FAN1 Gene
protein-coding GIFtS: 50
GCID: GC15P031197
|
|
FANCD2/FANCI-associated nuclease 1(Previous names: KIAA1018, myotubularin related protein 15 )
(Previous symbols: KIAA1018, MTMR15)
| |
Aliases
for FAN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| FANCD2/FANCI-Associated Nuclease 11 2 3 | | Coiled-Coil Domain-Containing Protein MTMR152 | | KIAA10181 2 3 | | Fanconi Anemia Associated Nuclease 12 | | MTMR151 2 3 | | Fanconi-Associated Nuclease 12 | | Myotubularin-Related Protein 152 3 | | EC 3.1.21.-3 | | Myotubularin Related Protein 151 | | EC 3.1.4.13 | | KMIN2 | | |
Export aliases for FAN1 gene to outside databasesPrevious GC identifer: GC15P008373 |
Summaries
for FAN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FAN1:
This gene encodes a member of the myotubularin-related class 1 cysteine-based protein tyrosine phosphatases. Theencoded protein may be catalytically inactive. Alternatively spliced transcript variants have been described.(provided by RefSeq, Apr 2009)
UniProtKB/Swiss-Prot: FAN1_HUMAN, Q9Y2M0Function: Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrandcross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved inrepair of ICL-induced DNA breaks by being required for efficient homologous recombination, possibly in the resolutionof homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonucleaseactivity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap-specific enzymes to unhookthe ICL by cleaving the lagging-strand template
|
Genomic Views
for FAN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for FAN1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAN1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAN1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q13.2-q13.3 Ensembl cytogenetic band: 15q13.2 HGNC cytogenetic band: 15q13.2-q13.3FAN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P031197: view genomic region
(about GC identifiers)
Start:
|
31,196,055 bp from pter |
End:
|
31,235,311 bp from pter |
Size:
|
39,257 bases |
Orientation:
|
plus strand |
|
Proteins
for FAN1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FAN1_HUMAN, Q9Y2M0 (See
protein sequence)Recommended Name: Fanconi-associated nuclease 1 Size: 1017 amino acids; 114225 Da
Cofactor: Divalent metal cations. Mg(2+) is the most probable
Subunit: Interacts with FANCD2 (when monoubiquitinated). Interacts with FANCI, MLH1, MLH3 and PMS2
Subcellular location: Nucleus. Note=Localizes at sites of DNA damage following recruitment by monoubiquitinated FANCD2
Sequence caution: Sequence=AAH47882.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAA76862.3; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8K4M2 Q86WU8Alternative splicing: 2 isoforms: Q9Y2M0-1 Q9Y2M0-2 Explore the universe of human proteins at neXtProt for FAN1: NX_Q9Y2M0
Post-translational modifications:
Ubiquitinated and degraded during mitotic exit by the APC/C-Cdh1 complex1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y2M0
FAN1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001139566.1 NP_001139567.1 NP_001139568.1 NP_055782.3
ENSEMBL proteins: ENSP00000455983 ENSP00000354497 ENSP00000454223 ENSP00000454544 ENSP00000455573 ENSP00000457680
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IDA | -- |
FAN1 for ontologies About GeneDecksing
FAN1 Antibody Products:
Assay Products for FAN1: |
Protein
Domains /
Families
for FAN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAN1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y2M0ProtoNet protein and cluster: Q9Y2M0 1 Blocks protein family: IPB006642 Zn-finger Rad18
UniProtKB/Swiss-Prot: FAN1_HUMAN, Q9Y2M0Domain: The UBZ-type zinc finger specifically binds monoubiquitinated FANCD2Domain: The KEN box and D-box are required for interaction with FZR1/CDH1 and essential for APC(CDH1)-mediatedubiquitinationSimilarity: Belongs to the FAN1 familySimilarity: Contains 1 UBZ-type zinc fingerSimilarity: Contains 1 VRR-NUC domain |
Function
for FAN1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FAN1_HUMAN, Q9Y2M0Function: Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrandcross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved inrepair of ICL-induced DNA breaks by being required for efficient homologous recombination, possibly in the resolutionof homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonucleaseactivity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap-specific enzymes to unhookthe ICL by cleaving the lagging-strand templateCatalytic activity: Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of3'-hydroxy-terminated oligonucleotidesEnzyme Numbers (IUBMB): EC 3.1.4.11 EC 3.1.21.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAN1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAN1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for FAN1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAN1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAN1 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
FAN1 for ontologies About GeneDecksing
|
Pathways & Interactions
for FAN1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAN1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 18)
5/19 Interacting proteins for FAN1 (Q9Y2M03 ENSP000003544974) via UniProtKB, MINT, STRING, and/or I2D (see all 19)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000724 | double-strand break repair via homologous recombination |
IMP | -- | | GO:0006281 | DNA repair |
IMP | -- | | GO:0006289 | nucleotide-excision repair |
IMP | -- | | GO:0033683 | nucleotide-excision repair, DNA incision |
IMP | -- |
FAN1 for ontologies About GeneDecksing
|
Drugs & Compounds
for FAN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAN1
Search CenterWatch for drugs/clinical trials and news about FAN1
|
Transcripts
for FAN1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAN1 gene (4 alternative transcripts): NM_001146094.1 NM_001146095.1 NM_001146096.1 NM_014967.4 Unigene Cluster for FAN1: FANCD2/FANCI-associated nuclease 1 Hs.584863 [show with all ESTs]Unigene Representative Sequence: CR9367278 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000561594(uc001zfc.3 uc010azw.2 uc001zfd.3) ENST00000362065(uc001zff.3)
ENST00000561607 ENST00000565466 ENST00000565280(uc001zfe.3) ENST00000562892
ENST00000568145 ENST00000562881
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAN1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAN1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): FAN1 (NM_014967) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAN1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAN1 |
Additional cDNA sequence: AB023235.2 AK290987.1 BC044890.1 BC047882.1 BX647391.1 CR936727.1 CR936734.1 HM560957.1 11 DOTS entries: DT.215209 DT.99992948 DT.99943434 DT.97792107 DT.423290 DT.75192767 DT.100787266 DT.91755075 DT.121027730 DT.75172392 DT.75100939 24/142 AceView cDNA sequences (see all 142): AA323109 CR596971 AI985586 AA923587 BC044890 BM313858 AI859495 AL708291 CB157853 BQ945686 BM689473 CB161773 CB164601 AL528776 CD644036 CB156850 AI453577 CK905207 BE873144 AA369778 AA383430 BX282319 AI861820 BX348734
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FAN1 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FAN1
|
Expression
for FAN1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTACATCAC
About this image
See FAN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAN1
SOURCE GeneReport for Unigene cluster: Hs.584863
SABiosciences Custom PCR Arrays for FAN1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAN1
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAN1 |
Orthologs
for FAN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for FAN1 gene from 8/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Fan11 , 5 |
FANCD2/FANCI-associated nuclease 11, 5 |
78.82(n)1
73.21(a)1 |
|
7 (34.64 cM)5
3305541 NM_177893.31 NP_808561.21
643467585 |
chicken
(Gallus gallus) |
Aves |
FAN11 |
FANCD2/FANCI-associated nuclease 1 |
61.87(n)
57.3(a) |
|
415383 XM_413768.2 XP_413768.2 |
lizard
(Anolis carolinensis) |
Reptilia |
FAN16 |
-- |
49(a) |
1 ↔ 1 |
GL343428.1(33217-46795) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
1377295312 |
-- |
73.51(n) |
|
137729531 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufd06a072 |
Transcribed sequence with weak similarity to protein more |
70.78(n) |
|
57054874 |
worm
(Caenorhabditis elegans) |
Secernentea |
fan-11 |
Protein FAN-1 |
42.25(n)
30.75(a) |
|
177415 NM_068596.3 NP_500997.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G483606 |
fanconi-associated nuclease 1-like protein |
23(a) |
1 ↔ 1 |
1(17868650-17873032) |
rice
(Oryza sativa) |
Liliopsida |
-- |
HIRAN domain containing protein, putative, express... |
23(a) |
1 ↔ 1 |
6(3597465-3604189) |
ENSEMBL Gene Tree for FAN1 (if available)
TreeFam Gene Tree for FAN1 (if available) |
Paralogs
for FAN1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for FAN1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAN1 (31196055 - 31235311 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAN1: --
Human Gene Mutation Database (HGMD): FAN1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAN1 |
|
Disorders
/ Diseases
for FAN1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAN1 for disorders About GeneDecksing
OMIM gene information: 613534
OMIM disorders: --
UniProtKB/Swiss-Prot: FAN1_HUMAN, Q9Y2M0
Defects in FAN1 are the cause of interstitial nephritis, karyomegalic (KMIN) [MIM:614817]. A rare kidneydisease characterized by chronic tubulointerstitial nephritis associated with massively enlarged tubular epithelialcell nuclei. The clinical picture is associated with recurrent upper respiratory tract infections in addition tochronic kidney disease beginning in the third decade of life
2  diseases for FAN1: About MalaCardsfanconi's anemia anemia
1 disease from the University of Copenhagen DISEASES database for FAN1:Fanconi's anemia Export disorders for FAN1 gene to outside databases
|
Publications
for FAN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAN1 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with FAN1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A genetic screen identifies FAN1, a Fanconi anemia-as sociated nuclease necessary for DNA interstrand crosslink repair. (PubMed id 20603073)1, 2, 3 Smogorzewska A....Elledge S.J. (2010)
- Identification of KIAA1018/FAN1, a DNA repair nucleas e recruited to DNA damage by monoubiquitinated FANCD2. (PubMed id 20603015)1, 2, 3 MacKay C....Rouse J. (2010)
- Deficiency of FANCD2-associated nuclease KIAA1018/FAN 1 sensitizes cells to interstrand crosslinking agents. (PubMed id 20603016)1, 2, 3 Kratz K....Jiricny J. (2010)
- FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair. (PubMed id 22772369)1, 2 Zhou W....Hildebrandt F. (2012)
- FAN1 acts with FANCI-FANCD2 to promote DNA interstran d cross-link repair. (PubMed id 20671156)1, 2 Liu T....Huang J. (2010)
- Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (1999)
- On the role of FAN1 in Fanconi anemia. (PubMed id 22611161)1 Trujillo J.P....Surralles J. (2012)
- Human KIAA1018/FAN1 nuclease is a new mitotic substrate of APC/C(Cdh1). (PubMed id 22854063)2 Lai F.... Kang T. (2012)
- FAN1 variants identified in multiple-case early-onset breast cancer families via exome sequencing: no evidence for association with ri sk for breast cancer. (PubMed id 21858661)1 Park D.J....Southey M.C. (2011)
- Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
|
External Searches for FAN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAN1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing FAN1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAN1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAN1 gene:
Search GeneIP for patents involving FAN1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAN1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | Browse OriGene 29mer shRNA kits in GFP-retroviral vector | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAN1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAN1 | | OriGene 3'-UTR Clone for FAN1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAN1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAN1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAN1 | | OriGene Custom Protein Services for FAN1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAN1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAN1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAN1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAN1 |
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| | | | Search Tocris compounds for FAN1 |
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 | | | FAN1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAN1 |
|  |  |  | | | | ThermoFisher Antibodies for FAN1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAN1 |
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