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FANCD2OS Gene

protein-coding   GIFtS: 32
GCID: GC03M010125

FANCD2 Opposite Strand

(Previous name: chromosome 3 open reading frame 24)
(Previous symbol: C3orf24)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
FANCD2 Opposite Strand1 2
C3orf241 2 3
Fanconi Anemia Group D2 Protein Opposite Strand Transcript Protein2 3
Chromosome 3 Open Reading Frame 241
FANCD2 Opposite Strand Protein2

External Ids:    HGNC: 286231   Entrez Gene: 1157952   Ensembl: ENSG000001637057   UniProtKB: Q96PS13   
ORGUL members:         

Export aliases for FANCD2OS gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FANCD2OS Gene:
This gene encodes a conserved protein of unknown function. (provided by RefSeq, Jan 2013)

GeneCards Summary for FANCD2OS Gene:
FANCD2OS (FANCD2 opposite strand) is a protein-coding gene.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for FANCD2OS
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FANCD2OS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FANCD2OS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.3   Ensembl cytogenetic band:  3p25.3   HGNC cytogenetic band: 3p25.3

FANCD2OS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FANCD2OS gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M010125:  view genomic region     (about GC identifiers)

Start:
10,123,001 bp from pter      End:
10,149,915 bp from pter
Size:
26,915 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FACOS_HUMAN, Q96PS1 (See protein sequence)
Recommended Name: FANCD2 opposite strand protein  
Size: 177 amino acids; 20188 Da

Explore the universe of human proteins at neXtProt for FANCD2OS: NX_Q96PS1

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins (2 alternative transcripts): 
    NP_001158311.1  NP_775743.1  

    ENSEMBL proteins: 
     ENSP00000429663   ENSP00000429589   ENSP00000429608  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR027966 FANCD2OS

    Graphical View of Domain Structure for InterPro Entry Q96PS1

    ProtoNet protein and cluster: Q96PS1


    Find genes that share domains with FANCD2OS           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FANCD2OS
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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      --

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FANCD2OS
    Interactions:

        Search GeneGlobe Interaction Network for FANCD2OS

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FANCD2OS (FACOS)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FANCD2OS gene (2 alternative transcripts): 
    NM_001164839.1  NM_173472.1  

    Unigene Cluster for FANCD2OS:

    FANCD2 opposite strand
    Hs.190413  [show with all ESTs]
    Unigene Representative Sequence: NM_173472
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000431315 ENST00000450616 ENST00000436517 ENST00000524279(uc003buz.3)
    ENST00000453223 ENST00000450660(uc003bva.2)
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    Additional mRNA sequence: 

    AF230334.1 AY248899.1 BC028122.1 

    5 DOTS entries:

    DT.208037  DT.95177727  DT.91721692  DT.95304282  DT.40308918 

    Selected AceView cDNA sequences (see all 26):

    BX109433 AF230334 NM_173472 BX360156 BC028122 BI826039 BX098403 AW303549 
    AY248899 AA421396 AW119172 AA421292 BE551735 AW665341 AA824244 AW665592 
    BU568302 AA626238 AW074860 AA759162 AA609090 AA609512 AI028713 AW070485 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FANCD2OS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FANCD2OS Expression
    About this image

    FANCD2OS Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.190413
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FANCD2OS gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fancd2os1 , 5 RIKEN cDNA 4931417G12 gene5
    Fancd2 opposite strand1
    87.19(n)1
    92.09(a)1
      6 (52.80 cM)5
    709791  NM_027633.31  NP_081909.21 
     1135967615 
    chicken
    (Gallus gallus)
    Aves C3ORF241 chromosome 2 open reading frame, human C3orf24 54.83(n)
    50(a)
      776543  XM_004939538.1  XP_004939595.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    55(a)
    48(a)
    many → 1
    many → 1
    6(45947439-45947969)
    GL343859.1(64254-64790)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fancd2os1 FANCD2 opposite strand 60.69(n)
    53.18(a)
      100036698  NM_001097248.1  NP_001090717.1 


    ENSEMBL Gene Tree for FANCD2OS (if available)
    TreeFam Gene Tree for FANCD2OS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FANCD2OS gene
    2 SIMAP similar genes for FANCD2OS using alignment to 2 protein entries:     FACOS_HUMAN (see all proteins):
    L3MBTL2    NCF1

    Find genes that share paralogs with FANCD2OS           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FANCD2OS (see all 181)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1832430921,2
    --10144157(+) AAGAAA/TGTCAA 1 -- int10--------
    rs1119501081,2
    C,F--10144376(+) CAAAAC/AATTAG 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1870576501,2
    C--10144400(+) CGGGCA/GCCTGT 1 -- int10--------
    rs1918473071,2
    --10144640(+) ACCTAC/GTTACA 1 -- int10--------
    rs1457706251,2
    C--10144679(+) GTCACC/TGCTGT 1 -- int10--------
    rs2005089891,2
    C--10144779(+) CTACT-/AAAAAAA 1 -- int10--------
    rs791287161,2
    C--10144857(+) TGAGGA/TGGGCA 1 -- int10--------
    rs778882641,2
    F--10145103(+) ATAATC/ACAAAA 1 -- int11Minor allele frequency- A:0.50NA 4
    rs1834066411,2
    --10145306(+) TTCAGC/TTAAAA 1 -- int10--------
    rs779437211,2
    C,F--10145386(+) GCCAGT/GCTGTA 2 -- int1 ds50011Minor allele frequency- G:0.00CSA 1

    HapMap Linkage Disequilibrium report for FANCD2OS (10123001 - 10149915 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FANCD2OS: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FANCD2OS
    DNA2.0 Custom Variant and Variant Library Synthesis for FANCD2OS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FANCD2OS gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FANCD2OS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    4. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
    5. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 115795 HGNC: 28623 AceView: MGC40179 Ensembl:ENSG00000163705 euGenes: HUgn115795
    ECgene: FANCD2OS H-InvDB: FANCD2OS

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FANCD2OS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FANCD2OS gene:
    Search GeneIP for patents involving FANCD2OS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
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     Browse ELISAs at Cloud-Clone Corp.
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     Browse ESI BIO Cell Lines and PureStem Progenitors for FANCD2OS
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     SwitchGear 3'UTR luciferase reporter plasmids for FANCD2OS
     Browse SwitchGear Promoter luciferase reporter plasmids for FANCD2OS
     Search ThermoFisher Antibodies for FANCD2OS
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FANCD2OS
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FANCD2OS
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FANCD2OS
     LSBio Antibodies in human, mouse, rat for FANCD2OS
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     Browse compounds at ApexBio
     Search Addgene for plasmids for FANCD2OS
      Search eBioscience for proteins for FANCD2OS
      Search eBioscience for elisas for FANCD2OS
      eBioscience FlowRNA Probe Sets
           
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