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Aliases for FANK1 Gene

Aliases for FANK1 Gene

  • Fibronectin Type III And Ankyrin Repeat Domains 1 2 3
  • Fibronectin Type 3 And Ankyrin Repeat Domains 1 2 3
  • Fibronectin Type 3 And Ankyrin Repeat Domains Protein 1 3
  • 1700007B22Rik 3
  • HSD13 3

External Ids for FANK1 Gene

Summaries for FANK1 Gene

GeneCards Summary for FANK1 Gene

FANK1 (Fibronectin Type III And Ankyrin Repeat Domains 1) is a Protein Coding gene. An important paralog of this gene is TANC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FANK1 Gene

Genomics for FANK1 Gene

Genomic Location for FANK1 Gene

Start:
125,896,539 bp from pter
End:
126,009,592 bp from pter
Size:
113,054 bases
Orientation:
Plus strand

Genomic View for FANK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FANK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FANK1 Gene

Regulatory Elements for FANK1 Gene

Proteins for FANK1 Gene

  • Protein details for FANK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TC84-FANK1_HUMAN
    Recommended name:
    Fibronectin type 3 and ankyrin repeat domains protein 1
    Protein Accession:
    Q8TC84
    Secondary Accessions:
    • Q6UXY9
    • Q6X7T6

    Protein attributes for FANK1 Gene

    Size:
    345 amino acids
    Molecular mass:
    38341 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FANK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FANK1 Gene

Proteomics data for FANK1 Gene at MOPED

Post-translational modifications for FANK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FANK1 Gene

No data available for DME Specific Peptides for FANK1 Gene

Domains for FANK1 Gene

Gene Families for FANK1 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
  • FN3 :Fibronectin type III domain containing

Protein Domains for FANK1 Gene

UniProtKB/Swiss-Prot:

FANK1_HUMAN
Domain:
  • Contains 1 fibronectin type-III domain.:
    • Q8TC84
Similarity:
  • Contains 6 ANK repeats.:
    • Q8TC84
genes like me logo Genes that share domains with FANK1: view

Function for FANK1 Gene

Gene Ontology (GO) - Molecular Function for FANK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FANK1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FANK1 Gene

Localization for FANK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FANK1 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FANK1 Gene COMPARTMENTS Subcellular localization image for FANK1 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FANK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with FANK1: view

Pathways for FANK1 Gene

SuperPathways for FANK1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FANK1 Gene

None

No data available for Pathways by source for FANK1 Gene

Transcripts for FANK1 Gene

Unigene Clusters for FANK1 Gene

Fibronectin type III and ankyrin repeat domains 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FANK1 Gene

No ASD Table

Relevant External Links for FANK1 Gene

GeneLoc Exon Structure for
FANK1
ECgene alternative splicing isoforms for
FANK1

Expression for FANK1 Gene

mRNA expression in normal human tissues for FANK1 Gene

mRNA differential expression in normal tissues according to GTEx for FANK1 Gene

This gene is overexpressed in Testis (12.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FANK1 Gene

SOURCE GeneReport for Unigene cluster for FANK1 Gene Hs.352591

mRNA Expression by UniProt/SwissProt for FANK1 Gene

Q8TC84-FANK1_HUMAN
Tissue specificity: Mostly restricted to testis.
genes like me logo Genes that share expressions with FANK1: view

Orthologs for FANK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FANK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FANK1 36
  • 99.61 (n)
  • 99.13 (a)
FANK1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FANK1 36
  • 85.66 (n)
  • 90.7 (a)
FANK1 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FANK1 36
  • 90.28 (n)
  • 92.56 (a)
FANK1 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fank1 36
  • 86.01 (n)
  • 88.92 (a)
Fank1 16
Fank1 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FANK1 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FANK1 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fank1 36
  • 86.2 (n)
  • 88.63 (a)
lizard
(Anolis carolinensis)
Reptilia FANK1 37
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.31182 36
tropical clawed frog
(Silurana tropicalis)
Amphibia fank1 36
  • 66.98 (n)
  • 63.27 (a)
zebrafish
(Danio rerio)
Actinopterygii fank1 36
  • 58.7 (n)
  • 54.97 (a)
fank1 37
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42534 37
  • 5 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nphp-2 37
  • 6 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7190 37
  • 48 (a)
OneToOne
Species with no ortholog for FANK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FANK1 Gene

ENSEMBL:
Gene Tree for FANK1 (if available)
TreeFam:
Gene Tree for FANK1 (if available)

Paralogs for FANK1 Gene

genes like me logo Genes that share paralogs with FANK1: view

Variants for FANK1 Gene

Sequence variations from dbSNP and Humsavar for FANK1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1666 - 126,009,385(-) TAATA(A/C)GGAGA missense, reference
rs885565 -- 125,998,228(-) AGTGC(C/T)CAAGC intron-variant
rs1342234 -- 125,894,783(-) AAGTG(A/G)CAAGA upstream-variant-2KB
rs1857121 -- 125,913,742(-) AGGCT(C/G)AGGGC intron-variant
rs1857122 -- 125,913,677(-) ATTCC(A/T)ATACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FANK1 Gene

Variant ID Type Subtype PubMed ID
nsv428241 CNV Loss 18775914
dgv324e1 CNV Complex 17122850
nsv8738 CNV Loss 18304495
dgv179n67 CNV Loss 20364138
nsv820776 CNV Duplication 20802225
esv2623784 CNV Gain 19546169
esv22980 CNV Gain 19812545
esv2742962 CNV Deletion 23290073
esv8034 OTHER Inversion 19470904
esv6291 OTHER Inversion 19470904
esv2485694 CNV Gain 19546169
esv2742984 CNV Deletion 23290073
esv2742995 CNV Deletion 23290073
esv33389 CNV Gain 17666407
nsv527133 CNV Loss 19592680
esv25941 CNV Gain 19812545

Relevant External Links for FANK1 Gene

HapMap Linkage Disequilibrium report
FANK1

Disorders for FANK1 Gene

Relevant External Links for FANK1

Genetic Association Database (GAD)
FANK1
Human Genome Epidemiology (HuGE) Navigator
FANK1
genes like me logo Genes that share disorders with FANK1: view

No data available for UniProtKB/Swiss-Prot for FANK1 Gene

Publications for FANK1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Fank1 is a testis-specific gene encoding a nuclear protein exclusively expressed during the transition from the meiotic to the haploid phase of spermatogenesis. (PMID: 17604233) Zheng Z. … Yan W. (Gene Expr. Patterns 2007) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for FANK1 Gene

Sources for FANK1 Gene

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