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FARP1 Gene

protein-coding   GIFtS: 58
GCID: GC13P098795

FERM, RhoGEF (ARHGEF) And Pleckstrin Domain Protein 1 (Chondrocyte-Derived)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FERM, RhoGEF (ARHGEF) And Pleckstrin Domain Protein 1
(Chondrocyte-Derived)1 2
     Protein Phosphatase 11
CDEP2 3 5     Regulatory Subunit 751
Chondrocyte-Derived Ezrin-Like Protein2 3     FARP1-IT12
Pleckstrin Homology Domain-Containing Family C Member 22 3     PPP1R752
PLEKHC22 3     FERM, RhoGEF And Pleckstrin Domain-Containing Protein 12
PH Domain-Containing Family C Member 22 3     Protein Phosphatase 1, Regulatory Subunit 752

External Ids:    HGNC: 35911   Entrez Gene: 101602   Ensembl: ENSG000001527677   OMIM: 6026545   UniProtKB: Q9Y4F13   

Export aliases for FARP1 gene to outside databases

Previous GC identifers: GC13P097155 GC13P093182 GC13P097632 GC13P096493 GC13P097593 GC13P079393


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FARP1 Gene:
This gene encodes a protein containing a FERM (4.2, exrin, radixin, moesin) domain, a Dbl homology domain, and two
pleckstrin homology domains. These domains are found in guanine nucleotide exchange factors and proteins that
link the cytoskeleton to the cell membrane. The encoded protein functions in neurons to promote dendritic growth.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Nov 2013)

GeneCards Summary for FARP1 Gene:
FARP1 (FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)) is a protein-coding gene. Diseases associated with FARP1 include fatty liver disease, and liver disease. GO annotations related to this gene include cytoskeletal protein binding and phospholipid binding. An important paralog of this gene is EPB41L5.

UniProtKB/Swiss-Prot: FARP1_HUMAN, Q9Y4F1
Function: Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays
a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of
dendrite length and ultimately the formation of synapses (By similarity)

Gene Wiki entry for FARP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NT_009952.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FARP1 gene promoter:
         c-Fos   Elk-1   AML1a   AP-1   CREB   NRF-2   deltaCREB   c-Jun   Msx-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFARP1 promoter sequence
   Search Chromatin IP Primers for FARP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FARP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32.2   Ensembl cytogenetic band:  13q32.2   HGNC cytogenetic band: 13q32.2

FARP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FARP1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P098795:  view genomic region     (about GC identifiers)

Start:
98,794,816 bp from pter      End:
99,102,027 bp from pter
Size:
307,212 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FARP1_HUMAN, Q9Y4F1 (See protein sequence)
Recommended Name: FERM, RhoGEF and pleckstrin domain-containing protein 1  
Size: 1045 amino acids; 118633 Da
Subunit: Interacts with CADM1. Interacts with RAC1 (By similarity)
1 PDB 3D structure from and Proteopedia for FARP1:
4H6Y (3D)    
Secondary accessions: Q5JVI9 Q6IQ29
Alternative splicing: 3 isoforms:  Q9Y4F1-1   Q9Y4F1-2   Q9Y4F1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FARP1: NX_Q9Y4F1

Explore proteomics data for FARP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FARP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001001715.2  NP_001273768.1  NP_005757.1  

    ENSEMBL proteins: 
     ENSP00000471242   ENSP00000322926   ENSP00000365765   ENSP00000469712   ENSP00000469420  
     ENSP00000472346   ENSP00000410930   ENSP00000469365   ENSP00000365771  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits
    ARHGEF: Rho guanine nucleotide exchange factors

    Selected InterPro protein domains (see all 13):
     IPR019748 FERM_central
     IPR019750 Band_41_fam
     IPR000219 DH-domain
     IPR000798 Ez/rad/moesin_like
     IPR001849 Pleckstrin_homology

    Graphical View of Domain Structure for InterPro Entry Q9Y4F1

    ProtoNet protein and cluster: Q9Y4F1

    3 Blocks protein domains:
    IPB000219 DH domain
    IPB000299 Band 4.1 domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: FARP1_HUMAN, Q9Y4F1
    Domain: Intramolecular interaction between the DH domain and the PH domains can stabilize the protein in an
    autoinhibited conformation
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 FERM domain
    Similarity: Contains 2 PH domains


    FARP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FARP1_HUMAN, Q9Y4F1
    Function: Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays
    a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of
    dendrite length and ultimately the formation of synapses (By similarity)
    Induction: Up-regulated in response to cAMP in cultured embryonic chondrocytes

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005089Rho guanyl-nucleotide exchange factor activity TAS9425278
    GO:0008092cytoskeletal protein binding IEA--
    GO:0030676Rac guanyl-nucleotide exchange factor activity ISS--
    GO:0048365Rac GTPase binding IEA--
         
    FARP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FARP1:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target FARP1:
    hsa-mir-124-3p (MIRT023200), hsa-mir-26b-5p (MIRT030304), hsa-mir-204-5p (MIRT005826), hsa-let-7b-5p (MIRT005052)

    Block miRNA regulation of human, mouse, rat FARP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FARP1 (see all 54):
    hsa-miR-21* hsa-miR-579 hsa-miR-3938 hsa-miR-193a-3p hsa-miR-19b-2* hsa-let-7d hsa-miR-429 hsa-miR-25
    SwitchGear 3'UTR luciferase reporter plasmidFARP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FARP1

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    GenScript: all cDNA clones in your preferred vector (see all 2): FARP1 (NM_001001715)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FARP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FARP1_HUMAN, Q9Y4F1: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell
    junction, synapse, synaptosome (By similarity). Cytoplasm, cytosol (By similarity). Cell projection, filopodium
    (By similarity). Cell projection, dendrite (By similarity). Cell projection, dendritic spine (By similarity).
    Note=Recruited to the cell membrane via interaction with CADM1 (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton4
    cytosol4
    nucleus3

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol ISS--
    GO:0005856cytoskeleton IEA--
    GO:0019898extrinsic component of membrane ----
    GO:0030054cell junction IEA--

    FARP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FARP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of RhoA activity
    Regulation of RhoA activity


    1 BioSystems Pathway for FARP1
        Regulation of RhoA activity


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FARP1
    Interactions:

        Search GeneGlobe Interaction Network for FARP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for FARP1 (ENSP000003229264) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1CAENSP000003260314STRING: ENSP00000326031
    INSM1ENSP000003126314STRING: ENSP00000312631
    INSM2ENSP000003065234STRING: ENSP00000306523
    PIK3AP1ENSP000003398264STRING: ENSP00000339826
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007416synapse assembly ISS--
    GO:0010923negative regulation of phosphatase activity IDA19389623
    GO:0032314regulation of Rac GTPase activity ISS--
    GO:0032319regulation of Rho GTPase activity TAS9425278
    GO:0035023regulation of Rho protein signal transduction ----

    FARP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FARP1

    1 HMDB Compound for FARP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FARP1 gene (3 alternative transcripts): 
    NM_001001715.3  NM_001286839.1  NM_005766.3  

    Unigene Cluster for FARP1:

    FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
    Hs.403917  [show with all ESTs]
    Unigene Representative Sequence: BX537667
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 42):
    ENST00000595437 ENST00000600648 ENST00000319562 ENST00000376581(uc001vni.3)
    ENST00000598389 ENST00000601361 ENST00000595817 ENST00000427404 ENST00000601656
    ENST00000602015 ENST00000598698 ENST00000599151 ENST00000601762 ENST00000595366
    ENST00000596545 ENST00000602272 ENST00000598346 ENST00000602171
    miRNA
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    Block miRNA regulation of human, mouse, rat FARP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FARP1 (see all 54):
    hsa-miR-21* hsa-miR-579 hsa-miR-3938 hsa-miR-193a-3p hsa-miR-19b-2* hsa-let-7d hsa-miR-429 hsa-miR-25
    SwitchGear 3'UTR luciferase reporter plasmidFARP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FARP1
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): FARP1 (NM_001001715)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FARP1
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FARP1
      QuantiTect SYBR Green Assays in human, mouse, rat FARP1
      QuantiFast Probe-based Assays in human, mouse, rat FARP1

    Additional mRNA sequence: 

    AB008430.1 BC041595.1 BC053593.1 BC065020.1 BC071592.1 BX537667.1 

    18 DOTS entries:

    DT.442782  DT.99934570  DT.95287263  DT.120786825  DT.40121143  DT.40121142  DT.100802250  DT.100802254 
    DT.100774272  DT.120786828  DT.120786853  DT.86837272  DT.101971052  DT.120786672  DT.120786812  DT.75116275 
    DT.75196487  DT.91916713 

    Selected AceView cDNA sequences (see all 468):

    BU179876 BQ014327 BQ015258 NM_005766 CB851126 BM927159 AI365489 BM662940 
    AA535701 BI064005 BM977575 CK820466 AA084245 AI478646 BC041595 BU622088 
    BQ646351 BQ881649 AA330321 CA389987 BU931960 AA490465 AI767281 N46458 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FARP1 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a ·
    SP1:        -     -           -     -     -                                                     -                             -                                 
    SP2:                          -     -     -                                                     -                             -                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34
    SP1:              -                                                                           
    SP2:              -     -                                                                     
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for FARP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FARP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTCCCAGC
    FARP1 Expression
    About this image


    FARP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Neural Tube (Nervous System)
             Primitive Spinal Cord
     
     Lung (Respiratory System)
     
     Thyroid (Endocrine System)
     
     Kidney (Urinary System)
    FARP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FARP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.403917

    UniProtKB/Swiss-Prot: FARP1_HUMAN, Q9Y4F1
    Tissue specificity: Detected in cAMP-treated chondrocytes, but not in untreated chondrocytes. Detected in fetal
    brain, heart and spleen, and in adult testis, kidney and lung

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FARP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FARP1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Farp11 , 5 FERM, RhoGEF (Arhgef) and pleckstrin domain protein more1, 5 86.32(n)1
    91.96(a)1
      14 (64.86 cM)5
    2232541  NM_134082.31  NP_598843.31 
     1210352005 
    chicken
    (Gallus gallus)
    Aves FARP11 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein more 78.99(n)
    84.67(a)
      418781  NM_001252064.1  NP_001238993.1 
    lizard
    (Anolis carolinensis)
    Reptilia FARP16
    FERM, RhoGEF (ARHGEF) and pleckstrin domain protei...
    85(a)
    1 ↔ 1
    3(98214686-98446878)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX845339.12   -- 79.69(n)    BX845339.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003297071 FERM, RhoGEF, and pleckstrin domain protein 1-like 69.86(n)
    70.64(a)
      100329707  XM_002660330.3  XP_002660376.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cdep6
    Cdep
    35(a)
    1 → many
    3R(736278-771298)


    ENSEMBL Gene Tree for FARP1 (if available)
    TreeFam Gene Tree for FARP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FARP1 gene
    EPB41L52  EPB412  FRMD32  EPB41L12  PTPN32  EPB41L4B2  PTPN42  FRMD52  
    FRMD72  EPB41L32  EPB41L4A2  FARP22  EPB41L22  
    18 SIMAP similar genes for FARP1 using alignment to 6 protein entries:     FARP1_HUMAN (see all proteins):
    FARP2    EPB41L3    PTPN4    PTPN3    EPB41L2    FRMD5
    FRMD7    PTPN14    EPB41L4A    EPB41L1    EPB41L5    PTPN21
    EPB41    EPB41L4B    EZR-ROS1    RDX    FRMD4B    MSN

    FARP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FARP1 (see all 7674)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358514
    A breast cancer sample4--see VAR_0358512 R L mis40--------
    rs106059681,2
    C--79884384(+) CTAAC-/T/T   
       TTTTT
    TTTTA
    1 -- int1 trp30--------
    rs676833581,2
    C--79896662(+) CTTGT-/TTTTTT 1 -- int10--------
    rs346629911,2
    C--80009158(+) TTGAT-/T/TT  
            
    TTTTT
    1 -- int11NA 2
    rs1912621451,2
    C--98793484(+) CCCGGA/CCTAAT 2 -- us2k10--------
    rs1447941611,2
    --98793502(+) TTTTAG/TTTGGG 2 -- us2k10--------
    rs1831248101,2
    --98793629(+) TCCCTC/GGTGAT 2 -- us2k10--------
    rs1387340571,2
    --98793646(+) ATACAA/CTAGAG 2 -- us2k10--------
    rs726533701,2
    C,F--98793751(+) TATTTG/AGCTGG 2 -- us2k11Minor allele frequency- A:0.50NA 2
    rs741086731,2
    C,F--98793830(+) TGTGAT/ACCTCC 2 -- us2k11Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for FARP1 (98794816 - 99044816 bp, first 250kb of FARP1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FARP1 (see all 23):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2657451CNV Deletion23128226
    esv988052CNV Insertion20482838
    esv1283656CNV Insertion17803354
    esv2642055CNV Insertion19546169
    nsv509511CNV Insertion20534489
    esv2568558CNV Insertion19546169
    esv269505CNV Insertion20981092
    esv2751157CNV Loss17911159
    nsv832695CNV Loss17160897
    nsv456087CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for FARP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602654    OMIM disorders: --

    7 diseases for FARP1:    
    About MalaCards
    fatty liver disease    liver disease    breast and colorectal cancer    parkinson's disease
    obesity    alzheimer's disease    colorectal cancer


    FARP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FARP1
    Human Genome Epidemiology (HuGE) Navigator: FARP1 (2 documents)

    Export disorders for FARP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FARP1 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with FARP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of CDEP, a novel human protein containing the ezrin-like domain of the band 4.1 superfamily and the Dbl homology domain of rho guanine nucleotide exchange factors. (PubMed id 9425278)1, 2, 3, 9 Koyano Y....Kato Y. (Biochem. Biophys. Res. Commun. 1997)
    2. Structural basis for autoinhibition of the guanine nucleotide exchange factor FARP2. (PubMed id 23375260)1, 2 He X.... Zhang X. (Structure 2013)
    3. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PubMed id 21116278)1, 4 Furney S.J.... . (Mol. Psychiatry 2011)
    4. Voxelwise genome-wide association study (vGWAS). (PubMed id 20171287)1, 4 Stein J.L....Thompson P. (Neuroimage 2010)
    5. Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease. (PubMed id 20708005)1, 4 Chalasani N....Rotter J.I. (Gastroenterology 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Non-replication of association for six polymorphisms from meta-analysis of genome-wide association studies of Parkinson's disease: large-scale collaborative study. (PubMed id 19475631)1, 4 Evangelou E....Ioannidis J.P. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    8. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Genome-wide meta-analysis identifies new susceptibility loci for migraine. (PubMed id 23793025)1 Anttila V.... . (Nat. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10160 HGNC: 3591 AceView: FARP1 Ensembl:ENSG00000152767 euGenes: HUgn10160
    ECgene: FARP1 H-InvDB: FARP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FARP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FARP1 gene:
    Search GeneIP for patents involving FARP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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