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Aliases for FARP2 Gene

Aliases for FARP2 Gene

  • FERM, ARH/RhoGEF And Pleckstrin Domain Protein 2 2 3 5
  • Pleckstrin Homology Domain-Containing Family C Member 3 3 4
  • FERM, RhoGEF And Pleckstrin Domain Protein 2 2 3
  • PH Domain-Containing Family C Member 3 3 4
  • FERM Domain Including RhoGEF 3 4
  • PLEKHC3 3 4
  • FIR 3 4
  • FGD1-Related Cdc42-GEF 3
  • KIAA0793 4
  • FRG 3

External Ids for FARP2 Gene

Previous GeneCards Identifiers for FARP2 Gene

  • GC02M239859
  • GC02P242315
  • GC02P242616
  • GC02P242015
  • GC02P234051

Summaries for FARP2 Gene

GeneCards Summary for FARP2 Gene

FARP2 (FERM, ARH/RhoGEF And Pleckstrin Domain Protein 2) is a Protein Coding gene. Diseases associated with FARP2 include verheij syndrome and aarskog-scott syndrome. Among its related pathways are Adherens junction and Ras signaling pathway. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity and Rac guanyl-nucleotide exchange factor activity. An important paralog of this gene is FRMD3.

UniProtKB/Swiss-Prot for FARP2 Gene

  • Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity).

Gene Wiki entry for FARP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FARP2 Gene

Genomics for FARP2 Gene

Regulatory Elements for FARP2 Gene

Enhancers for FARP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FARP2 on UCSC Golden Path with GeneCards custom track

Promoters for FARP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FARP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FARP2 Gene

Chromosome:
2
Start:
241,356,243 bp from pter
End:
241,494,842 bp from pter
Size:
138,600 bases
Orientation:
Plus strand

Genomic View for FARP2 Gene

Genes around FARP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FARP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FARP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FARP2 Gene

Proteins for FARP2 Gene

  • Protein details for FARP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94887-FARP2_HUMAN
    Recommended name:
    FERM, RhoGEF and pleckstrin domain-containing protein 2
    Protein Accession:
    O94887
    Secondary Accessions:
    • B7Z6J8
    • F5GZ84
    • Q53QM5
    • Q8WU27
    • Q9UFE7

    Protein attributes for FARP2 Gene

    Size:
    1054 amino acids
    Molecular mass:
    119888 Da
    Quaternary structure:
    • Interacts with PLXNA1. Interaction with PLXNA1 or PIP5K1C lowers its guanine nucleotide exchange activity. Dissociates from PLXNA1 when SEMA3A binds to the receptor. Interacts with PIP5K1C via its FERM domain. The interaction with PIP5K1C is enhanced by SEMA3A binding. Interacts with RAC1 (By similarity).
    SequenceCaution:
    • Sequence=BAA34513.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FARP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FARP2 Gene

Proteomics data for FARP2 Gene at MOPED

Post-translational modifications for FARP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FARP2 Gene

Domains & Families for FARP2 Gene

Suggested Antigen Peptide Sequences for FARP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94887

UniProtKB/Swiss-Prot:

FARP2_HUMAN :
  • Intramolecular interaction between the DH domain and the PH domains can stabilize the protein in an autoinhibited conformation.
Domain:
  • Intramolecular interaction between the DH domain and the PH domains can stabilize the protein in an autoinhibited conformation.
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 FERM domain.
  • Contains 2 PH domains.
genes like me logo Genes that share domains with FARP2: view

Function for FARP2 Gene

Molecular function for FARP2 Gene

UniProtKB/Swiss-Prot Function:
Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity).
genes like me logo Genes that share phenotypes with FARP2: view

Animal Models for FARP2 Gene

MGI Knock Outs for FARP2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FARP2 Gene

Localization for FARP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FARP2 Gene COMPARTMENTS Subcellular localization image for FARP2 gene
Compartment Confidence
cytosol 5
cytoskeleton 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FARP2 Gene

Pathways & Interactions for FARP2 Gene

genes like me logo Genes that share pathways with FARP2: view

Pathways by source for FARP2 Gene

Gene Ontology (GO) - Biological Process for FARP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion ISS --
GO:0007411 axon guidance TAS --
GO:0016601 Rac protein signal transduction IDA 12351724
GO:0031532 actin cytoskeleton reorganization ISS --
GO:0033623 regulation of integrin activation ISS --
genes like me logo Genes that share ontologies with FARP2: view

No data available for SIGNOR curated interactions for FARP2 Gene

Drugs & Compounds for FARP2 Gene

(3) Drugs for FARP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with FARP2: view

Transcripts for FARP2 Gene

Unigene Clusters for FARP2 Gene

FERM, RhoGEF and pleckstrin domain protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FARP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20a ·
SP1: - - - - - -
SP2: - - - -
SP3:
SP4:
SP5:
SP6: - -
SP7:
SP8:
SP9: - -

ExUns: 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29
SP1: - -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for FARP2 Gene

GeneLoc Exon Structure for
FARP2
ECgene alternative splicing isoforms for
FARP2

Expression for FARP2 Gene

mRNA expression in normal human tissues for FARP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FARP2 Gene

This gene is overexpressed in Synovial fluid (67.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FARP2 Gene



SOURCE GeneReport for Unigene cluster for FARP2 Gene Hs.726316

genes like me logo Genes that share expression patterns with FARP2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FARP2 Gene

Orthologs for FARP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FARP2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia FARP2 35
  • 82.83 (n)
  • 80.95 (a)
FARP2 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Farp2 35
  • 83.32 (n)
  • 83.73 (a)
Farp2 16
Farp2 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FARP2 35
  • 96.71 (n)
  • 95.07 (a)
FARP2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Farp2 35
  • 82.55 (n)
  • 82.9 (a)
cow
(Bos Taurus)
Mammalia FARP2 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FARP2 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FARP2 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves FARP2 35
  • 73.18 (n)
  • 75.12 (a)
FARP2 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FARP2 36
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii farp2 35
  • 67.77 (n)
  • 68.71 (a)
wufc23d05 35
farp2 36
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001287 35
  • 52.61 (n)
  • 45.59 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cdep 35
  • 52.77 (n)
  • 45.76 (a)
Cdep 36
  • 36 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3850 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8849 36
  • 44 (a)
OneToMany
Species with no ortholog for FARP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FARP2 Gene

ENSEMBL:
Gene Tree for FARP2 (if available)
TreeFam:
Gene Tree for FARP2 (if available)

Paralogs for FARP2 Gene

genes like me logo Genes that share paralogs with FARP2: view

Variants for FARP2 Gene

Sequence variations from dbSNP and Humsavar for FARP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs16843643 - 241,413,353(+) CTCAA(A/C)GTGAA reference, missense
rs757978 - 241,431,686(-) TTTTG(A/G/T)TGGTG reference, missense
rs41342147 - 241,468,173(-) TAGGA(C/T)CTCGT reference, missense
rs372388 -- 241,433,604(+) ATTCA(A/G)AATGT intron-variant
rs373706 -- 241,471,068(-) CTTCA(A/G)AACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FARP2 Gene

Variant ID Type Subtype PubMed ID
nsv876225 CNV Gain 21882294
nsv3244 CNV Loss 18451855
esv25720 CNV Loss 19812545
esv269060 CNV Insertion 20981092
esv2721996 CNV Deletion 23290073
esv2721997 CNV Deletion 23290073
esv2721998 CNV Deletion 23290073
esv2662745 CNV Deletion 23128226
esv2721999 CNV Deletion 23290073
nsv876226 CNV Loss 21882294
esv2722000 CNV Deletion 23290073
esv2722001 CNV Deletion 23290073
dgv1296e1 CNV Complex 17122850
esv2722002 CNV Deletion 23290073
esv2722003 CNV Deletion 23290073
esv2722004 CNV Deletion 23290073

Variation tolerance for FARP2 Gene

Residual Variation Intolerance Score: 98.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.70; 86.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FARP2 Gene

HapMap Linkage Disequilibrium report
FARP2
Human Gene Mutation Database (HGMD)
FARP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FARP2 Gene

Disorders for FARP2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FARP2 Gene - From: OMIM and DISEASES

Disorder Aliases PubMed IDs
verheij syndrome
  • chromosome 8q24.3 deletion syndrome
aarskog-scott syndrome
  • aarskog syndrome
- elite association - COSMIC cancer census association via MalaCards
Search FARP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FARP2

Genetic Association Database (GAD)
FARP2
Human Genome Epidemiology (HuGE) Navigator
FARP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FARP2
genes like me logo Genes that share disorders with FARP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FARP2 Gene

Publications for FARP2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling. (PMID: 12351724) Kubo T. … Tohyama M. (J. Neurosci. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  5. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PMID: 23455922) Varjosalo M. … Superti-Furga G. (Nat. Methods 2013) 3

Products for FARP2 Gene

Sources for FARP2 Gene

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