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FAM9B Gene(Protein Coding)

Family With Sequence Similarity 9 Member B

GCID:
GC0XM008952
GIFtS:
46
Genes Participants
UDN Logo

Aliases for FAM9B Gene

Aliases for FAM9B Gene

  • Family With Sequence Similarity 9 Member B 2 3 5
  • Testis Expressed 39B 2 3
  • Family With Sequence Similarity 9, Member B 2
  • Protein FAM9B 3
  • TEX39B 3

External Ids for FAM9B Gene

Previous GeneCards Identifiers for FAM9B Gene

  • GC0XU990385
  • GC0XM008802
  • GC0XM006820

Summaries for FAM9B Gene

Entrez Gene Summary for FAM9B Gene

  • This gene is a member of a gene family which arose through duplication on the X chromosome. The encoded protein may be localized to the nucleus as the protein contains several nuclear localization signals, and has similarity to a synaptonemal complex protein. [provided by RefSeq, Aug 2011]

GeneCards Summary for FAM9B Gene

FAM9B (Family With Sequence Similarity 9 Member B) is a Protein Coding gene. An important paralog of this gene is FAM9A.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM9B Gene

Genomics for FAM9B Gene

Products:

  1. Regulatory Element

Regulatory Elements for FAM9B Gene

Enhancers for FAM9B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG009314 0.8 Ensembl ENCODE 30.8 -119.2 -119186 3.0 CEBPB JUNB ETV6 FOS FAM9B TBL1X ENSG00000228543 LOC442443
GH0XG009327 0.6 ENCODE 24.9 -130.6 -130637 0.2 JUN CEBPB MBD2 GATA3 JUND CUX1 FOS SETDB1 FAM9B LOC442443 ENSG00000228543
GH0XG009339 1.5 FANTOM5 Ensembl ENCODE 9.3 -144.2 -144240 3.8 ATF1 ARNT KLF13 DEK ZNF263 JUNB REST TBX21 ZNF592 SMARCA4 TBL1X FAM9B LOC442443 ENSG00000228543
GH0XG009378 1 Ensembl ENCODE 12.9 -182.5 -182537 1.7 SOX5 STAT1 NFIB JUN CEBPB CEBPG EP300 NFIC JUND STAT3 FAM9B LOC442443 ENSG00000228543
GH0XG009350 1.5 FANTOM5 Ensembl ENCODE 7.8 -155.0 -154981 3.0 ATF1 SIN3A TCF12 GTF3C2 FOS DEK NCOA1 REST ZNF592 ZNF579 TBL1X FAM9B LOC442443 ENSG00000228543
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM9B on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the FAM9B gene promoter:

Genomic Location for FAM9B Gene

Chromosome:
X
Start:
9,024,232 bp from pter
End:
9,197,249 bp from pter
Size:
173,018 bases
Orientation:
Minus strand

Genomic View for FAM9B Gene

Genes around FAM9B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM9B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM9B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FAM9B Gene

Proteins for FAM9B Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FAM9B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZU0-FAM9B_HUMAN
    Recommended name:
    Protein FAM9B
    Protein Accession:
    Q8IZU0
    Secondary Accessions:
    • Q0IJ68
    • Q8N7Z8

    Protein attributes for FAM9B Gene

    Size:
    186 amino acids
    Molecular mass:
    22438 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM9B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM9B Gene

Post-translational modifications for FAM9B Gene

No Post-translational modifications

Other Protein References for FAM9B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM9B Gene

Domains & Families for FAM9B Gene

Protein Domains for FAM9B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM9B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZU0

UniProtKB/Swiss-Prot:

FAM9B_HUMAN :
  • Belongs to the FAM9 family.
Family:
  • Belongs to the FAM9 family.
genes like me logo Genes that share domains with FAM9B: view

No data available for Gene Families for FAM9B Gene

Function for FAM9B Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Gene Ontology (GO) - Molecular Function for FAM9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM9B: view

Phenotypes for FAM9B Gene

GenomeRNAi human phenotypes for FAM9B:
genes like me logo Genes that share phenotypes with FAM9B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM9B Gene

Localization for FAM9B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM9B Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM9B gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for FAM9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with FAM9B: view

Pathways & Interactions for FAM9B Gene

SuperPathways for FAM9B Gene

PathCards logo More details on SuperPathways for FAM9B
No Data Available

Gene Ontology (GO) - Biological Process for FAM9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007286 spermatid development IBA --
genes like me logo Genes that share ontologies with FAM9B: view

No data available for Pathways by source and SIGNOR curated interactions for FAM9B Gene

Drugs & Compounds for FAM9B Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for FAM9B Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for FAM9B Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM9B Gene

Family with sequence similarity 9, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM9B Gene

No ASD Table

Relevant External Links for FAM9B Gene

GeneLoc Exon Structure for
FAM9B
ECgene alternative splicing isoforms for
FAM9B

Expression for FAM9B Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM9B Gene

mRNA expression in normal human tissues for FAM9B Gene
mRNA expression by GTEx for FAM9B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM9B Gene

This gene is overexpressed in Testis (x18.9), Uterus (x11.7), and Liver (x10.5).

NURSA nuclear receptor signaling pathways regulating expression of FAM9B Gene:

FAM9B

SOURCE GeneReport for Unigene cluster for FAM9B Gene:

Hs.733351

mRNA Expression by UniProt/SwissProt for FAM9B Gene:

Q8IZU0-FAM9B_HUMAN
Tissue specificity: Expressed exclusively in testis.
genes like me logo Genes that share expression patterns with FAM9B: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM9B Gene

Orthologs for FAM9B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for FAM9B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FAM9B 34 35
  • 98.39 (n)
Species where no ortholog for FAM9B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM9B Gene

ENSEMBL:
Gene Tree for FAM9B (if available)
TreeFam:
Gene Tree for FAM9B (if available)

Paralogs for FAM9B Gene

Paralogs for FAM9B Gene

(1) SIMAP similar genes for FAM9B Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for FAM9B Gene

genes like me logo Genes that share paralogs with FAM9B: view

Variants for FAM9B Gene

Sequence variations from dbSNP and Humsavar for FAM9B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000040307 -- 9,119,827(+) GGCCC(-/T)TTTTT intron-variant
rs1000055934 -- 9,044,692(+) AATAT(C/G)GGTTT intron-variant
rs1000080116 -- 9,186,473(+) CCGCC(C/T)GTCCA intron-variant
rs1000104252 -- 9,060,117(+) CTTGC(A/T)TTGAC intron-variant
rs1000111139 -- 9,142,140(+) CTGAG(G/T)CATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM9B Gene

Variant ID Type Subtype PubMed ID
nsv515590 CNV gain 19592680
nsv526672 CNV gain 19592680
nsv6791 CNV insertion 18451855

Variation tolerance for FAM9B Gene

Residual Variation Intolerance Score: 77.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM9B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM9B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM9B Gene

Disorders for FAM9B Gene

Relevant External Links for FAM9B

Genetic Association Database (GAD)
FAM9B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM9B

No disorders were found for FAM9B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM9B Gene

Publications for FAM9B Gene

  1. A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed exclusively in testis: implications for recombinations in this region. (PMID: 12213195) Martinez-Garay I. … Kutsche K. (Genomics 2002) 2 3 4 22 64
  2. Genome-wide association study identifies a new locus JMJD1C at 10q21 that may influence serum androgen levels in men. (PMID: 22936694) Jin G. … Xu J. (Hum. Mol. Genet. 2012) 2 3 64
  3. Genetic determinants of serum testosterone concentrations in men. (PMID: 21998597) Ohlsson C. … Haring R. (PLoS Genet. 2011) 2 3 64
  4. Quantitative reactivity profiling predicts functional cysteines in proteomes. (PMID: 21085121) Weerapana E. … Cravatt B.F. (Nature 2010) 2 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for FAM9B Gene

Sources for FAM9B Gene

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