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Aliases for FAR2 Gene

Aliases for FAR2 Gene

  • Fatty Acyl-CoA Reductase 2 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 10E, Member 2 2 3
  • Male Sterility Domain-Containing Protein 1 3 4
  • MLSTD1 3 4
  • Male Sterility Domain Containing 1 2
  • Epididymis Secretory Protein Li 81 3
  • EC 1.2.1.n2 58
  • EC 1.2.1.84 4
  • HEL-S-81 3
  • SDR10E2 3

External Ids for FAR2 Gene

Previous HGNC Symbols for FAR2 Gene

  • MLSTD1

Previous GeneCards Identifiers for FAR2 Gene

  • GC12P029268
  • GC12P029376
  • GC12P029302

Summaries for FAR2 Gene

Entrez Gene Summary for FAR2 Gene

  • This gene belongs to the short chain dehydrogenase/reductase superfamily. It encodes a reductase enzyme involved in the first step of wax biosynthesis wherein fatty acids are converted to fatty alcohols. The encoded peroxisomal protein utilizes saturated fatty acids of 16 or 18 carbons as preferred substrates. Alternatively spliced transcript variants have been observed for this gene. Related pseudogenes have been identified on chromosomes 2, 14 and 22. [provided by RefSeq, Nov 2012]

GeneCards Summary for FAR2 Gene

FAR2 (Fatty Acyl-CoA Reductase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Peroxisome. GO annotations related to this gene include NAD binding and coenzyme binding. An important paralog of this gene is FAR1.

UniProtKB/Swiss-Prot for FAR2 Gene

  • Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates (PubMed:15220348). It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates (By similarity).

Additional gene information for FAR2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAR2 Gene

Genomics for FAR2 Gene

Regulatory Elements for FAR2 Gene

Enhancers for FAR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H029240 1.6 FANTOM5 Ensembl ENCODE 22.7 +93.4 93357 3 HDAC1 PKNOX1 BMI1 FEZF1 BATF RAD21 YY1 ZNF766 GATA2 ELK1 LOC100506606 FAR2 GC12P029213 ENSG00000275476
GH12H029101 1.3 FANTOM5 Ensembl ENCODE 12.5 -45.4 -45435 3 IRF2 ETV1 BATF EED STAT2 ATF7 ETV6 RUNX3 IKZF2 CREM FAR2 LOC100506606 GC12P029085 ENSG00000257258
GH12H029206 1.1 FANTOM5 Ensembl ENCODE 12.4 +59.2 59237 3 POLR2A MAX ZSCAN29 MYC FAR2 LOC100506606 GC12P029213 PIR55591
GH12H029220 0.6 ENCODE 18.6 +71.9 71901 0 CC2D1A NFIC KLF1 FOXK2 NRF1 CEBPB NR2C2 FAR2 LOC100506606 GC12P029213 ENSG00000275476
GH12H029040 1 Ensembl ENCODE 10.7 -106.9 -106930 3 PKNOX1 ZFP37 FEZF1 ZEB2 DPF2 ZNF217 HIC1 JUND ZNF366 POLR2A FAR2 LOC100506606 LOC101928735 GC12P029085
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAR2 on UCSC Golden Path with GeneCards custom track

Promoters for FAR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000050365 297 1801 GLI4 ZNF121 GLIS2 KLF7 RUNX3 SP3 REST CBX8 GLIS1 PRDM4

Genomic Location for FAR2 Gene

Chromosome:
12
Start:
29,149,003 bp from pter
End:
29,340,980 bp from pter
Size:
191,978 bases
Orientation:
Plus strand

Genomic View for FAR2 Gene

Genes around FAR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAR2 Gene

Proteins for FAR2 Gene

  • Protein details for FAR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96K12-FACR2_HUMAN
    Recommended name:
    Fatty acyl-CoA reductase 2
    Protein Accession:
    Q96K12
    Secondary Accessions:
    • F8VV73
    • Q9H0D5
    • Q9NVW8

    Protein attributes for FAR2 Gene

    Size:
    515 amino acids
    Molecular mass:
    59438 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAR2 Gene

Selected DME Specific Peptides for FAR2 Gene

Q96K12:
  • IARSQMARN
  • SYFRASST
  • FNFDVRQL
  • TGATGFLGKVL

Post-translational modifications for FAR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for FAR2 Gene

Gene Families for FAR2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FAR2 Gene

Suggested Antigen Peptide Sequences for FAR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96K12

UniProtKB/Swiss-Prot:

FACR2_HUMAN :
  • Belongs to the fatty acyl-CoA reductase family.
Family:
  • Belongs to the fatty acyl-CoA reductase family.
genes like me logo Genes that share domains with FAR2: view

Function for FAR2 Gene

Molecular function for FAR2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A long-chain acyl-CoA + 2 NADPH = CoA + a long-chain alcohol + 2 NADP(+).
UniProtKB/Swiss-Prot Function:
Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates (PubMed:15220348). It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates (By similarity).

Enzyme Numbers (IUBMB) for FAR2 Gene

Phenotypes From GWAS Catalog for FAR2 Gene

Gene Ontology (GO) - Molecular Function for FAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA,TAS --
GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity IEA,IDA 15220348
genes like me logo Genes that share ontologies with FAR2: view
genes like me logo Genes that share phenotypes with FAR2: view

Animal Models for FAR2 Gene

MGI Knock Outs for FAR2:
  • Far2 tm2b(KOMP)Wtsi

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAR2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAR2 Gene

Localization for FAR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAR2 Gene

Peroxisome membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAR2 gene
Compartment Confidence
peroxisome 5
nucleus 2
cytosol 2
golgi apparatus 2
mitochondrion 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome ISS --
GO:0005778 peroxisomal membrane IEA --
GO:0005779 integral component of peroxisomal membrane IDA 24108123
GO:0005782 peroxisomal matrix TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with FAR2: view

Pathways & Interactions for FAR2 Gene

genes like me logo Genes that share pathways with FAR2: view

Pathways by source for FAR2 Gene

1 KEGG pathway for FAR2 Gene

Interacting Proteins for FAR2 Gene

Gene Ontology (GO) - Biological Process for FAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0010025 wax biosynthetic process IBA,TAS --
GO:0035336 long-chain fatty-acyl-CoA metabolic process IDA 15220348
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with FAR2: view

No data available for SIGNOR curated interactions for FAR2 Gene

Drugs & Compounds for FAR2 Gene

(7) Drugs for FAR2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Isopropyl alcohol Approved Pharma 0
1-Butanol Experimental Pharma 0
Hexadecanal Experimental Pharma 0
Hexanoyl-CoA Experimental Pharma 0
Propanoyl-CoA Experimental Pharma 0

(43) Additional Compounds for FAR2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with FAR2: view

Transcripts for FAR2 Gene

Unigene Clusters for FAR2 Gene

Fatty acyl CoA reductase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAR2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FAR2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2: -
SP3: - - - -
SP4: - - - - -
SP5: -
SP6:

Relevant External Links for FAR2 Gene

GeneLoc Exon Structure for
FAR2
ECgene alternative splicing isoforms for
FAR2

Expression for FAR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAR2 Gene

mRNA differential expression in normal tissues according to GTEx for FAR2 Gene

This gene is overexpressed in Whole Blood (x8.4).

Protein differential expression in normal tissues from HIPED for FAR2 Gene

This gene is overexpressed in Lung (56.8) and Platelet (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAR2 Gene



Protein tissue co-expression partners for FAR2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FAR2 Gene:

FAR2

SOURCE GeneReport for Unigene cluster for FAR2 Gene:

Hs.728955

Evidence on tissue expression from TISSUES for FAR2 Gene

  • Heart(4.2)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with FAR2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAR2 Gene

Orthologs for FAR2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FAR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAR2 33 34
  • 99.61 (n)
dog
(Canis familiaris)
Mammalia FAR2 33 34
  • 91.33 (n)
cow
(Bos Taurus)
Mammalia FAR2 33 34
  • 88.93 (n)
mouse
(Mus musculus)
Mammalia Far2 33 16 34
  • 84.01 (n)
rat
(Rattus norvegicus)
Mammalia Far2 33
  • 83.43 (n)
oppossum
(Monodelphis domestica)
Mammalia FAR2 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAR2 34
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAR2 33 34
  • 67.96 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 62 (a)
OneToMany
-- 34
  • 52 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii FAR2 34
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5065 33 34
  • 48.37 (n)
CG12268 34
  • 34 (a)
ManyToMany
CG14893 34
  • 34 (a)
ManyToMany
CG17560 34
  • 33 (a)
ManyToMany
CG4020 34
  • 33 (a)
ManyToMany
CG10096 34
  • 32 (a)
ManyToMany
CG10097 34
  • 32 (a)
ManyToMany
CG17562 34
  • 32 (a)
ManyToMany
CG13091 34
  • 31 (a)
ManyToMany
CG1441 34
  • 31 (a)
ManyToMany
CG30427 34
  • 31 (a)
ManyToMany
CG8306 34
  • 31 (a)
ManyToMany
CG1443 34
  • 30 (a)
ManyToMany
CG18031 34
  • 28 (a)
ManyToMany
CG4770 34
  • 28 (a)
ManyToMany
CG34342 34
  • 26 (a)
ManyToMany
CG8303 34
  • 25 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009690 33
  • 39.47 (n)
worm
(Caenorhabditis elegans)
Secernentea fard-1 33 34
  • 48.99 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons MS2 33
  • 45.34 (n)
rice
(Oryza sativa)
Liliopsida Os03g0167600 33
  • 44.59 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
ManyToMany
-- 34
  • 34 (a)
ManyToMany
CSA.10130 34
  • 33 (a)
ManyToMany
-- 34
  • 32 (a)
ManyToMany
Species where no ortholog for FAR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FAR2 Gene

ENSEMBL:
Gene Tree for FAR2 (if available)
TreeFam:
Gene Tree for FAR2 (if available)

Paralogs for FAR2 Gene

Paralogs for FAR2 Gene

(1) SIMAP similar genes for FAR2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FAR2: view

Variants for FAR2 Gene

Sequence variations from dbSNP and Humsavar for FAR2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000021935 -- 29,260,281(+) GGCAA(G/T)AGGTA intron-variant
rs1000031571 -- 29,193,436(+) ACTGA(C/T)CATTT intron-variant
rs1000069550 -- 29,276,508(+) ATATG(G/T)AATCT intron-variant
rs1000122874 -- 29,284,618(+) AGACA(A/G)TAGAA intron-variant
rs1000126389 -- 29,230,080(+) TGACC(A/G)AATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAR2 Gene

Variant ID Type Subtype PubMed ID
esv2762969 CNV loss 21179565
esv33168 CNV gain 17666407
esv33218 CNV gain 17666407
nsv1113470 CNV deletion 24896259
nsv437739 CNV loss 16327808
nsv477212 CNV novel sequence insertion 20440878
nsv819469 CNV gain 19587683
nsv951345 CNV duplication 24416366
nsv975465 CNV duplication 23825009

Variation tolerance for FAR2 Gene

Residual Variation Intolerance Score: 19.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAR2 Gene

Disorders for FAR2 Gene

Genatlas disease for FAR2 Gene

familial amyloidosis,renal,Ostertag type (lysozyme deposit)

Relevant External Links for FAR2

Genetic Association Database (GAD)
FAR2
Human Genome Epidemiology (HuGE) Navigator
FAR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAR2
genes like me logo Genes that share disorders with FAR2: view

No data available for MalaCards and UniProtKB/Swiss-Prot for FAR2 Gene

Publications for FAR2 Gene

  1. Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions. (PMID: 15220348) Cheng JB … Russell DW (The Journal of biological chemistry 2004) 2 3 4 60
  2. Topogenesis and homeostasis of fatty acyl-CoA reductase 1. (PMID: 24108123) Honsho M … Fujiki Y (The Journal of biological chemistry 2013) 3 4 60
  3. New gene functions in megakaryopoiesis and platelet formation. (PMID: 22139419) Gieger C … Soranzo N (Nature 2011) 3 45 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  5. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B … Oppermann U (Chemico-biological interactions 2009) 2 3 60

Products for FAR2 Gene

Sources for FAR2 Gene

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