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FAP Gene

protein-coding   GIFtS: 61
GCID: GC02M163027

Fibroblast Activation Protein, Alpha

  See FAP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibroblast Activation Protein, Alpha1 2     FAPA2 5
seprase1 2     DPPIV2
Integral Membrane Serine Protease2 3     EC 3.4.21.-3
170 KDa Melanoma Membrane-Bound Gelatinase2 3     Fibroblast Activation Protein Alpha3

External Ids:    HGNC: 35901   Entrez Gene: 21912   Ensembl: ENSG000000780987   OMIM: 6004035   UniProtKB: Q128843   

Export aliases for FAP gene to outside databases

Previous GC identifers: GC02M161080 GC02M161555 GC02M162991 GC02M163229 GC02M162852 GC02M162735 GC02M154909


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FAP Gene:
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease
family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of
healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in
the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and
epithelial carcinogenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for FAP Gene:
FAP (fibroblast activation protein, alpha) is a protein-coding gene. Diseases associated with FAP include infiltrative basal cell carcinoma, and pharyngitis. GO annotations related to this gene include protein dimerization activity and protein homodimerization activity. An important paralog of this gene is DPP8.

UniProtKB/Swiss-Prot: SEPR_HUMAN, Q12884
Function: In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM),
the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during
development and wound healing, and may contribute to invasiveness in malignant cancers

Gene Wiki entry for FAP (Fibroblast activation protein, alpha) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAP gene promoter:
         AREB6   PPAR-gamma1   PPAR-gamma2   ITF-2   Tal-1beta   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAP promoter sequence
   Search Chromatin IP Primers for FAP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q23   Ensembl cytogenetic band:  2q24.2   HGNC cytogenetic band: 2q23

FAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAP gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M163027:  view genomic region     (about GC identifiers)

Start:
163,027,194 bp from pter      End:
163,101,661 bp from pter
Size:
74,468 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SEPR_HUMAN, Q12884 (See protein sequence)
Recommended Name: Seprase  
Size: 760 amino acids; 87713 Da
Subunit: Homodimer, or heterodimer with DPP4. The monomer is inactive
1 PDB 3D structure from and Proteopedia for FAP:
1Z68 (3D)    
Secondary accessions: O00199 Q53TP5 Q86Z29 Q99998 Q9UID4
Alternative splicing: 2 isoforms:  Q12884-1   Q12884-2   (Major isoform)

Explore the universe of human proteins at neXtProt for FAP: NX_Q12884

Explore proteomics data for FAP at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • The N-terminus may be blocked1
  • Glycosylation2 at Asn49, Asn92, Asn99, Asn227, Asn314, Asn679
  • Modification sites at PhosphoSitePlus

  • See FAP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004451.2  
    ENSEMBL proteins: 
     ENSP00000441940   ENSP00000417028   ENSP00000188790   ENSP00000411391   ENSP00000400137  
     ENSP00000407404  

    FAP Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for FAP
    Sino Biological Cell Lysate for FAP
    ProSpec Recombinant Protein for FAP
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    antibodies-online proteins for FAP (46 products) 

     
    antibodies-online peptides for FAP

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    FAP Assay Products:

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    antibodies-online kits for FAP (48 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001375 Peptidase_S9
     IPR002471 Pept_S9_AS
     IPR002469 Peptidase_S9B

    Graphical View of Domain Structure for InterPro Entry Q12884

    ProtoNet protein and cluster: Q12884

    2 Blocks protein domains:
    IPB002469 Dipeptidylpeptidase IV (CD26)
    IPB002471 Prolyl endopeptidase


    UniProtKB/Swiss-Prot: SEPR_HUMAN, Q12884
    Similarity: Belongs to the peptidase S9B family


    Find genes that share domains with FAP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEPR_HUMAN, Q12884
    Function: In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM),
    the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during
    development and wound healing, and may contribute to invasiveness in malignant cancers
    Catalytic activity: Degrades gelatin and heat-denatured type I and type IV collagen, but not native type I or type
    IV collagen. Does not cleave laminin, fibronectin, fibrin or casein
    Induction: In fibroblasts at times and sites of tissue remodeling during development, tissue repair, and
    carcinogenesis

         Genatlas biochemistry entry for FAP:
    fibroblast activation protein alpha (95kDa),expressed in epithelial cancer stroma,same gene as seprase

         Enzyme Number (IUBMB): EC 3.4.21.-1

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI17317851
    GO:0004175endopeptidase activity IDA17317851
    GO:0004222metalloendopeptidase activity TAS9065413
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0005515protein binding IPI16651416
         
    Find genes that share ontologies with FAP           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Fap):
     normal 

    Find genes that share phenotypes with FAP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Faptm1Schn for FAP

       genOway: Develop your customized and physiologically relevant rodent model for FAP

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    SwitchGear 3'UTR luciferase reporter plasmidFAP 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SEPR_HUMAN, Q12884: Cell membrane; Single-pass type II membrane protein. Cell projection, lamellipodium
    membrane; Single-pass type II membrane protein. Cell projection, invadopodium membrane; Single-pass type II
    membrane protein. Note=Found in cell surface lamellipodia, invadopodia and on shed vesicles. Colocalized with
    DPP4 in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized
    with DPP4 on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal
    carcinoma
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular4
    golgi apparatus2
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA17317851
    GO:0016020membrane ----
    GO:0016021integral component of membrane NAS9065413
    GO:0030027lamellipodium IDA16651416
    GO:0030054cell junction IEA--

    Find genes that share ontologies with FAP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including FAP: 
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for FAP (Q128841, 2, 3 ENSP000001887904) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GHRHP012862, 3, ENSP000002375274MINT-8090620 I2D: score=1 STRING: ENSP00000237527
    GIPP096812, 3, ENSP000003500054MINT-8090786 I2D: score=1 STRING: ENSP00000350005
    NPYP013032, 3, ENSP000002421524MINT-8090736 I2D: score=1 STRING: ENSP00000242152
    PYYP100822, 3, ENSP000003531984MINT-8090673 I2D: score=1 STRING: ENSP00000353198
    ADCYAP1P185092, 3MINT-8094219 I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0010716negative regulation of extracellular matrix disassembly IDA16651416
    GO:0043542endothelial cell migration IDA16651416
    GO:0051917regulation of fibrinolysis IC17317851

    Find genes that share ontologies with FAP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAP (SEPR)

    4 Novoseek inferred chemical compound relationships for FAP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dpps 74.7 2 17328877 (1)
    serine 71.4 75 9065413 (4), 9247085 (3), 10593948 (2), 15713998 (2) (see all 40)
    proline 25.3 5 14687920 (1), 12941425 (1)
    matrigel 17.4 4 16175601 (1), 11166278 (1)



    Find genes that share compounds with FAP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAP gene: 
    NM_004460.2  

    Unigene Cluster for FAP:

    Fibroblast activation protein, alpha
    Hs.654370  [show with all ESTs]
    Unigene Representative Sequence: U09278
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000462608 ENST00000422436(uc010fpc.3) ENST00000480044 ENST00000188790(uc002ucd.3 uc010zct.2)
    ENST00000443424 ENST00000461506 ENST00000497414 ENST00000465424 ENST00000465088
    ENST00000480838(uc010fpe.1) ENST00000447386 ENST00000450031 ENST00000493182

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    hsa-miR-30c hsa-miR-30a hsa-miR-30b hsa-miR-30d hsa-miR-552 hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidFAP 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat FAP
      QuantiFast Probe-based Assays in human, mouse, rat FAP

    Additional mRNA sequence: 

    AK055327.1 AK297118.1 AK309260.1 AK310293.1 AK315448.1 AL832166.1 BC026250.1 U09278.1 
    U76833.1 

    13 DOTS entries:

    DT.97812040  DT.95159665  DT.100755453  DT.121028522  DT.443803  DT.121028496  DT.100755454  DT.121028523 
    DT.40233450  DT.70102446  DT.91720537  DT.95159664  DT.40127122 

    Selected AceView cDNA sequences (see all 103):

    AA968637 BC026250 NM_004460 BX509354 BM988531 CN480703 W45237 BM449645 
    AW069387 BE925603 U76833 AA587181 AI682584 AI520664 BU952044 AI452780 
    AI925529 CR604386 AL702298 AL701981 BM905757 CA412273 BU633477 BP335737 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FAP (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^
    SP1:        -                                                                                                                 -     -     -           -     -   
    SP2:                                                                                                                                      -           -     -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                  -     -   

    ExUns: 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30
    SP1:        -                       -           -                                 
    SP2:        -                       -           -                                 
    SP3:                                                                              
    SP4:                                                                              
    SP5:        -                                                                     


    ECgene alternative splicing isoforms for FAP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTTTGCTT
    FAP Expression
    About this image


    FAP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 3 entries
             PureStem SK11, NCr-fac & Meso-prx Progenitor
     
     Fibroblasts
             Mature Cardiac Fibroblasts Myocardium
             Detroit 551
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Mature Cardiac Fibroblasts Myocardium
     
     Paraxial Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem SK11, NCr-fac & Meso-prx Progenitor
    FAP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654370

    UniProtKB/Swiss-Prot: SEPR_HUMAN, Q12884
    Tissue specificity: Fibroblast specific

        Pathway & Disease-focused RT2 Profiler PCR Array including FAP: 
              Cell Motility in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FAP gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fap1 , 5 fibroblast activation protein1, 5 89.43(n)1
    89.61(a)1
      2 (35.85 cM)5
    140891  NM_007986.31  NP_032012.11 
     625009435 
    chicken
    (Gallus gallus)
    Aves FAP1 fibroblast activation protein, alpha 75.1(n)
    73.65(a)
      424186  NM_001193639.2  NP_001180568.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAP6
    fibroblast activation protein, alpha
    66(a)
    1 ↔ 1
    GL343359.1(425361-488286)
    African clawed frog
    (Xenopus laevis)
    Amphibia fap-A2 fibroblast activation protein, alpha 76.84(n)    U41856.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fap6
    dpp46
    dipeptidyl-peptidase 4
    51(a)
    48(a)
    many ↔ many
    many ↔ many
    9(52571610-52607604) ENSDARG00000078468
    22(11738704-11758472) ENSDARG00000079420
    fruit fly
    (Drosophila melanogaster)
    Insecta CG113193
    ome1
    dipeptidyl-peptidase IV3
    omega1
    35(a)
    (best of 2)3
    46.05(n)1
    36.38(a)1
      442971  NM_001104136.21  NP_001097606.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T23F1.7b3   -- 30(a)
    (best of 3)
      V(15473968-15478599)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DAP26
    STE136
    Dipeptidyl aminopeptidase, synthesized as a glycos...
    Dipeptidyl aminopeptidase, Golgi integral membrane...
    26(a)
    21(a)
    many ↔ many
    many ↔ many
    VIII(164978-167434) YHR028C
    XV(752214-755009) YOR219C


    ENSEMBL Gene Tree for FAP (if available)
    TreeFam Gene Tree for FAP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAP gene
    DPP82  DPP102  DPP62  DPP92  DPP42  
    3 SIMAP similar genes for FAP using alignment to 6 protein entries:     SEPR_HUMAN (see all proteins):
    DPP4    DPP6    DPP10

    Find genes that share paralogs with FAP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAP (see all 1495)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1876600501,2
    --162423575(+) AATCTC/GAAAGC 1 -- ds50010--------
    rs1437671301,2
    --162423655(+) AAGGAA/GTCTGA 1 -- ds50010--------
    rs1925143071,2
    C--162423729(+) GAAATG/TTAATA 1 -- ds50010--------
    rs1174934281,2
    F--162423778(+) CAAACG/ATGATT 1 -- ds50011Minor allele frequency- A:0.01EA 120
    rs1849190521,2
    --162423791(+) CTTGCA/GTTTTC 1 -- ds50010--------
    rs75606921,2
    H--162423856(+) TGACAG/CAAATC 1 -- ds50014Minor allele frequency- C:0.00NS EA 402
    rs1379129601,2
    C--162423874(+) ACTTCC/TAGATT 1 -- ds50010--------
    rs801097301,2
    C--162423975(+) GAATAC/GAGACA 1 -- ds50010--------
    rs1424551361,2
    --162424064(+) ATGCAG/TGACTC 1 -- ut310--------
    rs1881170571,2
    --162424102(+) GAAAAC/TGTAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FAP (163027194 - 163101661 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FAP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3009CNV Insertion18451855
    nsv834440CNV Gain17160897
    nsv834439CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAP
    DNA2.0 Custom Variant and Variant Library Synthesis for FAP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600403    OMIM disorders: --

    2 diseases for FAP:    
    About MalaCards
    infiltrative basal cell carcinoma    pharyngitis

    1 disease from the University of Copenhagen DISEASES database for FAP:
    Pharyngitis

    Find genes that share disorders with FAP           About GenesLikeMe

    Selected Novoseek inferred disease relationships for FAP gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    stromal tumors 73.5 6 8201382 (2), 10593948 (1), 12542520 (1), 12183436 (1) (see all 5)
    epithelial tumor 48.7 5 18095711 (2), 10593948 (1), 8391923 (1), 7519584 (1)
    metastasis 47 28 12963128 (4), 16196122 (4), 17363526 (3), 14707457 (2) (see all 15)
    melanoma 46.7 26 12542520 (4), 9065413 (3), 7923219 (3), 9247085 (2) (see all 12)
    cancer 44.1 54 17047060 (5), 9139873 (2), 17363526 (2), 18787344 (2) (see all 29)
    carcinoma ductal 34.5 7 11241314 (3), 9758365 (2), 17047060 (1), 14524536 (1)
    tumors 32.2 59 17363526 (7), 12183436 (4), 15713998 (3), 15087384 (3) (see all 22)
    sarcoma 26.3 5 8391923 (2), 7519584 (1), 7911242 (1), 19817894 (1)
    skin tumor 25.5 3 12542520 (1), 16420310 (1)
    carcinoma 24.2 9 9065413 (1), 18787344 (1), 15713998 (1), 12183436 (1) (see all 6)

    Genetic Association Database (GAD): FAP
    Human Genome Epidemiology (HuGE) Navigator: FAP (173 documents)

    Export disorders for FAP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAP gene, integrated from 10 sources (see all 145):
    (articles sorted by number of sources associating them with FAP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of seprase: a serine integral membrane protease from human melanoma. (PubMed id 9247085)1, 2, 3, 9 Goldstein L.A.... Chen W.-T. (Biochim. Biophys. Acta 1997)
    2. Identification of the 170-kDa melanoma membrane-bound gelatinase (seprase) as a serine integral membrane protease. (PubMed id 9065413)1, 2, 9 Pineiro-Sanchez M.L....Chen W.-T. (J. Biol. Chem. 1997)
    3. Seprase, a membrane-type serine protease, has different expression patterns in intestinal- and diffuse-type gastric cancer. (PubMed id 14707457)1, 3, 9 Okada K....Mitsumata M. (Oncology 2003)
    4. Fibroblast activation protein: purification, epitope mapping and induction by growth factors. (PubMed id 7519584)1, 2, 9 Rettig W.J.... Old L.J. (Int. J. Cancer 1994)
    5. The protease complex consisting of dipeptidyl peptidase IV and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices. (PubMed id 16651416)1, 2, 9 Ghersi G.... Chen W.T. (Cancer Res. 2006)
    6. Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers. (PubMed id 7911242)1, 2, 9 Scanlan M.J.... Rettig W.J. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    7. Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alpha. (PubMed id 15809306)1, 2, 9 Aertgeerts K....Tennant M.G. (J. Biol. Chem. 2005)
    8. Identification of an alternatively spliced seprase mRNA that encodes a novel intracellular isoform. (PubMed id 10644713)1, 2, 9 Goldstein L.A. and Chen W.-T. (J. Biol. Chem. 2000)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    10. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2191 HGNC: 3590 AceView: FAP Ensembl:ENSG00000078098 euGenes: HUgn2191
    ECgene: FAP H-InvDB: FAP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FAP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FAP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FAP gene:
    Search GeneIP for patents involving FAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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