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FANCG Gene

protein-coding   GIFtS: 65
GCID: GC09M035073

Fanconi Anemia, Complementation Group G


(Previous symbol: XRCC9)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fanconi Anemia, Complementation Group G1 2     In Chinese Hamster1
XRCC91 2 3 5     X-Ray Repair1
DNA Repair Protein XRCC91 2 3     FAG2
X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 91 2     Fanconi Anemia Group G Protein2
91     X-Ray Repair, Complementing Defective, In Chinese Hamster, 92
Complementing Defective1     Protein FACG3

External Ids:    HGNC: 35881   Entrez Gene: 21892   Ensembl: ENSG000002218297   OMIM: 6029565   UniProtKB: O152873   

Export aliases for FANCG gene to outside databases

Previous GC identifers: GC09M035386 GC09M035243 GC09M035063 GC09M035030


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FANCG Gene:
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called
BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called
PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous
recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents,
increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group
do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This
gene encodes the protein for complementation group G. (provided by RefSeq, Jul 2008)

GeneCards Summary for FANCG Gene:
FANCG (Fanconi anemia, complementation group G) is a protein-coding gene. Diseases associated with FANCG include fanconi anemia, complementation group g, and fancg-related fanconi anemia. GO annotations related to this gene include damaged DNA binding.

UniProtKB/Swiss-Prot: FANCG_HUMAN, O15287
Function: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May
be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.
Candidate tumor suppressor gene

Gene Wiki entry for FANCG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008413.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the FANCG gene promoter:
         Pax-5   RREB-1   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   GATA-1   CREB   deltaCREB   STAT3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FANCG promoter sequence
   Search Chromatin IP Primers for FANCG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FANCG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13

FANCG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FANCG gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M035073:  view genomic region     (about GC identifiers)

Start:
35,073,832 bp from pter      End:
35,080,013 bp from pter
Size:
6,182 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FANCG_HUMAN, O15287 (See protein sequence)
Recommended Name: Fanconi anemia group G protein  
Size: 622 amino acids; 68554 Da
Subunit: Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9
and FANCM. The complex is not found in FA patients. In complex with FANCF, FANCA and FANCL, but not with FANCC,
nor FANCE, interacts with HES1; this interaction may be essential for the stability and nuclear localization of
FA core complex proteins. The complex with FANCC and FANCG may also include EIF2AK2 and HSP70. When
phosphorylated at Ser-7, forms a complex with BRCA2, FANCD2 and XRCC3

Explore the universe of human proteins at neXtProt for FANCG: NX_O15287

Explore proteomics data for FANCG at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys28, Lys491, Lys504, Lys559
  • Modification sites at PhosphoSitePlus

  • See FANCG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004620.1  
    ENSEMBL proteins: 
     ENSP00000412793   ENSP00000367910   ENSP00000409607  
    Reactome Protein details: O15287

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    Cloud-Clone Corp. CLIAs for FANCG


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FANC: Fanconi anemia, complementation groups

    3 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR001440 TPR_1
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry O15287

    ProtoNet protein and cluster: O15287

    UniProtKB/Swiss-Prot: FANCG_HUMAN, O15287
    Similarity: Contains 4 TPR repeats


    FANCG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FANCG_HUMAN, O15287
    Function: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May
    be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.
    Candidate tumor suppressor gene

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003684damaged DNA binding TAS9806548
    GO:0004871signal transducer activity ----
    GO:0005515protein binding IPI10627486
         
    FANCG for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Fancg):
     cellular  endocrine/exocrine gland  no phenotypic analysis  reproductive system 

    FANCG for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FANCG: Fancgtm1Faw Fancgtm1Brs Fancgtm1Ada

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FANCG
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FANCG

    miRNA
    Products:
        
    miRTarBase miRNAs that target FANCG:
    hsa-mir-23a-3p (MIRT006898), hsa-mir-193b-3p (MIRT016405), hsa-mir-744-5p (MIRT037687)

    Block miRNA regulation of human, mouse, rat FANCG using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate FANCG:
    hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidFANCG 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat FANCG

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: FANCG (NM_004629)
    Sino Biological Human cDNA Clone for FANCG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FANCG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FANCG

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FANCG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FANCG_HUMAN, O15287: Nucleus. Cytoplasm. Note=The major form is nuclear. The minor form is cytoplasmic
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    cytosol1
    extracellular1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA17060495
    GO:0005886plasma membrane IDA--

    FANCG for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FANCG About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1BRCA1 Pathway
    BRCA1 Pathway
    Fanconi's Anaemia Pathway0.00
    2DNA Repair
    DNA Repair0.45
    3Chks in Checkpoint Regulation
    DNA Repair Mechanisms0.32
    4RB in Cancer
    RB in Cancer
    5Meiosis (EMD)
    Meiosis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FANCG
        Fanconi's Anaemia Pathway
    BRCA1 Pathway
    DNA Repair Mechanisms

    2 BioSystems Pathways for FANCG
        RB in Cancer
    BARD1 signaling events


    1 Reactome Pathway for FANCG
        Fanconi Anemia pathway


    1 Kegg Pathway  (Kegg details for FANCG):
        Fanconi anemia pathway


    FANCG for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including FANCG: 
              DNA Damage Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FANCG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FANCG (O152871, 2, 3 ENSP000003679104) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FANCAO153601, 2, 3, ENSP000003739524EBI-81610,EBI-81570 MINT-4789325 MINT-19441 MINT-19440 MINT-68475 MINT-4789189 MINT-19452 MINT-4789226 MINT-19444 MINT-19447 I2D: score=8 STRING: ENSP00000373952
    FANCBQ8NB912, 3, ENSP000003268194MINT-4789189 MINT-4789226 I2D: score=1 STRING: ENSP00000326819
    SAMD3Q8N6K72, 3MINT-67343 I2D: score=4 
    SPTAN1Q138131, 2, 3, ENSP000003618244EBI-81610,EBI-351450 MINT-7231728 MINT-7231752 MINT-7231786 MINT-7231852 I2D: score=2 STRING: ENSP00000361824
    FANCFQ9NPI81, 2, 3, ENSP000003308754EBI-81610,EBI-81589 MINT-19449 MINT-19448 I2D: score=5 STRING: ENSP00000330875
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS9256465
    GO:0000160phosphorelay signal transduction system ----
    GO:0001541ovarian follicle development IEA--
    GO:0006281DNA repair TAS--
    GO:0006974cellular response to DNA damage stimulus ----

    FANCG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FANCG

    6 Novoseek inferred chemical compound relationships for FANCG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mitomycin c 79.7 13 12637330 (2), 10567393 (2), 11756225 (2), 12915460 (1) (see all 7)
    diepoxybutane 67.7 2 12637330 (1)
    cisplatin 26.7 1 9256465 (1)
    leucine 14.5 2 11050007 (1), 11093276 (1)
    alanine 1.72 1 10567393 (1)
    h2o2 0 1 15138265 (1)



    FANCG for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FANCG gene: 
    NM_004629.1  

    Unigene Cluster for FANCG:

    Fanconi anemia, complementation group G
    Hs.591084  [show with all ESTs]
    Unigene Representative Sequence: AJ007669
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000425676 ENST00000378643(uc011lot.1 uc003zwb.1 uc010mkj.1)
    ENST00000476212 ENST00000481254 ENST00000474894 ENST00000448890 ENST00000461149
    ENST00000462124
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate FANCG:
    hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidFANCG 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat FANCG

    Additional mRNA sequence: 

    AJ007669.1 AK293427.1 AK311348.1 AK312987.1 BC000032.2 BC011623.2 BT009813.1 U70310.1 

    16 DOTS entries:

    DT.115886  DT.100781895  DT.100781893  DT.95280820  DT.100781892  DT.121145912  DT.91969485  DT.95280823 
    DT.121145915  DT.121145920  DT.95280822  DT.100781883  DT.102838808  DT.95280830  DT.121145935  DT.95280831 

    Selected AceView cDNA sequences (see all 197):

    T35916 AL556166 BM511575 AI689863 AW954430 BU632413 AA233751 BQ881362 
    Z41736 AA814381 AJ007669 BU192683 BM666874 BM833705 BI768659 BE513377 
    BP364172 BQ898789 CB216191 BM915600 AW955161 NM_004629 AA428979 CA390704 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FANCG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGATGCTCT
    FANCG Expression
    About this image


    FANCG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Testis (Reproductive System)
     
     Lymph (Hematopoietic System)
    FANCG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FANCG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591084

    UniProtKB/Swiss-Prot: FANCG_HUMAN, O15287
    Tissue specificity: Highly expressed in testis and thymus. Found in lymphoblasts

        Pathway & Disease-focused RT2 Profiler PCR Array including FANCG: 
              DNA Damage Signaling Pathway in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat FANCG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FANCG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FANCG gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fancg1 , 5 Fanconi anemia, complementation group G1, 5 79.42(n)1
    73.56(a)1
      4 (22.97 cM)5
    605341  NM_053081.21  NP_444311.11 
     430023435 
    chicken
    (Gallus gallus)
    Aves FANCG1 Fanconi anemia, complementation group G 49.83(n)
    38.83(a)
      378893  NM_204378.1  NP_989709.1 
    lizard
    (Anolis carolinensis)
    Reptilia FANCG6
    Fanconi anemia, complementation group G
    36(a)
    1 ↔ 1
    GL343804.1(85385-97350)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fancg1 Fanconi anemia, complementation group G 48.97(n)
    35.96(a)
      100145235  NM_001126721.1  NP_001120193.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fancg1 Fanconi anemia, complementation group G 43.33(n)
    32.03(a)
      402936  NM_205639.1  NP_991202.1 


    ENSEMBL Gene Tree for FANCG (if available)
    TreeFam Gene Tree for FANCG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FANCG (see all 211)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358644
    A colorectal cancer sample4--see VAR_0358642 A T mis40--------
    VAR_0174954
    Fanconi anemia complementation group G (FANCG)4--see VAR_0174952 L P mis40--------
    rs178825371,2
    F--35046147(-) TAGGG-/TAGGG 
            
    ATAGG
    1 -- int11Minor allele frequency- TAGGG:0.01NS 170
    rs1477296861,2
    --35046337(+) TGCCTA/GTCCAA 1 -- int10--------
    rs178855061,2
    C,F--35046506(-) TCCTCC/TTTCCT 1 -- int14Minor allele frequency- T:0.01NS CSA NA EU 887
    rs1405347651,2
    C,F--35046576(+) CAAGGC/TCAGGT 2 T A mis11Minor allele frequency- T:0.00NA 4552
    rs2010995601,2
    C--35046590(+) CAAGAC/TGGTCA 2 H R mis10--------
    rs2009262491,2
    --35046591(+) AAGACA/GGTCAG 2 R C mis10--------
    rs2000744321,2
    --35046596(+) GGTCAC/GCACTC 2 A G mis10--------
    rs2021148131,2
    --35046606(+) CAACCA/TGAGGG 2 R W mis10--------

    HapMap Linkage Disequilibrium report for FANCG (35073832 - 35080013 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FANCG:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv893043CNV Gain21882294

    Human Gene Mutation Database (HGMD): FANCG
    Locus Specific Mutation Databases (LSDB): FANCG

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602956   
    OMIM disorders: 614082  
    UniProtKB/Swiss-Prot: FANCG_HUMAN, O15287
  • Fanconi anemia complementation group G (FANCG) [MIM:614082]: A disorder affecting all bone marrow
    elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb
    malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the
    cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased
    chromosome breakage) and defective DNA repair. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • Selected diseases for FANCG (see all 32):    
    About MalaCards
    fanconi anemia, complementation group g    fancg-related fanconi anemia    fanconi anemia, complementation group a    fanconi anemia, complementation group f
    fanconi anemia, complementation group e    fanconi anemia, complementation group b    mutagen sensitivity    fanconi anemia, complementation group m
    fanconi's anemia    hereditary pancreatitis    fanconi anemia, complementation group c    pancytopenia
    sporadic breast cancer    familial breast cancer    leukopenia    bloom syndrome
    pancreatic cancer    aplastic anemia    oral squamous cell carcinoma    breast cancer

    1 disease from the University of Copenhagen DISEASES database for FANCG:
    Aplastic anemia

    FANCG for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for FANCG gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fanconis anemia 96.8 19 12552564 (2), 11050007 (1), 15299017 (1), 19102630 (1) (see all 17)
    cancer 47.5 2 12351379 (1), 19861535 (1)
    anemia 43.5 5 16643430 (1), 12915460 (1), 11093276 (1), 12001267 (1)
    t-all 36.1 2 10994546 (1)
    pancreatic cancer 33.2 11 14726700 (5), 15277238 (1), 15107617 (1), 12750283 (1) (see all 5)
    hnscc 32.8 2 17409780 (1), 16466850 (1)
    chromosomal aberrations 20.7 2 9256465 (1), 17097336 (1)
    somatic mutations 19.1 2 14726700 (1), 12750283 (1)
    carcinoma squamous cell 15.2 1 16982972 (1)
    breast cancer 13.9 2 14695169 (1)

    Genatlas disease: FANCG
    Fanconi anemia,autosomal recessive,complementation group G,characterized by progressive bone marrow failure
    (pancytopenia),often associated with skeletal abnormalities and an increased cancer risk and with spontaneous
    chromosomal breakage exacerbated by exposure to DNA cross-linking agents

    GeneTests: FANCG
    GeneReviews: FANCG
    Genetic Association Database (GAD): FANCG
    Human Genome Epidemiology (HuGE) Navigator: FANCG (15 documents)

    Export disorders for FANCG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FANCG gene, integrated from 10 sources (see all 153):
    (articles sorted by number of sources associating them with FANCG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells. (PubMed id 9256465)1, 2, 3, 9 Liu N.... Thompson L.H. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    2. FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3. (PubMed id 18212739)1, 2, 9 Wilson J.B....Jones N.J. (Oncogene 2008)
    3. Spectrum of mutations in the Fanconi anaemia group G gene, FANCG/XRCC9. (PubMed id 11093276)1, 2, 9 Demuth I.... Digweed M. (Eur. J. Hum. Genet. 2000)
    4. The Fanconi anemia proteins functionally interact with the protein kinase regulated by RNA (PKR). (PubMed id 15299030)1, 2, 9 Zhang X.... Pang Q. (J. Biol. Chem. 2004)
    5. Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex. (PubMed id 10373536)1, 2, 9 Garcia-Higuera I.... D'Andrea A.D. (Mol. Cell. Biol. 1999)
    6. A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network. (PubMed id 22705371)1, 2 Yan Z.... Wang W. (Mol. Cell 2012)
    7. Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. (PubMed id 20496165)1, 4 Monsees G.M....Han J. (Breast Cancer Res. Treat. 2011)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project. (PubMed id 19339270)1, 4 Canova C....Brennan P. (Cancer Res. 2009)
    10. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PubMed id 19237606)1, 4 Michiels S....Benhamou S. (Carcinogenesis 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2189 HGNC: 3588 AceView: FANCG Ensembl:ENSG00000221829 euGenes: HUgn2189
    ECgene: FANCG Kegg: 2189 H-InvDB: FANCG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FANCG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FANCG Genetics and Cytogenetics in Oncology and Haematology
    Fanconi Anemia Mutation Databasehttp://www.rockefeller.edu/fanconi/mutate/jumpg.html
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=FANCG[genesymbol]
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fancg/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FANCG gene:
    Search GeneIP for patents involving FANCG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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