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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAS Gene

protein-coding   GIFtS: 73
GCID: GC10P090741

Fas Cell Surface Death Receptor

(Previous names: tumor necrosis factor receptor superfamily, member 6, Fas...)
(Previous symbols: FAS1, APT1, TNFRSF6)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4

Aliases
Fas Cell Surface Death Receptor1 2     CD952 5
APT11 2 3 5     APO-12
TNFRSF61 2 3 5     FASTM2
FAS11 2 3     APO-1 Cell Surface Antigen2
Fas (TNF Receptor Superfamily, Member 6)1 2     Apoptosis Antigen 12
Tumor Necrosis Factor Receptor Superfamily, Member 61 2     Delta Fas/APO-1/CD952
TNF Receptor Superfamily Member 61 2     FAS 827dupA2
Apoptosis-Mediating Surface Antigen FAS2 3     Fas AMA2
CD95 Antigen2 3     Tumor Necrosis Factor Receptor Superfamily Member 62
FASLG Receptor2 3     Apo-1 Antigen3
ALPS1A2 5     

External Ids:    HGNC: 119201   Entrez Gene: 3552   Ensembl: ENSG000000261037   OMIM: 1346375   UniProtKB: P254453   
ORGUL members:    fRNAdb10:FR070864      
H-InvDB12:HIT000216821    
NCBI13:S78781    
NONCODE14:n408105 n408104      
RNAdb15:HIV2479    

Export aliases for FAS gene to outside databases

Previous GC identifer: GC10P084384


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FAS Gene:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death
domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and
has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The
interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that
includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of
the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been
also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the
proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants
have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking
the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. (provided by
RefSeq, Mar 2011)

GeneCards Summary for FAS Gene: 
FAS (Fas cell surface death receptor) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with FAS include autoimmune lymphoproliferative syndrome, type ia, and fas-related autoimmune lymphoproliferative syndrome, and among its related super-pathways are TNF Signaling and Parkinson's disease. GO annotations related to this gene include receptor activity and identical protein binding.

UniProtKB/Swiss-Prot: TNR6_HUMAN, P25445
Function: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The
resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the
subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated
apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature
T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro)

Gene Wiki entry for FAS (Fas receptor) Gene

fRNAdb sequence ontology for FAS:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAS gene promoter:
         STAT1   AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FAS promoter sequence
   Search SABiosciences Chromatin IP Primers for FAS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.1   Ensembl cytogenetic band:  10q23.31   HGNC cytogenetic band: 10q24.1

FAS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAS gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P090741:  view genomic region     (about GC identifiers)

Start:
90,750,288 bp from pter      End:
90,775,542 bp from pter
Size:
25,255 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for FAS

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TNR6_HUMAN, P25445 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor superfamily member 6 precursor  
Size: 335 amino acids; 37732 Da
Subunit: Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD (By similarity). Binds
RIPK1 and FAIM2. Interacts with BRE and FEM1B. Interacts with FADD
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Secreted
Subcellular location: Isoform 3: Secreted
Subcellular location: Isoform 4: Secreted
Subcellular location: Isoform 5: Secreted
Subcellular location: Isoform 6: Secreted
6 PDB 3D structures from and Proteopedia for FAS:
1BZI (3D)        1DDF (3D)        3EWT (3D)        3EZQ (3D)        3THM (3D)        3TJE (3D)    
Secondary accessions: A9UJX4 B6VNV4 Q14292 Q14293 Q14294 Q14295 Q16652 Q5T9P1 Q5T9P2 Q5T9P3
Q6SSE9
Alternative splicing: 7 isoforms:  P25445-1   P25445-2   P25445-3   P25445-4   P25445-5   P25445-6   P25445-7   (Dominant negative isoform, resistant to Fas-mediated apoptosis)

Explore the universe of human proteins at neXtProt for FAS: NX_P25445

Explore proteomics data for FAS at MOPED 

Post-translational modifications:

  • UniProtKB: N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P25445

  • FAS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAS Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_000034.1  NP_690610.1  NP_690611.1  

    ENSEMBL proteins: 
     ENSP00000347979   ENSP00000345601   ENSP00000420975   ENSP00000349896   ENSP00000425159  
     ENSP00000423755   ENSP00000424113   ENSP00000422453   ENSP00000347426  
    Reactome Protein details: P25445
    Human Recombinant Protein Products for FAS: 
    EMD Millipore Purified and/or Recombinant FAS Protein
    R&D Systems Recombinant & Natural Proteins for FAS (Fas/TNFRSF6/CD95)
    Enzo Life Sciences proteins for FAS
    OriGene Purified Protein for FAS
    OriGene Protein Over-expression Lysate for FAS
    OriGene MassSpec for FAS 
    OriGene Custom Protein Services for FAS
    GenScript Custom Purified and Recombinant Proteins Services for FAS
    Novus Biologicals FAS Proteins
    Novus Biologicals FAS Lysates
    Sino Biological Recombinant Protein for FAS
    Sino Biological Cell Lysate for FAS 
    ProSpec Recombinant Protein for FAS
    Cloud-Clone Corp. Proteins for FAS 

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol NAS7533181
    GO:0005886plasma membrane TAS--

    FAS for ontologies           About GeneDecksing



    FAS Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of FAS
    R&D Systems Antibodies for FAS (Fas/TNFRSF6/CD95)
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    Novus Biologicals FAS Antibodies
    Abcam antibodies for FAS
    Cloud-Clone Corp. Antibodies for FAS 
    ThermoFisher Antibody for FAS
    LSBio Antibodies in human, mouse, rat for FAS 

    Assay Products for FAS: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for FAS (Fas/TNFRSF6/CD95)         (see all)
    GenScript Custom Assay Services for FAS
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FAS 
    Cloud-Clone Corp. CLIAs for FAS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    TNFRSF: Tumor necrosis factor receptor superfamily

    IUPHAR Guide to PHARMACOLOGY protein family classification: Fas 
    Tumour necrosis factor (TNF) receptor family

    4 InterPro protein domains:
     IPR011029 DEATH-like_dom
     IPR001368 TNFR/NGFR_Cys_rich_reg
     IPR008063 Fas_rcpt
     IPR000488 Death_domain

    Graphical View of Domain Structure for InterPro Entry P25445

    ProtoNet protein and cluster: P25445

    3 Blocks protein domains:
    IPB000488 Death domain
    IPB001368 TNFR/CD27/30/40/95 cysteine-rich region
    IPB008063 FAS/CD95 receptor family signature


    UniProtKB/Swiss-Prot: TNR6_HUMAN, P25445
    Domain: Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins
    Similarity: Contains 1 death domain
    Similarity: Contains 3 TNFR-Cys repeats


    FAS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNR6_HUMAN, P25445
    Function: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The
    resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the
    subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated
    apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature
    T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro)

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity TAS10875918
    GO:0004872receptor activity NAS7533181
    GO:0004888transmembrane signaling receptor activity IEA--
    GO:0005515protein binding IPI10918185
    GO:0019900kinase binding IPI7538908
         
    FAS for ontologies           About GeneDecksing


    Phenotypes:
         15/23 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Fas) (see all 23):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  liver/biliary system  mortality/aging 

    FAS for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FAS: Fastm1Dlo Fastm1.1Cgn

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FAS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FAS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAS 

    miRNA
    Products:
        
    miRTarBase miRNAs that target FAS:
    hsa-mir-146a (MIRT005581)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FAS
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate FAS (see all 17):
    hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-374c hsa-let-7g hsa-let-7a hsa-miR-23a hsa-miR-98
    SwitchGear 3'UTR luciferase reporter plasmidFAS 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FAS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAS

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of FAS

    Clone
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    OriGene clones in human, mouse for FAS (see all 20)
    OriGene ORF clones in mouse, rat for FAS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): FAS (NM_000043)
    Sino Biological Human cDNA Clone for FAS
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAS
    Sirion Biotech Customized lentivirus for stable overexpression of FAS 
                         Customized lentivirus expression plasmids for stable overexpression of FAS 

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    GenScript Custom overexpressing Cell Line Services for FAS
    Search LifeMap BioReagents cell lines for FAS
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FAS About   (see all 36)                                                                                              See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    2Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Alzheimer's disease0.46
    Non-alcoholic fatty liver disease (NAFLD)0.41
    Alzheimers Disease0.44
    3Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades0.44
    FAS pathway and Stress induction of HSP regulation0.44
    Apoptosis and survival Caspase cascade0.44
    4MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    5p53 signaling pathway
    DNA damage response0.41
    p53 signaling pathway0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/7 EMD Millipore Pathways for FAS (see all 7)
        Development HGF signaling pathway
    Apoptosis and survival Caspase cascade
    Proteolysis Putative SUMO-1 pathway
    Apoptosis and survival FAS signaling cascades
    Signal transduction JNK pathway

    4 R&D Systems Pathways for FAS
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
    Apoptosis Signaling Pathways
    IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types


    3 Cell Signaling Technology (CST) Pathways for FAS
        Apoptosis and Autophagy
    Lymphocyte Signaling
    NF-kappaB Signaling

    5/9 GeneGo (Thomson Reuters) Pathways for FAS (see all 9)
        Immune response Bacterial infections in normal airways
    Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades
    Bacterial infections in CF airways
    Apoptosis and survival Apoptotic TNF-family pathways

    5/13 BioSystems Pathways for FAS (see all 13)
        MAPK signaling pathway
    DNA damage response
    Apoptosis
    Apoptosis Modulation and Signaling
    Adipogenesis

    4 Sino Biological Pathways for FAS 
        TNF Signaling
    p53 Pathway
    Death Receptor Signaling
    NF-kB (NFkB) Pathway

    5/7        Reactome Pathways for FAS (see all 7)
        Death Receptor Signalling
    FasL/ CD95L signaling
    Extrinsic Pathway for Apoptosis
    Caspase-8 activation
    Dimerization of procaspase-8


    5/20         Kegg Pathways  (Kegg details for FAS) (see all 20):
        MAPK signaling pathway
    Cytokine-cytokine receptor interaction
    p53 signaling pathway
    Apoptosis
    Natural killer cell mediated cytotoxicity


    FAS for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FAS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/105 Interacting proteins for FAS (P254451, 2, 3 ENSP000003479794) via UniProtKB, MINT, STRING, and/or I2D (see all 105)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN13Q129232, 3, ENSP000003947944MINT-8310831 MINT-8310795 MINT-8310858 MINT-8310845 MINT-8283218 MINT-8310809 MINT-8310820 MINT-8283266 I2D: score=5 STRING: ENSP00000394794
    CASP8Q147901, 2, 3, ENSP000003512734EBI-494743,EBI-78060 MINT-1956415 MINT-4055373 MINT-4055317 I2D: score=9 STRING: ENSP00000351273
    ENSG00000227046Q9UER71, 3, ENSP000004107724EBI-494743,EBI-77321 I2D: score=4 STRING: ENSP00000410772
    ENSG00000231617Q9UER71, 3, ENSP000004046234EBI-494743,EBI-77321 I2D: score=4 STRING: ENSP00000404623
    ENSG00000206206Q9UER71, 3EBI-494743,EBI-77321 I2D: score=4 
    About this table

    Gene Ontology (GO): 5/33 biological process terms (GO ID links to tree view) (see all 33):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002377immunoglobulin production IEA--
    GO:0003014renal system process IEA--
    GO:0006461protein complex assembly TAS10875918
    GO:0006915apoptotic process TAS--
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process TAS--

    FAS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FAS for compounds           About GeneDecksing

    EMD Millipore small molecules for FAS:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAS (TNR6)

    1 IUPHAR Ligand for FAS (Fas)    About this table 
    LigandTypeActionAffinityPubmed IDs
    Fas ligand
    NoneNone--

    10/143 Novoseek inferred chemical compound relationships for FAS gene (see all 143)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cerulenin 68.3 33 8631008 (4), 15806173 (2), 14767544 (2), 18410446 (2) (see all 19)
    dutp 67.6 15 9212738 (1), 10383736 (1), 12210368 (1), 12957613 (1) (see all 13)
    concanamycin a 63.9 1 11096347 (1)
    safrole oxide 62.5 7 16225864 (2), 16702019 (2), 16326105 (1), 16473419 (1)
    ceramide 62.4 87 10745271 (3), 11973615 (3), 18613813 (2), 11502750 (2) (see all 51)
    fatty acid 56.9 276 8631008 (8), 18056164 (6), 14767544 (5), 15607568 (5) (see all 99)
    cycloheximide 55.3 49 9832422 (2), 12861043 (2), 10568818 (2), 11779361 (2) (see all 33)
    7-aminoactinomycin d 50.2 4 11030869 (1), 11380462 (1), 18419713 (1)
    annexin-v 49.4 1 12480581 (1)
    c2ceramide 48.7 15 11536010 (3), 10830777 (2), 17440345 (1), 10886239 (1) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about FAS / TNR6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAS gene (8 alternative transcripts): 
    NM_000043.4  NM_152871.2  NM_152872.2  NM_152873.1  NM_152874.1  NM_152875.1  NM_152876.1  NM_152877.1  

    Unigene Cluster for FAS:

    Fas (TNF receptor superfamily, member 6)
    Hs.244139  [show with all ESTs]
    Unigene Representative Sequence: AB209361
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355740(uc010qna.2 uc001kfr.3 uc001kft.3 uc010qnb.2 uc001kfs.3 uc010qnc.2 uc010qnd.2 uc010qne.2 uc001kfw.3 uc009xtp.3)
    ENST00000352159 ENST00000484444 ENST00000357339 ENST00000488877 ENST00000494410
    ENST00000479522 ENST00000492756 ENST00000355279 ENST00000460510 ENST00000477270
    ENST00000313771 ENST00000466081 ENST00000371857 ENST00000494799 ENST00000487314

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate FAS (see all 17):
    hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-374c hsa-let-7g hsa-let-7a hsa-miR-23a hsa-miR-98
    SwitchGear 3'UTR luciferase reporter plasmidFAS 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    OriGene ORF clones in mouse, rat for FAS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): FAS (NM_000043)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAS
    Sirion Biotech Customized lentivirus for stable overexpression of FAS 
                         Customized lentivirus expression plasmids for stable overexpression of FAS 
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    Additional mRNA sequence: 

    AB209361.1 AK290978.1 AK311164.1 AK311424.1 AK311499.1 AY495076.1 BC012479.1 CR450307.1 
    EU481974.1 FJ200481.1 FJ373045.1 FJ373046.1 FM246457.1 FM246458.1 FM246459.1 M67454.1 
    NR_028033.2 NR_028034.2 NR_028035.2 NR_028036.2 NR_028371.1 X63717.1 X83490.1 X83491.1 
    X83492.1 X83493.1 X89101.1 Z47993.1 Z47994.1 Z47995.1 Z66556.1 Z70519.1 
    Z70520.1 

    20 DOTS entries:

    DT.455842  DT.100031255  DT.100031258  DT.100728449  DT.86821059  DT.95269153  DT.100689381  DT.100689391 
    DT.113385  DT.113386  DT.100031256  DT.121212588  DT.100779824  DT.95269151  DT.121212505  DT.95308040 
    DT.121212594  DT.121212597  DT.121212598  DT.95229610 

    24/109 AceView cDNA sequences (see all 109):

    BX113824 AA521286 NM_152872 BQ051037 BQ000413 BC012479 AL542093 CR625848 
    X83493 BM790665 CB266238 X63717 W51756 X83492 NM_152876 NM_000043 
    CB135078 NM_152871 NM_152877 BM976104 M67454 N45281 AA550824 AA293571 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for FAS (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b
    SP1:                          -     -     -     -     -                                   -                     
    SP2:                          -     -     -     -     -                                   -     -               
    SP3:                                                                    -     -           -                     
    SP4:                          -     -     -     -     -                 -     -           -                     
    SP5:                          -     -     -     -     -           -     -     -           -                     


    ECgene alternative splicing isoforms for FAS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAS expression in normal human tissues (normalized intensities)      FAS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAACCTGC
    FAS Expression
    About this image


    FAS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Bone (Muscoskeletal System)
             Bone marrow-derived mesenchymal stem cells
     
     Tooth (Integumentary System)
             Primary Enamel Knot Cells Enamel Knot
     
     Blood (Hematopoietic System)
             leukocytes   
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells

    See FAS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAS

    SOURCE GeneReport for Unigene cluster: Hs.244139

    UniProtKB/Swiss-Prot: TNR6_HUMAN, P25445
    Tissue specificity: Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear
    cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6

        SABiosciences Expression via Pathway-Focused PCR Arrays including FAS (see all 24): 
              Cell Surface Markers in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Autophagy in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FAS gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fas1 , 5 Fas (TNF receptor superfamily member 6)1, 5 65.64(n)1
    50.61(a)1
      19 (29.48 cM)5
    141021  NM_007987.21  NP_032013.21 
     342906595 
    chicken
    (Gallus gallus)
    Aves FAS1 Fas (TNF receptor superfamily, member 6) 50.5(n)
    37.21(a)
      395274  NM_001199487.1  NP_001186416.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAS6
    Uncharacterized protein
    33(a)
    1 ↔ 1
    GL343246.1(130333-141781)
    zebrafish
    (Danio rerio)
    Actinopterygii fas1 Fas (TNF receptor superfamily, member 6) 47.23(n)
    32.34(a)
      768248  XM_685355.3  XP_690447.3 


    ENSEMBL Gene Tree for FAS (if available)
    TreeFam Gene Tree for FAS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAS gene
    2 SIMAP similar genes for FAS using alignment to 6 protein entries:     TNR6_HUMAN (see all proteins):
    TNFRSF6    CD95

    FAS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/525 SNPs in FAS are shown (see all 525)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0134304
    Autoimmune lymphoproliferative syndrome 1A (ALPS1A)4--see VAR_0134302 D Y mis40--------
    VAR_0651324
    Autoimmune lymphoproliferative syndrome 1A (ALPS1A)4--see VAR_0651322 T K mis40--------
    VAR_0183234
    Squamous cell carcinoma4--see VAR_0183232 N D mis40--------
    VAR_0651294
    Autoimmune lymphoproliferative syndrome 1A (ALPS1A)4--see VAR_0651292 G D mis40--------
    VAR_0134234
    Autoimmune lymphoproliferative syndrome 1A (ALPS1A)4--see VAR_0134232 Y C mis40--------
    VAR_0651314
    Autoimmune lymphoproliferative syndrome 1A (ALPS1A)4--see VAR_0651312 I R mis40--------
    VAR_0134364
    Non-Hodgkin lymphoma4--see VAR_0134362 L F mis40--------
    VAR_0134374
    Non-Hodgkin lymphoma4--see VAR_0134372 K N mis40--------
    VAR_0134354
    Autoimmune lymphoproliferative syndrome 1A (ALPS1A)4--see VAR_0134352 E K mis40--------
    VAR_0651304
    Autoimmune lymphoproliferative syndrome 1A (ALPS1A)4--see VAR_0651302 G S mis40--------

    HapMap Linkage Disequilibrium report for FAS (90750288 - 90775542 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FAS:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831943CNV Gain17160897


    Human Gene Mutation Database (HGMD): FAS

    Locus Specific Mutation Databases (LSDB): FAS
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for FAS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 134637OMIM information: 603188 607499    
    OMIM disorders: 601859  
    UniProtKB/Swiss-Prot: TNR6_HUMAN, P25445
  • Autoimmune lymphoproliferative syndrome 1A (ALPS1A) [MIM:601859]: A disorder of apoptosis that manifests
    in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by
    non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and
    neutropenia. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20/322 diseases for FAS (see all 322):    About MalaCards
    autoimmune lymphoproliferative syndrome, type ia    fas-related autoimmune lymphoproliferative syndrome    autoimmune lymphoproliferative syndrome    toxic epidermal necrolysis
    persistent polyclonal b-cell lymphocytosis    silicosis    caspase-8 deficiency    idiopathic anterior uveitis
    stevens-johnson syndrome    ovarian serous cystadenocarcinoma    vogt-koyanagi-harada disease    acute t cell leukemia
    serous cystadenocarcinoma    thyroid lymphoma    type ii mixed cryoglobulinemia    acid sphingomyelinase deficiency
    lumbar disc degeneration    t-lymphocytopenia    alexia    lymphomatoid papulosis

    1 disease from the University of Copenhagen DISEASES database for FAS:
    Autoimmune lymphoproliferative syndrome

    FAS for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/93 Novoseek inferred disease relationships for FAS gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune lymphoproliferative syndrome 90.8 102 15640690 (3), 10340403 (2), 17605793 (2), 9028321 (2) (see all 65)
    necrosis 80.5 899 15940614 (6), 10887332 (5), 11782299 (3), 15195900 (3) (see all 99)
    tumors 76.7 1787 12222835 (8), 11150435 (7), 11692157 (6), 12480581 (6) (see all 99)
    dianzani autoimmune lymphoproliferative disease 69 1 16537120 (1)
    autoimmune diseases 63.4 83 9826578 (2), 10548879 (2), 9862736 (2), 11791468 (2) (see all 59)
    autoimmunity 60.9 63 11318598 (2), 12930371 (2), 11256883 (2), 8929361 (2) (see all 41)
    tumor escape 58.7 6 10383736 (1), 15968727 (1), 10415870 (1), 11523216 (1) (see all 5)
    cancer 58.5 343 15577743 (6), 20505730 (6), 12498219 (3), 11323104 (3) (see all 99)
    toxic epidermal necrolysis 53.9 13 10951228 (2), 11103436 (2), 12655300 (1), 17460400 (1) (see all 11)
    hashimotos thyroiditis 53.8 43 14585083 (3), 12480911 (3), 10917176 (3), 9396343 (2) (see all 25)

    GeneTests: FAS
    GeneReviews: FAS
    Genetic Association Database (GAD): FAS
    Human Genome Epidemiology (HuGE) Navigator: FAS (234 documents)

    Export disorders for FAS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAS gene, integrated from 9 sources (see all 3672):
    (articles sorted by number of sources associating them with FAS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis. (PubMed id 11418480)1, 2, 4, 9 Straus S.E.... Lenardo M.J. (2001)
    2. Somatic Fas mutations in non-Hodgkin's lymphoma: association with extranodal disease and autoimmunity. (PubMed id 9787134)1, 2, 4, 9 Groenbaek K.... Guldberg P. (1998)
    3. Autoimmune lymphoproliferative syndrome with defective Fas: genotype influences penetrance. (PubMed id 10090885)1, 2, 9 Jackson C.E.... Puck J.M. (1999)
    4. Study of Fas (CD95) and FasL (CD178) polymorphisms in liver transplant recipients. (PubMed id 16441482)1, 4, 9 Marin L.A....Alvarez-Lopez M.R. (2006)
    5. FAS and FAS ligand polymorphisms in the promoter regi ons and risk of gastric cancer in Southern China. (PubMed id 19565204)1, 4, 9 Wang M....Zhang Z. (2009)
    6. Genetic polymorphisms in the apoptosis-associated genes FAS and FASL and breast cancer risk. (PubMed id 17962219)1, 4, 9 Crew K.D....Santella R.M. (2007)
    7. Polymorphisms in the FAS and FASL genes and risk of lung cancer in a Korean population. (PubMed id 17014925)1, 4, 9 Park S.H....Park J.Y. (2006)
    8. Functional polymorphisms in cell death pathway genes FAS and FASL contribute to risk of lung cancer. (PubMed id 15937082)1, 4, 9 Zhang X....Lin D. (2005)
    9. Genetic polymorphisms of Fas (CD95) and Fas ligand (CD178) influence the rise in CD4+ T cell count after antiretroviral therapy in drug-naive HIV-positive patients. (PubMed id 16158329)1, 4, 9 Nasi M....Cossarizza A. (2005)
    10. Somatic mutations of Fas (Apo-1/CD95) gene in cutaneous squamous cell carcinoma arising from a burn scar. (PubMed id 10620127)1, 2, 9 Lee S.H.... Yoo N.J. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 355 HGNC: 11920 AceView: TNFRSF6 Ensembl:ENSG00000026103 euGenes: HUgn355
    ECgene: FAS Kegg: 355 H-InvDB: FAS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAS Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FAS Genetics and Cytogenetics in Oncology and Haematology
    Autoimmune Lymphoproliferative Syndrome Database (ALPSbase)http://research.nhgri.nih.gov/ALPS/alpsIa_mut.shtml
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/FAS
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tnfrsf6/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAS gene:
    Search GeneIP for patents involving FAS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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