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FAR2 Gene

protein-coding   GIFtS: 54
GCID: GC12P029302

Fatty Acyl CoA Reductase 2

(Previous name: male sterility domain containing 1)
(Previous symbol: MLSTD1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fatty Acyl CoA Reductase 21 2     Short Chain Dehydrogenase/Reductase Family 10E1
MLSTD11 2 3     SDR10E22
Male Sterility Domain-Containing Protein 12 3     Fatty Acyl-CoA Reductase 22
EC 1.2.1.n23 8     Short Chain Dehydrogenase/Reductase Family 10E, Member 22
Male Sterility Domain Containing 11     A5
Member 21     AKR7A35

External Ids:    HGNC: 255311   Entrez Gene: 557112   Ensembl: ENSG000000647637   OMIM: 6084775   UniProtKB: Q96K123   

Export aliases for FAR2 gene to outside databases

Previous GC identifers: GC12P029268 GC12P029376 GC12P029145


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FAR2 Gene:
This gene belongs to the short chain dehydrogenase/reductase superfamily. It encodes a reductase enzyme involved
in the first step of wax biosynthesis wherein fatty acids are converted to fatty alcohols. The encoded
peroxisomal protein utilizes saturated fatty acids of 16 or 18 carbons as preferred substrates. Alternatively
spliced transcript variants have been observed for this gene. Related pseudogenes have been identified on
chromosomes 2, 14 and 22. (provided by RefSeq, Nov 2012)

GeneCards Summary for FAR2 Gene:
FAR2 (fatty acyl CoA reductase 2) is a protein-coding gene. GO annotations related to this gene include fatty-acyl-CoA reductase (alcohol-forming) activity and long-chain-fatty-acyl-CoA reductase activity. An important paralog of this gene is FAR1.

UniProtKB/Swiss-Prot: FACR2_HUMAN, Q96K12
Function: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. The preferred substrates are C16, C18,
C18:1 and C18:2 but low activity can be observed with C10-C14 substrates




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the FAR2 gene promoter:
         Nkx3-1 v4   NF-1   Pax-5   Pbx1a   Nkx3-1 v1   POU6F1 (c2)   Evi-1   MZF-1   Nkx3-1 v2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FAR2 promoter sequence
   Search Chromatin IP Primers for FAR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p11.22   Ensembl cytogenetic band:  12p11.22   HGNC cytogenetic band: 12p11.23

FAR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAR2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P029302:  view genomic region     (about GC identifiers)

Start:
29,302,036 bp from pter      End:
29,493,913 bp from pter
Size:
191,878 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FACR2_HUMAN, Q96K12 (See protein sequence)
Recommended Name: Fatty acyl-CoA reductase 2  
Size: 515 amino acids; 59438 Da
Secondary accessions: Q9H0D5 Q9NVW8

Explore the universe of human proteins at neXtProt for FAR2: NX_Q96K12

Explore proteomics data for FAR2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for FAR2 (Q96K12)
     FNFDVRQL  SYFRASST  IARSQMARN  TGATGFLGKVL 


    See FAR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001258712.1  NP_001258713.1  NP_060569.3  

    ENSEMBL proteins: 
     ENSP00000450117   ENSP00000443291   ENSP00000182377   ENSP00000449349   ENSP00000449436  
     ENSP00000449187   ENSP00000447467  
    Reactome Protein details: Q96K12

    FAR2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for FAR2

     
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    antibodies-online peptides for FAR2

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    antibodies-online antibodies for FAR2 (18 products) 

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    antibodies-online kits for FAR2 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SDRA: Short chain dehydrogenase/reductase superfamily / Atypical members

    3 InterPro protein domains:
     IPR026055 FAR
     IPR016040 NAD(P)-bd_dom
     IPR013120 Male_sterile_NAD-bd

    Graphical View of Domain Structure for InterPro Entry Q96K12

    ProtoNet protein and cluster: Q96K12

    1 Blocks protein domain: IPB013120 Male sterility C-terminal

    UniProtKB/Swiss-Prot: FACR2_HUMAN, Q96K12
    Similarity: Belongs to the fatty acyl-CoA reductase family


    Find genes that share domains with FAR2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FACR2_HUMAN, Q96K12
    Function: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. The preferred substrates are C16, C18,
    C18:1 and C18:2 but low activity can be observed with C10-C14 substrates
    Catalytic activity: Hexadecanal + CoA + NADP(+) = hexadecanoyl-CoA + NADPH

         Enzyme Number (IUBMB): EC 1.2.1.n21 2

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:00038543-beta-hydroxy-delta5-steroid dehydrogenase activity ----
    GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ----
    GO:0016620oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor ----
    GO:0050062long-chain-fatty-acyl-CoA reductase activity IEA--
         
    Find genes that share ontologies with FAR2           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Far2 (no phenotypes)

    Find genes that share phenotypes with FAR2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FAR2

    miRNA
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    Block miRNA regulation of human, mouse, rat FAR2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate FAR2:
    hsa-miR-3200-5p hsa-miR-202
    SwitchGear 3'UTR luciferase reporter plasmidFAR2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FAR2

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    GenScript: all cDNA clones in your preferred vector: FAR2 (NM_005306)
    Sino Biological Human cDNA Clone for FAR2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAR2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAR2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FACR2_HUMAN, Q96K12: Peroxisome membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum
    membrane; Multi-pass membrane protein (Potential). Note=Peroxisome in cells expressing low levels of the protein.
    Peroxisome and endoplasmic reticulum in cells expressing high levels of the protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    peroxisome5
    cytosol2
    golgi apparatus1
    lysosome1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005777peroxisome ISS--
    GO:0005778peroxisomal membrane IEA--
    GO:0005782peroxisomal matrix TAS--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with FAR2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FAR2 About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    2Peroxisomal lipid metabolism
    Peroxisomal lipid metabolism
    Plasmalogen biosynthesis0.00
    3Peroxisome
    Peroxisome


    Find genes that share SuperPaths with FAR2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for FAR2
        Plasmalogen biosynthesis


    1 Kegg Pathway  (Kegg details for FAR2):
        Peroxisome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAR2
    Interactions:

        Search GeneGlobe Interaction Network for FAR2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for FAR2 (ENSP000001823774) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGPSENSP000002641674STRING: ENSP00000264167
    GNPATENSP000003556074STRING: ENSP00000355607
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006694steroid biosynthetic process ----
    GO:0008611ether lipid biosynthetic process TAS--
    GO:0009058biosynthetic process ----
    GO:0035336long-chain fatty-acyl-CoA metabolic process IDA15220348
    GO:0044237cellular metabolic process ----

    Find genes that share ontologies with FAR2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAR2 (FACR2)

    Selected HMDB Compounds for FAR2 (see all 48)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexadecanol1-Cetanol (see all 82)36653-82-4--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    1-Undecanol1-Hendecanol (see all 25)112-42-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAR2 gene (3 alternative transcripts): 
    NM_001271783.1  NM_001271784.1  NM_018099.4  

    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000551451 ENST00000536681(uc001ris.4) ENST00000549080 ENST00000547411
    ENST00000550541 ENST00000182377(uc001rit.3 uc009zjm.3) ENST00000547116
    ENST00000552137 ENST00000551193 ENST00000547759
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate FAR2:
    hsa-miR-3200-5p hsa-miR-202
    SwitchGear 3'UTR luciferase reporter plasmidFAR2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: FAR2 (NM_005306)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAR2
      QuantiTect SYBR Green Assays in human, mouse, rat FAR2
      QuantiFast Probe-based Assays in human, mouse, rat FAR2

    Selected AceView cDNA sequences (see all 87):

    CR607516 BC018460 AI057451 AK027756 CK299276 AA489804 BC022267 BQ186333 
    AK129857 AA996057 BG741742 BM929835 N67205 NM_018099 BG697652 AL136843 
    BI560095 CB219012 BI862393 AU126704 CB998049 CB217880 AI025510 BI457875 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FAR2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                                                                                                                        
    SP2:                                                  -                                                                     
    SP3:                          -     -     -     -                                                                           
    SP4:                          -     -     -     -     -                                                                     
    SP5:                          -                                                                                             


    ECgene alternative splicing isoforms for FAR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAAAAATAT
    FAR2 Expression
    About this image


    FAR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Adipose (Muscoskeletal System)
             White adipocyte-like cells
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)
             Endothelial Cells Blood Brain Barrier
    FAR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAR2 Protein Expression
        Custom PCR Arrays for FAR2
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat FAR2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FAR2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Far21 , 5 fatty acyl CoA reductase 21, 5 84.01(n)1
    87.7(a)1
      6 (78.49 cM)5
    3304501  NM_178797.31  NP_848912.11 
     1480472595 
    chicken
    (Gallus gallus)
    Aves FAR21 fatty acyl CoA reductase 2 67.96(n)
    63.62(a)
      419043  XM_004938067.1  XP_004938124.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    62(a)
    52(a)
    many → 1
    many → 1
    5(82207004-82253127)
    5(82285622-82383112)
    zebrafish
    (Danio rerio)
    Actinopterygii FAR26
    fatty acyl CoA reductase 2
    61(a)
    1 ↔ 1
    4(1849440-1897600) ENSDARG00000009262
    fruit fly
    (Drosophila melanogaster)
    Insecta CG50651 CG5065 48.37(n)
    39.59(a)
      36860  NM_001169697.3  NP_001163168.1 
    worm
    (Caenorhabditis elegans)
    Secernentea fard-11 fard-1 48.99(n)
    37.17(a)
      180582  NM_076104.4  NP_508505.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MS21 MS2 45.34(n)
    29.82(a)
      820372  NM_112032.2  NP_187805.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g01676001 Os03g0167600 44.59(n)
    31.31(a)
      4331746  NM_001055618.1  NP_001049083.1 


    ENSEMBL Gene Tree for FAR2 (if available)
    TreeFam Gene Tree for FAR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAR2 gene
    FAR12  
    1 SIMAP similar gene for FAR2 using alignment to 6 protein entries:     FACR2_HUMAN (see all proteins):
    FAR1

    Find genes that share paralogs with FAR2           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for FAR2 (see all 12)
    PGOHUM00000247722 PGOHUM00000247724 PGOHUM00000248002 PGOHUM00000248003 PGOHUM00000246189


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAR2 (see all 3027)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1403306001,2
    --29299936(+) AACTGC/TGTTCT 1 -- us2k10--------
    rs1817970991,2
    C--29299937(+) ACTGCA/GTTCTT 1 -- us2k10--------
    rs79761841,2
    C,F--29299983(+) actccC/Tagtac 1 -- us2k12Minor allele frequency- T:0.28NA EA 240
    rs1496645421,2
    --29300030(+) CAAATG/TTAATT 1 -- us2k10--------
    rs1871852771,2
    --29300055(+) GAGGCA/CATTAA 1 -- us2k10--------
    rs769525961,2
    C,F--29300126(+) TGAACA/GTAGGG 1 -- us2k12Minor allele frequency- G:0.19CSA WA 120
    rs1902223631,2
    --29300154(+) TTATAA/GGAGAC 1 -- us2k10--------
    rs1456743851,2
    --29300214(+) CATCAC/TGGAAA 1 -- us2k10--------
    rs1488908571,2
    --29300501(+) CAACTC/TGGTAA 1 -- us2k10--------
    rs1426229831,2
    --29300705(+) TTTCTA/GTACGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FAR2 (29302036 - 29493913 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FAR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33218CNV Gain17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAR2
    DNA2.0 Custom Variant and Variant Library Synthesis for FAR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608477    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for FAR2:
    Extrahepatic bile duct carcinoma

    Find genes that share disorders with FAR2           About GenesLikeMe

    Genatlas disease: FAR2
    familial amyloidosis,renal,Ostertag type (lysozyme deposit)

    Genetic Association Database (GAD): FAR2
    Human Genome Epidemiology (HuGE) Navigator: FAR2 (1 document)

    Export disorders for FAR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAR2 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with FAR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian wax biosynthesis: I. Identification of two fatty acyl- coenzyme A reductases with different substrate specificities and tissue distributions. (PubMed id 15220348)1, 2, 3 Cheng J.B. and Russell D.W. (J. Biol. Chem. 2004)
    2. New gene functions in megakaryopoiesis and platelet formation. (PubMed id 22139419)1, 4 Gieger C....Soranzo N. (Nature 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (Chem. Biol. Interact. 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family. (PubMed id 15220349)1, 3 Cheng J.B. and Russell D.W. (J. Biol. Chem. 2004)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    9. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 55711 HGNC: 25531 AceView: MLSTD1 Ensembl:ENSG00000064763 euGenes: HUgn55711
    ECgene: FAR2 Kegg: 55711 H-InvDB: FAR2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FAR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FAR2 gene:
    Search GeneIP for patents involving FAR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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