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Aliases for FAM9C Gene

Aliases for FAM9C Gene

  • Family With Sequence Similarity 9 Member C 2 3 5
  • Testis Expressed 39C 2 3
  • Family With Sequence Similarity 9, Member C 2
  • Protein FAM9C 3
  • TEX39C 3

External Ids for FAM9C Gene

Previous GeneCards Identifiers for FAM9C Gene

  • GC0XU990386
  • GC0XM012415
  • GC0XM012813
  • GC0XP011142
  • GC0XM012964
  • GC0XM010816

Summaries for FAM9C Gene

Entrez Gene Summary for FAM9C Gene

  • This gene is a member of a gene family which arose through duplication on the X chromosome. The encoded protein may be localized to the nucleus as the protein contains several nuclear localization signals, and has similarity to a synaptonemal complex protein. [provided by RefSeq, Aug 2011]

GeneCards Summary for FAM9C Gene

FAM9C (Family With Sequence Similarity 9 Member C) is a Protein Coding gene. An important paralog of this gene is FAM9A.

Additional gene information for FAM9C Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM9C Gene

Genomics for FAM9C Gene

GeneHancer (GH) Regulatory Elements for FAM9C Gene

Promoters and enhancers for FAM9C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI013045 Promoter 0.6 EPDnew 587.6 +0.2 175 0.1 ZBTB33 FAM9C LOC105373133
GH0XI013044 Promoter 0.5 EPDnew 550.8 +0.4 438 0.1 LOC105373133 FAM9C TMSB4X
GH0XI013046 Enhancer 0.3 Ensembl 594.7 -1.7 -1703 0.2 RUNX3 FAM9C LOC105373133 PIR38604
GH0XI013073 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 59.4 -40.3 -40279 22.6 HDGF PKNOX1 ATF1 SMAD1 YBX1 IRF4 ZNF121 ZNF766 ZNF207 ZNF143 FAM9C TMSB4X TLR8 TLR7 ENSG00000261030 PIR38604 LOC105373133
GH0XI013012 Enhancer 1.2 Ensembl ENCODE dbSUPER 47.1 +29.7 29667 4.3 HDGF ELF3 BATF RAD21 ATF7 ETV6 FOS BCLAF1 IKZF2 SMARCC1 FAM9C TMSB4X LOC105373133
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM9C on UCSC Golden Path with GeneCards custom track

Genomic Locations for FAM9C Gene

Genomic Locations for FAM9C Gene
chrX:13,035,617-13,044,798
(GRCh38/hg38)
Size:
9,182 bases
Orientation:
Minus strand
chrX:13,053,736-13,062,917
(GRCh37/hg19)

Genomic View for FAM9C Gene

Genes around FAM9C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM9C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM9C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM9C Gene

Proteins for FAM9C Gene

  • Protein details for FAM9C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZT9-FAM9C_HUMAN
    Recommended name:
    Protein FAM9C
    Protein Accession:
    Q8IZT9
    Secondary Accessions:
    • B2R9G7
    • Q5HYJ6

    Protein attributes for FAM9C Gene

    Size:
    166 amino acids
    Molecular mass:
    19210 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM9C Gene

Post-translational modifications for FAM9C Gene

No Post-translational modifications

Other Protein References for FAM9C Gene

No data available for DME Specific Peptides for FAM9C Gene

Domains & Families for FAM9C Gene

Gene Families for FAM9C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FAM9C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM9C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZT9

UniProtKB/Swiss-Prot:

FAM9C_HUMAN :
  • Belongs to the FAM9 family.
Family:
  • Belongs to the FAM9 family.
genes like me logo Genes that share domains with FAM9C: view

Function for FAM9C Gene

Gene Ontology (GO) - Molecular Function for FAM9C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM9C: view
genes like me logo Genes that share phenotypes with FAM9C: view

miRNA for FAM9C Gene

miRTarBase miRNAs that target FAM9C

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM9C Gene

Localization for FAM9C Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM9C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM9C gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for FAM9C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000800 lateral element IBA --
GO:0005634 nucleus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM9C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FAM9C Gene

Pathways & Interactions for FAM9C Gene

SuperPathways for FAM9C Gene

No Data Available

Interacting Proteins for FAM9C Gene

Gene Ontology (GO) - Biological Process for FAM9C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051321 meiotic cell cycle IBA --
genes like me logo Genes that share ontologies with FAM9C: view

No data available for Pathways by source and SIGNOR curated interactions for FAM9C Gene

Drugs & Compounds for FAM9C Gene

No Compound Related Data Available

Transcripts for FAM9C Gene

mRNA/cDNA for FAM9C Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM9C Gene

Family with sequence similarity 9, member C:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM9C Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1: - -
SP2:

Relevant External Links for FAM9C Gene

GeneLoc Exon Structure for
FAM9C
ECgene alternative splicing isoforms for
FAM9C

Expression for FAM9C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM9C Gene

mRNA differential expression in normal tissues according to GTEx for FAM9C Gene

This gene is overexpressed in Spleen (x34.4) and Testis (x6.6).

Protein differential expression in normal tissues from HIPED for FAM9C Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM9C Gene



Protein tissue co-expression partners for FAM9C Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM9C Gene:

FAM9C

SOURCE GeneReport for Unigene cluster for FAM9C Gene:

Hs.667546

mRNA Expression by UniProt/SwissProt for FAM9C Gene:

Q8IZT9-FAM9C_HUMAN
Tissue specificity: Expressed exclusively in testis.

Evidence on tissue expression from TISSUES for FAM9C Gene

  • Heart(4)
genes like me logo Genes that share expression patterns with FAM9C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM9C Gene

Orthologs for FAM9C Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for FAM9C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM9C 33
  • 99.4 (n)
-- 34
  • 98 (a)
OneToMany
-- 34
  • 36 (a)
OneToMany
Species where no ortholog for FAM9C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM9C Gene

ENSEMBL:
Gene Tree for FAM9C (if available)
TreeFam:
Gene Tree for FAM9C (if available)

Paralogs for FAM9C Gene

Paralogs for FAM9C Gene

(3) SIMAP similar genes for FAM9C Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for FAM9C Gene

genes like me logo Genes that share paralogs with FAM9C: view

Variants for FAM9C Gene

Sequence variations from dbSNP and Humsavar for FAM9C Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1057522761 likely-benign, not specified 13,042,959(-) A/G intron_variant
rs1001940813 -- 13,035,202(-) T/C downstream_transcript_variant
rs1002288798 -- 13,044,986(-) C/T upstream_transcript_variant
rs1002360695 -- 13,044,560(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1003205845 -- 13,038,430(-) C/T 3_prime_UTR_variant

Variation tolerance for FAM9C Gene

Residual Variation Intolerance Score: 71.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM9C Gene

Human Gene Mutation Database (HGMD)
FAM9C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM9C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM9C Gene

Disorders for FAM9C Gene

Additional Disease Information for FAM9C

No disorders were found for FAM9C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM9C Gene

Publications for FAM9C Gene

  1. A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed exclusively in testis: implications for recombinations in this region. (PMID: 12213195) Martinez-Garay I … Kutsche K (Genomics 2002) 3 4 22 58
  2. FAM9C plays an anti-apoptotic role through activation of the PI3K/Akt pathway in human hepatocellular carcinoma. (PMID: 23836295) Zhou JD … Wu JC (Oncology reports 2013) 2 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58

Products for FAM9C Gene

Sources for FAM9C Gene

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