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Aliases for FARSA Gene

Aliases for FARSA Gene

  • Phenylalanyl-TRNA Synthetase, Alpha Subunit 2 3
  • Phenylalanyl-TRNA Synthetase-Like, Alpha Subunit 2 3
  • EC 6.1.1.20 4 63
  • FARSLA 3 4
  • PheRS 3 4
  • FARSL 3 4
  • CML33 3 4
  • Phenylalanine-TRNA Synthetase-Like, Alpha Subunit 3
  • Phenylalanine TRNA Ligase 1, Alpha, Cytoplasmic 3
  • Phenylalanine-TRNA Synthetase Alpha-Subunit 3
  • Phenylalanyl-TRNA Synthetase Alpha Subunit 4
  • Phenylalanine--TRNA Ligase Alpha Subunit 3
  • Phenylalanyl-TRNA Synthetase Alpha Chain 3
  • Phenylalanine--TRNA Ligase Alpha Chain 3
  • Phenylalanine-TRNA Synthetase-Like 2
  • Phenylalanine TRNA Ligase 1 2
  • Cytoplasmic 2
  • Alpha 2
  • PheHA 3
  • FRSA 3
  • FARS 4

External Ids for FARSA Gene

Previous HGNC Symbols for FARSA Gene

  • FARSL
  • FARSLA

Previous GeneCards Identifiers for FARSA Gene

  • GC19M012895
  • GC19M013033
  • GC19M012605

Summaries for FARSA Gene

Entrez Gene Summary for FARSA Gene

  • Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a product which is similar to the catalytic subunit of prokaryotic and Saccharomyces cerevisiae phenylalanyl-tRNA synthetases (PheRS). This gene product has been shown to be expressed in a tumor-selective and cell cycle stage- and differentiation-dependent manner, the first member of the tRNA synthetase gene family shown to exhibit this type of regulated expression [provided by RefSeq, Jul 2008]

GeneCards Summary for FARSA Gene

FARSA (Phenylalanyl-TRNA Synthetase, Alpha Subunit) is a Protein Coding gene. Diseases associated with FARSA include impetigo. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include tRNA binding and phenylalanine-tRNA ligase activity.

Gene Wiki entry for FARSA Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FARSA Gene

Genomics for FARSA Gene

Regulatory Elements for FARSA Gene

Genomic Location for FARSA Gene

Start:
12,922,470 bp from pter
End:
12,934,037 bp from pter
Size:
11,568 bases
Orientation:
Minus strand

Genomic View for FARSA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FARSA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FARSA Gene

Proteins for FARSA Gene

  • Protein details for FARSA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y285-SYFA_HUMAN
    Recommended name:
    Phenylalanine--tRNA ligase alpha subunit
    Protein Accession:
    Q9Y285
    Secondary Accessions:
    • B4E363
    • Q9NSD8
    • Q9Y4W8

    Protein attributes for FARSA Gene

    Size:
    508 amino acids
    Molecular mass:
    57564 Da
    Quaternary structure:
    • Tetramer of two alpha and two beta subunits.
    SequenceCaution:
    • Sequence=AAB51175.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FARSA Gene

    Alternative splice isoforms for FARSA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FARSA Gene

Proteomics data for FARSA Gene at MOPED

Post-translational modifications for FARSA Gene

  • Ubiquitination at Lys59, Lys101, Lys106, Lys150, Lys177, Lys187, Lys208, Lys311, Lys315, Lys349, Lys406, Lys468, and Lys481
  • Modification sites at PhosphoSitePlus

Other Protein References for FARSA Gene

Domains for FARSA Gene

Gene Families for FARSA Gene

HGNC:
  • aaRS2 :Aminoacyl tRNA synthetases / Class II

Graphical View of Domain Structure for InterPro Entry

Q9Y285

UniProtKB/Swiss-Prot:

SYFA_HUMAN :
  • Q9Y285
Family:
  • Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
genes like me logo Genes that share domains with FARSA: view

Function for FARSA Gene

Molecular function for FARSA Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)

Enzyme Numbers (IUBMB) for FARSA Gene

Gene Ontology (GO) - Molecular Function for FARSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0000166 nucleotide binding --
GO:0004812 aminoacyl-tRNA ligase activity --
GO:0004826 phenylalanine-tRNA ligase activity IEA --
GO:0005515 protein binding IPI 21163940
genes like me logo Genes that share ontologies with FARSA: view
genes like me logo Genes that share phenotypes with FARSA: view

miRNA for FARSA Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for FARSA Gene

Localization for FARSA Gene

Subcellular locations from UniProtKB/Swiss-Prot for FARSA Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FARSA Gene COMPARTMENTS Subcellular localization image for FARSA gene
Compartment Confidence
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for FARSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9177188
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with FARSA: view

Pathways for FARSA Gene

genes like me logo Genes that share pathways with FARSA: view

Pathways by source for FARSA Gene

1 KEGG pathway for FARSA Gene

Gene Ontology (GO) - Biological Process for FARSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006432 phenylalanyl-tRNA aminoacylation IEA --
GO:0010467 gene expression TAS --
GO:0043039 tRNA aminoacylation --
genes like me logo Genes that share ontologies with FARSA: view

Compounds for FARSA Gene

(1) HMDB Compounds for FARSA Gene

Compound Synonyms Cas Number PubMed IDs
L-Phenylalanine
  • (-)-beta-Phenylalanine
63-91-2

(1) Drugbank Compounds for FARSA Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Phenylalanine
  • (S)-alpha-Amino-beta-phenylpropionic acid
63-91-2 target
genes like me logo Genes that share compounds with FARSA: view

Transcripts for FARSA Gene

Unigene Clusters for FARSA Gene

Phenylalanyl-tRNA synthetase, alpha subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FARSA Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2:
SP3:
SP4:

Relevant External Links for FARSA Gene

GeneLoc Exon Structure for
FARSA
ECgene alternative splicing isoforms for
FARSA

Expression for FARSA Gene

mRNA expression in normal human tissues for FARSA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FARSA Gene

SOURCE GeneReport for Unigene cluster for FARSA Gene Hs.23111

genes like me logo Genes that share expressions with FARSA: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FARSA Gene

Orthologs for FARSA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FARSA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FARSA 35
  • 99.67 (n)
  • 99.61 (a)
FARSA 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FARSA 35
  • 89.63 (n)
  • 94.49 (a)
FARSA 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FARSA 35
  • 89.96 (n)
  • 94.88 (a)
FARSA 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Farsa 35
  • 85.83 (n)
  • 92.52 (a)
Farsa 16
Farsa 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FARSA 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FARSA 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Farsa 35
  • 85.5 (n)
  • 92.52 (a)
chicken
(Gallus gallus)
Aves FARSA 35
  • 75.95 (n)
  • 76.83 (a)
FARSA 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FARSA 36
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia farsl-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia farsa 35
  • 72.08 (n)
  • 75.29 (a)
Str.3839 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10382 35
zebrafish
(Danio rerio)
Actinopterygii farsa 35
  • 74.04 (n)
  • 77.87 (a)
farsa 36
  • 78 (a)
OneToOne
wufj21a11 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002653 35
  • 62.39 (n)
  • 57.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2263 35
  • 66.33 (n)
  • 63.39 (a)
CG2263 36
  • 62 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea fars-1 35
  • 58 (n)
  • 61.19 (a)
fars-1 36
  • 53 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR516W 35
  • 57.76 (n)
  • 52.32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FRS2 35
  • 52.04 (n)
  • 51.97 (a)
FRS2 36
  • 48 (a)
OneToOne
FRS2 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F25234g 35
  • 51.63 (n)
  • 49.9 (a)
soybean
(Glycine max)
eudicotyledons Gma.12602 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G39280 35
  • 56.3 (n)
  • 56.51 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.10634 35
corn
(Zea mays)
Liliopsida Zm.5623 35
rice
(Oryza sativa)
Liliopsida Os.3191 35
Os10g0400800 35
  • 58.32 (n)
  • 55.65 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.1529 35
bread mold
(Neurospora crassa)
Ascomycetes NCU05095 35
  • 60.47 (n)
  • 55.35 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes frs2 35
  • 50.51 (n)
  • 53.95 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11498 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1858 36
  • 63 (a)
OneToOne
Species with no ortholog for FARSA:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for FARSA Gene

ENSEMBL:
Gene Tree for FARSA (if available)
TreeFam:
Gene Tree for FARSA (if available)

Paralogs for FARSA Gene

Selected SIMAP similar genes for FARSA Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with FARSA: view

No data available for Paralogs for FARSA Gene

Variants for FARSA Gene

Sequence variations from dbSNP and Humsavar for FARSA Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1045913 -- 12,924,192(-) CTTCC(C/T)GAGAA reference, synonymous-codon
rs1804567 -- 12,924,162(-) GGCCT(C/T)TCCCT reference, synonymous-codon
rs2009218 -- 12,923,770(+) ccacc(A/G)cgcct intron-variant
rs2009222 -- 12,923,729(+) cctgc(C/T)tcagc intron-variant
rs2293683 -- 12,928,470(+) GAGAC(A/G)CAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FARSA Gene

Variant ID Type Subtype PubMed ID
nsv911082 CNV Loss 21882294
nsv833754 CNV Loss 17160897

Relevant External Links for FARSA Gene

HapMap Linkage Disequilibrium report
FARSA
Human Gene Mutation Database (HGMD)
FARSA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FARSA Gene

Disorders for FARSA Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for FARSA Gene including...

Search for FARSA Gene in MalaCards »

(1) University of Copenhagen DISEASES for FARSA Gene

genes like me logo Genes that share disorders with FARSA: view

No data available for UniProtKB/Swiss-Prot for FARSA Gene

Publications for FARSA Gene

  1. Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent. (PMID: 9177188) Sen S. … White R.A. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23
  2. Human phenylalanyl-tRNA synthetase: cloning, characterization of the deduced amino acid sequences in terms of the structural domains and coordinately regulated expression of the alpha and beta subunits in chronic myeloid leukemia cells. (PMID: 10049785) Rodova M. … Safro M.G. (Biochem. Biophys. Res. Commun. 1999) 3 4
  3. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4

Products for FARSA Gene

Sources for FARSA Gene

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