Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FARP1 Gene

protein-coding   GIFtS: 59
GCID: GC13P098795

FERM, RhoGEF (ARHGEF) And Pleckstrin Domain Protein 1 (Chondrocyte-Derived)

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
FERM, RhoGEF (ARHGEF) And Pleckstrin Domain Protein 1
(Chondrocyte-Derived)1 2
     Protein Phosphatase 11
Chondrocyte-Derived Ezrin-Like Protein2 3     Regulatory Subunit 751
Pleckstrin Homology Domain-Containing Family C Member 22 3     PPP1R752
CDEP2 3     FERM, RhoGEF And Pleckstrin Domain-Containing Protein 12
PLEKHC22 3     Protein Phosphatase 1, Regulatory Subunit 752
PH Domain-Containing Family C Member 22 3     

External Ids:    HGNC: 35911   Entrez Gene: 101602   Ensembl: ENSG000001527677   OMIM: 6026545   UniProtKB: Q9Y4F13   

Export aliases for FARP1 gene to outside databases

Previous GC identifers: GC13P097155 GC13P093182 GC13P097632 GC13P096493 GC13P097593 GC13P079393


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FARP1 Gene:
This gene was originally isolated through subtractive hybridization due to its increased expression in
differentiated chondrocytes versus dedifferentiated chondrocytes. The resulting protein contains a predicted
ezrin-like domain, a Dbl homology domain, and a pleckstrin homology domain. It is believed to be a member of the
band 4.1 superfamily whose members link the cytoskeleton to the cell membrane. Two alternatively spliced
transcript variants encoding distinct isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for FARP1 Gene: 
FARP1 (FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)) is a protein-coding gene. Diseases associated with FARP1 include fatty liver disease, and liver disease. GO annotations related to this gene include cytoskeletal protein binding and phospholipid binding. An important paralog of this gene is EPB41L5.

UniProtKB/Swiss-Prot: FARP1_HUMAN, Q9Y4F1
Function: Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays
a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of
dendrite length and ultimately the formation of synapses (By similarity)

Gene Wiki entry for FARP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_009952.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FARP1 gene promoter:
         c-Fos   Elk-1   AML1a   AP-1   CREB   NRF-2   deltaCREB   c-Jun   Msx-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFARP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FARP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FARP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32.2   Ensembl cytogenetic band:  13q32.2   HGNC cytogenetic band: 13q32.2

FARP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FARP1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P098795:  view genomic region     (about GC identifiers)

Start:
98,794,816 bp from pter      End:
99,102,027 bp from pter
Size:
307,212 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FARP1_HUMAN, Q9Y4F1 (See protein sequence)
Recommended Name: FERM, RhoGEF and pleckstrin domain-containing protein 1  
Size: 1045 amino acids; 118633 Da
Subunit: Interacts with CADM1. Interacts with RAC1 (By similarity)
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell
junction, synapse, synaptosome (By similarity). Cytoplasm, cytosol (By similarity). Cell projection, filopodium
(By similarity). Cell projection, dendrite (By similarity). Cell projection, dendritic spine (By similarity).
Note=Recruited to the cell membrane via interaction with CADM1 (By similarity)
1 PDB 3D structure from and Proteopedia for FARP1:
4H6Y (3D)    
Secondary accessions: Q5JVI9 Q6IQ29
Alternative splicing: 3 isoforms:  Q9Y4F1-1   Q9Y4F1-2   Q9Y4F1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FARP1: NX_Q9Y4F1

Explore proteomics data for FARP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y4F1

  • FARP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FARP1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001001715.2  NP_005757.1  

    ENSEMBL proteins: 
     ENSP00000471242   ENSP00000322926   ENSP00000365765   ENSP00000469712   ENSP00000469420  
     ENSP00000472346   ENSP00000410930   ENSP00000469365   ENSP00000365771  

    Human Recombinant Protein Products for FARP1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FARP1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for FARP1
    GenScript Custom Purified and Recombinant Proteins Services for FARP1
    Novus Biologicals FARP1 Proteins
    Novus Biologicals FARP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FARP1 

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm ----
    GO:0005829cytosol ISS--
    GO:0005856cytoskeleton IEA--
    GO:0019898extrinsic to membrane ----

    FARP1 for ontologies           About GeneDecksing



    FARP1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FARP1
    GenScript Custom Superior Antibodies Services for FARP1
    Novus Biologicals FARP1 Antibodies
    Abcam antibodies for FARP1
    Cloud-Clone Corp. Antibodies for FARP1 
    Search ThermoFisher Antibodies for FARP1
    LSBio Antibodies in human, mouse, rat for FARP1 

    Assay Products for FARP1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FARP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FARP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FARP1 
    Cloud-Clone Corp. CLIAs for FARP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits
    ARHGEF: Rho guanine nucleotide exchange factors

    5/13 InterPro protein domains (see all 13):
     IPR019748 FERM_central
     IPR019750 Band_41_fam
     IPR000219 DH-domain
     IPR000798 Ez/rad/moesin_like
     IPR001849 Pleckstrin_homology

    Graphical View of Domain Structure for InterPro Entry Q9Y4F1

    ProtoNet protein and cluster: Q9Y4F1

    3 Blocks protein domains:
    IPB000219 DH domain
    IPB000299 Band 4.1 domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: FARP1_HUMAN, Q9Y4F1
    Domain: Intramolecular interaction between the DH domain and the PH domains can stabilize the protein in an
    autoinhibited conformation
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 FERM domain
    Similarity: Contains 2 PH domains


    FARP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FARP1_HUMAN, Q9Y4F1
    Function: Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays
    a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of
    dendrite length and ultimately the formation of synapses (By similarity)
    Induction: Up-regulated in response to cAMP in cultured embryonic chondrocytes

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005089Rho guanyl-nucleotide exchange factor activity TAS9425278
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--
    GO:0008092cytoskeletal protein binding IEA--
    GO:0030676Rac guanyl-nucleotide exchange factor activity ISS--
         
    FARP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FARP1:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FARP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FARP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FARP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FARP1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target FARP1:
    hsa-mir-204 (MIRT005826), hsa-let-7b (MIRT005052)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FARP1
    8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate FARP1 (see all 54):
    hsa-miR-21* hsa-miR-579 hsa-miR-3938 hsa-miR-193a-3p hsa-miR-19b-2* hsa-let-7d hsa-miR-429 hsa-miR-25
    SwitchGear 3'UTR luciferase reporter plasmidFARP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FARP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FARP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FARP1
    Sirion Biotech Customized adenovirus for overexpression of FARP1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for FARP1 (see all 13)
    OriGene ORF clones in mouse, rat for FARP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FARP1 (NM_001001715)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FARP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FARP1
    Sirion Biotech Customized lentivirus for stable overexpression of FARP1 
                         Customized lentivirus expression plasmids for stable overexpression of FARP1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FARP1
    Search LifeMap BioReagents cell lines for FARP1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FARP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FARP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of RhoA activity
    Regulation of RhoA activity


    1 BioSystems Pathway for FARP1
        Regulation of RhoA activity


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FARP1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for FARP1 (ENSP000003229264) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1CAENSP000003260314STRING: ENSP00000326031
    UBCENSP000003448184STRING: ENSP00000344818
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007416synapse assembly ISS--
    GO:0010923negative regulation of phosphatase activity IDA19389623
    GO:0035023regulation of Rho protein signal transduction IEA--
    GO:0048813dendrite morphogenesis ISS--

    FARP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FARP1

    1 HMDB Compound for FARP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    Search CenterWatch for drugs/clinical trials and news about FARP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FARP1 gene (2 alternative transcripts): 
    NM_001001715.2  NM_005766.2  

    Unigene Cluster for FARP1:

    FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
    Hs.403917  [show with all ESTs]
    Unigene Representative Sequence: BX537667
    18/42 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 42):
    ENST00000595437 ENST00000600648 ENST00000319562 ENST00000376581(uc001vni.3)
    ENST00000598389 ENST00000601361 ENST00000595817 ENST00000427404 ENST00000601656
    ENST00000602015 ENST00000598698 ENST00000599151 ENST00000601762 ENST00000595366
    ENST00000596545 ENST00000602272 ENST00000598346 ENST00000602171

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FARP1
    8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate FARP1 (see all 54):
    hsa-miR-21* hsa-miR-579 hsa-miR-3938 hsa-miR-193a-3p hsa-miR-19b-2* hsa-let-7d hsa-miR-429 hsa-miR-25
    SwitchGear 3'UTR luciferase reporter plasmidFARP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FARP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FARP1
    Clone
    Products:
         
    OriGene clones in human, mouse for FARP1 (see all 13)
    OriGene ORF clones in mouse, rat for FARP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FARP1 (NM_001001715)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FARP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FARP1
    Sirion Biotech Customized lentivirus for stable overexpression of FARP1 
                         Customized lentivirus expression plasmids for stable overexpression of FARP1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FARP1
    OriGene qSTAR qPCR primer pairs in human, mouse for FARP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FARP1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FARP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FARP1

    Additional mRNA sequence: 

    AB008430.1 BC041595.1 BC053593.1 BC065020.1 BC071592.1 BX537667.1 

    18 DOTS entries:

    DT.442782  DT.99934570  DT.95287263  DT.120786825  DT.40121143  DT.40121142  DT.100802250  DT.100802254 
    DT.100774272  DT.120786828  DT.120786853  DT.86837272  DT.101971052  DT.120786672  DT.120786812  DT.75116275 
    DT.75196487  DT.91916713 

    24/468 AceView cDNA sequences (see all 468):

    BX647479 AI869413 AI890282 BE271866 BQ007730 CB850636 AA443095 AA169740 
    AA404224 CA414321 AA069699 CK820466 AA084245 AI478646 BC041595 BU622088 
    BQ646351 BQ881649 AA330321 CA389987 BU931960 AA490465 AI767281 N46458 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for FARP1 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a ·
    SP1:        -     -           -     -     -                                                     -                             -                                 
    SP2:                          -     -     -                                                     -                             -                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34
    SP1:              -                                                                           
    SP2:              -     -                                                                     
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for FARP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FARP1 expression in normal human tissues (normalized intensities)      FARP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTCCCAGC
    FARP1 Expression
    About this image


    FARP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Neural Tube (Nervous System)
             Primitive Spinal Cord

    See FARP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FARP1

    SOURCE GeneReport for Unigene cluster: Hs.403917

    UniProtKB/Swiss-Prot: FARP1_HUMAN, Q9Y4F1
    Tissue specificity: Detected in cAMP-treated chondrocytes, but not in untreated chondrocytes. Detected in fetal
    brain, heart and spleen, and in adult testis, kidney and lung

        SABiosciences Custom PCR Arrays for FARP1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FARP1
    OriGene qSTAR qPCR primer pairs in human, mouse for FARP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FARP1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FARP1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FARP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FARP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FARP1 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Farp11 , 5 FERM, RhoGEF (Arhgef) and pleckstrin domain protein more1, 5 86.41(n)1
    91.96(a)1
      14 (64.86 cM)5
    2232541  NM_134082.31  NP_598843.31 
     1210352005 
    chicken
    (Gallus gallus)
    Aves FARP11 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein more 78.99(n)
    84.67(a)
      418781  NM_001252064.1  NP_001238993.1 
    lizard
    (Anolis carolinensis)
    Reptilia FARP16
    FERM, RhoGEF (ARHGEF) and pleckstrin domain protei...
    85(a)
    1 ↔ 1
    3(98214686-98446878)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX845339.12   -- 79.69(n)    BX845339.1 
    zebrafish
    (Danio rerio)
    Actinopterygii farp16
    FARP1 (2 of 2)6
    FERM, RhoGEF (ARHGEF) and pleckstrin domain protei...
    FERM, RhoGEF (ARHGEF) and pleckstrin domain protei...
    70(a)
    69(a)
    1 ↔ many
    1 ↔ many
    1(2058744-2200996)
    9(1177718-1186337)
    fruit fly
    (Drosophila melanogaster)
    Insecta Cdep6
    Cdep
    34(a)
    1 → many
    3R(736278-771298)


    ENSEMBL Gene Tree for FARP1 (if available)
    TreeFam Gene Tree for FARP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FARP1 gene
    EPB41L52  EPB412  FRMD32  EPB41L12  PTPN32  EPB41L4B2  PTPN42  FRMD52  
    EPB41L32  FRMD72  EPB41L4A2  FARP22  EPB41L22  
    18 SIMAP similar genes for FARP1 using alignment to 6 protein entries:     FARP1_HUMAN (see all proteins):
    FARP2    EPB41L3    PTPN4    PTPN3    EPB41L2    FRMD5
    FRMD7    PTPN14    EPB41L4A    EPB41L1    EPB41L5    PTPN21
    EPB41    EPB41L4B    EZR-ROS1    RDX    FRMD4B    MSN

    FARP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7674 SNPs in FARP1 are shown (see all 7674)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358514
    A breast cancer sample4--see VAR_0358512 R L mis40--------
    rs106059681,2
    C--79884384(+) CTAAC-/T/T   
       TTTTT
    TTTTA
    1 -- int1 trp30--------
    rs676833581,2
    C--79896662(+) CTTGT-/TTTTTT 1 -- int10--------
    rs346629911,2
    C--80009158(+) TTGAT-/T/TT  
            
    TTTTT
    1 -- int11NA 2
    rs1912621451,2
    C--98793484(+) CCCGGA/CCTAAT 2 -- us2k10--------
    rs1447941611,2
    --98793502(+) TTTTAG/TTTGGG 2 -- us2k10--------
    rs1831248101,2
    --98793629(+) TCCCTC/GGTGAT 2 -- us2k10--------
    rs1387340571,2
    --98793646(+) ATACAA/CTAGAG 2 -- us2k10--------
    rs726533701,2
    C,F--98793751(+) TATTTG/AGCTGG 2 -- us2k11Minor allele frequency- A:0.50NA 2
    rs741086731,2
    C,F--98793830(+) TGTGAT/ACCTCC 2 -- us2k11Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for FARP1 (98794816 - 99044816 bp, first 250kb of FARP1)

    Structural Variations
         Database of Genomic Variants (DGV) 10/23 variations for FARP1 (see all 23):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2657451CNV Deletion23128226
    esv988052CNV Insertion20482838
    esv1283656CNV Insertion17803354
    esv2642055CNV Insertion19546169
    nsv509511CNV Insertion20534489
    esv2568558CNV Insertion19546169
    esv269505CNV Insertion20981092
    esv2751157CNV Loss17911159
    nsv832695CNV Loss17160897
    nsv456087CNV Loss19166990

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FARP1
    DNA2.0 Custom Variant and Variant Library Synthesis for FARP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602654    OMIM disorders: --

    4 diseases for FARP1:    About MalaCards
    fatty liver disease    liver disease    parkinson's disease    alzheimer's disease


    FARP1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): FARP1
    Human Genome Epidemiology (HuGE) Navigator: FARP1 (2 documents)

    Export disorders for FARP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FARP1 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with FARP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of CDEP, a novel human protein containing the ezrin-liks domain of the band 4.1 superfamily and the Dbl homology domain of rho guanine nucleotide exchange factors. (PubMed id 9425278)1, 2, 3, 9 Koyano Y....Kato Y. (1997)
    2. Voxelwise genome-wide association study (vGWAS). (PubMed id 20171287)1, 4 Stein J.L....Thompson P. (2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Non-replication of association for six polymorphisms from meta-analysis of genome-wide association studies of Parkinson's disease: l arge-scale collaborative study. (PubMed id 19475631)1, 4 Evangelou E....Ioannidis J.P. (2010)
    5. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PubMed id 21116278)1, 4 Furney S.J....Lovestone S. (2010)
    6. Genome-wide association study identifies variants ass ociated with histologic features of nonalcoholic Fatty liver disease. (PubMed id 20708005)1, 4 Chalasani N....Rotter J.I. (2010)
    7. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Structural basis for autoinhibition of the guanine nucleotide exchange factor FARP2. (PubMed id 23375260)2 He X.... Zhang X. (2013)
    10. Genome-wide association study of d-amphetamine respons e in healthy volunteers identifies putative associations, including cadherin 13 (CDH13). (PubMed id 22952603)1 Hart A.B....Palmer A.A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10160 HGNC: 3591 AceView: FARP1 Ensembl:ENSG00000152767 euGenes: HUgn10160
    ECgene: FARP1 H-InvDB: FARP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FARP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FARP1 gene:
    Search GeneIP for patents involving FARP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FARP1  
     OriGene qPCR primer pairs and template standards for FARP1   OriGene Protein Over-expression Lysate for FARP1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FARP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for FARP1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FARP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FARP1   OriGene Custom Protein Services for FARP1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FARP1
     QIAGEN SeqTarget long-range PCR primers for resequencing FARP1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FARP1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FARP1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FARP1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FARP1
     GenScript Custom Purified and Recombinant Proteins Services for FARP1 GenScript cDNA clones with any tag delivered in your preferred vector for FARP1
     GenScript Custom Assay Services for FARP1 GenScript Custom Superior Antibodies Services for FARP1
     GenScript Custom overexpressing Cell Line Services for FARP1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FARP1 promoter
     Search Chromatin IP Primers for FARP1
     RT2 qPCR Primer Assay in human, mouse / rat FARP1
     Search GNC Networks for FARP1
     SABiosciences Custom PCR Arrays for FARP1
     Search Tocris compounds for FARP1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FARP1 antibodies
     FARP1 proteins
     FARP1 lysates
     Antibodies for FARP1
     See all of Abcam's Antibodies, Kits and Proteins for FARP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for FARP1
     Antibodies for FARP1
     ELISAs for FARP1
     CLIAs for FARP1
     Search LifeMap BioReagents cell lines for FARP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FARP1
     SwitchGear 3'UTR luciferase reporter plasmids for FARP1
     SwitchGear Promoter luciferase reporter plasmids for FARP1
     Search ThermoFisher Antibodies for FARP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FARP1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for FARP1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FARP1
    Customized:
     lentivirus for stable overexpression of FARP1
     lentivirus expression plasmids for stable overexpression of FARP1
     adenovirus for overexpression of FARP1
     LSBio Antibodies in human, mouse, rat for FARP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FARP1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4