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Aliases for FARP2 Gene

Aliases for FARP2 Gene

  • FERM, ARH/RhoGEF And Pleckstrin Domain Protein 2 2 3 5
  • Pleckstrin Homology Domain-Containing Family C Member 3 3 4
  • FERM, RhoGEF And Pleckstrin Domain Protein 2 2 3
  • PH Domain-Containing Family C Member 3 3 4
  • FERM Domain Including RhoGEF 3 4
  • PLEKHC3 3 4
  • FIR 3 4
  • FERM, RhoGEF And Pleckstrin Domain-Containing Protein 2 3
  • FGD1-Related Cdc42-GEF 3
  • KIAA0793 4
  • FRG 3

External Ids for FARP2 Gene

Previous GeneCards Identifiers for FARP2 Gene

  • GC02M239859
  • GC02P242315
  • GC02P242616
  • GC02P242015
  • GC02P234051

Summaries for FARP2 Gene

GeneCards Summary for FARP2 Gene

FARP2 (FERM, ARH/RhoGEF And Pleckstrin Domain Protein 2) is a Protein Coding gene. Diseases associated with FARP2 include Pseudohypoparathyroidism Ia. Among its related pathways are Development Endothelin-1/EDNRA signaling and PAK Pathway. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity and Rac guanyl-nucleotide exchange factor activity. An important paralog of this gene is FARP1.

UniProtKB/Swiss-Prot for FARP2 Gene

  • Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity).

Gene Wiki entry for FARP2 Gene

Additional gene information for FARP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FARP2 Gene

Genomics for FARP2 Gene

Regulatory Elements for FARP2 Gene

Enhancers for FARP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H241616 1.2 ENCODE dbSUPER 44.2 +262.8 262764 4 HDGF PKNOX1 GLI4 YY1 ETS1 ZNF143 FOS SP3 YY2 REST ENSG00000223374 ING5 SNED1 ENSG00000235351 MTERF4 FARP2 BOK D2HGDH DTYMK SEPT2
GH02H241313 1.4 ENCODE dbSUPER 25 -40.2 -40190 4 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SEPT2 ANKMY1 FARP2 MTERF4 HDLBP ING5 ATG4B ENSG00000235351 ANO7 ENSG00000223374
GH02H241543 1.3 Ensembl ENCODE 22.5 +190.0 189959 4 HDGF PKNOX1 ZNF133 ARID4B YBX1 ZNF2 ZNF121 ZNF766 FOS ZNF548 ENSG00000223374 MTERF4 ATG4B ANKMY1 ING5 CAPN10 FARP2 SNED1 D2HGDH DTYMK
GH02H241311 1.3 Ensembl ENCODE dbSUPER 16 -44.0 -43983 1 HDGF FOXA2 BATF FOSL1 GATA3 EED SCRT2 ZNF600 ATF7 IKZF2 SEPT2 FARP2 LOC101927509
GH02H241354 1.3 ENCODE dbSUPER 15.5 +1.1 1127 5 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF143 PAF1 SP3 MXD4 NFYC SEPT2 HDLBP FARP2 ANO7 LOC105373973
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FARP2 on UCSC Golden Path with GeneCards custom track

Promoters for FARP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000133268 157 2001 HDGF PKNOX1 ARID4B SIN3A DMAP1 GLIS2 ZNF143 PAF1 SP3 MXD4

Genomic Location for FARP2 Gene

Chromosome:
2
Start:
241,356,243 bp from pter
End:
241,494,842 bp from pter
Size:
138,600 bases
Orientation:
Plus strand

Genomic View for FARP2 Gene

Genes around FARP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FARP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FARP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FARP2 Gene

Proteins for FARP2 Gene

  • Protein details for FARP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94887-FARP2_HUMAN
    Recommended name:
    FERM, RhoGEF and pleckstrin domain-containing protein 2
    Protein Accession:
    O94887
    Secondary Accessions:
    • B7Z6J8
    • F5GZ84
    • Q53QM5
    • Q8WU27
    • Q9UFE7

    Protein attributes for FARP2 Gene

    Size:
    1054 amino acids
    Molecular mass:
    119888 Da
    Quaternary structure:
    • Interacts with PLXNA1. Interaction with PLXNA1 or PIP5K1C lowers its guanine nucleotide exchange activity. Dissociates from PLXNA1 when SEMA3A binds to the receptor. Interacts with PIP5K1C via its FERM domain. The interaction with PIP5K1C is enhanced by SEMA3A binding. Interacts with RAC1 (By similarity).
    SequenceCaution:
    • Sequence=BAA34513.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FARP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FARP2 Gene

Post-translational modifications for FARP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FARP2 Gene

Domains & Families for FARP2 Gene

Suggested Antigen Peptide Sequences for FARP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94887

UniProtKB/Swiss-Prot:

FARP2_HUMAN :
  • Intramolecular interaction between the DH domain and the PH domains can stabilize the protein in an autoinhibited conformation.
Domain:
  • Intramolecular interaction between the DH domain and the PH domains can stabilize the protein in an autoinhibited conformation.
genes like me logo Genes that share domains with FARP2: view

Function for FARP2 Gene

Molecular function for FARP2 Gene

UniProtKB/Swiss-Prot Function:
Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity).

Phenotypes From GWAS Catalog for FARP2 Gene

Gene Ontology (GO) - Molecular Function for FARP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA,IDA 12351724
GO:0008092 cytoskeletal protein binding IEA --
GO:0030676 Rac guanyl-nucleotide exchange factor activity ISS --
genes like me logo Genes that share ontologies with FARP2: view
genes like me logo Genes that share phenotypes with FARP2: view

Animal Models for FARP2 Gene

MGI Knock Outs for FARP2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FARP2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FARP2 Gene

Localization for FARP2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FARP2 gene
Compartment Confidence
cytosol 5
cytoskeleton 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FARP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12351724
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with FARP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FARP2 Gene

Pathways & Interactions for FARP2 Gene

genes like me logo Genes that share pathways with FARP2: view

Pathways by source for FARP2 Gene

Gene Ontology (GO) - Biological Process for FARP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion ISS --
GO:0016322 neuron remodeling IDA 12351724
GO:0016601 Rac protein signal transduction IDA 12351724
GO:0022405 hair cycle process IEA --
GO:0030316 osteoclast differentiation ISS --
genes like me logo Genes that share ontologies with FARP2: view

No data available for SIGNOR curated interactions for FARP2 Gene

Drugs & Compounds for FARP2 Gene

(3) Drugs for FARP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with FARP2: view

Transcripts for FARP2 Gene

mRNA/cDNA for FARP2 Gene

Unigene Clusters for FARP2 Gene

FERM, RhoGEF and pleckstrin domain protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FARP2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FARP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20a ·
SP1: - - - - - -
SP2: - - - -
SP3:
SP4:
SP5:
SP6: - -
SP7:
SP8:
SP9: - -

ExUns: 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29
SP1: - -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for FARP2 Gene

GeneLoc Exon Structure for
FARP2
ECgene alternative splicing isoforms for
FARP2

Expression for FARP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FARP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FARP2 Gene

This gene is overexpressed in Synovial fluid (67.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FARP2 Gene



NURSA nuclear receptor signaling pathways regulating expression of FARP2 Gene:

FARP2

SOURCE GeneReport for Unigene cluster for FARP2 Gene:

Hs.726316

Evidence on tissue expression from TISSUES for FARP2 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with FARP2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FARP2 Gene

Orthologs for FARP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FARP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FARP2 33 34
  • 96.71 (n)
mouse
(Mus musculus)
Mammalia Farp2 16 34 33
  • 83.32 (n)
dog
(Canis familiaris)
Mammalia FARP2 34 33
  • 82.83 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Farp2 33
  • 82.55 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FARP2 34
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FARP2 34
  • 72 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FARP2 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves FARP2 33 34
  • 73.18 (n)
lizard
(Anolis carolinensis)
Reptilia FARP2 34
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii farp2 34 33
  • 67.77 (n)
OneToOne
wufc23d05 33
fruit fly
(Drosophila melanogaster)
Insecta Cdep 33 34
  • 52.77 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001287 33
  • 52.61 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8849 34
  • 44 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3850 33
Species where no ortholog for FARP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FARP2 Gene

ENSEMBL:
Gene Tree for FARP2 (if available)
TreeFam:
Gene Tree for FARP2 (if available)

Paralogs for FARP2 Gene

Paralogs for FARP2 Gene

genes like me logo Genes that share paralogs with FARP2: view

Variants for FARP2 Gene

Sequence variations from dbSNP and Humsavar for FARP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000052552 -- 241,447,150(+) TTAAA(C/T)GGGCT intron-variant
rs1000060315 -- 241,380,163(+) CCATG(A/G)CAGTG intron-variant
rs1000061793 -- 241,470,009(+) CCAGT(C/T)GATGA intron-variant
rs1000072468 -- 241,370,667(+) TTCAT(A/G)TATCT intron-variant, upstream-variant-2KB
rs1000084117 -- 241,488,409(+) TTTAC(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FARP2 Gene

Variant ID Type Subtype PubMed ID
esv25720 CNV loss 19812545
esv2662745 CNV deletion 23128226
esv2721996 CNV deletion 23290073
esv2721997 CNV deletion 23290073
esv2721998 CNV deletion 23290073
esv2721999 CNV deletion 23290073
esv2722000 CNV deletion 23290073
esv2722001 CNV deletion 23290073
esv2722002 CNV deletion 23290073
esv2722003 CNV deletion 23290073
esv2722004 CNV deletion 23290073
esv2759120 CNV loss 17122850
esv3326782 CNV insertion 20981092
esv3561309 CNV deletion 23714750
esv3594828 CNV gain 21293372
esv3594830 CNV gain 21293372
esv3594832 CNV gain 21293372
esv3594833 CNV gain 21293372
nsv1112343 CNV deletion 24896259
nsv3244 CNV deletion 18451855

Variation tolerance for FARP2 Gene

Residual Variation Intolerance Score: 98.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.70; 86.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FARP2 Gene

Human Gene Mutation Database (HGMD)
FARP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FARP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FARP2 Gene

Disorders for FARP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FARP2 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
pseudohypoparathyroidism ia
  • albright's hereditary osteodystrophy
- elite association - COSMIC cancer census association via MalaCards
Search FARP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FARP2

Genetic Association Database (GAD)
FARP2
Human Genome Epidemiology (HuGE) Navigator
FARP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FARP2
genes like me logo Genes that share disorders with FARP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FARP2 Gene

Publications for FARP2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 60
  2. Inherited genetic susceptibility to monoclonal B-cell lymphocytosis. (PMID: 20855867) Crowther-Swanepoel D … Houlston RS (Blood 2010) 3 45 60
  3. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PMID: 20468071) Dick DM … Bierut L (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 45 60
  4. Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk. (PMID: 20062064) Crowther-Swanepoel D … Houlston RS (Nature genetics 2010) 3 45 60
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 60

Products for FARP2 Gene

Sources for FARP2 Gene

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