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Aliases for FAR2 Gene

Aliases for FAR2 Gene

  • Fatty Acyl CoA Reductase 2 2 3
  • Male Sterility Domain-Containing Protein 1 3 4
  • EC 1.2.1.n2 4 63
  • MLSTD1 3 4
  • Short Chain Dehydrogenase/Reductase Family 10E, Member 2 3
  • Short Chain Dehydrogenase/Reductase Family 10E 2
  • Male Sterility Domain Containing 1 2
  • Fatty Acyl-CoA Reductase 2 3
  • Member 2 2
  • SDR10E2 3

External Ids for FAR2 Gene

Previous HGNC Symbols for FAR2 Gene

  • MLSTD1

Previous GeneCards Identifiers for FAR2 Gene

  • GC12P029268
  • GC12P029376
  • GC12P029302

Summaries for FAR2 Gene

Entrez Gene Summary for FAR2 Gene

  • This gene belongs to the short chain dehydrogenase/reductase superfamily. It encodes a reductase enzyme involved in the first step of wax biosynthesis wherein fatty acids are converted to fatty alcohols. The encoded peroxisomal protein utilizes saturated fatty acids of 16 or 18 carbons as preferred substrates. Alternatively spliced transcript variants have been observed for this gene. Related pseudogenes have been identified on chromosomes 2, 14 and 22. [provided by RefSeq, Nov 2012]

GeneCards Summary for FAR2 Gene

FAR2 (Fatty Acyl CoA Reductase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include fatty-acyl-CoA reductase (alcohol-forming) activity and long-chain-fatty-acyl-CoA reductase activity. An important paralog of this gene is FAR1.

UniProtKB/Swiss-Prot for FAR2 Gene

  • Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. The preferred substrates are C16, C18, C18:1 and C18:2 but low activity can be observed with C10-C14 substrates.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAR2 Gene

Genomics for FAR2 Gene

Regulatory Elements for FAR2 Gene

Genomic Location for FAR2 Gene

Start:
29,149,003 bp from pter
End:
29,340,980 bp from pter
Size:
191,978 bases
Orientation:
Plus strand

Genomic View for FAR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAR2 Gene

Proteins for FAR2 Gene

  • Protein details for FAR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96K12-FACR2_HUMAN
    Recommended name:
    Fatty acyl-CoA reductase 2
    Protein Accession:
    Q96K12
    Secondary Accessions:
    • F8VV73
    • Q9H0D5
    • Q9NVW8

    Protein attributes for FAR2 Gene

    Size:
    515 amino acids
    Molecular mass:
    59438 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAR2 Gene

Proteomics data for FAR2 Gene at MOPED

Selected DME Specific Peptides for FAR2 Gene

Post-translational modifications for FAR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAR2 Gene

Domains for FAR2 Gene

Gene Families for FAR2 Gene

HGNC:
  • SDRA :Short chain dehydrogenase/reductase superfamily / Atypical members

Protein Domains for FAR2 Gene

Suggested Antigen Peptide Sequences for FAR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96K12

UniProtKB/Swiss-Prot:

FACR2_HUMAN :
  • Q96K12
Family:
  • Belongs to the fatty acyl-CoA reductase family.
genes like me logo Genes that share domains with FAR2: view

Function for FAR2 Gene

Molecular function for FAR2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Hexadecanal + CoA + NADP(+) = hexadecanoyl-CoA + NADPH
UniProtKB/Swiss-Prot Function: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. The preferred substrates are C16, C18, C18:1 and C18:2 but low activity can be observed with C10-C14 substrates.

Enzyme Numbers (IUBMB) for FAR2 Gene

Gene Ontology (GO) - Molecular Function for FAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor --
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor --
GO:0050062 long-chain-fatty-acyl-CoA reductase activity IEA --
genes like me logo Genes that share ontologies with FAR2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAR2

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FAR2 Gene

Localization for FAR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAR2 Gene

Peroxisome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Peroxisome in cells expressing low levels of the protein. Peroxisome and endoplasmic reticulum in cells expressing high levels of the protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAR2 Gene COMPARTMENTS Subcellular localization image for FAR2 gene
Compartment Confidence
endoplasmic reticulum 5
peroxisome 5
cytosol 2
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome ISS --
GO:0005778 peroxisomal membrane IEA --
GO:0005782 peroxisomal matrix TAS --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with FAR2: view

Pathways for FAR2 Gene

genes like me logo Genes that share pathways with FAR2: view

Pathways by source for FAR2 Gene

Interacting Proteins for FAR2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000182377%0d%0a9606.ENSP00000264167%0d%0a9606.ENSP00000355607%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000182377 for FAR2 Gene via STRING

Gene Ontology (GO) - Biological Process for FAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006694 steroid biosynthetic process --
GO:0008611 ether lipid biosynthetic process TAS --
GO:0009058 biosynthetic process --
GO:0035336 long-chain fatty-acyl-CoA metabolic process IDA 15220348
GO:0044255 cellular lipid metabolic process TAS --
genes like me logo Genes that share ontologies with FAR2: view

Compounds for FAR2 Gene

(48) HMDB Compounds for FAR2 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with FAR2: view

Transcripts for FAR2 Gene

Unigene Clusters for FAR2 Gene

Fatty acyl CoA reductase 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAR2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAR2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2: -
SP3: - - - -
SP4: - - - - -
SP5: -
SP6:

Relevant External Links for FAR2 Gene

GeneLoc Exon Structure for
FAR2
ECgene alternative splicing isoforms for
FAR2

Expression for FAR2 Gene

mRNA expression in normal human tissues for FAR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAR2 Gene

This gene is overexpressed in Whole Blood (8.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAR2 Gene

SOURCE GeneReport for Unigene cluster for FAR2 Gene Hs.728955

genes like me logo Genes that share expressions with FAR2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FAR2 Gene

Orthologs for FAR2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FAR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAR2 35
  • 99.61 (n)
  • 99.61 (a)
FAR2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAR2 35
  • 88.93 (n)
  • 91.26 (a)
FAR2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAR2 35
  • 91.33 (n)
  • 92.62 (a)
FAR2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Far2 35
  • 84.01 (n)
  • 87.7 (a)
Far2 16
Far2 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAR2 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAR2 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Far2 35
  • 83.43 (n)
  • 87.57 (a)
chicken
(Gallus gallus)
Aves FAR2 35
  • 67.96 (n)
  • 63.62 (a)
FAR2 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 62 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii FAR2 36
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009690 35
  • 39.47 (n)
  • 25.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10096 36
  • 32 (a)
ManyToMany
CG10097 36
  • 32 (a)
ManyToMany
CG12268 36
  • 34 (a)
ManyToMany
CG13091 36
  • 31 (a)
ManyToMany
CG1441 36
  • 31 (a)
ManyToMany
CG1443 36
  • 30 (a)
ManyToMany
CG14893 36
  • 34 (a)
ManyToMany
CG17560 36
  • 33 (a)
ManyToMany
CG17562 36
  • 32 (a)
ManyToMany
CG18031 36
  • 28 (a)
ManyToMany
CG30427 36
  • 31 (a)
ManyToMany
CG34342 36
  • 26 (a)
ManyToMany
CG4020 36
  • 33 (a)
ManyToMany
CG4770 36
  • 28 (a)
ManyToMany
CG5065 35
  • 48.37 (n)
  • 39.59 (a)
CG5065 36
  • 31 (a)
ManyToMany
CG8303 36
  • 25 (a)
ManyToMany
CG8306 36
  • 31 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea fard-1 35
  • 48.99 (n)
  • 37.17 (a)
fard-1 36
  • 33 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons MS2 35
  • 45.34 (n)
  • 29.82 (a)
rice
(Oryza sativa)
Liliopsida Os03g0167600 35
  • 44.59 (n)
  • 31.31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
CSA.10130 36
  • 33 (a)
ManyToMany
Species with no ortholog for FAR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FAR2 Gene

ENSEMBL:
Gene Tree for FAR2 (if available)
TreeFam:
Gene Tree for FAR2 (if available)

Paralogs for FAR2 Gene

Paralogs for FAR2 Gene

Selected SIMAP similar genes for FAR2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FAR2: view

Variants for FAR2 Gene

Sequence variations from dbSNP and Humsavar for FAR2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs737160 -- 29,276,079(+) ACCAA(C/T)TGTGA intron-variant
rs766445 -- 29,260,560(+) accca(A/G)tgcat intron-variant
rs766446 -- 29,260,609(+) ttgag(C/G)acagg intron-variant
rs766764 -- 29,243,885(+) AATAA(A/G)AACCT intron-variant
rs889927 -- 29,223,453(+) CAGGT(A/C)ATCAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAR2 Gene

Variant ID Type Subtype PubMed ID
esv33218 CNV Gain 17666407

Relevant External Links for FAR2 Gene

HapMap Linkage Disequilibrium report
FAR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAR2 Gene

Disorders for FAR2 Gene

(1) University of Copenhagen DISEASES for FAR2 Gene

Genatlas disease for FAR2 Gene

familial amyloidosis,renal,Ostertag type (lysozyme deposit)

Relevant External Links for FAR2

Genetic Association Database (GAD)
FAR2
Human Genome Epidemiology (HuGE) Navigator
FAR2
genes like me logo Genes that share disorders with FAR2: view

No data available for UniProtKB/Swiss-Prot for FAR2 Gene

Publications for FAR2 Gene

  1. Mammalian wax biosynthesis: I. Identification of two fatty acyl- coenzyme A reductases with different substrate specificities and tissue distributions. (PMID: 15220348) Cheng J.B. … Russell D.W. (J. Biol. Chem. 2004) 2 3 4
  2. Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family. (PMID: 15220349) Cheng J.B. … Russell D.W. (J. Biol. Chem. 2004) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  5. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3

Products for FAR2 Gene

Sources for FAR2 Gene

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