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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FANCG Gene

protein-coding   GIFtS: 63
GCID: GC09M035073

Fanconi Anemia, Complementation Group G


(Previous symbol: XRCC9)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fanconi Anemia, Complementation Group G1 2     In Chinese Hamster1
XRCC91 2 3 5     X-Ray Repair1
DNA Repair Protein XRCC91 2 3     FAG2
X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 91 2     Fanconi Anemia Group G Protein2
91     X-Ray Repair, Complementing Defective, In Chinese Hamster, 92
Complementing Defective1     Protein FACG3

External Ids:    HGNC: 35881   Entrez Gene: 21892   Ensembl: ENSG000002218297   OMIM: 6029565   UniProtKB: O152873   

Export aliases for FANCG gene to outside databases

Previous GC identifers: GC09M035386 GC09M035243 GC09M035063 GC09M035030


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FANCG Gene:
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called
BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called
PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous
recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents,
increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group
do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This
gene encodes the protein for complementation group G. (provided by RefSeq, Jul 2008)

GeneCards Summary for FANCG Gene: 
FANCG (Fanconi anemia, complementation group G) is a protein-coding gene. Diseases associated with FANCG include fancg-related fanconi anemia, and fanconi anemia, complementation group a, and among its related super-pathways are Fanconi's Anaemia Pathway and Nucleotide Excision Repair. GO annotations related to this gene include damaged DNA binding and protein binding.

UniProtKB/Swiss-Prot: FANCG_HUMAN, O15287
Function: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May
be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.
Candidate tumor suppressor gene

Gene Wiki entry for FANCG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008413.18  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FANCG gene promoter:
         Pax-5   RREB-1   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   GATA-1   CREB   deltaCREB   STAT3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FANCG promoter sequence
   Search SABiosciences Chromatin IP Primers for FANCG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FANCG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13

FANCG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FANCG gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M035073:  view genomic region     (about GC identifiers)

Start:
35,073,832 bp from pter      End:
35,080,013 bp from pter
Size:
6,182 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FANCG_HUMAN, O15287 (See protein sequence)
Recommended Name: Fanconi anemia group G protein  
Size: 622 amino acids; 68554 Da
Subunit: Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9
and FANCM. The complex is not found in FA patients. In complex with FANCF, FANCA and FANCL, but not with FANCC,
nor FANCE, interacts with HES1; this interaction may be essential for the stability and nuclear localization of
FA core complex proteins. The complex with FANCC and FANCG may also include EIF2AK2 and HSP70. When
phosphorylated at Ser-7, forms a complex with BRCA2, FANCD2 and XRCC3
Subcellular location: Nucleus. Cytoplasm. Note=The major form is nuclear. The minor form is cytoplasmic

Explore the universe of human proteins at neXtProt for FANCG: NX_O15287

Explore proteomics data for FANCG at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15287

  • FANCG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FANCG Protein Expression
    REFSEQ proteins: NP_004620.1  
    ENSEMBL proteins: 
     ENSP00000412793   ENSP00000367910   ENSP00000409607  
    Reactome Protein details: O15287
    Human Recombinant Protein Products for FANCG: 
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    Cloud-Clone Corp. Proteins for FANCG 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005739mitochondrion IDA17060495
    GO:0043240Fanconi anaemia nuclear complex IDA--

    FANCG for ontologies           About GeneDecksing



    FANCG Antibody Products: 
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    ThermoFisher Antibody for FANCG
    LSBio Antibodies in human, mouse, rat for FANCG 

    Assay Products for FANCG: 
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    Cloud-Clone Corp. CLIAs for FANCG


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FANC: Fanconi anemia, complementation groups

    3 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR001440 TPR-1
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry O15287

    ProtoNet protein and cluster: O15287

    UniProtKB/Swiss-Prot: FANCG_HUMAN, O15287
    Similarity: Contains 4 TPR repeats


    FANCG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FANCG_HUMAN, O15287
    Function: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May
    be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.
    Candidate tumor suppressor gene

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003684damaged DNA binding TAS9806548
    GO:0004871signal transducer activity ----
    GO:0005515protein binding IPI10627486
         
    FANCG for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Fancg):
     cellular  endocrine/exocrine gland  no phenotypic analysis  reproductive system 

    FANCG for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FANCG: Fancgtm1Faw Fancgtm1Brs Fancgtm1Ada

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FANCG 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FANCG 
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    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate FANCG:
    hsa-miR-4267
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FANCG About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Fanconi Anemia pathway
    Fanconi's Anaemia Pathway0.43
    BARD1 signaling events0.41
    Fanconi Anemia pathway0.43
    2Nucleotide Excision Repair
    DNA Repair0.46
    3Chks in Checkpoint Regulation
    DNA Repair Mechanisms0.32
    4Meiosis
    Meiosis
    5BRCA1 Pathway
    BRCA1 Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for FANCG
        Meiosis

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FANCG
        Fanconi's Anaemia Pathway
    BRCA1 Pathway
    DNA Repair Mechanisms

    1 BioSystems Pathway for FANCG
        BARD1 signaling events


    2        Reactome Pathways for FANCG
        DNA Repair
    Fanconi Anemia pathway


    1         Kegg Pathway  (Kegg details for FANCG):
        Fanconi anemia pathway


    FANCG for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FANCG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/65 Interacting proteins for FANCG (O152871, 2, 3 ENSP000003679104) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FANCAO153601, 2, 3, ENSP000003739524EBI-81610,EBI-81570 MINT-4789325 MINT-19441 MINT-19440 MINT-4789189 MINT-68475 MINT-19452 MINT-4789226 MINT-19444 MINT-19447 I2D: score=8 STRING: ENSP00000373952
    FANCBQ8NB912, 3, ENSP000003268194MINT-4789189 MINT-4789226 I2D: score=1 STRING: ENSP00000326819
    SAMD3Q8N6K72, 3MINT-67343 I2D: score=4 
    SPTAN1Q138132, 3, ENSP000003618244MINT-7231728 MINT-7231752 MINT-7231786 MINT-7231852 I2D: score=2 STRING: ENSP00000361824
    FANCFQ9NPI81, 2, 3, ENSP000003308754EBI-81610,EBI-81589 MINT-19449 MINT-19448 I2D: score=5 STRING: ENSP00000330875
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS9256465
    GO:0000160phosphorelay signal transduction system ----
    GO:0001541ovarian follicle development IEA--
    GO:0006281DNA repair TAS--
    GO:0006974response to DNA damage stimulus ----

    FANCG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FANCG for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FANCG

    6 Novoseek inferred chemical compound relationships for FANCG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mitomycin c 79.7 13 12637330 (2), 10567393 (2), 11756225 (2), 12915460 (1) (see all 7)
    diepoxybutane 67.7 2 12637330 (1)
    cisplatin 26.7 1 9256465 (1)
    leucine 14.5 2 11050007 (1), 11093276 (1)
    alanine 1.72 1 10567393 (1)
    h2o2 0 1 15138265 (1)

    Search CenterWatch for drugs/clinical trials and news about FANCG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FANCG gene: 
    NM_004629.1  

    Unigene Cluster for FANCG:

    Fanconi anemia, complementation group G
    Hs.591084  [show with all ESTs]
    Unigene Representative Sequence: AJ007669
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000425676 ENST00000378643(uc011lot.1 uc003zwb.1 uc010mkj.1)
    ENST00000476212 ENST00000481254 ENST00000474894 ENST00000448890 ENST00000461149
    ENST00000462124
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate FANCG:
    hsa-miR-4267
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    Inhib. RNA
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    Additional mRNA sequence: 

    AJ007669.1 AK293427.1 AK311348.1 AK312987.1 BC000032.2 BC011623.2 BT009813.1 U70310.1 

    16 DOTS entries:

    DT.115886  DT.100781895  DT.100781893  DT.95280820  DT.100781892  DT.121145912  DT.91969485  DT.95280823 
    DT.121145915  DT.121145920  DT.95280822  DT.100781883  DT.102838808  DT.95280830  DT.121145935  DT.95280831 

    24/197 AceView cDNA sequences (see all 197):

    BC000032 AI160173 BU632413 AL701956 AW955161 Z41736 BM551902 CB216191 
    BM716105 AA426567 BE513377 BM666874 BU192683 AI689863 BQ021266 BT009813 
    BM051787 CR592637 BQ898789 BC011623 T33509 BQ438144 BM695098 AJ007669 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FANCG expression in normal human tissues (normalized intensities)      FANCG embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGATGCTCT
    FANCG Expression
    About this image


    FANCG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Uterus (Reproductive System)
             CERVIX   
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Testis (Reproductive System)
     
     Lymph (Hematopoietic System)

    See FANCG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FANCG

    SOURCE GeneReport for Unigene cluster: Hs.591084

    UniProtKB/Swiss-Prot: FANCG_HUMAN, O15287
    Tissue specificity: Highly expressed in testis and thymus. Found in lymphoblasts

        SABiosciences Expression via Pathway-Focused PCR Array including FANCG: 
              DNA Damage Signaling Pathway in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FANCG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FANCG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FANCG gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fancg1 , 5 Fanconi anemia, complementation group G1, 5 79.42(n)1
    73.56(a)1
      4 (22.97 cM)5
    605341  NM_053081.21  NP_444311.11 
     430023435 
    chicken
    (Gallus gallus)
    Aves FANCG1 Fanconi anemia, complementation group G 50.57(n)
    39(a)
      378893  NM_204378.1  NP_989709.1 
    lizard
    (Anolis carolinensis)
    Reptilia FANCG6
    Fanconi anemia, complementation group G
    35(a)
    1 ↔ 1
    GL343804.1(85385-97350)
    zebrafish
    (Danio rerio)
    Actinopterygii fancg1 Fanconi anemia, complementation group G 43.87(n)
    31.94(a)
      402936  NM_205639.1  NP_991202.1 


    ENSEMBL Gene Tree for FANCG (if available)
    TreeFam Gene Tree for FANCG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/211 SNPs in FANCG are shown (see all 211)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358644
    A colorectal cancer sample4--see VAR_0358642 A T mis40--------
    VAR_0174954
    Fanconi anemia complementation group G (FANCG)4--see VAR_0174952 L P mis40--------
    VAR_0211084
    ----see VAR_0211082 S F mis40--------
    rs178825371,2
    F--35046147(-) TAGGG-/TAGGG 
            
    ATAGG
    1 -- int11Minor allele frequency- TAGGG:0.01NS 170
    rs1477296861,2
    --35046337(+) TGCCTA/GTCCAA 1 -- int10--------
    rs178855061,2
    C,F--35046506(-) TCCTCC/TTTCCT 1 -- int14Minor allele frequency- T:0.01NS CSA NA EU 887
    rs1405347651,2
    C,F--35046576(+) CAAGGC/TCAGGT 2 T A mis11Minor allele frequency- T:0.00NA 4552
    rs2010995601,2
    C--35046590(+) CAAGAC/TGGTCA 2 H R mis10--------
    rs2009262491,2
    --35046591(+) AAGACA/GGTCAG 2 R C mis10--------
    rs2000744321,2
    --35046596(+) GGTCAC/GCACTC 2 A G mis10--------

    HapMap Linkage Disequilibrium report for FANCG (35073832 - 35080013 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FANCG:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv893043CNV Gain21882294


    Human Gene Mutation Database (HGMD): FANCG

    Locus Specific Mutation Databases (LSDB): FANCG
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602956    OMIM disorders: --

    UniProtKB/Swiss-Prot: FANCG_HUMAN, O15287
  • Fanconi anemia complementation group G (FANCG) [MIM:614082]: A disorder affecting all bone marrow
    elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb
    malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the
    cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased
    chromosome breakage) and defective DNA repair. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 20/26 diseases for FANCG (see all 26):    About MalaCards
    fancg-related fanconi anemia    fanconi anemia, complementation group a    fanconi anemia, complementation group b    anemia
    fanconi's anemia    mutagen sensitivity    hereditary pancreatitis    pancreatic cancer
    pancytopenia    leukopenia    sporadic breast cancer    familial breast cancer
    bloom syndrome    breast cancer susceptibility    aplastic anemia    oral squamous cell carcinoma
    breast cancer    acute lymphoblastic leukemia    pancreatitis    lymphoblastic leukemia

    1 disease from the University of Copenhagen DISEASES database for FANCG:
    Aplastic anemia

    FANCG for disorders           About GeneDecksing

    10/12 Novoseek inferred disease relationships for FANCG gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fanconis anemia 96.8 19 12552564 (2), 11050007 (1), 15299017 (1), 19102630 (1) (see all 17)
    cancer 47.5 2 12351379 (1), 19861535 (1)
    anemia 43.5 5 16643430 (1), 12915460 (1), 11093276 (1), 12001267 (1)
    t-all 36.1 2 10994546 (1)
    pancreatic cancer 33.2 11 14726700 (5), 15277238 (1), 15107617 (1), 12750283 (1) (see all 5)
    hnscc 32.8 2 17409780 (1), 16466850 (1)
    chromosomal aberrations 20.7 2 9256465 (1), 17097336 (1)
    somatic mutations 19.1 2 14726700 (1), 12750283 (1)
    carcinoma squamous cell 15.2 1 16982972 (1)
    breast cancer 13.9 2 14695169 (1)

    Genatlas disease: FANCG
    Fanconi anemia,autosomal recessive,complementation group G,characterized by progressive bone marrow failure
    (pancytopenia),often associated with skeletal abnormalities and an increased cancer risk and with spontaneous
    chromosomal breakage exacerbated by exposure to DNA cross-linking agents

    GeneTests: FANCG
    GeneReviews: FANCG
    Genetic Association Database (GAD): FANCG
    Human Genome Epidemiology (HuGE) Navigator: FANCG (15 documents)

    Export disorders for FANCG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FANCG gene, integrated from 9 sources (see all 152):
    (articles sorted by number of sources associating them with FANCG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells. (PubMed id 9256465)1, 2, 3, 9 Liu N.... Thompson L.H. (1997)
    2. FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. (PubMed id 18212739)1, 2, 9 Wilson J.B....Jones N.J. (2008)
    3. Spectrum of mutations in the Fanconi anaemia group G gene, FANCG/XRCC9. (PubMed id 11093276)1, 2, 9 Demuth I.... Digweed M. (2000)
    4. The Fanconi anemia proteins functionally interact with the protein kinase regulated by RNA (PKR). (PubMed id 15299030)1, 2, 9 Zhang X....Pang Q. (2004)
    5. Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex. (PubMed id 10373536)1, 2, 9 Garcia-Higuera I.... D'Andrea A.D. (1999)
    6. A ubiquitin-binding protein, FAAP20, links RNF8-mediat ed ubiquitination to the Fanconi anemia DNA repair network. (PubMed id 22705371)1, 2 Yan Z....Wang W. (2012)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. Comprehensive screen of genetic variation in DNA repa ir pathway genes and postmenopausal breast cancer risk. (PubMed id 20496165)1, 4 Monsees G.M....Han J. (2010)
    9. Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project. (PubMed id 19339270)1, 4 Canova C....Brennan P. (2009)
    10. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PubMed id 19237606)1, 4 Michiels S....Benhamou S. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2189 HGNC: 3588 AceView: FANCG Ensembl:ENSG00000221829 euGenes: HUgn2189
    ECgene: FANCG Kegg: 2189 H-InvDB: FANCG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FANCG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FANCG Genetics and Cytogenetics in Oncology and Haematology
    Fanconi Anemia Mutation Databasehttp://www.rockefeller.edu/fanconi/mutate/jumpg.html
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/FANCG
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fancg/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FANCG gene:
    Search GeneIP for patents involving FANCG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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