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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM9C Gene

protein-coding   GIFtS: 40
GCID: GC0XM013053

Family With Sequence Similarity 9, Member C

  Search for FAM9C
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 9, Member C1 2
Testis Expressed 39C1 2
TEX39C2
Protein FAM9C2

External Ids:    HGNC: 184051   Entrez Gene: 1714842   Ensembl: ENSG000001872687   OMIM: 3004795   UniProtKB: Q8IZT93   

Export aliases for FAM9C gene to outside databases

Previous GC identifers: GC0XU990386 GC0XM012415 GC0XM012813 GC0XP011142 GC0XM012964 GC0XM010816


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FAM9C Gene:
This gene is a member of a gene family which arose through duplication on the X chromosome. The encoded protein
may be localized to the nucleus as the protein contains several nuclear localization signals, and has similarity
to a synaptonemal complex protein. (provided by RefSeq, Aug 2011)

GeneCards Summary for FAM9C Gene: 
FAM9C (family with sequence similarity 9, member C) is a protein-coding gene. An important paralog of this gene is FAM9A.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_167197.1  NC_018934.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for FAM9C
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM9C promoter sequence
   Search SABiosciences Chromatin IP Primers for FAM9C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM9C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.2   Ensembl cytogenetic band:  Xp22.2   HGNC cytogenetic band: Xp22.32

FAM9C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM9C gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM013053:  view genomic region     (about GC identifiers)

Start:
13,053,736 bp from pter      End:
13,062,917 bp from pter
Size:
9,182 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FAM9C_HUMAN, Q8IZT9 (See protein sequence)
Recommended Name: Protein FAM9C  
Size: 166 amino acids; 19210 Da
Subcellular location: Nucleus
Secondary accessions: B2R9G7 Q5HYJ6

Explore the universe of human proteins at neXtProt for FAM9C: NX_Q8IZT9

Explore proteomics data for FAM9C at MOPED 

FAM9C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

FAM9C Protein Expression

REFSEQ proteins: NP_777561.1  
ENSEMBL proteins: 
 ENSP00000369999   ENSP00000334430   ENSP00000409506   ENSP00000439185  

Human Recombinant Protein Products for FAM9C: 
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

FAM9C for ontologies           About GeneDecksing



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Cloud-Clone Corp. CLIAs for FAM9C


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR006888 Cor1/Xlr/Xmr

Graphical View of Domain Structure for InterPro Entry Q8IZT9

ProtoNet protein and cluster: Q8IZT9

UniProtKB/Swiss-Prot: FAM9C_HUMAN, Q8IZT9
Similarity: Belongs to the FAM9 family


FAM9C for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM9C 
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM9C

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM9C

Search CenterWatch for drugs/clinical trials and news about FAM9C

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FAM9C gene: 
NM_174901.5  

Unigene Cluster for FAM9C:

Family with sequence similarity 9, member C
Hs.667546  [show with all ESTs]
Unigene Representative Sequence: BX647580
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000380625 ENST00000468287 ENST00000333995 ENST00000438997 ENST00000542843(uc004cvh.2 uc004cvg.3)

miRNA
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Inhib. RNA
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Additional mRNA sequence: 

AF494345.1 AK313776.1 BC127957.1 BX647580.1 

3 DOTS entries:

DT.100009610  DT.101980527  DT.95209370 

11 AceView cDNA sequences:

BX648111 AI214289 BM832944 BX648919 BI521529 BX647580 BQ081938 AI969041 
AI650599 BI522314 AW444496 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for FAM9C    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1:        -                       -                           
SP2:                                                            


ECgene alternative splicing isoforms for FAM9C

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM9C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
FAM9C Expression
About this image


See FAM9C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM9C

SOURCE GeneReport for Unigene cluster: Hs.667546

UniProtKB/Swiss-Prot: FAM9C_HUMAN, Q8IZT9
Tissue specificity: Expressed exclusively in testis

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM9C

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and chimp.

Orthologs for FAM9C gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia FAM9C1 family with sequence similarity 9, member C 99.4(n)
98.19(a)
  735851  XM_001135435.2  XP_001135435.2 


ENSEMBL Gene Tree for FAM9C (if available)
TreeFam Gene Tree for FAM9C (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for FAM9C gene
FAM9A2  FAM9B2  
3 SIMAP similar genes for FAM9C using alignment to 3 protein entries:     FAM9C_HUMAN (see all proteins):
DKFZp686B0429    FAM9A    FAM9B

FAM9C for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for FAM9C
PGOHUM00000260945 PGOHUM00000261037


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/211 SNPs in FAM9C are shown (see all 211)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1435331361,2
C--12968659(+) TAACAA/GCTGCA 1 -- ds50010--------
rs1861525581,2
--12969123(+) ATGCAC/GAGATA 1 -- ds50010--------
rs1918982031,2
--12969267(+) GACTGC/TGTATG 1 -- ut310--------
rs1467541131,2
--12969527(+) CTCTTA/GCTGCA 1 -- ut310--------
rs98872201,2
C,F,H--12969565(+) ATTGCG/AATACA 1 -- int1 ese39Minor allele frequency- A:0.13NS EA NA 1198
rs1817160911,2
--12969606(+) ACATCA/GATCCT 1 -- int10--------
rs669310311,2
--12970312(+) CAAAT-/ATGCACG 1 -- int10--------
rs1499188021,2
--12970488(+) AGCATC/GAGAGT 1 -- int10--------
rs59797921,2
C,F,H--12970535(+) AGAGGC/TGGGAA 1 -- int1 ese38Minor allele frequency- T:0.16NS EA NA 1178
rs1138208651,2
C,F--12970536(+) GAGGCG/AGGAAG 1 -- int11Minor allele frequency- A:0.50WA 2

HapMap Linkage Disequilibrium report for FAM9C (13053736 - 13062917 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for FAM9C: --

Human Gene Mutation Database (HGMD): FAM9C

Locus Specific Mutation Databases (LSDB): FAM9C
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing FAM9C
DNA2.0 Custom Variant and Variant Library Synthesis for FAM9C

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FAM9C for disorders           About MalaCards
OMIM gene information: 300479    OMIM disorders: --


FAM9C for disorders           About GeneDecksing

Genetic Association Database (GAD): FAM9C

Export disorders for FAM9C gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for FAM9C gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM9C)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed exclusively in testis: implications for recombinations in this region. (PubMed id 12213195)1, 2, 9 Martinez-Garay I....Kutsche K. (2002)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. FAM9C plays an anti-apoptotic role through activation of the PI3K/Akt pathway in human hepatocellular carcinoma. (PubMed id 23836295)1 Zhou J.D....Wu J.C. (2013)
  4. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)
  5. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (2007)
  6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
  7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 171484 HGNC: 18405 AceView: FAM9C Ensembl:ENSG00000187268 euGenes: HUgn171484
ECgene: FAM9C H-InvDB: FAM9C

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for FAM9C Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for FAM9C gene:
Search GeneIP for patents involving FAM9C

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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 Proteins for FAM9C
 Antibodies for FAM9C
 ELISAs for FAM9C
 CLIAs for FAM9C
 Search LifeMap BioReagents cell lines for FAM9C
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM9C
 SwitchGear 3'UTR luciferase reporter plasmids for FAM9C
 SwitchGear Promoter luciferase reporter plasmids for FAM9C
 Search ThermoFisher Antibodies for FAM9C
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM9C
 inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM9C
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FAM9C
Customized:
 lentivirus for stable overexpression of FAM9C
 lentivirus expression plasmids for stable overexpression of FAM9C
 adenovirus for overexpression of FAM9C
 Search LSBio for Antibodies for FAM9C
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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