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FANCL Gene

protein-coding GIFtS: 62

GC02M058298

Fanconi anemia, complementation group L
(Previous name: PHD finger protein 9 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PHF9)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 6.3.2.- ^³
FAAP43 ^², ³
FLJ10335 ^¹, ²
PHF9 ^², ³, ⁵
POG ^²

Descriptions
Fanconi anemia group L protein ^³
Fanconi anemia, complementation group L ^²
Fanconi anemia-associated polypeptide of 43 kDa ^³
PHD finger protein 9 ^¹, ²

External Ids
HGNC: 20748¹
Entrez Gene: 55120²
UniProtKB: Q9NW38³
Ensembl: ENSG00000115392⁷

Search outside databases for aliases for FANCL gene

Previous GC identifers: GC00U912964 GC02M058360

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FANCL:

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1

(also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM

and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi

anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability,

hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA

repair. The members of the Fanconi anemia complementation group do not share sequence similarity;

they are related by their assembly into a common nuclear protein complex. This gene encodes the

protein for complementation group L. Alternative splicing results in two transcript variants

encoding different isoforms. [provided by RefSeq]

UniProtKB/Swiss-Prot: FANCL_HUMAN, Q9NW38

Function: Ubiquitin ligase protein that mediates ubiquitination of FANCD2, a key step in the DNA

damage pathway. May be required for proper primordial germ cell proliferation in the embryonic

stage, whereas it is probably not needed for spermatogonial proliferation after birth

Gene Wiki entry for FANCL

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FANCL gene

Entrez Gene cytogenetic band: 2p16.1 Ensembl cytogenetic band: 2p16.1 HGNC cytogenetic band: 2p16.1

FANCL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M058298: (about GC identifiers)

Start:	58,239,882 bp from pter
End:	58,322,018 bp from pter
Size:	82,137 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_022184.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FANCL_HUMAN, Q9NW38 (See protein sequence)

Recommended Name: E3 ubiquitin-protein ligase FANCL

Size: 375 amino acids; 42905 Da

Subunit: Interacts with GGN (By similarity). Belongs to the multisubunit FA complex composed of

FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. The complex is not found in FA

patients

Subcellular location: Cytoplasm. Nucleus

Caution: Although PubMed:12724401 reports that it contains a PHD-type zinc finger, it contains a

RING-type zinc finger. Moreover, PHD-type zinc fingers do not have any ubiquitin ligase activity

Secondary accessions: Q6GU60

REFSEQ proteins (2 alternative transcripts):

NP_001108108.1 NP_060532.2

ENSEMBL proteins:

ENSP00000233741 ENSP00000386097 ENSP00000385021 ENSP00000384046

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (FANCL)
	Human Recombinant Proteins from Abnova (FANCL)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

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Antibodies for FANCL:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for FANCL
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (FANCL), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FANCL)
	Novus Biologicals Antibodies for FANCL

Assays for FANCL:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9NW38

ProtoNet protein and cluster: Q9NW38

1 Blocks protein family: IPB001841 Zn-finger

UniProtKB/Swiss-Prot: FANCL_HUMAN, Q9NW38

Similarity: Contains 1 RING-type zinc finger

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FANCL)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001114636

Applied Biosystems Silencer® siRNAs for FANCL

Sigma-Aldrich siRNA and siRNA Panels for FANCL

Sigma-Aldrich shRNA Panels and shRNA for FANCL

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FANCL
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001114636
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001114636
untagged cDNA clones in CMV expression vector (see all 2): NM_001114636

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001114636

UniProtKB/Swiss-Prot: FANCL_HUMAN, Q9NW38

Function: Ubiquitin ligase protein that mediates ubiquitination of FANCD2, a key step in the DNA

damage pathway. May be required for proper primordial germ cell proliferation in the embryonic

stage, whereas it is probably not needed for spermatogonial proliferation after birth

Enzyme Number (IUBMB): EC 6.3.2.-

6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Fancl):

embryogenesis	endocrine/exocrine gland	growth/size	homeostasis/metabolism	lethality-prenatal/perinatal
reproductive system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0016874	ligase activity	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: FANCL_HUMAN, Q9NW38

Pathway: Protein modification; protein ubiquitination

Gene Network Central^TM Interacting Genes and Proteins Network for FANCL

5/50 Interacting proteins for FANCL (Q9NW38² ENSP00000233741³) via UniProtKB, MINT, and/or STRING (see all 50 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
C17orf70	Q0VG06², ENSP00000333283³	MINT-4789189 MINT-4789279 MINT-4789226 MINT-4789371 MINT-4789325 STRING (score=.963)
FANCB	Q8NB91², ENSP00000326819³	MINT-4789189 MINT-4789279 MINT-4789226 MINT-4789371 STRING (score=.901)
FANCA	O15360², ENSP00000373952³	MINT-4789189 MINT-4789226 MINT-4789325 STRING (score=.999)
FANCG	O15287², ENSP00000367910³	MINT-4789189 MINT-4789226 MINT-4789325 STRING (score=.998)
FANCM	Q8IYD8², ENSP00000267430³	MINT-4789189 MINT-4789279 MINT-4789226 STRING (score=.954)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006281	DNA repair	IEA	--
GO:0006974	response to DNA damage stimulus	IEA	--
GO:0019941	modification-dependent protein catabolic process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FANCL

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FANCL)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001114636

Sigma-Aldrich siRNA and siRNA Panels for FANCL

Sigma-Aldrich shRNA Panels and shRNA for FANCL

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001114636 NM_018062

REFSEQ mRNAs for FANCL gene (2 alternative transcripts):

NM_001114636.1 NM_018062.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001114636 NM_018062

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001114636
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001114636
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001114636

Additional cDNA sequence:

AK001197.1 AK225147.1 AK297736.1 AK309671.1 BC009042.1 BC037570.1 BC041627.1 BC054517.1

CR594145.1 CR597729.1

18 DOTS entries:

DT.75182666 DT.448234 DT.92387226 DT.120965414 DT.92440954 DT.100783920 DT.70103087 DT.86852791

DT.92440947 DT.95279769 DT.100689663 DT.100783923 DT.120965399 DT.100026572 DT.100035558 DT.448235

DT.92440943 DT.92440944

24/129 AceView cDNA sequences (see all 129 ):

AA258135 CD105578 BC037570 CR594145 AU126989 AL043470 CA841300 AA258395

AU132311 BP373332 AK001197 AA280291 BM786985 AW572256 BU156193 BU676880

BX444601 BU621773 NM_018062 AI342480 BC054517 CB156727 CF529786 BI916786

highest scoring ESTs for FANCL:

AL036481 AA232116 AK001197 AL043470 AU123628 AU126989 AU132311 AU133843 BC009042 BC037570

Unigene Cluster for FANCL:

Fanconi anemia, complementation group L

Hs.631890 [show with all ESTs]

Unigene Representative Sequence: BC037570

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000233741 ENST00000403295 ENST00000402135 ENST00000403676

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FANCL expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FANCL

¹ / ² / ³

4 probe-sets matching FANCL gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33125_at²^{, 3}	U95-A	1	1.00	1.00	0.93	1.15	AL043470	0.80	1.00	0.91	1
83634_at²^{, 3}	U95-E	1	1.00	1.00	0.97	0.85	AL036481	1.00	1.00	1.00	1
218397_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_018062	0.60	1.00	0.82	1
218397_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks FANCL for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.631890
Expression variation in blood from EXPOLDB for FANCL

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FANCL gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FANCL¹	--	Fanconi anemia, complementation group L	91.38(n) 89.94(a)	612161 XM_849891.1 XP_854984.1
chimpanzee (Pan troglodytes)	FANCL¹	--	Fanconi anemia, complementation group L	99.29(n) 99.2(a)	459251 XM_001157414.1 XP_001157414.1
cow (Bos taurus)	FANCL¹	--	Fanconi anemia, complementation group L	90.44(n) 87.94(a)	614512 NM_001076332.1 NP_001069800.1
rat (Rattus norvegicus)	Fancl¹	--	Fanconi anemia, complementation group L	82.53(n) 79.68(a)	305600 XM_223701.4 XP_223701.4
mouse (Mus musculus)	Fancl^{1, 5}	11⁵	Fanconi anemia, complementation group L^{1, 5}	83.42(n)¹ 79.41(a)¹	67030¹ NM_025923.2¹ NP_080199.1¹ AA183187⁵ AF513619⁵ (see all 18)

About this table Species with no ortholog for FANCL

ENSEMBL Gene Tree for FANCL

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/385 NCBI SNPs in FANCL are shown (see all 385 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 134)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2192690^1,2	A,C,F,H	58323846(-)	`AAAGTG/TTGGTG`	1	--	ng3¹		9	EU EA WA NA	2244
	rs6735296^1,2	C,F,H	58322264(+)	`TATTGA/TAAGAC`	1	--	ng3¹		6	MN EA EU WA	1670
	rs4395240^1,2	F,H	58323004(+)	`ACCTAG/CCAACA`	1	--	ng3¹		4	EU EA WA	418
	rs36059257^1,2	C,F	58284809(-)	`TGCTTC/TTGGTA`	2	S/F	mis¹		5	NA EU EA WA	470
	rs848291^1,2	C,F,H,O	58242200(-)	`AATTCC/TCAGTG`	2	S/S	syn¹ ese³		13	EU EA WA NA	1158
	rs1404460^1,2	A,C,F,H,O	58284672(-)	`ATCTAA/GAAATA`	1	--	int¹		8	MN EU EA WA NA	744
	rs2098344^1,2	A,C,F,H,O	58267255(-)	`AAGCCA/GGAAAA`	1	--	int¹		16	EU EA WA NA	1470
	rs768298^1,2	A,C,F,H,O	58264476(-)	`CCAACA/GTAGTC`	1	--	int¹		21	NA NS EU EA WA	1588
	rs1404459^1,2	A,C,F,O	58284914(-)	`CCCCTC/GTCCAG`	1	--	int¹ trp³		2	MN EA	1470
	rs3771216^1,2	A,C,F,H	58265344(+)	`TCTTAT/CAGGAA`	1	--	int¹		9	EA EU WA	2322

About this table

HapMap Linkage Disequilibrium images for FANCL (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 608111

UniProtKB/Swiss-Prot: FANCL_HUMAN, Q9NW38

Defects in FANCL are a cause of Fanconi anemia (FA) [MIM:227650]. FA is a genetically

heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse

assortment of congenital malformations, and a predisposition to the development of malignancies.

At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal

instability (increased chromosome breakage), and defective DNA repair

2 Novoseek disease relationships for FANCL gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fanconis anemia	94.11	2	16916645 (1), 16116424 (1)
hnscc	57.19	2	17409780 (1), 16466850 (1)

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GeneTests: FANCL

Fanconi Anemia

Human Gene Mutation Database: FANCL
Human Genome Epidemiology Navigator: FANCL (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/34 PubMed articles for FANCL gene (see all 34 ):

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{3, 4} Hillier L.W....Wilson R.K. (2005)
A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. (PubMed id 16116422)^{3, 4} Meetei A.R....Wang W. (2005)
X-linked inheritance of Fanconi anemia complementation group B. (PubMed id 15502827)^{3, 4} Meetei A.R....Joenje H. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
A novel ubiquitin ligase is deficient in Fanconi anemia. (PubMed id 12973351)^{3, 4} Meetei A.R.... Wang W. (2003)
A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome. (PubMed id 12724401)^{3, 4} Meetei A.R.... Wang W. (2003)
Hypermethylation of the FANCC and FANCL promoter regions in sporadic acute leukaemia. (PubMed id 18607065)³ Hess C.J....Waisfisz Q. (2008)
Comprehensive analysis of DNA repair gene variants and risk of meningioma. (PubMed id 18270339)³ Bethke L....Houlston R. (2008)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 55120	HGNC: 20748	AceView: FANCL	Ensembl:ENSG00000115392	euGenes: HUgn55120
ECgene: FANCL	H-InvDB: FANCL

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for FANCL	Genetics and Cytogenetics in Oncology and Haematology
Fanconi Anemia Mutation Database	http://www.rockefeller.edu/fanconi/mutate/jumpl.html
GeneReviews	http://www.genetests.org/query?gene=FANCL

Licensable Technologies for FANCL
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for FANCL:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FANCL-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
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	Predesigned and custom siRNAs for FANCL		Antibodies for FANCL
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for FANCL		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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FANCL Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for FANCL

Summaries
for FANCL

Genomic Location
for FANCL

Proteins
for FANCL

Protein Domains/
Families
for FANCL

Gene Function
for FANCL

Pathways & Interactions
for FANCL

Drugs & Compounds
for FANCL

Transcripts
for FANCL

Expression
for FANCL

Orthologs
for FANCL

Paralogs
for FANCL

SNPs/Variants
for FANCL

Disorders & Mutations
for FANCL

Medical News
for FANCL

Publications
for FANCL

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Genome Databases showing FANCL

Other Databases showing FANCL

Specialized Databases showing FANCL

Licensable Technologies
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Services
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FANCL Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor FANCL

Summariesfor FANCL

Genomic Locationfor FANCL

Proteinsfor FANCL

Protein Domains/Familiesfor FANCL

Gene Functionfor FANCL

Pathways & Interactionsfor FANCL

Drugs & Compoundsfor FANCL

Transcriptsfor FANCL

Expression for FANCL

Orthologsfor FANCL

Paralogsfor FANCL

SNPs/Variantsfor FANCL

Disorders & Mutationsfor FANCL

Medical Newsfor FANCL

Publicationsfor FANCL

Search for FANCL

Genome Databases showing FANCL

Other Databases showing FANCL

Specialized Databases showing FANCL

Licensable Technologiesfor FANCL

Servicesfor FANCL

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FANCL

Summaries
for FANCL

Genomic Location
for FANCL

Proteins
for FANCL

Protein Domains/
Families
for FANCL

Gene Function
for FANCL

Pathways & Interactions
for FANCL

Drugs & Compounds
for FANCL

Transcripts
for FANCL

Expression
for FANCL

Orthologs
for FANCL

Paralogs
for FANCL

SNPs/Variants
for FANCL

Disorders & Mutations
for FANCL

Medical News
for FANCL

Publications
for FANCL

Licensable Technologies
for FANCL

Services
for FANCL