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FANCF Gene

protein-coding   GIFtS: 59
GCID: GC11M022600

Fanconi Anemia, Complementation Group F

  See FANCF-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fanconi Anemia, Complementation Group F1 2
FAF2
Fanconi Anemia Group F Protein2
Protein FACF3

External Ids:    HGNC: 35871   Entrez Gene: 21882   Ensembl: ENSG000001831617   OMIM: 6138975   UniProtKB: Q9NPI83   

Export aliases for FANCF gene to outside databases

Previous GC identifers: GC11M024061 GC11M023445 GC11M022683 GC11M022608 GC11M022327


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FANCF Gene:
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called
BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called
PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous
recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents,
increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group
do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This
gene encodes the protein for complementation group F. (provided by RefSeq, Jul 2008)

GeneCards Summary for FANCF Gene:
FANCF (Fanconi anemia, complementation group F) is a protein-coding gene. Diseases associated with FANCF include fanconi anemia, complementation group f, and fancf-related fanconi anemia.

UniProtKB/Swiss-Prot: FANCF_HUMAN, Q9NPI8
Function: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May
be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By
similarity)

Gene Wiki entry for FANCF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the FANCF gene promoter:
         Elk-1   GATA-3   Pax-5   Tal-1beta   E47   E2F-1   E2F   FOXO4   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFANCF promoter sequence
   Search Chromatin IP Primers for FANCF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FANCF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15   Ensembl cytogenetic band:  11p14.3   HGNC cytogenetic band: 11p15

FANCF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FANCF gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M022600:  view genomic region     (about GC identifiers)

Start:
22,644,079 bp from pter      End:
22,647,387 bp from pter
Size:
3,309 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FANCF_HUMAN, Q9NPI8 (See protein sequence)
Recommended Name: Fanconi anemia group F protein  
Size: 374 amino acids; 42254 Da
Subunit: Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9
and FANCM. The complex is not found in FA patients. In complex with FANCA, FANCG and FANCL, but not with FANCC,
nor FANCE, interacts with HES1; this interaction may be essential for the stability and nuclear localization of
FA core complex proteins
1 PDB 3D structure from and Proteopedia for FANCF:
2IQC (3D)    
Secondary accessions: Q52LM0

Explore the universe of human proteins at neXtProt for FANCF: NX_Q9NPI8

Explore proteomics data for FANCF at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FANCF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_073562.1  
    ENSEMBL proteins: 
     ENSP00000330875  
    Reactome Protein details: Q9NPI8

    FANCF Human Recombinant Protein Products:

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    Novus Biologicals FANCF Proteins
    Novus Biologicals FANCF Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FANCF

     
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    antibodies-online proteins for FANCF (4 products) 

     
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    antibodies-online antibodies for FANCF (30 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FANC: Fanconi anemia, complementation groups

    ProtoNet protein and cluster: Q9NPI8


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FANCF_HUMAN, Q9NPI8
    Function: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May
    be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By
    similarity)

         Genatlas biochemistry entry for FANCF:
    putative RNA binding protein,highly homolog to the prokaryotic RNA-binding protein ROM,intronless

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI11063725
         
    Find genes that share ontologies with FANCF           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for FANCF:
     Cell cycle / mitosis defect  G0/1 arrest  Increased G1 DNA content  Synthetic lethal with paclitax 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FANCF
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FANCF (see all 15):
    hsa-miR-320a hsa-miR-30c hsa-miR-320d hsa-miR-3201 hsa-miR-30d hsa-miR-548g hsa-miR-30a hsa-miR-320b
    SwitchGear 3'UTR luciferase reporter plasmidFANCF 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FANCF

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FANCF_HUMAN, Q9NPI8: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    extracellular1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0043240Fanconi anaemia nuclear complex IDA--

    Find genes that share ontologies with FANCF           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FANCF About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1BRCA1 Pathway
    BRCA1 Pathway
    Fanconi's Anaemia Pathway0.00
    2DNA Repair
    DNA Repair0.45
    3Chks in Checkpoint Regulation
    DNA Repair Mechanisms0.32
    4Fanconi Anemia pathway (REACTOME)
    Fanconi Anemia pathway
    5Fanconi anemia pathway (KEGG)
    Fanconi anemia pathway


    Find genes that share SuperPaths with FANCF           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FANCF
        Fanconi's Anaemia Pathway
    BRCA1 Pathway
    DNA Repair Mechanisms

    1 BioSystems Pathway for FANCF
        BARD1 signaling events


    1 Reactome Pathway for FANCF
        Fanconi Anemia pathway


    1 Kegg Pathway  (Kegg details for FANCF):
        Fanconi anemia pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FANCF
    Interactions:

        GeneGlobe Interaction Network for FANCF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FANCF (Q9NPI81, 2, 3 ENSP000003308754) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FANCGO152871, 2, 3, ENSP000003679104EBI-81589,EBI-81610 MINT-19449 MINT-19448 I2D: score=5 STRING: ENSP00000367910
    MARK3P274482, 3, ENSP000004113974MINT-63628 I2D: score=4 STRING: ENSP00000411397
    FANCAO153601, 3, ENSP000003739524EBI-81589,EBI-81570 I2D: score=3 STRING: ENSP00000373952
    OLFM2O958972, 3MINT-63328 I2D: score=4 
    FANCEQ9HB962, 3, ENSP000002297694MINT-45826 I2D: score=3 STRING: ENSP00000229769
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair TAS--
    GO:0008150biological_process ND--

    Find genes that share ontologies with FANCF           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FANCF

    1 Novoseek inferred chemical compound relationship for FANCF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mitomycin c 74.5 4 12637330 (1), 12444097 (1), 17082180 (1)



    Find genes that share compounds with FANCF           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FANCF gene: 
    NM_022725.3  

    Unigene Cluster for FANCF:

    Fanconi anemia, complementation group F
    Hs.632151  [show with all ESTs]
    Unigene Representative Sequence: NM_022725
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000327470(uc001mql.1)
    miRNA
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    hsa-miR-320a hsa-miR-30c hsa-miR-320d hsa-miR-3201 hsa-miR-30d hsa-miR-548g hsa-miR-30a hsa-miR-320b
    SwitchGear 3'UTR luciferase reporter plasmidFANCF 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat FANCF
      QuantiFast Probe-based Assays in human, mouse, rat FANCF

    Additional mRNA sequence: 

    AF181994.1 AF181995.1 AK001716.2 AK023153.1 AK223277.1 BC017792.1 BC035346.1 BC047028.1 
    BC063038.1 BC093867.1 BC101807.1 BX640996.1 

    7 DOTS entries:

    DT.408917  DT.120707290  DT.75192878  DT.95164586  DT.95164585  DT.100661874  DT.99946085 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FANCF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGCCATCT
    FANCF Expression
    About this image

    FANCF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FANCF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632151
        Custom PCR Arrays for FANCF
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FANCF gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fancf1 , 5 Fanconi anemia, complementation group F1, 5 61.11(n)1
    53.27(a)1
      7 (32.87 cM)5
    1000406081  NM_001115087.11  NP_001108559.11 
     518605775 
    chicken
    (Gallus gallus)
    Aves FANCF1 Fanconi anemia, complementation group F 53.12(n)
    42.11(a)
      101750641  XM_004941330.1  XP_004941387.1 
    lizard
    (Anolis carolinensis)
    Reptilia FANCF6
    Fanconi anemia, complementation group F
    42(a)
    1 ↔ 1
    1(58810112-58811050)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fancf1 Fanconi anemia, complementation group F 43(n)
    28.7(a)
      100145108  NM_001126623.1  NP_001120095.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fancf1 Fanconi anemia, complementation group F 43.48(n)
    31.37(a)
      692250  NM_001045234.2  NP_001038699.2 


    ENSEMBL Gene Tree for FANCF (if available)
    TreeFam Gene Tree for FANCF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FANCF gene
    1 SIMAP similar gene for FANCF using alignment to 2 protein entries:     FANCF_HUMAN (see all proteins):
    DKFZp686L16252

    Find genes that share paralogs with FANCF           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FANCF (see all 174)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048942221,2
    Cpathogenic122571592(-) CGTTAC/GCACCT 2 Y * stg10--------
    rs1048942211,2
    Cpathogenic122571903(-) TTCTGC/TAGCAC 2 Q * stg10--------
    rs1847865631,2
    --22568165(+) AATATA/GGTAAG 1 -- ds50010--------
    rs3777191,2
    C,F,H--22568166(+) ATATGA/GTAAGT 1 -- ds500120Minor allele frequency- G:0.03NS EA NA WA CSA 919
    rs1900051121,2
    --22568184(+) GTAAAA/GGCATG 1 -- ds50010--------
    rs1813994611,2
    --22568252(+) AACAAA/GTATTT 1 -- ds50010--------
    rs1467105991,2
    --22568275(+) AACTGA/GGAAGT 1 -- ds50010--------
    rs1848475571,2
    C--22568283(+) AGTGAA/TACATA 1 -- ds50010--------
    rs1389016591,2
    --22568287(+) AAACAG/TAGAGA 1 -- ds50010--------
    rs456171391,2
    C,F--22568394(-) TTTCTG/ACTTTA 1 -- ds50015Minor allele frequency- A:0.03NS 130

    HapMap Linkage Disequilibrium report for FANCF (22644079 - 22647387 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FANCF: --
    Human Gene Mutation Database (HGMD): FANCF
    Locus Specific Mutation Databases (LSDB): FANCF

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FANCF
    DNA2.0 Custom Variant and Variant Library Synthesis for FANCF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613897   
    OMIM disorders: 603467  
    UniProtKB/Swiss-Prot: FANCF_HUMAN, Q9NPI8
  • Fanconi anemia complementation group F (FANCF) [MIM:603467]: A disorder affecting all bone marrow
    elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb
    malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the
    cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased
    chromosome breakage) and defective DNA repair. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 12 diseases for FANCF:    
    About MalaCards
    fanconi anemia, complementation group f    fancf-related fanconi anemia    fanconi anemia, complementation group b    fanconi anemia, complementation group e
    gnathodiaphyseal dysplasia    fanconi anemia, complementation group m    fanconi's anemia    sporadic breast cancer
    fanconi anemia, complementation group c    breast cancer susceptibility    ovarian cancer    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for FANCF:
    Bone marrow disease     Anemia

    Find genes that share disorders with FANCF           About GenesLikeMe

    9 Novoseek inferred disease relationships for FANCF gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fanconis anemia 95.2 7 16466850 (1), 12239156 (1), 12351379 (1), 15262960 (1) (see all 7)
    hnscc 52.5 6 16466850 (3), 14647419 (2), 17409780 (1)
    anemia 41.3 3 12001267 (1), 10615118 (1), 14617007 (1)
    cancer 41 3 18607065 (1), 12351379 (1), 19861535 (1)
    leukemia 27.7 2 16803569 (2)
    ovarian cancer 20.3 11 16418574 (7), 14647419 (1)
    breast cancer 15.9 4 17932744 (2), 14695169 (1)
    primary tumor 6.95 1 14647419 (1)
    tumors 2.83 6 19236379 (1), 16418574 (1), 18000367 (1), 17932744 (1)

    GeneTests: FANCF
    GeneReviews: FANCF
    Genetic Association Database (GAD): FANCF
    Human Genome Epidemiology (HuGE) Navigator: FANCF (7 documents)

    Export disorders for FANCF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FANCF gene, integrated from 10 sources (see all 86):
    (articles sorted by number of sources associating them with FANCF)
        Utopia: connect your pdf to the dynamic
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    1. Structural determinants of human FANCF protein that function in the assembly of a DNA damage signaling complex. (PubMed id 17082180)1, 2, 9 Kowal P.... Ellenberger T. (J. Biol. Chem. 2007)
    2. The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG. (PubMed id 11063725)1, 2, 9 de Winter J.P.... Joenje H. (Hum. Mol. Genet. 2000)
    3. The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM. (PubMed id 10615118)1, 2, 9 de Winter J.P.... Joenje H. (Nat. Genet. 2000)
    4. Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. (PubMed id 20496165)1, 4 Monsees G.M....Han J. (Breast Cancer Res. Treat. 2011)
    5. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (Gynecol. Oncol. 2009)
    6. The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features. (PubMed id 19536649)1, 4 Barroso E....Ribas G. (Breast Cancer Res. Treat. 2009)
    7. Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk. (PubMed id 19690177)1, 4 McWilliams R.R....Petersen G.M. (amp 2009)
    8. HES1 is a novel interactor of the Fanconi anemia core complex. (PubMed id 18550849)1, 2 Tremblay C.S....Carreau M. (Blood 2008)
    9. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (amp 2008)
    10. A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. (PubMed id 16116422)1, 2 Meetei A.R.... Wang W. (Nat. Genet. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2188 HGNC: 3587 Ensembl:ENSG00000183161 euGenes: HUgn2188 ECgene: FANCF Kegg: 2188
    H-InvDB: FANCF

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FANCF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FANCF Genetics and Cytogenetics in Oncology and Haematology
    Fanconi Anemia Mutation Databasehttp://www.rockefeller.edu/fanconi/mutate/jumpf.html
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=FANCF[genesymbol]
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fancf/

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FANCF gene:
    Search GeneIP for patents involving FANCF

    GeneCards and IP:
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