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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FARSA Gene

protein-coding GIFtS: 61
GCID: GC19M013033

phenylalanyl-tRNA synthetase, alpha subunit

(Previous names: phenylalanine-tRNA synthetase-like, phenylalanyl-tRNA synthetase-like,...)
(Previous symbols: FARSL, FARSLA)

Explore 11 diseases affiliated with
FARSA via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Phenylalanyl-TRNA Synthetase, Alpha Subunit¹ ²		Phenylalanine TRNA Ligase 1, Alpha, Cytoplasmic²
CML33¹ ² ³		Phenylalanine--TRNA Ligase Alpha Chain²
FARSL¹ ² ³		Phenylalanine--TRNA Ligase Alpha Subunit²
FARSLA¹ ² ³		Phenylalanine-TRNA Synthetase Alpha-Subunit²
Phenylalanyl-TRNA Synthetase-Like, Alpha Subunit¹ ²		Phenylalanine-TRNA Synthetase-Like, Alpha Subunit²
EC 6.1.1.20³ ⁸		Phenylalanyl-TRNA Synthetase Alpha Chain²
Phenylalanine-TRNA Synthetase-Like¹		FARS³
FRSA²		PheRS³
PheHA²		Phenylalanyl-TRNA Synthetase Alpha Subunit³
PheRS³

External Ids:	HGNC: 3592¹	Entrez Gene: 2193²	Ensembl: ENSG00000179115⁷	OMIM: 602918⁵	UniProtKB: Q9Y285³

Export aliases for FARSA gene to outside databases

Previous GC identifers: GC19M012895 GC19M012605

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FARSA:

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a

product which is similar to the catalytic subunit of prokaryotic and Saccharomyces cerevisiae phenylalanyl-tRNA

synthetases (PheRS). This gene product has been shown to be expressed in a tumor-selective and cell cycle stage- and

differentiation-dependent manner, the first member of the tRNA synthetase gene family shown to exhibit this type of

regulated expression (provided by RefSeq, Jul 2008)

Gene Wiki entry for FARSA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011295.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FARSA gene promoter:
p53 ATF-2 CUTL1 Nkx2-5 c-Jun NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FARSA promoter sequence

Search SABiosciences Chromatin IP Primers for FARSA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FARSA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2

FARSA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FARSA gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M013033: view genomic region (about GC identifiers)

Start:	13,033,284 bp from pter	End:	13,044,851 bp from pter
Size:	11,568 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SYFA_HUMAN, Q9Y285 (See protein sequence)

Recommended Name: Phenylalanine--tRNA ligase alpha subunit

Size: 508 amino acids; 57564 Da

Subunit: Tetramer of two alpha and two beta subunits (By similarity)

Subcellular location: Cytoplasm (By similarity)

Sequence caution: Sequence=AAB51175.1; Type=Erroneous gene model prediction;

1 PDB 3D structure from and Proteopedia for FARSA:

3L4G (3D)

Secondary accessions: Q9NSD8 Q9Y4W8

Explore the universe of human proteins at neXtProt for FARSA: NX_Q9Y285

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y285

4/13 DME Specific Peptides for FARSA (Q9Y285) (see all 13)

VGFSKAM

FWNFDAL

MGFTEMP

IFLEMGF

FARSA Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004452.1

ENSEMBL proteins:

ENSP00000468051 ENSP00000396548 ENSP00000320309 ENSP00000468068 ENSP00000468384

ENSP00000467384 ENSP00000465402

Reactome Protein details: Q9Y285
Human Recombinant Protein Products:

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	Novus Biologicals FARSA Proteins Novus Biologicals FARSA Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005625	soluble fraction	--	--
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	TAS	--

FARSA for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FARSA for domains About GeneDecksing

4 InterPro domains/families:

IPR006195 aa-tRNA-synth_II

IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

IPR004529 Phe-tRNA-synth_IIc_asu

IPR002319 Phenylalanyl-tRNA_Synthase

Graphical View of Domain Structure for InterPro Entry Q9Y285

ProtoNet protein and cluster: Q9Y285

2 Blocks protein families:

IPB002319 Phenylalanyl-tRNA synthetase

IPB013196 Helix-turn-helix

UniProtKB/Swiss-Prot: SYFA_HUMAN, Q9Y285

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2

subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SYFA_HUMAN, Q9Y285

Catalytic activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)

Enzyme Number (IUBMB): EC 6.1.1.20¹ ²

miRNA Products:		OriGene 3'-UTR Clone: FARSA Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FARSA
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		SwitchGear 3'UTR luciferase reporter plasmid: FARSA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FARSA (see all 7) OriGene shRNA RFP: FARSA OriGene siRNA: FARSA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FARSA

Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FARSA

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000049	tRNA binding	IEA	--
GO:0004826	phenylalanine-tRNA ligase activity	IEA	--
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	IEA	--

FARSA for ontologies About GeneDecksing

Animal Models:
5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Farsa):

growth/size

hematopoietic system

immune system

mortality/aging

skeleton

FARSA for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

tRNA Aminoacylation

	tRNA Aminoacylation	1.00			Aminoacyl-tRNA biosynthesis	0.54
	Cytosolic tRNA aminoacylation	0.57

Generic Transcription Pathway

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Reactome Pathways for FARSA

	Cytosolic tRNA aminoacylation
	tRNA Aminoacylation
	Gene Expression

1 Kegg Pathway (Kegg details for FARSA):

Aminoacyl-tRNA biosynthesis

FARSA for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FARSA

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

5/91 Interacting proteins for FARSA (Q9Y285^{1, 2, 3} ENSP00000320309⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 91)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=1
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1
HIST1H4E	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006418	tRNA aminoacylation for protein translation	TAS	--
GO:0006432	phenylalanyl-tRNA aminoacylation	IEA	--
GO:0010467	gene expression	TAS	--

FARSA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FARSA

1 HMDB Compound for FARSA About this table

Compound	Synonyms	CAS #	PubMed Ids
L-Phenylalanine	(-)-beta-Phenylalanine (see all 28)	63-91-2	--

1 DrugBank Compound for FARSA About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
L-Phenylalanine	(S)-alpha-Amino-beta-phenylpropionic acid (see all 4)	63-91-2	target	--	16338408 17139284 17016423 16969782

Search CenterWatch for drugs/clinical trials and news about FARSA / SYFA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FARSA gene:

NM_004461.2

Unigene Cluster for FARSA:

Phenylalanyl-tRNA synthetase, alpha subunit

Hs.23111 [show with all ESTs]

Unigene Representative Sequence: BC043565

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000588025 ENST00000423140 ENST00000314606(uc002mvs.2 uc010xmv.1)

ENST00000586146 ENST00000588965 ENST00000587488 ENST00000593021 ENST00000592662

ENST00000586280 ENST00000587981

miRNA Products:		OriGene 3'-UTR Clone: FARSA Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FARSA
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate FARSA
		SwitchGear 3'UTR luciferase reporter plasmid: FARSA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FARSA (see all 7) OriGene shRNA RFP: FARSA OriGene siRNA: FARSA
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FARSA (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FARSA OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FARSA (NM_004461)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FARSA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FARSA

Additional cDNA sequence:

AF042347.1 AK092093.1 AK130195.1 AK304587.1 BC006495.2 BC035438.1 BC043565.1 BT007198.1

CR456740.1 D84471.1 U07424.1

19 DOTS entries:

DT.100801300 DT.316428 DT.100878707 DT.97776402 DT.100835271 DT.100878716 DT.100878713 DT.121453850

DT.95239584 DT.100830629 DT.100878704 DT.121453889 DT.100805889 DT.100878706 DT.121453851 DT.121453874

DT.95266078 DT.95266070 DT.95266073

24/488 AceView cDNA sequences (see all 488):

CA454852 CR605875 BI756468 BU845589 CR596139 BX282522 BQ942933 BQ276511

BQ683300 CR604250 BX366963 AU122736 CR613342 BG827163 AK092093 CR613659

CR617949 BM852683 BU542821 CF134942 BX376683 CR617025 CB155181 BI752993

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for FARSA About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	^	7	^	8	^	9	^	10	^	11	^	12	^	13
SP1:																					-
SP2:
SP3:
SP4:

ECgene alternative splicing isoforms for FARSA

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FARSA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCCACTCTA

About this image

FARSA expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Brain

Medulla Oblongata

Brain

Spinal Cord

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FARSA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FARSA

SOURCE GeneReport for Unigene cluster: Hs.23111

SABiosciences Custom PCR Arrays for FARSA

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FARSA

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FARSA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for FARSA gene from 11/45 species (see all 45) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Farsa^{1 , 5}	phenylalanyl-tRNA synthetase, alpha subunit^{1, 5}	85.83(n)¹ 92.52(a)¹		8 (41.23 cM)⁵ 66590¹ NM_025648.3¹ NP_079924.2¹ 84856989⁵
chicken (Gallus gallus)	Aves	FARSA¹	phenylalanyl-tRNA synthetase, alpha subunit	80.78(n) 87.45(a)		100859604 XM_003643386.1 XP_003643434.1
lizard (Anolis carolinensis)	Reptilia	FARSA⁶ FARS2⁶	--	79(a) 19(a)	1 ↔ 1 possible ortholog	2(77729221-77740794) GL343421.1(190952-196990)
African clawed frog (Xenopus laevis)	Amphibia	farsl-prov²	phenylalanine-tRNA synthetase-like	75.58(n)		BC054256.1
zebrafish (Danio rerio)	Actinopterygii	wufj21a11²	Transcribed sequence with weak similarity to protein more	75.99(n)		CK028671.1
fruit fly (Drosophila melanogaster)	Insecta	CG2263¹	CG2263	66.33(n) 63.39(a)		31740 NM_132220.3 NP_572448.1
worm (Caenorhabditis elegans)	Secernentea	fars-1¹	Protein FARS-1	58.05(n) 61.32(a)		172311 NM_059391.3 NP_491792.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	FRS2(YFL022C)⁴ FRS2¹	Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, more⁴ Frs2p¹	51.82(n)¹ 51.75(a)¹		6(95010-93499)⁴ 850522^{1, 4} NP_116631.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G39280¹	phenylalanyl-tRNA synthetase alpha chain	56.16(n) 56.09(a)		830084 NM_120089.4 NP_195639.2
rice (Oryza sativa)	Liliopsida	Os.3191²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	74.5(n)		AK068126.1

ENSEMBL Gene Tree for FARSA (if available)
TreeFam Gene Tree for FARSA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111730933^1,2	C	--	13032847(+)	`CTTGAA/CCTCAT`	1	--	ds500¹		1		CSA	1
rs7508225^1,2	C,F,A,	--	13032851(+)	`ACCTCG/ATGATC`	1	--	ds500¹		7		NA WA CSA	14
rs112443302^1,2	C	--	13032853(+)	`CTCATA/GATCCA`	1	--	ds500¹		1		CSA	1
rs7508226^1,2	C,F,A,	--	13032867(+)	`GCCTCG/AGCCTC`	1	--	ds500¹		5		NA WA	10
rs11673346^1,2	C,A,H,	--	13032940(+)	`AGAGAC/TGGGGT`	1	--	ds500¹		8		NA WA CSA	15
rs2967893^1,2	C,A,H,	--	13033062(-)	`AAAGTC/ATGGGT`	1	--	ds500¹		9		NA WA CSA	250
rs183492934^1,2		--	13033191(+)	`ACGCGG/TGCCAC`	1	--	ds500¹		0	--	--	--	--
rs78937739^1,2	C,	--	13033514(+)	`GGAGCG/ACAGCA`	1	--	ut3¹		2		WA EU	1409
rs143111515^1,2	C,	--	13033565(+)	`TGTCAC/TGCAGC`	2	A	syn¹		0	--	--	--	--
rs200199231^1,2		--	13033660(+)	`CACCAA/GCTCCC`	2	L	syn¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FARSA (13033284 - 13044851 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FARSA
1 CNV: 4400

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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FARSA for disorders           About GeneDecksing

OMIM gene information: 602918    OMIM disorders: --

11 diseases for FARSA:    About MalaCards

impetigo polyhydramnios chronic myeloid leukemia myeloid leukemia

polymyositis leukemia pneumonia schizophrenia

tuberculosis malaria mycobacterium tuberculosis

1 disease from the University of Copenhagen DISEASES database for FARSA:

Impetigo

Export disorders for FARSA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for FARSA gene, integrated from 9 sources (see all 36):
(articles sorted by number of sources associating them with FARSA)

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Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent. (PubMed id 9177188)^{1, 2, 3, 9} Sen S....White R.A. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{1, 2} Grimwood J.... Lucas S.M. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (2003)
Human phenylalanyl-tRNA synthetase: cloning, characterization of the deduced amino acid sequences in terms of the structural domains and coordinately regulated expression of the alpha and beta subunits in chronic myeloid leukemia cells. (PubMed id 10049785)^{1, 2} Rodova M.... Safro M.G. (1999)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)¹ Aichem A....Groettrup M. (2012)
Proteomic identification of common SCF ubiquitin ligas e FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)¹ Liu B....Wang L.S. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2193	HGNC: 3592	AceView: FARSLA	Ensembl:ENSG00000179115	euGenes: HUgn2193
ECgene: FARSA	Kegg: 2193	H-InvDB: FARSA

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for FARSA	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FARSA gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for FARSA gene:
Search GeneIP for patents involving FARSA

GeneCards and IP:
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FARSA Gene

phenylalanyl-tRNA synthetase, alpha subunit

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FARSA (Gene Symbol)
Phenylalanyl-TRNA Synthetase, Alpha Subunit
CML33
FARSL
FARSLA
Phenylalanyl-TRNA Synthetase-Like, Alpha Subunit
EC 6.1.1.20
Phenylalanine-TRNA Synthetase-Like
FRSA
PheHA
PheRS
Phenylalanine TRNA Ligase 1, Alpha, Cytoplasmic
Phenylalanine--TRNA Ligase Alpha Chain
Phenylalanine--TRNA Ligase Alpha Subunit
Phenylalanine-TRNA Synthetase Alpha-Subunit
Phenylalanine-TRNA Synthetase-Like, Alpha Subunit
Phenylalanyl-TRNA Synthetase Alpha Chain
FARS
PheRS
Phenylalanyl-TRNA Synthetase Alpha Subunit

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FARSA Gene

phenylalanyl-tRNA synthetase, alpha subunit

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