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FARSA Gene

protein-coding   GIFtS: 62
GCID: GC19M013033

Phenylalanyl-TRNA Synthetase, Alpha Subunit

(Previous names: phenylalanine-tRNA synthetase-like, phenylalanyl-tRNA synthetase-like,...)
(Previous symbols: FARSL, FARSLA)
  See FARSA-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phenylalanyl-TRNA Synthetase, Alpha Subunit1 2     PheHA2
FARSL1 2 3     pheRS2
FARSLA1 2 3     Phenylalanine TRNA Ligase 1, Alpha, Cytoplasmic2
Phenylalanyl-TRNA Synthetase-Like, Alpha Subunit1 2     Phenylalanine--TRNA Ligase Alpha Chain2
CML332 3     Phenylalanine--TRNA Ligase Alpha Subunit2
EC 6.1.1.203 8     Phenylalanine-TRNA Synthetase Alpha-Subunit2
alpha1     Phenylalanine-TRNA Synthetase-Like, Alpha Subunit2
cytoplasmic1     Phenylalanyl-TRNA Synthetase Alpha Chain2
Phenylalanine TRNA Ligase 11     FARS3
Phenylalanine-TRNA Synthetase-Like1     PheRS3
FRSA2     Phenylalanyl-TRNA Synthetase Alpha Subunit3

External Ids:    HGNC: 35921   Entrez Gene: 21932   Ensembl: ENSG000001791157   OMIM: 6029185   UniProtKB: Q9Y2853   

Export aliases for FARSA gene to outside databases

Previous GC identifers: GC19M012895 GC19M012605


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FARSA Gene:
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene
encodes a product which is similar to the catalytic subunit of prokaryotic and Saccharomyces cerevisiae
phenylalanyl-tRNA synthetases (PheRS). This gene product has been shown to be expressed in a tumor-selective and
cell cycle stage- and differentiation-dependent manner, the first member of the tRNA synthetase gene family shown
to exhibit this type of regulated expression (provided by RefSeq, Jul 2008)

GeneCards Summary for FARSA Gene:
FARSA (phenylalanyl-tRNA synthetase, alpha subunit) is a protein-coding gene. Diseases associated with FARSA include impetigo. GO annotations related to this gene include phenylalanine-tRNA ligase activity and tRNA binding.

Gene Wiki entry for FARSA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the FARSA gene promoter:
         p53   ATF-2   CUTL1   Nkx2-5   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFARSA promoter sequence
   Search Chromatin IP Primers for FARSA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FARSA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

FARSA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FARSA gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M013033:  view genomic region     (about GC identifiers)

Start:
13,033,284 bp from pter      End:
13,044,851 bp from pter
Size:
11,568 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SYFA_HUMAN, Q9Y285 (See protein sequence)
Recommended Name: Phenylalanine--tRNA ligase alpha subunit  
Size: 508 amino acids; 57564 Da
Subunit: Tetramer of two alpha and two beta subunits (By similarity)
Sequence caution: Sequence=AAB51175.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for FARSA:
3L4G (3D)    
Secondary accessions: Q9NSD8 Q9Y4W8

Explore the universe of human proteins at neXtProt for FARSA: NX_Q9Y285

Explore proteomics data for FARSA at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys59, Lys101, Lys106, Lys150, Lys177, Lys187, Lys208, Lys311, Lys315, Lys349,
                                 Lys406, Lys468, Lys481
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for FARSA (Q9Y285) (see all 13)
     VGFSKAM  FWNFDAL  MGFTEMP  IFLEMGF 


    See FARSA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004452.1  
    ENSEMBL proteins: 
     ENSP00000468051   ENSP00000396548   ENSP00000320309   ENSP00000468068   ENSP00000468384  
     ENSP00000467384   ENSP00000465402  
    Reactome Protein details: Q9Y285

    FARSA Human Recombinant Protein Products:

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    Novus Biologicals FARSA Proteins
    Novus Biologicals FARSA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for FARSA (95 products) 

     
    antibodies-online peptides for FARSA

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    antibodies-online antibodies for FARSA (28 products) 

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    Browse ELISAs at Cloud-Clone Corp.
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    antibodies-online kits for FARSA (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    aaRS2: Aminoacyl tRNA synthetases / Class II

    4 InterPro protein domains:
     IPR006195 aa-tRNA-synth_II
     IPR011991 WHTH_DNA-bd_dom
     IPR004529 Phe-tRNA-synth_IIc_asu
     IPR002319 Phenylalanyl-tRNA_Synthase

    Graphical View of Domain Structure for InterPro Entry Q9Y285

    ProtoNet protein and cluster: Q9Y285

    2 Blocks protein domains:
    IPB002319 Phenylalanyl-tRNA synthetase
    IPB013196 Helix-turn-helix


    UniProtKB/Swiss-Prot: SYFA_HUMAN, Q9Y285
    Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2
    subfamily


    Find genes that share domains with FARSA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYFA_HUMAN, Q9Y285
    Catalytic activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)

         Enzyme Number (IUBMB): EC 6.1.1.201 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000049tRNA binding IEA--
    GO:0000166nucleotide binding ----
    GO:0004812aminoacyl-tRNA ligase activity ----
    GO:0004826phenylalanine-tRNA ligase activity IEA--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with FARSA           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Farsa):
     growth/size/body  hematopoietic system  immune system  mortality/aging  skeleton 

    Find genes that share phenotypes with FARSA           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FARSA
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    miRNA
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    miRTarBase miRNAs that target FARSA:
    hsa-mir-484 (MIRT041766), hsa-let-7a-5p (MIRT052471), hsa-mir-503-5p (MIRT041106), hsa-mir-221-3p (MIRT046922)

    Block miRNA regulation of human, mouse, rat FARSA using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidFARSA 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: FARSA (NM_004461)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FARSA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FARSA

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FARSA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYFA_HUMAN, Q9Y285: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS9177188
    GO:0005829cytosol TAS--

    Find genes that share ontologies with FARSA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FARSA About    
    See pathways by source

    SuperPathContained pathways About
    1tRNA Aminoacylation
    tRNA Aminoacylation0.57
    Aminoacyl-tRNA biosynthesis0.52
    Cytosolic tRNA aminoacylation0.57
    2Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with FARSA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for FARSA
        Cytosolic tRNA aminoacylation


    1 Kegg Pathway  (Kegg details for FARSA):
        Aminoacyl-tRNA biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FARSA
    Interactions:

        Search GeneGlobe Interaction Network for FARSA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FARSA (Q9Y2851, 2, 3 ENSP000003203094) via UniProtKB, MINT, STRING, and/or I2D (see all 146)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006432phenylalanyl-tRNA aminoacylation IEA--
    GO:0010467gene expression TAS--
    GO:0043039tRNA aminoacylation ----

    Find genes that share ontologies with FARSA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FARSA (SYFA)

    1 HMDB Compound for FARSA    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Phenylalanine(-)-beta-Phenylalanine (see all 28)63-91-2--

    1 DrugBank Compound for FARSA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Phenylalanine(S)-alpha-Amino-beta-phenylpropionic acid (see all 4)63-91-2target--16338408 17139284 17016423 16969782



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FARSA gene: 
    NM_004461.2  

    Unigene Cluster for FARSA:

    Phenylalanyl-tRNA synthetase, alpha subunit
    Hs.23111  [show with all ESTs]
    Unigene Representative Sequence: BC043565
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000588025 ENST00000423140 ENST00000314606(uc002mvs.2 uc010xmv.1)
    ENST00000586146 ENST00000588965 ENST00000587488 ENST00000593021 ENST00000592662
    ENST00000586280 ENST00000587981
    miRNA
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    Block miRNA regulation of human, mouse, rat FARSA using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FARSA
    SwitchGear 3'UTR luciferase reporter plasmidFARSA 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FARSA
    Predesigned siRNA for gene silencing in human, mouse, rat FARSA
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    GenScript: all cDNA clones in your preferred vector: FARSA (NM_004461)
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    Primer
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    OriGene qPCR primer pairs and template standards for FARSA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FARSA
      QuantiTect SYBR Green Assays in human, mouse, rat FARSA
      QuantiFast Probe-based Assays in human, mouse, rat FARSA

    Additional mRNA sequence: 

    AF042347.1 AK092093.1 AK130195.1 AK304587.1 BC006495.2 BC035438.1 BC043565.1 BT007198.1 
    CR456740.1 D84471.1 U07424.1 

    19 DOTS entries:

    DT.100801300  DT.316428  DT.100878707  DT.97776402  DT.100835271  DT.100878716  DT.100878713  DT.121453850 
    DT.95239584  DT.100830629  DT.100878704  DT.121453889  DT.100805889  DT.100878706  DT.121453851  DT.121453874 
    DT.95266078  DT.95266070  DT.95266073 

    Selected AceView cDNA sequences (see all 488):

    BQ646701 BX376683 CB155181 CR617025 BI752993 BM799710 BM698808 BQ216695 
    BF882190 BM468267 BQ648100 BU171339 CR613870 BF971386 BI830287 BC043565 
    AA301554 CB118602 U07424 CR598884 BG761717 BM456768 BI335237 BF982130 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FARSA    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                                              -                                             
    SP2:                                                                                                            
    SP3:                                                                                                            
    SP4:                                                                                                            


    ECgene alternative splicing isoforms for FARSA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FARSA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCACTCTA
    FARSA Expression
    About this image


    FARSA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Spinal Cord (Nervous System)
    FARSA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FARSA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.23111
        Custom PCR Arrays for FARSA
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FARSA
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    QuantiFast Probe-based Assays in human, mouse, rat FARSA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FARSA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FARSA gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Farsa1 , 5 phenylalanyl-tRNA synthetase, alpha subunit1, 5 85.83(n)1
    92.52(a)1
      8 (41.23 cM)5
    665901  NM_025648.31  NP_079924.21 
     848569895 
    chicken
    (Gallus gallus)
    Aves FARSA1 phenylalanyl-tRNA synthetase, alpha subunit 75.95(n)
    76.83(a)
      100859604  NM_001271157.1  NP_001258086.1 
    lizard
    (Anolis carolinensis)
    Reptilia FARSA6
    phenylalanyl-tRNA synthetase, alpha subunit
    67(a)
    1 ↔ 1
    2(77729221-77741429)
    African clawed frog
    (Xenopus laevis)
    Amphibia farsl-prov2 phenylalanine-tRNA synthetase-like 75.58(n)    BC054256.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj21a112 Transcribed sequence with weak similarity to protein more 75.99(n)    CK028671.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG22631 CG2263 66.33(n)
    63.39(a)
      31740  NM_132220.4  NP_572448.1 
    worm
    (Caenorhabditis elegans)
    Secernentea fars-11 fars-1 58(n)
    61.19(a)
      172311  NM_059391.4  NP_491792.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FRS2(YFL022C)4
    FRS21
    Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, more4
    FRS21
    52.04(n)1
    51.97(a)1
      6(95010-93499)4
    8505221, 4  NP_116631.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G392801 AT4G39280 56.3(n)
    56.51(a)
      830084  NM_120089.4  NP_195639.2 
    rice
    (Oryza sativa)
    Liliopsida Os.31912 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.5(n)    AK068126.1 


    ENSEMBL Gene Tree for FARSA (if available)
    TreeFam Gene Tree for FARSA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FARSA gene
    1 SIMAP similar gene for FARSA using alignment to 7 protein entries:     SYFA_HUMAN (see all proteins):
    FARSLA

    Find genes that share paralogs with FARSA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FARSA (see all 342)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1117309331,2
    C--13032847(+) CTTGAA/CCTCAT 1 -- ds50011Minor allele frequency- C:0.00CSA 1
    rs75082251,2
    C,F,A--13032851(+) acctcG/Atgatc 1 -- ds50017Minor allele frequency- A:0.21NA WA CSA 14
    rs1124433021,2
    C--13032853(+) CTCATA/GATCCA 1 -- ds50011Minor allele frequency- G:0.00CSA 1
    rs75082261,2
    C,F,A--13032867(+) gcctcG/Agcctc 1 -- ds50015Minor allele frequency- A:0.20NA WA 10
    rs116733461,2
    C,A,H--13032940(+) AGAGAC/TGGGGT 1 -- ds50018Minor allele frequency- T:0.07NA WA CSA 15
    rs29678931,2
    C,A,H--13033062(-) AAAGTC/ATGGGT 1 -- ds50019Minor allele frequency- A:0.25NA WA CSA 250
    rs1834929341,2
    --13033191(+) ACGCGG/TGCCAC 1 -- ds50010--------
    rs789377391,2
    C--13033514(+) GGAGCG/ACAGCA 1 -- ut312Minor allele frequency- A:0.01WA EU 1409
    rs1431115151,2
    C--13033565(+) TGTCAC/TGCAGC 2 A syn10--------
    rs2001992311,2
    --13033660(+) CACCAA/GCTCCC 2 L syn10--------

    HapMap Linkage Disequilibrium report for FARSA (13033284 - 13044851 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FARSA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911082CNV Loss21882294
    nsv833754CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FARSA
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602918    OMIM disorders: --

    1 disease for FARSA:    
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    impetigo

    1 disease from the University of Copenhagen DISEASES database for FARSA:
    Impetigo

    Find genes that share disorders with FARSA           About GenesLikeMe


    Export disorders for FARSA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FARSA gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with FARSA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent. (PubMed id 9177188)1, 2, 3, 9 Sen S....White R.A. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    5. Human phenylalanyl-tRNA synthetase: cloning, characterization of the deduced amino acid sequences in terms of the structural domains and coordinately regulated expression of the alpha and beta subunits in chronic myeloid leukemia cells. (PubMed id 10049785)1, 2 Rodova M.... Safro M.G. (Biochem. Biophys. Res. Commun. 1999)
    6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    7. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)
    8. Seventy-five genetic loci influencing the human red blood cell. (PubMed id 23222517)1 van der Harst P....Chambers J.C. (Nature 2012)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2193 HGNC: 3592 AceView: FARSLA Ensembl:ENSG00000179115 euGenes: HUgn2193
    ECgene: FARSA Kegg: 2193 H-InvDB: FARSA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FARSA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FARSA gene:
    Search GeneIP for patents involving FARSA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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