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Aliases for FAM9C Gene

Aliases for FAM9C Gene

  • Family With Sequence Similarity 9, Member C 2 3
  • Testis Expressed 39C 2 3
  • Protein FAM9C 3
  • TEX39C 3

External Ids for FAM9C Gene

Summaries for FAM9C Gene

Entrez Gene Summary for FAM9C Gene

  • This gene is a member of a gene family which arose through duplication on the X chromosome. The encoded protein may be localized to the nucleus as the protein contains several nuclear localization signals, and has similarity to a synaptonemal complex protein. [provided by RefSeq, Aug 2011]

GeneCards Summary for FAM9C Gene

FAM9C (Family With Sequence Similarity 9, Member C) is a Protein Coding gene. An important paralog of this gene is FAM9B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM9C Gene

Genomics for FAM9C Gene

Genomic Location for FAM9C Gene

Start:
13,035,617 bp from pter
End:
13,044,798 bp from pter
Size:
9,182 bases
Orientation:
Minus strand

Genomic View for FAM9C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM9C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM9C Gene

No data available for Regulatory Elements for FAM9C Gene

Proteins for FAM9C Gene

  • Protein details for FAM9C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZT9-FAM9C_HUMAN
    Recommended name:
    Protein FAM9C
    Protein Accession:
    Q8IZT9
    Secondary Accessions:
    • B2R9G7
    • Q5HYJ6

    Protein attributes for FAM9C Gene

    Size:
    166 amino acids
    Molecular mass:
    19210 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM9C Gene

Proteomics data for FAM9C Gene at MOPED

Post-translational modifications for FAM9C Gene

No Post-translational modifications

Other Protein References for FAM9C Gene

No data available for DME Specific Peptides for FAM9C Gene

Domains for FAM9C Gene

Protein Domains for FAM9C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM9C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZT9

UniProtKB/Swiss-Prot:

FAM9C_HUMAN
Family:
  • Belongs to the FAM9 family.:
    • Q8IZT9
genes like me logo Genes that share domains with FAM9C: view

No data available for Gene Families for FAM9C Gene

Function for FAM9C Gene

Gene Ontology (GO) - Molecular Function for FAM9C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM9C: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FAM9C Gene

Localization for FAM9C Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM9C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM9C Gene COMPARTMENTS Subcellular localization image for FAM9C gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for FAM9C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with FAM9C: view

Pathways for FAM9C Gene

SuperPathways for FAM9C Gene

No Data Available

Interacting Proteins for FAM9C Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000334430%0d%0a9606.ENSP00000357516%0d%0a
Selected Interacting proteins: ENSP00000334430 Q8IZT9-FAM9C_HUMAN for FAM9C Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for FAM9C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007286 spermatid development IBA --
genes like me logo Genes that share ontologies with FAM9C: view

No data available for Pathways by source for FAM9C Gene

Transcripts for FAM9C Gene

mRNA/cDNA for FAM9C Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM9C Gene

Family with sequence similarity 9, member C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM9C Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1: - -
SP2:

Relevant External Links for FAM9C Gene

GeneLoc Exon Structure for
FAM9C
ECgene alternative splicing isoforms for
FAM9C

Expression for FAM9C Gene

mRNA expression in normal human tissues for FAM9C Gene

mRNA differential expression in normal tissues according to GTEx for FAM9C Gene

This gene is overexpressed in Spleen (34.4) and Testis (6.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FAM9C Gene

SOURCE GeneReport for Unigene cluster for FAM9C Gene Hs.667546

mRNA Expression by UniProt/SwissProt for FAM9C Gene

Q8IZT9-FAM9C_HUMAN
Tissue specificity: Expressed exclusively in testis.
genes like me logo Genes that share expressions with FAM9C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FAM9C Gene

Orthologs for FAM9C Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for FAM9C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 36 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
FAM9C 35
  • 99.4 (n)
  • 98.19 (a)
Species with no ortholog for FAM9C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM9C Gene

ENSEMBL:
Gene Tree for FAM9C (if available)
TreeFam:
Gene Tree for FAM9C (if available)

Paralogs for FAM9C Gene

Paralogs for FAM9C Gene

Selected SIMAP similar genes for FAM9C Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for FAM9C Gene

genes like me logo Genes that share paralogs with FAM9C: view

Variants for FAM9C Gene

Sequence variations from dbSNP and Humsavar for FAM9C Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs878774 -- 13,046,544(+) TGGAG(C/T)ATTTG upstream-variant-2KB
rs1003374 -- 13,045,231(-) aaaaa(A/G)aaaga upstream-variant-2KB
rs1634324 -- 13,044,597(-) GAGGA(G/T)CTTCG utr-variant-5-prime, upstream-variant-2KB
rs1984539 -- 13,041,907(-) AAAAT(G/T)TGTAT intron-variant
rs2016060 -- 13,041,660(-) AAATA(C/T)AGTTA intron-variant

Relevant External Links for FAM9C Gene

HapMap Linkage Disequilibrium report
FAM9C
Human Gene Mutation Database (HGMD)
FAM9C
Locus Specific Mutation Databases (LSDB)
FAM9C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM9C Gene

Disorders for FAM9C Gene

Relevant External Links for FAM9C

Genetic Association Database (GAD)
FAM9C
genes like me logo Genes that share disorders with FAM9C: view

No data available for UniProtKB/Swiss-Prot for FAM9C Gene

Publications for FAM9C Gene

  1. A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed exclusively in testis: implications for recombinations in this region. (PMID: 12213195) Martinez-Garay I. … Kutsche K. (Genomics 2002) 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. FAM9C plays an anti-apoptotic role through activation of the PI3K/Akt pathway in human hepatocellular carcinoma. (PMID: 23836295) Zhou J.D. … Wu J.C. (Oncol. Rep. 2013) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for FAM9C Gene

Sources for FAM9C Gene

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