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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FAS Gene

protein-coding GIFtS: 71
GCID: GC10P090741

Fas (TNF receptor superfamily, member 6)

(Previous names: tumor necrosis factor receptor superfamily, member 6 )
(Previous symbols: FAS1, APT1, TNFRSF6)

Explore 344 diseases affiliated with
FAS via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4

Aliases
Fas (TNF Receptor Superfamily, Member 6)¹ ²		ALPS1A² ⁵
APT1¹ ² ³ ⁵		FASTM²
TNFRSF6¹ ² ³ ⁵		APO-1 Cell Surface Antigen²
FAS1¹ ² ³		Apoptosis Antigen 1²
CD95¹ ² ⁵		Delta Fas/APO-1/CD95²
APO-1¹ ²		FAS 827dupA²
Tumor Necrosis Factor Receptor Superfamily, Member 6¹ ²		Fas AMA²
Apoptosis-Mediating Surface Antigen FAS² ³		Tumor Necrosis Factor Receptor Superfamily Member 6²
CD95 Antigen² ³		Apo-1 Antigen³
FASLG Receptor² ³

External Ids:	HGNC: 11920¹	Entrez Gene: 355²	Ensembl: ENSG00000026103⁷	OMIM: 134637⁵	UniProtKB: P25445³

ORGUL members:	fRNAdb¹⁰:FR070864
	H-InvDB:HIT000216821
	NCBI:S78781
	NONCODE:n408104 n408105
	RNAdb:HIV2479

Export aliases for FAS gene to outside databases

Previous GC identifer: GC10P084384

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FAS:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It

has been shown to play a central role in the physiological regulation of programmed cell death, and has been

implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this

receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death

domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex

triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate

NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal

diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which

are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively

regulate the apoptosis mediated by the full length isoform. (provided by RefSeq, Mar 2011)

UniProtKB/Swiss-Prot: TNR6_HUMAN, P25445

Function: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The

resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the

subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may

have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.

The secreted isoforms 2 to 6 block apoptosis (in vitro)

Gene Wiki entry for FAS (Fas receptor)

fRNAdb sequence ontology for FAS:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FAS gene promoter:
STAT1 AP-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FAS promoter sequence

Search SABiosciences Chromatin IP Primers for FAS

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAS

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.1 Ensembl cytogenetic band: 10q23.31 HGNC cytogenetic band: 10q24.1

FAS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAS gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P090741: view genomic region (about GC identifiers)

Start:	90,750,288 bp from pter	End:	90,775,542 bp from pter
Size:	25,255 bases	Orientation:	plus strand

ORGUL member locations:
Legend (see complete legend)

n408104
n408105
FR0070864

lncRNA
Full Legend

90750287 90762915 90775542 chr10

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TNR6_HUMAN, P25445 (See protein sequence)

Recommended Name: Tumor necrosis factor receptor superfamily member 6 precursor

Size: 335 amino acids; 37732 Da

Subunit: Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD (By similarity). Binds RIPK1 and

FAIM2. Interacts with BRE and FEM1B. Interacts with FADD

Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein

Subcellular location: Isoform 2: Secreted

Subcellular location: Isoform 3: Secreted

Subcellular location: Isoform 4: Secreted

Subcellular location: Isoform 5: Secreted

Subcellular location: Isoform 6: Secreted

6 PDB 3D structures from and Proteopedia for FAS:

1BZI (3D)

1DDF (3D)

3EWT (3D)

3EZQ (3D)

3THM (3D)

3TJE (3D)

Secondary accessions: A9UJX4 B6VNV4 Q14292 Q14293 Q14294 Q14295 Q16652 Q5T9P1 Q5T9P2 Q5T9P3 Q6SSE9

Alternative splicing: 7 isoforms: P25445-1 P25445-2 P25445-3 P25445-4 P25445-5 P25445-6 P25445-7 (Dominant negative isoform, resistant to Fas-mediated apoptosis)

Explore the universe of human proteins at neXtProt for FAS: NX_P25445

Post-translational modifications:

N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P25445

FAS Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_000034.1 NP_690610.1 NP_690611.1

ENSEMBL proteins:

ENSP00000347979 ENSP00000345601 ENSP00000420975 ENSP00000349896 ENSP00000425159

ENSP00000423755 ENSP00000424113 ENSP00000422453 ENSP00000347426

Reactome Protein details: P25445
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant FAS Protein
	R&D Systems Recombinant & Natural Proteins for FAS (Fas/TNFRSF6/CD95)
	Enzo Life Sciences proteins for FAS
	OriGene Purified Protein: FAS OriGene Protein Over-expression Lysate (see all 2): FAS OriGene Custom Protein Services for FAS
	GenScript Custom Purified and Recombinant Proteins Services for FAS
	Novus Biologicals FAS Proteins Novus Biologicals FAS Lysates
	Sino Biological Recombinant Protein for FAS
	ProSpec Recombinant Protein for FAS
	Uscn Proteins for FAS

Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005625	soluble fraction	--	--
GO:0005634	nucleus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	NAS	7533181

FAS for ontologies About GeneDecksing

FAS Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of FAS
	R&D Systems Antibodies for FAS (Fas/TNFRSF6/CD95)
	Cell Signaling Technology (CST) Antibodies for FAS
	OriGene Antibodies (see all 3): FAS OriGene Custom Antibody Services for FAS
	GenScript Superior Antibodies for FAS
	Novus Biologicals FAS Antibodies
	Abcam antibodies for FAS
	Uscn Antibodies for FAS
	ThermoFisher Antibody for FAS

Assay Products for FAS:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for FAS (Fas/TNFRSF6/CD95) (see all)
	GenScript Custom Assay Services for FAS
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FAS

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FAS for domains About GeneDecksing

4 InterPro domains/families:

IPR011029 DEATH-like_dom

IPR001368 TNFR/NGFR_Cys_rich_reg

IPR008063 Fas_rcpt

IPR000488 Death_domain

Graphical View of Domain Structure for InterPro Entry P25445

ProtoNet protein and cluster: P25445

3 Blocks protein families:

IPB000488 Death domain

IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

IPB008063 FAS/CD95 receptor family signature

UniProtKB/Swiss-Prot: TNR6_HUMAN, P25445

Domain: Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins

Similarity: Contains 1 death domain

Similarity: Contains 3 TNFR-Cys repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TNR6_HUMAN, P25445

Function: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The

resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the

subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may

have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.

The secreted isoforms 2 to 6 block apoptosis (in vitro)

miRNA Products:		miRTarBase miRNAs that target FAS: hsa-mir-146a (MIRT005581)

		OriGene 3'-UTR Clone (see all 3): FAS Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FAS
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate FAS (see all 17):
		hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-374c hsa-let-7g hsa-let-7a hsa-miR-23a hsa-miR-98

		SwitchGear 3'UTR luciferase reporter plasmid: FAS 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAS (see all 7) OriGene shRNA RFP: FAS OriGene siRNA: FAS
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAS

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for FAS

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAS (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAS (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): FAS (NM_000043)
		Sino Biological Human cDNA Clone for FAS
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAS
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAS

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FAS
		Search LifeMap BioReagents cell lines for FAS

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAS

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004871	signal transducer activity	TAS	9360929
GO:0004872	receptor activity	NAS	7533181
GO:0004888	transmembrane signaling receptor activity	IEA	--
GO:0005031	tumor necrosis factor-activated receptor activity	--	--
GO:0005515	protein binding	IPI	--

FAS for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for FAS: Fas^tm1Dlo Fas^tm1.1Cgn
     15/23 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Fas) (see all 23):

behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary
endocrine/exocrine gland	growth/size	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism
immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging

FAS for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/33 super-pathways (see all 33) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptosis and survival_Caspase cascade

Apoptosis and survival_Caspase cascade	1.00	Apoptosis and survival FAS signaling cascades	0.44
Apoptosis and survival Caspase cascade	1.00	FAS pathway and Stress induction of HSP regulation	0.33
Apoptosis and survival_FAS signaling cascades	0.44

Death Receptor Signalling

	Death Receptor Signalling	1.00			Dimerization of procaspase-8	0.75
	Extrinsic Pathway for Apoptosis	1.00			Caspase-8 activation	0.75

Allograft rejection

	Allograft rejection	1.00			Graft-versus-host disease	0.63
	Type I diabetes mellitus	0.67			Autoimmune thyroid disease	0.60

Apoptosis and survival_Apoptotic TNF-family pathways

	Apoptosis and survival_Apoptotic TNF-family pathways	1.00			Apoptosis Signaling Pathways	0.35
	Apoptosis and survival Apoptotic TNF-family pathways	1.00

Development HGF signaling pathway

Development HGF signaling pathway

1.00

Development_HGF signaling pathway

0.78

Pathway sources
See GeneCards unified pathways
Show all pathways

5/7 EMD Millipore Pathways for FAS (see all 7)

	Development HGF signaling pathway
	Apoptosis and survival Caspase cascade
	Proteolysis Putative SUMO-1 pathway
	Apoptosis and survival FAS signaling cascades
	Signal transduction JNK pathway

4 R&D Systems Pathways for FAS

	TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions
	Apoptosis Signaling Pathways
	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types
	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types

3 Cell Signaling Technology (CST) Pathways for FAS

	Apoptosis and Autophagy
	Lymphocyte Signaling
	NF-kappaB Signaling

5/9 GeneGo (Thomson Reuters) Pathways for FAS (see all 9)

	Immune response Bacterial infections in normal airways
	Apoptosis and survival Caspase cascade
	Apoptosis and survival FAS signaling cascades
	Bacterial infections in CF airways
	Apoptosis and survival Apoptotic TNF-family pathways

5/14 BioSystems Pathways for FAS (see all 14)

	FAS pathway and Stress induction of HSP regulation
	Adipogenesis
	Apoptosis
	Apoptosis Modulation and Signaling
	MAPK signaling pathway

5/6 Reactome Pathways for FAS (see all 6)

	Death Receptor Signalling
	FasL/ CD95L signaling
	Extrinsic Pathway for Apoptosis
	Caspase-8 activation
	Dimerization of procaspase-8

5/15 Kegg Pathways (Kegg details for FAS) (see all 15):

	MAPK signaling pathway
	Cytokine-cytokine receptor interaction
	p53 signaling pathway
	Apoptosis
	Natural killer cell mediated cytotoxicity

FAS for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FAS

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/98 Interacting proteins for FAS (P25445^{1, 2, 3} ENSP00000347979⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 98)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTPN13	Q12923²^,³, ENSP00000394794⁴	MINT-8310831 MINT-8310795 MINT-8310858 MINT-8310845 MINT-8283218 MINT-8310809 MINT-8310820 MINT-8283266 I2D: score=5 STRING: ENSP00000394794
FADD	Q13158¹^,²^,³, ENSP00000301838⁴	EBI-494743,EBI-494804 MINT-1956556 MINT-18737 MINT-1787390 MINT-4055373 MINT-4055358 I2D: score=9 STRING: ENSP00000301838
CASP8	Q14790¹^,²^,³, ENSP00000351273⁴	EBI-494743,EBI-78060 MINT-1956415 MINT-4055373 MINT-4055317 I2D: score=9 STRING: ENSP00000351273
CALM2	P62158¹^,³	EBI-494743,EBI-397435 I2D: score=5
CALM3	P62158¹^,³	EBI-494743,EBI-397435 I2D: score=5

About this table

Gene Ontology (GO): 5/47 biological process terms (GO ID links to tree view) (see all 47): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	--	--
GO:0002377	immunoglobulin production	IEA	--
GO:0003014	renal system process	IEA	--
GO:0006461	protein complex assembly	TAS	10875918
GO:0006915	apoptotic process	TAS	--

FAS for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FAS for compounds About GeneDecksing

EMD Millipore small molecules for FAS:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAS
10/143 Novoseek chemical compound relationships for FAS gene (see all 143) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cerulenin	68.3	33	8631008 (4), 15806173 (2), 14767544 (2), 18410446 (2) (see all 19)
dutp	67.6	15	9212738 (1), 10383736 (1), 12210368 (1), 12957613 (1) (see all 13)
concanamycin a	63.9	1	11096347 (1)
safrole oxide	62.5	7	16225864 (2), 16702019 (2), 16326105 (1), 16473419 (1)
ceramide	62.4	87	10745271 (3), 11973615 (3), 18613813 (2), 11502750 (2) (see all 51)
fatty acid	56.9	276	8631008 (8), 18056164 (6), 14767544 (5), 15607568 (5) (see all 99)
cycloheximide	55.3	49	9832422 (2), 12861043 (2), 10568818 (2), 11779361 (2) (see all 33)
7-aminoactinomycin d	50.2	4	11030869 (1), 11380462 (1), 18419713 (1)
annexin-v	49.4	1	12480581 (1)
c2ceramide	48.7	15	11536010 (3), 10830777 (2), 17440345 (1), 10886239 (1) (see all 7)

Search CenterWatch for drugs/clinical trials and news about FAS / TNR6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FAS gene (8 alternative transcripts):

NM_000043.4 NM_152871.2 NM_152872.2 NM_152873.1 NM_152874.1 NM_152875.1 NM_152876.1 NM_152877.1

Unigene Cluster for FAS:

Fas (TNF receptor superfamily, member 6)

Hs.244139 [show with all ESTs]

Unigene Representative Sequence: AB209361

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000355740(uc010qna.2 uc001kfr.3 uc001kft.3 uc010qnb.2 uc001kfs.3 uc010qnc.2 uc010qnd.2 uc010qne.2 uc001kfw.3 uc009xtp.3)

ENST00000352159 ENST00000484444 ENST00000357339 ENST00000488877 ENST00000494410

ENST00000479522 ENST00000492756 ENST00000355279 ENST00000460510 ENST00000477270

ENST00000313771 ENST00000466081 ENST00000371857 ENST00000494799 ENST00000487314

miRNA Products:		OriGene 3'-UTR Clone (see all 3): FAS Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FAS
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate FAS (see all 17):
		hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-374c hsa-let-7g hsa-let-7a hsa-miR-23a hsa-miR-98

		SwitchGear 3'UTR luciferase reporter plasmid: FAS 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAS (see all 7) OriGene shRNA RFP: FAS OriGene siRNA: FAS
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAS

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAS (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAS (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): FAS (NM_000043)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAS
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAS

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAS Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FAS
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAS
		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAS

Additional cDNA sequence:

AB209361.1 AK290978.1 AK311164.1 AK311424.1 AK311499.1 AY495076.1 BC012479.1 CR450307.1

EU481974.1 FJ373045.1 FJ373046.1 FM246457.1 FM246458.1 FM246459.1 M67454.1 NR_028033.2

NR_028034.2 NR_028035.2 NR_028036.2 NR_028371.1 X63717.1 X83490.1 X83491.1 X83492.1

X83493.1 X89101.1 Z47993.1 Z47994.1 Z47995.1 Z66556.1 Z70519.1 Z70520.1

19 DOTS entries:

DT.455842 DT.100031255 DT.100031258 DT.100728449 DT.86821059 DT.95269153 DT.100689381 DT.100689391

DT.100031256 DT.121212588 DT.100779824 DT.95269151 DT.121212505 DT.95308040 DT.121212594 DT.121212597

DT.121212598 DT.95229610 DT.113385

24/109 AceView cDNA sequences (see all 109):

BC012479 X83492 AA550824 BM790665 NM_152876 N45281 W51756 CB266238

NM_152877 AA293571 BM976104 BX113824 BQ000413 AL542093 NM_152871 NM_000043

CB135078 X63717 AA521286 CR625848 BE501338 X83493 BE856244 M67454

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for FAS (see all 12) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3a	·	3b	·	3c	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b
SP1:									-		-		-		-		-												-
SP2:									-		-		-		-		-												-		-
SP3:																							-		-				-
SP4:									-		-		-		-		-						-		-				-
SP5:									-		-		-		-		-				-		-		-				-

ECgene alternative splicing isoforms for FAS

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAAACCTGC

About this image

FAS expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FAS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAS

SOURCE GeneReport for Unigene cluster: Hs.244139

UniProtKB/Swiss-Prot: TNR6_HUMAN, P25445

Tissue specificity: Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear

cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6

SABiosciences Expression via Pathway-Focused PCR Arrays including FAS (see all 24):

Cell Surface Markers in human mouse rat

Nitric Oxide Signaling Pathway in human mouse rat

Autophagy in human mouse rat

T-cell & B-cell Activation in human mouse rat

Stress & Toxicity PathwayFinder in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAS Browse OriGene validated miRNA SYBR primer pairs
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		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAS

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAS

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FAS gene from 4/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Fas^{1 , 5}	Fas (TNF receptor superfamily member 6)^{1, 5}	65.64(n)¹ 50.61(a)¹		19 (29.48 cM)⁵ 14102¹ NM_007987.2¹ NP_032013.2¹ 34290659⁵
chicken (Gallus gallus)	Aves	FAS¹	Fas (TNF receptor superfamily, member 6)	50.5(n) 37.21(a)		395274 NM_001199487.1 NP_001186416.1
lizard (Anolis carolinensis)	Reptilia	FAS⁶	--	37(a)	1 ↔ 1	GL343246.1(130333-141781)
zebrafish (Danio rerio)	Actinopterygii	fas¹	Fas (TNF receptor superfamily, member 6)	47.23(n) 32.34(a)		768248 XM_685355.3 XP_690447.3

ENSEMBL Gene Tree for FAS (if available)
TreeFam Gene Tree for FAS (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FAS gene

TNFRSF10B² TNFRSF10C² TNFRSF10A² TNFRSF10D²

2 SIMAP similar genes for FAS using alignment to 6 protein entries: TNR6_HUMAN (see all proteins):

TNFRSF6 CD95

FAS for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs28929498^1,2	C	pathogenic	103831197(+)	`AATAGA/TTGAGA`	9	D V	mis¹ ut3¹		2	NA	4
rs9658692^1,2	C	--	84390648(+)	`agtggT/Ctacca`	7	--	int¹		1	NS	172
rs9658693^1,2	F	--	84390764(+)	`tgtctA/Gtagct`	7	--	int¹		1	NS	172
rs9658694^1,2	C,F,	--	84390825(+)	`ttctcG/Accaca`	7	--	int¹		4	NS WA CSA	292
rs9658695^1,2	H	--	84390946(+)	`taattC/Taagac`	7	--	int¹		5	NS EA	592
rs9658696^1,2	C,F,H,	--	84391043(+)	`AGGTAG/ATGGCC`	7	--	int¹		5	NS EA	554
rs9658697^1,2	C,F,	--	84391051(+)	`GCCACA/CGGCAG`	7	--	int¹		1	NS	172
rs9658698^1,2	C,F,H,	--	84391114(+)	`TATTCT/GTGTAT`	7	--	int¹		5	NS EA	582
rs9658699^1,2	C,F,H,	--	84391161(+)	`GGGCTG/ATATTT`	7	--	int¹		5	NS EA	594
rs9658700^1,2	H	--	84391312(+)	`AGTCTA/GTAAAA`	7	--	int¹		5	NS EA	586

HapMap Linkage Disequilibrium report for FAS (90750288 - 90775542 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAS: --
Human Gene Mutation Database (HGMD): FAS

Locus Specific Mutation Databases (LSDB): FAS

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAS

DNA2.0 Custom Variant and Variant Library Synthesis for FAS

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FAS for disorders           About GeneDecksing

OMIM gene information: 134637 603188 607499
OMIM disorders: 601859
UniProtKB/Swiss-Prot: TNR6_HUMAN, P25445

Defects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:601859]; also

known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia

with massive lymphadenopathy and splenomegaly

20/344 diseases for FAS (see all 344): About MalaCards

squamous cell carcinoma, burn scar-related, somatic vogt-koyanagi-harada disease htlv-1 associated myelopathy purine nucleoside phosphorylase deficiency

nucleoside phosphorylase deficiency autoimmune lymphoproliferative syndrome, type ia toxic epidermal necrolysis caspase-8 deficiency

stevens-johnson syndrome marginal zone b-cell lymphoma lymphomatoid papulosis graft versus host disease

intestinal pseudo-obstruction adult-onset still's disease autoimmune lymphoproliferative syndrome relapsing-remitting multiple sclerosis

b-cell non-hodgkin lymphoma lumbar disc degeneration churg-strauss syndrome serous cystadenocarcinoma

1 disease from the University of Copenhagen DISEASES database for FAS:

Autoimmune lymphoproliferative syndrome

10/93 Novoseek disease relationships for FAS gene (see all 93) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
autoimmune lymphoproliferative syndrome	90.8	102	15640690 (3), 10340403 (2), 17605793 (2), 9028321 (2) (see all 65)
necrosis	80.5	899	15940614 (6), 10887332 (5), 11782299 (3), 15195900 (3) (see all 99)
tumors	76.7	1787	12222835 (8), 11150435 (7), 11692157 (6), 12480581 (6) (see all 99)
dianzani autoimmune lymphoproliferative disease	69	1	16537120 (1)
autoimmune diseases	63.4	83	9826578 (2), 10548879 (2), 9862736 (2), 11791468 (2) (see all 59)
autoimmunity	60.9	63	11318598 (2), 12930371 (2), 11256883 (2), 8929361 (2) (see all 41)
tumor escape	58.7	6	10383736 (1), 15968727 (1), 10415870 (1), 11523216 (1) (see all 5)
cancer	58.5	343	15577743 (6), 20505730 (6), 12498219 (3), 11323104 (3) (see all 99)
toxic epidermal necrolysis	53.9	13	10951228 (2), 11103436 (2), 12655300 (1), 17460400 (1) (see all 11)
hashimotos thyroiditis	53.8	43	14585083 (3), 12480911 (3), 10917176 (3), 9396343 (2) (see all 25)

GeneTests: FAS

Autoimmune Lymphoproliferative Syndrome

Genetic Association Database (GAD): FAS
Human Genome Epidemiology (HuGE) Navigator: FAS (234 documents)

Export disorders for FAS gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FAS gene, integrated from 9 sources (see all 3613):
(articles sorted by number of sources associating them with FAS)

Utopia: connect your pdf to the dynamic
world of online information

Somatic Fas mutations in non-Hodgkin's lymphoma: association with extranodal disease and autoimmunity. (PubMed id 9787134)^{1, 2, 4, 9} Groenbaek K.... Guldberg P. (1998)
Autoimmune lymphoproliferative syndrome with defective Fas: genotype influences penetrance. (PubMed id 10090885)^{1, 2, 9} Jackson C.E.... Puck J.M. (1999)
Functional polymorphisms in cell death pathway genes FAS and FASL contribute to risk of lung cancer. (PubMed id 15937082)^{1, 4, 9} Zhang X....Lin D. (2005)
Genetic polymorphisms of Fas (CD95) and Fas ligand (CD178) influence the rise in CD4+ T cell count after antiretroviral therapy in drug-naive HIV-positive patients. (PubMed id 16158329)^{1, 4, 9} Nasi M....Cossarizza A. (2005)
Somatic mutations of Fas (Apo-1/CD95) gene in cutaneous squamous cell carcinoma arising from a burn scar. (PubMed id 10620127)^{1, 2, 9} Lee S.H.... Yoo N.J. (2000)
The Fas-FADD death domain complex structure unravels signalling by receptor clustering. (PubMed id 19118384)^{1, 2, 9} Scott F.L....Riedl S.J. (2009)
The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis. (PubMed id 11418480)^{1, 2, 9} Straus S.E.... Lenardo M.J. (2001)
FAS promoter polymorphisms correlate with activity grade in hepatitis C patients. (PubMed id 16148554)^{1, 4, 9} McIlroy D....Poynard T. (2005)
Fas gene promoter polymorphisms in primary Sjogren's syndrome. (PubMed id 14672901)^{1, 4, 9} Mullighan C.G....Bardy P.G. (2004)
Fas promoter -670 polymorphism is associated with development of anti-RNP antibodies in systemic lupus erythematosus. (PubMed id 11550967)^{1, 4, 9} Lee Y.H....Song G.G. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 355	HGNC: 11920	AceView: TNFRSF6	Ensembl:ENSG00000026103	euGenes: HUgn355
ECgene: FAS	Kegg: 355	H-InvDB: FAS

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FAS	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FAS	Genetics and Cytogenetics in Oncology and Haematology
Autoimmune Lymphoproliferative Syndrome Database (ALPSbase)	http://research.nhgri.nih.gov/ALPS/alpsIa_mut.shtml
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/FAS
NIEHS-SNPs	http://egp.gs.washington.edu/data/tnfrsf6/

Intellectual Property for FAS gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for FAS gene:
Search GeneIP for patents involving FAS

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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In Situ Hybridization Assays from
Advanced Cell Diagnostics
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FAS Gene

Fas (TNF receptor superfamily, member 6)

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FAS (Gene Symbol)
Fas (TNF Receptor Superfamily, Member 6)
APT1
TNFRSF6
FAS1
CD95
APO-1
Tumor Necrosis Factor Receptor Superfamily, Member 6
Apoptosis-Mediating Surface Antigen FAS
CD95 Antigen
FASLG Receptor
ALPS1A
FASTM
APO-1 Cell Surface Antigen
Apoptosis Antigen 1
Delta Fas/APO-1/CD95
FAS 827dupA
Fas AMA
Tumor Necrosis Factor Receptor Superfamily Member 6
Apo-1 Antigen

Leukemia B-Cell
Leukemia T-Cell
Hepatitis Chronic
Lymphoma T-Cell
ADENOCARCINOMA LUNG
COLON CARCINOMA
LUNG CARCINOMA
Liver diseases
Breast Cancer
Sjogrens Syndrome Primary
NSCLC
Adenocarcinoma
cell damage
Cancer
Colorectal Carcinoma
HEPATITIS FULMINANT
ADENOCARCINOMA GASTRIC
Lymphoma
Carcinoma Non-Small Cell Lung
Splenomegaly
Silicosis
GASTRIC CARCINOMA
Ovarian Cancer
COLON ADENOCARCINOMA
Burkitt Lymphoma
Cowpox
Inflammation
Monocytic leukemia
immunodeficiency
DIANZANI AUTOIMMUNE LYMPHOPROLIFERATIVE DISEASE
MYELOMA
Hypergammaglobulinemia
LIVER DAMAGE
Rheumatoid Arthritis
prostate cancer
Hepatitis Autoimmune
Tumors
Vogt-Koyanagi-Harada Disease
Metastasis
Lymphomatoid Papulosis
Autoimmunity
Necrosis
Glioblastoma
Viral hepatitis
Lymphoma T-Cell Cutaneous
virus infection
Malignant Glioma
Hepatitis C
ESOPHAGEAL TUMOR
Gastric Cancer
Stevens-Johnson Syndrome
Myeloid Leukemia
Autoimmune Diseases
Lymphadenopathy
Melanoma
BREAST CARCINOMA
Colon Cancer
Toxic Epidermal Necrolysis
Glioma
Carcinoma
epithelial tumor
Leukemia
PROSTATE CARCINOMA
Osteosarcoma
Tumor Escape
Sjogrens Syndrome
HEPATOCELLULAR CARCINOMA
Lymphopenia
Carcinoma Renal Cell
Cancer Lung
AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME
Lymphoma B-Cell
cytopenia
HIV Infections
Keloid
OVARIAN CARCINOMA
Lymphoproliferative Disorders
Lymphocytic Leukemia Chronic B-Cell
autoimmune thyroid disease
Carcinoma Squamous Cell
Hepatitis C Chronic
Autoimmune Response
Graves Disease
PANCREATIC CARCINOMA
Anemia Aplastic
Graft-Versus-Host Disease
Hashimotos Thyroiditis
Lymphoma Non-Hodgkins
LYMPHOPROLIFERATIVE SYNDROME
THYROID CARCINOMA
Myelodysplastic Syndromes
LEUKAEMIA LYMPHOCYTIC
Lupus Erythematosus Systemic

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FAS Gene

Fas (TNF receptor superfamily, member 6)

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