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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FARSB Gene

protein-coding   GIFtS: 60
GCID: GC02M223435

phenylalanyl-tRNA synthetase, beta subunit

(Previous names: phenylalanyl-tRNA synthetase-like, beta subunit )
(Previous symbol: FARSLB)
 Explore 4 diseases affiliated with
FARSB via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FARSB    

Aliases
for FARSB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Phenylalanyl-TRNA Synthetase, Beta Subunit1 2     Phenylalanine--TRNA Ligase Beta Chain2
FARSLB1 2 3 5     Phenylalanine--TRNA Ligase Beta Subunit2
FRSB1 2 3 5     Phenylalanine-TRNA Ligase Beta Chain2
PheHB1 2     Phenylalanine-TRNA Synthetase-Like, Beta Subunit2
Phenylalanyl-TRNA Synthetase-Like, Beta Subunit1 2     Phenylalanyl-TRNA Synthetase Beta Chain2
PheRS2 3     Phenylalanyl-TRNA Synthetase Beta-Subunit2
EC 6.1.1.203 8     Phenylalanyl-TRNA Synthetase Beta Subunit3
Phenylalanine TRNA Ligase 1, Beta, Cytoplasmic2     EC 6.1.18

External Ids:    HGNC: 178001   Entrez Gene: 100562   Ensembl: ENSG000001161207   OMIM: 6096905   UniProtKB: Q9NSD93   

Export aliases for FARSB gene to outside databases

Previous GC identifers: GC02M223144 GC02M215289


Summaries
for FARSB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FARSB:
This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This
enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence
of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA.
A pseudogene located on chromosome 10 has been identified. (provided by RefSeq, Jul 2008)

Gene Wiki entry for FARSB


Genomic Views
for FARSB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FARSB gene promoter:
         NF-1   NF-1/L   LUN-1   GATA-1   POU2F1   HOXA5   FOXJ2 (long isoform)   POU2F1a   FOXJ2   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FARSB promoter sequence
   Search SABiosciences Chromatin IP Primers for FARSB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FARSB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.1   Ensembl cytogenetic band:  2q36.1   HGNC cytogenetic band: 2q36.2

FARSB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FARSB gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M223435:  view genomic region     (about GC identifiers)

Start:
 223,435,255 bp from pter      End:
 223,521,056 bp from pter
Size:
 85,802 bases      Orientation:
 minus strand

Proteins
for FARSB gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SYFB_HUMAN, Q9NSD9 (See protein sequence)
Recommended Name: Phenylalanine--tRNA ligase beta subunit  
Size: 589 amino acids; 66116 Da
Subunit: Tetramer of two alpha and two beta subunits (By similarity)
Subcellular location: Cytoplasm (By similarity)
1 PDB 3D structure from and Proteopedia for FARSB:
3L4G (3D)    
Secondary accessions: O95708 Q4ZFX1 Q57ZJ5 Q9NZZ6

Explore the universe of human proteins at neXtProt for FARSB: NX_Q9NSD9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NSD9

    • 4/9 DME Specific Peptides for FARSB (Q9NSD9) (see all 9)
     IKFKPLN  VKRDLLF  EKLHQNI  SMPPIIN 

    FARSB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005678.3  
    ENSEMBL proteins: 
     ENSP00000281828   ENSP00000442950  
    Reactome Protein details: Q9NSD9
    Human Recombinant Protein Products: 
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    Novus Biologicals FARSB Proteins
    Novus Biologicals FARSB Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005737cytoplasm TAS10049785
    GO:0005829cytosol TAS--


    FARSB for ontologies           About GeneDecksing



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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for FARSB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FARSB for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR009061 DNA-bd_dom_put
     IPR020825 Phe-tRNA_synthase_B3/B4
     IPR004531 Phe-tRNA-synth_IIc_bsu_arc
     IPR005146 B3/B4_tRNA-bd
     IPR005147 tRNA_synthase_B5-dom

    Graphical View of Domain Structure for InterPro Entry Q9NSD9

    ProtoNet protein and cluster: Q9NSD9

    1 Blocks protein family: IPB005147 tRNA synthetase B5 domain

    UniProtKB/Swiss-Prot: SYFB_HUMAN, Q9NSD9
    Similarity: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily
    Similarity: Contains 1 B5 domain


    Function
    for FARSB gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SYFB_HUMAN, Q9NSD9
    Catalytic activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)

    Enzyme Numbers (IUBMB): EC 6.1.1.201 2 EC 6.1.12

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FARSB
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate FARSB:
    hsa-miR-1197 hsa-miR-1324
    SwitchGear 3'UTR luciferase reporter plasmid: FARSB 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FARSB 

    Cell Line
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    Search LifeMap BioReagents cell lines for FARSB

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FARSB

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0003723RNA binding IEA--
    GO:0004826phenylalanine-tRNA ligase activity IEA--
    GO:0005524ATP binding IEA--


    FARSB for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for FARSB:
     Decreased Hepatitis C virus re 


    Pathways & Interactions
    for FARSB gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1tRNA Aminoacylation
    		tRNA Aminoacylation1.00
    		Aminoacyl-tRNA biosynthesis0.54
    		Cytosolic tRNA aminoacylation0.57
    2Generic Transcription Pathway
    		Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for FARSB
        Cytosolic tRNA aminoacylation
    tRNA Aminoacylation
    Gene Expression


    1         Kegg Pathway  (Kegg details for FARSB):
        Aminoacyl-tRNA biosynthesis


    FARSB for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FARSB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/30 Interacting proteins for FARSB (Q9NSD93 ENSP000002818284) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FARSAQ9Y2853, ENSP000003203094I2D: score=6 STRING: ENSP00000320309
    IARSP412523, ENSP000003647944I2D: score=3 STRING: ENSP00000364794
    FARS2O953633, ENSP000002746804I2D: score=2 STRING: ENSP00000274680
    UBA5Q9GZZ93, ENSP000003485654I2D: score=2 STRING: ENSP00000348565
    SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS10049785
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006432phenylalanyl-tRNA aminoacylation IEA--
    GO:0010467gene expression TAS--


    FARSB for ontologies           About GeneDecksing



    Drugs & Compounds
    for FARSB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FARSB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FARSB

    5 HMDB Compounds for FARSB    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Phenylalanine(-)-beta-Phenylalanine (see all 28)63-91-2--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for FARSB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Phenylalanine(S)-alpha-Amino-beta-phenylpropionic acid (see all 4)63-91-2target--16338408

    5 Novoseek chemical compound relationships for FARSB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trna(phe) 91.9 10 15000681 (2), 15000680 (2), 10049785 (1), 12354112 (1)
    anticodon 80 1 10329163 (1)
    phenylalanine 71.8 3 15000680 (2), 15000681 (1)
    trna 68 13 16866361 (4), 10049785 (1), 12354112 (1)
    atp 37.6 3 15000680 (2), 15000681 (1)

    Search CenterWatch for drugs/clinical trials and news about FARSB / SYFB 

    Transcripts
    for FARSB gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FARSB gene: 
    NM_005687.3  

    Unigene Cluster for FARSB:

    Phenylalanyl-tRNA synthetase, beta subunit
    Hs.471452  [show with all ESTs]
    Unigene Representative Sequence: D84430
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000281828(uc002vne.1 uc010zlq.1 uc002vnf.1 uc002vng.1)
    ENST00000536361

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FARSB
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate FARSB:
    hsa-miR-1197 hsa-miR-1324
    SwitchGear 3'UTR luciferase reporter plasmid: FARSB 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FARSB (see all 7)
    OriGene shRNA RFP: FARSB
    OriGene siRNA: FARSB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FARSB
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: FARSB (NM_005687)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FARSB

    Additional cDNA sequence: 

    AF042346.1 AF161521.1 AK001025.1 AK055289.1 AK291531.1 AK294158.1 AK316497.1 BC006502.2 
    BC008434.1 BC011261.1 BC017783.1 BC022273.1 D84430.1 

    24 DOTS entries:

    DT.456191  DT.101961732  DT.102829034  DT.121035964  DT.95257210  DT.448035  DT.95261256  DT.92454348 
    DT.455759  DT.92454343  DT.92454356  DT.40123474  DT.100037018  DT.100880286  DT.121035937  DT.121035941 
    DT.121035949  DT.121035913  DT.121035953  DT.92454352  DT.92454361  DT.95257212  DT.121035975  DT.448831 

    24/439 AceView cDNA sequences (see all 439):

    CR605981 BM472169 BC022273 CR608008 D84430 F07598 BU175447 BQ437945 
    AL119097 BX096340 BF765223 BQ923444 AK055289 BX951165 AA365905 BG109815 
    BQ428504 AA926949 BQ921822 BM967063 CB130550 N52682 BI870599 CR596774 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FARSB    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:              -     -     -                                                                                                   
    SP2:                                                                                -                                             
    SP3:              -                                                                                                               
    SP4:                                                                                                                              


    ECgene alternative splicing isoforms for FARSB

    Expression
    for FARSB gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FARSB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCTGCTCCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FARSB expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyUreteric BudUreteric Bud CellsKidney
    KidneyUreteric BudUreteric Bud Tip CellsKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See FARSB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FARSB

    SOURCE GeneReport for Unigene cluster: Hs.471452
        SABiosciences Custom PCR Arrays for FARSB
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    In Situ
    Assay Products:     
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    Orthologs
    for FARSB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FARSB gene from 9/39 species (see all 39)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FARSB1 phenylalanyl-tRNA synthetase, beta subunit 78.12(n)
    82.31(a)    		   424812  NM_001006543.1  NP_001006543.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FARSB6
    		 --
    		 82(a)
    		 1 ↔ 1
    		 3(25517865-25559251)
    African clawed frog
    (Xenopus laevis)    		 Amphibia frsb-prov2 phenylalanyl-tRNA synthetase beta-subunit 76.8(n)    BC056121.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BQ479687.12   -- 73.87(n)    BQ479687.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG57061 CG5706 60.52(n)
    62.97(a)    		   42888  NM_142980.3  NP_651237.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea fars-31 Protein FARS-3 59.98(n)
    59.69(a)    		   174351  NM_063384.5  NP_495785.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes FRS1(YLR060W)4
    FRS11    		 Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, more4
    Frs1p1    		 54.09(n)1
    48.17(a)1    		   12(260979-262766)4
    8507491, 4  NP_013161.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G725501 phenylalanyl-tRNA synthetase beta chain 57.66(n)
    50.6(a)    		   843587  NM_105914.4  NP_177399.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.51322 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 77.61(n)    AK101679.1 


    ENSEMBL Gene Tree for FARSB (if available)
    TreeFam Gene Tree for FARSB (if available) 

    Paralogs
    for FARSB gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FARSB gene
    LRRC472  
    1 SIMAP similar gene for FARSB using alignment to 3 protein entries:     SYFB_HUMAN (see all proteins):
    FARSLB

    FARSB for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FARSB
    PGOHUM00000258496


    Genomic Variants
    for FARSB gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1321 NCBI SNPs in FARSB are shown (see all 1321)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1418197231,2
    		--223435749(+) AAAAGA/GGAGGT 1 -- ds50010--------
    rs1881815021,2
    		--223435754(+) AGAGGC/TCTAAT 1 -- ds50010--------
    rs1506261581,2
    		--223435976(+) TCACAC/GATAGA 1 -- ds50010--------
    rs1386412141,2
    		--223436054(+) ACTGAC/TCTCAG 1 -- ds50010--------
    rs1118883581,2
    		C,--223436184(+) ATCTCGAACT   
       CAT    /-    GAACT     		1 -- ut311Minor allele frequency- -:0.50CSA 2
    rs584123431,2
    		C--223436193(+) TCATGAACTC   
       ATG    /-    CAACA     		1 -- ut311Minor allele frequency- -:0.50NA 2
    rs1493307361,2
    		--223436269(+) AATCCA/GTTCCA 1 -- ut310--------
    rs37689721,2
    		H--223436358(+) CTCCAC/TGGGGC 1 -- ut31 ese34Minor allele frequency- T:0.00NS EA 420
    rs37689731,2
    		C,F,A,H,--223436402(+) CCACAC/TTGGTA 1 -- ut31 ese322Minor allele frequency- T:0.46EA NA NS WA CSA 2240
    rs32110181,2
    		C,F,O,A,H,--223436428(-) TGCATA/GTTAGG 1 -- ut31 ese322Minor allele frequency- N:0.00EA MN NA NS CSA WA 2828

    HapMap Linkage Disequilibrium report for FARSB (223435255 - 223521056 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for FARSB
         7 Indels: 26571 40423 45950 61887 42001 40422 98145

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FARSB
    DNA2.0 Custom Variant and Variant Library Synthesis for FARSB

    Disorders / Diseases
    for FARSB gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FARSB for disorders           About GeneDecksing

    OMIM gene information: 609690    OMIM disorders: --

    4 diseases for FARSB:    About MalaCards
    chronic myeloid leukemia    myeloid leukemia    leukemia    malaria

    Human Genome Epidemiology (HuGE) Navigator: FARSB (1 document)

    Export disorders for FARSB gene to outside databases

    Publications
    for FARSB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FARSB gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with FARSB)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human phenylalanyl-tRNA synthetase: cloning, characterization of the deduced amino acid sequences in terms of the structural domains and coordinately regulated expression of the alpha and beta subunits in chronic myeloid leukemia cells. (PubMed id 10049785)1, 2, 3, 9 Rodova M.... Safro M.G. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
    4. Cloning and expression of human phenylalanyl-tRNA synthetase in Escherichia coli: comparative study of purified recombinant enzymes. (PubMed id 11858721)1, 9 Moor N....Safro M. (2002)
    5. Role of low-molecular-weight substrates in functional binding of the tRNAPhe acceptor end by phenylalanyl-tRNA synthetase. (PubMed id 15000680)1, 9 Vasil'eva I.A....Moor N.A. (2004)
    6. A series of spirocyclic analogues as potent inhibitors of bacterial phenylalanyl-tRNA synthetases. (PubMed id 14980694)1, 9 Yu X.Y....Oliver N. (2004)
    7. Structural basis for discrimination of L-phenylalanine from L-tyrosine by phenylalanyl-tRNA synthetase. (PubMed id 16338408)7, 9 Kotik-Kogan O....Safro M. (2005)
    8. Cloning of the cDNA encoding phenylalanyl tRNA synthetase regulatory alpha-subunit-like protein whose expression is down-regulated during differentiation. (PubMed id 10375616)1, 9 Zhou X....Marks P.A. (1999)
    9. Crystal structure of human mitochondrial PheRS complex ed with tRNA(Phe) in the active 'open' state. (PubMed id 22137894)1 Klipcan L....Safro M.G. (2012)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    External Searches for FARSB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FARSB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10056 HGNC: 17800 AceView: FARSLB Ensembl:ENSG00000116120 euGenes: HUgn10056
    ECgene: FARSB Kegg: 10056 H-InvDB: FARSB

    Other Databases showing FARSB gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FARSB gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FARSB Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FARSB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FARSB gene:
    Search GeneIP for patents involving FARSB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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