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Aliases for FARP2 Gene

Aliases for FARP2 Gene

  • FERM, RhoGEF And Pleckstrin Domain Protein 2 2 3
  • Pleckstrin Homology Domain-Containing Family C Member 3 3 4
  • PH Domain-Containing Family C Member 3 3 4
  • FERM Domain Including RhoGEF 3 4
  • PLEKHC3 3 4
  • FIR 3 4
  • FERM, RhoGEF And Pleckstrin Domain-Containing Protein 2 3
  • FGD1-Related Cdc42-GEF 3
  • KIAA0793 4
  • FRG 3

External Ids for FARP2 Gene

Previous GeneCards Identifiers for FARP2 Gene

  • GC02M239859
  • GC02P242315
  • GC02P242616
  • GC02P242015
  • GC02P234051

Summaries for FARP2 Gene

GeneCards Summary for FARP2 Gene

FARP2 (FERM, RhoGEF And Pleckstrin Domain Protein 2) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and L1CAM interactions. GO annotations related to this gene include phospholipid binding and cytoskeletal protein binding. An important paralog of this gene is FRMD3.

UniProtKB/Swiss-Prot for FARP2 Gene

  • Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity).

Gene Wiki entry for FARP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FARP2 Gene

Genomics for FARP2 Gene

Regulatory Elements for FARP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FARP2 Gene

Start:
241,356,243 bp from pter
End:
241,495,074 bp from pter
Size:
138,832 bases
Orientation:
Plus strand

Genomic View for FARP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FARP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FARP2 Gene

Proteins for FARP2 Gene

  • Protein details for FARP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94887-FARP2_HUMAN
    Recommended name:
    FERM, RhoGEF and pleckstrin domain-containing protein 2
    Protein Accession:
    O94887
    Secondary Accessions:
    • B7Z6J8
    • F5GZ84
    • Q53QM5
    • Q8WU27
    • Q9UFE7

    Protein attributes for FARP2 Gene

    Size:
    1054 amino acids
    Molecular mass:
    119888 Da
    Quaternary structure:
    • Interacts with PLXNA1. Interaction with PLXNA1 or PIP5K1C lowers its guanine nucleotide exchange activity. Dissociates from PLXNA1 when SEMA3A binds to the receptor. Interacts with PIP5K1C via its FERM domain. The interaction with PIP5K1C is enhanced by SEMA3A binding. Interacts with RAC1 (By similarity).
    SequenceCaution:
    • Sequence=BAA34513.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FARP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FARP2 Gene

Proteomics data for FARP2 Gene at MOPED

Post-translational modifications for FARP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FARP2 Gene

No data available for DME Specific Peptides for FARP2 Gene

Domains for FARP2 Gene

Gene Families for FARP2 Gene

HGNC:
  • ARHGEF :Rho guanine nucleotide exchange factors
  • PLEKH :Pleckstrin homology (PH) domain containing

Suggested Antigen Peptide Sequences for FARP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94887

UniProtKB/Swiss-Prot:

FARP2_HUMAN :
  • O94887
Domain:
  • Intramolecular interaction between the DH domain and the PH domains can stabilize the protein in an autoinhibited conformation.
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 FERM domain.
  • Contains 2 PH domains.
genes like me logo Genes that share domains with FARP2: view

Function for FARP2 Gene

Molecular function for FARP2 Gene

UniProtKB/Swiss-Prot Function: Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity).

Gene Ontology (GO) - Molecular Function for FARP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IDA 12351724
GO:0008092 cytoskeletal protein binding IEA --
GO:0030676 Rac guanyl-nucleotide exchange factor activity ISS --
genes like me logo Genes that share ontologies with FARP2: view
genes like me logo Genes that share phenotypes with FARP2: view

Animal Models for FARP2 Gene

MGI Knock Outs for FARP2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FARP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for FARP2 Gene

Localization for FARP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FARP2 Gene COMPARTMENTS Subcellular localization image for FARP2 gene
Compartment Confidence
cytosol 4
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FARP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12351724
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0019898 extrinsic component of membrane IEA --
genes like me logo Genes that share ontologies with FARP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FARP2 Gene

Pathways for FARP2 Gene

genes like me logo Genes that share pathways with FARP2: view

Pathways by source for FARP2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for FARP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion ISS --
GO:0007411 axon guidance TAS --
GO:0016322 neuron remodeling IDA 12351724
GO:0016601 Rac protein signal transduction IDA 12351724
GO:0030316 osteoclast differentiation ISS --
genes like me logo Genes that share ontologies with FARP2: view

Compounds for FARP2 Gene

(3) HMDB Compounds for FARP2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with FARP2: view

Transcripts for FARP2 Gene

Unigene Clusters for FARP2 Gene

FERM, RhoGEF and pleckstrin domain protein 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FARP2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FARP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FARP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20a ·
SP1: - - - - - -
SP2: - - - -
SP3:
SP4:
SP5:
SP6: - -
SP7:
SP8:
SP9: - -

ExUns: 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29
SP1: - -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for FARP2 Gene

GeneLoc Exon Structure for
FARP2
ECgene alternative splicing isoforms for
FARP2

Expression for FARP2 Gene

mRNA expression in normal human tissues for FARP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FARP2 Gene

SOURCE GeneReport for Unigene cluster for FARP2 Gene Hs.726316

genes like me logo Genes that share expressions with FARP2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FARP2 Gene

Orthologs for FARP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FARP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FARP2 35
  • 96.71 (n)
  • 95.07 (a)
FARP2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FARP2 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FARP2 35
  • 82.83 (n)
  • 80.95 (a)
FARP2 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Farp2 35
  • 83.32 (n)
  • 83.73 (a)
Farp2 16
Farp2 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FARP2 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FARP2 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Farp2 35
  • 82.55 (n)
  • 82.9 (a)
chicken
(Gallus gallus)
Aves FARP2 35
  • 73.18 (n)
  • 75.12 (a)
FARP2 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FARP2 36
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii farp2 35
  • 67.77 (n)
  • 68.71 (a)
farp2 36
  • 67 (a)
OneToOne
wufc23d05 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001287 35
  • 52.61 (n)
  • 45.59 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cdep 35
  • 52.77 (n)
  • 45.76 (a)
Cdep 36
  • 36 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3850 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8849 36
  • 44 (a)
OneToMany
Species with no ortholog for FARP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FARP2 Gene

ENSEMBL:
Gene Tree for FARP2 (if available)
TreeFam:
Gene Tree for FARP2 (if available)

Paralogs for FARP2 Gene

genes like me logo Genes that share paralogs with FARP2: view

Variants for FARP2 Gene

Sequence variations from dbSNP and Humsavar for FARP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs372388 -- 241,433,604(+) ATTCA(A/G)AATGT intron-variant
rs373706 -- 241,471,068(-) CTTCA(A/G)AACAG intron-variant
rs374717 -- 241,472,093(-) AACAG(A/G)ACCCC intron-variant
rs375025 -- 241,472,018(-) CCAGA(A/T)AACAG intron-variant
rs390822 -- 241,472,002(-) CCACA(A/G/T)AACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FARP2 Gene

Variant ID Type Subtype PubMed ID
nsv876225 CNV Gain 21882294
nsv3244 CNV Loss 18451855
esv25720 CNV Loss 19812545
esv269060 CNV Insertion 20981092
esv2721996 CNV Deletion 23290073
esv2721997 CNV Deletion 23290073
esv2721998 CNV Deletion 23290073
esv2662745 CNV Deletion 23128226
esv2721999 CNV Deletion 23290073
nsv876226 CNV Loss 21882294
esv2722000 CNV Deletion 23290073
esv2722001 CNV Deletion 23290073
dgv1296e1 CNV Complex 17122850
esv2722002 CNV Deletion 23290073
esv2722003 CNV Deletion 23290073
esv2722004 CNV Deletion 23290073

Relevant External Links for FARP2 Gene

HapMap Linkage Disequilibrium report
FARP2
Human Gene Mutation Database (HGMD)
FARP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FARP2 Gene

Disorders for FARP2 Gene

(1) University of Copenhagen DISEASES for FARP2 Gene

Relevant External Links for FARP2

Genetic Association Database (GAD)
FARP2
Human Genome Epidemiology (HuGE) Navigator
FARP2
genes like me logo Genes that share disorders with FARP2: view

No data available for UniProtKB/Swiss-Prot for FARP2 Gene

Publications for FARP2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling. (PMID: 12351724) Kubo T. … Tohyama M. (J. Neurosci. 2002) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk. (PMID: 20062064) Crowther-Swanepoel D. … Houlston R.S. (Nat. Genet. 2010) 3 48

Products for FARP2 Gene

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