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FARSA Gene(Protein Coding)

Phenylalanyl-TRNA Synthetase Alpha Subunit

GCID:
GC19M012922
GIFtS:
55
Genes Participants
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Aliases for FARSA Gene

Aliases for FARSA Gene

  • Phenylalanyl-TRNA Synthetase Alpha Subunit 2 3 4 5
  • Phenylalanyl-TRNA Synthetase-Like, Alpha Subunit 2 3
  • Phenylalanine TRNA Ligase 1, Alpha, Cytoplasmic 2 3
  • EC 6.1.1.20 4 61
  • FARSLA 3 4
  • PheRS 3 4
  • FARSL 3 4
  • CML33 3 4
  • Phenylalanine-TRNA Synthetase-Like, Alpha Subunit 3
  • Phenylalanyl-TRNA Synthetase, Alpha Subunit 2
  • Phenylalanine-TRNA Synthetase Alpha-Subunit 3
  • Phenylalanine--TRNA Ligase Alpha Subunit 3
  • Phenylalanyl-TRNA Synthetase Alpha Chain 3
  • Phenylalanine--TRNA Ligase Alpha Chain 3
  • Phenylalanine-TRNA Synthetase-Like 2
  • PheHA 3
  • FRSA 3
  • FARS 4

External Ids for FARSA Gene

Previous HGNC Symbols for FARSA Gene

  • FARSL
  • FARSLA

Previous GeneCards Identifiers for FARSA Gene

  • GC19M012895
  • GC19M013033
  • GC19M012605

Summaries for FARSA Gene

Entrez Gene Summary for FARSA Gene

  • Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a product which is similar to the catalytic subunit of prokaryotic and Saccharomyces cerevisiae phenylalanyl-tRNA synthetases (PheRS). This gene product has been shown to be expressed in a tumor-selective and cell cycle stage- and differentiation-dependent manner, the first member of the tRNA synthetase gene family shown to exhibit this type of regulated expression [provided by RefSeq, Jul 2008]

GeneCards Summary for FARSA Gene

FARSA (Phenylalanyl-TRNA Synthetase Alpha Subunit) is a Protein Coding gene. Diseases associated with FARSA include Sarcocystosis and Parasitic Ectoparasitic Infectious Disease. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include poly(A) RNA binding and tRNA binding.

Gene Wiki entry for FARSA Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FARSA Gene

Genomics for FARSA Gene

Products:

  1. Regulatory Element

Regulatory Elements for FARSA Gene

Enhancers for FARSA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G013793 1.4 ENCODE dbSUPER 10.3 -861.8 -861811 5.5 HDGF FOXA2 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 LOC284454 C19orf53 MRI1 MIR23A MIR24-2 MIR27A FARSA ZSWIM4 ENSG00000267582
GH19G013115 1.8 FANTOM5 ENCODE dbSUPER 5.2 -184.9 -184899 7.7 CREB3L1 DMAP1 YBX1 YY1 ZNF143 SP3 NFYC TBX21 MEF2D ZNF610 CCDC130 WDR83OS ZNF791 ZNF564 ZNF44 ZNF136 MRI1 TRMT1 ZNF799 RFX1
GH19G012932 1.4 ENCODE dbSUPER 0.7 +0.5 549 2.3 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 CBX5 ZNF143 GCDH DNASE2 FARSA FARSA-AS1
GH19G012931 0.6 dbSUPER 0.7 +2.2 2197 0.6 CEBPG ZEB2 ZNF324 KLF16 ZNF692 PATZ1 SCRT2 ZNF600 ZBTB17 FARSA FARSA-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FARSA on UCSC Golden Path with GeneCards custom track

Promoters for FARSA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107331 537 1401 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 CBX5 ZNF143

Transcription factor binding sites by QIAGEN in the FARSA gene promoter:

Genomic Location for FARSA Gene

Chromosome:
19
Start:
12,922,470 bp from pter
End:
12,934,037 bp from pter
Size:
11,568 bases
Orientation:
Minus strand

Genomic View for FARSA Gene

Genes around FARSA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FARSA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FARSA Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FARSA Gene

Proteins for FARSA Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FARSA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y285-SYFA_HUMAN
    Recommended name:
    Phenylalanine--tRNA ligase alpha subunit
    Protein Accession:
    Q9Y285
    Secondary Accessions:
    • B4E363
    • Q9NSD8
    • Q9Y4W8

    Protein attributes for FARSA Gene

    Size:
    508 amino acids
    Molecular mass:
    57564 Da
    Quaternary structure:
    • Heterotetramer; dimer of two heterodimers formed by FARSA and FARSB.
    SequenceCaution:
    • Sequence=AAB51175.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FARSA Gene

    Alternative splice isoforms for FARSA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FARSA Gene

Protein Expression for FARSA Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for FARSA Gene

Q9Y285:
  • FWNFDAL
  • IFLEMGF
  • GGYGSQGYKY
  • KWVEVGNSG
  • THLAEFHQ
  • KNLLRTHTT
  • VIAWGLSLERPTMIKYGINNIR
  • MGFTEMP
  • IDRVFRNE
  • NIRELVGHKVNLQMVYDSP
  • YNPYTEPS
  • GSHEARVF
  • VGFSKAM

Post-translational modifications for FARSA Gene

  • Ubiquitination at Lys59, Lys101, isoforms=2106, isoforms=2150, isoforms=177, isoforms=187, isoforms=2208, isoforms=2311, isoforms=2315, Lys406, isoforms=2468, and Lys481
  • Modification sites at PhosphoSitePlus

Other Protein References for FARSA Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for FARSA Gene

Gene Families for FARSA Gene

HGNC:

Protein Domains for FARSA Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FARSA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y285

UniProtKB/Swiss-Prot:

SYFA_HUMAN :
  • Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
Family:
  • Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
genes like me logo Genes that share domains with FARSA: view

Function for FARSA Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for FARSA Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).

Enzyme Numbers (IUBMB) for FARSA Gene

Gene Ontology (GO) - Molecular Function for FARSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding IDA 22681889
GO:0004812 aminoacyl-tRNA ligase activity IEA --
GO:0004826 phenylalanine-tRNA ligase activity IDA,IEA 20223217
genes like me logo Genes that share ontologies with FARSA: view
genes like me logo Genes that share phenotypes with FARSA: view

Animal Models for FARSA Gene

MGI Knock Outs for FARSA:

Animal Model Products

  • Taconic Biosciences Mouse Models for FARSA

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FARSA Gene

Localization for FARSA Gene

Subcellular locations from UniProtKB/Swiss-Prot for FARSA Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FARSA gene
Compartment Confidence
cytosol 5
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FARSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS,IEA 9177188
GO:0005829 cytosol TAS --
GO:0009328 phenylalanine-tRNA ligase complex IDA 20223217
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with FARSA: view

Pathways & Interactions for FARSA Gene

genes like me logo Genes that share pathways with FARSA: view

Pathways by source for FARSA Gene

1 KEGG pathway for FARSA Gene

Gene Ontology (GO) - Biological Process for FARSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006432 phenylalanyl-tRNA aminoacylation IDA,IEA 20223217
GO:0043039 tRNA aminoacylation IEA --
GO:0051290 protein heterotetramerization IDA 20223217
genes like me logo Genes that share ontologies with FARSA: view

No data available for SIGNOR curated interactions for FARSA Gene

Drugs & Compounds for FARSA Gene

Products:

  1. Drug

(4) Drugs for FARSA Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Phenylalanine Approved Nutra Target 0
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for FARSA Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
 14000-31-8
genes like me logo Genes that share compounds with FARSA: view

Transcripts for FARSA Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for FARSA Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(488) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FARSA Gene

Phenylalanyl-tRNA synthetase, alpha subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FARSA Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2:
SP3:
SP4:

Relevant External Links for FARSA Gene

GeneLoc Exon Structure for
FARSA
ECgene alternative splicing isoforms for
FARSA

Expression for FARSA Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FARSA Gene

mRNA expression in normal human tissues for FARSA Gene
mRNA expression by BioGPS for FARSA GenemRNA expression by GTEx for FARSA Gene

Protein differential expression in normal tissues from HIPED for FARSA Gene

This gene is overexpressed in Lymph node (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FARSA Gene



Protein tissue co-expression partners for FARSA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FARSA Gene:

FARSA

SOURCE GeneReport for Unigene cluster for FARSA Gene:

Hs.23111

Evidence on tissue expression from TISSUES for FARSA Gene

  • Lung(4.5)
  • Nervous system(4.5)
  • Blood(4.4)
  • Intestine(2.9)
  • Skin(2.9)
  • Liver(2.4)
  • Stomach(2)
genes like me logo Genes that share expression patterns with FARSA: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FARSA Gene

Orthologs for FARSA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FARSA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FARSA 34 35
  • 99.67 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia FARSA 35
  • 90 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia FARSA 34 35
  • 89.96 (n)
cow
(Bos Taurus)
 Mammalia FARSA 34 35
  • 89.63 (n)
oppossum
(Monodelphis domestica)
 Mammalia FARSA 35
  • 86 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Farsa 34 16 35
  • 85.83 (n)
rat
(Rattus norvegicus)
 Mammalia Farsa 34
  • 85.5 (n)
chicken
(Gallus gallus)
 Aves FARSA 34 35
  • 75.95 (n)
lizard
(Anolis carolinensis)
 Reptilia FARSA 35
  • 67 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia farsa 34
  • 72.08 (n)
Str.3839 34
African clawed frog
(Xenopus laevis)
 Amphibia farsl-prov 34
zebrafish
(Danio rerio)
 Actinopterygii farsa 34 35
  • 74.04 (n)
wufj21a11 34
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.10382 34
fruit fly
(Drosophila melanogaster)
 Insecta CG2263 34 35
  • 66.33 (n)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP002653 34
  • 62.39 (n)
worm
(Caenorhabditis elegans)
 Secernentea fars-1 34 35
  • 58 (n)
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_AFR516W 34
  • 57.76 (n)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes FRS2 34 35 37
  • 52.04 (n)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0F25234g 34
  • 51.63 (n)
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT4G39280 34
  • 56.3 (n)
soybean
(Glycine max)
 eudicotyledons Gma.12602 34
rice
(Oryza sativa)
 Liliopsida Os10g0400800 34
  • 58.32 (n)
Os.3191 34
barley
(Hordeum vulgare)
 Liliopsida Hv.10634 34
wheat
(Triticum aestivum)
 Liliopsida Ta.1529 34
corn
(Zea mays)
 Liliopsida Zm.5623 34
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.1858 35
  • 63 (a)
 OneToOne
bread mold
(Neurospora crassa)
 Ascomycetes NCU05095 34
  • 60.47 (n)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes frs2 34
  • 50.51 (n)
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.11498 34
Species where no ortholog for FARSA was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for FARSA Gene

ENSEMBL:
Gene Tree for FARSA (if available)
TreeFam:
Gene Tree for FARSA (if available)

Paralogs for FARSA Gene

(1) SIMAP similar genes for FARSA Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with FARSA: view

No data available for Paralogs for FARSA Gene

Variants for FARSA Gene

Sequence variations from dbSNP and Humsavar for FARSA Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000185743 -- 12,927,963(+) TTTGC(A/G)GCGAG intron-variant
rs1000288063 -- 12,934,041(+) CTGCC(C/T)TTCTG upstream-variant-2KB
rs1000614335 -- 12,931,303(+) CTGTC(A/G)CTCAG intron-variant
rs1000662199 -- 12,927,765(+) GGTGC(G/T)GTGGC intron-variant
rs1000687918 -- 12,931,514(+) ACTCC(A/G)CCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FARSA Gene

Variant ID Type Subtype PubMed ID
nsv1160589 CNV duplication 26073780
nsv833754 CNV loss 17160897
nsv953977 CNV deletion 24416366

Variation tolerance for FARSA Gene

Residual Variation Intolerance Score: 24.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.69; 46.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FARSA Gene

Human Gene Mutation Database (HGMD)
FARSA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FARSA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FARSA Gene

Disorders for FARSA Gene

MalaCards: The human disease database

(7) MalaCards diseases for FARSA Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
sarcocystosis
  • sarcosporidiosis
parasitic ectoparasitic infectious disease
  • ectoparasitism
myiasis
  • infestation by fly larvae
theileriasis
  • infection by theileria
toxocariasis
  • infection by toxascaris
- elite association - COSMIC cancer census association via MalaCards
Search FARSA in MalaCards View complete list of genes associated with diseases

Relevant External Links for FARSA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FARSA
genes like me logo Genes that share disorders with FARSA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FARSA Gene

Publications for FARSA Gene

  1. Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent. (PMID: 9177188) Sen S. … White R.A. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 22 64
  2. Structure of human cytosolic phenylalanyl-tRNA synthetase: evidence for kingdom-specific design of the active sites and tRNA binding patterns. (PMID: 20223217) Finarov I. … Safro M.G. (Structure 2010) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for FARSA Gene

Sources for FARSA Gene

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