Aliases for FARP2 Gene
Aliases for FARP2 Gene
External Ids for FARP2 Gene
- HGNC: 16460
- Entrez Gene: 9855
- Ensembl: ENSG00000006607
- UniProtKB: O94887
Previous GeneCards Identifiers for FARP2 Gene
- GC02M239859
- GC02P242315
- GC02P242616
- GC02P242015
- GC02P234051
Summaries for FARP2 Gene
GeneCards Summary for FARP2 Gene
FARP2 (FERM, ARH/RhoGEF And Pleckstrin Domain Protein 2) is a Protein Coding gene. Diseases associated with FARP2 include Pseudohypoparathyroidism Ia and Aarskog-Scott Syndrome. Among its related pathways are Development Endothelin-1/EDNRA signaling and Focal Adhesion. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity and Rac guanyl-nucleotide exchange factor activity. An important paralog of this gene is FARP1.
UniProtKB/Swiss-Prot for FARP2 Gene
-
Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FARP2 Gene
Genomics for FARP2 Gene
Regulatory Elements for FARP2 Gene
Enhancers for FARP2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FARP2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FARP2 gene promoter:
Regulatory Element Products
Genomic Location for FARP2 Gene
- Chromosome:
- 2
- Start:
- 241,356,243 bp from pter
- End:
- 241,494,842 bp from pter
- Size:
- 138,600 bases
- Orientation:
- Plus strand
Genomic View for FARP2 Gene
Genes around FARP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q37.3 by Ensembl
- 2q37.3 by Entrez Gene
- 2q37.3 by HGNC
FARP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FARP2 Gene
Proteins for FARP2 Gene
-
Protein details for FARP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O94887-FARP2_HUMAN
- Recommended name:
- FERM, RhoGEF and pleckstrin domain-containing protein 2
- Protein Accession:
- O94887
- B7Z6J8
- F5GZ84
- Q53QM5
- Q8WU27
- Q9UFE7
Protein attributes for FARP2 Gene
- Size:
- 1054 amino acids
- Molecular mass:
- 119888 Da
- Quaternary structure:
-
- Interacts with PLXNA1. Interaction with PLXNA1 or PIP5K1C lowers its guanine nucleotide exchange activity. Dissociates from PLXNA1 when SEMA3A binds to the receptor. Interacts with PIP5K1C via its FERM domain. The interaction with PIP5K1C is enhanced by SEMA3A binding. Interacts with RAC1 (By similarity).
- SequenceCaution:
-
- Sequence=BAA34513.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for FARP2 Gene
Post-translational modifications for FARP2 Gene
Other Protein References for FARP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FARP2
- Invitrogen Antibodies for FARP2
- antibodies-online Antibodies for FARP2: See all 40
- Search GeneTex for Antibodies for FARP2
-
Santa Cruz Biotechnology (SCBT) Antibodies for FARP2
Protein Products
-
OriGene Purified Proteins for FARP2
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- Novus Biologicals proteins for FARP2
- antibodies-online Proteins for FARP2: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FARP2
Assay Products
- antibodies-online Kits for FARP2: See all 3
No data available for DME Specific Peptides for FARP2 Gene
Domains & Families for FARP2 Gene
Gene Families for FARP2 Gene
Protein Domains for FARP2 Gene
Suggested Antigen Peptide Sequences for FARP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O94887UniProtKB/Swiss-Prot:
FARP2_HUMAN :- Intramolecular interaction between the DH domain and the PH domains can stabilize the protein in an autoinhibited conformation.
- Domain:
-
- Intramolecular interaction between the DH domain and the PH domains can stabilize the protein in an autoinhibited conformation.
Function for FARP2 Gene
Molecular function for FARP2 Gene
- UniProtKB/Swiss-Prot Function:
- Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | IEA,IDA | 12351724 |
| GO:0008092 | cytoskeletal protein binding | IEA | -- |
| GO:0030676 | Rac guanyl-nucleotide exchange factor activity | ISS | -- |
Phenotypes for FARP2 Gene
- MGI mutant phenotypes for FARP2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for FARP2:
Animal Model Products
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-
ViGene Biosciences lentiviral particle packaged cDNA for FARP2 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for FARP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FARP2
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miRNA Products
- Search ViGene Biosciences for FARP2
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for FARP2 gene
Cell Line Products
-
Horizon Cell Lines for FARP2
-
ViGene Biosciences adenoviral particle packaged cDNA for FARP2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FARP2 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FARP2 Gene
Localization for FARP2 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| cytoskeleton | 2 |
| nucleus | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | 12351724 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0019898 | extrinsic component of membrane | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for FARP2 Gene
Pathways & Interactions for FARP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Developmental Biology |
.51
|
|
| 2 | Semaphorin interactions | ||
| 3 | Development Endothelin-1/EDNRA signaling | ||
| 4 | Adherens junction | ||
| 5 | Ras signaling pathway | ||
Pathways by source for FARP2 Gene
3 BioSystems pathways for FARP2 Gene
4 Reactome pathways for FARP2 Gene
2 KEGG pathways for FARP2 Gene
2 GeneGo (Thomson Reuters) pathways for FARP2 Gene
1 Qiagen pathway for FARP2 Gene
Interacting Proteins for FARP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007155 | cell adhesion | ISS | -- |
| GO:0016322 | neuron remodeling | IDA | 12351724 |
| GO:0016601 | Rac protein signal transduction | IDA | 12351724 |
| GO:0022405 | hair cycle process | IEA | -- |
| GO:0030316 | osteoclast differentiation | ISS | -- |
No data available for SIGNOR curated interactions for FARP2 Gene
Transcripts for FARP2 Gene
mRNA/cDNA for FARP2 Gene
- (13) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (8) Selected AceView cDNA sequences:
- (23) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FARP2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FARP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FARP2
- GenScript: Design CRISPR guide RNA sequences for FARP2
miRNA Products
- Search ViGene Biosciences for FARP2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FARP2
- Browse OriGene Inhibitory RNA Products For FARP2
-
ViGene Biosciences ready-to-package AAV shRNAs for FARP2 gene
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - |
| ExUns: | 20b | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | ^ | 24a | · | 24b | ^ | 25 | ^ | 26a | · | 26b | ^ | 27 | ^ | 28 | ^ | 29 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||
| SP9: |
Expression for FARP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Synovial fluid (67.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FARP2 Gene
NURSA nuclear receptor signaling pathways regulating expression of FARP2 Gene:
FARP2SOURCE GeneReport for Unigene cluster for FARP2 Gene:
Hs.726316Evidence on tissue expression from TISSUES for FARP2 Gene
- Nervous system(4.7)
Primer Products
-
OriGene qPCR primer pairs for FARP2
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FARP2 Gene
Orthologs for FARP2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FARP2 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Farp2 34 16 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FARP2 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Farp2 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FARP2 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | FARP2 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | FARP2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FARP2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FARP2 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | farp2 34 35 |
|
||
| wufc23d05 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Cdep 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001287 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.8849 35 |
|
OneToMany | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.3850 34 |
|
- Species where no ortholog for FARP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FARP2 Gene
(15) SIMAP similar genes for FARP2 Gene using alignment to 8 proteins:
Variants for FARP2 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000052552 | -- | 241,447,150(+) | TTAAA(C/T)GGGCT | intron-variant | |
| rs1000060315 | -- | 241,380,163(+) | CCATG(A/G)CAGTG | intron-variant | |
| rs1000061793 | -- | 241,470,009(+) | CCAGT(C/T)GATGA | intron-variant | |
| rs1000072468 | -- | 241,370,667(+) | TTCAT(A/G)TATCT | intron-variant, upstream-variant-2KB | |
| rs1000084117 | -- | 241,488,409(+) | TTTAC(-/T)TTTTT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv25720 | CNV | loss | 19812545 |
| esv2662745 | CNV | deletion | 23128226 |
| esv2721996 | CNV | deletion | 23290073 |
| esv2721997 | CNV | deletion | 23290073 |
| esv2721998 | CNV | deletion | 23290073 |
| esv2721999 | CNV | deletion | 23290073 |
| esv2722000 | CNV | deletion | 23290073 |
| esv2722001 | CNV | deletion | 23290073 |
| esv2722002 | CNV | deletion | 23290073 |
| esv2722003 | CNV | deletion | 23290073 |
| esv2722004 | CNV | deletion | 23290073 |
| esv2759120 | CNV | loss | 17122850 |
| esv3326782 | CNV | insertion | 20981092 |
| esv3561309 | CNV | deletion | 23714750 |
| esv3594828 | CNV | gain | 21293372 |
| esv3594830 | CNV | gain | 21293372 |
| esv3594832 | CNV | gain | 21293372 |
| esv3594833 | CNV | gain | 21293372 |
| nsv1112343 | CNV | deletion | 24896259 |
| nsv3244 | CNV | deletion | 18451855 |
Residual Variation Intolerance Score:
98.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.70;
86.51% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FARP2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FARP2 Gene
Disorders for FARP2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pseudohypoparathyroidism ia |
|
|
| aarskog-scott syndrome |
|
|
| scott syndrome |
|
|
Search FARP2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for FARP2
No data available for UniProtKB/Swiss-Prot and Genatlas for FARP2 Gene
Publications for FARP2 Gene
- Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
- Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk. (PMID: 20062064) Crowther-Swanepoel D. … Houlston R.S. (Nat. Genet. 2010) 3 46 64
- Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PMID: 20468071) Dick D.M. … Bierut L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
- Inherited genetic susceptibility to monoclonal B-cell lymphocytosis. (PMID: 20855867) Crowther-Swanepoel D. … Houlston R.S. (Blood 2010) 3 46 64
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
Products for FARP2 Gene
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- Novus Biologicals Antibodies for FARP2
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- antibodies-online Antibodies for FARP2: See all 40
- antibodies-online Kits for FARP2: See all 3
- antibodies-online Proteins for FARP2: See all 4
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- ViGene Biosciences adenoviral particle packaged cDNA for FARP2 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for FARP2
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FARP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
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- (112) GeneTex
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- (128) Genetics Home Reference
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- (130) MedlinePlus
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- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer