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BRCA2 Gene

protein-coding GIFtS: 72

GC13P031787

breast cancer 2, early onset
(Previous names: Fanconi anemia, complementation group D1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: FANCD1, FACD, FANCD)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BRCC2 ^¹, ²
BROVCA2 ^², ⁵
FACD ^², ³
FAD ^¹, ²
FAD1 ^¹, ²
FANCB ^²
FANCD ^²
FANCD1 ^², ³, ⁵
OTTHUMP00000018803 ^²
OTTHUMP00000042401 ^²

Descriptions
BRCA1/BRCA2-containing complex, subunit 2 ^²
Fanconi anemia group D1 protein ^³
Fanconi anemia, complementation group D1 ^¹
breast and ovarian cancer susceptibility gene, early onset ^²
breast cancer 2 tumor suppressor ^²
breast cancer 2, early onset ^²
breast cancer susceptibility protein BRCA2 ^²

External Ids
HGNC: 1101¹
Entrez Gene: 675²
UniProtKB: P51587³
Ensembl: ENSG00000139618⁷

Search outside databases for aliases for BRCA2 gene

Previous GC identifers: GC13P030875 GC13P026876 GC13P031826 GC13P030687

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for BRCA2:

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing

breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability,

specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein

contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to

the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene,

as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type

allele. [provided by RefSeq]

UniProtKB/Swiss-Prot: BRCA2_HUMAN, P51587

Function: Involved in double-strand break repair and/or homologous recombination. May participate

in S phase checkpoint activation

Gene Wiki entry for BRCA2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the BRCA2 gene

Entrez Gene cytogenetic band: 13q12.3 Ensembl cytogenetic band: 13q13.1 HGNC cytogenetic band: 13q12-q13

BRCA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P031787: (about GC identifiers)

Start:	31,787,617 bp from pter
End:	31,871,809 bp from pter
Size:	84,193 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000013.9 NT_024524.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: BRCA2_HUMAN, P51587 (See protein sequence)

Recommended Name: Breast cancer type 2 susceptibility protein

Size: 3418 amino acids; 384225 Da

Subunit: Interacts with RAD51 and DSS1. Interacts with ubiquitinated FANCD2. Interacts with PALB2,

enables the recombinational repair and checkpoints functions. Interacts with WDR16

PDB structures from and Proteopedia :

1N0W (3D)

Secondary accessions: O00183 O15008 Q13879

Post-translational modifications:

Phosphorylated by ATM upon irradiation-induced DNA damage¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000050.2

ENSEMBL proteins:

ENSP00000369497

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (BRCA2)
	Human Recombinant Proteins from Abnova (BRCA2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	9560268 9774970 17286961
GO:0005654	nucleoplasm	EXP	12606939
GO:0005737	cytoplasm	IEA	--
GO:0005813	centrosome	IDA	17286961
GO:0030141	secretory granule	IDA	8589722

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Antibodies for BRCA2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of BRCA2
	Sigma-Aldrich Antibodies for BRCA2
	R&D Systems Antibodies for BRCA2
	Antibodies from Abcam (BRCA2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (BRCA2)
	Novus Biologicals Antibodies for BRCA2

Assays for BRCA2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P51587

ProtoNet protein and cluster: P51587

UniProtKB/Swiss-Prot: BRCA2_HUMAN, P51587

Similarity: Contains 8 BRCA2 repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BRCA2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BRCA2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000059

Applied Biosystems Silencer® siRNAs for BRCA2

Sigma-Aldrich siRNA and siRNA Panels for BRCA2

Sigma-Aldrich shRNA Panels and shRNA for BRCA2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000059
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000059
untagged cDNA clone in CMV expression vector: NM_000059

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000059

UniProtKB/Swiss-Prot: BRCA2_HUMAN, P51587

Function: Involved in double-strand break repair and/or homologous recombination. May participate

in S phase checkpoint activation

Genatlas biochemistry entry for BRCA2:

BRCA2 homolog to C elegans T07E3 uncharacterized gene,expressed in many tissues and most abundant

in the S phase,complexing and interacting with phosphorylated BRCA1,RAD51 and RAD52 for cell cycle

control and DNA repair through homologous recombination,also involved in embryonic cellular

proliferation

15/18 MGI mutant phenotypes (inferred from 14 alleles) (MGI details for Brca2) (see all 18 ):

behavior/neurological	cellular	embryogenesis	endocrine/exocrine gland	growth/size
hematopoietic system	homeostasis/metabolism	immune system	lethality-postnatal	lethality-prenatal/perinatal
life span-post-weaning/aging	limbs/digits/tail	nervous system	normal	reproductive system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003697	single-stranded DNA binding	IEA	--
GO:0004402	NOT histone acetyltransferase activity	IDA	9824164
GO:0005515	protein binding	IPI	9774970 10373512 11597317 12242698 15930293 15967112 16099937 16275750 17515903
GO:0016563	transcription activator activity	IDA	9619837
GO:0043015	gamma-tubulin binding	IPI	17286961

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for BRCA2 (Your Favorite Gene powered by Ingenuity)

Role of BRCA1 in DNA Damage Response

GeneDecks BRCA2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for BRCA2

5/75 Interacting proteins for BRCA2 (ENSP00000369497³ P51587^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 75 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FANCD2	Q9BXW9¹	STRING (score=.999) EBI-79792, EBI-359343
SHFM1	P60896¹	STRING (score=.996) EBI-79792, EBI-79819
RAD51	Q06609¹^,²	STRING (score=.999) EBI-79792, EBI-297202 MINT-4980796 MINT-4980473 MINT-4980518 MINT-4980488 MINT-4980408 MINT-4980567 MINT-4980502 EBI-79792, EBI-297202 MINT-4980796 MINT-4980473 MINT-4980518 MINT-4980488 MINT-4980408 MINT-4980567 MINT-4980502
ABL1	P00519¹	EBI-79792, EBI-375543
FYN	P06241¹	EBI-79792, EBI-515315

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5/30 Gene Ontology (GO) biological process terms (links to tree view) (see all 30 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000724	double-strand break repair via homologous recombination	IEA	--
GO:0001556	oocyte maturation	IEA	--
GO:0001833	inner cell mass cell proliferation	IEA	--
GO:0006289	nucleotide-excision repair	IMP	16845393
GO:0006310	DNA recombination	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BRCA2
10/20 Novoseek chemical compound relationships for BRCA2 gene (see all 20 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
nu1025	67.65	3	16251802 (1), 18990703 (1)
progesterone	32.82	10	14732925 (2), 11429050 (1), 12548582 (1), 15933754 (1) (see all 9)
3-aminobenzamide	13.89	2	16251802 (1)
phosphatidylinositol	5.24	7	15805113 (2), 16754685 (2), 10608806 (1)
estradiol	4.03	2	10375022 (1)
thymidine	2.24	1	11103814 (1)
gold	0.84	1	16825125 (1)
mspi	0.00	1	9365162 (1)
o6-methylguanine	0.00	1	19047179 (1)
polyacrylamide	0.00	1	17572079 (1)

About this table

1 PharmGKB drug compound relationship for BRCA2 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
docetaxel	CO	11400119

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BRCA2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BRCA2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000059

Sigma-Aldrich siRNA and siRNA Panels for BRCA2

Sigma-Aldrich shRNA Panels and shRNA for BRCA2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000059

REFSEQ mRNAs for BRCA2 gene:

NM_000059.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000059

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000059
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000059
                                 untagged cDNA clone in CMV expression vector: NM_000059

Additional cDNA sequence:

BC026160.1 BC047568.1 DQ897648.1

3 DOTS entries:

DT.212055 DT.91725304 DT.40111537

24/48 AceView cDNA sequences (see all 48 ):

BC026160 AL044849 BX102368 AI355687 U43746 BQ226936 BC047568 AL602008

NM_000059 BQ439258 BU568005 H48122 BM171992 BE552211 BV183238 BX496533

BG773203 AA741449 BM839248 AA215820 BG773127 AA280905 BG772619 AA767988

highest scoring ESTs for BRCA2:

AA740751 AA741449 AA767988 BF814836 BG166449 H48122 U43746 AA215820 AA280905 AA333018

Unigene Cluster for BRCA2:

Breast cancer 2, early onset

Hs.34012 [show with all ESTs]

Unigene Representative Sequence: NM_000059

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000380152

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

BRCA2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BRCA2

¹ / ² / ³

7 probe-sets matching BRCA2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1503_at²^{, 3}	U95-A	1	1.00	1.00	0.94	1.13	X95152	0.20	1.00	0.72	1
1989_at²^{, 3}	U95-A	1	1.00	1.00	0.74	0.75	U43746	0.80	0.88	0.84	1
1990_g_at²^{, 3}	U95-A	1	1.00	1.00	0.96	0.89	U43746	0.80	0.88	0.84	1
208368_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000059	0.60	1.00	0.82	1
214727_at²^{, 3}	U133-A	1	1.00	1.00	--	--	X95152	0.20	1.00	0.72	1
208368_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214727_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATTATAAGAA

SOURCE GeneReport for Unigene cluster: Hs.34012
Expression variation in blood from EXPOLDB for BRCA2
UniProtKB/Swiss-Prot: BRCA2_HUMAN, P51587
Tissue specificity: Highest levels of expression in breast and thymus, with slightly lower levels
in lung, ovary and spleen

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BRCA2 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	BRCA2¹	--	breast cancer 2, early onset	82.88(n) 71.13(a)	474180 NM_001006653.4 NP_001006654.2
chimpanzee (Pan troglodytes)	BRCA2¹	--	breast cancer 2, early onset	99.38(n) 99.09(a)	452526 XM_509619.2 XP_509619.2
rat (Rattus norvegicus)	Brca2¹	--	breast cancer 2	72.62(n) 59.07(a)	360254 NM_031542.1 NP_113730.1
mouse (Mus musculus)	Brca2^{1, 5}	5 (84.00 cM)⁵	breast cancer 2^{1, 5}	73.67(n)¹ 60.24(a)¹	12190¹ NM_001081001.1¹ NP_001074470.1¹ AI256696⁵ AK132864⁵ (see all 48)
chicken (Gallus gallus)	BRCA2¹	--	breast cancer 2, early onset	52.48(n) 38.82(a)	374139 NM_204276.1 NP_989607.1

About this table Species with no ortholog for BRCA2

ENSEMBL Gene Tree for BRCA2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: BRCA2_HUMAN, P51587

Polymorphism: Genetic variations in BRCA2 may underlie susceptibility to uveal melanoma

[MIM:155720]. Uveal melanoma is the most common type of ocular malignant tumor, consisting of

overgrowth of uveal melanocytes and often preceded by a uveal nevus

10/903 NCBI SNPs in BRCA2 are shown (see all 903 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 328)

AB	SNP ID	Valid	Chr 13 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs206116^1,2	A,C,F,H,O	31786483(-)	`GCAACC/TTTGGA`	1	--	ng5¹		19	NS EU EA WA NA MN	1500
	rs144848^1,2	A,C,F,H,O	31804729(-)	`CTGATT/GTGCTA`	1	H/N	mis¹		39	NS MN EA NA CSAM EU WA	3348
	rs1148321^1,2	A,C,F,H,O	31872288(+)	`TTAATA/TGCATG`	1	--	ng3¹		12	EU EA WA NS NA	1080
	rs1799943^1,2	A,C,F,H,O	31788572(+)	`ACCAAG/ACATTG`	1	--	ut5¹		27	MN CSAM EA NS NA EU WA	2580
--	rs206117^1,2	A,C,F,H	31786709(-)	`cacccG/AgccCA`	1	--	ng5¹		5	EU EA WA NS	580
	rs3092989^1,2	C,F,H,O	31787363(+)	`GAAAGG/AGATGG`	1	--	ng5¹ trp³		14	NS EU EA WA NA	1384
	rs15869^1,2	C,F,H,O	31871012(+)	`ATGAGA/CAAAGA`	1	--	ut3¹ trp³		24	MN EA NA EU WA CSAM NS	2362
	rs1799944^1,2	C,F,H,O	31809463(+)	`ACATGA/GACAAA`	1	N/D	mis¹		28	MN CSAM EA NS NA EU WA	2360
--	rs7334543^1,2	A,C,F,H	31871276(+)	`TTTACA/GAAGAA`	1	--	ut3¹ ese³ trp³		5	NS EU EA WA	568
	rs206115^1,2	A,C,F,H	31786473(-)	`ATTAGA/GAAAAG`	1	--	ng5¹ trp³		5	EU EA WA NS	586

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HapMap Linkage Disequilibrium images for BRCA2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600185

UniProtKB/Swiss-Prot: BRCA2_HUMAN, P51587

Defects in BRCA2 are a cause of genetic susceptibility to breast cancer (BC) [MIM:612555,

114480]; also called susceptibility to familial breast-ovarian cancer type 2 (BROVCA2). BC is an

extremely common malignancy, affecting one in eight women during their lifetime. A positive family

history has been identified as major contributor to risk of development of the disease, and this

link is striking for early-onset breast cancer. Mutations in BRCA2 are thought to be responsible

for some inherited breast cancer. It is linked with male breast cancer

Defects in BRCA2 are the cause of Fanconi anemia complementation group D type 1 (FANCD1)

[MIM:605724]. Fanconi anemia [MIM:227650] is an autosomal recessive disorder affecting all bone

marrow elements and associated with cardiac, renal, and limb malformations as well as dermal

pigmentary changes

10/93 Novoseek disease relationships for BRCA2 gene (see all 93 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ovarian cancer	94.48	1051	10560359 (7), 17196508 (6), 12237285 (5), 19066131 (5) (see all 99)
breast cancer	92.11	2059	9145678 (9), 11044354 (8), 18355772 (7), 10359546 (7) (see all 99)
prophylactic oophorectomy	91.40	37	15863145 (5), 9148160 (3), 12023993 (3), 18341607 (2) (see all 25)
germ-line mutation	89.74	135	10969800 (4), 17001151 (4), 14732925 (3), 12543786 (3) (see all 99)
bilateral breast cancer	85.55	25	11556836 (3), 10573018 (2), 19372713 (2), 15319244 (1) (see all 14)
cancer	80.55	520	14966099 (7), 10972993 (5), 10433620 (4), 17148771 (4) (see all 99)
fanconis anemia	77.97	41	16243825 (3), 14559878 (2), 17200671 (2), 17200672 (2) (see all 27)
fallopian tube cancer	71.38	6	16835424 (1), 12237285 (1), 15254695 (1), 19141781 (1) (see all 6)
li-fraumeni syndrome	71.08	5	10432928 (2), 11205230 (1), 10962444 (1), 17541742 (1)
peritoneal cancer	70.89	9	16835424 (3), 15516851 (1), 18268356 (1), 17617523 (1) (see all 6)

About this table

1 PharmGKB disease relationship for BRCA2 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Breast Neoplasms	CO FA	11400119 15375219

About this table

Genatlas disease: BRCA2

familial breast carcinoma,2,with a high incidence of male breast cancer,sporadic or familial,and

of laryngeal,prostate,ovarian carcinomas (see TSG13D)

GeneTests: BRCA2

Fanconi Anemia

Human Gene Mutation Database: BRCA2
Genetic Association Database: BRCA2
Human Genome Epidemiology Navigator: BRCA2 (522 documents)
Tumor Gene Database: BRCA2
Breast Cancer Gene Database: BRCA2

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1392 PubMed articles for BRCA2 gene (see all 1392 ):

Association of biallelic BRCA2/FANCD1 mutations with spontaneous chromosomal instability and solid tumors of childhood. (PubMed id 14670928)^{3, 4, 6} Hirsch B.... D'Andrea A.D. (2004)
Contribution of germline mutations in BRCA2, P16(INK4A), P14(ARF) and P15 to uveal melanoma. (PubMed id 12556369)^{3, 4, 6} Hearle N.... Houlston R.S. (2003)
A common variant in BRCA2 is associated with both breast cancer risk and prenatal viability. (PubMed id 11062481)^{3, 4, 6} Healey C.S.... Ponder B.A.J. (2000)
Somatic mutations in the BRCA2 gene and high frequency of allelic loss of BRCA2 in sporadic male breast cancer. (PubMed id 11948477)^{1, 3, 4} Kwiatkowska E.... Mackiewicz A. (2002)
Novel germline mutations in the BRCA1 and BRCA2 genes in Indian breast and breast-ovarian cancer families. (PubMed id 14722926)^{1, 3, 4} Valarmathi M.T.... Das S.N. (2004)
Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin. (PubMed id 15199141)^{1, 3, 4} Wang X.Z.... D'Andrea A.D. (2004)
BRCA2 germline mutations in familial pancreatic carcinoma. (PubMed id 12569143)^{1, 3, 4} Hahn S.A....Bartsch D.K. (2003)
A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes. (PubMed id 11857015)^{1, 3, 6} Antoniou A.C....Easton D.F. (2002)
[Mutational analysis of BRCA1 and BRCA2 genes in early-onset breast cancer patients in Shanghai] (PubMed id 16324400)^{1, 3, 6} Song C.G....Shao Z.M. (2005)
Mutations of the BRCA2 gene in ovarian carcinomas. (PubMed id 8665505)^{1, 3, 4} Takahashi H.... Boyd J. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 675	HGNC: 1101	AceView: BRCA2	Ensembl:ENSG00000139618	euGenes: HUgn675
ECgene: BRCA2	H-InvDB: BRCA2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for BRCA2	Genetics and Cytogenetics in Oncology and Haematology
Fanconi Anemia Mutation Database	http://www.rockefeller.edu/fanconi/mutate/jumpd1.html
GeneReviews	http://www.genetests.org/query?gene=BRCA2
NIEHS-SNPs	http://egp.gs.washington.edu/data/brca2/
Wikipedia	http://en.wikipedia.org/wiki/BRCA2

Licensable Technologies for BRCA2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for BRCA2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for BRCA2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for BRCA2		Antibodies for BRCA2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for BRCA2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (BRCA2)
	Antibodies (BRCA2)
	Chimera RNAi (BRCA2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (BRCA2)
	Antibodies (BRCA2)

Search OriGene for BRCA2

Search Tocris compounds for BRCA2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for BRCA2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
BRCA2 Gene at Home site.
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BRCA2 Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for BRCA2

Summaries
for BRCA2

Genomic Location
for BRCA2

Proteins
for BRCA2

Protein Domains/
Families
for BRCA2

Gene Function
for BRCA2

Pathways & Interactions
for BRCA2

Drugs & Compounds
for BRCA2

Transcripts
for BRCA2

Expression
for BRCA2

Orthologs
for BRCA2

Paralogs
for BRCA2

SNPs/Variants
for BRCA2

Disorders & Mutations
for BRCA2

Medical News
for BRCA2

Publications
for BRCA2

Search for BRCA2

Genome Databases showing BRCA2

Other Databases showing BRCA2

Specialized Databases showing BRCA2

Licensable Technologies
for BRCA2

Services
for BRCA2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BRCA2 Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor BRCA2

Summariesfor BRCA2

Genomic Locationfor BRCA2

Proteinsfor BRCA2

Protein Domains/Familiesfor BRCA2

Gene Functionfor BRCA2

Pathways & Interactionsfor BRCA2

Drugs & Compoundsfor BRCA2

Transcriptsfor BRCA2

Expression for BRCA2

Orthologsfor BRCA2

Paralogsfor BRCA2

SNPs/Variantsfor BRCA2

Disorders & Mutationsfor BRCA2

Medical Newsfor BRCA2

Publicationsfor BRCA2

Search for BRCA2

Genome Databases showing BRCA2

Other Databases showing BRCA2

Specialized Databases showing BRCA2

Licensable Technologiesfor BRCA2

Servicesfor BRCA2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BRCA2

Summaries
for BRCA2

Genomic Location
for BRCA2

Proteins
for BRCA2

Protein Domains/
Families
for BRCA2

Gene Function
for BRCA2

Pathways & Interactions
for BRCA2

Drugs & Compounds
for BRCA2

Transcripts
for BRCA2

Expression
for BRCA2

Orthologs
for BRCA2

Paralogs
for BRCA2

SNPs/Variants
for BRCA2

Disorders & Mutations
for BRCA2

Medical News
for BRCA2

Publications
for BRCA2

Licensable Technologies
for BRCA2

Services
for BRCA2