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FANCM Gene

protein-coding GIFtS: 62

GC14P044675

Fanconi anemia, complementation group M
(Previous name: KIAA1596 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: KIAA1596)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.6.1.- ^³
FAAP250 ^², ³
KIAA1596 ^¹, ², ³, ⁵
MGC176453 ^²

Descriptions
ATP-dependent RNA helicase FANCM ^³
Fanconi anemia, complementation group M ^²
Fanconi anemia-associated polypeptide of 250 kDa ^³
Protein FACM ^³
Protein Hef ortholog ^³

External Ids
HGNC: 23168¹
Entrez Gene: 57697²
UniProtKB: Q8IYD8³
Ensembl: ENSG00000187790⁷

Search outside databases for aliases for FANCM gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FANCM:

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1

(also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM

and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi

anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability,

hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA

repair. The members of the Fanconi anemia complementation group do not share sequence similarity;

they are related by their assembly into a common nuclear protein complex. This gene encodes the

protein for complementation group M. [provided by RefSeq]

UniProtKB/Swiss-Prot: FANCM_HUMAN, Q8IYD8

Function: ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA

but not to dsDNA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FANCM gene

Entrez Gene cytogenetic band: 14q21.3 Ensembl cytogenetic band: 14q21.3 HGNC cytogenetic band: 14q21.3

FANCM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P044675: (about GC identifiers)

Start:	44,674,886 bp from pter
End:	44,739,840 bp from pter
Size:	64,955 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000014.7 NT_026437.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: FANCM_HUMAN, Q8IYD8 (See protein sequence)

Recommended Name: Fanconi anemia group M protein

Size: 2048 amino acids; 232191 Da

Subunit: Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF,

FANCG, FANCL/PHF9, FANCM and FAAP24. The complex is not found in FA patients. Interacts with

FAAP24. Interacts with EME1

Subcellular location: Nucleus

Sequence caution: Sequence=BAB13422.1; Type=Miscellaneous discrepancy; Note=Intron retention;

Secondary accessions: Q3YFH9 Q8N9X6 Q9HCH6

Alternative splicing: 2 isoforms: Q8IYD8-1 Q8IYD8-2

Post-translational modifications:

Phosphorylated; hyperphosphorylated in response to genotoxic stress¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_065988.1

ENSEMBL proteins:

ENSP00000267430

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (FANCM)
	Human Recombinant Proteins from Abnova (FANCM)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

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Antibodies for FANCM:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (FANCM), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FANCM)
	Novus Biologicals Antibodies for FANCM

Assays for FANCM:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8IYD8

ProtoNet protein and cluster: Q8IYD8

2 Blocks protein families:

IPB002464 ATP-dependent helicase

IPB006166 ERCC4 domain

UniProtKB/Swiss-Prot: FANCM_HUMAN, Q8IYD8

Similarity: Belongs to the DEAD box helicase family. DEAH subfamily

Similarity: Contains 1 helicase ATP-binding domain

Similarity: Contains 1 helicase C-terminal domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FANCM)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_020937

Applied Biosystems Silencer® siRNAs for FANCM

Sigma-Aldrich siRNA for FANCM

Sigma-Aldrich shRNA Panels and shRNA for FANCM

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FANCM
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_020937
Myc/DDK tagged cDNA clone in CMV expression vector: NM_020937
untagged cDNA clones in CMV expression vector (see all 3): AK093422

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_020937

UniProtKB/Swiss-Prot: FANCM_HUMAN, Q8IYD8

Function: ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA

but not to dsDNA

Enzyme Number (IUBMB): EC 3.6.1.-

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003677	DNA binding	IEA	--
GO:0004386	helicase activity	IEA	--
GO:0004518	nuclease activity	IEA	--
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for FANCM

5/15 Interacting proteins for FANCM (Q8IYD8² ENSP00000267430³) via UniProtKB, MINT, and/or STRING (see all 15 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FANCL	Q9NW38², ENSP00000233741³	MINT-4789189 MINT-4789279 MINT-4789226 STRING (score=.954)
C17orf70	Q0VG06², ENSP00000333283³	MINT-4789189 MINT-4789279 MINT-4789226 STRING (score=.943)
FANCA	O15360², ENSP00000373952³	MINT-4789189 MINT-4789226 STRING (score=.978)
FANCG	O15287², ENSP00000367910³	MINT-4789189 MINT-4789226 STRING (score=.899)
FANCB	Q8NB91²	MINT-4789189 MINT-4789279 MINT-4789226

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006281	DNA repair	IEA	--
GO:0006974	response to DNA damage stimulus	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FANCM

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FANCM)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_020937

Sigma-Aldrich siRNA for FANCM

Sigma-Aldrich shRNA Panels and shRNA for FANCM

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_020937

REFSEQ mRNAs for FANCM gene:

NM_020937.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_020937

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_020937
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_020937
                                 untagged cDNA clones in CMV expression vector (see all 3): AK093422

Additional cDNA sequence:

AB046816.1 AK001672.1 AK093422.1 AL833656.1 BC036056.1 BC140776.1 BC144511.1 DQ140356.1

8 DOTS entries:

DT.100019588 DT.431945 DT.99998272 DT.120757446 DT.75133338 DT.75130572 DT.40125814 DT.40200442

24/49 AceView cDNA sequences (see all 49 ):

AI565351 AA412595 AA789146 AW517262 AU132940 AI745662 BX282356 CA976036

AI673728 AA424588 AX748116 AA829389 AL833656 BX280532 AK093422 BE350003

BF516426 AW170807 AA953838 BQ434709 BC036056 AA424633 AA766196 AA431595

highest scoring ESTs for FANCM:

AA044905 AA424588 AA424633 AB046816 AI204384 AI673728 AK001672 AL833656 AU154369 AW517262

Unigene Cluster for FANCM:

Fanconi anemia, complementation group M

Hs.509229 [show with all ESTs]

Unigene Representative Sequence: NM_020937

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for FANCM

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14a	·	14b	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22a	·
SP1:																											-																						-
SP2:																							-				-																						-
SP3:
SP4:
SP5:

ExUns:	22b	^	23a	·	23b	^	24a	·	24b	·	24c
SP1:
SP2:
SP3:
SP4:
SP5:					-

About this scheme

ECgene alternative splicing isoforms for FANCM

1 Ensembl transcript including schematic representation:

ENST00000267430

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FANCM expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FANCM

¹ / ² / ³

10 probe-sets matching FANCM gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
66557_at²^{, 3}	U95-C	1	1.00	1.00	0.70	0.88	AA829389	0.60	1.00	0.82	1
53650_s_at²^{, 3}	U95-C	1	1.00	1.00	0.80	1.18	AI745662	0.60	1.00	0.82	1
53645_at²^{, 3}	U95-C	1	1.00	1.00	0.76	0.97	AA044905	1.00	1.00	1.00	1
234733_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AK001672	0.80	1.00	0.91	1
231971_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AB046816	0.80	1.00	0.91	1
242711_x_at²^{, 3}	U133-B	1	0.55	1.00	--	--	AI745662	0.60	1.00	0.82	1
234733_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
231971_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1554277_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
242711_x_at²	U133Plus2	1	0.55	1.00	--	--	--	--	--	--	--

GeneDecks FANCM for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CATTTTTCCC

SOURCE GeneReport for Unigene cluster: Hs.509229

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FANCM gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FANCM¹	--	Fanconi anemia, complementation group M	87.31(n) 79.89(a)	480307 XM_537429.2 XP_537429.2
chimpanzee (Pan troglodytes)	FANCM¹	--	Fanconi anemia, complementation group M	99.27(n) 98.78(a)	452885 XM_509928.2 XP_509928.2
mouse (Mus musculus)	Fancm^{1, 5}	12 (29.00 cM)⁵	Fanconi anemia, complementation group M^{1, 5}	75.4(n)¹ 66.8(a)¹	104806¹ NM_178912.3¹ NP_849243.2¹ AI427100⁵ AK028941⁵ (see all 21)
baker's yeast (Saccharomyces cerevisiae)	MPH1(YIR002C)⁴	9(360393-357412)	Member of the DEAH family of helicases, functions in more	--	854818 NP_012267.1
tropical clawed frog (Silurana tropicalis)	Str.18400²	--	Transcribed sequence with weak similarity to protein more	77.54(n)	AL965241.2

About this table Species with no ortholog for FANCM

ENSEMBL Gene Tree for FANCM

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/169 NCBI SNPs in FANCM are shown (see all 169 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 80)

AB	SNP ID	Valid	Chr 14 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1367580^1,2	A,C,F,H,O	44714339(+)	`ATTCTG/TTAGAT`	1	V/L	mis¹ ese³		15		MN EU EA WA NA	1622
	rs3736772^1,2	C,F,H	44735218(-)	`CTGCGG/CAAGTC`	1	A/P	mis¹ ese³		13		EA EU WA	2750
--	rs226980^1,2	A,C	44740138(-)	`gacttC/Ggtgat`	1	--	ng3¹		0	--	--	--	--
--	rs17709322^1,2	F	44739380(+)	`GATTCT/GAAATA`	1	--	ut3¹		3		NA	142
	rs8017226^1,2	F,H	44714377(+)	`ATTTTT/CCAAGA`	1	F/F	syn¹ ese³		4		EU EA WA	418
	rs8018014^1,2	F,H	44738955(+)	`TCTGAT/CATATA`	1	D/D	syn¹ ese³		4		EU EA WA	420
	rs7142192^1,2	F,H	44728165(+)	`AAGCAG/AAGCAA`	1	Q/Q	syn¹ ese³		4		EU EA WA	416
	rs11845507^1,2	A,C,F,H	44721715(+)	`GATACG/ACACAT`	1	--	int¹		4		EU EA WA	420
	rs911041^1,2	A,C,F,H	44730349(-)	`ctgctT/Cagata`	1	--	int¹		7		EU EA WA NA	562
	rs226981^1,2	C,F,H,O	44732075(-)	`ACAGTA/GGCTTA`	1	--	int¹		11		EU EA WA NA	982

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HapMap Linkage Disequilibrium images for FANCM (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 609644

UniProtKB/Swiss-Prot: FANCM_HUMAN, Q8IYD8

Defects in FANCM are a cause of Fanconi anemia (FA) [MIM:227650]. FA is a genetically

heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse

assortment of congenital malformations, and a predisposition to the development of malignancies.

At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal

instability (increased chromosome breakage), and defective DNA repair

1 Novoseek disease relationship for FANCM gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fanconis anemia	89.85	3	18285517 (1), 19158388 (1)

About this table

GeneTests: FANCM

Fanconi Anemia

Human Gene Mutation Database: FANCM

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/18 PubMed articles for FANCM gene (see all 18 ):

A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. (PubMed id 16116422)^{2, 3, 4} Meetei A.R....Wang W. (2005)
Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)^{2, 3, 4} Nagase T....Ohara O. (2000)
The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway. (PubMed id 16116434)^{3, 4} Mosedale G.... Patel K.J. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
FANCM of the Fanconi anemia core complex is required for both monoubiquitination and DNA repair. (PubMed id 18285517)^{1, 3} Xue Y....Wang W. (2008)
Regulated degradation of FANCM in the Fanconi anemia pathway during mitosis. (PubMed id 19270156)³ Kee Y....D'Andrea A. (2009)
FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex. (PubMed id 18995830)³ Collis S.J....Boulton S.J. (2008)
Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24. (PubMed id 18174376)³ Kim J.M....D'Andrea A.D. (2008)
The Fanconi anemia protein FANCM can promote branch migration of Holliday junctions and replication forks. (PubMed id 18206976)³ Gari K....Constantinou A. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 57697	HGNC: 23168	AceView: KIAA1596	Ensembl:ENSG00000187790	euGenes: HUgn57697
ECgene: FANCM	H-InvDB: FANCM

(According to HUGE)
About This Section

HUGE: KIAA1596

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for FANCM	Genetics and Cytogenetics in Oncology and Haematology
Fanconi Anemia Mutation Database	http://www.rockefeller.edu/fanconi/mutate/
GeneReviews	http://www.genetests.org/query?gene=FANCM

Licensable Technologies for FANCM
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FANCM:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FANCM-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FANCM		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for FANCM		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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FANCM Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for FANCM

Summaries
for FANCM

Genomic Location
for FANCM

Proteins
for FANCM

Protein Domains/
Families
for FANCM

Gene Function
for FANCM

Pathways & Interactions
for FANCM

Drugs & Compounds
for FANCM

Transcripts
for FANCM

Expression
for FANCM

Orthologs
for FANCM

Paralogs
for FANCM

SNPs/Variants
for FANCM

Disorders & Mutations
for FANCM

Medical News
for FANCM

Publications
for FANCM

Search for FANCM

Genome Databases showing FANCM

Other Databases showing FANCM

Specialized Databases showing FANCM

Licensable Technologies
for FANCM

Services
for FANCM

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FANCM Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor FANCM

Summariesfor FANCM

Genomic Locationfor FANCM

Proteinsfor FANCM

Protein Domains/Familiesfor FANCM

Gene Functionfor FANCM

Pathways & Interactionsfor FANCM

Drugs & Compoundsfor FANCM

Transcriptsfor FANCM

Expression for FANCM

Orthologsfor FANCM

Paralogsfor FANCM

SNPs/Variantsfor FANCM

Disorders & Mutationsfor FANCM

Medical Newsfor FANCM

Publicationsfor FANCM

Search for FANCM

Genome Databases showing FANCM

Other Databases showing FANCM

Specialized Databases showing FANCM

Licensable Technologiesfor FANCM

Servicesfor FANCM

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FANCM

Summaries
for FANCM

Genomic Location
for FANCM

Proteins
for FANCM

Protein Domains/
Families
for FANCM

Gene Function
for FANCM

Pathways & Interactions
for FANCM

Drugs & Compounds
for FANCM

Transcripts
for FANCM

Expression
for FANCM

Orthologs
for FANCM

Paralogs
for FANCM

SNPs/Variants
for FANCM

Disorders & Mutations
for FANCM

Medical News
for FANCM

Publications
for FANCM

Licensable Technologies
for FANCM

Services
for FANCM