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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAR1 Gene

protein-coding   GIFtS: 58
GCID: GC11P013692

Fatty Acyl CoA Reductase 1

(Previous name: male sterility domain containing 2)
(Previous symbol: MLSTD2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fatty Acyl CoA Reductase 11 2     Short Chain Dehydrogenase/Reductase Family 10E1
MLSTD21 2 3     SDR10E12
Male Sterility Domain Containing 21 2     Fatty Acyl-CoA Reductase 12
Male Sterility Domain-Containing Protein 22 3     Putative Fatty Acyl Reductase2
EC 1.2.1.n23 8     Short Chain Dehydrogenase/Reductase Family 10E, Member 12
Member 11     

External Ids:    HGNC: 262221   Entrez Gene: 841882   Ensembl: ENSG000001976017   UniProtKB: Q8WVX93   

Export aliases for FAR1 gene to outside databases

Previous GC identifers: GC11P013647 GC11P013370


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAR1 Gene: 
FAR1 (fatty acyl CoA reductase 1) is a protein-coding gene. Diseases associated with FAR1 include amyloidosis, renal, and intestinal volvulus, and among its related super-pathways are Metabolic pathways and Beta-oxidation of pristanoyl-CoA. GO annotations related to this gene include nucleotide binding and long-chain-fatty-acyl-CoA reductase activity. An important paralog of this gene is FAR2.

UniProtKB/Swiss-Prot: FACR1_HUMAN, Q8WVX9
Function: Catalyzes the reduction of saturated fatty acyl-CoA with chain length C16 or C18 to fatty alcohols

Gene Wiki entry for FAR1 (MLSTD2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAR1 gene promoter:
         STAT5B   Pax-5   AML1a   GCNF   CBF-C   AREB6   CBF-B   GCNF-1   TGIF   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FAR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.2   Ensembl cytogenetic band:  11p15.2   HGNC cytogenetic band: 11p15.2

FAR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAR1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P013692:  view genomic region     (about GC identifiers)

Start:
13,690,206 bp from pter      End:
13,753,893 bp from pter
Size:
63,688 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FACR1_HUMAN, Q8WVX9 (See protein sequence)
Recommended Name: Fatty acyl-CoA reductase 1  
Size: 515 amino acids; 59357 Da
Subcellular location: Peroxisome membrane; Single-pass membrane protein (Potential)
Secondary accessions: D3DQW8 Q5CZA3

Explore the universe of human proteins at neXtProt for FAR1: NX_Q8WVX9

Explore proteomics data for FAR1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WVX9

  • 4/15 DME Specific Peptides for FAR1 (Q8WVX9) (see all 15)
     AIVRPSIV  PEDKKTFN  SYFRASST  KHIDEVVYP 

    FAR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAR1 Protein Expression
    REFSEQ proteins: NP_115604.1  
    ENSEMBL proteins: 
     ENSP00000346874   ENSP00000437111   ENSP00000434624  
    Reactome Protein details: Q8WVX9
    Human Recombinant Protein Products for FAR1: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for FAR1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005777peroxisome IDA--
    GO:0005778peroxisomal membrane IDA--
    GO:0005782peroxisomal matrix TAS--
    GO:0016021integral to membrane IEA--

    FAR1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for FAR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SDRA: Short chain dehydrogenase/reductase superfamily / Atypical members

    3 InterPro protein domains:
     IPR026055 FAR
     IPR016040 NAD(P)-bd_dom
     IPR013120 Male_sterile_NAD-bd

    Graphical View of Domain Structure for InterPro Entry Q8WVX9

    ProtoNet protein and cluster: Q8WVX9

    1 Blocks protein domain: IPB013120 Male sterility C-terminal

    UniProtKB/Swiss-Prot: FACR1_HUMAN, Q8WVX9
    Similarity: Belongs to the fatty acyl-CoA reductase family


    FAR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FACR1_HUMAN, Q8WVX9
    Function: Catalyzes the reduction of saturated fatty acyl-CoA with chain length C16 or C18 to fatty alcohols
    Catalytic activity: Hexadecanal + CoA + NADP(+) = hexadecanoyl-CoA + NADPH

         Enzyme Number (IUBMB): EC 1.2.1.n21 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0050062long-chain-fatty-acyl-CoA reductase activity IEA--
    GO:0050662coenzyme binding ----
    GO:0080019fatty-acyl-CoA reductase (alcohol-forming) activity IDA15220348
         
    FAR1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Far1 (no phenotypes)

    FAR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Far1tm1Lex for FAR1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FAR1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FAR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAR1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAR1 

    miRNA
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    miRTarBase miRNAs that target FAR1:
    hsa-mir-155 (MIRT005244)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FAR1
    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate FAR1 (see all 47):
    hsa-miR-124* hsa-miR-579 hsa-miR-576-3p hsa-miR-4328 hsa-miR-4272 hsa-miR-25 hsa-miR-124 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidFAR1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAR1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FAR1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    2Peroxisomal lipid metabolism
    Peroxisomal lipid metabolism0.38
    3Plasmalogen biosynthesis
    Plasmalogen biosynthesis
    4Peroxisome
    Peroxisome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4        Reactome Pathways for FAR1
        Plasmalogen biosynthesis
    Metabolism
    Peroxisomal lipid metabolism
    Metabolism of lipids and lipoproteins


    1         Kegg Pathway  (Kegg details for FAR1):
        Peroxisome


    FAR1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/17 Interacting proteins for FAR1 (Q8WVX91, 3 ENSP000003468744) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C20orf24Q9BUV81, 3, ENSP000003412134EBI-1045879,EBI-1050079 I2D: score=2 STRING: ENSP00000341213
    SMYD3Q9H7B43, ENSP000003736374I2D: score=1 STRING: ENSP00000373637
    PEX19P408553I2D: score=2 
    SLC2A4P146723I2D: score=2 
    SMARCB1Q128243I2D: score=2 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008611ether lipid biosynthetic process TAS--
    GO:0009058biosynthetic process ----
    GO:0010025wax biosynthetic process IEA--
    GO:0035336long-chain fatty-acyl-CoA metabolic process IDA15220348
    GO:0044237cellular metabolic process ----

    FAR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAR1 (FACR1)

    10/41 HMDB Compounds for FAR1 (see all 41)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    1-Hexadecanol1-Cetanol (see all 82)36653-82-4--
    1-Undecanol1-Hendecanol (see all 25)112-42-5--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--

    Search CenterWatch for drugs/clinical trials and news about FAR1 / FACR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAR1 gene: 
    NM_032228.5  

    Unigene Cluster for FAR1:

    Fatty acyl CoA reductase 1
    Hs.501991  [show with all ESTs]
    Unigene Representative Sequence: BX648892
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354817(uc001mld.3) ENST00000532701(uc009ygp.3) ENST00000532769
    ENST00000524933 ENST00000527202 ENST00000532502
    miRNA
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    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate FAR1 (see all 47):
    hsa-miR-124* hsa-miR-579 hsa-miR-576-3p hsa-miR-4328 hsa-miR-4272 hsa-miR-25 hsa-miR-124 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidFAR1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF086349.1 AK024967.1 AK026381.1 AK090880.1 AK315527.1 AL713674.1 AY358784.1 AY423606.1 
    AY600449.1 BC017377.2 BX648892.1 CR936619.1 

    9 DOTS entries:

    DT.100783042  DT.447695  DT.434105  DT.97825563  DT.40200297  DT.95373486  DT.100647445  DT.102826825 
    DT.120706530 

    24/283 AceView cDNA sequences (see all 283):

    BM455230 BX506564 AI378343 BQ001747 BM849241 CB133786 BQ448039 BU173136 
    BF222056 AA281165 BP360589 AA732368 AK024967 BE464102 BM782950 AI452721 
    AA026320 BC017377 BM772171 AI215907 BG107731 CB113184 AW474137 AF086349 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for FAR1 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^ 14 ^ 15a ·
    SP1:        -     -     -                                                                       -                             -           -           -     -   
    SP2:        -     -     -                                                                       -                             -                                 
    SP3:                                                                                            -                                         -                     
    SP4:                                                                                                                                      -           -     -   
    SP5:        -     -     -                             -     -     -     -     -     -           -                                                               

    ExUns: 15b ^ 16 ^ 17a · 17b · 17c
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for FAR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAACTAGA
    FAR1 Expression
    About this image


    See FAR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAR1

    SOURCE GeneReport for Unigene cluster: Hs.501991
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FAR1 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Far11 , 5 fatty acyl CoA reductase 11, 5 92.82(n)1
    98.06(a)1
      7 (59.21 cM)5
    674201  NM_026143.21  NP_080419.21 
     1135138345 
    chicken
    (Gallus gallus)
    Aves FAR11 fatty acyl CoA reductase 1 82.65(n)
    89.71(a)
      423028  NM_001031179.1  NP_001026350.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    86(a)
    80(a)
    1 ↔ many
    1 ↔ many
    AAWZ02039333(1411-8554)
    GL343237.1(1595395-1627718)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC045017.12   -- 74.34(n)    BC045017.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.207972 Danio rerio mRNA similar to RIKEN cDNA 3732409C05 gene more 74.48(n)    BC044166.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG14431 CG1443 45.48(n)
    35.36(a)
      43420  NM_143395.1  NP_651652.2 
    worm
    (Caenorhabditis elegans)
    Secernentea fard-16
    Protein FARD-1
    37(a)
    1 → many
    X(2933361-2937742)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MS21 fatty acyl-CoA reductase 2 44.39(n)
    29.26(a)
      820372  NM_112032.2  NP_187805.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g01676001 hypothetical protein 42.75(n)
    29.36(a)
      4331746  NM_001055618.1  NP_001049083.1 


    ENSEMBL Gene Tree for FAR1 (if available)
    TreeFam Gene Tree for FAR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAR1 gene
    FAR22  
    1 SIMAP similar gene for FAR1 using alignment to 3 protein entries:     FACR1_HUMAN (see all proteins):
    FAR2

    FAR1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FAR1
    PGOHUM00000248661


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1217 SNPs in FAR1 are shown (see all 1217)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs361225771,2
    C--13426410(+) AAAAA-/A/AA  
            
    GTAAT
    1 -- int11NA 2
    rs1490734671,2
    --13688328(+) AAAAGC/TTTATG 1 -- us2k10--------
    rs1906547721,2
    --13688371(+) TAGTGA/GTATTA 1 -- us2k10--------
    rs1168540791,2
    C--13688373(+) GTGATA/CTTACC 1 -- us2k11Minor allele frequency- C:0.01EA 120
    rs1422328551,2
    --13688420(+) TTAGCC/TACACA 1 -- us2k10--------
    rs1512132141,2
    --13688532(+) TTAAAC/TCCTAT 1 -- us2k10--------
    rs1814727701,2
    --13688574(+) TATGCA/CTAGTG 1 -- us2k10--------
    rs79517251,2
    C,F--13688621(+) TTTAAA/GCAACT 1 -- us2k11Minor allele frequency- G:0.06WA 118
    rs1860595461,2
    --13688678(+) GCTTGA/TGTTCT 1 -- us2k10--------
    rs79371641,2
    C,F--13688745(+) ACCCAC/GTTCTA 1 -- us2k11Minor allele frequency- G:0.06WA 118

    HapMap Linkage Disequilibrium report for FAR1 (13690206 - 13753893 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FAR1: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FAR1
    DNA2.0 Custom Variant and Variant Library Synthesis for FAR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    5 diseases for FAR1:    About MalaCards
    amyloidosis, renal    intestinal volvulus    filariasis    amyloidosis
    alcoholism


    FAR1 for disorders           About GeneDecksing

    Genatlas disease: FAR1
    familial amyloidosis,renal,Ostertag type (FGA deposit)


    Export disorders for FAR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAR1 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with FAR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian wax biosynthesis: I. Identification of two fatty acyl- coenzyme A reductases with different substrate specificities and tissue distributions. (PubMed id 15220348)1, 2, 3 Cheng J.B. and Russell D.W. (2004)
    2. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family. (PubMed id 15220349)1, 3 Cheng J.B. and Russell D.W. (2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. Posttranslational regulation of fatty acyl-CoA reduct ase 1, Far1, controls ether glycerophospholipid synthesis. (PubMed id 20071337)1, 9 Honsho M....Fujiki Y. (2010)
    7. Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. (PubMed id 23464991)1 Scifo E....Lalowski M. (2013)
    8. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    9. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (2013)
    10. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84188 HGNC: 26222 AceView: MLSTD2 Ensembl:ENSG00000197601 euGenes: HUgn84188
    ECgene: FAR1 Kegg: 84188 H-InvDB: FAR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAR1 gene:
    Search GeneIP for patents involving FAR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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