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Aliases for FARSB Gene

Aliases for FARSB Gene

  • Phenylalanyl-TRNA Synthetase, Beta Subunit 2 3
  • Phenylalanyl-TRNA Synthetase-Like, Beta Subunit 2 3
  • EC 6.1.1.20 4 63
  • FARSLB 3 4
  • PheRS 3 4
  • FRSB 3 4
  • Phenylalanine-TRNA Synthetase-Like, Beta Subunit 3
  • Phenylalanine TRNA Ligase 1, Beta, Cytoplasmic 3
  • Phenylalanyl-TRNA Synthetase Beta-Subunit 3
  • Phenylalanyl-TRNA Synthetase Beta Subunit 4
  • Phenylalanyl-TRNA Synthetase Beta Chain 3
  • Phenylalanine--TRNA Ligase Beta Chain 3
  • Phenylalanine-TRNA Ligase Beta Chain 3
  • Phenylalanine TRNA Ligase 1 2
  • Cytoplasmic 2
  • EC 6.1.1 63
  • HSPC173 3
  • PheHB 3
  • Beta 2

External Ids for FARSB Gene

Previous HGNC Symbols for FARSB Gene

  • FARSLB

Previous GeneCards Identifiers for FARSB Gene

  • GC02M223144
  • GC02M223435
  • GC02M215289

Summaries for FARSB Gene

Entrez Gene Summary for FARSB Gene

  • This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for FARSB Gene

FARSB (Phenylalanyl-TRNA Synthetase, Beta Subunit) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include RNA binding and magnesium ion binding. An important paralog of this gene is LRRC47.

Gene Wiki entry for FARSB Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FARSB Gene

Genomics for FARSB Gene

Regulatory Elements for FARSB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FARSB Gene

Chromosome:
2
Start:
222,570,536 bp from pter
End:
222,656,355 bp from pter
Size:
85,820 bases
Orientation:
Minus strand

Genomic View for FARSB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for FARSB Gene

Proteins for FARSB Gene

  • Protein details for FARSB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSD9-SYFB_HUMAN
    Recommended name:
    Phenylalanine--tRNA ligase beta subunit
    Protein Accession:
    Q9NSD9
    Secondary Accessions:
    • B4DFM0
    • O95708
    • Q4ZFX1
    • Q57ZJ5
    • Q9NZZ6

    Protein attributes for FARSB Gene

    Size:
    589 amino acids
    Molecular mass:
    66116 Da
    Quaternary structure:
    • Tetramer of two alpha and two beta subunits.

    Three dimensional structures from OCA and Proteopedia for FARSB Gene

    Alternative splice isoforms for FARSB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FARSB Gene

Proteomics data for FARSB Gene at MOPED

Selected DME Specific Peptides for FARSB Gene

Post-translational modifications for FARSB Gene

  • Ubiquitination at Lys 64, Lys 329, and Lys 560
  • Modification sites at PhosphoSitePlus

Other Protein References for FARSB Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for FARSB Gene

Gene Families for FARSB Gene

Graphical View of Domain Structure for InterPro Entry

Q9NSD9

UniProtKB/Swiss-Prot:

SYFB_HUMAN :
  • Contains 1 B5 domain.
  • Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
Domain:
  • Contains 1 B5 domain.
Family:
  • Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
genes like me logo Genes that share domains with FARSB: view

Function for FARSB Gene

Molecular function for FARSB Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)

Enzyme Numbers (IUBMB) for FARSB Gene

Gene Ontology (GO) - Molecular Function for FARSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0000287 magnesium ion binding IEA --
GO:0003723 RNA binding IEA --
GO:0004826 phenylalanine-tRNA ligase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with FARSB: view

Phenotypes for FARSB Gene

genes like me logo Genes that share phenotypes with FARSB: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FARSB

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for FARSB Gene

Localization for FARSB Gene

Subcellular locations from UniProtKB/Swiss-Prot for FARSB Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FARSB Gene COMPARTMENTS Subcellular localization image for FARSB gene
Compartment Confidence
cytosol 4
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FARSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 10049785
GO:0005829 cytosol TAS --
GO:0009328 phenylalanine-tRNA ligase complex IBA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with FARSB: view

Pathways & Interactions for FARSB Gene

genes like me logo Genes that share pathways with FARSB: view

Pathways by source for FARSB Gene

1 KEGG pathway for FARSB Gene

Gene Ontology (GO) - Biological Process for FARSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS 10049785
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006432 phenylalanyl-tRNA aminoacylation IBA --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with FARSB: view

No data available for SIGNOR curated interactions for FARSB Gene

Drugs & Compounds for FARSB Gene

(6) Drugs for FARSB Gene - From: NovoSeek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Phenylalanine Approved Nutra Target 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0
ATP Pharma Activator 0

(4) Additional Compounds for FARSB Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Anticodon
tRNA
tRNA(Phe)
genes like me logo Genes that share compounds with FARSB: view

Transcripts for FARSB Gene

Unigene Clusters for FARSB Gene

Phenylalanyl-tRNA synthetase, beta subunit:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FARSB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FARSB Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for FARSB Gene

GeneLoc Exon Structure for
FARSB
ECgene alternative splicing isoforms for
FARSB

Expression for FARSB Gene

mRNA expression in normal human tissues for FARSB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FARSB Gene

This gene is overexpressed in Breast (7.1) and Peripheral blood mononuclear cells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FARSB Gene



SOURCE GeneReport for Unigene cluster for FARSB Gene Hs.471452

genes like me logo Genes that share expression patterns with FARSB: view

Protein tissue co-expression partners for FARSB Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FARSB Gene

Orthologs for FARSB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FARSB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FARSB 35
  • 90.21 (n)
  • 93.89 (a)
FARSB 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FARSB 35
  • 92.64 (n)
  • 95.08 (a)
-- 36
  • 75 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Farsb 35
  • 87.27 (n)
  • 93.55 (a)
Farsb 16
Farsb 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FARSB 35
  • 99.6 (n)
  • 99.49 (a)
FARSB 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Farsb 35
  • 87.72 (n)
  • 93.38 (a)
oppossum
(Monodelphis domestica)
Mammalia FARSB 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
chicken
(Gallus gallus)
Aves FARSB 35
  • 78.12 (n)
  • 82.31 (a)
FARSB 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FARSB 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia farsb 35
  • 72.23 (n)
  • 79.22 (a)
African clawed frog
(Xenopus laevis)
Amphibia frsb-prov 35
zebrafish
(Danio rerio)
Actinopterygii farsb 35
  • 69.9 (n)
  • 76.19 (a)
farsb 36
  • 76 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9004 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003517 35
  • 59.73 (n)
  • 62.63 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5706 35
  • 60.52 (n)
  • 62.97 (a)
CG5706 36
  • 62 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea fars-3 35
  • 59.98 (n)
  • 59.69 (a)
fars-3 36
  • 58 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR219W 35
  • 53.39 (n)
  • 48.35 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D05137g 35
  • 54.67 (n)
  • 50.26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FRS1 35
  • 54.2 (n)
  • 48.35 (a)
FRS1 36
  • 46 (a)
OneToMany
FRS1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G72550 35
  • 57.95 (n)
  • 50.94 (a)
soybean
(Glycine max)
eudicotyledons Gma.2819 35
barley
(Hordeum vulgare)
Liliopsida Hv.8880 35
rice
(Oryza sativa)
Liliopsida Os.5132 35
Os05g0558900 35
  • 55.44 (n)
  • 51.53 (a)
corn
(Zea mays)
Liliopsida Zm.12166 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1025 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08888 35
  • 52.27 (n)
  • 49.4 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes frs1 35
  • 53.57 (n)
  • 48.42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2834 36
  • 57 (a)
OneToOne
Species with no ortholog for FARSB:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FARSB Gene

ENSEMBL:
Gene Tree for FARSB (if available)
TreeFam:
Gene Tree for FARSB (if available)

Paralogs for FARSB Gene

Paralogs for FARSB Gene

(1) SIMAP similar genes for FARSB Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for FARSB Gene

genes like me logo Genes that share paralogs with FARSB: view

Variants for FARSB Gene

Sequence variations from dbSNP and Humsavar for FARSB Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs7185 - 222,571,888(+) TCCAA(C/T)ATTGA missense, reference, nc-transcript-variant
rs868392 -- 222,652,540(-) CCCCA(A/G)ATGGA intron-variant
rs874363 -- 222,609,911(+) AAGAC(A/G)TGCTT intron-variant
rs874364 -- 222,610,028(+) GGTAC(A/T)TTCTC intron-variant
rs876175 -- 222,611,457(+) GGGGC(A/G)CGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FARSB Gene

Variant ID Type Subtype PubMed ID
nsv834551 CNV Gain+Loss 17160897
esv2585241 CNV Deletion 19546169
esv2721518 CNV Deletion 23290073
esv2377277 CNV Deletion 18987734
esv3729 CNV Deletion 18987735
esv2721519 CNV Deletion 23290073
dgv20e197 CNV Deletion 19546169
esv1000228 CNV Deletion 20482838
esv1232411 CNV Deletion 17803354
esv5526 CNV Loss 19470904

Variation tolerance for FARSB Gene

Residual Variation Intolerance Score: 27.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FARSB Gene

HapMap Linkage Disequilibrium report
FARSB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FARSB Gene

Disorders for FARSB Gene

Relevant External Links for FARSB

Genetic Association Database (GAD)
FARSB
Human Genome Epidemiology (HuGE) Navigator
FARSB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FARSB
genes like me logo Genes that share disorders with FARSB: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FARSB Gene

Publications for FARSB Gene

  1. Structural basis for discrimination of L-phenylalanine from L-tyrosine by phenylalanyl-tRNA synthetase. (PMID: 16338408) Kotik-Kogan O. … Safro M. (Structure 2005) 23 25 26 67
  2. Human phenylalanyl-tRNA synthetase: cloning, characterization of the deduced amino acid sequences in terms of the structural domains and coordinately regulated expression of the alpha and beta subunits in chronic myeloid leukemia cells. (PMID: 10049785) Rodova M. … Safro M.G. (Biochem. Biophys. Res. Commun. 1999) 2 23 67
  3. Cell-specific differences in the requirements for translation quality control. (PMID: 20160120) Reynolds N.M. … Ibba M. (Proc. Natl. Acad. Sci. U.S.A. 2010) 23 67
  4. Large-scale movement of functional domains facilitates aminoacylation by human mitochondrial phenylalanyl-tRNA synthetase. (PMID: 19737557) Yadavalli S.S. … Ibba M. (FEBS Lett. 2009) 23 67
  5. The tRNA-induced conformational activation of human mitochondrial phenylalanyl-tRNA synthetase. (PMID: 18611382) Klipcan L. … Safro M. (Structure 2008) 23 67

Products for FARSB Gene

Sources for FARSB Gene

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