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Aliases for FANCG Gene

Aliases for FANCG Gene

  • Fanconi Anemia, Complementation Group G 2 3
  • DNA Repair Protein XRCC9 2 3 4
  • X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 9 2 3
  • XRCC9 3 4
  • X-Ray Repair, Complementing Defective, In Chinese Hamster, 9 3
  • Complementing Defective 2
  • In Chinese Hamster 2
  • X-Ray Repair 2
  • Protein FACG 4
  • FAG 3
  • 9 2

External Ids for FANCG Gene

Previous HGNC Symbols for FANCG Gene

  • XRCC9

Previous GeneCards Identifiers for FANCG Gene

  • GC09M035386
  • GC09M035243
  • GC09M035063
  • GC09M035030

Summaries for FANCG Gene

Entrez Gene Summary for FANCG Gene

  • The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G. [provided by RefSeq, Jul 2008]

GeneCards Summary for FANCG Gene

FANCG (Fanconi Anemia, Complementation Group G) is a Protein Coding gene. Diseases associated with FANCG include fancg-related fanconi anemia and fanconi anemia, complementation group g. Among its related pathways are RB in Cancer and Chks in Checkpoint Regulation. GO annotations related to this gene include signal transducer activity and damaged DNA binding.

UniProtKB/Swiss-Prot for FANCG Gene

  • DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene

Gene Wiki entry for FANCG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FANCG Gene

Genomics for FANCG Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FANCG Gene

Chromosome:
9
Start:
35,073,835 bp from pter
End:
35,080,016 bp from pter
Size:
6,182 bases
Orientation:
Minus strand

Genomic View for FANCG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FANCG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FANCG Gene

Proteins for FANCG Gene

  • Protein details for FANCG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15287-FANCG_HUMAN
    Recommended name:
    Fanconi anemia group G protein
    Protein Accession:
    O15287

    Protein attributes for FANCG Gene

    Size:
    622 amino acids
    Molecular mass:
    68554 Da
    Quaternary structure:
    • Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. The complex is not found in FA patients. In complex with FANCF, FANCA and FANCL, but not with FANCC, nor FANCE, interacts with HES1; this interaction may be essential for the stability and nuclear localization of FA core complex proteins. The complex with FANCC and FANCG may also include EIF2AK2 and HSP70. When phosphorylated at Ser-7, forms a complex with BRCA2, FANCD2 and XRCC3.

neXtProt entry for FANCG Gene

Proteomics data for FANCG Gene at MOPED

Post-translational modifications for FANCG Gene

  • Ubiquitination at Lys 28, Lys 504, and Lys 559
  • Modification sites at PhosphoSitePlus

Other Protein References for FANCG Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FANCG Gene

Domains & Families for FANCG Gene

Gene Families for FANCG Gene

Protein Domains for FANCG Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O15287

UniProtKB/Swiss-Prot:

FANCG_HUMAN :
  • Contains 4 TPR repeats.
Similarity:
  • Contains 4 TPR repeats.
genes like me logo Genes that share domains with FANCG: view

Function for FANCG Gene

Molecular function for FANCG Gene

UniProtKB/Swiss-Prot Function:
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene

Gene Ontology (GO) - Molecular Function for FANCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003684 damaged DNA binding TAS 9806548
GO:0005515 protein binding IPI 10627486
genes like me logo Genes that share ontologies with FANCG: view
genes like me logo Genes that share phenotypes with FANCG: view

Animal Models for FANCG Gene

MGI Knock Outs for FANCG:

Animal Model Products

miRNA for FANCG Gene

miRTarBase miRNAs that target FANCG

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FANCG

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FANCG Gene

Localization for FANCG Gene

Subcellular locations from UniProtKB/Swiss-Prot for FANCG Gene

Nucleus. Cytoplasm. Note=The major form is nuclear. The minor form is cytoplasmic.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FANCG Gene COMPARTMENTS Subcellular localization image for FANCG gene
Compartment Confidence
mitochondrion 5
nucleus 5
plasma membrane 4
cytosol 2

Gene Ontology (GO) - Cellular Components for FANCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA 17060495
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with FANCG: view

Pathways & Interactions for FANCG Gene

genes like me logo Genes that share pathways with FANCG: view

Pathways by source for FANCG Gene

2 BioSystems pathways for FANCG Gene
2 Reactome pathways for FANCG Gene
1 KEGG pathway for FANCG Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for FANCG Gene

Is activated by:

Gene Ontology (GO) - Biological Process for FANCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000075 cell cycle checkpoint TAS 9256465
GO:0001541 ovarian follicle development IEA --
GO:0006281 DNA repair TAS --
GO:0006974 cellular response to DNA damage stimulus --
GO:0007005 mitochondrion organization IMP 17060495
genes like me logo Genes that share ontologies with FANCG: view

Drugs & Compounds for FANCG Gene

(4) Drugs for FANCG Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Mitomycin Approved Pharma Inhibits DNA synthesis,antibiotic and antitumor agent 0
alanine Nutra 97
leucine Nutra 93

(2) Additional Compounds for FANCG Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
diepoxybutane
H2O2
genes like me logo Genes that share compounds with FANCG: view

Transcripts for FANCG Gene

Unigene Clusters for FANCG Gene

Fanconi anemia, complementation group G:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FANCG

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FANCG Gene

No ASD Table

Relevant External Links for FANCG Gene

GeneLoc Exon Structure for
FANCG
ECgene alternative splicing isoforms for
FANCG

Expression for FANCG Gene

mRNA expression in normal human tissues for FANCG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FANCG Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FANCG Gene



SOURCE GeneReport for Unigene cluster for FANCG Gene Hs.591084

mRNA Expression by UniProt/SwissProt for FANCG Gene

O15287-FANCG_HUMAN
Tissue specificity: Highly expressed in testis and thymus. Found in lymphoblasts
genes like me logo Genes that share expression patterns with FANCG: view

Protein tissue co-expression partners for FANCG Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FANCG Gene

Orthologs for FANCG Gene

This gene was present in the common ancestor of chordates.

Orthologs for FANCG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FANCG 35
  • 85.17 (n)
  • 79.75 (a)
MGC159566 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FANCG 35
  • 85.32 (n)
  • 81.08 (a)
FANCG 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fancg 35
  • 79.42 (n)
  • 73.56 (a)
Fancg 16
Fancg 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FANCG 35
  • 99.52 (n)
  • 99.36 (a)
FANCG 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fancg 35
  • 78.29 (n)
  • 71.36 (a)
oppossum
(Monodelphis domestica)
Mammalia FANCG 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 41 (a)
OneToMany
-- 36
  • 47 (a)
OneToMany
chicken
(Gallus gallus)
Aves FANCG 35
  • 49.83 (n)
  • 38.83 (a)
FANCG 36
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FANCG 36
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fancg 35
  • 48.97 (n)
  • 35.96 (a)
zebrafish
(Danio rerio)
Actinopterygii fancg 35
  • 43.33 (n)
  • 32.03 (a)
fancg 36
  • 28 (a)
OneToOne
Species with no ortholog for FANCG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FANCG Gene

ENSEMBL:
Gene Tree for FANCG (if available)
TreeFam:
Gene Tree for FANCG (if available)

Paralogs for FANCG Gene

No data available for Paralogs for FANCG Gene

Variants for FANCG Gene

Sequence variations from dbSNP and Humsavar for FANCG Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs504082 -- 35,079,364(+) CCATC(G/T)GTTGG intron-variant
rs554098 -- 35,077,444(+) CCTCC(C/T)CGTCT intron-variant
rs584040 -- 35,080,833(+) gcctg(C/T)gatcc upstream-variant-2KB
rs587118 -- 35,074,920(+) AAGTA(C/T)ACATA intron-variant
rs595655 -- 35,081,098(+) aaaaa(A/G)aaaag upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FANCG Gene

Variant ID Type Subtype PubMed ID
nsv893043 CNV Gain 21882294

Variation tolerance for FANCG Gene

Residual Variation Intolerance Score: 88.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.39; 71.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FANCG Gene

HapMap Linkage Disequilibrium report
FANCG
Human Gene Mutation Database (HGMD)
FANCG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FANCG Gene

Disorders for FANCG Gene

MalaCards: The human disease database

(20) MalaCards diseases for FANCG Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
fancg-related fanconi anemia
fanconi anemia, complementation group g
  • fanconi anemia complementation group g
congenital hypoplastic anemia
  • congenital aplastic anemia
fanconi syndrome
  • fanconi-bickel syndrome
fanconi anemia, complementation group a
  • fanconi's anemia
- elite association
Search FANCG in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FANCG_HUMAN
  • Fanconi anemia complementation group G (FANCG) [MIM:614082]: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. {ECO:0000269 PubMed:11093276, ECO:0000269 PubMed:18550849}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for FANCG Gene

Fanconi anemia,autosomal recessive,complementation group G,characterized by progressive bone marrow failure (pancytopenia),often associated with skeletal abnormalities and an increased cancer risk and with spontaneous chromosomal breakage exacerbated by exposure to DNA cross-linking agents

Relevant External Links for FANCG

Genetic Association Database (GAD)
FANCG
Human Genome Epidemiology (HuGE) Navigator
FANCG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FANCG
genes like me logo Genes that share disorders with FANCG: view

Publications for FANCG Gene

  1. The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells. (PMID: 9256465) Liu N. … Thompson L.H. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 23 67
  2. Inter-individual variation in DNA double-strand break repair in human fibroblasts before and after exposure to low doses of ionizing radiation. (PMID: 19896956) Wilson P.F. … Thompson L.H. (Mutat. Res. 2010) 23 67
  3. Identification and characterization of mutations in FANCL gene: a second case of Fanconi anemia belonging to FA-L complementation group. (PMID: 19405097) Ali A.M. … Meetei A.R. (Hum. Mutat. 2009) 23 67
  4. Fanconi anemia complementation group FANCD2 protein serine 331 phosphorylation is important for fanconi anemia pathway function and BRCA2 interaction. (PMID: 19861535) Zhi G. … Kupfer G.M. (Cancer Res. 2009) 23 67
  5. The SH3 domain of alphaII spectrin is a target for the Fanconi anemia protein, FANCG. (PMID: 19102630) Lefferts J.A. … Lambert M.W. (Biochemistry 2009) 23 67

Products for FANCG Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate FANCG
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for FANCG
  • Block miRNA regulation of FANCG using miScript Target Protectors

Sources for FANCG Gene

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