us2k¹ tfbs³		5		NA WA	262
rs12080307^1,2	C	--	143851578(+)	`ACCCAG/AAACTC`	1	--	us2k¹		1		NA	2
rs111378518^1,2	C,	--	143851737(+)	`TTTTTA/TATGTT`	1	--	us2k¹		0	--	--	--	--
rs77427795^1,2	C,F,	--	143851747(+)	`TGATAT/CTAAAA`	1	--	us2k¹		1		NA	120
rs113526183^1,2	C,	--	143851823(+)	`GGAGGC/ATGTCT`	1	--	us2k¹		1		WA	2
rs2021837^1,2	C,F,A,H,	--	143852196(-)	`CATAAT/CTTACA`	1	--	us2k¹		6		NS EA WA CSA	406
rs12720438^1,2	C	--	143852255(+)	`ATGGCA/CACAGA`	1	--	us2k¹		2		NA	4
rs41309790^1,2	C,F,	--	143852474(+)	`TAAAAA/TAGCAT`	1	--	us2k¹		1		NA	120

HapMap Linkage Disequilibrium report for FASLG (172628154 - 172636014 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FASLG: --
Human Gene Mutation Database (HGMD): FASLG

Locus Specific Mutation Databases (LSDB): FASLG

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FASLG

DNA2.0 Custom Variant and Variant Library Synthesis for FASLG

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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FASLG for disorders           About GeneDecksing

OMIM gene information: 134638
OMIM disorders: 152700
UniProtKB/Swiss-Prot: TNFL6_HUMAN, P48023

Defects in FASLG are the cause of autoimmune lymphoproliferative syndrome type 1B (ALPS1B) [MIM:601859]; also

known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia

with massive lymphadenopathy and splenomegaly

20/243 diseases for FASLG (see all 243): About MalaCards

systemic lupus erythematosus htlv-1 associated myelopathy/tropical spastic paraparesis vogt-koyanagi-harada disease lupus erythematosus

htlv-1 associated myelopathy toxic epidermal necrolysis stevens-johnson syndrome graft versus host disease

tropical spastic paraparesis lymphomatoid papulosis nontoxic goiter adult-onset still's disease

sertoli cell-only syndrome b-cell non-hodgkin lymphoma lumbar disc degeneration diffuse large b-cell lymphoma

spastic paraparesis hypersensitivity reaction type ii disease acute graft versus host disease non-hodgkin lymphoma

7 diseases from the University of Copenhagen DISEASES database for FASLG:

Cancer Hypersensitivity reaction type II disease Autoimmune lymphoproliferative syndrome Hepatitis

Thyroiditis Stevens-Johnson syndrome Vascular disease

10/95 Novoseek disease relationships for FASLG gene (see all 95) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
autoimmune lymphoproliferative syndrome	72.6	5	10672498 (1), 19176318 (1), 8787672 (1), 17062728 (1)
necrosis	72.1	260	8996241 (2), 11422744 (2), 18314443 (2), 11384965 (2) (see all 99)
tumors	70.7	953	15585624 (8), 14515265 (7), 14766381 (6), 12949796 (6) (see all 99)
tumor escape	66.9	8	15968727 (1), 10586378 (1), 10652626 (1), 11523216 (1) (see all 8)
leukemia lymphocytic large granular	61.7	2	10652626 (1), 10492090 (1)
toxic epidermal necrolysis	61.1	2	11799383 (1), 17977827 (1)
hashimotos thyroiditis	55.3	27	12559631 (4), 9396343 (3), 16219172 (2), 17558708 (2) (see all 16)
autoimmune diseases	53.2	22	7533498 (2), 10548879 (1), 14555216 (1), 18361934 (1) (see all 18)
stevens-johnson syndrome	52.7	1	11799383 (1)
cancer	51.4	166	12854132 (5), 11927015 (4), 14680559 (4), 10817504 (3) (see all 99)

GeneTests: FASLG

Autoimmune Lymphoproliferative Syndrome

Genetic Association Database (GAD): FASLG
Human Genome Epidemiology (HuGE) Navigator: FASLG (99 documents)

Export disorders for FASLG gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for FASLG gene, integrated from 9 sources (see all 1884):
(articles sorted by number of sources associating them with FASLG)

Utopia: connect your pdf to the dynamic
world of online information

Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease. (PubMed id 8787672)^{1, 2, 4, 9} Wu J.... Mountz J.D. (1996)
Human Fas ligand: gene structure, chromosomal location and species specificity. (PubMed id 7826947)^{1, 2, 3, 9} Takahashi T.... Nagata S. (1994)
The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells. (PubMed id 17557115)^{1, 2, 9} Kirkin V....Zornig M. (2007)
Genetic polymorphisms of Fas (CD95) and Fas ligand (CD178) influence the rise in CD4+ T cell count after antiretroviral therapy in drug-naive HIV-positive patients. (PubMed id 16158329)^{1, 4, 9} Nasi M....Cossarizza A. (2005)
Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation. (PubMed id 17164290)^{1, 2, 9} Zuccato E....Griffiths G.M. (2007)
The -844C/T polymorphism in the Fas ligand promoter associates with Taiwanese SLE. (PubMed id 15674374)^{1, 4, 9} Chen J.Y....Luo S.F. (2005)
Fas ligand gene polymorphisms are not associated with Hashimoto's thyroiditis and Graves' disease. (PubMed id 12559631)^{1, 4, 9} Stuck B.J....Badenhoop K. (2003)
Fas and Fas ligand gene polymorphisms in primary Sjogren's syndrome. (PubMed id 11036836)^{1, 4, 9} Bolstad A.I....Jonsson R. (2000)
Characterization of Fas (Apo-1, CD95)-Fas ligand interaction. (PubMed id 9228058)^{1, 2, 9} Schneider P.... Tschopp J. (1997)
Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)^{1, 2} Voss M....Janssen O. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 356	HGNC: 11936	AceView: TNFSF6	Ensembl:ENSG00000117560	euGenes: HUgn356
ECgene: FASLG	Kegg: 356	H-InvDB: FASLG

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for FASLG	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FASLG	Genetics and Cytogenetics in Oncology and Haematology
FASLGbase	http://bioinf.uta.fi/FASLGbase/
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/FASLG
Wikipedia	http://en.wikipedia.org/wiki/FAS_ligand

Intellectual Property for FASLG gene
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Patent Information for FASLG gene:
Search GeneIP for patents involving FASLG

GeneCards and IP:
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FASLG Gene

Fas ligand (TNF superfamily, member 6)

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Leukemia B-Cell
Leukemia T-Cell
Acantholysis
Hepatitis Chronic
immunopathology
Carcinoma Basal Cell
Lymphoma T-Cell
aggressiveness
COLON CARCINOMA
Paraparesis Tropical Spastic
Sjogrens Syndrome Primary
Carcinoma Pancreatic Ductal
Adenocarcinoma
cell damage
Cancer
Colorectal Carcinoma
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ADENOCARCINOMA GASTRIC
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Lymphomatoid Papulosis
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virus infection
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FIBROSIS IDIOPATHIC PULMONARY
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FASLG Gene

Fas ligand (TNF superfamily, member 6)

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