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Aliases for FARP1 Gene

Aliases for FARP1 Gene

  • FERM, RhoGEF (ARHGEF) And Pleckstrin Domain Protein 1 (Chondrocyte-Derived) 2 3
  • CDEP 3 4 6
  • Pleckstrin Homology Domain-Containing Family C Member 2 3 4
  • Chondrocyte-Derived Ezrin-Like Protein 3 4
  • PH Domain-Containing Family C Member 2 3 4
  • PLEKHC2 3 4
  • FERM, RhoGEF And Pleckstrin Domain-Containing Protein 1 3
  • Protein Phosphatase 1, Regulatory Subunit 75 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 75 2
  • FARP1-IT1 3
  • PPP1R75 3

External Ids for FARP1 Gene

Summaries for FARP1 Gene

Entrez Gene Summary for FARP1 Gene

  • This gene encodes a protein containing a FERM (4.2, exrin, radixin, moesin) domain, a Dbl homology domain, and two pleckstrin homology domains. These domains are found in guanine nucleotide exchange factors and proteins that link the cytoskeleton to the cell membrane. The encoded protein functions in neurons to promote dendritic growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

GeneCards Summary for FARP1 Gene

FARP1 (FERM, RhoGEF (ARHGEF) And Pleckstrin Domain Protein 1 (Chondrocyte-Derived)) is a Protein Coding gene. Among its related pathways are Regulation of RhoA activity. GO annotations related to this gene include phospholipid binding and cytoskeletal protein binding. An important paralog of this gene is FRMD3.

UniProtKB/Swiss-Prot for FARP1 Gene

  • Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity).

Gene Wiki entry for FARP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FARP1 Gene

Genomics for FARP1 Gene

Genomic Location for FARP1 Gene

Start:
98,142,562 bp from pter
End:
98,455,176 bp from pter
Size:
312,615 bases
Orientation:
Plus strand

Genomic View for FARP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FARP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FARP1 Gene

Regulatory Elements for FARP1 Gene

Proteins for FARP1 Gene

  • Protein details for FARP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4F1-FARP1_HUMAN
    Recommended name:
    FERM, RhoGEF and pleckstrin domain-containing protein 1
    Protein Accession:
    Q9Y4F1
    Secondary Accessions:
    • Q5JVI9
    • Q6IQ29

    Protein attributes for FARP1 Gene

    Size:
    1045 amino acids
    Molecular mass:
    118633 Da
    Quaternary structure:
    • Interacts with CADM1. Interacts with RAC1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for FARP1 Gene

    Alternative splice isoforms for FARP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FARP1 Gene

Proteomics data for FARP1 Gene at MOPED

Post-translational modifications for FARP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FARP1 Gene

Domains for FARP1 Gene

Gene Families for FARP1 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing
  • ARHGEF :Rho guanine nucleotide exchange factors
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

UniProtKB/Swiss-Prot:

FARP1_HUMAN
Domain:
  • Intramolecular interaction between the DH domain and the PH domains can stabilize the protein in an autoinhibited conformation.:
    • Q9Y4F1
  • Contains 1 DH (DBL-homology) domain.:
    • Q9Y4F1
  • Contains 1 FERM domain.:
    • Q9Y4F1
  • Contains 2 PH domains.:
    • Q9Y4F1
genes like me logo Genes that share domains with FARP1: view

Function for FARP1 Gene

Molecular function for FARP1 Gene

UniProtKB/Swiss-Prot Function: Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity).
UniProtKB/Swiss-Prot Induction: Up-regulated in response to cAMP in cultured embryonic chondrocytes.

Gene Ontology (GO) - Molecular Function for FARP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity TAS 9425278
GO:0008092 cytoskeletal protein binding IEA --
GO:0030676 Rac guanyl-nucleotide exchange factor activity ISS --
GO:0048365 Rac GTPase binding --
genes like me logo Genes that share ontologies with FARP1: view

Phenotypes for FARP1 Gene

GenomeRNAi human phenotypes for FARP1:
genes like me logo Genes that share phenotypes with FARP1: view

miRNA for FARP1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FARP1 Gene

Localization for FARP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FARP1 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell junction, synapse, synaptosome. Cytoplasm, cytosol. Cell projection, filopodium. Cell projection, dendrite. Cell projection, dendritic spine. Note=Recruited to the cell membrane via interaction with CADM1. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FARP1 Gene COMPARTMENTS Subcellular localization image for FARP1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 4
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for FARP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol ISS --
GO:0005856 cytoskeleton IEA --
GO:0030054 cell junction IEA --
GO:0030175 filopodium IEA --
genes like me logo Genes that share ontologies with FARP1: view

Pathways for FARP1 Gene

SuperPathways for FARP1 Gene

Superpath Contained pathways
1 Regulation of RhoA activity
genes like me logo Genes that share pathways with FARP1: view

Pathways by source for FARP1 Gene

1 BioSystems pathway for FARP1 Gene

Interacting Proteins for FARP1 Gene

Gene Ontology (GO) - Biological Process for FARP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007416 synapse assembly ISS --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0035023 regulation of Rho protein signal transduction --
GO:0043547 positive regulation of GTPase activity TAS 9425278
GO:0048813 dendrite morphogenesis ISS --
genes like me logo Genes that share ontologies with FARP1: view

Compounds for FARP1 Gene

(1) HMDB Compounds for FARP1 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4
genes like me logo Genes that share compounds with FARP1: view

Transcripts for FARP1 Gene

Unigene Clusters for FARP1 Gene

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FARP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a ·
SP1: - - - - - - -
SP2: - - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

ExUns: 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34
SP1: -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for FARP1 Gene

GeneLoc Exon Structure for
FARP1
ECgene alternative splicing isoforms for
FARP1

Expression for FARP1 Gene

mRNA expression in normal human tissues for FARP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FARP1 Gene

SOURCE GeneReport for Unigene cluster for FARP1 Gene Hs.403917

mRNA Expression by UniProt/SwissProt for FARP1 Gene

Q9Y4F1-FARP1_HUMAN
Tissue specificity: Detected in cAMP-treated chondrocytes, but not in untreated chondrocytes. Detected in fetal brain, heart and spleen, and in adult testis, kidney and lung.
genes like me logo Genes that share expressions with FARP1: view

Orthologs for FARP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FARP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FARP1 36
  • 99.49 (n)
  • 99.52 (a)
FARP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FARP1 36
  • 88.7 (n)
  • 91.57 (a)
FARP1 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FARP1 36
  • 90.4 (n)
  • 95.4 (a)
FARP1 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Farp1 36
  • 86.32 (n)
  • 91.96 (a)
Farp1 16
Farp1 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FARP1 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FARP1 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Farp1 36
  • 86.51 (n)
  • 92.54 (a)
chicken
(Gallus gallus)
Aves FARP1 36
  • 78.99 (n)
  • 84.67 (a)
FARP1 37
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FARP1 37
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia farp1 36
  • 72.76 (n)
  • 78.92 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10646 36
zebrafish
(Danio rerio)
Actinopterygii farp1 37
  • 71 (a)
OneToOne
LOC100329707 36
  • 69.86 (n)
  • 70.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cdep 37
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F52D10.6 38
  • 29 (a)
frm-3 38
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8849 37
  • 44 (a)
OneToMany
Species with no ortholog for FARP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FARP1 Gene

ENSEMBL:
Gene Tree for FARP1 (if available)
TreeFam:
Gene Tree for FARP1 (if available)

Paralogs for FARP1 Gene

genes like me logo Genes that share paralogs with FARP1: view

Variants for FARP1 Gene

Sequence variations from dbSNP and Humsavar for FARP1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs1792 -- 98,435,752(+) GAAAG(A/G)AGGCA intron-variant
rs4584 -- 98,449,615(+) GTGTA(C/G)CTGGA utr-variant-3-prime
rs9168 -- 98,449,329(+) CATTT(A/C)CCTTT utr-variant-3-prime
rs12261 -- 98,448,293(+) TTGAG(C/T)CACAA synonymous-codon, reference
rs185885 -- 98,172,786(+) TCCTT(A/G)AACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FARP1 Gene

Variant ID Type Subtype PubMed ID
nsv7246 OTHER Inversion 18451855
esv2751157 CNV Loss 17911159
esv27463 CNV Loss 19812545
esv269505 CNV Insertion 20981092
esv2642055 CNV Insertion 19546169
nsv456087 CNV Loss 19166990
nsv528803 CNV Loss 19592680
esv2657451 CNV Deletion 23128226
nsv818991 CNV Loss 17921354
esv34957 CNV Loss 17911159
dgv585e1 CNV Complex 17122850
nsv900942 CNV Loss 21882294
esv2568558 CNV Insertion 19546169
nsv471172 CNV Gain 18288195
nsv456088 CNV Gain 19166990
nsv510359 CNV Loss 20534489
nsv832695 CNV Loss 17160897
nsv509511 CNV Insertion 20534489
nsv900943 CNV Loss 21882294
dgv1782n71 CNV Loss 21882294
nsv517409 CNV Gain+Loss 19592680
esv988052 CNV Insertion 20482838
esv1283656 CNV Insertion 17803354

Relevant External Links for FARP1 Gene

HapMap Linkage Disequilibrium report
FARP1

Disorders for FARP1 Gene

Relevant External Links for FARP1

Genetic Association Database (GAD)
FARP1
Human Genome Epidemiology (HuGE) Navigator
FARP1
genes like me logo Genes that share disorders with FARP1: view

No data available for UniProtKB/Swiss-Prot for FARP1 Gene

Publications for FARP1 Gene

  1. Molecular cloning and characterization of CDEP, a novel human protein containing the ezrin-like domain of the band 4.1 superfamily and the Dbl homology domain of rho guanine nucleotide exchange factors. (PMID: 9425278) Koyano Y. … Kato Y. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 23
  2. Structural basis for autoinhibition of the guanine nucleotide exchange factor FARP2. (PMID: 23375260) He X. … Zhang X. (Structure 2013) 3 4
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Non-replication of association for six polymorphisms from meta-analysis of genome-wide association studies of Parkinson's disease: large-scale collaborative study. (PMID: 19475631) Evangelou E. … Ioannidis J.P. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 49

Products for FARP1 Gene

Sources for FARP1 Gene

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