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Aliases & Descriptions for FANCF
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FAF 1, 2 | | MGC126856 2 |
| | | Descriptions |
|---|
| Fanconi anemia, complementation group F 2 | | Protein FACF 3 |
|
| | Search outside databases for aliases for FANCF genePrevious GC identifers: GC11M024061 GC11M023445 GC11M022683 GC11M022608 |
Summaries for FANCF(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for FANCF: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group F. [provided by RefSeq] UniProtKB/Swiss-Prot: FANCF_HUMAN, Q9NPI8Function: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity)Gene Wiki entry for FANCF |
Genomic Location for FANCF
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the FANCF gene 
Entrez Gene cytogenetic band: 11p15 Ensembl cytogenetic band: 11p14.3 HGNC cytogenetic band: 11p15FANCF Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M022600:
(about GC identifiers)
Start:
|
22,600,655 bp from pter |
End:
|
22,603,963 bp from pter |
Size:
|
3,309 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000011.8 NT_009237.17
| Proteins for FANCF
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: FANCF_HUMAN, Q9NPI8 (See
protein sequence)Recommended Name: Fanconi anemia group F protein Size: 374 amino acids; 42254 Da
Subunit: Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. The complex is not found in FA patients
Subcellular location: Nucleus
PDB structures from and Proteopedia :2IQC (3D)
 
Secondary accessions: Q52LM0REFSEQ proteins: NP_073562.1
ENSEMBL proteins: ENSP00000330875
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for FANCF: Assays for FANCF: | Protein
Domains/ Families for FANCF(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9NPI8 | Gene Function for FANCF
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_022725
Applied Biosystems Silencer® siRNAs for FANCF
Sigma-Aldrich siRNA for FANCF  Sigma-Aldrich shRNA Panels and shRNA for FANCF  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_022725                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_022725                                  untagged cDNA clone in CMV expression vector: NM_022725 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_022725
UniProtKB/Swiss-Prot: FANCF_HUMAN, Q9NPI8Function: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity)Genatlas biochemistry entry for FANCF:putative RNA binding protein,highly homolog to the prokaryotic RNA-binding protein ROM,intronless2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for FANCF
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for FANCF (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for FANCF 
5/29 Interacting proteins for FANCF (Q9NPI81, 2 ENSP000003308753) via UniProtKB, MINT, and/or STRING (see all 29
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for FANCF(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for FANCF
|
Transcripts for FANCF(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_022725
Sigma-Aldrich siRNA for FANCF  Sigma-Aldrich shRNA Panels and shRNA for FANCF  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_022725 REFSEQ mRNAs for FANCF gene: NM_022725.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_022725               OriGene GFP tagged cDNA clone in CMV expression vector: NM_022725                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_022725                                  untagged cDNA clone in CMV expression vector: NM_022725  Additional cDNA sequence: AF181994.1 AF181995.1 AK001716.2 AK023153.1 AK223277.1 BC017792.1 BC035346.1 BC047028.1 BC063038.1 BC093867.1 BC101807.1 BX640996.1 CR603993.1 7 DOTS entries: DT.408917 DT.120707290 DT.75192878 DT.95164586 DT.95164585 DT.100661874 DT.99946085
highest scoring ESTs for FANCF:AI766126 AA173346 AA347083 AA973733 AF181994 AF181995 AI695012 AI739046 AK001716 AK023153 Unigene Cluster for FANCF: Fanconi anemia, complementation group F Hs.713574 [show with all ESTs]Unigene Representative Sequence: NM_022725
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000327470
|
Expression for FANCF
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| FANCF expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for FANCF
1 / 2 / 3 7 probe-sets matching FANCF gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AAGGCCATCT
SOURCE GeneReport for Unigene cluster: Hs.713574
|
Orthologs for FANCF
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for FANCF gene from 5/6 species (see all 6
)
About this table Species with no ortholog for FANCF
ENSEMBL Gene Tree for FANCF | Paralogs for FANCF(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for FANCF(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for FANCF (up to first 250kb)
|
Disorders & Mutations for FANCF
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 603467 UniProtKB/Swiss-Prot: FANCF_HUMAN, Q9NPI8
Defects in FANCF are a cause of Fanconi anemia (FA) [MIM:227650]. FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair9 Novoseek disease relationships for FANCF gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| fanconis anemia |
95.32 |
6 |
16466850 (1), 12239156 (1), 12351379 (1), 15262960 (1) (see all 6) |
| hnscc |
55.01 |
6 |
16466850 (3), 14647419 (2), 17409780 (1) |
| anemia |
43.24 |
3 |
12001267 (1), 10615118 (1), 14617007 (1) |
| cancer |
39.64 |
2 |
18607065 (1), 12351379 (1) |
| leukemia |
23.97 |
2 |
16803569 (2) |
| ovarian cancer |
22.68 |
11 |
16418574 (7), 14647419 (1) |
| breast cancer |
18.39 |
4 |
17932744 (2), 14695169 (1) |
| primary tumor |
9.27 |
1 |
14647419 (1) |
| tumors |
5.54 |
6 |
19236379 (1), 16418574 (1), 18000367 (1), 17932744 (1) |
About this table
GeneTests: FANCF Fanconi Anemia Human Gene Mutation Database: FANCF Human Genome Epidemiology Navigator: FANCF (4 documents)
|
Medical News for FANCF(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for FANCF (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/60 PubMed articles for FANCF gene (see all 60
):- Structural determinants of human FANCF protein that function in the assembly of a DNA damage signaling complex. (PubMed id 17082180)1, 3, 4 Kowal P.... Ellenberger T. (2007)
- The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG. (PubMed id 11063725)1, 3, 4 de Winter J.P.... Joenje H. (2000)
- The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM. (PubMed id 10615118)1, 3, 4 de Winter J.P.... Joenje H. (2000)
- A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. (PubMed id 16116422)3, 4 Meetei A.R....Wang W. (2005)
- X-linked inheritance of Fanconi anemia complementation group B. (PubMed id 15502827)3, 4 Meetei A.R....Joenje H. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome. (PubMed id 12724401)3, 4 Meetei A.R.... Wang W. (2003)
- Evidence for at least eight Fanconi anemia genes. (PubMed id 9382107)2, 3 Joenje H....Arwert F. (1997)
- Promoter hypermethylation of FANCF plays an important role in the occurrence of ovarian cancer through disrupting Fanconi anemia-BRCA pathway. (PubMed id 16418574)1, 3 Wang Z....Wang H. (2006)
|
Search for FANCF
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing FANCF
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing FANCF
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FANCF(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| ATLAS Chromosomes in Cancer entry for FANCF | Genetics and Cytogenetics in Oncology and Haematology | | Fanconi Anemia Mutation Database | http://www.rockefeller.edu/fanconi/mutate/jumpf.html | | GeneReviews | http://www.genetests.org/query?gene=FANCF | | NIEHS-SNPs | http://egp.gs.washington.edu/data/fancf/ |
|
| | | About This Section
| --
| Services for FANCF(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for FANCF:

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Incremental update: 13 Oct 2009
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