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Aliases for FARP1 Gene

Aliases for FARP1 Gene

  • FERM, ARH/RhoGEF And Pleckstrin Domain Protein 1 2 3 5
  • FERM, RhoGEF (ARHGEF) And Pleckstrin Domain Protein 1 (Chondrocyte-Derived) 2 3
  • Pleckstrin Homology Domain-Containing Family C Member 2 3 4
  • Protein Phosphatase 1, Regulatory Subunit 75 2 3
  • Chondrocyte-Derived Ezrin-Like Protein 3 4
  • PH Domain-Containing Family C Member 2 3 4
  • PLEKHC2 3 4
  • CDEP 3 4
  • FERM, RhoGEF And Pleckstrin Domain-Containing Protein 1 3
  • FARP1-IT1 3
  • PPP1R75 3

External Ids for FARP1 Gene

Previous GeneCards Identifiers for FARP1 Gene

  • GC13P097155
  • GC13P093182
  • GC13P097632
  • GC13P096493
  • GC13P097593
  • GC13P098795
  • GC13P079393

Summaries for FARP1 Gene

Entrez Gene Summary for FARP1 Gene

  • This gene encodes a protein containing a FERM (4.2, exrin, radixin, moesin) domain, a Dbl homology domain, and two pleckstrin homology domains. These domains are found in guanine nucleotide exchange factors and proteins that link the cytoskeleton to the cell membrane. The encoded protein functions in neurons to promote dendritic growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

GeneCards Summary for FARP1 Gene

FARP1 (FERM, ARH/RhoGEF And Pleckstrin Domain Protein 1) is a Protein Coding gene. Among its related pathways are Regulation of RhoA activity. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity and Rac GTPase binding. An important paralog of this gene is FARP2.

UniProtKB/Swiss-Prot for FARP1 Gene

  • Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity).

Gene Wiki entry for FARP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FARP1 Gene

Genomics for FARP1 Gene

Regulatory Elements for FARP1 Gene

Enhancers for FARP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around FARP1 on UCSC Golden Path with GeneCards custom track

Promoters for FARP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FARP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FARP1 Gene

Chromosome:
13
Start:
98,142,562 bp from pter
End:
98,455,176 bp from pter
Size:
312,615 bases
Orientation:
Plus strand

Genomic View for FARP1 Gene

Genes around FARP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FARP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FARP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FARP1 Gene

Proteins for FARP1 Gene

  • Protein details for FARP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4F1-FARP1_HUMAN
    Recommended name:
    FERM, RhoGEF and pleckstrin domain-containing protein 1
    Protein Accession:
    Q9Y4F1
    Secondary Accessions:
    • Q5JVI9
    • Q6IQ29

    Protein attributes for FARP1 Gene

    Size:
    1045 amino acids
    Molecular mass:
    118633 Da
    Quaternary structure:
    • Interacts with CADM1. Interacts with RAC1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for FARP1 Gene

    Alternative splice isoforms for FARP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FARP1 Gene

Post-translational modifications for FARP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FARP1 Gene

Domains & Families for FARP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y4F1

UniProtKB/Swiss-Prot:

FARP1_HUMAN :
  • Intramolecular interaction between the DH domain and the PH domains can stabilize the protein in an autoinhibited conformation.
Domain:
  • Intramolecular interaction between the DH domain and the PH domains can stabilize the protein in an autoinhibited conformation.
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 FERM domain.
  • Contains 2 PH domains.
genes like me logo Genes that share domains with FARP1: view

Function for FARP1 Gene

Molecular function for FARP1 Gene

UniProtKB/Swiss-Prot Function:
Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to cAMP in cultured embryonic chondrocytes.

Gene Ontology (GO) - Molecular Function for FARP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity TAS 9425278
GO:0008092 cytoskeletal protein binding IEA --
GO:0030676 Rac guanyl-nucleotide exchange factor activity IEA,ISS --
GO:0048365 Rac GTPase binding IEA --
genes like me logo Genes that share ontologies with FARP1: view
genes like me logo Genes that share phenotypes with FARP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FARP1 Gene

Localization for FARP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FARP1 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell junction, synapse, synaptosome. Cytoplasm, cytosol. Cell projection, filopodium. Cell projection, dendrite. Cell projection, dendritic spine. Note=Recruited to the cell membrane via interaction with CADM1. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FARP1 Gene COMPARTMENTS Subcellular localization image for FARP1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
plasma membrane 4
nucleus 3

Gene Ontology (GO) - Cellular Components for FARP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IEA,ISS --
GO:0005856 cytoskeleton IEA --
GO:0030054 cell junction IEA --
GO:0030175 filopodium IEA --
genes like me logo Genes that share ontologies with FARP1: view

Pathways & Interactions for FARP1 Gene

SuperPathways for FARP1 Gene

Superpath Contained pathways
1 Regulation of RhoA activity
genes like me logo Genes that share pathways with FARP1: view

Pathways by source for FARP1 Gene

1 BioSystems pathway for FARP1 Gene

Gene Ontology (GO) - Biological Process for FARP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007416 synapse assembly IEA,ISS --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0048813 dendrite morphogenesis IEA,ISS --
genes like me logo Genes that share ontologies with FARP1: view

No data available for SIGNOR curated interactions for FARP1 Gene

Drugs & Compounds for FARP1 Gene

(1) Drugs for FARP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with FARP1: view

Transcripts for FARP1 Gene

Unigene Clusters for FARP1 Gene

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FARP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a ·
SP1: - - - - - - -
SP2: - - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

ExUns: 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34
SP1: -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for FARP1 Gene

GeneLoc Exon Structure for
FARP1
ECgene alternative splicing isoforms for
FARP1

Expression for FARP1 Gene

mRNA expression in normal human tissues for FARP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FARP1 Gene

This gene is overexpressed in Frontal cortex (8.6), Brain (8.6), and Fetal ovary (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FARP1 Gene



Protein tissue co-expression partners for FARP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FARP1 Gene:

FARP1

SOURCE GeneReport for Unigene cluster for FARP1 Gene:

Hs.403917

mRNA Expression by UniProt/SwissProt for FARP1 Gene:

Q9Y4F1-FARP1_HUMAN
Tissue specificity: Detected in cAMP-treated chondrocytes, but not in untreated chondrocytes. Detected in fetal brain, heart and spleen, and in adult testis, kidney and lung.
genes like me logo Genes that share expression patterns with FARP1: view

Primer Products

No data available for mRNA differential expression in normal tissues for FARP1 Gene

Orthologs for FARP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FARP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FARP1 34
  • 88.7 (n)
  • 91.57 (a)
FARP1 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FARP1 34
  • 90.4 (n)
  • 95.4 (a)
FARP1 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Farp1 34
  • 86.32 (n)
  • 91.96 (a)
Farp1 16
Farp1 35
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FARP1 34
  • 99.49 (n)
  • 99.52 (a)
FARP1 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Farp1 34
  • 86.51 (n)
  • 92.54 (a)
oppossum
(Monodelphis domestica)
Mammalia FARP1 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FARP1 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves FARP1 34
  • 78.99 (n)
  • 84.67 (a)
FARP1 35
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FARP1 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia farp1 34
  • 72.76 (n)
  • 78.92 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100329707 34
  • 69.86 (n)
  • 70.64 (a)
farp1 35
  • 71 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10646 34
fruit fly
(Drosophila melanogaster)
Insecta Cdep 35
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F52D10.6 36
  • 29 (a)
frm-3 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8849 35
  • 44 (a)
OneToMany
Species where no ortholog for FARP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FARP1 Gene

ENSEMBL:
Gene Tree for FARP1 (if available)
TreeFam:
Gene Tree for FARP1 (if available)

Paralogs for FARP1 Gene

genes like me logo Genes that share paralogs with FARP1: view

Variants for FARP1 Gene

Sequence variations from dbSNP and Humsavar for FARP1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
VAR_035851 A breast cancer sample
rs9300466 - 98,213,265(+) GAGGC(C/T)GACCC reference, missense
rs1792 -- 98,435,752(+) GAAAG(A/G)AGGCA intron-variant
rs4584 -- 98,449,615(+) GTGTA(C/G)CTGGA utr-variant-3-prime
rs9168 -- 98,449,329(+) CATTT(A/C)CCTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FARP1 Gene

Variant ID Type Subtype PubMed ID
dgv3340n54 CNV gain 21841781
dgv3341n54 CNV loss 21841781
dgv3342n54 CNV gain 21841781
dgv3343n54 CNV loss 21841781
dgv3344n54 CNV gain 21841781
dgv3345n54 CNV loss 21841781
esv1283656 CNV insertion 17803354
esv2568558 CNV insertion 19546169
esv2642055 CNV insertion 19546169
esv2657451 CNV deletion 23128226
esv27463 CNV loss 19812545
esv2751157 CNV loss 17911159
esv2759959 CNV loss 17122850
esv3305227 CNV mobile element insertion 20981092
esv3310565 CNV novel sequence insertion 20981092
esv3334889 CNV duplication 20981092
esv3366644 CNV insertion 20981092
esv3382243 CNV insertion 20981092
esv3414683 CNV insertion 20981092
esv34957 CNV loss 17911159
esv3580856 CNV loss 25503493
esv3633305 CNV loss 21293372
esv3633306 CNV loss 21293372
esv3633309 CNV loss 21293372
esv3633310 CNV loss 21293372
esv988052 CNV insertion 20482838
nsv1039403 CNV loss 25217958
nsv1045047 CNV gain 25217958
nsv1118269 CNV deletion 24896259
nsv1121865 CNV deletion 24896259
nsv1134344 CNV deletion 24896259
nsv1138254 CNV deletion 24896259
nsv1142837 CNV tandem duplication 24896259
nsv1144697 CNV deletion 24896259
nsv456087 CNV loss 19166990
nsv456088 CNV gain 19166990
nsv471172 CNV gain 18288195
nsv473246 CNV novel sequence insertion 20440878
nsv476994 CNV novel sequence insertion 20440878
nsv509511 CNV insertion 20534489
nsv510359 OTHER sequence alteration 20534489
nsv517409 CNV gain+loss 19592680
nsv528803 CNV loss 19592680
nsv562855 CNV gain 21841781
nsv562860 CNV gain 21841781
nsv562863 CNV loss 21841781
nsv562866 CNV loss 21841781
nsv562867 CNV loss 21841781
nsv562868 CNV gain 21841781
nsv562871 CNV loss 21841781
nsv562872 CNV loss 21841781
nsv7246 OTHER inversion 18451855
nsv818991 CNV loss 17921354
nsv832695 CNV loss 17160897

Variation tolerance for FARP1 Gene

Residual Variation Intolerance Score: 33.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.63; 72.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FARP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FARP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FARP1 Gene

Disorders for FARP1 Gene

Relevant External Links for FARP1

Genetic Association Database (GAD)
FARP1
Human Genome Epidemiology (HuGE) Navigator
FARP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FARP1

No disorders were found for FARP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FARP1 Gene

Publications for FARP1 Gene

  1. Molecular cloning and characterization of CDEP, a novel human protein containing the ezrin-like domain of the band 4.1 superfamily and the Dbl homology domain of rho guanine nucleotide exchange factors. (PMID: 9425278) Koyano Y. … Kato Y. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 22 65
  2. Structural basis for autoinhibition of the guanine nucleotide exchange factor FARP2. (PMID: 23375260) He X. … Zhang X. (Structure 2013) 3 4 65
  3. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney S.J. … . (Mol. Psychiatry 2011) 3 46 65
  4. Non-replication of association for six polymorphisms from meta-analysis of genome-wide association studies of Parkinson's disease: large-scale collaborative study. (PMID: 19475631) Evangelou E. … Ioannidis J.P. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 65
  5. Voxelwise genome-wide association study (vGWAS). (PMID: 20171287) Stein J.L. … Thompson P. (Neuroimage 2010) 3 46 65

Products for FARP1 Gene

Sources for FARP1 Gene

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