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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FANCE Gene

protein-coding   GIFtS: 62
GCID: GC06P036308

Fanconi Anemia, Complementation Group E


(Previous symbol: FACE)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fanconi Anemia, Complementation Group E1 2
FACE1 2 3
FAE2
Fanconi Anemia Group E Protein2
Protein FACE3

External Ids:    HGNC: 35861   Entrez Gene: 21782   Ensembl: ENSG000001120397   OMIM: 6139765   UniProtKB: Q9HB963   

Export aliases for FANCE gene to outside databases

Previous GC identifers: GC06P035422 GC06P035466 GC06P035528 GC06P035140 GC06P035565 GC06P035783


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FANCE Gene:
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called
BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called
PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous
recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents,
increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group
do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This
gene encodes the protein for complementation group E. (provided by RefSeq, Jul 2008)

GeneCards Summary for FANCE Gene: 
FANCE (Fanconi anemia, complementation group E) is a protein-coding gene. Diseases associated with FANCE include fance-related fanconi anemia, and fanconi anemia, complementation group b, and among its related super-pathways are Fanconi's Anaemia Pathway and Nucleotide Excision Repair. GO annotations related to this gene include protein binding and molecular_function.

UniProtKB/Swiss-Prot: FANCE_HUMAN, Q9HB96
Function: As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear
accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2

Gene Wiki entry for FANCE Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FANCE gene promoter:
         Bach1   NF-1   NF-1/L   RFX1   Olf-1   E47   CREB   deltaCREB   ARP-1   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFANCE promoter sequence
   Search SABiosciences Chromatin IP Primers for FANCE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FANCE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22-p21   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p22-p21

FANCE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FANCE gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P036308:  view genomic region     (about GC identifiers)

Start:
35,420,138 bp from pter      End:
35,434,881 bp from pter
Size:
14,744 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FANCE_HUMAN, Q9HB96 (See protein sequence)
Recommended Name: Fanconi anemia group E protein  
Size: 536 amino acids; 58711 Da
Subunit: Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9
and FANCM. The complex is not found in FA patients. Interacts with FANCC and FANCD2
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for FANCE:
2ILR (3D)    
Secondary accessions: A8K907 Q4ZGH2

Explore the universe of human proteins at neXtProt for FANCE: NX_Q9HB96

Explore proteomics data for FANCE at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. Phosphorylation by CHEK1 at Thr-346 and Ser-374 regulates its function in DNA cross-links repair
  • UniProtKB: Ubiquitinated. Phosphorylation by CHEK1 induces polyubiquitination and degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HB96

  • FANCE Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FANCE Protein Expression
    REFSEQ proteins: NP_068741.1  
    ENSEMBL proteins: 
     ENSP00000229769  
    Reactome Protein details: Q9HB96
    Human Recombinant Protein Products for FANCE: 
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    Novus Biologicals FANCE Protein
    Novus Biologicals FANCE Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FANCE 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS11001585
    GO:0005654nucleoplasm TAS--
    GO:0043240Fanconi anaemia nuclear complex IDA--

    FANCE for ontologies           About GeneDecksing



    FANCE Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for FANCE 

    Assay Products for FANCE: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FANC: Fanconi anemia, complementation groups

    1 InterPro protein domain:
     IPR021025 Fanconi_anaemia_gr_E_prot_C

    Graphical View of Domain Structure for InterPro Entry Q9HB96

    ProtoNet protein and cluster: Q9HB96


    FANCE for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FANCE_HUMAN, Q9HB96
    Function: As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear
    accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI11157805
         
    FANCE for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FANCE:
     Decreased Hepatitis C virus re  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FANCE 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FANCE

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FANCE 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FANCE 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FANCE
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate FANCE (see all 9):
    hsa-miR-4254 hsa-miR-330-5p hsa-miR-944 hsa-miR-4299 hsa-miR-650 hsa-miR-326 hsa-miR-3165 hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidFANCE 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FANCE About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Fanconi Anemia pathway
    Fanconi's Anaemia Pathway0.43
    BARD1 signaling events0.41
    Fanconi Anemia pathway0.43
    2Nucleotide Excision Repair
    DNA Repair0.46
    3Chks in Checkpoint Regulation
    DNA Repair Mechanisms0.32
    4BRCA1 Pathway
    BRCA1 Pathway
    5Fanconi anemia pathway
    Fanconi anemia pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FANCE
        Fanconi's Anaemia Pathway
    BRCA1 Pathway
    DNA Repair Mechanisms

    1 BioSystems Pathway for FANCE
        BARD1 signaling events

    2        Reactome Pathways for FANCE
        DNA Repair
    Fanconi Anemia pathway


    1         Kegg Pathway  (Kegg details for FANCE):
        Fanconi anemia pathway


    FANCE for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FANCE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for FANCE (Q9HB961, 2, 3 ENSP000002297694) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FANCAO153602, 3, ENSP000003739524MINT-45825 I2D: score=5 STRING: ENSP00000373952
    FANCGO152872, 3, ENSP000003679104MINT-45827 I2D: score=5 STRING: ENSP00000367910
    FANCD2Q9BXW91, 2, 3, ENSP000002876474EBI-396803,EBI-359343 MINT-19474 MINT-45828 MINT-19475 MINT-5206796 I2D: score=4 STRING: ENSP00000287647
    FANCCQ005971, 2, 3, ENSP000002890814EBI-396803,EBI-81625 MINT-19451 MINT-19450 I2D: score=4 STRING: ENSP00000289081
    FANCFQ9NPI82, 3, ENSP000003308754MINT-45826 I2D: score=3 STRING: ENSP00000330875
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair TAS--

    FANCE for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FANCE for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FANCE

    1 Novoseek inferred chemical compound relationship for FANCE gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mitomycin c 55.8 1 12239156 (1)

    Search CenterWatch for drugs/clinical trials and news about FANCE

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FANCE gene: 
    NM_021922.2  

    Unigene Cluster for FANCE:

    Fanconi anemia, complementation group E
    Hs.302003  [show with all ESTs]
    Unigene Representative Sequence: BC046359
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000229769(uc003oko.1 uc010jvw.1)
    miRNA
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    hsa-miR-4254 hsa-miR-330-5p hsa-miR-944 hsa-miR-4299 hsa-miR-650 hsa-miR-326 hsa-miR-3165 hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidFANCE 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FANCE
    Clone
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    OriGene ORF clones in mouse, rat for FANCE
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    GenScript: all cDNA clones in your preferred vector: FANCE (NM_021922)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FANCE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FANCE
    Sirion Biotech Customized lentivirus for stable overexpression of FANCE 
                         Customized lentivirus expression plasmids for stable overexpression of FANCE 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FANCE
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FANCE

    Additional mRNA sequence: 

    AF265210.1 AK292522.1 AK312617.1 BC046359.1 

    2 DOTS entries:

    DT.75179684  DT.95374718 

    24/39 AceView cDNA sequences (see all 39):

    NM_021922 BU154023 BI060903 CR605350 AF265210 BI060775 BC046359 BQ379868 
    AL549594 BI061019 BX334386 AL571980 BX334387 BI061089 BQ437572 AW028850 
    BI222328 BX390433 BX356757 CB144916 BX371735 BG254606 BI912628 AL546581 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FANCE    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
    SP1:                          -                                               -                     
    SP2:                          -     -                                         -                     
    SP3:                                                                                                
    SP4:                                                                                                


    ECgene alternative splicing isoforms for FANCE

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FANCE expression in normal human tissues (normalized intensities)      FANCE embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATATTATGA
    FANCE Expression
    About this image


    FANCE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/33 selected tissues (see all 33) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See FANCE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FANCE

    SOURCE GeneReport for Unigene cluster: Hs.302003
        SABiosciences Custom PCR Arrays for FANCE
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FANCE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FANCE gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fance1 , 5 Fanconi anemia, complementation group E1, 5 74.52(n)1
    66.48(a)1
      17 (14.65 cM)5
    727751  NM_001163819.11  NP_001157291.11 
     283135305 
    chicken
    (Gallus gallus)
    Aves FANCE6
    Uncharacterized protein
    37(a)
    1 ↔ 1
    26(4021842-4025891)
    lizard
    (Anolis carolinensis)
    Reptilia FANCE6
    Uncharacterized protein
    53(a)
    1 ↔ 1
    4(120427393-120433356)
    zebrafish
    (Danio rerio)
    Actinopterygii fance1 Fanconi anemia, complementation group E 48.02(n)
    36.53(a)
      565685  NM_001040634.1  NP_001035724.1 


    ENSEMBL Gene Tree for FANCE (if available)
    TreeFam Gene Tree for FANCE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/437 SNPs in FANCE are shown (see all 437)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0380224
    ----see VAR_0380222 P Q mis40--------
    rs1491060091,2
    C--35332840(+) GACAT-/GGAGGAAT 1 -- us2k10--------
    rs94700281,2
    C,F--35332858(+) AGGGCT/CCCTGG 1 -- us2k11Minor allele frequency- C:0.09WA 118
    rs1427151271,2
    --35332954(+) AATGCA/CCCTAA 1 -- us2k10--------
    rs1461555051,2
    --35332990(+) TGGTCC/TGCTCA 1 -- us2k10--------
    rs77589781,2
    C,F,A,H--35333073(+) AGCTTG/CTGGAA 1 -- us2k125Minor allele frequency- C:0.45NS EA NA WA CSA 2772
    rs1401625461,2
    --35333291(+) GGCTTC/TTTAGC 1 -- us2k10--------
    rs1851500331,2
    --35333368(+) AACATC/TCCCTG 1 -- us2k10--------
    rs1902965261,2
    --35333556(+) TTTCCA/GTACTA 1 -- us2k10--------
    rs69076781,2
    C,F,A,H--35333585(+) CTCCTC/TTCTGT 1 -- us2k122Minor allele frequency- T:0.45NS EA NA WA CSA 2350

    HapMap Linkage Disequilibrium report for FANCE (35420138 - 35434881 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FANCE:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv528351CNV Loss19592680
    nsv830641CNV Loss17160897
    nsv885799CNV Loss21882294
    nsv519370CNV Loss19592680


    Human Gene Mutation Database (HGMD): FANCE

    Locus Specific Mutation Databases (LSDB): FANCE
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613976    OMIM disorders: --

    UniProtKB/Swiss-Prot: FANCE_HUMAN, Q9HB96
  • Fanconi anemia complementation group E (FANCE) [MIM:600901]: A disorder affecting all bone marrow
    elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb
    malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the
    cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased
    chromosome breakage) and defective DNA repair. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 17 diseases for FANCE:    About MalaCards
    fance-related fanconi anemia    fanconi anemia, complementation group b    anemia    fanconi's anemia
    fetal alcohol syndrome    hereditary pancreatitis    leukopenia    familial breast cancer
    bloom syndrome    sporadic breast cancer    breast cancer susceptibility    breast cancer
    alcoholism    ovarian cancer    pancreatic cancer    pancreatitis
    squamous cell carcinoma

    2 diseases from the University of Copenhagen DISEASES database for FANCE:
    Bone marrow disease     Anemia

    FANCE for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for FANCE gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fanconis anemia 94 8 12239156 (3), 12351379 (1), 16127171 (1), 10205272 (1) (see all 6)
    hnscc 49.5 2 17409780 (1), 16466850 (1)
    cancer 36.7 2 12351379 (1), 19861535 (1)
    anemia 20.8 2 17308347 (1), 12001267 (1)
    breast cancer 12.5 2 14695169 (1)

    GeneTests: FANCE
    GeneReviews: FANCE
    Genetic Association Database (GAD): FANCE
    Human Genome Epidemiology (HuGE) Navigator: FANCE (8 documents)

    Export disorders for FANCE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FANCE gene, integrated from 9 sources (see all 76):
    (articles sorted by number of sources associating them with FANCE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a cDNA representing the Fanconi anemia complementation group E gene. (PubMed id 11001585)1, 2, 3, 9 de Winter J.P....Joenje H. (2000)
    2. Regulation of Rev1 by the Fanconi anemia core complex. (PubMed id 22266823)1, 2 Kim H....D'Andrea A.D. (2012)
    3. Comprehensive screen of genetic variation in DNA repa ir pathway genes and postmenopausal breast cancer risk. (PubMed id 20496165)1, 4 Monsees G.M....Han J. (2010)
    4. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    5. Genetic variation in genes interacting with BRCA1/2 a nd risk of breast cancer in the Cypriot population. (PubMed id 19714462)1, 4 Loizidou M.A....Kyriacou K. (2010)
    6. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (2009)
    7. The Fanconi anemia family of genes and its correlatio n with breast cancer susceptibility and breast cancer features. (PubMed id 19536649)1, 4 Barroso E....Ribas G. (2009)
    8. Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk. (PubMed id 19690177)1, 4 McWilliams R.R....Petersen G.M. (2009)
    9. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (2008)
    10. Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway. (PubMed id 17296736)1, 2 Wang X....D'Andrea A.D. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2178 HGNC: 3586 AceView: FANCE Ensembl:ENSG00000112039 euGenes: HUgn2178
    ECgene: FANCE Kegg: 2178 H-InvDB: FANCE

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FANCE Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FANCE Genetics and Cytogenetics in Oncology and Haematology
    Fanconi Anemia Mutation Databasehttp://www.rockefeller.edu/fanconi/mutate/jumpe.html
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/FANCE
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fance/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FANCE gene:
    Search GeneIP for patents involving FANCE

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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