Aliases for FARP2 Gene
External Ids for FARP2 Gene
Previous GeneCards Identifiers for FARP2 Gene
GeneCards Summary for FARP2 Gene
FARP2 (FERM, ARH/RhoGEF And Pleckstrin Domain Protein 2) is a Protein Coding gene. Diseases associated with FARP2 include Pseudohypoparathyroidism Ia and Aarskog-Scott Syndrome. Among its related pathways are Development Endothelin-1/EDNRA signaling and Focal Adhesion. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity and Rac guanyl-nucleotide exchange factor activity. An important paralog of this gene is FARP1.
UniProtKB/Swiss-Prot for FARP2 Gene
Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity).