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Aliases for FARSB Gene

Aliases for FARSB Gene

  • Phenylalanyl-TRNA Synthetase, Beta Subunit 2 3
  • FARSLB 3 4 6
  • FRSB 3 4 6
  • Phenylalanyl-TRNA Synthetase-Like, Beta Subunit 2 3
  • EC 6.1.1.20 4 64
  • PheRS 3 4
  • Phenylalanine-TRNA Synthetase-Like, Beta Subunit 3
  • Phenylalanine TRNA Ligase 1, Beta, Cytoplasmic 3
  • Phenylalanyl-TRNA Synthetase Beta-Subunit 3
  • Phenylalanyl-TRNA Synthetase Beta Subunit 4
  • Phenylalanine--TRNA Ligase Beta Subunit 3
  • Phenylalanyl-TRNA Synthetase Beta Chain 3
  • Phenylalanine--TRNA Ligase Beta Chain 3
  • Phenylalanine-TRNA Ligase Beta Chain 3
  • Phenylalanine TRNA Ligase 1 2
  • Cytoplasmic 2
  • EC 6.1.1 64
  • HSPC173 3
  • PheHB 3
  • Beta 2

External Ids for FARSB Gene

Previous Symbols for FARSB Gene

  • FARSLB

Summaries for FARSB Gene

Entrez Gene Summary for FARSB Gene

  • This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for FARSB Gene

FARSB (Phenylalanyl-TRNA Synthetase, Beta Subunit) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include RNA binding and phenylalanine-tRNA ligase activity. An important paralog of this gene is LRRC47.

Gene Wiki entry for FARSB Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FARSB Gene

Genomics for FARSB Gene

Genomic Location for FARSB Gene

Start:
222,570,536 bp from pter
End:
222,656,337 bp from pter
Size:
85,802 bases
Orientation:
Minus strand

Genomic View for FARSB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FARSB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FARSB Gene

Regulatory Elements for FARSB Gene

Proteins for FARSB Gene

  • Protein details for FARSB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSD9-SYFB_HUMAN
    Recommended name:
    Phenylalanine--tRNA ligase beta subunit
    Protein Accession:
    Q9NSD9
    Secondary Accessions:
    • B4DFM0
    • O95708
    • Q4ZFX1
    • Q57ZJ5
    • Q9NZZ6

    Protein attributes for FARSB Gene

    Size:
    589 amino acids
    Molecular mass:
    66116 Da
    Quaternary structure:
    • Tetramer of two alpha and two beta subunits.

    Three dimensional structures from OCA and Proteopedia for FARSB Gene

    Alternative splice isoforms for FARSB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FARSB Gene

Proteomics data for FARSB Gene at MOPED

Selected DME Specific Peptides for FARSB Gene

Post-translational modifications for FARSB Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys64, Lys329, and Lys560

Other Protein References for FARSB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for FARSB Gene

Gene Families for FARSB Gene

HGNC:
  • aaRS2 :Aminoacyl tRNA synthetases / Class II

UniProtKB/Swiss-Prot:

SYFB_HUMAN
Domain:
  • Contains 1 B5 domain.:
    • Q9NSD9
Family:
  • Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.:
    • Q9NSD9
genes like me logo Genes that share domains with FARSB: view

Function for FARSB Gene

Molecular function for FARSB Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)

Enzyme Numbers (IUBMB) for FARSB Gene

Gene Ontology (GO) - Molecular Function for FARSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0000287 magnesium ion binding IEA --
GO:0003723 RNA binding IEA --
GO:0004826 phenylalanine-tRNA ligase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with FARSB: view

Phenotypes for FARSB Gene

GenomeRNAi human phenotypes for FARSB:
genes like me logo Genes that share phenotypes with FARSB: view

miRNA for FARSB Gene

miRTarBase miRNAs that target FARSB

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for FARSB Gene

Localization for FARSB Gene

Subcellular locations from UniProtKB/Swiss-Prot for FARSB Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FARSB Gene COMPARTMENTS Subcellular localization image for FARSB gene
Compartment Confidence
cytosol 4
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for FARSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 10049785
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with FARSB: view

Pathways for FARSB Gene

genes like me logo Genes that share pathways with FARSB: view

Pathways by source for FARSB Gene

1 KEGG pathway for FARSB Gene

Gene Ontology (GO) - Biological Process for FARSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS 10049785
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006432 phenylalanyl-tRNA aminoacylation IEA --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with FARSB: view

Compounds for FARSB Gene

(5) HMDB Compounds for FARSB Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
L-Phenylalanine
  • (-)-beta-Phenylalanine
63-91-2
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8

(1) Drugbank Compounds for FARSB Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Phenylalanine
  • (S)-alpha-Amino-beta-phenylpropionic acid
63-91-2 target

(5) Novoseek inferred chemical compound relationships for FARSB Gene

Compound -log(P) Hits PubMed IDs
trna(phe) 91.9 6
anticodon 80 1
phenylalanine 71.8 3
trna 68 6
atp 37.6 3
genes like me logo Genes that share compounds with FARSB: view

Transcripts for FARSB Gene

Unigene Clusters for FARSB Gene

Phenylalanyl-tRNA synthetase, beta subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FARSB Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for FARSB Gene

GeneLoc Exon Structure for
FARSB
ECgene alternative splicing isoforms for
FARSB

Expression for FARSB Gene

mRNA expression in normal human tissues for FARSB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FARSB Gene

SOURCE GeneReport for Unigene cluster for FARSB Gene Hs.471452

genes like me logo Genes that share expressions with FARSB: view

Orthologs for FARSB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FARSB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FARSB 36
  • 99.6 (n)
  • 99.49 (a)
FARSB 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FARSB 36
  • 90.21 (n)
  • 93.89 (a)
FARSB 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 75 (a)
OneToMany
-- 37
  • 95 (a)
OneToMany
FARSB 36
  • 92.64 (n)
  • 95.08 (a)
mouse
(Mus musculus)
Mammalia Farsb 36
  • 87.27 (n)
  • 93.55 (a)
Farsb 16
Farsb 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FARSB 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 83 (a)
OneToMany
-- 37
  • 84 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Farsb 36
  • 87.72 (n)
  • 93.38 (a)
chicken
(Gallus gallus)
Aves FARSB 36
  • 78.12 (n)
  • 82.31 (a)
FARSB 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FARSB 37
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia frsb-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia farsb 36
  • 72.23 (n)
  • 79.22 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9004 36
zebrafish
(Danio rerio)
Actinopterygii farsb 36
  • 69.9 (n)
  • 76.19 (a)
farsb 37
  • 76 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003517 36
  • 59.73 (n)
  • 62.63 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5706 36
  • 60.52 (n)
  • 62.97 (a)
CG5706 37
  • 62 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea fars-3 36
  • 59.98 (n)
  • 59.69 (a)
fars-3 37
  • 58 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR219W 36
  • 53.39 (n)
  • 48.35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FRS1 36
  • 54.2 (n)
  • 48.35 (a)
FRS1 37
  • 46 (a)
OneToMany
FRS1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D05137g 36
  • 54.67 (n)
  • 50.26 (a)
soybean
(Glycine max)
eudicotyledons Gma.2819 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G72550 36
  • 57.95 (n)
  • 50.94 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.8880 36
corn
(Zea mays)
Liliopsida Zm.12166 36
rice
(Oryza sativa)
Liliopsida Os.5132 36
Os05g0558900 36
  • 55.44 (n)
  • 51.53 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08888 36
  • 52.27 (n)
  • 49.4 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes frs1 36
  • 53.57 (n)
  • 48.42 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1025 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2834 37
  • 57 (a)
OneToOne
Species with no ortholog for FARSB:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FARSB Gene

ENSEMBL:
Gene Tree for FARSB (if available)
TreeFam:
Gene Tree for FARSB (if available)

Paralogs for FARSB Gene

Paralogs for FARSB Gene

Selected SIMAP similar genes for FARSB Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for FARSB Gene

genes like me logo Genes that share paralogs with FARSB: view

Variants for FARSB Gene

Sequence variations from dbSNP and Humsavar for FARSB Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs7185 -- 222,571,888(+) TCCAA(C/T)ATTGA missense, reference
rs868206 -- 222,650,907(+) ACCAG(A/G)GTAAT intron-variant
rs868207 -- 222,651,084(+) AACCT(C/T)AAGAA intron-variant
rs868392 -- 222,652,540(-) CCCCA(A/G)ATGGA intron-variant
rs874363 -- 222,609,911(+) AAGAC(A/G)TGCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FARSB Gene

Variant ID Type Subtype PubMed ID
nsv834551 CNV Gain+Loss 17160897
esv2585241 CNV Deletion 19546169
esv2721518 CNV Deletion 23290073
esv2377277 CNV Deletion 18987734
esv3729 CNV Deletion 18987735
esv2721519 CNV Deletion 23290073
dgv20e197 CNV Deletion 19546169
esv1000228 CNV Deletion 20482838
esv1232411 CNV Deletion 17803354
esv5526 CNV Loss 19470904

Relevant External Links for FARSB Gene

HapMap Linkage Disequilibrium report
FARSB

Disorders for FARSB Gene

Relevant External Links for FARSB

Genetic Association Database (GAD)
FARSB
Human Genome Epidemiology (HuGE) Navigator
FARSB
genes like me logo Genes that share disorders with FARSB: view

No data available for UniProtKB/Swiss-Prot for FARSB Gene

Publications for FARSB Gene

  1. Human phenylalanyl-tRNA synthetase: cloning, characterization of the deduced amino acid sequences in terms of the structural domains and coordinately regulated expression of the alpha and beta subunits in chronic myeloid leukemia cells. (PMID: 10049785) Rodova M. … Safro M.G. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23
  2. Cloning of the cDNA encoding phenylalanyl tRNA synthetase regulatory alpha-subunit-like protein whose expression is down-regulated during differentiation. (PMID: 10375616) Zhou X. … Marks P.A. (Gene 1999) 3 23
  3. Cloning and expression of human phenylalanyl-tRNA synthetase in Escherichia coli: comparative study of purified recombinant enzymes. (PMID: 11858721) Moor N. … Safro M. (Protein Expr. Purif. 2002) 3 23
  4. A series of spirocyclic analogues as potent inhibitors of bacterial phenylalanyl-tRNA synthetases. (PMID: 14980694) Yu X.Y. … Oliver N. (Bioorg. Med. Chem. Lett. 2004) 3 23
  5. Role of low-molecular-weight substrates in functional binding of the tRNAPhe acceptor end by phenylalanyl-tRNA synthetase. (PMID: 15000680) Vasil'eva I.A. … Moor N.A. (Biochemistry Mosc. 2004) 3 23

Products for FARSB Gene

Sources for FARSB Gene

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