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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAR2 Gene

protein-coding   GIFtS: 57
GCID: GC12P029302

Fatty Acyl CoA Reductase 2

(Previous name: male sterility domain containing 1)
(Previous symbol: MLSTD1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fatty Acyl CoA Reductase 21 2     Member 21
MLSTD11 2 3     Short Chain Dehydrogenase/Reductase Family 10E1
Male Sterility Domain-Containing Protein 12 3     SDR10E22
EC 1.2.1.n23 8     Fatty Acyl-CoA Reductase 22
Male Sterility Domain Containing 11     Short Chain Dehydrogenase/Reductase Family 10E, Member 22

External Ids:    HGNC: 255311   Entrez Gene: 557112   Ensembl: ENSG000000647637   UniProtKB: Q96K123   

Export aliases for FAR2 gene to outside databases

Previous GC identifers: GC12P029268 GC12P029376 GC12P029145


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FAR2 Gene:
This gene belongs to the short chain dehydrogenase/reductase superfamily. It encodes a reductase enzyme involved
in the first step of wax biosynthesis wherein fatty acids are converted to fatty alcohols. The encoded
peroxisomal protein utilizes saturated fatty acids of 16 or 18 carbons as preferred substrates. Alternatively
spliced transcript variants have been observed for this gene. Related pseudogenes have been identified on
chromosomes 2, 14 and 22. (provided by RefSeq, Nov 2012)

GeneCards Summary for FAR2 Gene: 
FAR2 (fatty acyl CoA reductase 2) is a protein-coding gene. Diseases associated with FAR2 include amyloidosis, renal, and intestinal volvulus, and among its related super-pathways are Metabolic pathways and Beta-oxidation of pristanoyl-CoA. GO annotations related to this gene include nucleotide binding and long-chain-fatty-acyl-CoA reductase activity. An important paralog of this gene is FAR1.

UniProtKB/Swiss-Prot: FACR2_HUMAN, Q96K12
Function: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. The preferred substrates are C16, C18,
C18:1 and C18:2 but low activity can be observed with C10-C14 substrates




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAR2 gene promoter:
         Nkx3-1 v4   NF-1   Pax-5   Pbx1a   Nkx3-1 v1   POU6F1 (c2)   Evi-1   MZF-1   Nkx3-1 v2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FAR2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FAR2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p11.22   Ensembl cytogenetic band:  12p11.22   HGNC cytogenetic band: 12p11.23

FAR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAR2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P029302:  view genomic region     (about GC identifiers)

Start:
29,302,036 bp from pter      End:
29,493,913 bp from pter
Size:
191,878 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FACR2_HUMAN, Q96K12 (See protein sequence)
Recommended Name: Fatty acyl-CoA reductase 2  
Size: 515 amino acids; 59438 Da
Subcellular location: Peroxisome membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum
membrane; Multi-pass membrane protein (Potential). Note=Peroxisome in cells expressing low levels of the protein.
Peroxisome and endoplasmic reticulum in cells expressing high levels of the protein
Secondary accessions: Q9H0D5 Q9NVW8

Explore the universe of human proteins at neXtProt for FAR2: NX_Q96K12

Explore proteomics data for FAR2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96K12

  • 4 DME Specific Peptides for FAR2 (Q96K12)
     FNFDVRQL  SYFRASST  IARSQMARN  TGATGFLGKVL 

    FAR2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAR2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001258712.1  NP_001258713.1  NP_060569.3  

    ENSEMBL proteins: 
     ENSP00000450117   ENSP00000443291   ENSP00000182377   ENSP00000449349   ENSP00000449436  
     ENSP00000449187   ENSP00000447467  
    Reactome Protein details: Q96K12
    Human Recombinant Protein Products for FAR2: 
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    Cloud-Clone Corp. Proteins for FAR2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005777peroxisome ISS--
    GO:0005778peroxisomal membrane IEA--
    GO:0005782peroxisomal matrix TAS--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--

    FAR2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SDRA: Short chain dehydrogenase/reductase superfamily / Atypical members

    3 InterPro protein domains:
     IPR026055 FAR
     IPR016040 NAD(P)-bd_dom
     IPR013120 Male_sterile_NAD-bd

    Graphical View of Domain Structure for InterPro Entry Q96K12

    ProtoNet protein and cluster: Q96K12

    1 Blocks protein domain: IPB013120 Male sterility C-terminal

    UniProtKB/Swiss-Prot: FACR2_HUMAN, Q96K12
    Similarity: Belongs to the fatty acyl-CoA reductase family


    FAR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FACR2_HUMAN, Q96K12
    Function: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. The preferred substrates are C16, C18,
    C18:1 and C18:2 but low activity can be observed with C10-C14 substrates
    Catalytic activity: Hexadecanal + CoA + NADP(+) = hexadecanoyl-CoA + NADPH

         Enzyme Number (IUBMB): EC 1.2.1.n21 2

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:00038543-beta-hydroxy-delta5-steroid dehydrogenase activity ----
    GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ----
    GO:0016620oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor ----
    GO:0050062long-chain-fatty-acyl-CoA reductase activity IEA--
         
    FAR2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Far2 (no phenotypes)

    FAR2 for phenotypes           About GeneDecksing

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidFAR2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FAR2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    2Peroxisomal lipid metabolism
    Peroxisomal lipid metabolism0.38
    3Plasmalogen biosynthesis
    Plasmalogen biosynthesis
    4Peroxisome
    Peroxisome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4        Reactome Pathways for FAR2
        Plasmalogen biosynthesis
    Metabolism
    Peroxisomal lipid metabolism
    Metabolism of lipids and lipoproteins


    1         Kegg Pathway  (Kegg details for FAR2):
        Peroxisome


    FAR2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAR2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for FAR2 (ENSP000001823774) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGPSENSP000002641674STRING: ENSP00000264167
    GNPATENSP000003556074STRING: ENSP00000355607
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006694steroid biosynthetic process ----
    GO:0008611ether lipid biosynthetic process TAS--
    GO:0009058biosynthetic process ----
    GO:0035336long-chain fatty-acyl-CoA metabolic process IDA15220348
    GO:0044237cellular metabolic process ----

    FAR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAR2 (FACR2)

    10/48 HMDB Compounds for FAR2 (see all 48)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexadecanol1-Cetanol (see all 82)36653-82-4--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    1-Undecanol1-Hendecanol (see all 25)112-42-5--

    Search CenterWatch for drugs/clinical trials and news about FAR2 / FACR2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAR2 gene (3 alternative transcripts): 
    NM_001271783.1  NM_001271784.1  NM_018099.4  

    Unigene Cluster for FAR2:

    Fatty acyl CoA reductase 2
    Hs.728955  [show with all ESTs]
    Unigene Representative Sequence: NM_001271783
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000551451 ENST00000536681(uc001ris.4) ENST00000549080 ENST00000547411
    ENST00000550541 ENST00000182377(uc001rit.3 uc009zjm.3) ENST00000547116
    ENST00000552137 ENST00000551193 ENST00000547759
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    hsa-miR-3200-5p hsa-miR-202
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    Additional mRNA sequence: 

    AK001324.1 AK001927.1 AK027756.1 AK129857.1 AK314670.1 AL136843.1 BC022267.1 BX537693.1 

    11 DOTS entries:

    DT.100744748  DT.208073  DT.121128420  DT.40111229  DT.101981442  DT.40111228  DT.100730511  DT.121128390 
    DT.415878  DT.95258807  DT.99985406 

    24/87 AceView cDNA sequences (see all 87):

    BC022267 AI057451 N67205 AA996057 AL136843 BG741742 BC018460 BG697652 
    AK027756 BM929835 AK129857 CK299276 AA489804 CR607516 NM_018099 BQ186333 
    CB219111 BG719367 BG698240 BI457875 AI361463 AI279458 CB998049 BG497796 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FAR2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                                                                                                                        
    SP2:                                                  -                                                                     
    SP3:                          -     -     -     -                                                                           
    SP4:                          -     -     -     -     -                                                                     
    SP5:                          -                                                                                             


    ECgene alternative splicing isoforms for FAR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAR2 expression in normal human tissues (normalized intensities)      FAR2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAAAAATAT
    FAR2 Expression
    About this image


    FAR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Blood Brain Barrier (Nervous System)
             Endothelial Cells Blood Brain Barrier
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Nose (Sensory Organs)
             sensory organ/nose/naris   
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)
             Endothelial Cells Blood Brain Barrier

    See FAR2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAR2

    SOURCE GeneReport for Unigene cluster: Hs.728955
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FAR2 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Far21 , 5 fatty acyl CoA reductase 21, 5 84.01(n)1
    87.7(a)1
      6 (78.49 cM)5
    3304501  NM_178797.31  NP_848912.11 
     1480472595 
    chicken
    (Gallus gallus)
    Aves FAR21 fatty acyl CoA reductase 2 67.9(n)
    63.62(a)
      419043  XM_417235.3  XP_417235.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    62(a)
    51(a)
    many → 1
    many → 1
    5(82207004-82253127)
    5(82285622-82383112)
    zebrafish
    (Danio rerio)
    Actinopterygii FAR26
    fatty acyl CoA reductase 2
    60(a)
    1 ↔ 1
    4(1849440-1897600)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG50651 CG5065 48.3(n)
    39.59(a)
      36860  NM_001169697.2  NP_001163168.1 
    worm
    (Caenorhabditis elegans)
    Secernentea fard-11 Protein FARD-1 49.08(n)
    37.58(a)
      180582  NM_076104.3  NP_508505.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons FAR71 putative fatty acyl-CoA reductase 7 47.51(n)
    36.22(a)
      832303  NM_122147.1  NP_197634.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g03544001 hypothetical protein 48.95(n)
    35.14(a)
      4335561  NM_001059075.1  NP_001052540.1 


    ENSEMBL Gene Tree for FAR2 (if available)
    TreeFam Gene Tree for FAR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAR2 gene
    FAR12  
    1 SIMAP similar gene for FAR2 using alignment to 6 protein entries:     FACR2_HUMAN (see all proteins):
    FAR1

    FAR2 for paralogs           About GeneDecksing


    5/12 Pseudogenes.org Pseudogenes for FAR2 (see all 12)
    PGOHUM00000247722 PGOHUM00000247724 PGOHUM00000248002 PGOHUM00000248003 PGOHUM00000246189


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3027 SNPs in FAR2 are shown (see all 3027)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0538024
    ----see VAR_0538022 I T mis40--------
    VAR_0538014
    ----see VAR_0538012 F S mis40--------
    rs1403306001,2
    --29299936(+) AACTGC/TGTTCT 1 -- us2k10--------
    rs1817970991,2
    C--29299937(+) ACTGCA/GTTCTT 1 -- us2k10--------
    rs79761841,2
    C,F--29299983(+) actccC/Tagtac 1 -- us2k12Minor allele frequency- T:0.28NA EA 240
    rs1496645421,2
    --29300030(+) CAAATG/TTAATT 1 -- us2k10--------
    rs1871852771,2
    --29300055(+) GAGGCA/CATTAA 1 -- us2k10--------
    rs769525961,2
    C,F--29300126(+) TGAACA/GTAGGG 1 -- us2k12Minor allele frequency- G:0.19CSA WA 120
    rs1902223631,2
    --29300154(+) TTATAA/GGAGAC 1 -- us2k10--------
    rs1456743851,2
    --29300214(+) CATCAC/TGGAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FAR2 (29302036 - 29493913 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FAR2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv33218CNV Gain17666407

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    5 diseases for FAR2:    About MalaCards
    amyloidosis, renal    intestinal volvulus    bile duct carcinoma    amyloidosis
    alcoholism

    1 disease from the University of Copenhagen DISEASES database for FAR2:
    Extrahepatic bile duct carcinoma

    FAR2 for disorders           About GeneDecksing

    Genatlas disease: FAR2
    familial amyloidosis,renal,Ostertag type (lysozyme deposit)

    Genetic Association Database (GAD): FAR2
    Human Genome Epidemiology (HuGE) Navigator: FAR2 (1 document)

    Export disorders for FAR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAR2 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with FAR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian wax biosynthesis: I. Identification of two fatty acyl- coenzyme A reductases with different substrate specificities and tissue distributions. (PubMed id 15220348)1, 2, 3 Cheng J.B. and Russell D.W. (2004)
    2. New gene functions in megakaryopoiesis and platelet fo rmation. (PubMed id 22139419)1, 4 Gieger C....Soranzo N. (2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family. (PubMed id 15220349)1, 3 Cheng J.B. and Russell D.W. (2004)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    9. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55711 HGNC: 25531 AceView: MLSTD1 Ensembl:ENSG00000064763 euGenes: HUgn55711
    ECgene: FAR2 Kegg: 55711 H-InvDB: FAR2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAR2 gene:
    Search GeneIP for patents involving FAR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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