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FAS Gene

protein-coding   GIFtS: 72
GCID: GC10P090741

Fas Cell Surface Death Receptor

(Previous names: tumor necrosis factor receptor superfamily, member 6, Fas...)
(Previous symbols: FAS1, APT1, TNFRSF6)
  See FAS-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fas Cell Surface Death Receptor1 2     CD952 5
APT11 2 3 5     APO-12
TNFRSF61 2 3 5     FASTM2
FAS11 2 3     APO-1 Cell Surface Antigen2
Fas (TNF Receptor Superfamily, Member 6)1 2     Apoptosis Antigen 12
Tumor Necrosis Factor Receptor Superfamily, Member 61 2     Delta Fas/APO-1/CD952
TNF Receptor Superfamily Member 61 2     FAS 827dupA2
Apoptosis-Mediating Surface Antigen FAS2 3     Fas AMA2
CD95 Antigen2 3     FAS Receptor Variant 92
FASLG Receptor2 3     Tumor Necrosis Factor Receptor Superfamily Member 62
ALPS1A2 5     Apo-1 Antigen3

External Ids:    HGNC: 119201   Entrez Gene: 3552   Ensembl: ENSG000000261037   OMIM: 1346375   UniProtKB: P254453   

Export aliases for FAS gene to outside databases

Previous GC identifer: GC10P084384


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FAS Gene:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death
domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and
has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The
interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that
includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of
the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been
also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the
proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants
have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking
the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. (provided by
RefSeq, Mar 2011)

GeneCards Summary for FAS Gene:
FAS (Fas cell surface death receptor) is a protein-coding gene. Diseases associated with FAS include burn scar, and squamous cell carcinoma, burn scar-related, somatic. GO annotations related to this gene include receptor activity and identical protein binding.

UniProtKB/Swiss-Prot: TNR6_HUMAN, P25445
Function: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The
resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the
subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated
apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature
T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro)

Gene Wiki entry for FAS (Fas receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAS gene promoter:
         STAT1   AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FAS promoter sequence
   Search Chromatin IP Primers for FAS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.1   Ensembl cytogenetic band:  10q23.31   HGNC cytogenetic band: 10q24.1

FAS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAS gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P090741:  view genomic region     (about GC identifiers)

Start:
90,750,288 bp from pter      End:
90,775,542 bp from pter
Size:
25,255 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for FAS

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TNR6_HUMAN, P25445 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 6 precursor  
Size: 335 amino acids; 37732 Da
Subunit: Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD (By similarity). Binds
RIPK1 and FAIM2. Interacts with BRE and FEM1B. Interacts with FADD
6 PDB 3D structures from and Proteopedia for FAS:
1BZI (3D)        1DDF (3D)        3EWT (3D)        3EZQ (3D)        3THM (3D)        3TJE (3D)    
Secondary accessions: A9UJX4 B6VNV4 Q14292 Q14293 Q14294 Q14295 Q16652 Q5T9P1 Q5T9P2 Q5T9P3
Q6SSE9
Alternative splicing: 7 isoforms:  P25445-1   P25445-2   P25445-3   P25445-4   P25445-5   P25445-6   P25445-7   (Dominant negative isoform, resistant to Fas-mediated apoptosis)

Explore the universe of human proteins at neXtProt for FAS: NX_P25445

Explore proteomics data for FAS at MOPED

Post-translational modifications: 

  • N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans1
  • Glycosylation2 at Thr28, Thr40, Thr42, Thr43, Thr46, Asn118, Asn136
  • Modification sites at PhosphoSitePlus

  • See FAS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_000034.1  NP_690610.1  NP_690611.1  

    ENSEMBL proteins: 
     ENSP00000347979   ENSP00000345601   ENSP00000420975   ENSP00000349896   ENSP00000425159  
     ENSP00000423755   ENSP00000424113   ENSP00000422453   ENSP00000347426  
    Reactome Protein details: P25445

    FAS Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant FAS Protein
    R&D Systems Recombinant & Natural Proteins for FAS (Fas/TNFRSF6/CD95)
    Enzo Life Sciences proteins for FAS
    OriGene Purified Protein for FAS
    OriGene Protein Over-expression Lysate for FAS
    OriGene MassSpec for FAS
    OriGene Custom Protein Services for FAS
    GenScript Custom Purified and Recombinant Proteins Services for FAS
    Novus Biologicals FAS Proteins
    Novus Biologicals FAS Lysates
    Sino Biological Recombinant Protein for FAS
    Sino Biological Cell Lysate for FAS
    ProSpec Recombinant Protein for FAS
    Cloud-Clone Corp. Proteins for FAS

     
    eBioscience Proteins for FAS:  
                        Recombinant Human sAPO-1/Fas 50 ug

     
    antibodies-online proteins for FAS (44 products) 

     
    antibodies-online peptides for FAS

    FAS Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of FAS
    R&D Systems Antibodies for FAS (Fas/TNFRSF6/CD95)
    Cell Signaling Technology (CST) Antibodies for FAS 
    OriGene Antibodies for FAS
    OriGene Custom Antibody Services for FAS
    Novus Biologicals FAS Antibodies
    Abcam antibodies for FAS
    Cloud-Clone Corp. Antibodies for FAS
    ThermoFisher Antibody for FAS
    LSBio Antibodies in human, mouse, rat for FAS
    antibodies-online antibodies for FAS (524 products) 

    FAS Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FAS
    R&D Systems ELISAs for FAS (Fas/TNFRSF6/CD95)         (see all)
    GenScript Custom Assay Services for FAS
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FAS
    Cloud-Clone Corp. CLIAs for FAS
    eBioscience ELISAs for FAS: (see all 2
                        Human sAPO-1/Fas Platinum ELISA 96 tests
    antibodies-online kits for FAS (47 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: Fas
    Tumour necrosis factor (TNF) receptor family

    4 InterPro protein domains:
     IPR011029 DEATH-like_dom
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR008063 Fas_rcpt
     IPR000488 Death_domain

    Graphical View of Domain Structure for InterPro Entry P25445

    ProtoNet protein and cluster: P25445

    3 Blocks protein domains:
    IPB000488 Death domain
    IPB001368 TNFR/CD27/30/40/95 cysteine-rich region
    IPB008063 FAS/CD95 receptor family signature


    UniProtKB/Swiss-Prot: TNR6_HUMAN, P25445
    Domain: Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins
    Similarity: Contains 1 death domain
    Similarity: Contains 3 TNFR-Cys repeats


    Find genes that share domains with FAS           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNR6_HUMAN, P25445
    Function: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The
    resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the
    subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated
    apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature
    T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity TAS10875918
    GO:0004872receptor activity NAS7533181
    GO:0004888transmembrane signaling receptor activity IEA--
    GO:0005515protein binding IPI10918185
    GO:0019900kinase binding IPI7538908
         
    Find genes that share ontologies with FAS           About GenesLikeMe


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 9 alleles(MGI details for Fas) (see all 23):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  liver/biliary system  mortality/aging 

    Find genes that share phenotypes with FAS           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FAS: Fastm1Dlo Fastm1.1Cgn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAS
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FAS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAS
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAS

    miRNA
    Products:
        
    miRTarBase miRNAs that target FAS:
    hsa-mir-504-5p (MIRT016252), hsa-mir-98-5p (MIRT027598), hsa-mir-146a-5p (MIRT005581), hsa-mir-21-5p (MIRT002421), hsa-mir-106a-5p (MIRT006331)

    Block miRNA regulation of human, mouse, rat FAS using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAS (see all 17):
    hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-374c hsa-let-7g hsa-let-7a hsa-miR-23a hsa-miR-98
    SwitchGear 3'UTR luciferase reporter plasmidFAS 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FAS
    Predesigned siRNA for gene silencing in human, mouse, rat FAS

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FAS

    Clone
    Products:
         
    OriGene clones in human, mouse for FAS (see all 22)
    OriGene ORF clones in mouse, rat for FAS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): FAS (NM_000043)
    Sino Biological Human cDNA Clone for FAS
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAS

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FAS
    Browse ESI BIO Cell Lines and PureStem Progenitors for FAS 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TNR6_HUMAN, P25445: Isoform 1: Cell membrane; Single-pass type I membrane protein
    TNR6_HUMAN, P25445: Isoform 2: Secreted
    TNR6_HUMAN, P25445: Isoform 3: Secreted
    TNR6_HUMAN, P25445: Isoform 4: Secreted
    TNR6_HUMAN, P25445: Isoform 5: Secreted
    TNR6_HUMAN, P25445: Isoform 6: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    extracellular5
    plasma membrane5
    nucleus4
    cytoskeleton1
    endoplasmic reticulum1
    lysosome1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol NAS7533181
    GO:0005886plasma membrane TAS--

    Find genes that share ontologies with FAS           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FAS About   (see all 36)  
    See pathways by source

    SuperPathContained pathways About
    1Allograft rejection
    Allograft rejection0.86
    Graft-versus-host disease0.65
    Allograft Rejection0.86
    Autoimmune thyroid disease0.61
    Type I diabetes mellitus0.69
    2TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    3Apoptosis and survival Caspase cascade
    Apoptosis and survival Caspase cascade0.44
    FAS pathway and Stress induction of HSP regulation0.44
    Apoptosis and survival FAS signaling cascades0.44
    4MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    5Alzheimer's disease
    Alzheimers Disease0.44
    Alzheimer's disease0.44


    Find genes that share SuperPaths with FAS           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 R&D Systems Pathways for FAS
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
    Apoptosis Signaling Pathways
    IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FAS (see all 21)
        Caspase Cascade
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions

    3 Cell Signaling Technology (CST) Pathways for FAS
        Apoptosis and Autophagy
    Lymphocyte Signaling
    NF-kappaB Signaling

    Selected GeneGo (Thomson Reuters) Pathways for FAS (see all 9)
        Immune response Bacterial infections in normal airways
    Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades
    Bacterial infections in CF airways
    Apoptosis and survival Apoptotic TNF-family pathways

    Selected BioSystems Pathways for FAS (see all 14)
        MAPK signaling pathway
    Apoptosis
    DNA damage response
    Apoptosis Modulation and Signaling
    Adipogenesis

    4 Sino Biological Pathways for FAS
        TNF Signaling
    p53 Pathway
    Death Receptor Signaling
    NF-kB (NFkB) Pathway

    1 Reactome Pathway for FAS
        FasL/ CD95L signaling


    Selected Kegg Pathways  (Kegg details for FAS) (see all 20):
        MAPK signaling pathway
    Cytokine-cytokine receptor interaction
    p53 signaling pathway
    Apoptosis
    Natural killer cell mediated cytotoxicity

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FAS (see all 24): 
              Cell Surface Markers in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Autophagy in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FAS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FAS (P254451, 2, 3 ENSP000003479794) via UniProtKB, MINT, STRING, and/or I2D (see all 105)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN13Q129231, 2, 3, ENSP000003947944EBI-494743,EBI-355227 MINT-8310831 MINT-8310795 MINT-8310858 MINT-8310845 MINT-8283218 MINT-8310809 MINT-8310820 MINT-8283266 I2D: score=5 STRING: ENSP00000394794
    CASP8Q147901, 2, 3, ENSP000003512734EBI-494743,EBI-78060 MINT-1956415 MINT-4055373 MINT-4055317 I2D: score=9 STRING: ENSP00000351273
    ENSG00000227046Q9UER71, 3, ENSP000004107724EBI-494743,EBI-77321 I2D: score=4 STRING: ENSP00000410772
    ENSG00000206206Q9UER71, 3EBI-494743,EBI-77321 I2D: score=4 
    ENSG00000206279Q9UER71, 3EBI-494743,EBI-77321 I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 38):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002377immunoglobulin production IEA--
    GO:0003014renal system process IEA--
    GO:0006461protein complex assembly TAS10875918
    GO:0006915apoptotic process TAS--
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process TAS--

    Find genes that share ontologies with FAS           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAS (TNR6)

    1 IUPHAR Ligand for FAS (Fas)    About this table
    LigandTypeActionAffinityPubmed IDs
    Fas ligand
    NoneNone--

    Selected Novoseek inferred chemical compound relationships for FAS gene (see all 143)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cerulenin 68.3 33 8631008 (4), 15806173 (2), 14767544 (2), 18410446 (2) (see all 19)
    dutp 67.6 15 9212738 (1), 10383736 (1), 12210368 (1), 12957613 (1) (see all 13)
    concanamycin a 63.9 1 11096347 (1)
    safrole oxide 62.5 7 16225864 (2), 16702019 (2), 16326105 (1), 16473419 (1)
    ceramide 62.4 87 10745271 (3), 11973615 (3), 18613813 (2), 11502750 (2) (see all 51)
    fatty acid 56.9 276 8631008 (8), 18056164 (6), 14767544 (5), 15607568 (5) (see all 99)
    cycloheximide 55.3 49 9832422 (2), 12861043 (2), 10568818 (2), 11779361 (2) (see all 33)
    7-aminoactinomycin d 50.2 4 11030869 (1), 11380462 (1), 18419713 (1)
    annexin-v 49.4 1 12480581 (1)
    c2ceramide 48.7 15 11536010 (3), 10830777 (2), 17440345 (1), 10886239 (1) (see all 7)



    Find genes that share compounds with FAS           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAS gene (8 alternative transcripts): 
    NM_000043.4  NM_152871.2  NM_152872.2  NM_152873.1  NM_152874.1  NM_152875.1  NM_152876.1  NM_152877.1  

    Unigene Cluster for FAS:

    Fas (TNF receptor superfamily, member 6)
    Hs.244139  [show with all ESTs]
    Unigene Representative Sequence: AB209361
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355740(uc010qna.2 uc001kfr.3 uc001kft.3 uc010qnb.2 uc001kfs.3 uc010qnc.2 uc010qnd.2 uc010qne.2 uc001kfw.3 uc009xtp.3)
    ENST00000352159 ENST00000484444 ENST00000357339 ENST00000488877 ENST00000494410
    ENST00000479522 ENST00000492756 ENST00000355279 ENST00000460510 ENST00000477270
    ENST00000313771 ENST00000466081 ENST00000371857 ENST00000494799 ENST00000487314

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FAS using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAS (see all 17):
    hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-374c hsa-let-7g hsa-let-7a hsa-miR-23a hsa-miR-98
    SwitchGear 3'UTR luciferase reporter plasmidFAS 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FAS
    Predesigned siRNA for gene silencing in human, mouse, rat FAS
    Clone
    Products:
         
    OriGene clones in human, mouse for FAS (see all 22)
    OriGene ORF clones in mouse, rat for FAS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): FAS (NM_000043)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAS
    Primer
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    Additional mRNA sequence: 

    AB209361.1 AK290978.1 AK311164.1 AK311424.1 AK311499.1 AY495076.1 BC012479.1 CR450307.1 
    EU481974.1 FJ200481.1 FJ373045.1 FJ373046.1 FM246457.1 FM246458.1 FM246459.1 M67454.1 
    NR_028033.2 NR_028034.2 NR_028035.2 NR_028036.2 NR_028371.1 X63717.1 X83490.1 X83491.1 
    X83492.1 X83493.1 X89101.1 Z47993.1 Z47994.1 Z47995.1 Z66556.1 Z70519.1 
    Z70520.1 

    20 DOTS entries:

    DT.455842  DT.100031255  DT.100031258  DT.100728449  DT.86821059  DT.95269153  DT.100689381  DT.100689391 
    DT.113385  DT.113386  DT.100031256  DT.121212588  DT.100779824  DT.95269151  DT.121212505  DT.95308040 
    DT.121212594  DT.121212597  DT.121212598  DT.95229610 

    Selected AceView cDNA sequences (see all 109):

    BE501338 X83493 AA521286 NM_152873 CR625848 NM_152874 NM_152875 NM_152877 
    CB135078 AA550824 BM790665 NM_152872 X89101 BC012479 X63717 CB266238 
    X83492 W51756 BE856244 M67454 BM976104 NM_152876 NM_000043 BQ051037 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FAS (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b
    SP1:                          -     -     -     -     -                                   -                     
    SP2:                          -     -     -     -     -                                   -     -               
    SP3:                                                                    -     -           -                     
    SP4:                          -     -     -     -     -                 -     -           -                     
    SP5:                          -     -     -     -     -           -     -     -           -                     


    ECgene alternative splicing isoforms for FAS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    FAS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAACCTGC
    FAS Expression
    About this image


    FAS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Line H9 (Naive)
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone marrow-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
     
     Tooth (Integumentary System)
             Primary Enamel Knot Cells Enamel Knot
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    FAS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.244139

    UniProtKB/Swiss-Prot: TNR6_HUMAN, P25445
    Tissue specificity: Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear
    cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FAS (see all 24): 
              Cell Surface Markers in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Autophagy in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for FAS gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fas1 , 5 Fas (TNF receptor superfamily member 6)1, 5 64.72(n)1
    49.69(a)1
      19 (29.48 cM)5
    141021  NM_007987.21  NP_032013.21 
     342906595 
    chicken
    (Gallus gallus)
    Aves FAS1 Fas (TNF receptor superfamily, member 6) 50.06(n)
    37.21(a)
      395274  NM_001199487.1  NP_001186416.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAS6
    Fas cell surface death receptor
    39(a)
    1 ↔ 1
    GL343246.1(130333-141781)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fas1 Fas cell surface death receptor 46.58(n)
    35.69(a)
      100124750  NM_001102729.1  NP_001096199.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fas1 Fas (TNF receptor superfamily, member 6) 46.58(n)
    30.13(a)
      768248  XM_685355.4  XP_690447.4 


    ENSEMBL Gene Tree for FAS (if available)
    TreeFam Gene Tree for FAS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAS gene
    2 SIMAP similar genes for FAS using alignment to 8 protein entries:     TNR6_HUMAN (see all proteins):
    TNFRSF6    CD95

    Find genes that share paralogs with FAS           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAS (see all 525)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs289294981,2,,4
    CAutoimmune lymphoproliferative syndrome 1A (ALPS1A)4 pathogenic191145671(+) AATAGA/TTGAGA 9 D V nc-transcript-variantmis1 ut310--------
    VAR_0134304
    Autoimmune lymphoproliferative syndrome 1A (ALPS1A)4--see VAR_0134302 D Y mis40--------
    VAR_0651324
    Autoimmune lymphoproliferative syndrome 1A (ALPS1A)4--see VAR_0651322 T K mis40--------
    VAR_0183234
    Squamous cell carcinoma4--see VAR_0183232 N D mis40--------
    VAR_0651294
    Autoimmune lymphoproliferative syndrome 1A (ALPS1A)4--see VAR_0651292 G D mis40--------
    VAR_0134234
    Autoimmune lymphoproliferative syndrome 1A (ALPS1A)4--see VAR_0134232 Y C mis40--------
    VAR_0651314
    Autoimmune lymphoproliferative syndrome 1A (ALPS1A)4--see VAR_0651312 I R mis40--------
    VAR_0134364
    Non-Hodgkin lymphoma4--see VAR_0134362 L F mis40--------
    VAR_0134374
    Non-Hodgkin lymphoma4--see VAR_0134372 K N mis40--------
    VAR_0134354
    Autoimmune lymphoproliferative syndrome 1A (ALPS1A)4--see VAR_0134352 E K mis40--------

    HapMap Linkage Disequilibrium report for FAS (90750288 - 90775542 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FAS:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831943CNV Gain17160897

    Human Gene Mutation Database (HGMD): FAS
    Locus Specific Mutation Databases (LSDB): FAS

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAS
    DNA2.0 Custom Variant and Variant Library Synthesis for FAS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 134637   
    OMIM disorders: 601859  
    UniProtKB/Swiss-Prot: TNR6_HUMAN, P25445
  • Autoimmune lymphoproliferative syndrome 1A (ALPS1A) [MIM:601859]: A disorder of apoptosis that manifests
    in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by
    non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and
    neutropenia. Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for FAS (see all 33):    
    About MalaCards
    burn scar    squamous cell carcinoma, burn scar-related, somatic    autoimmune lymphoproliferative syndrome, type ia    autoimmune lymphoproliferative syndrome
    fas-related autoimmune lymphoproliferative syndrome    persistent polyclonal b-cell lymphocytosis    acid sphingomyelinase deficiency    htlv-1 associated myelopathy
    toxic epidermal necrolysis    silicosis    idiopathic anterior uveitis    lymphoproliferative syndrome 1
    autoimmune lymphoproliferative syndrome, type ib    stevens-johnson syndrome    acute myocarditis    anterior uveitis
    oligoarticular juvenile arthritis    type ii mixed cryoglobulinemia    polyarticular onset juvenile idiopathic arthritis    vogt-koyanagi-harada disease

    1 disease from the University of Copenhagen DISEASES database for FAS:
    Autoimmune lymphoproliferative syndrome

    Find genes that share disorders with FAS           About GenesLikeMe

    Selected Novoseek inferred disease relationships for FAS gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune lymphoproliferative syndrome 90.8 102 15640690 (3), 10340403 (2), 17605793 (2), 9028321 (2) (see all 65)
    necrosis 80.5 899 15940614 (6), 10887332 (5), 11782299 (3), 15195900 (3) (see all 99)
    tumors 76.7 1787 12222835 (8), 11150435 (7), 11692157 (6), 12480581 (6) (see all 99)
    dianzani autoimmune lymphoproliferative disease 69 1 16537120 (1)
    autoimmune diseases 63.4 83 9826578 (2), 10548879 (2), 9862736 (2), 11791468 (2) (see all 59)
    autoimmunity 60.9 63 11318598 (2), 12930371 (2), 11256883 (2), 8929361 (2) (see all 41)
    tumor escape 58.7 6 10383736 (1), 15968727 (1), 10415870 (1), 11523216 (1) (see all 5)
    cancer 58.5 343 15577743 (6), 20505730 (6), 12498219 (3), 11323104 (3) (see all 99)
    toxic epidermal necrolysis 53.9 13 10951228 (2), 11103436 (2), 12655300 (1), 17460400 (1) (see all 11)
    hashimotos thyroiditis 53.8 43 14585083 (3), 12480911 (3), 10917176 (3), 9396343 (2) (see all 25)

    GeneTests: FAS
    GeneReviews: FAS
    Genetic Association Database (GAD): FAS
    Human Genome Epidemiology (HuGE) Navigator: FAS (234 documents)

    Export disorders for FAS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAS gene, integrated from 10 sources (see all 3694):
    (articles sorted by number of sources associating them with FAS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis. (PubMed id 11418480)1, 2, 4, 9 Straus S.E.... Lenardo M.J. (Blood 2001)
    2. Somatic Fas mutations in non-Hodgkin's lymphoma: association with extranodal disease and autoimmunity. (PubMed id 9787134)1, 2, 4, 9 Groenbaek K.... Guldberg P. (Blood 1998)
    3. Autoimmune lymphoproliferative syndrome with defective Fas: genotype influences penetrance. (PubMed id 10090885)1, 2, 9 Jackson C.E.... Puck J.M. (Am. J. Hum. Genet. 1999)
    4. Study of Fas (CD95) and FasL (CD178) polymorphisms in liver transplant recipients. (PubMed id 16441482)1, 4, 9 MarA-n L.A....Alvarez-LA^pez M.R. (Tissue Antigens 2006)
    5. FAS and FAS ligand polymorphisms in the promoter regions and risk of gastric cancer in Southern China. (PubMed id 19565204)1, 4, 9 Wang M....Zhang Z. (Biochem. Genet. 2009)
    6. Genetic polymorphisms in the apoptosis-associated genes FAS and FASL and breast cancer risk. (PubMed id 17962219)1, 4, 9 Crew K.D....Santella R.M. (Carcinogenesis 2007)
    7. Polymorphisms in the FAS and FASL genes and risk of lung cancer in a Korean population. (PubMed id 17014925)1, 4, 9 Park S.H....Park J.Y. (Lung Cancer 2006)
    8. Functional polymorphisms in cell death pathway genes FAS and FASL contribute to risk of lung cancer. (PubMed id 15937082)1, 4, 9 Zhang X....Lin D. (J. Med. Genet. 2005)
    9. Genetic polymorphisms of Fas (CD95) and Fas ligand (CD178) influence the rise in CD4+ T cell count after antiretroviral therapy in drug-naA^ve HIV-positive patients. (PubMed id 16158329)1, 4, 9 Nasi M....Cossarizza A. (Immunogenetics 2005)
    10. Somatic mutations of Fas (Apo-1/CD95) gene in cutaneous squamous cell carcinoma arising from a burn scar. (PubMed id 10620127)1, 2, 9 Lee S.H.... Yoo N.J. (J. Invest. Dermatol. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 355 HGNC: 11920 AceView: TNFRSF6 Ensembl:ENSG00000026103 euGenes: HUgn355
    ECgene: FAS Kegg: 355 H-InvDB: FAS

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FAS Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FAS Genetics and Cytogenetics in Oncology and Haematology
    Autoimmune Lymphoproliferative Syndrome Database (ALPSbase)http://research.nhgri.nih.gov/ALPS/alpsIa_mut.shtml
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=FAS[genesymbol]
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tnfrsf6/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAS gene:
    Search GeneIP for patents involving FAS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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