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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FARSB Gene

protein-coding   GIFtS: 61
GCID: GC02M223435

Phenylalanyl-TRNA Synthetase, Beta Subunit

(Previous names: phenylalanyl-tRNA synthetase-like, beta subunit)
(Previous symbol: FARSLB)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phenylalanyl-TRNA Synthetase, Beta Subunit1 2     Phenylalanine TRNA Ligase 1, Beta, Cytoplasmic2
FARSLB1 2 3 5     Phenylalanine--TRNA Ligase Beta Chain2
FRSB2 3 5     Phenylalanine--TRNA Ligase Beta Subunit2
Phenylalanyl-TRNA Synthetase-Like, Beta Subunit1 2     Phenylalanine-TRNA Ligase Beta Chain2
PheRS2 3     Phenylalanine-TRNA Synthetase-Like, Beta Subunit2
EC 6.1.1.203 8     Phenylalanyl-TRNA Synthetase Beta Chain2
beta1     Phenylalanyl-TRNA Synthetase Beta-Subunit2
cytoplasmic1     Phenylalanyl-TRNA Synthetase Beta Subunit3
Phenylalanine TRNA Ligase 11     EC 6.1.18
PheHB2     

External Ids:    HGNC: 178001   Entrez Gene: 100562   Ensembl: ENSG000001161207   OMIM: 6096905   UniProtKB: Q9NSD93   

Export aliases for FARSB gene to outside databases

Previous GC identifers: GC02M223144 GC02M215289


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FARSB Gene:
This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily.
This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the
presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the
appropriate tRNA. A pseudogene located on chromosome 10 has been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for FARSB Gene: 
FARSB (phenylalanyl-tRNA synthetase, beta subunit) is a protein-coding gene. Diseases associated with FARSB include chronic myeloid leukemia, and myeloid leukemia, and among its related super-pathways are Cytosolic tRNA aminoacylation and Generic Transcription Pathway. GO annotations related to this gene include phenylalanine-tRNA ligase activity and RNA binding. An important paralog of this gene is LRRC47.

Gene Wiki entry for FARSB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FARSB gene promoter:
         NF-1   NF-1/L   LUN-1   GATA-1   POU2F1   HOXA5   FOXJ2 (long isoform)   POU2F1a   FOXJ2   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFARSB promoter sequence
   Search SABiosciences Chromatin IP Primers for FARSB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FARSB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.1   Ensembl cytogenetic band:  2q36.1   HGNC cytogenetic band: 2q36.2

FARSB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FARSB gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M223435:  view genomic region     (about GC identifiers)

Start:
223,435,255 bp from pter      End:
223,521,056 bp from pter
Size:
85,802 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SYFB_HUMAN, Q9NSD9 (See protein sequence)
Recommended Name: Phenylalanine--tRNA ligase beta subunit  
Size: 589 amino acids; 66116 Da
Subunit: Tetramer of two alpha and two beta subunits (By similarity)
Subcellular location: Cytoplasm (By similarity)
1 PDB 3D structure from and Proteopedia for FARSB:
3L4G (3D)    
Secondary accessions: O95708 Q4ZFX1 Q57ZJ5 Q9NZZ6

Explore the universe of human proteins at neXtProt for FARSB: NX_Q9NSD9

Explore proteomics data for FARSB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NSD9

  • 4/9 DME Specific Peptides for FARSB (Q9NSD9) (see all 9)
     IKFKPLN  VKRDLLF  EKLHQNI  SMPPIIN 

    FARSB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FARSB Protein Expression
    REFSEQ proteins: NP_005678.3  
    ENSEMBL proteins: 
     ENSP00000281828   ENSP00000442950  
    Reactome Protein details: Q9NSD9
    Human Recombinant Protein Products for FARSB: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS10049785
    GO:0005829cytosol TAS--

    FARSB for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    aaRS2: Aminoacyl tRNA synthetases / Class II

    5 InterPro protein domains:
     IPR009061 DNA-bd_dom_put
     IPR020825 Phe-tRNA_synthase_B3/B4
     IPR004531 Phe-tRNA-synth_IIc_bsu_arc
     IPR005146 B3/B4_tRNA-bd
     IPR005147 tRNA_synthase_B5-dom

    Graphical View of Domain Structure for InterPro Entry Q9NSD9

    ProtoNet protein and cluster: Q9NSD9

    1 Blocks protein domain: IPB005147 tRNA synthetase B5 domain

    UniProtKB/Swiss-Prot: SYFB_HUMAN, Q9NSD9
    Similarity: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily
    Similarity: Contains 1 B5 domain


    FARSB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYFB_HUMAN, Q9NSD9
    Catalytic activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)

         Enzyme Numbers (IUBMB): EC 6.1.1.201 2 EC 6.1.12

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0000287magnesium ion binding IEA--
    GO:0003723RNA binding IEA--
    GO:0004826phenylalanine-tRNA ligase activity IEA--
    GO:0005524ATP binding IEA--
         
    FARSB for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FARSB:
     Decreased Hepatitis C virus re 

    Animal Models:
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    hsa-miR-1197 hsa-miR-1324
    SwitchGear 3'UTR luciferase reporter plasmidFARSB 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FARSB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FARSB About                                                                                                See pathways by source

    SuperPathContained pathways About
    1tRNA Aminoacylation
    tRNA Aminoacylation0.57
    Aminoacyl-tRNA biosynthesis0.54
    Cytosolic tRNA aminoacylation0.57
    2Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for FARSB
        Cytosolic tRNA aminoacylation
    tRNA Aminoacylation
    Gene Expression


    1         Kegg Pathway  (Kegg details for FARSB):
        Aminoacyl-tRNA biosynthesis


    FARSB for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FARSB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/32 Interacting proteins for FARSB (Q9NSD93 ENSP000002818284) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000096171P266403I2D: score=1 
    ENSG00000226589P266403I2D: score=1 
    VARSP266403I2D: score=1 
    FARSAQ9Y2853, ENSP000003203094I2D: score=6 STRING: ENSP00000320309
    IARSP412523, ENSP000003647944I2D: score=3 STRING: ENSP00000364794
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS10049785
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006432phenylalanyl-tRNA aminoacylation IEA--
    GO:0010467gene expression TAS--

    FARSB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FARSB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FARSB (SYFB)

    5 HMDB Compounds for FARSB    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Phenylalanine(-)-beta-Phenylalanine (see all 28)63-91-2--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for FARSB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Phenylalanine(S)-alpha-Amino-beta-phenylpropionic acid (see all 4)63-91-2target--16338408

    5 Novoseek inferred chemical compound relationships for FARSB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trna(phe) 91.9 10 15000681 (2), 15000680 (2), 10049785 (1), 12354112 (1)
    anticodon 80 1 10329163 (1)
    phenylalanine 71.8 3 15000680 (2), 15000681 (1)
    trna 68 13 16866361 (4), 10049785 (1), 12354112 (1)
    atp 37.6 3 15000680 (2), 15000681 (1)

    Search CenterWatch for drugs/clinical trials and news about FARSB / SYFB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FARSB gene: 
    NM_005687.3  

    Unigene Cluster for FARSB:

    Phenylalanyl-tRNA synthetase, beta subunit
    Hs.471452  [show with all ESTs]
    Unigene Representative Sequence: D84430
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000281828(uc002vne.1 uc010zlq.1 uc002vnf.1 uc002vng.1)
    ENST00000536361
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate FARSB:
    hsa-miR-1197 hsa-miR-1324
    SwitchGear 3'UTR luciferase reporter plasmidFARSB 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF042346.1 AF161521.1 AK001025.1 AK055289.1 AK291531.1 AK294158.1 AK316497.1 BC006502.2 
    BC008434.1 BC011261.1 BC017783.1 BC022273.1 D84430.1 

    24 DOTS entries:

    DT.456191  DT.101961732  DT.102829034  DT.121035964  DT.95257210  DT.448035  DT.95261256  DT.92454348 
    DT.455759  DT.92454343  DT.92454356  DT.40123474  DT.100037018  DT.100880286  DT.121035937  DT.121035941 
    DT.121035949  DT.121035913  DT.121035953  DT.92454352  DT.92454361  DT.95257212  DT.121035975  DT.448831 

    24/439 AceView cDNA sequences (see all 439):

    NM_005687 BQ437945 CR605981 BX951165 CR619824 CB159488 BX378040 BI259238 
    BP371776 BQ923444 AL535056 BX444488 BX096340 BQ438273 BC006502 CB155099 
    BM798591 BM699108 BX438623 CR596774 BI870599 N52682 CR614902 AL533492 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FARSB    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:              -     -     -                                                                                                   
    SP2:                                                                                -                                             
    SP3:              -                                                                                                               
    SP4:                                                                                                                              


    ECgene alternative splicing isoforms for FARSB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FARSB expression in normal human tissues (normalized intensities)      FARSB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTGCTCCT
    FARSB Expression
    About this image


    FARSB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Cerebral Cortex
             ganglion/cranial/vagus X   
     
     Nose (Sensory Organs)    fully expand to see all 3 entries
             sensory organ/nose/nasal cavity   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Eye (Sensory Organs)
             Retina
     
     Thymus (Hematopoietic System)
             Thymus

    See FARSB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FARSB

    SOURCE GeneReport for Unigene cluster: Hs.471452
        SABiosciences Custom PCR Arrays for FARSB
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FARSB gene from 10/28 species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Farsb1 , 5 phenylalanyl-tRNA synthetase, beta subunit1, 5 87.27(n)1
    93.55(a)1
      1 (40.44 cM)5
    238741  NM_011811.31  NP_035941.21 
     784248365 
    chicken
    (Gallus gallus)
    Aves FARSB1 phenylalanyl-tRNA synthetase, beta subunit 78.12(n)
    82.31(a)
      424812  NM_001006543.1  NP_001006543.1 
    lizard
    (Anolis carolinensis)
    Reptilia FARSB6
    Uncharacterized protein
    80(a)
    1 ↔ 1
    3(25517832-25559251)
    African clawed frog
    (Xenopus laevis)
    Amphibia frsb-prov2 phenylalanyl-tRNA synthetase beta-subunit 76.8(n)    BC056121.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BQ479687.12   -- 73.87(n)    BQ479687.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG57061 CG5706 60.52(n)
    62.97(a)
      42888  NM_142980.3  NP_651237.1 
    worm
    (Caenorhabditis elegans)
    Secernentea fars-31 Protein FARS-3 59.98(n)
    59.69(a)
      174351  NM_063384.5  NP_495785.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FRS1(YLR060W)4
    FRS11
    Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, more4
    Frs1p1
    54.09(n)1
    48.17(a)1
      12(260979-262766)4
    8507491, 4  NP_013161.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G725501 phenylalanyl-tRNA synthetase beta chain 57.66(n)
    50.6(a)
      843587  NM_105914.4  NP_177399.1 
    rice
    (Oryza sativa)
    Liliopsida Os.51322 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 77.61(n)    AK101679.1 


    ENSEMBL Gene Tree for FARSB (if available)
    TreeFam Gene Tree for FARSB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FARSB gene
    LRRC472  
    1 SIMAP similar gene for FARSB using alignment to 3 protein entries:     SYFB_HUMAN (see all proteins):
    FARSLB

    FARSB for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FARSB
    PGOHUM00000258496


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1544 SNPs in FARSB are shown (see all 1544)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1418197231,2
    --223435749(+) AAAAGA/GGAGGT 1 -- ds50010--------
    rs1881815021,2
    --223435754(+) AGAGGC/TCTAAT 1 -- ds50010--------
    rs1506261581,2
    --223435976(+) TCACAC/GATAGA 1 -- ds50010--------
    rs1386412141,2
    --223436054(+) ACTGAC/TCTCAG 1 -- ds50010--------
    rs1118883581,2
    C--223436184(+) ATCTCGAACT   
       CAT
    /-
    GAACT
    1 -- ut311Minor allele frequency- -:0.50CSA 2
    rs584123431,2
    C--223436185(+) TCTCG-/AACTCAT
    G
    /GAACTCAT
    AACTC
    2 -- ut311NA 2
    rs1493307361,2
    C--223436269(+) AATCCA/GTTCCA 1 -- ut310--------
    rs37689721,2
    C,H--223436358(+) CTCCAC/TGGGGC 1 -- ut31 ese34Minor allele frequency- T:0.00NS EA 420
    rs37689731,2
    C,F,A,H--223436402(+) CCACAC/TTGGTA 1 -- ut31 ese322Minor allele frequency- T:0.46EA NA NS WA CSA 2240
    rs32110181,2
    C,F,O,A,H--223436428(-) TGCATA/GTTAGG 1 -- ut31 ese322Minor allele frequency- N:0.00EA MN NA NS CSA WA 2828

    HapMap Linkage Disequilibrium report for FARSB (223435255 - 223521056 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for FARSB:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1232411CNV Deletion17803354
    esv2377277CNV Deletion18987734
    esv2585241CNV Deletion19546169
    esv2721518CNV Deletion23290073
    esv3729CNV Deletion18987735
    esv2721519CNV Deletion23290073
    esv1000228CNV Deletion20482838
    dgv20e197CNV Deletion19546169
    esv5526CNV Loss19470904
    nsv834551CNV Gain+Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609690    OMIM disorders: --

    3 diseases for FARSB:    About MalaCards
    chronic myeloid leukemia    myeloid leukemia    leukemia


    FARSB for disorders           About GeneDecksing

    Genetic Association Database (GAD): FARSB
    Human Genome Epidemiology (HuGE) Navigator: FARSB (1 document)

    Export disorders for FARSB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FARSB gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with FARSB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human phenylalanyl-tRNA synthetase: cloning, characterization of the deduced amino acid sequences in terms of the structural domains and coordinately regulated expression of the alpha and beta subunits in chronic myeloid leukemia cells. (PubMed id 10049785)1, 2, 3, 9 Rodova M.... Safro M.G. (1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
    5. Cloning and expression of human phenylalanyl-tRNA synthetase in Escherichia coli: comparative study of purified recombinant enzymes. (PubMed id 11858721)1, 9 Moor N....Safro M. (2002)
    6. Role of low-molecular-weight substrates in functional binding of the tRNAPhe acceptor end by phenylalanyl-tRNA synthetase. (PubMed id 15000680)1, 9 Vasil'eva I.A....Moor N.A. (2004)
    7. A series of spirocyclic analogues as potent inhibitors of bacterial phenylalanyl-tRNA synthetases. (PubMed id 14980694)1, 9 Yu X.Y....Oliver N. (2004)
    8. Structural basis for discrimination of L-phenylalanine from L-tyrosine by phenylalanyl-tRNA synthetase. (PubMed id 16338408)7, 9 Kotik-Kogan O....Safro M. (2005)
    9. Cloning of the cDNA encoding phenylalanyl tRNA synthetase regulatory alpha-subunit-like protein whose expression is down-regulated during differentiation. (PubMed id 10375616)1, 9 Zhou X....Marks P.A. (1999)
    10. Crystal structure of human mitochondrial PheRS complex ed with tRNA(Phe) in the active 'open' state. (PubMed id 22137894)1 Klipcan L....Safro M.G. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10056 HGNC: 17800 AceView: FARSLB Ensembl:ENSG00000116120 euGenes: HUgn10056
    ECgene: FARSB Kegg: 10056 H-InvDB: FARSB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FARSB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FARSB gene:
    Search GeneIP for patents involving FARSB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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