Aliases for FARP1 Gene
Aliases for FARP1 Gene
- FERM, ARH/RhoGEF And Pleckstrin Domain Protein 1 2 3 5
- FERM, RhoGEF (ARHGEF) And Pleckstrin Domain Protein 1 (Chondrocyte-Derived) 2 3
- Pleckstrin Homology Domain-Containing Family C Member 2 3 4
- Protein Phosphatase 1, Regulatory Subunit 75 2 3
- Chondrocyte-Derived Ezrin-Like Protein 3 4
- PH Domain-Containing Family C Member 2 3 4
External Ids for FARP1 Gene
- HGNC: 3591
- Entrez Gene: 10160
- Ensembl: ENSG00000152767
- OMIM: 602654
- UniProtKB: Q9Y4F1
Previous GeneCards Identifiers for FARP1 Gene
- GC13P097155
- GC13P093182
- GC13P097632
- GC13P096493
- GC13P097593
- GC13P098795
- GC13P079393
Summaries for FARP1 Gene
-
This gene encodes a protein containing a FERM (4.2, exrin, radixin, moesin) domain, a Dbl homology domain, and two pleckstrin homology domains. These domains are found in guanine nucleotide exchange factors and proteins that link the cytoskeleton to the cell membrane. The encoded protein functions in neurons to promote dendritic growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
GeneCards Summary for FARP1 Gene
FARP1 (FERM, ARH/RhoGEF And Pleckstrin Domain Protein 1) is a Protein Coding gene. Among its related pathways are Regulation of RhoA activity. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity and Rac GTPase binding. An important paralog of this gene is FARP2.
UniProtKB/Swiss-Prot for FARP1 Gene
-
Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FARP1 Gene
Genomics for FARP1 Gene
Regulatory Elements for FARP1 Gene
Enhancers for FARP1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH13G098205 | 1 | Ensembl ENCODE dbSUPER | 19 | +65.0 | 65033 | 3.8 | JUND ZNF585B FOS YY1 | FARP1 RN7SKP8 MIR3170 |
| GH13G098213 | 1.4 | Ensembl ENCODE dbSUPER | 10.9 | +73.2 | 73214 | 5.4 | CBX3 ARNT RAD21 ZSCAN5C FOS RELB ZNF263 SMARCA5 REST ZEB2 | FARP1 MIR3170 ENSG00000269189 |
| GH13G098219 | 1 | ENCODE dbSUPER | 11.5 | +79.2 | 79153 | 4.5 | PKNOX1 CBX3 TAL1 FEZF1 EBF1 HIC1 TCF12 ZNF121 ZNF366 NCOR1 | FARP1 ENSG00000269189 MIR3170 |
| GH13G098326 | 1.2 | Ensembl ENCODE dbSUPER | 8.5 | +185.4 | 185389 | 2.5 | SOX5 SOX13 GATAD2A MAZ SAP130 TEAD1 GFI1B TEAD4 RBBP5 TEAD3 | FARP1 LOC105370327 GC13M098277 |
| GH13G098334 | 1 | ENCODE dbSUPER | 6.6 | +190.9 | 190943 | 1.1 | ELF3 SOX13 ZSCAN4 ZNF766 HNF4G NFE2 MAFK HOMEZ NFE2L2 GATAD2A | FARP1 ENSG00000269599 PIR47409 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FARP1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for FARP1 Gene
- Chromosome:
- 13
- Start:
- 98,142,562 bp from pter
- End:
- 98,455,176 bp from pter
- Size:
- 312,615 bases
- Orientation:
- Plus strand
Genomic View for FARP1 Gene
Genes around FARP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 13q32.2 by Ensembl
- 13q32.2 by Entrez Gene
- 13q32.2 by HGNC
FARP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FARP1 Gene
Proteins for FARP1 Gene
-
Protein details for FARP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y4F1-FARP1_HUMAN
- Recommended name:
- FERM, RhoGEF and pleckstrin domain-containing protein 1
- Protein Accession:
- Q9Y4F1
- Q5JVI9
- Q6IQ29
Protein attributes for FARP1 Gene
- Size:
- 1045 amino acids
- Molecular mass:
- 118633 Da
- Quaternary structure:
-
- Interacts with CADM1. Interacts with RAC1 (By similarity).
Protein Expression for FARP1 Gene
Post-translational modifications for FARP1 Gene
Other Protein References for FARP1 Gene
Antibody Products
- Novus Biologicals Antibodies for FARP1
- Invitrogen Antibodies for FARP1
- antibodies-online Antibodies for FARP1: See all 53
- GeneTex FARP1 antibody for FARP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for FARP1
Protein Products
-
OriGene Purified Proteins for FARP1
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- antibodies-online Proteins for FARP1: See all 5
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Assay Products
No data available for DME Specific Peptides for FARP1 Gene
Domains & Families for FARP1 Gene
Gene Families for FARP1 Gene
Protein Domains for FARP1 Gene
Suggested Antigen Peptide Sequences for FARP1 Gene
- GenScript: Design optimal peptide antigens:
-
- Pleckstrin homology domain-containing family C member 2 (FARP1_HUMAN)
- FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (Chondrocyte-derived) (Q5JV91_HUMAN)
- FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (Chondrocyte-derived) (Q5JV94_HUMAN)
- FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (Chondrocyte-derived) (Q5JVI9_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9Y4F1UniProtKB/Swiss-Prot:
FARP1_HUMAN :- Intramolecular interaction between the DH domain and the PH domains can stabilize the protein in an autoinhibited conformation.
- Domain:
-
- Intramolecular interaction between the DH domain and the PH domains can stabilize the protein in an autoinhibited conformation.
Function for FARP1 Gene
Molecular function for FARP1 Gene
- UniProtKB/Swiss-Prot Function:
- Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity).
- UniProtKB/Swiss-Prot Induction:
- Up-regulated in response to cAMP in cultured embryonic chondrocytes.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | TAS,IEA | 9425278 |
| GO:0008092 | cytoskeletal protein binding | IEA | -- |
| GO:0030676 | Rac guanyl-nucleotide exchange factor activity | ISS,IEA | -- |
| GO:0048365 | Rac GTPase binding | IEA | -- |
Phenotypes for FARP1 Gene
- GenomeRNAi human phenotypes for FARP1:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Decreased NF-kappaB reporter expression
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased viability after Maraba virus infection
- Increased G1 DNA content
- G0/1 arrest
- Decreased vaccinia virus (VACV-LREV ) gene expression
Animal Model Products
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ViGene Biosciences lentiviral particle packaged cDNA for FARP1 gene
-
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CRISPR Products
-
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-
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miRNA for FARP1 Gene
- miRTarBase miRNAs that target FARP1
miRNA Products
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Inhibitory RNA Products
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-
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Cell Line Products
-
Horizon Cell Lines for FARP1
-
ViGene Biosciences adenoviral particle packaged cDNA for FARP1 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FARP1 Gene
Localization for FARP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FARP1 Gene
- Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell junction, synapse, synaptosome. Cytoplasm, cytosol. Cell projection, filopodium. Cell projection, dendrite. Cell projection, dendritic spine. Note=Recruited to the cell membrane via interaction with CADM1. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| cytosol | 5 |
| plasma membrane | 4 |
| nucleus | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | ISS,IEA | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for FARP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of RhoA activity | ||
Pathways by source for FARP1 Gene
1 BioSystems pathway for FARP1 Gene
Interacting Proteins for FARP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007416 | synapse assembly | ISS,IEA | -- |
| GO:0010923 | negative regulation of phosphatase activity | IDA | 19389623 |
| GO:0035023 | regulation of Rho protein signal transduction | IEA | -- |
| GO:0043547 | positive regulation of GTPase activity | IEA | -- |
No data available for SIGNOR curated interactions for FARP1 Gene
Drugs & Compounds for FARP1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| cyclic amp | Experimental | Pharma | 0 |
Transcripts for FARP1 Gene
mRNA/cDNA for FARP1 Gene
- (6) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (468) Selected AceView cDNA sequences:
- (42) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FARP1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FARP1
-
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miRNA Products
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Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for FARP1 gene
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
| ExUns: | 22b | ^ | 23a | · | 23b | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32a | · | 32b | ^ | 33 | ^ | 34 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||
| SP8: |
Expression for FARP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Frontal cortex (8.6), Brain (8.6), and Fetal ovary (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FARP1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of FARP1 Gene:
FARP1SOURCE GeneReport for Unigene cluster for FARP1 Gene:
Hs.403917mRNA Expression by UniProt/SwissProt for FARP1 Gene:
Q9Y4F1-FARP1_HUMAN
Tissue specificity:
Detected in cAMP-treated chondrocytes, but not in untreated chondrocytes. Detected in fetal brain, heart and spleen, and in adult testis, kidney and lung.
Evidence on tissue expression from TISSUES for FARP1 Gene
- Nervous system(4.8)
- Skin(4.4)
- Liver(4.2)
- Lung(2.4)
Primer Products
-
OriGene qPCR primer pairs for FARP1
-
OriGene qPCR primer pairs and template standards for FARP1
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FARP1 Gene
Orthologs for FARP1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FARP1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FARP1 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FARP1 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | FARP1 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FARP1 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Farp1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Farp1 34 16 35 |
|
||
| chicken (Gallus gallus) |
Aves | FARP1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FARP1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | farp1 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | farp1 35 |
|
OneToOne | |
| LOC100329707 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10646 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Cdep 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | frm-3 36 |
|
|
|
| F52D10.6 36 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.8849 35 |
|
OneToMany |
- Species where no ortholog for FARP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FARP1 Gene
(18) SIMAP similar genes for FARP1 Gene using alignment to 6 proteins:
Variants for FARP1 Gene
| SNP ID | Clin | Chr 13 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_035851 | A breast cancer sample | ||||
| rs1000016556 | -- | 98,231,028(+) | ATTCA(C/T)TACCA | intron-variant | |
| rs1000020273 | -- | 98,147,688(+) | TCTTT(C/T)TGAAA | intron-variant | |
| rs1000040922 | -- | 98,380,589(+) | CAAAA(-/T)TTTTT | intron-variant | |
| rs1000063631 | -- | 98,362,176(+) | GGAGG(A/C)TTGCC | intron-variant |
Residual Variation Intolerance Score:
33.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.63;
72.65% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FARP1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FARP1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FARP1 Gene
Disorders for FARP1 Gene
Relevant External Links for FARP1
No disorders were found for FARP1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FARP1 Gene
Publications for FARP1 Gene
- Molecular cloning and characterization of CDEP, a novel human protein containing the ezrin-like domain of the band 4.1 superfamily and the Dbl homology domain of rho guanine nucleotide exchange factors. (PMID: 9425278) Koyano Y. … Kato Y. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 22 64
- Structural basis for autoinhibition of the guanine nucleotide exchange factor FARP2. (PMID: 23375260) He X. … Zhang X. (Structure 2013) 3 4 64
- Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney S.J. … . (Mol. Psychiatry 2011) 3 46 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease. (PMID: 20708005) Chalasani N. … Rotter J.I. (Gastroenterology 2010) 3 46 64
Products for FARP1 Gene
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- antibodies-online Antibodies for FARP1: See all 53
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- antibodies-online Proteins for FARP1: See all 5
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- GeneTex FARP1 antibody for FARP1
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- ViGene Biosciences adenoviral particle packaged cDNA for FARP1 gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FARP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
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