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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FARS2 Gene

protein-coding   GIFtS: 64
GCID: GC06P005207

phenylalanyl-tRNA synthetase 2, mitochondrial

(Previous name: phenylalanine-tRNA synthetase 1 (mitochondrial) )
(Previous symbol: FARS1)
 Explore 2 diseases affiliated with
FARS2 via our new
 Human Malady Compendium 
Biological research products
for FARS2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Phenylalanyl-TRNA Synthetase 2, Mitochondrial1 2     DJ236A3.1 (Phenylalanine-TRNA Synthetase)2
FARS11 2 3 5     DJ520B18.2 (FARS1 (Phenylalanine-TRNA Synthetase))2
Phenylalanine-TRNA Synthetase 1 (Mitochondrial)1 2     Phenylalanine Translase2
PheRS2 3     Phenylalanine TRNA Ligase 2, Mitochondrial2
EC 6.1.1.203 8     Phenylalanine--TRNA Ligase, Mitochondrial2
DJ236A3.11     Phenylalanine-TRNA Synthetase 2 (Mitochondrial)2
COXPD142     Phenylalanyl-TRNA Synthetase3
HSPC3202     EC 6.1.18
DJ520B18.21     

External Ids:    HGNC: 210621   Entrez Gene: 106672   Ensembl: ENSG000001459827   OMIM: 6115925   UniProtKB: O953633   

Export aliases for FARS2 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FARS2:
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a
phenylalanine-tRNA synthetase (PheRS) localized to the mitochondrion which consists of a single polypeptide chain,
unlike the (alpha-beta)2 structure of the prokaryotic and eukaryotic cytoplasmic forms of PheRS. Structure analysis
and catalytic properties indicate mitochondrial PheRSs may constitute a class of PheRS distinct from the enzymes found
in prokaryotes and in the eukaryotic cytoplasm. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SYFM_HUMAN, O95363
Function: Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment
of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of
ROS-damaged amino acid into proteins

Gene Wiki entry for FARS2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FARS2 gene promoter:
         HOXA3   Brachyury   NRSF form 1   NRSF form 2   MEF-2A   PPAR-gamma1   FOXO1a   aMEF-2   PPAR-gamma2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFARS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FARS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FARS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25.1   Ensembl cytogenetic band:  6p25.1   HGNC cytogenetic band: 6p25.1

FARS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FARS2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P005207:  view genomic region     (about GC identifiers)

Start:
5,261,584 bp from pter      End:
5,771,816 bp from pter
Size:
510,233 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SYFM_HUMAN, O95363 (See protein sequence)
Recommended Name: Phenylalanine--tRNA ligase, mitochondrial precursor  
Size: 451 amino acids; 52357 Da
Subunit: Monomer
Subcellular location: Mitochondrion matrix (Potential)
Sequence caution: Sequence=AAF28998.1; Type=Frameshift; Positions=414;
4 PDB 3D structures from and Proteopedia for FARS2:
3CMQ (3D)        3HFV (3D)        3TEG (3D)        3TUP (3D)    
Secondary accessions: B2R664 Q53F66 Q5TCS3 Q6FG29 Q9NPY7 Q9P062

Explore the universe of human proteins at neXtProt for FARS2: NX_O95363

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95363

  • 3 DME Specific Peptides for FARS2 (O95363)
     GLERLAM  IPDIRLFW  WLEVLGCG 

    FARS2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006558.1  
    ENSEMBL proteins: 
     ENSP00000316335   ENSP00000392525   ENSP00000274680  
    Reactome Protein details: O95363
    Human Recombinant Protein Products: 
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    Uscn Proteins for FARS2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion ----
    GO:0005759mitochondrial matrix TAS--


    FARS2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for FARS2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    FARS2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR006195 aa-tRNA-synth_II
     IPR005121 PheS_beta_Fdx_antiC-bd
     IPR004530 Phe-tRNA-synth_IIc_mito
     IPR002319 Phenylalanyl-tRNA_Synthase

    Graphical View of Domain Structure for InterPro Entry O95363

    ProtoNet protein and cluster: O95363

    2 Blocks protein families:
    IPB002319 Phenylalanyl-tRNA synthetase
    IPB005121 Ferredoxin-fold anticodon binding domain


    UniProtKB/Swiss-Prot: SYFM_HUMAN, O95363
    Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family
    Similarity: Contains 1 FDX-ACB domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SYFM_HUMAN, O95363
    Function: Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment
    of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of
    ROS-damaged amino acid into proteins
    Catalytic activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)

    Enzyme Numbers (IUBMB): EC 6.1.1.201 2 EC 6.1.12

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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000049tRNA binding IDA10329163
    GO:0000287magnesium ion binding IEA--
    GO:0004812aminoacyl-tRNA ligase activity ----
    GO:0004826phenylalanine-tRNA ligase activity IDA10329163
    GO:0005524ATP binding IEA--


    FARS2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for FARS2:
     Synthetic lethal with Ras 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1tRNA Aminoacylation
    tRNA Aminoacylation1.00
    Mitochondrial tRNA aminoacylation0.50
    Aminoacyl-tRNA biosynthesis0.54
    2Generic Transcription Pathway
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for FARS2
        tRNA Aminoacylation
    Gene Expression
    Mitochondrial tRNA aminoacylation


    1         Kegg Pathway  (Kegg details for FARS2):
        Aminoacyl-tRNA biosynthesis


    FARS2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FARS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/263 Interacting proteins for FARS2 (O953632, 3 ENSP000002746804) via UniProtKB, MINT, STRING, and/or I2D (see all 263)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AFG3L2Q9Y4W62, 3MINT-8079030 I2D: score=1 
    VDAC3Q9Y2772, 3MINT-8079030 I2D: score=1 
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    GCN1L1Q926163, ENSP000003006484I2D: score=1 STRING: ENSP00000300648
    MTIF2P461993, ENSP000002636294I2D: score=1 STRING: ENSP00000263629
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006432phenylalanyl-tRNA aminoacylation IDA10329163
    GO:0008033tRNA processing IDA10329163
    GO:0010467gene expression TAS--
    GO:0043039tRNA aminoacylation ----


    FARS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for FARS2

    5 HMDB Compounds for FARS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Phenylalanine(-)-beta-Phenylalanine (see all 28)63-91-2--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for FARS2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Phenylalanine(S)-alpha-Amino-beta-phenylpropionic acid (see all 4)63-91-2target--16338408 17139284 17016423 16969782

    Search CenterWatch for drugs/clinical trials and news about FARS2 / SYFM 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FARS2 gene: 
    NM_006567.3  

    Unigene Cluster for FARS2:

    Phenylalanyl-tRNA synthetase 2, mitochondrial
    Hs.484547  [show with all ESTs]
    Unigene Representative Sequence: AK001146
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324331 ENST00000445533 ENST00000274680(uc010jnv.1 uc003mwr.2)


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    Additional cDNA sequence: 

    AF097441.1 AF161438.1 AK001146.1 AK223423.1 AK312454.1 BC020239.1 BC021112.1 CR542279.1 

    13 DOTS entries:

    DT.113666  DT.100775351  DT.100775348  DT.91818027  DT.121343587  DT.91896131  DT.100019529  DT.100019530 
    DT.102831491  DT.91931536  DT.95181349  DT.95187167  DT.97791151 

    24/143 AceView cDNA sequences (see all 143):

    CA421065 AA486503 CR626764 BX426509 BE094254 BE792999 AL536987 AW452980 
    Z46093 AL514552 BF514670 CR594172 BI761156 BI764581 AL530356 CR542279 
    AA724346 AL544087 BG216750 BI909293 CR599212 BM981072 BU193742 BQ430823 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FARS2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
    SP1:        -                                                   
    SP2:        -                                                   
    SP3:                                                            


    ECgene alternative splicing isoforms for FARS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FARS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAACGGACTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See FARS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FARS2

    SOURCE GeneReport for Unigene cluster: Hs.484547
        SABiosciences Custom PCR Arrays for FARS2
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for FARS2 gene from 9/42 species (see all 42)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves FARS21 phenylalanyl-tRNA synthetase 2, mitochondrial 74.28(n)
    77.67(a)
      428482  XM_426039.3  XP_426039.2 
    lizard
    (Anolis carolinensis)
    Reptilia FARS26
    FARSA6
    --
    74(a)
    13(a)
    1 ↔ 1
    possible ortholog
    GL343421.1(190952-196990)
    2(77729221-77740794)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.176902 Transcribed sequence with moderate similarity to protein more 74.98(n)    AL920221.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Aats-phe1 Phenylalanyl-tRNA synthetase 55.71(n)
    53.19(a)
      36547  NM_057935.4  NP_477283.1 
    worm
    (Caenorhabditis elegans)
    Secernentea fars-21 Protein FARS-2 51.85(n)
    50.48(a)
      180303  NM_075451.4  NP_507852.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MSF1(YPR047W)4
    MSF11
    Mitochondrial phenylalanyl-tRNA synthetase, active more4
    Msf1p1
    47.23(n)1
    41.94(a)1
      16(657529-658938)4
    8561601, 4  NP_015372.21, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G581401 phenylalanyl-tRNA synthetase 54.19(n)
    50.84(a)
      824983  NM_115676.2  NP_567061.1 
    rice
    (Oryza sativa)
    Liliopsida Os.277722 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 71.78(n)    AK099502.1 
    E. coli
    (Escherichia coli)
    Gamma proteobacteria pheS6
    phenylalanine tRNA synthetase, alpha subunit
    25(a)
    1 ↔ 1
    Chromosome(1795983-1796966)


    ENSEMBL Gene Tree for FARS2 (if available)
    TreeFam Gene Tree for FARS2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FARS2 gene
    FDXACB12  ENSG000002585292  

    FARS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/10010 NCBI SNPs in FARS2 are shown (see all 10010    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs666361031,2
    C,--5259593(+) TATGCT/-TATTA 4 -- us2k1 int11Minor allele frequency- -:0.50NA 2
    rs1388142501,2
    --5259726(+) GCAGCA/CTGAGT 4 -- us2k1 int10--------
    rs1927546041,2
    --5259786(+) CTTAGC/TGTTCC 4 -- us2k1 int10--------
    rs1407292511,2
    C,--5259811(+) GTTGT-/AACTGG 4 -- us2k1 int10--------
    rs132131751,2
    C,F,--5259868(+) GGCCTC/ACCTAA 4 -- us2k1 int12Minor allele frequency- A:0.50NA 4
    rs1848062301,2
    --5259920(+) AATCCA/TCAGTC 4 -- int1 us2k10--------
    rs715408581,2
    C,--5260030(+) TTAGT-/AAAAAA 4 -- int1 us2k11Minor allele frequency- A:0.50NA 2
    rs1487001311,2
    --5260062(+) TCTAAA/GAAAAA 4 -- int1 us2k10--------
    rs1901270711,2
    --5260129(+) GCAGAA/GGCTCT 4 -- int1 us2k10--------
    rs1421552481,2
    --5260171(+) AAAAGA/TCTCAT 4 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for FARS2 (5261584 - 5511584 bp, first 250kb of FARS2)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for FARS2
         1 CNV: 51928
         2 Indels: 51929 11282
    Human Gene Mutation Database (HGMD): FARS2

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FARS2 for disorders           About GeneDecksing

    OMIM gene information: 611592    OMIM disorders: --

    2 diseases for FARS2:    About MalaCards
    mitochondrial encephalomyopathy    encephalomyopathy

    2 diseases from the University of Copenhagen DISEASES database for FARS2:
    Alpers syndrome     Mitochondrial encephalomyopathy
    Human Genome Epidemiology (HuGE) Navigator: FARS2 (5 documents)

    Export disorders for FARS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FARS2 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with FARS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression and characterization of a human mitochondrial phenylalanyl-tRNA synthetase. (PubMed id 10329163)1, 2, 3, 9 Bullard J.M.... Spremulli L.L. (1999)
    2. Eukaryotic cytosolic and mitochondrial phenylalanyl-tRNA synthetases catalyze the charging of tRNA with the meta-tyrosine. (PubMed id 19549855)1, 2, 9 Klipcan L.... Safro M.G. (2009)
    3. The tRNA-induced conformational activation of human mitochondrial phenylalanyl-tRNA synthetase. (PubMed id 18611382)1, 2, 9 Klipcan L....Safro M. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    6. Large-scale movement of functional domains facilitate s aminoacylation by human mitochondrial phenylalanyl-tRNA synthetase. (PubMed id 19737557)1, 9 Yadavalli S.S....Ibba M. (2009)
    7. Purification, crystallization and preliminary X-ray characterization of a human mitochondrial phenylalanyl-tRNA synthetase. (PubMed id 17768348)1, 9 Levin I....Safro M. (2007)
    8. Mitochondrial aminoacyl-tRNA synthetase single-nucleo tide polymorphisms that lead to defects in refolding but not aminoacylation. (PubMed id 21601574)1 Banerjee R....Ibba M. (2011)
    9. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PubMed id 21998595)1 N'Diaye A....Haiman C.A. (2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10667 HGNC: 21062 AceView: FARS1 Ensembl:ENSG00000145982 euGenes: HUgn10667
    ECgene: FARS2 Kegg: 10667 H-InvDB: FARS2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FARS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FARS2 gene:
    Search GeneIP for patents involving FARS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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