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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FASLG Gene

protein-coding   GIFtS: 66
GCID: GC01P172628

Fas Ligand (TNF Superfamily, Member 6)

(Previous names: tumor necrosis factor (ligand) superfamily, member 6)
(Previous symbols: APT1LG1, TNFSF6)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fas Ligand (TNF Superfamily, Member 6)1 2     CD95L2 3
APT1LG11 2 3 5     CD95 Ligand2 3
TNFSF61 2 3 5     ALPS1B2
FASL2 3 5     CD1782
Tumor Necrosis Factor (Ligand) Superfamily, Member 61 2     Apoptosis (APO-1) Antigen Ligand 12
Apoptosis Antigen Ligand2 3     Tumor Necrosis Factor Ligand Superfamily Member 62
Fas Antigen Ligand2 3     FasL3
APTL2 3     CD178 Antigen3
CD95-L2 3     Fas Ligand3

External Ids:    HGNC: 119361   Entrez Gene: 3562   Ensembl: ENSG000001175607   OMIM: 1346385   UniProtKB: P480233   

Export aliases for FASLG gene to outside databases

Previous GC identifers: GC01P169360 GC01P170894 GC01P143852


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FASLG Gene:
The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with
this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene
may be related to some cases of systemic lupus erythematosus (SLE). (provided by RefSeq, Jul 2008)

GeneCards Summary for FASLG Gene: 
FASLG (Fas ligand (TNF superfamily, member 6)) is a protein-coding gene. Diseases associated with FASLG include toxic epidermal necrolysis, and lyell syndrome, and among its related super-pathways are TNF Signaling and Apoptosis and survival FAS signaling cascades. GO annotations related to this gene include tumor necrosis factor receptor binding and receptor binding. An important paralog of this gene is TNFSF15.

UniProtKB/Swiss-Prot: TNFL6_HUMAN, P48023
Function: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be
involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may
have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or
both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects
Function: The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition

Gene Wiki entry for FASLG (Fas ligand) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FASLG gene promoter:
         GR   Sp1   Meis-1b   FOXO1a   GR-alpha   Meis-1a   FOXO1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FASLG promoter sequence
   Search SABiosciences Chromatin IP Primers for FASLG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FASLG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23   Ensembl cytogenetic band:  1q24.3   HGNC cytogenetic band: 1q23

FASLG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FASLG gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P172628:  view genomic region     (about GC identifiers)

Start:
172,628,154 bp from pter      End:
172,636,014 bp from pter
Size:
7,861 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TNFL6_HUMAN, P48023 (See protein sequence)
Recommended Name: Tumor necrosis factor ligand superfamily member 6  
Size: 281 amino acids; 31485 Da
Subunit: Homotrimer (Probable). Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4,
EPS8L3, FGR, FYB, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1,
PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC,
SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1
Subcellular location: Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle lumen. Lysosome
lumen. Note=Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and
monoubiquitination. Colocalizes with the SPPL2A protease at the cell membrane
Subcellular location: Tumor necrosis factor ligand superfamily member 6, soluble form: Secreted (By similarity).
Note=May be released into the extracellular fluid, probably by cleavage form the cell surface (By similarity)
Subcellular location: FasL intracellular domain: Nucleus. Note=The FasL ICD cytoplasmic form is translocated into
the nucleus
1 PDB 3D structure from and Proteopedia for FASLG:
1BZI (3D)    
Secondary accessions: Q9BZP9
Alternative splicing: 2 isoforms:  P48023-1   P48023-2   

Explore the universe of human proteins at neXtProt for FASLG: NX_P48023

Explore proteomics data for FASLG at MOPED 

Post-translational modifications:

  • UniProtKB: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form undergoes two
    successive intramembrane proteolytic cleavages. The first one is processed by ADAM10 producing an N-terminal
    fragment, which lacks the receptor-binding extracellular domain. This ADAM10-processed FasL (FasL APL) remnant
    form is still membrane anchored and further processed by SPPL2A that liberates the FasL intracellular domain
    (FasL ICD). FasL shedding by ADAM10 is a prerequisite for subsequent intramembrane cleavage by SPPL2A in T-cells
  • UniProtKB: N-glycosylated
  • UniProtKB: Phosphorylated by FGR on tyrosine residues; this is required for ubiquitination and subsequent internalization
  • UniProtKB: Monoubiquitinated
  • View neXtProt modification sites for NX_P48023

  • FASLG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FASLG Protein Expression
    REFSEQ proteins: NP_000630.1  
    ENSEMBL proteins: 
     ENSP00000356694   ENSP00000344739  
    Reactome Protein details: P48023
    Human Recombinant Protein Products for FASLG: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for FASLG (Fas Ligand/TNFSF6)
    Enzo Life Sciences proteins for FASLG
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FASLG
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for FASLG
    GenScript Custom Purified and Recombinant Proteins Services for FASLG
    Novus Biologicals FASLG Proteins
    Novus Biologicals FASLG Lysates
    Sino Biological Recombinant Protein for FASLG
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for FASLG
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA18835034
    GO:0005634nucleus IDA17557115
    GO:0005887integral to plasma membrane TAS7826947
    GO:0005901caveola IEA--

    FASLG for ontologies           About GeneDecksing



    FASLG Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of FASLG
    R&D Systems Antibodies for FASLG (Fas Ligand/TNFSF6)
    Cell Signaling Technology (CST) Antibodies for FASLG  (FasL)
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    GenScript Custom Superior Antibodies Services for FASLG
    Novus Biologicals FASLG Antibodies
    Abcam antibodies for FASLG
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for FASLG
    LSBio Antibodies in human, mouse, rat for FASLG 

    Assay Products for FASLG: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FASLG
    R&D Systems ELISAs for FASLG (Fas Ligand/TNFSF6)         (see all)
    GenScript Custom Assay Services for FASLG
    Enzo Life Sciences assays for FASLG
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    TNFSF: Tumor necrosis factor (ligand) superfamily

    5 InterPro protein domains:
     IPR021184 TNF_CS
     IPR008064 Fas_ligand
     IPR006052 TNF
     IPR006053 TNF_a/b/c
     IPR008983 Tumour_necrosis_fac-like_dom

    Graphical View of Domain Structure for InterPro Entry P48023

    ProtoNet protein and cluster: P48023

    3 Blocks protein domains:
    IPB006052 Tumor Necrosis Factor
    IPB006053 Tumour necrosis factor family signature
    IPB008064 Fas antigen ligand signature


    UniProtKB/Swiss-Prot: TNFL6_HUMAN, P48023
    Similarity: Belongs to the tumor necrosis factor family


    FASLG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNFL6_HUMAN, P48023
    Function: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be
    involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may
    have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or
    both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects
    Function: The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS7826947
    GO:0005125cytokine activity IEA--
    GO:0005164tumor necrosis factor receptor binding IEA--
    GO:0005515protein binding IPI12198154
         
    FASLG for ontologies           About GeneDecksing


    Phenotypes:
         15/18 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Fasl) (see all 18):
     cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     nervous system  normal  renal/urinary system  reproductive system  respiratory system 

    FASLG for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FASLG: Fasltm1.1Bksa Fasltm1.1Lest

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FASLG 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FASLG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FASLG 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FASLG 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FASLG
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate FASLG (see all 14):
    hsa-miR-98 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-3653 hsa-let-7i hsa-miR-21 hsa-let-7e
    SwitchGear 3'UTR luciferase reporter plasmidFASLG 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FASLG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FASLG

    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of FASLG

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for FASLG (see all 8)
    OriGene ORF clones in mouse, rat for FASLG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FASLG (NM_000639)
    Sino Biological Human cDNA Clone for FASLG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FASLG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FASLG
    Sirion Biotech Customized lentivirus for stable overexpression of FASLG 
                         Customized lentivirus expression plasmids for stable overexpression of FASLG 

    Cell Line
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    Search LifeMap BioReagents cell lines for FASLG
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FASLG


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FASLG About   (see all 38)                                                                                              See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    2Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades0.44
    FAS pathway and Stress induction of HSP regulation0.44
    Apoptosis and survival Caspase cascade0.44
    3MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    4Apoptosis and survival Apoptotic TNF-family pathways
    Apoptosis and survival Apoptotic TNF-family pathways0.35
    Apoptosis Signaling Pathways0.35
    5Immune response Fc epsilon RI pathway
    Immune response CD16 signaling in NK cells0.32
    Natural killer cell mediated cytotoxicity0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/9 EMD Millipore Pathways for FASLG (see all 9)
        Immune response CD16 signaling in NK cells
    Selected targets of GCR-alpha
    Apoptosis and survival FAS signaling cascades
    Transcription Role of VDR in regulation of genes involved in osteoporosis
    Apoptosis and survival Caspase cascade

    4 R&D Systems Pathways for FASLG
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
    Apoptosis Signaling Pathways
    IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types


    2 Cell Signaling Technology (CST) Pathways for FASLG
        Apoptosis and Autophagy
    Lymphocyte Signaling

    5/10 GeneGo (Thomson Reuters) Pathways for FASLG (see all 10)
        Immune response Bacterial infections in normal airways
    Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades
    Signal transduction AKT signaling
    Transcription Role of VDR in regulation of genes involved in osteoporosis

    5/14 BioSystems Pathways for FASLG (see all 14)
        MAPK signaling pathway
    Apoptosis
    Apoptosis Modulation and Signaling
    DNA damage response (only ATM dependent)
    FAS pathway and Stress induction of HSP regulation

    3 Sino Biological Pathways for FASLG 
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway

    5/7        Reactome Pathways for FASLG (see all 7)
        Death Receptor Signalling
    FasL/ CD95L signaling
    Extrinsic Pathway for Apoptosis
    Caspase-8 activation
    Dimerization of procaspase-8


    5/19         Kegg Pathways  (Kegg details for FASLG) (see all 19):
        MAPK signaling pathway
    Cytokine-cytokine receptor interaction
    PI3K-Akt signaling pathway
    Apoptosis
    Natural killer cell mediated cytotoxicity


    FASLG for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FASLG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/134 Interacting proteins for FASLG (P480231, 2, 3 ENSP000003566944) via UniProtKB, MINT, STRING, and/or I2D (see all 134)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PACSIN2Q9UNF02, 3, ENSP000002632464MINT-7136908 MINT-7137185 MINT-7137174 MINT-7136931 I2D: score=5 STRING: ENSP00000263246
    PACSIN3Q9UKS62, 3, ENSP000002988384MINT-7137202 MINT-7136893 MINT-7137210 MINT-7136941 I2D: score=1 STRING: ENSP00000298838
    FADDQ131582, 3, ENSP000003018384MINT-1956230 I2D: score=5 STRING: ENSP00000301838
    CASP8Q147902, 3, ENSP000003512734MINT-1956272 I2D: score=4 STRING: ENSP00000351273
    CASP10Q928512, 3, ENSP000002861864MINT-1956332 I2D: score=3 STRING: ENSP00000286186
    About this table

    Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA17557115
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006915apoptotic process TAS--
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process TAS--
    GO:0006925inflammatory cell apoptotic process IEA--

    FASLG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FASLG for compounds           About GeneDecksing

    EMD Millipore small molecules for FASLG:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FASLG (TNFL6)

    10/146 Novoseek inferred chemical compound relationships for FASLG gene (see all 146)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    concanamycin a 61 2 19307993 (1), 10975816 (1)
    dutp 60.1 6 12393527 (1), 12957613 (1), 17536279 (1), 14746617 (1) (see all 6)
    ionomycin 50 35 9823934 (4), 10754388 (3), 10570264 (2), 8566027 (2) (see all 18)
    sp 600125 46.1 6 19927172 (1), 17459422 (1), 18941206 (1), 17397922 (1)
    cycloheximide 43.9 15 9574534 (1), 10440872 (1), 10540161 (1), 10066786 (1) (see all 9)
    antalarmin 41.8 2 14644813 (1), 15032629 (1)
    c-d4t 39.6 3 17180098 (1), 16212887 (1)
    adpribose 38.9 3 11205313 (1), 17962376 (1), 19282377 (1)
    oleandrin 37.1 2 17173971 (1), 17203245 (1)
    ceramide 37.1 17 9321399 (4), 10745271 (3), 18613813 (2), 16927017 (1) (see all 9)

    Search CenterWatch for drugs/clinical trials and news about FASLG / TNFL6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FASLG gene: 
    NM_000639.1  

    Unigene Cluster for FASLG:

    Fas ligand (TNF superfamily, member 6)
    Hs.2007  [show with all ESTs]
    Unigene Representative Sequence: NM_000639
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367721(uc001gis.3) ENST00000340030(uc001git.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate FASLG (see all 14):
    hsa-miR-98 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-3653 hsa-let-7i hsa-miR-21 hsa-let-7e
    SwitchGear 3'UTR luciferase reporter plasmidFASLG 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: FASLG (NM_000639)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FASLG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FASLG
    Sirion Biotech Customized lentivirus for stable overexpression of FASLG 
                         Customized lentivirus expression plasmids for stable overexpression of FASLG 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FASLG
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FASLG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FASLG

    Additional mRNA sequence: 

    AF288573.1 AK314874.1 AY225406.1 AY858799.1 BC017502.1 D38122.1 U08137.1 U11821.1 
    X89102.1 

    1 DOTS entry:

    DT.309278 

    14 AceView cDNA sequences:

    X89102 NM_000639 U08137 BC017502 AY225406 U11821 D38122 BP377614 
    AF288573 BX283930 BG744522 BG745161 AA361832 BI824995 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FASLG expression in normal human tissues (normalized intensities)      FASLG embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATAAAAAG
    FASLG Expression
    About this image


    FASLG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Natural Killer Cells Peripheral Blood
             Natural killer-like cells ( Derivation of hematopoietic progenitor cells and natural...
             nk cells   
     
     Placenta (Extraembryonic Tissues)
             Extravillous Cytotrophoblast Cells Extravillous Cytotrophoblast Layer
     
     Spleen (Hematopoietic System)
             splenocytes   

    See FASLG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FASLG

    SOURCE GeneReport for Unigene cluster: Hs.2007
        SABiosciences Expression via Pathway-Focused PCR Arrays including FASLG (see all 26): 
              Multiple Sclerosis in human mouse rat
              Cancer PathwayFinder in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Neurotoxicity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FASLG gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fasl1 , 5 Fas ligand (TNF superfamily, member 6)1, 5 84.05(n)1
    78.42(a)1
      1 (69.95 cM)5
    141031  NM_010177.41  NP_034307.11 
     1617806915 
    chicken
    (Gallus gallus)
    Aves FASLG1 Fas ligand (TNF superfamily, member 6) 62.06(n)
    55.34(a)
      429064  NM_001031559.1  NP_001026730.1 
    lizard
    (Anolis carolinensis)
    Reptilia FASLG6
    Uncharacterized protein
    48(a)
    1 ↔ 1
    GL343300.1(1381150-1388978)
    zebrafish
    (Danio rerio)
    Actinopterygii faslg1 Fas ligand (TNF superfamily, member 6) 49.33(n)
    36(a)
      735295  NM_001042701.2  NP_001036166.1 


    ENSEMBL Gene Tree for FASLG (if available)
    TreeFam Gene Tree for FASLG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FASLG gene
    TNFSF152  LTA2  TNFSF142  TNF2  
    1 SIMAP similar gene for FASLG using alignment to 3 protein entries:     TNFL6_HUMAN (see all proteins):
    TNF

    FASLG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/248 SNPs in FASLG are shown (see all 248)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs7631101,2
    C,F,A,Hpathogenic1179180467(+) CATTGT/CGAAAT 1 -- us2k121Minor allele frequency- C:0.46NS EA NA WA CSA 2336
    rs803582381,2
    Cpathogenic1179187744(+) ACTCAA/GGGTCC 2 R G mis10--------
    rs97872481,2
    C--143851277(+) ACTACA/CAAAAA 1 -- us2k11Minor allele frequency- C:0.00WA 2
    rs113243071,2
    C--143859199(+) ACGTT-/GTTGAG 1 -- int11Minor allele frequency- G:0.00CSA 2
    rs1119588721,2
    F--143859199(+) ACGTTG/TTTGAG 1 -- int12Minor allele frequency- T:0.50CSA 4
    rs106405131,2
    C--143860366(+) TAGGg-/GTgtgtg 1 -- ut310--------
    rs359355231,2
    C--143860367(+) AGGGG-/GTTGTGT 1 -- ut310--------
    rs1123750451,2
    C,F--179179155(+) GGGGGG/CCAGTA 1 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs1456932441,2
    C--179179155(+) GGGGG-/CCAGTA 1 -- us2k10--------
    rs1876356091,2
    --179179187(+) CAGGTA/CTCAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FASLG (172628154 - 172636014 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FASLG: --

    Human Gene Mutation Database (HGMD): FASLG

    Locus Specific Mutation Databases (LSDB): FASLG
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FASLG
    DNA2.0 Custom Variant and Variant Library Synthesis for FASLG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 134638   
    OMIM disorders: 152700  
    UniProtKB/Swiss-Prot: TNFL6_HUMAN, P48023
  • Autoimmune lymphoproliferative syndrome 1B (ALPS1B) [MIM:601859]: A disorder of apoptosis that manifests
    in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by
    non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and
    neutropenia. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20/226 diseases for FASLG (see all 226):    About MalaCards
    toxic epidermal necrolysis    lyell syndrome    faslg-related autoimmune lymphoproliferative syndrome    silicosis
    type ii mixed cryoglobulinemia    autoimmune lymphoproliferative syndrome    htlv-1 associated myelopathy    idiopathic anterior uveitis
    htlv-1 associated myelopathy/tropical spastic paraparesis    acute t cell leukemia    tropical spastic paraparesis    vogt-koyanagi-harada disease
    graft versus host disease    stevens-johnson syndrome    epstein-barr virus-associated gastric carcinoma    cytomegalovirus retinitis
    nontoxic goiter    spastic paraparesis    lumbar disc degeneration    lymphomatoid papulosis

    8 diseases from the University of Copenhagen DISEASES database for FASLG:
    Cancer     Hypersensitivity reaction type II disease     Autoimmune lymphoproliferative syndrome     Hepatitis
    Thyroiditis     Stevens-Johnson syndrome     Vascular disease     Human immunodeficiency virus infectious disease

    FASLG for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/95 Novoseek inferred disease relationships for FASLG gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune lymphoproliferative syndrome 72.6 5 10672498 (1), 19176318 (1), 8787672 (1), 17062728 (1)
    necrosis 72.1 260 8996241 (2), 11422744 (2), 18314443 (2), 11384965 (2) (see all 99)
    tumors 70.7 953 15585624 (8), 14515265 (7), 14766381 (6), 12949796 (6) (see all 99)
    tumor escape 66.9 8 15968727 (1), 10586378 (1), 10652626 (1), 11523216 (1) (see all 8)
    leukemia lymphocytic large granular 61.7 2 10652626 (1), 10492090 (1)
    toxic epidermal necrolysis 61.1 2 11799383 (1), 17977827 (1)
    hashimotos thyroiditis 55.3 27 12559631 (4), 9396343 (3), 16219172 (2), 17558708 (2) (see all 16)
    autoimmune diseases 53.2 22 7533498 (2), 10548879 (1), 14555216 (1), 18361934 (1) (see all 18)
    stevens-johnson syndrome 52.7 1 11799383 (1)
    cancer 51.4 166 12854132 (5), 11927015 (4), 14680559 (4), 10817504 (3) (see all 99)

    GeneTests: FASLG
    GeneReviews: FASLG
    Genetic Association Database (GAD): FASLG
    Human Genome Epidemiology (HuGE) Navigator: FASLG (99 documents)

    Export disorders for FASLG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FASLG gene, integrated from 9 sources (see all 1916):
    (articles sorted by number of sources associating them with FASLG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease. (PubMed id 8787672)1, 2, 4, 9 Wu J.... Mountz J.D. (1996)
    2. Human Fas ligand: gene structure, chromosomal location and species specificity. (PubMed id 7826947)1, 2, 3, 9 Takahashi T.... Nagata S. (1994)
    3. Study of Fas (CD95) and FasL (CD178) polymorphisms in liver transplant recipients. (PubMed id 16441482)1, 4, 9 Marin L.A....Alvarez-Lopez M.R. (2006)
    4. The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells. (PubMed id 17557115)1, 2, 9 Kirkin V....Zornig M. (2007)
    5. Genetic polymorphisms of Fas (CD95) and Fas ligand (CD178) influence the rise in CD4+ T cell count after antiretroviral therapy in drug-naive HIV-positive patients. (PubMed id 16158329)1, 4, 9 Nasi M....Cossarizza A. (2005)
    6. Prognostic significance of the Fas-receptor/Fas-ligand system in cervical squamous cell carcinoma. (PubMed id 18000680)1, 4, 9 Lerma E....Prat J. (2008)
    7. Functional variants in cell death pathway genes and risk of pancreatic cancer. (PubMed id 18483392)1, 4, 9 Yang M....Lin D. (2008)
    8. FAS and FAS ligand polymorphisms in the promoter regi ons and risk of gastric cancer in Southern China. (PubMed id 19565204)1, 4, 9 Wang M....Zhang Z. (2009)
    9. The -509C/T polymorphism of transforming growth facto r-beta1 is associated with increased risk for development of chronic idiopathic neutropenia. (PubMed id 19614955)1, 4, 9 Eliopoulos D.G....Papadaki H.A. (2009)
    10. Genetic polymorphisms of IL-1A, IL-1B, IL-1RN, NFKB1, FAS, and FASL, and risk of silicosis in a Chinese occupational population. (PubMed id 18666137)1, 4, 9 Wu F....Christiani D.C. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 356 HGNC: 11936 AceView: TNFSF6 Ensembl:ENSG00000117560 euGenes: HUgn356
    ECgene: FASLG Kegg: 356 H-InvDB: FASLG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FASLG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FASLG Genetics and Cytogenetics in Oncology and Haematology
    FASLGbasehttp://bioinf.uta.fi/FASLGbase/
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/FASLG
    Wikipedia http://en.wikipedia.org/wiki/FAS_ligand

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FASLG gene:
    Search GeneIP for patents involving FASLG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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