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Aliases for FAR2 Gene

Aliases for FAR2 Gene

  • Fatty Acyl-CoA Reductase 2 2 3 5
  • Male Sterility Domain-Containing Protein 1 3 4
  • EC 1.2.1.n2 4 63
  • MLSTD1 3 4
  • Short Chain Dehydrogenase/Reductase Family 10E, Member 2 3
  • Short Chain Dehydrogenase/Reductase Family 10E 2
  • Male Sterility Domain Containing 1 2
  • Epididymis Secretory Protein Li 81 3
  • Fatty Acyl CoA Reductase 2 3
  • Member 2 2
  • HEL-S-81 3
  • SDR10E2 3

External Ids for FAR2 Gene

Previous HGNC Symbols for FAR2 Gene

  • MLSTD1

Previous GeneCards Identifiers for FAR2 Gene

  • GC12P029268
  • GC12P029376
  • GC12P029302

Summaries for FAR2 Gene

Entrez Gene Summary for FAR2 Gene

  • This gene belongs to the short chain dehydrogenase/reductase superfamily. It encodes a reductase enzyme involved in the first step of wax biosynthesis wherein fatty acids are converted to fatty alcohols. The encoded peroxisomal protein utilizes saturated fatty acids of 16 or 18 carbons as preferred substrates. Alternatively spliced transcript variants have been observed for this gene. Related pseudogenes have been identified on chromosomes 2, 14 and 22. [provided by RefSeq, Nov 2012]

GeneCards Summary for FAR2 Gene

FAR2 (Fatty Acyl-CoA Reductase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Peroxisome. GO annotations related to this gene include NAD binding and coenzyme binding. An important paralog of this gene is FAR1.

UniProtKB/Swiss-Prot for FAR2 Gene

  • Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. The preferred substrates are C16, C18, C18:1 and C18:2 but low activity can be observed with C10-C14 substrates.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAR2 Gene

Genomics for FAR2 Gene

Regulatory Elements for FAR2 Gene

Enhancers for FAR2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAR2 on UCSC Golden Path with GeneCards custom track

Promoters for FAR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FAR2 Gene

29,149,003 bp from pter
29,340,980 bp from pter
191,978 bases
Plus strand

Genomic View for FAR2 Gene

Genes around FAR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAR2 Gene

Proteins for FAR2 Gene

  • Protein details for FAR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fatty acyl-CoA reductase 2
    Protein Accession:
    Secondary Accessions:
    • F8VV73
    • Q9H0D5
    • Q9NVW8

    Protein attributes for FAR2 Gene

    515 amino acids
    Molecular mass:
    59438 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAR2 Gene


neXtProt entry for FAR2 Gene

Proteomics data for FAR2 Gene at MOPED

Selected DME Specific Peptides for FAR2 Gene

Post-translational modifications for FAR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for FAR2 Gene

Gene Families for FAR2 Gene

Protein Domains for FAR2 Gene

Suggested Antigen Peptide Sequences for FAR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the fatty acyl-CoA reductase family.
  • Belongs to the fatty acyl-CoA reductase family.
genes like me logo Genes that share domains with FAR2: view

Function for FAR2 Gene

Molecular function for FAR2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hexadecanal + CoA + NADP(+) = hexadecanoyl-CoA + NADPH.
UniProtKB/Swiss-Prot Function:
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. The preferred substrates are C16, C18, C18:1 and C18:2 but low activity can be observed with C10-C14 substrates.

Enzyme Numbers (IUBMB) for FAR2 Gene

genes like me logo Genes that share phenotypes with FAR2: view

Animal Models for FAR2 Gene

MGI Knock Outs for FAR2:
  • Far2 tm2b(KOMP)Wtsi

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAR2 Gene

Localization for FAR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAR2 Gene

Peroxisome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Peroxisome in cells expressing low levels of the protein. Peroxisome and endoplasmic reticulum in cells expressing high levels of the protein.

Subcellular locations from

Jensen Localization Image for FAR2 Gene COMPARTMENTS Subcellular localization image for FAR2 gene
Compartment Confidence
peroxisome 5
endoplasmic reticulum 3
cytosol 2
golgi apparatus 2
nucleus 2
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome ISS --
GO:0005778 peroxisomal membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAR2: view

Pathways & Interactions for FAR2 Gene

genes like me logo Genes that share pathways with FAR2: view

Pathways by source for FAR2 Gene

1 KEGG pathway for FAR2 Gene

Interacting Proteins for FAR2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000182377 for FAR2 Gene via STRING

Gene Ontology (GO) - Biological Process for FAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0044255 cellular lipid metabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with FAR2: view

No data available for SIGNOR curated interactions for FAR2 Gene

Drugs & Compounds for FAR2 Gene

(6) Drugs for FAR2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
1-Butanol Experimental Pharma 0
1-Proponol Experimental Pharma 0
Dodecanol Experimental Pharma 0
Hexadecanal Experimental Pharma 0
Propionyl-CoA Experimental Pharma 0

(44) Additional Compounds for FAR2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
genes like me logo Genes that share compounds with FAR2: view

Transcripts for FAR2 Gene

Unigene Clusters for FAR2 Gene

Fatty acyl CoA reductase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAR2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP2: -
SP3: - - - -
SP4: - - - - -
SP5: -

Relevant External Links for FAR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAR2 Gene

mRNA expression in normal human tissues for FAR2 Gene

mRNA differential expression in normal tissues according to GTEx for FAR2 Gene

This gene is overexpressed in Whole Blood (x8.4).

Protein differential expression in normal tissues from HIPED for FAR2 Gene

This gene is overexpressed in Lung (56.8) and Platelet (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAR2 Gene

SOURCE GeneReport for Unigene cluster for FAR2 Gene Hs.728955

genes like me logo Genes that share expression patterns with FAR2: view

Protein tissue co-expression partners for FAR2 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for FAR2 Gene

Orthologs for FAR2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FAR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAR2 35
  • 88.93 (n)
  • 91.26 (a)
FAR2 36
  • 91 (a)
(Canis familiaris)
Mammalia FAR2 35
  • 91.33 (n)
  • 92.62 (a)
FAR2 36
  • 93 (a)
(Mus musculus)
Mammalia Far2 35
  • 84.01 (n)
  • 87.7 (a)
Far2 16
Far2 36
  • 87 (a)
(Pan troglodytes)
Mammalia FAR2 35
  • 99.61 (n)
  • 99.61 (a)
FAR2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Far2 35
  • 83.43 (n)
  • 87.57 (a)
(Monodelphis domestica)
Mammalia FAR2 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia FAR2 36
  • 49 (a)
(Gallus gallus)
Aves FAR2 35
  • 67.96 (n)
  • 63.62 (a)
FAR2 36
  • 59 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 62 (a)
-- 36
  • 52 (a)
(Danio rerio)
Actinopterygii FAR2 36
  • 61 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009690 35
  • 39.47 (n)
  • 25.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5065 35
  • 48.37 (n)
  • 39.59 (a)
CG10096 36
  • 32 (a)
CG10097 36
  • 32 (a)
CG12268 36
  • 34 (a)
CG13091 36
  • 31 (a)
CG1441 36
  • 31 (a)
CG1443 36
  • 30 (a)
CG14893 36
  • 34 (a)
CG17560 36
  • 33 (a)
CG17562 36
  • 32 (a)
CG18031 36
  • 28 (a)
CG30427 36
  • 31 (a)
CG34342 36
  • 26 (a)
CG4020 36
  • 33 (a)
CG4770 36
  • 28 (a)
CG5065 36
  • 31 (a)
CG8303 36
  • 25 (a)
CG8306 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea fard-1 35
  • 48.99 (n)
  • 37.17 (a)
fard-1 36
  • 33 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons MS2 35
  • 45.34 (n)
  • 29.82 (a)
(Oryza sativa)
Liliopsida Os03g0167600 35
  • 44.59 (n)
  • 31.31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
-- 36
  • 34 (a)
-- 36
  • 34 (a)
CSA.10130 36
  • 33 (a)
Species with no ortholog for FAR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FAR2 Gene

Gene Tree for FAR2 (if available)
Gene Tree for FAR2 (if available)

Paralogs for FAR2 Gene

Paralogs for FAR2 Gene

(1) SIMAP similar genes for FAR2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FAR2: view

Variants for FAR2 Gene

Sequence variations from dbSNP and Humsavar for FAR2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_053801 -
VAR_053802 -
rs1989075 -- 29,263,481(+) TAGAA(A/G)TCAAC intron-variant
rs1991113 -- 29,239,070(+) aagga(C/G)cttaa intron-variant
rs1991114 -- 29,239,149(+) TTGCT(G/T)TATTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAR2 Gene

Variant ID Type Subtype PubMed ID
esv33218 CNV Gain 17666407

Variation tolerance for FAR2 Gene

Residual Variation Intolerance Score: 19.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.19% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAR2 Gene

Disorders for FAR2 Gene

Genatlas disease for FAR2 Gene

familial amyloidosis,renal,Ostertag type (lysozyme deposit)

Relevant External Links for FAR2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FAR2: view

No data available for MalaCards and UniProtKB/Swiss-Prot for FAR2 Gene

Publications for FAR2 Gene

  1. Mammalian wax biosynthesis: I. Identification of two fatty acyl- coenzyme A reductases with different substrate specificities and tissue distributions. (PMID: 15220348) Cheng J.B. … Russell D.W. (J. Biol. Chem. 2004) 2 3 4 67
  2. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3
  3. Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family. (PMID: 15220349) Cheng J.B. … Russell D.W. (J. Biol. Chem. 2004) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. New gene functions in megakaryopoiesis and platelet formation. (PMID: 22139419) Gieger C. … Soranzo N. (Nature 2011) 3

Products for FAR2 Gene

Sources for FAR2 Gene