Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FARSB Gene

protein-coding   GIFtS: 61
GCID: GC02M223435

Phenylalanyl-TRNA Synthetase, Beta Subunit

(Previous names: phenylalanyl-tRNA synthetase-like, beta subunit)
(Previous symbol: FARSLB)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Phenylalanyl-TRNA Synthetase, Beta Subunit1 2     Phenylalanine TRNA Ligase 1, Beta, Cytoplasmic2
FARSLB1 2 3 5     Phenylalanine--TRNA Ligase Beta Chain2
FRSB2 3 5     Phenylalanine--TRNA Ligase Beta Subunit2
Phenylalanyl-TRNA Synthetase-Like, Beta Subunit1 2     Phenylalanine-TRNA Ligase Beta Chain2
PheRS2 3     Phenylalanine-TRNA Synthetase-Like, Beta Subunit2
EC 6.1.1.203 8     Phenylalanyl-TRNA Synthetase Beta Chain2
beta1     Phenylalanyl-TRNA Synthetase Beta-Subunit2
cytoplasmic1     Phenylalanyl-TRNA Synthetase Beta Subunit3
Phenylalanine TRNA Ligase 11     EC 6.1.18
PheHB2     

External Ids:    HGNC: 178001   Entrez Gene: 100562   Ensembl: ENSG000001161207   OMIM: 6096905   UniProtKB: Q9NSD93   

Export aliases for FARSB gene to outside databases

Previous GC identifers: GC02M223144 GC02M215289


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FARSB Gene:
This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily.
This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the
presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the
appropriate tRNA. A pseudogene located on chromosome 10 has been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for FARSB Gene:
FARSB (phenylalanyl-tRNA synthetase, beta subunit) is a protein-coding gene. GO annotations related to this gene include phenylalanine-tRNA ligase activity and RNA binding. An important paralog of this gene is LRRC47.

Gene Wiki entry for FARSB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FARSB gene promoter:
         NF-1   NF-1/L   LUN-1   GATA-1   POU2F1   HOXA5   FOXJ2 (long isoform)   POU2F1a   FOXJ2   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFARSB promoter sequence
   Search Chromatin IP Primers for FARSB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FARSB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.1   Ensembl cytogenetic band:  2q36.1   HGNC cytogenetic band: 2q36.2

FARSB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FARSB gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M223435:  view genomic region     (about GC identifiers)

Start:
223,435,255 bp from pter      End:
223,521,056 bp from pter
Size:
85,802 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SYFB_HUMAN, Q9NSD9 (See protein sequence)
Recommended Name: Phenylalanine--tRNA ligase beta subunit  
Size: 589 amino acids; 66116 Da
Subunit: Tetramer of two alpha and two beta subunits (By similarity)
1 PDB 3D structure from and Proteopedia for FARSB:
3L4G (3D)    
Secondary accessions: O95708 Q4ZFX1 Q57ZJ5 Q9NZZ6

Explore the universe of human proteins at neXtProt for FARSB: NX_Q9NSD9

Explore proteomics data for FARSB at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys64, Lys329, Lys560
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for FARSB (Q9NSD9) (see all 9)
     IKFKPLN  VKRDLLF  EKLHQNI  SMPPIIN 


    See FARSB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005678.3  
    ENSEMBL proteins: 
     ENSP00000281828   ENSP00000442950  
    Reactome Protein details: Q9NSD9

    FARSB Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for FARSB
    OriGene Protein Over-expression Lysate for FARSB
    OriGene MassSpec for FARSB
    OriGene Custom Protein Services for FARSB
    GenScript Custom Purified and Recombinant Proteins Services for FARSB
    Novus Biologicals FARSB Proteins
    Novus Biologicals FARSB Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for FARSB 

     
    antibodies-online proteins for FARSB (6 products) 

     
    antibodies-online peptides for FARSB

    FARSB Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FARSB
    Novus Biologicals FARSB Antibodies
    Search for Antibodies for FARSB at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for FARSB
    antibodies-online antibodies for FARSB (30 products) 

    FARSB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FARSB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FARSB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for FARSB 
    antibodies-online kits for FARSB (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    aaRS2: Aminoacyl tRNA synthetases / Class II

    5 InterPro protein domains:
     IPR009061 DNA-bd_dom_put
     IPR020825 Phe-tRNA_synthase_B3/B4
     IPR004531 Phe-tRNA-synth_IIc_bsu_arc
     IPR005146 B3/B4_tRNA-bd
     IPR005147 tRNA_synthase_B5-dom

    Graphical View of Domain Structure for InterPro Entry Q9NSD9

    ProtoNet protein and cluster: Q9NSD9

    1 Blocks protein domain: IPB005147 tRNA synthetase B5 domain

    UniProtKB/Swiss-Prot: SYFB_HUMAN, Q9NSD9
    Similarity: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily
    Similarity: Contains 1 B5 domain


    Find genes that share domains with FARSB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYFB_HUMAN, Q9NSD9
    Catalytic activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)

         Enzyme Numbers (IUBMB): EC 6.1.1.201 2 EC 6.1.12

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0000287magnesium ion binding IEA--
    GO:0003723RNA binding IEA--
    GO:0004826phenylalanine-tRNA ligase activity IEA--
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with FARSB           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FARSB:
     Decreased Hepatitis C virus re 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FARSB

    miRNA
    Products:
        
    miRTarBase miRNAs that target FARSB:
    hsa-mir-193b-3p (MIRT041199), hsa-mir-100-5p (MIRT048577), hsa-mir-744-5p (MIRT037617)

    Block miRNA regulation of human, mouse, rat FARSB using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate FARSB:
    hsa-miR-1197 hsa-miR-1324
    SwitchGear 3'UTR luciferase reporter plasmidFARSB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FARSB
    Predesigned siRNA for gene silencing in human, mouse, rat FARSB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FARSB

    Clone
    Products:
         
    OriGene clones in human, mouse for FARSB (see all 8)
    OriGene ORF clones in mouse, rat for FARSB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FARSB (NM_005687)
    Sino Biological Human cDNA Clone for FARSB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FARSB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FARSB

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FARSB
    Browse ESI BIO Cell Lines and PureStem Progenitors for FARSB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FARSB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SYFB_HUMAN, Q9NSD9: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion2
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS10049785
    GO:0005829cytosol TAS--

    Find genes that share ontologies with FARSB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FARSB About    
    See pathways by source

    SuperPathContained pathways About
    1tRNA Aminoacylation
    tRNA Aminoacylation0.57
    Aminoacyl-tRNA biosynthesis0.52
    Cytosolic tRNA aminoacylation0.57
    2Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with FARSB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for FARSB
        Cytosolic tRNA aminoacylation


    1 Kegg Pathway  (Kegg details for FARSB):
        Aminoacyl-tRNA biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FARSB
    Interactions:

        Search GeneGlobe Interaction Network for FARSB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FARSB (Q9NSD93 ENSP000002818284) via UniProtKB, MINT, STRING, and/or I2D (see all 72)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000096171P266403I2D: score=1 
    ENSG00000224264P266403I2D: score=1 
    ENSG00000226589P266403I2D: score=1 
    ENSG00000231116P266403I2D: score=1 
    VARSP266403I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS10049785
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006432phenylalanyl-tRNA aminoacylation IEA--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with FARSB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FARSB (SYFB)

    5 HMDB Compounds for FARSB    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Phenylalanine(-)-beta-Phenylalanine (see all 28)63-91-2--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for FARSB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Phenylalanine(S)-alpha-Amino-beta-phenylpropionic acid (see all 4)63-91-2target--16338408

    5 Novoseek inferred chemical compound relationships for FARSB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trna(phe) 91.9 10 15000681 (2), 15000680 (2), 10049785 (1), 12354112 (1)
    anticodon 80 1 10329163 (1)
    phenylalanine 71.8 3 15000680 (2), 15000681 (1)
    trna 68 13 16866361 (4), 10049785 (1), 12354112 (1)
    atp 37.6 3 15000680 (2), 15000681 (1)



    Find genes that share compounds with FARSB           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FARSB gene: 
    NM_005687.3  

    Unigene Cluster for FARSB:

    Phenylalanyl-tRNA synthetase, beta subunit
    Hs.471452  [show with all ESTs]
    Unigene Representative Sequence: D84430
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000281828(uc002vne.1 uc010zlq.1 uc002vnf.1 uc002vng.1)
    ENST00000536361
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FARSB using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate FARSB:
    hsa-miR-1197 hsa-miR-1324
    SwitchGear 3'UTR luciferase reporter plasmidFARSB 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FARSB
    Predesigned siRNA for gene silencing in human, mouse, rat FARSB
    Clone
    Products:
         
    OriGene clones in human, mouse for FARSB (see all 8)
    OriGene ORF clones in mouse, rat for FARSB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FARSB (NM_005687)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FARSB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FARSB
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FARSB
    OriGene qSTAR qPCR primer pairs in human, mouse for FARSB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FARSB
      QuantiTect SYBR Green Assays in human, mouse, rat FARSB
      QuantiFast Probe-based Assays in human, mouse, rat FARSB

    Additional mRNA sequence: 

    AF042346.1 AF161521.1 AK001025.1 AK055289.1 AK291531.1 AK294158.1 AK316497.1 BC006502.2 
    BC008434.1 BC011261.1 BC017783.1 BC022273.1 D84430.1 

    24 DOTS entries:

    DT.456191  DT.101961732  DT.102829034  DT.121035964  DT.95257210  DT.448035  DT.95261256  DT.92454348 
    DT.455759  DT.92454343  DT.92454356  DT.40123474  DT.100037018  DT.100880286  DT.121035937  DT.121035941 
    DT.121035949  DT.121035913  DT.121035953  DT.92454352  DT.92454361  DT.95257212  DT.121035975  DT.448831 

    Selected AceView cDNA sequences (see all 439):

    CR614902 AL533492 BI757773 BM798591 BM699108 BX438623 CR596774 BI870599 
    N52682 CB130550 BM967063 AA926949 BQ921822 BP371776 CB133346 BF765223 
    BG109815 BI850406 BQ082447 D84430 CB159488 BC022273 BP338042 AK055289 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FARSB    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:              -     -     -                                                                                                   
    SP2:                                                                                -                                             
    SP3:              -                                                                                                               
    SP4:                                                                                                                              


    ECgene alternative splicing isoforms for FARSB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FARSB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTGCTCCT
    FARSB Expression
    About this image


    FARSB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Thymus (Hematopoietic System)
             Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Kidney (Urinary System)
             Metanephros
    FARSB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FARSB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.471452
        Custom PCR Arrays for FARSB
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FARSB
    OriGene qSTAR qPCR primer pairs in human, mouse for FARSB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FARSB
    QuantiTect SYBR Green Assays in human, mouse, rat FARSB
    QuantiFast Probe-based Assays in human, mouse, rat FARSB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FARSB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FARSB gene from Selected species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Farsb1 , 5 phenylalanyl-tRNA synthetase, beta subunit1, 5 87.27(n)1
    93.55(a)1
      1 (40.44 cM)5
    238741  NM_001278075.11  NP_001265004.11 
     784248365 
    chicken
    (Gallus gallus)
    Aves FARSB1 phenylalanyl-tRNA synthetase, beta subunit 78.12(n)
    82.31(a)
      424812  NM_001006543.1  NP_001006543.1 
    lizard
    (Anolis carolinensis)
    Reptilia FARSB6
    phenylalanyl-tRNA synthetase, beta subunit
    80(a)
    1 ↔ 1
    3(25517832-25559251)
    African clawed frog
    (Xenopus laevis)
    Amphibia frsb-prov2 phenylalanyl-tRNA synthetase beta-subunit 76.8(n)    BC056121.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BQ479687.12   -- 73.87(n)    BQ479687.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG57061 CG5706 60.52(n)
    62.97(a)
      42888  NM_142980.4  NP_651237.1 
    worm
    (Caenorhabditis elegans)
    Secernentea fars-31 fars-3 59.98(n)
    59.69(a)
      174351  NM_063384.6  NP_495785.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FRS1(YLR060W)4
    FRS11
    Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, more4
    FRS11
    54.2(n)1
    48.35(a)1
      12(260979-262766)4
    8507491, 4  NP_013161.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G725501 AT1G72550 57.95(n)
    50.94(a)
      843587  NM_105914.4  NP_177399.1 
    rice
    (Oryza sativa)
    Liliopsida Os.51322 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 77.61(n)    AK101679.1 


    ENSEMBL Gene Tree for FARSB (if available)
    TreeFam Gene Tree for FARSB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FARSB gene
    LRRC472  
    1 SIMAP similar gene for FARSB using alignment to 3 protein entries:     SYFB_HUMAN (see all proteins):
    FARSLB

    Find genes that share paralogs with FARSB           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for FARSB
    PGOHUM00000258496


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FARSB (see all 1544)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1418197231,2
    --223435749(+) AAAAGA/GGAGGT 1 -- ds50010--------
    rs1881815021,2
    --223435754(+) AGAGGC/TCTAAT 1 -- ds50010--------
    rs1506261581,2
    --223435976(+) TCACAC/GATAGA 1 -- ds50010--------
    rs1386412141,2
    --223436054(+) ACTGAC/TCTCAG 1 -- ds50010--------
    rs1118883581,2
    C--223436184(+) ATCTCGAACT   
       CAT
    /-
    GAACT
    1 -- ut311Minor allele frequency- -:0.50CSA 2
    rs584123431,2
    C--223436185(+) TCTCG-/AACTCAT
    G
    /GAACTCAT
    AACTC
    2 -- ut311NA 2
    rs1493307361,2
    C--223436269(+) AATCCA/GTTCCA 1 -- ut310--------
    rs37689721,2
    C,H--223436358(+) CTCCAC/TGGGGC 1 -- ut31 ese34Minor allele frequency- T:0.00NS EA 420
    rs37689731,2
    C,F,A,H--223436402(+) CCACAC/TTGGTA 1 -- ut31 ese322Minor allele frequency- T:0.46EA NA NS WA CSA 2240
    rs32110181,2
    C,F,O,A,H--223436428(-) TGCATA/GTTAGG 1 -- ut31 ese322Minor allele frequency- N:0.00EA MN NA NS CSA WA 2828

    HapMap Linkage Disequilibrium report for FARSB (223435255 - 223521056 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for FARSB:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1232411CNV Deletion17803354
    esv2377277CNV Deletion18987734
    esv2585241CNV Deletion19546169
    esv2721518CNV Deletion23290073
    esv3729CNV Deletion18987735
    esv2721519CNV Deletion23290073
    esv1000228CNV Deletion20482838
    dgv20e197CNV Deletion19546169
    esv5526CNV Loss19470904
    nsv834551CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FARSB
    DNA2.0 Custom Variant and Variant Library Synthesis for FARSB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609690    OMIM disorders: --


    Find genes that share disorders with FARSB           About GenesLikeMe

    Genetic Association Database (GAD): FARSB
    Human Genome Epidemiology (HuGE) Navigator: FARSB (1 document)

    Export disorders for FARSB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FARSB gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with FARSB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human phenylalanyl-tRNA synthetase: cloning, characterization of the deduced amino acid sequences in terms of the structural domains and coordinately regulated expression of the alpha and beta subunits in chronic myeloid leukemia cells. (PubMed id 10049785)1, 2, 3, 9 Rodova M.... Safro M.G. (Biochem. Biophys. Res. Commun. 1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    5. Cloning and expression of human phenylalanyl-tRNA synthetase in Escherichia coli: comparative study of purified recombinant enzymes. (PubMed id 11858721)1, 9 Moor N....Safro M. (Protein Expr. Purif. 2002)
    6. Role of low-molecular-weight substrates in functional binding of the tRNAPhe acceptor end by phenylalanyl-tRNA synthetase. (PubMed id 15000680)1, 9 Vasil'eva I.A....Moor N.A. (Biochemistry Mosc. 2004)
    7. A series of spirocyclic analogues as potent inhibitors of bacterial phenylalanyl-tRNA synthetases. (PubMed id 14980694)1, 9 Yu X.Y....Oliver N. (amp 2004)
    8. Structural basis for discrimination of L-phenylalanine from L-tyrosine by phenylalanyl-tRNA synthetase. (PubMed id 16338408)7, 9 Kotik-Kogan O....Safro M. (Structure 2005)
    9. Cloning of the cDNA encoding phenylalanyl tRNA synthetase regulatory alpha-subunit-like protein whose expression is down-regulated during differentiation. (PubMed id 10375616)1, 9 Zhou X....Marks P.A. (Gene 1999)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10056 HGNC: 17800 AceView: FARSLB Ensembl:ENSG00000116120 euGenes: HUgn10056
    ECgene: FARSB Kegg: 10056 H-InvDB: FARSB

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FARSB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FARSB gene:
    Search GeneIP for patents involving FARSB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FARSB  
     OriGene qPCR primer pairs and template standards for FARSB   OriGene Protein Over-expression Lysate for FARSB  
     OriGene MassSpec for FARSB   OriGene clones in human, mouse for FARSB  
     OriGene qSTAR qPCR primer pairs in human, mouse for FARSB   OriGene Purified Protein for FARSB  
     OriGene ORF clones in mouse, rat for FARSB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FARSB   OriGene Custom Protein Services for FARSB  

     
     
     Block miRNA regulation of human, mouse, rat FARSB using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FARSB
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FARSB Predesigned siRNA for gene silencing in human, mouse, rat FARSB
     QuantiFast Probe-based Assays in human, mouse, rat FARSB QuantiTect SYBR Green Assays in human, mouse, rat FARSB
     Custom PCR Arrays for FARSB Search Chromatin IP Primers for FARSB
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FARSB  Search GeneGlobe Interaction Network for FARSB
     Regulatory tfbs in FARSB promoter
     GenScript Custom Purified and Recombinant Proteins Services for FARSB GenScript cDNA clones with any tag delivered in your preferred vector for FARSB
     GenScript Custom Assay Services for FARSB GenScript Custom overexpressing Cell Line Services for FARSB
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FARSB (SYFB)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for FARSB
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FARSB antibodies
     FARSB proteins
     FARSB lysates
     Search for Antibodies for FARSB at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for FARSB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for FARSB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FARSB
     SwitchGear 3'UTR luciferase reporter plasmids for FARSB
     SwitchGear Promoter luciferase reporter plasmids for FARSB
     ThermoFisher Antibody for FARSB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FARSB
     Browse compounds at ApexBio
     Search Addgene for plasmids for FARSB
      Search eBioscience for proteins for FARSB
      Search eBioscience for elisas for FARSB
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for FARSB
     antibodies-online antibodies for FARSB (30 products)
     antibodies-online kits for FARSB (4 products)
     antibodies-online peptides for FARSB
     antibodies-online proteins for FARSB (6 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FARSB gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4