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Aliases for FARSB Gene

Aliases for FARSB Gene

  • Phenylalanyl-TRNA Synthetase Beta Subunit 2 3 4 5
  • Phenylalanyl-TRNA Synthetase-Like, Beta Subunit 2 3
  • Phenylalanine TRNA Ligase 1, Beta, Cytoplasmic 2 3
  • EC 6.1.1.20 4 61
  • FARSLB 3 4
  • PheRS 3 4
  • FRSB 3 4
  • Phenylalanine-TRNA Synthetase-Like, Beta Subunit 3
  • Phenylalanyl-TRNA Synthetase, Beta Subunit 2
  • Phenylalanine--TRNA Ligase Beta Subunit 3
  • Phenylalanyl-TRNA Synthetase Beta Chain 3
  • Phenylalanine-TRNA Ligase Beta Chain 3
  • EC 6.1.1 61
  • HSPC173 3
  • PheHB 3

External Ids for FARSB Gene

Previous HGNC Symbols for FARSB Gene

  • FARSLB

Previous GeneCards Identifiers for FARSB Gene

  • GC02M223144
  • GC02M223435
  • GC02M215289

Summaries for FARSB Gene

Entrez Gene Summary for FARSB Gene

  • This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for FARSB Gene

FARSB (Phenylalanyl-TRNA Synthetase Beta Subunit) is a Protein Coding gene. Among its related pathways are tRNA Aminoacylation and Gene Expression. GO annotations related to this gene include RNA binding and magnesium ion binding. An important paralog of this gene is LRRC47.

Gene Wiki entry for FARSB Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FARSB Gene

Genomics for FARSB Gene

Regulatory Elements for FARSB Gene

Enhancers for FARSB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F222707 1.3 Ensembl ENCODE 10.6 -52.4 -52357 3.4 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 ACSL3 MOGAT1 LOC105373904 FARSB RPL31P17 ENSG00000203531
GH02F222690 1.2 Ensembl ENCODE 11.4 -34.4 -34446 0.4 MLX SIN3A ARID4B ZNF2 ELK1 ZNF143 MXD4 MIER2 REST PPARG FARSB ACSL3 LOC105373904 ENSG00000203531 GC02M222677 LOC100384885
GH02F222903 0.8 ENCODE 11.1 -248.4 -248366 2.2 SOX13 CTCF SAP130 ARID4B ZSCAN9 RAD21 YY1 POLR2A ZNF143 SMC3 ACSL3 FARSB GC02M222904 GC02M222847
GH02F222304 0.7 Ensembl 10.8 +351.0 350955 2.4 RFX1 RNF2 SUZ12 CBX2 BMI1 CBX8 HDAC2 MBD1 CTBP2 KDM1A FARSB CCDC140 LOC440934
GH02F222689 0.4 Ensembl 17.3 -33.1 -33146 0.2 ATF3 MNT FARSB ACSL3 LOC105373904 ENSG00000203531 GC02M222677 LOC100384885
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FARSB on UCSC Golden Path with GeneCards custom track

Promoters for FARSB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000018945 355 3200 HDGF PKNOX1 ATF1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48

Genomic Location for FARSB Gene

Chromosome:
2
Start:
222,570,536 bp from pter
End:
222,656,355 bp from pter
Size:
85,820 bases
Orientation:
Minus strand

Genomic View for FARSB Gene

Genes around FARSB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FARSB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FARSB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FARSB Gene

Proteins for FARSB Gene

  • Protein details for FARSB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSD9-SYFB_HUMAN
    Recommended name:
    Phenylalanine--tRNA ligase beta subunit
    Protein Accession:
    Q9NSD9
    Secondary Accessions:
    • B4DFM0
    • O95708
    • Q4ZFX1
    • Q57ZJ5
    • Q9NZZ6

    Protein attributes for FARSB Gene

    Size:
    589 amino acids
    Molecular mass:
    66116 Da
    Quaternary structure:
    • Heterotetramer; dimer of two heterodimers formed by FARSA and FARSB.

    Three dimensional structures from OCA and Proteopedia for FARSB Gene

    Alternative splice isoforms for FARSB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FARSB Gene

Selected DME Specific Peptides for FARSB Gene

Q9NSD9:
  • IKFKPLN
  • GLELDEITSEK
  • AGFTEALTF
  • EDAAIAYGY
  • VKRDLLF
  • EKLHQNI
  • QFPLNKLTE
  • LVAIGTHD
  • SMPPIIN

Post-translational modifications for FARSB Gene

  • Ubiquitination at Lys 64, Lys 329, and Lys 560
  • Modification sites at PhosphoSitePlus

Other Protein References for FARSB Gene

Domains & Families for FARSB Gene

Gene Families for FARSB Gene

Graphical View of Domain Structure for InterPro Entry

Q9NSD9

UniProtKB/Swiss-Prot:

SYFB_HUMAN :
  • Contains 1 B5 domain.
  • Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
Domain:
  • Contains 1 B5 domain.
Family:
  • Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
genes like me logo Genes that share domains with FARSB: view

Function for FARSB Gene

Molecular function for FARSB Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).

Enzyme Numbers (IUBMB) for FARSB Gene

Gene Ontology (GO) - Molecular Function for FARSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0003723 RNA binding IEA --
GO:0004812 aminoacyl-tRNA ligase activity IEA --
GO:0004826 phenylalanine-tRNA ligase activity IDA,TAS 20223217
GO:0005515 protein binding IPI 20223217
genes like me logo Genes that share ontologies with FARSB: view
genes like me logo Genes that share phenotypes with FARSB: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FARSB Gene

Localization for FARSB Gene

Subcellular locations from UniProtKB/Swiss-Prot for FARSB Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FARSB gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FARSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 10049785
GO:0005829 cytosol TAS --
GO:0009328 phenylalanine-tRNA ligase complex IDA 20223217
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with FARSB: view

Pathways & Interactions for FARSB Gene

genes like me logo Genes that share pathways with FARSB: view

Pathways by source for FARSB Gene

1 KEGG pathway for FARSB Gene

Gene Ontology (GO) - Biological Process for FARSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS 10049785
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006432 phenylalanyl-tRNA aminoacylation IDA 20223217
GO:0051290 protein heterotetramerization IDA 20223217
genes like me logo Genes that share ontologies with FARSB: view

No data available for SIGNOR curated interactions for FARSB Gene

Drugs & Compounds for FARSB Gene

(6) Drugs for FARSB Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Phenylalanine Approved Nutra Target 0
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(4) Additional Compounds for FARSB Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with FARSB: view

Transcripts for FARSB Gene

mRNA/cDNA for FARSB Gene

Unigene Clusters for FARSB Gene

Phenylalanyl-tRNA synthetase, beta subunit:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FARSB Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for FARSB Gene

GeneLoc Exon Structure for
FARSB
ECgene alternative splicing isoforms for
FARSB

Expression for FARSB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FARSB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FARSB Gene

This gene is overexpressed in Breast (7.1) and Peripheral blood mononuclear cells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FARSB Gene



Protein tissue co-expression partners for FARSB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FARSB Gene:

FARSB

SOURCE GeneReport for Unigene cluster for FARSB Gene:

Hs.471452
genes like me logo Genes that share expression patterns with FARSB: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FARSB Gene

Orthologs for FARSB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FARSB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FARSB 34 35
  • 99.6 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 95 (a)
OneToMany
FARSB 34
  • 92.64 (n)
-- 35
  • 75 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FARSB 34 35
  • 90.21 (n)
rat
(Rattus norvegicus)
Mammalia Farsb 34
  • 87.72 (n)
mouse
(Mus musculus)
Mammalia Farsb 34 16 35
  • 87.27 (n)
oppossum
(Monodelphis domestica)
Mammalia FARSB 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 84 (a)
OneToMany
-- 35
  • 83 (a)
OneToMany
chicken
(Gallus gallus)
Aves FARSB 34 35
  • 78.12 (n)
lizard
(Anolis carolinensis)
Reptilia FARSB 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia farsb 34
  • 72.23 (n)
African clawed frog
(Xenopus laevis)
Amphibia frsb-prov 34
zebrafish
(Danio rerio)
Actinopterygii farsb 34 35
  • 69.9 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9004 34
fruit fly
(Drosophila melanogaster)
Insecta CG5706 34 35
  • 60.52 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003517 34
  • 59.73 (n)
worm
(Caenorhabditis elegans)
Secernentea fars-3 34 35
  • 59.98 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D05137g 34
  • 54.67 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FRS1 34 35 37
  • 54.2 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR219W 34
  • 53.39 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G72550 34
  • 57.95 (n)
soybean
(Glycine max)
eudicotyledons Gma.2819 34
rice
(Oryza sativa)
Liliopsida Os05g0558900 34
  • 55.44 (n)
Os.5132 34
barley
(Hordeum vulgare)
Liliopsida Hv.8880 34
corn
(Zea mays)
Liliopsida Zm.12166 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2834 35
  • 57 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes frs1 34
  • 53.57 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08888 34
  • 52.27 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1025 34
Species where no ortholog for FARSB was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FARSB Gene

ENSEMBL:
Gene Tree for FARSB (if available)
TreeFam:
Gene Tree for FARSB (if available)

Paralogs for FARSB Gene

Paralogs for FARSB Gene

(1) SIMAP similar genes for FARSB Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for FARSB Gene

genes like me logo Genes that share paralogs with FARSB: view

Variants for FARSB Gene

Sequence variations from dbSNP and Humsavar for FARSB Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10170846 -- 222,652,986(+) GATTA(C/G)TAATT intron-variant
rs10183146 -- 222,631,932(+) CCAGG(C/T)GTGGT intron-variant
rs10183649 -- 222,632,432(+) GGGGC(C/T)CATGT intron-variant
rs10190787 -- 222,634,774(+) CAAAA(A/C)TACCT intron-variant
rs10194152 -- 222,594,987(+) TATTG(C/T)TTTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FARSB Gene

Variant ID Type Subtype PubMed ID
nsv963776 CNV duplication 23825009
nsv955033 CNV deletion 24416366
nsv834551 CNV gain+loss 17160897
nsv1145735 CNV deletion 26484159
nsv1072071 CNV deletion 25765185
esv5526 CNV loss 19470904
esv3729 CNV loss 18987735
esv3594426 CNV loss 21293372
esv3561050 CNV deletion 23714750
esv2721519 CNV deletion 23290073
esv2721518 CNV deletion 23290073
esv2585241 CNV deletion 19546169
esv2377277 CNV deletion 18987734
esv1232411 CNV deletion 17803354
esv1000228 CNV deletion 20482838
dgv2155n106 CNV deletion 24896259
dgv20e197 CNV deletion 19546169

Variation tolerance for FARSB Gene

Residual Variation Intolerance Score: 27.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FARSB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FARSB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FARSB Gene

Disorders for FARSB Gene

Relevant External Links for FARSB

Genetic Association Database (GAD)
FARSB
Human Genome Epidemiology (HuGE) Navigator
FARSB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FARSB

No disorders were found for FARSB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FARSB Gene

Publications for FARSB Gene

  1. Human phenylalanyl-tRNA synthetase: cloning, characterization of the deduced amino acid sequences in terms of the structural domains and coordinately regulated expression of the alpha and beta subunits in chronic myeloid leukemia cells. (PMID: 10049785) Rodova M. … Safro M.G. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 22 64
  2. Structure of human cytosolic phenylalanyl-tRNA synthetase: evidence for kingdom-specific design of the active sites and tRNA binding patterns. (PMID: 20223217) Finarov I. … Safro M.G. (Structure 2010) 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Structural basis for discrimination of L-phenylalanine from L-tyrosine by phenylalanyl-tRNA synthetase. (PMID: 16338408) Kotik-Kogan O. … Safro M. (Structure 2005) 22 25 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for FARSB Gene

Sources for FARSB Gene

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