Aliases for FANK1 Gene
Aliases for FANK1 Gene
External Ids for FANK1 Gene
- HGNC: 23527
- Entrez Gene: 92565
- Ensembl: ENSG00000203780
- OMIM: 611640
- UniProtKB: Q8TC84
Previous GeneCards Identifiers for FANK1 Gene
- GC10P127159
- GC10P127575
- GC10P121274
Summaries for FANK1 Gene
GeneCards Summary for FANK1 Gene
FANK1 (Fibronectin Type III And Ankyrin Repeat Domains 1) is a Protein Coding gene. An important paralog of this gene is ANKS6.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FANK1 Gene
Genomics for FANK1 Gene
Regulatory Elements for FANK1 Gene
Enhancers for FANK1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH10G125972 | 1.2 | Ensembl ENCODE | 11 | +77.3 | 77251 | 1.2 | ATF1 BRCA1 FOS SP3 ZHX2 TSHZ1 ZNF518A STAT3 SP7 ZNF146 | UROS FANK1 FANK1-AS1 GC10M126013 |
| GH10G125868 | 1 | ENCODE dbSUPER | 11.1 | -27.7 | -27658 | 0.2 | CTCF PKNOX1 FOXA2 RAD21 ZNF664 GATA3 SCRT2 SMC3 ZNF143 TCF7L2 | RNU2-42P FANK1 BCCIP UROS ENSG00000277371 |
| GH10G126012 | 1.1 | Ensembl ENCODE | 8.7 | +118.4 | 118380 | 3.7 | HDAC1 FOXA2 TBL1XR1 INSM2 RAD21 TCF12 GATA2 EGR1 SCRT2 FOS | UROS FANK1 GC10M126013 FANK1-AS1 |
| GH10G125982 | 0.9 | Ensembl ENCODE | 9.8 | +86.8 | 86820 | 1.7 | CTCF ZNF654 ZNF792 TRIM22 REST ZIC2 EP300 RAD21 SMARCA4 ZNF143 | UROS FANK1 FANK1-AS1 GC10M126013 |
| GH10G125870 | 0.8 | ENCODE dbSUPER | 10.9 | -24.5 | -24515 | 2.4 | OSR2 PRDM6 CEBPB FEZF1 PRDM10 PRDM4 TRIM28 | UROS FANK1 DHX32 MMP21 ENSG00000277371 GC10P125882 GC10P125883 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FANK1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FANK1 gene promoter:
Regulatory Element Products
Genomic Location for FANK1 Gene
- Chromosome:
- 10
- Start:
- 125,896,224 bp from pter
- End:
- 126,009,592 bp from pter
- Size:
- 113,369 bases
- Orientation:
- Plus strand
Genomic View for FANK1 Gene
Genes around FANK1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q26.2 by Ensembl
- 10q26.2 by Entrez Gene
- 10q26.2 by HGNC
FANK1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FANK1 Gene
Proteins for FANK1 Gene
-
Protein details for FANK1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TC84-FANK1_HUMAN
- Recommended name:
- Fibronectin type 3 and ankyrin repeat domains protein 1
- Protein Accession:
- Q8TC84
- Q6UXY9
- Q6X7T6
Protein attributes for FANK1 Gene
- Size:
- 345 amino acids
- Molecular mass:
- 38341 Da
- Quaternary structure:
- No Data Available
Protein Expression for FANK1 Gene
Post-translational modifications for FANK1 Gene
Other Protein References for FANK1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001337868.1
- NP_660278.3
- XP_005270337.1
- XP_006718121.1
- XP_006718127.1
- XP_011538650.1
- XP_011538651.1
- XP_011538652.1
- XP_011538653.1
- XP_011538658.1
- XP_011538659.1
- XP_011538660.1
- XP_011538662.1
- XP_011538663.1
- XP_011538664.1
- XP_011538665.1
- XP_016872405.1
- XP_016872406.1
- XP_016872407.1
- XP_016872408.1
- XP_016872409.1
- XP_016872410.1
- XP_016872411.1
- XP_016872412.1
- XP_016872413.1
- XP_016872414.1
- XP_016872415.1
Antibody Products
- Novus Biologicals Antibodies for FANK1
- Invitrogen Antibodies for FANK1
- Search GeneTex for Antibodies for FANK1
-
Santa Cruz Biotechnology (SCBT) Antibodies for FANK1
Protein Products
-
OriGene Purified Proteins for FANK1
- Search Origene for MassSpec and Protein Over-expression Lysates for FANK1
- Origene Custom Protein Services for FANK1
- ProSpec Recombinant Proteins for FANK1
- Search GeneTex for Proteins for FANK1
Assay Products
No data available for DME Specific Peptides for FANK1 Gene
Domains & Families for FANK1 Gene
Gene Families for FANK1 Gene
Protein Domains for FANK1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FANK1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FANK1 Gene
Function for FANK1 Gene
Phenotypes for FANK1 Gene
- GenomeRNAi human phenotypes for FANK1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FANK1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FANK1 gene
- Search ViGene Biosciences for FANK1
CRISPR Products
-
OriGene CRISPR knockouts for FANK1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FANK1
- GenScript: Design CRISPR guide RNA sequences for FANK1
miRNA Products
- Search ViGene Biosciences for FANK1
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for FANK1
- Browse OriGene Inhibitory RNA Products For FANK1
-
ViGene Biosciences ready-to-package AAV shRNAs for FANK1 gene
Clone Products
-
OriGene ORF clones in human for FANK1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FANK1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for FANK1
-
ViGene Biosciences adenoviral particle packaged cDNA for FANK1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FANK1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FANK1 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FANK1 Gene
Localization for FANK1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FANK1 Gene
- Nucleus. Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for FANK1 Gene
No Data Available
No data available for Pathways by source and SIGNOR curated interactions for FANK1 Gene
Transcripts for FANK1 Gene
mRNA/cDNA for FANK1 Gene
- (27) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (57) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FANK1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FANK1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FANK1
- GenScript: Design CRISPR guide RNA sequences for FANK1
miRNA Products
- Search ViGene Biosciences for FANK1
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for FANK1
- Browse OriGene Inhibitory RNA Products For FANK1
-
ViGene Biosciences ready-to-package AAV shRNAs for FANK1 gene
Clone Products
-
OriGene ORF clones in human for FANK1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FANK1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for FANK1 Gene
mRNA differential expression in normal tissues according to GTEx for FANK1 Gene
This gene is overexpressed in Testis (x12.9).
This gene is overexpressed in Peripheral blood mononuclear cells (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FANK1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of FANK1 Gene:
FANK1SOURCE GeneReport for Unigene cluster for FANK1 Gene:
Hs.352591mRNA Expression by UniProt/SwissProt for FANK1 Gene:
Q8TC84-FANK1_HUMAN
Tissue specificity:
Mostly restricted to testis.
Evidence on tissue expression from TISSUES for FANK1 Gene
- Stomach(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for FANK1
-
OriGene qPCR primer pairs for FANK1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FANK1 Gene
Orthologs for FANK1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FANK1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FANK1 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fank1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fank1 34 16 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FANK1 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FANK1 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FANK1 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | FANK1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fank1 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.31182 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fank1 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG42534 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | nphp-2 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.7190 35 |
|
OneToOne |
- Species where no ortholog for FANK1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FANK1 Gene
(11) SIMAP similar genes for FANK1 Gene using alignment to 7 proteins:
Variants for FANK1 Gene
| SNP ID | Clin | Chr 10 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000018863 | -- | 125,990,355(+) | CACCA(C/T)TGCAC | intron-variant, utr-variant-5-prime | |
| rs1000037241 | -- | 125,902,183(+) | GTGCA(A/G)CACAC | intron-variant | |
| rs1000087434 | -- | 125,953,615(+) | GCCCT(C/G/T)AGATT | intron-variant | |
| rs1000118253 | -- | 125,897,920(+) | GGGAG(A/G)CTGAG | intron-variant, upstream-variant-2KB | |
| rs1000171849 | -- | 125,968,463(+) | ATGAG(A/T)TTTGG | intron-variant |
Residual Variation Intolerance Score:
76.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.59;
56.23% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FANK1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FANK1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FANK1 Gene
Disorders for FANK1 Gene
Relevant External Links for FANK1
No disorders were found for FANK1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FANK1 Gene
Publications for FANK1 Gene
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
- Genes to diseases (G2D) computational method to identify asthma candidate genes. (PMID: 18682798) Tremblay K. … Laprise C. (PLoS ONE 2008) 3 46 64
- Fank1 is a testis-specific gene encoding a nuclear protein exclusively expressed during the transition from the meiotic to the haploid phase of spermatogenesis. (PMID: 17604233) Zheng Z. … Yan W. (Gene Expr. Patterns 2007) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
Products for FANK1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
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- Browse Immunoprecipitation Assays
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for FANK1
- Search Origene for MassSpec and Protein Over-expression Lysates for FANK1
- Origene Custom Protein Services for FANK1
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FANK1
- Browse OriGene Inhibitory RNA Products For FANK1
- OriGene qPCR primer pairs and template standards for FANK1
- OriGene qPCR primer pairs for FANK1
- OriGene CRISPR knockouts for FANK1
- OriGene ORF clones in human for FANK1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FANK1
- GenScript: Next-day shipping cDNA ORF clone for FANK1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for FANK1
- GenScript Custom Assay Services for FANK1
- GenScript Custom overexpressing Cell Line Services for FANK1
- GenScript: Design CRISPR guide RNA sequences for FANK1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for FANK1
- Sino Biological Human cDNA Clone for FANK1
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for FANK1
- Novus Biologicals proteins and lysates for FANK1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for FANK1
- ViGene Biosciences adenoviral particle packaged cDNA for FANK1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FANK1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FANK1 gene
- Search ViGene Biosciences for FANK1
- Santa Cruz Biotechnology (SCBT) Antibodies for FANK1
- Search Santa Cruz Biotechnology (SCBT) for FANK1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FANK1
- Horizon Cell Lines for FANK1
- Cyagen custom Knockout/knockin (KOKI) mouse models for FANK1
- VectorBuilder custom plasmid, inducible vectors for FANK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FANK1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FANK1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer