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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAP Gene

protein-coding   GIFtS: 61
GCID: GC02M163027

fibroblast activation protein, alpha
 Explore 41 diseases affiliated with
FAP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FAP    

Aliases
for FAP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Fibroblast Activation Protein, Alpha1 2     FAPA2 5
DPPIV1 2     Seprase1
Integral Membrane Serine Protease2 3     EC 3.4.21.-3
170 KDa Melanoma Membrane-Bound Gelatinase2 3     Fibroblast Activation Protein Alpha3

External Ids:    HGNC: 35901   Entrez Gene: 21912   Ensembl: ENSG000000780987   OMIM: 6004035   UniProtKB: Q128843   

Export aliases for FAP gene to outside databases

Previous GC identifers: GC02M161080 GC02M161555 GC02M162991 GC02M163229 GC02M162852 GC02M162735 GC02M154909


Summaries
for FAP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FAP:
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family.
It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing
wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of
fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial
carcinogenesis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SEPR_HUMAN, Q12884
Function: In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the
migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and
wound healing, and may contribute to invasiveness in malignant cancers

Gene Wiki entry for FAP (Fibroblast activation protein, alpha)


Genomic Views
for FAP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAP gene promoter:
         AREB6   PPAR-gamma1   PPAR-gamma2   ITF-2   Tal-1beta   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FAP promoter sequence
   Search SABiosciences Chromatin IP Primers for FAP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q23   Ensembl cytogenetic band:  2q24.2   HGNC cytogenetic band: 2q23

FAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAP gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M163027:  view genomic region     (about GC identifiers)

Start:
 163,027,194 bp from pter      End:
 163,101,661 bp from pter
Size:
 74,468 bases      Orientation:
 minus strand

Proteins
for FAP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SEPR_HUMAN, Q12884 (See protein sequence)
Recommended Name: Seprase  
Size: 760 amino acids; 87713 Da
Subunit: Homodimer, or heterodimer with DPP4. The monomer is inactive
Subcellular location: Cell membrane; Single-pass type II membrane protein. Cell projection, lamellipodium membrane;
Single-pass type II membrane protein. Cell projection, invadopodium membrane; Single-pass type II membrane protein.
Note=Found in cell surface lamellipodia, invadopodia and on shed vesicles. Colocalized with DPP4 in invadopodia and
lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with DPP4 on endothelial
cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma
1 PDB 3D structure from and Proteopedia for FAP:
1Z68 (3D)    
Secondary accessions: O00199 Q53TP5 Q86Z29 Q99998 Q9UID4
Alternative splicing: 2 isoforms:  Q12884-1   Q12884-2   (Major isoform)

Explore the universe of human proteins at neXtProt for FAP: NX_Q12884

Post-translational modifications:

  • N-glycosylated1
  • The N-terminus may be blocked1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q12884

    • FAP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004451.2  
    ENSEMBL proteins: 
     ENSP00000441940   ENSP00000417028   ENSP00000188790   ENSP00000411391   ENSP00000400137  
     ENSP00000407404  

    Human Recombinant Protein Products: 
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    Novus Biologicals FAP Proteins
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    ProSpec Recombinant Protein for FAP
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA17317851
    GO:0016020membrane ----
    GO:0016021integral to membrane NAS9065413
    GO:0030027lamellipodium IDA16651416
    GO:0030054cell junction IEA--


    FAP for ontologies           About GeneDecksing



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    Assay Products for FAP: 
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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for FAP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FAP for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001375 Peptidase_S9
     IPR002471 Pept_S9_AS
     IPR002469 Peptidase_S9B

    Graphical View of Domain Structure for InterPro Entry Q12884

    ProtoNet protein and cluster: Q12884

    2 Blocks protein families:
    IPB002469 Dipeptidylpeptidase IV (CD26)
    IPB002471 Prolyl endopeptidase


    UniProtKB/Swiss-Prot: SEPR_HUMAN, Q12884
    Similarity: Belongs to the peptidase S9B family


    Function
    for FAP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SEPR_HUMAN, Q12884
    Function: In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the
    migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and
    wound healing, and may contribute to invasiveness in malignant cancers
    Catalytic activity: Degrades gelatin and heat-denatured type I and type IV collagen, but not native type I or type IV
    collagen. Does not cleave laminin, fibronectin, fibrin or casein
    Induction: In fibroblasts at times and sites of tissue remodeling during development, tissue repair, and carcinogenesis

         Genatlas biochemistry entry for FAP:
    fibroblast activation protein alpha (95kDa),expressed in epithelial cancer stroma,same gene as seprase

    Enzyme Number (IUBMB): EC 3.4.21.-1

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate FAP:
    hsa-miR-30c hsa-miR-30a hsa-miR-30b hsa-miR-30d hsa-miR-552 hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmid: FAP 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: FAP
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI17317851
    GO:0004175endopeptidase activity IDA17317851
    GO:0004222metalloendopeptidase activity TAS9065413
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0005515protein binding IPI16651416


    FAP for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Faptm1Schn for FAP
         1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Fap):
     normal 

    FAP for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FAP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/14 Interacting proteins for FAP (Q128842, 3 ENSP000001887904) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GHRHP012862, 3, ENSP000002375274MINT-8090620 I2D: score=1 STRING: ENSP00000237527
    GIPP096812, 3, ENSP000003500054MINT-8090786 I2D: score=1 STRING: ENSP00000350005
    NPYP013032, 3, ENSP000002421524MINT-8090736 I2D: score=1 STRING: ENSP00000242152
    PYYP100822, 3, ENSP000003531984MINT-8090673 I2D: score=1 STRING: ENSP00000353198
    ADCYAP1P185092, 3MINT-8094219 I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0010716negative regulation of extracellular matrix disassembly IDA16651416
    GO:0043542endothelial cell migration IDA16651416
    GO:0051917regulation of fibrinolysis IC17317851


    FAP for ontologies           About GeneDecksing



    Drugs & Compounds
    for FAP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FAP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAP
    4 Novoseek chemical compound relationships for FAP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dpps 74.7 2 17328877 (1)
    serine 71.4 75 9065413 (4), 9247085 (3), 10593948 (2), 15713998 (2) (see all 40)
    proline 25.3 5 14687920 (1), 12941425 (1)
    matrigel 17.4 4 16175601 (1), 11166278 (1)

    Search CenterWatch for drugs/clinical trials and news about FAP / SEPR 

    Transcripts
    for FAP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FAP gene: 
    NM_004460.2  

    Unigene Cluster for FAP:

    Fibroblast activation protein, alpha
    Hs.654370  [show with all ESTs]
    Unigene Representative Sequence: U09278
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000462608 ENST00000422436(uc010fpc.3) ENST00000480044 ENST00000463399
    ENST00000188790(uc002ucd.3 uc010zct.2) ENST00000443424 ENST00000461506
    ENST00000497414 ENST00000465424 ENST00000465088 ENST00000480838(uc010fpe.1)
    ENST00000447386 ENST00000450031 ENST00000493182

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate FAP:
    hsa-miR-30c hsa-miR-30a hsa-miR-30b hsa-miR-30d hsa-miR-552 hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmid: FAP 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAP (see all 7)
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    OriGene siRNA: FAP
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAP

    Additional cDNA sequence: 

    AK055327.1 AK297118.1 AK309260.1 AK310293.1 AK315448.1 AL832166.1 BC026250.1 U09278.1 
    U76833.1 

    13 DOTS entries:

    DT.97812040  DT.95159665  DT.100755453  DT.121028522  DT.443803  DT.121028496  DT.100755454  DT.121028523 
    DT.40233450  DT.70102446  DT.91720537  DT.95159664  DT.40127122 

    24/103 AceView cDNA sequences (see all 103):

    AI520664 AI682584 AA587181 BX095108 CA412273 BU633477 CR606795 BM905757 
    CR604386 AL702298 AW069387 AI925529 W45237 BX509354 BM449645 BM988531 
    CN480703 BP335737 BU952044 AI452780 AL701981 BM906508 BF969248 NM_004460 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for FAP (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^
    SP1:        -                                                                                                                 -     -     -           -     -   
    SP2:                                                                                                                                      -           -     -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                  -     -   

    ExUns: 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30
    SP1:        -                       -           -                                 
    SP2:        -                       -           -                                 
    SP3:                                                                              
    SP4:                                                                              
    SP5:        -                                                                     


    ECgene alternative splicing isoforms for FAP

    Expression
    for FAP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CATTTTGCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FAP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartAtrioventricular NodeAtrioventricular Node CellsMyocardium
    KidneyMetanephric MesenchymeMetanephric Mesenchyme CellsKidney
    BoneMembranous Facial BonesBone
    CartilageNasal CapsuleCartilage
    Head MesenchymeHead MesenchymeHead Mesenchyme
    LimbAutopodLimb
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    Beating cell clusters (Spontaneous differen...)

    See FAP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAP

    SOURCE GeneReport for Unigene cluster: Hs.654370

    UniProtKB/Swiss-Prot: SEPR_HUMAN, Q12884
    Tissue specificity: Fibroblast specific

        SABiosciences Expression via Pathway-Focused PCR Array including FAP: 
              Cell Motility in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for FAP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FAP gene from 7/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FAP1 fibroblast activation protein, alpha 75.1(n)
    73.65(a)    		   424186  NM_001193639.1  NP_001180568.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FAP6
    		 --
    		 66(a)
    		 1 ↔ 1
    		 GL343359.1(425361-488096)
    African clawed frog
    (Xenopus laevis)    		 Amphibia fap-A2 fibroblast activation protein, alpha 76.84(n)    U41856.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii fap6
    dpp46
    		 dipeptidyl-peptidase 4
    		 51(a)
    48(a)
    		 many ↔ many
    many ↔ many
    		 9(52571610-52607604)
    22(11738704-11758472)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG113193
    ome1    		 dipeptidyl-peptidase IV3
    omega1    		 35(a)
    (best of 2)3
    45.73(n)1
    35.83(a)1    		   442971  NM_080000.31  NP_524739.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea T23F1.7b3
    dpf-21    		 Protein DPF-21 30(a)
    (best of 3)3
    45.9(n)1
    33.55(a)1    		   V(15473968-15478599)3
    1815791  NM_078060.51  NP_510461.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes DAP21 Dap2p 44.65(n)
    32.42(a)    		   856423   NP_011893.1 


    ENSEMBL Gene Tree for FAP (if available)
    TreeFam Gene Tree for FAP (if available) 

    Paralogs
    for FAP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAP gene
    DPP82  DPP102  DPP62  DPP92  DPP42  
    3 SIMAP similar genes for FAP using alignment to 6 protein entries:     SEPR_HUMAN (see all proteins):
    DPP4    DPP6    DPP10

    FAP for paralogs           About GeneDecksing



    Genomic Variants
    for FAP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1177 NCBI SNPs in FAP are shown (see all 1177)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1876600501,2
    		--163026782(+) AATCTC/GAAAGC 1 -- ds50010--------
    rs1437671301,2
    		--163026862(+) AAGGAA/GTCTGA 1 -- ds50010--------
    rs1925143071,2
    		--163026936(+) GAAATG/TTAATA 1 -- ds50010--------
    rs1174934281,2
    		--163026985(+) CAAACG/ATGATT 1 -- ds50011Minor allele frequency- A:0.01EA 120
    rs1849190521,2
    		--163026998(+) CTTGCA/GTTTTC 1 -- ds50010--------
    rs75606921,2
    		H--163027063(+) TGACAG/CAAATC 1 -- ds50014Minor allele frequency- C:0.00NS EA 402
    rs1379129601,2
    		--163027081(+) ACTTCC/TAGATT 1 -- ds50010--------
    rs801097301,2
    		C--163027182(+) GAATAC/GAGACA 1 -- ds50010--------
    rs1424551361,2
    		--163027271(+) ATGCAG/TGACTC 1 -- ut310--------
    rs1881170571,2
    		--163027309(+) GAAAAC/TGTAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FAP (163027194 - 163101661 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for FAP
         1 CNV: 4314

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAP
    DNA2.0 Custom Variant and Variant Library Synthesis for FAP

    Disorders / Diseases
    for FAP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FAP for disorders           About GeneDecksing

    OMIM gene information: 600403    OMIM disorders: --

    20/41 diseases for FAP (see all 41):    About MalaCards
    soft tissue sarcoma    sarcoma    infiltrative basal cell carcinoma    aphthous stomatitis
    melanoma    basal cell carcinoma    intraepithelial neoplasm    trichoepithelioma
    papillary thyroid carcinoma    stomatitis    fibromatosis    carcinoma
    squamous cell carcinoma    thyroid carcinoma    ovarian carcinoma    rheumatoid arthritis
    osteoarthritis    keloids    hepatitis c    gastric cancer

    1 disease from the University of Copenhagen DISEASES database for FAP:
    Pharyngitis

    10/19 Novoseek disease relationships for FAP gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    stromal tumors 73.5 6 8201382 (2), 10593948 (1), 12542520 (1), 12183436 (1) (see all 5)
    epithelial tumor 48.7 5 18095711 (2), 10593948 (1), 8391923 (1), 7519584 (1)
    metastasis 47 28 12963128 (4), 16196122 (4), 17363526 (3), 14707457 (2) (see all 15)
    melanoma 46.7 26 12542520 (4), 9065413 (3), 7923219 (3), 9247085 (2) (see all 12)
    cancer 44.1 54 17047060 (5), 9139873 (2), 17363526 (2), 18787344 (2) (see all 29)
    carcinoma ductal 34.5 7 11241314 (3), 9758365 (2), 17047060 (1), 14524536 (1)
    tumors 32.2 59 17363526 (7), 12183436 (4), 15713998 (3), 15087384 (3) (see all 22)
    sarcoma 26.3 5 8391923 (2), 7519584 (1), 7911242 (1), 19817894 (1)
    skin tumor 25.5 3 12542520 (1), 16420310 (1)
    carcinoma 24.2 9 9065413 (1), 18787344 (1), 15713998 (1), 12183436 (1) (see all 6)

    Human Genome Epidemiology (HuGE) Navigator: FAP (173 documents)

    Export disorders for FAP gene to outside databases

    Publications
    for FAP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAP gene, integrated from 9 sources (see all 139):
    (articles sorted by number of sources associating them with FAP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of seprase: a serine integral membrane protease from human melanoma. (PubMed id 9247085)1, 2, 3, 9 Goldstein L.A.... Chen W.-T. (1997)
    2. Identification of the 170-kDa melanoma membrane-bound gelatinase (seprase) as a serine integral membrane protease. (PubMed id 9065413)1, 2, 9 Pineiro-Sanchez M.L....Chen W.-T. (1997)
    3. Seprase, a membrane-type serine protease, has different expression patterns in intestinal- and diffuse-type gastric cancer. (PubMed id 14707457)1, 3, 9 Okada K....Mitsumata M. (2003)
    4. Fibroblast activation protein: purification, epitope mapping and induction by growth factors. (PubMed id 7519584)1, 2, 9 Rettig W.J.... Old L.J. (1994)
    5. The protease complex consisting of dipeptidyl peptidase IV and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices. (PubMed id 16651416)1, 2, 9 Ghersi G....Chen W.T. (2006)
    6. Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers. (PubMed id 7911242)1, 2, 9 Scanlan M.J.... Rettig W.J. (1994)
    7. Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alpha. (PubMed id 15809306)1, 2, 9 Aertgeerts K....Tennant M.G. (2005)
    8. Identification of an alternatively spliced seprase mRNA that encodes a novel intracellular isoform. (PubMed id 10644713)1, 2, 9 Goldstein L.A. and Chen W.-T. (2000)
    9. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for FAP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FAP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2191 HGNC: 3590 AceView: FAP Ensembl:ENSG00000078098 euGenes: HUgn2191
    ECgene: FAP H-InvDB: FAP

    Other Databases showing FAP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FAP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FAP Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for FAP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FAP gene:
    Search GeneIP for patents involving FAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    for FAP gene

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    About This Section

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