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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FARP2 Gene

protein-coding GIFtS: 62
GCID: GC02P242315

FERM, RhoGEF and pleckstrin domain protein 2

Explore 8 diseases affiliated with
FARP2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
FERM, RhoGEF And Pleckstrin Domain Protein 2¹ ²		Pleckstrin Homology Domain-Containing Family C Member 3² ³
FIR¹ ² ³		FERM Domain Including RhoGEF² ³
PLEKHC3¹ ² ³		PH Domain-Containing Family C Member 3² ³
FRG¹ ²		FERM, RhoGEF And Pleckstrin Domain-Containing Protein 2²
KIAA0793¹ ³		FGD1-Related Cdc42-GEF²

External Ids:	HGNC: 16460¹	Entrez Gene: 9855²	Ensembl: ENSG00000006607⁷	UniProtKB: O94887³

Export aliases for FARP2 gene to outside databases

Previous GC identifers: GC02M239859 GC02P242616 GC02P242015 GC02P234051

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: FARP2_HUMAN, O94887

Function: Rho-guanine nucleotide exchange factor that activates RAC1. Plays a role in the response to class 3

semaphorins and remodeling of the actin cytoskeleton (By similarity)

Gene Wiki entry for FARP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005416.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FARP2 gene promoter:
c-Fos AML1a HOXA3 AP-1 ATF-2 Lmo2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FARP2 promoter sequence

Search SABiosciences Chromatin IP Primers for FARP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FARP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3 Ensembl cytogenetic band: 2q37.3 HGNC cytogenetic band: 2q37.3

FARP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FARP2 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P242315: view genomic region (about GC identifiers)

Start:	242,295,658 bp from pter	End:	242,434,256 bp from pter
Size:	138,599 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FARP2_HUMAN, O94887 (See protein sequence)

Recommended Name: FERM, RhoGEF and pleckstrin domain-containing protein 2

Size: 1054 amino acids; 119888 Da

Subunit: Interacts with PLXNA1. Interaction with PLXNA1 or PIP5K1C lowers its guanine nucleotide exchange activity.

Dissociates from PLXNA1 when SEMA3A binds to the receptor. Interacts with PIP5K1C via its FERM domain. The interaction

with PIP5K1C is enhanced by SEMA3A binding (By similarity)

Sequence caution: Sequence=BAA34513.2; Type=Erroneous initiation;

Secondary accessions: Q53QM5 Q8WU27 Q9UFE7

Alternative splicing: 2 isoforms: O94887-1 O94887-2

Explore the universe of human proteins at neXtProt for FARP2: NX_O94887

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O94887

FARP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055623.1

ENSEMBL proteins:

ENSP00000264042 ENSP00000362384 ENSP00000393376 ENSP00000388167 ENSP00000412772

ENSP00000411353 ENSP00000415474 ENSP00000403437 ENSP00000443876

Reactome Protein details: O94887
Human Recombinant Protein Products:

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	GenScript Custom Purified and Recombinant Proteins Services for FARP2
	Novus Biologicals FARP2 Proteins
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for FARP2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	12351724
GO:0005829	cytosol	TAS	--
GO:0005856	cytoskeleton	IEA	--
GO:0019898	extrinsic to membrane	IEA	--

FARP2 for ontologies About GeneDecksing

FARP2 Antibody Products:

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	Novus Biologicals FARP2 Antibodies
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	Search ThermoFisher Antibodies for FARP2

Assay Products for FARP2:

	Browse Kits and Assays available from EMD Millipore
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	Uscn ELISAs and CLIAs for FARP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FARP2 for domains About GeneDecksing

5/13 InterPro domains/families (see all 13):

IPR019748 FERM_central

IPR019750 Band_41_fam

IPR000219 DH-domain

IPR000798 Ez/rad/moesin

IPR001849 Pleckstrin_homology

Graphical View of Domain Structure for InterPro Entry O94887

ProtoNet protein and cluster: O94887

3 Blocks protein families:

IPB000219 DH domain

IPB000299 Band 4.1 domain

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: FARP2_HUMAN, O94887

Similarity: Contains 1 DH (DBL-homology) domain

Similarity: Contains 1 FERM domain

Similarity: Contains 2 PH domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FARP2_HUMAN, O94887

Function: Rho-guanine nucleotide exchange factor that activates RAC1. Plays a role in the response to class 3

semaphorins and remodeling of the actin cytoskeleton (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: FARP2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FARP2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate FARP2
		SwitchGear 3'UTR luciferase reporter plasmid: FARP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FARP2 (see all 6) Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FARP2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for FARP2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: FARP2 (NM_014808)
		Browse Sino Biological Human cDNA Clones
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FARP2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FARP2
		Search LifeMap BioReagents cell lines for FARP2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FARP2

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005089	Rho guanyl-nucleotide exchange factor activity	IDA	12351724
GO:0005543	phospholipid binding	IEA	--
GO:0008092	cytoskeletal protein binding	IEA	--

FARP2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for FARP2:

Upregulation of Wnt/beta-caten

Animal Models:
Mouse knock-out Farp2^tm1Akum for FARP2
5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Farp2):

hematopoietic system

immune system

integument

nervous system

skeleton

FARP2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development_Endothelin-1/EDNRA transactivation of EGFR

	Development Endothelin-1/EDNRA signaling	0.41			Cytoskeleton remodeling_FAK signaling	0.41
	Development_Endothelin-1/EDNRA signaling	0.41			Cytoskeleton remodeling FAK signaling	0.41

Axon guidance

Axon guidance

1.00

Developmental Biology

0.69

SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

1.00

Focal Adhesion

Focal Adhesion

1.00

Nectin adhesion pathway

Nectin adhesion pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for FARP2

	Cytoskeleton remodeling FAK signaling
	Development Endothelin-1/EDNRA signaling

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for FARP2

Epithelial Adherens Junctions

2 GeneGo (Thomson Reuters) Pathways for FARP2

	Development Endothelin-1/EDNRA signaling
	Cytoskeleton remodeling FAK signaling

3 BioSystems Pathways for FARP2

	Focal Adhesion
	Regulation of CDC42 activity
	Nectin adhesion pathway

4 Reactome Pathways for FARP2

	Developmental Biology
	Semaphorin interactions
	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
	Axon guidance

1 Kegg Pathway (Kegg details for FARP2):

Adherens junction

FARP2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FARP2

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

5/16 Interacting proteins for FARP2 (O94887³ ENSP00000264042⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 16)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PDZK1	Q5T2W1³, ENSP00000342143⁴	I2D: score=1 STRING: ENSP00000342143
SRC	P12931³, ENSP00000350941⁴	I2D: score=2 STRING: ENSP00000350941
YWHAG	P61981³, ENSP00000306330⁴	I2D: score=1 STRING: ENSP00000306330
CDC42	ENSP00000314458⁴	STRING: ENSP00000314458
FYN	ENSP00000357656⁴	STRING: ENSP00000357656

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007411	axon guidance	TAS	--
GO:0016322	neuron remodeling	IDA	12351724
GO:0016601	Rac protein signal transduction	IDA	12351724
GO:0035023	regulation of Rho protein signal transduction	IEA	--

FARP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FARP2

3 HMDB Compounds for FARP2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about FARP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FARP2 gene:

NM_014808.2

Unigene Cluster for FARP2:

FERM, RhoGEF and pleckstrin domain protein 2

Hs.726316 [show with all ESTs]

Unigene Representative Sequence: NM_014808

18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):

ENST00000264042(uc002wbi.2) ENST00000478489 ENST00000373287(uc010zor.2)

ENST00000479427 ENST00000492868 ENST00000418082 ENST00000445489 ENST00000464142

ENST00000473082 ENST00000467260 ENST00000471447 ENST00000485051 ENST00000413432

ENST00000476799 ENST00000473510 ENST00000422951 ENST00000496470 ENST00000491425

miRNA Products:		OriGene 3'-UTR Clone: FARP2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FARP2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate FARP2
		SwitchGear 3'UTR luciferase reporter plasmid: FARP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FARP2 (see all 6) Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FARP2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FARP2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FARP2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FARP2 (NM_014808)
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FARP2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FARP2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FARP2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FARP2

Additional cDNA sequence:

AB018336.1 AK124871.1 AK127510.1 AK300435.1 AL122052.1 BC021301.2

21 DOTS entries:

DT.100881864 DT.451907 DT.75146601 DT.40120139 DT.95158444 DT.120933002 DT.453162 DT.97835833

DT.91998161 DT.120933089 DT.40258260 DT.120933015 DT.95131292 DT.95226615 DT.97825438 DT.120932976

DT.86845792 DT.91960965 DT.92001512 DT.95154735 DT.99999966

24/269 AceView cDNA sequences (see all 269):

BU620971 H71153 BX117045 AB018336 BP356135 AI308958 H99851 AI205691

BM764426 BQ961426 BQ722985 BM910128 BX648698 BP344770 AA714660 CB267637

F03310 BU187010 AI061318 AW131062 BE049624 BE327873 BX111490 AA629387

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for FARP2 (see all 9) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14a	·	14b	^	15a	·	15b	^	16	^	17a	·	17b	^	18a	·	18b	^	19a	·	19b	^	20a	·
SP1:					-																										-		-										-				-		-
SP2:					-																										-		-										-
SP3:
SP4:
SP5:

ExUns:	20b	^	21	^	22	^	23a	·	23b	^	24a	·	24b	^	25	^	26a	·	26b	^	27	^	28	^	29
SP1:							-				-
SP2:
SP3:
SP4:											-
SP5:

ECgene alternative splicing isoforms for FARP2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FARP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACCTCTAGA

About this image

FARP2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Mandibular Fossa

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FARP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FARP2

SOURCE GeneReport for Unigene cluster: Hs.726316

SABiosciences Expression via Pathway-Focused PCR Array including FARP2:

Adherens Junctions in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FARP2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FARP2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FARP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FARP2 gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FARP2¹	FERM, RhoGEF and pleckstrin domain protein 2	74.95(n) 78.63(a)		424842 XM_422653.3 XP_422653.3
lizard (Anolis carolinensis)	Reptilia	FARP2⁶	--	71(a)	1 ↔ 1	3(30332174-30412013)
zebrafish (Danio rerio)	Actinopterygii	wufc23d05²	wufc23d05	77.28(n)		324273 BI427858.1
fruit fly (Drosophila melanogaster)	Insecta	Cdep¹	CG31536-PC	51.72(n) 44.22(a)		40608 NM_001043211.1 NP_001036676.1
worm (Caenorhabditis elegans)	Secernentea	frm-3⁶	FERM domain (protein4.1-ezrin-radixin-moesin) fami...	21(a)	1 → many	X(11576180-11580873)

ENSEMBL Gene Tree for FARP2 (if available)
TreeFam Gene Tree for FARP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FARP2 gene

EPB41² EPB41L5² FRMD3² EPB41L1² EPB41L4B² FARP1² FRMD5² MYLIP²

EPB41L3² FRMD7² EPB41L4A² EPB41L2²

15 SIMAP similar genes for FARP2 using alignment to 8 protein entries: FARP2_HUMAN (see all proteins):

FRMD7 FARP1 PTPN4 EPB41L3 EPB41L2 EPB41L1

RDX MSN EPB41L4A EPB41 EPB41L4B FRMD5

FRMD3 PTPN21 EPB41L5

FARP2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs200802062^1,2	C,	other	242343336(+)	`ATACTC/G/TAGTCC`	3	Q E *	mis¹ stg¹		0	--	--	--	--
rs139269507^1,2		--	242293957(+)	`ATCCCA/GGGACC`	1	--	us2k¹		0	--	--	--	--
rs143484015^1,2		--	242294047(+)	`TCTCTA/CGTTCC`	1	--	us2k¹		0	--	--	--	--
rs116317721^1,2	F,	--	242294112(+)	`CACCAG/ACACAC`	1	--	us2k¹		1		WA	118
rs3755395^1,2	C,	--	242294116(+)	`AGCACA/GCACCC`	1	--	us2k¹		6		EA NA WA	1838
rs62193197^1,2	C,F,	--	242294301(+)	`CATGAG/AGGGAG`	1	--	us2k¹		4		NA EA	244
rs77955363^1,2	F,	--	242294313(+)	`ATCCCG/ACACAG`	1	--	us2k¹		1		NA	120
rs74566851^1,2	F,	--	242294320(+)	`ACAGCT/AGAGCC`	1	--	us2k¹		1		WA	118
rs146285761^1,2		--	242294346(+)	`TGGGTC/TTCAGA`	1	--	us2k¹		0	--	--	--	--
rs3755396^1,2	C,F,H	--	242294396(+)	`CCAGCA/CTTTCT`	1	--	us2k¹		3		EA NS NA	1648

HapMap Linkage Disequilibrium report for FARP2 (242295658 - 242434256 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for FARP2
3 CNVs: 90412 3410 63353
Human Gene Mutation Database (HGMD): FARP2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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FARP2 for disorders About GeneDecksing

8 diseases for FARP2: About MalaCards

aarskog-scott syndrome scott syndrome conduct disorder chronic lymphocytic leukemia

lymphocytic leukemia brachydactyly leukemia neuronitis

1 disease from the University of Copenhagen DISEASES database for FARP2:

Brachydactyly

Human Genome Epidemiology (HuGE) Navigator: FARP2 (3 documents)

Export disorders for FARP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for FARP2 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with FARP2)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)^{1, 2, 3} Nagase T.... Ohara O. (1998)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling. (PubMed id 12351724)^{1, 3} Kubo T....Tohyama M. (2002)
Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia. (PubMed id 22700719)¹ Slager S.L....Houlston R.S. (2012)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Inherited genetic susceptibility to monoclonal B-cell lymphocytosis. (PubMed id 20855867)¹ Crowther-Swanepoel D....Houlston R.S. (2010)
Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24 .1 influence chronic lymphocytic leukemia risk. (PubMed id 20062064)¹ Crowther-Swanepoel D....Houlston R.S. (2010)
Evidence for genes on chromosome 2 contributing to al cohol dependence with conduct disorder and suicide attempts. (PubMed id 20468071)¹ Dick D.M....Bierut L. (2010)
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)² Mayya V.... Han D.K. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9855	HGNC: 16460	AceView: FARP2	Ensembl:ENSG00000006607	euGenes: HUgn9855
ECgene: FARP2	Kegg: 9855	H-InvDB: FARP2

(According to HUGE)
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HUGE: KIAA0793

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FARP2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FARP2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for FARP2 gene:
Search GeneIP for patents involving FARP2

GeneCards and IP:
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FERM, RhoGEF and pleckstrin domain protein 2

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FERM, RhoGEF and pleckstrin domain protein 2

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