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FARP2 Gene

protein-coding   GIFtS: 60
GCID: GC02P242315

FERM, RhoGEF And Pleckstrin Domain Protein 2

  Search for FARP2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FERM, RhoGEF And Pleckstrin Domain Protein 21 2     PH Domain-Containing Family C Member 32 3
Pleckstrin Homology Domain-Containing Family C Member 32 3     FRG2
FIR2 3     FERM, RhoGEF And Pleckstrin Domain-Containing Protein 22
PLEKHC32 3     FGD1-Related Cdc42-GEF2
FERM Domain Including RhoGEF2 3     KIAA07933

External Ids:    HGNC: 164601   Entrez Gene: 98552   Ensembl: ENSG000000066077   UniProtKB: O948873   

Export aliases for FARP2 gene to outside databases

Previous GC identifers: GC02M239859 GC02P242616 GC02P242015 GC02P234051


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FARP2 Gene:
FARP2 (FERM, RhoGEF and pleckstrin domain protein 2) is a protein-coding gene. GO annotations related to this gene include cytoskeletal protein binding and phospholipid binding. An important paralog of this gene is EPB41L5.

UniProtKB/Swiss-Prot: FARP2_HUMAN, O94887
Function: Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity.
Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in
TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin
cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity)

Gene Wiki entry for FARP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the FARP2 gene promoter:
         c-Fos   AML1a   HOXA3   AP-1   ATF-2   Lmo2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFARP2 promoter sequence
   Search Chromatin IP Primers for FARP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FARP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

FARP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FARP2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P242315:  view genomic region     (about GC identifiers)

Start:
242,295,658 bp from pter      End:
242,434,256 bp from pter
Size:
138,599 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FARP2_HUMAN, O94887 (See protein sequence)
Recommended Name: FERM, RhoGEF and pleckstrin domain-containing protein 2  
Size: 1054 amino acids; 119888 Da
Subunit: Interacts with PLXNA1. Interaction with PLXNA1 or PIP5K1C lowers its guanine nucleotide exchange
activity. Dissociates from PLXNA1 when SEMA3A binds to the receptor. Interacts with PIP5K1C via its FERM domain.
The interaction with PIP5K1C is enhanced by SEMA3A binding. Interacts with RAC1 (By similarity)
Sequence caution: Sequence=BAA34513.2; Type=Erroneous initiation;
Secondary accessions: Q53QM5 Q8WU27 Q9UFE7
Alternative splicing: 2 isoforms:  O94887-1   O94887-2   

Explore the universe of human proteins at neXtProt for FARP2: NX_O94887

Explore proteomics data for FARP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FARP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001269912.1  NP_001269913.1  NP_055623.1  

    ENSEMBL proteins: 
     ENSP00000264042   ENSP00000362384   ENSP00000393376   ENSP00000388167   ENSP00000412772  
     ENSP00000411353   ENSP00000415474   ENSP00000403437   ENSP00000443876  
    Reactome Protein details: O94887

    FARP2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for FARP2

     
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    Search eBioscience for ELISAs for FARP2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    ARHGEF: Rho guanine nucleotide exchange factors

    Selected InterPro protein domains (see all 13):
     IPR019748 FERM_central
     IPR019750 Band_41_fam
     IPR000219 DH-domain
     IPR000798 Ez/rad/moesin_like
     IPR001849 Pleckstrin_homology

    Graphical View of Domain Structure for InterPro Entry O94887

    ProtoNet protein and cluster: O94887

    3 Blocks protein domains:
    IPB000219 DH domain
    IPB000299 Band 4.1 domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: FARP2_HUMAN, O94887
    Domain: Intramolecular interaction between the DH domain and the PH domains can stabilize the protein in an
    autoinhibited conformation (By similarity)
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 FERM domain
    Similarity: Contains 2 PH domains


    Find genes that share domains with FARP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FARP2_HUMAN, O94887
    Function: Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity.
    Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in
    TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin
    cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005089Rho guanyl-nucleotide exchange factor activity IDA12351724
    GO:0008092cytoskeletal protein binding IEA--
    GO:0030676Rac guanyl-nucleotide exchange factor activity ISS--
         
    Find genes that share ontologies with FARP2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FARP2:
     Upregulation of Wnt/beta-caten 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Farp2):
     endocrine/exocrine gland  hematopoietic system  immune system  integument  nervous system 
     skeleton 

    Find genes that share phenotypes with FARP2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Farp2tm1Akum for FARP2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FARP2
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: FARP2 (NM_014808)
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    cytoskeleton2
    nucleus2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA12351724
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IEA--
    GO:0019898extrinsic component of membrane IEA--

    Find genes that share ontologies with FARP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FARP2 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    2Semaphorin interactions
    Semaphorin interactions0.43
    SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion0.00
    3Development Endothelin 1 EDNRA signaling
    Development Endothelin 1 EDNRA signaling0.41
    Cytoskeleton remodeling FAK signaling0.41
    4Focal adhesion
    Focal Adhesion0.65
    5PAK Pathway
    Epithelial Adherens Junctions0.36


    Find genes that share SuperPaths with FARP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for FARP2
        Epithelial Adherens Junctions

    2 GeneGo (Thomson Reuters) Pathways for FARP2
        Development Endothelin-1/EDNRA signaling
    Cytoskeleton remodeling FAK signaling

    3 BioSystems Pathways for FARP2
        Focal Adhesion
    Regulation of CDC42 activity
    Nectin adhesion pathway

    1 Reactome Pathway for FARP2
        SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion


    2 Kegg Pathways  (Kegg details for FARP2):
        Rap1 signaling pathway
    Adherens junction

        Pathway & Disease-focused RT2 Profiler PCR Array including FARP2: 
              Adherens Junctions in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FARP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for FARP2 (O948873 ENSP000002640424) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDZK1Q5T2W13, ENSP000003421434I2D: score=1 STRING: ENSP00000342143
    SRCP129313, ENSP000003509414I2D: score=2 STRING: ENSP00000350941
    YWHAGP619813, ENSP000003063304I2D: score=1 STRING: ENSP00000306330
    CDC42ENSP000003144584STRING: ENSP00000314458
    FYNENSP000003576564STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion ISS--
    GO:0007411axon guidance TAS--
    GO:0016322neuron remodeling IDA12351724
    GO:0016601Rac protein signal transduction IDA12351724
    GO:0030316osteoclast differentiation ISS--

    Find genes that share ontologies with FARP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FARP2

    3 HMDB Compounds for FARP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FARP2 gene (3 alternative transcripts): 
    NM_001282983.1  NM_001282984.1  NM_014808.3  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000264042(uc002wbi.2) ENST00000478489 ENST00000373287(uc010zor.2)
    ENST00000479427 ENST00000492868 ENST00000418082 ENST00000445489 ENST00000464142
    ENST00000473082 ENST00000467260 ENST00000471447 ENST00000485051 ENST00000413432
    ENST00000476799 ENST00000473510 ENST00000422951 ENST00000496470 ENST00000491425

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    Selected AceView cDNA sequences (see all 269):

    BQ632825 BE819663 BU194985 AI685506 BM794719 BU623875 AA286694 AA327689 
    BQ632539 BX117045 BU620971 BP356135 H71153 AB018336 AI308958 AI205691 
    H99851 BM764426 BQ961426 BQ722985 BM910128 BP344770 BX648698 F03310 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FARP2 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20a ·
    SP1:              -                                                                             -     -                             -           -     -         
    SP2:              -                                                                             -     -                             -                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29
    SP1:                    -           -                                             
    SP2:                                                                              
    SP3:                                                                              
    SP4:                                -                                             
    SP5:                                                                              


    ECgene alternative splicing isoforms for FARP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FARP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCTCTAGA
    FARP2 Expression
    About this image


    FARP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells I Spleen
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen
    FARP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FARP2 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Array including FARP2: 
              Adherens Junctions in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FARP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FARP2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Farp21 , 5 FERM, RhoGEF and pleckstrin domain protein 21, 5 83.32(n)1
    83.73(a)1
      1 (47.24 cM)5
    2273771  NM_145519.21  NP_663494.21 
     935120795 
    chicken
    (Gallus gallus)
    Aves FARP21 FERM, RhoGEF and pleckstrin domain protein 2 73.18(n)
    75.12(a)
      424842  XM_004937018.1  XP_004937075.1 
    lizard
    (Anolis carolinensis)
    Reptilia FARP26
    FERM, RhoGEF and pleckstrin domain protein 2
    71(a)
    1 ↔ 1
    3(30299397-30416008)
    zebrafish
    (Danio rerio)
    Actinopterygii wufc23d052 wufc23d05 77.28(n)   324273  BI427858.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cdep1 Cdep 52.77(n)
    45.76(a)
      40608  NM_001043211.2  NP_001036676.1 


    ENSEMBL Gene Tree for FARP2 (if available)
    TreeFam Gene Tree for FARP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FARP2 gene
    EPB41L52  EPB412  FRMD32  EPB41L12  PTPN32  EPB41L4B2  FARP12  PTPN42  
    FRMD52  FRMD72  EPB41L32  EPB41L4A2  EPB41L22  
    15 SIMAP similar genes for FARP2 using alignment to 8 protein entries:     FARP2_HUMAN (see all proteins):
    FRMD7    PTPN4    FARP1    EPB41L3    EPB41L2    EPB41L1
    RDX    MSN    EPB41L4A    EPB41    EPB41L4B    FRMD5
    FRMD3    PTPN21    EPB41L5

    Find genes that share paralogs with FARP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FARP2 (see all 3054)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2008020621,2
    Cuntested1242343336(+) ATACTC/G/TAGTCC 2 Q * stg10--------
    rs1141519491,2
    F--241654929(+) AAATTA/GCTTGA 1 -- int11Minor allele frequency- G:0.03WA 118
    rs1392695071,2
    --242293957(+) ATCCCA/GGGACC 1 -- us2k10--------
    rs1434840151,2
    --242294047(+) TCTCTA/CGTTCC 1 -- us2k10--------
    rs1163177211,2
    F--242294112(+) CACCAG/ACACAC 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs37553951,2
    C--242294116(+) AGCACA/GCACCC 1 -- us2k16Minor allele frequency- G:0.36EA NA WA 1838
    rs621931971,2
    C,F--242294301(+) CATGAG/AGGGAG 1 -- us2k14Minor allele frequency- A:0.11NA EA 244
    rs779553631,2
    F--242294313(+) ATCCCG/ACACAG 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs745668511,2
    F--242294320(+) ACAGCT/AGAGCC 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1462857611,2
    --242294346(+) TGGGTC/TTCAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FARP2 (242295658 - 242434256 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FARP2 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2722001CNV Deletion23290073
    esv2662745CNV Deletion23128226
    esv2721996CNV Deletion23290073
    esv2722002CNV Deletion23290073
    esv2721997CNV Deletion23290073
    esv2721998CNV Deletion23290073
    esv2722004CNV Deletion23290073
    esv2721999CNV Deletion23290073
    esv2722000CNV Deletion23290073
    esv2722003CNV Deletion23290073

    Human Gene Mutation Database (HGMD): FARP2
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing FARP2
    DNA2.0 Custom Variant and Variant Library Synthesis for FARP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease from the University of Copenhagen DISEASES database for FARP2:
    Brachydactyly

    Find genes that share disorders with FARP2           About GenesLikeMe

    Genetic Association Database (GAD): FARP2
    Human Genome Epidemiology (HuGE) Navigator: FARP2 (3 documents)

    Export disorders for FARP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FARP2 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with FARP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    2. Inherited genetic susceptibility to monoclonal B-cell lymphocytosis. (PubMed id 20855867)1, 4 Crowther-Swanepoel D....Houlston R.S. (Blood 2010)
    3. Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk. (PubMed id 20062064)1, 4 Crowther-Swanepoel D....Houlston R.S. (Nat. Genet. 2010)
    4. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PubMed id 20468071)1, 4 Dick D.M....Bierut L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling. (PubMed id 12351724)1, 3 Kubo T....Tohyama M. (J. Neurosci. 2002)
    8. Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. (PubMed id 23770605)1 Berndt S.I....Slager S.L. (Nat. Genet. 2013)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9855 HGNC: 16460 AceView: FARP2 Ensembl:ENSG00000006607 euGenes: HUgn9855
    ECgene: FARP2 Kegg: 9855 H-InvDB: FARP2

    (According to HUGE)
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    HUGE: KIAA0793

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FARP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FARP2 gene:
    Search GeneIP for patents involving FARP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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