Aliases for FAM98C Gene
Aliases for FAM98C Gene
External Ids for FAM98C Gene
- HGNC: 27119
- Entrez Gene: 147965
- Ensembl: ENSG00000130244
- UniProtKB: Q17RN3
Previous GeneCards Identifiers for FAM98C Gene
- GC19P043586
- GC19P038893
- GC19P035341
Summaries for FAM98C Gene
GeneCards Summary for FAM98C Gene
FAM98C (Family With Sequence Similarity 98 Member C) is a Protein Coding gene. Diseases associated with FAM98C include Meckel Syndrome 1. An important paralog of this gene is FAM98A.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM98C Gene
Genomics for FAM98C Gene
Regulatory Elements for FAM98C Gene
Enhancers for FAM98C Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FAM98C on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for FAM98C Gene
- Chromosome:
- 19
- Start:
- 38,403,125 bp from pter
- End:
- 38,409,088 bp from pter
- Size:
- 5,964 bases
- Orientation:
- Plus strand
Genomic View for FAM98C Gene
Genes around FAM98C on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.2 by Ensembl
- 19q13.2 by Entrez Gene
- 19q13.2 by HGNC
FAM98C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FAM98C Gene
Proteins for FAM98C Gene
-
Protein details for FAM98C Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q17RN3-FA98C_HUMAN
- Recommended name:
- Protein FAM98C
- Protein Accession:
- Q17RN3
- A6NMW3
- Q66K45
Protein attributes for FAM98C Gene
- Size:
- 349 amino acids
- Molecular mass:
- 37329 Da
- Quaternary structure:
- No Data Available
Protein Expression for FAM98C Gene
Post-translational modifications for FAM98C Gene
Other Protein References for FAM98C Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FAM98C
-
Abcam antibodies for FAM98C
- Invitrogen Antibodies for FAM98C
- Search GeneTex for Antibodies for FAM98C
Protein Products
-
OriGene Purified Proteins for FAM98C
- Search Origene for MassSpec and Protein Over-expression Lysates for FAM98C
- Origene Custom Protein Services for FAM98C
- Search GeneTex for Proteins for FAM98C
Assay Products
No data available for DME Specific Peptides for FAM98C Gene
Domains & Families for FAM98C Gene
Protein Domains for FAM98C Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FAM98C Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q17RN3- Family:
-
- Belongs to the FAM98 family.
No data available for Gene Families for FAM98C Gene
Function for FAM98C Gene
Phenotypes for FAM98C Gene
- GenomeRNAi human phenotypes for FAM98C:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FAM98C gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM98C gene
- Search ViGene Biosciences for FAM98C
CRISPR Products
-
OriGene CRISPR knockouts for FAM98C
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM98C
- GenScript: Design CRISPR guide RNA sequences for FAM98C
miRNA Products
- Search ViGene Biosciences for FAM98C
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FAM98C
- Browse OriGene Inhibitory RNA Products For FAM98C
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM98C gene
Clone Products
-
OriGene ORF clones in human for FAM98C
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for FAM98C
-
ViGene Biosciences adenoviral particle packaged cDNA for FAM98C gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FAM98C gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM98C gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM98C Gene
Localization for FAM98C Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| cytosol | 3 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0072669 | tRNA-splicing ligase complex | IBA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM98C Gene
Pathways & Interactions for FAM98C Gene
No Data Available
Interacting Proteins for FAM98C Gene
No data available for Pathways by source and SIGNOR curated interactions for FAM98C Gene
Transcripts for FAM98C Gene
mRNA/cDNA for FAM98C Gene
- (2) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (99) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FAM98C Gene
CRISPR Products
-
OriGene CRISPR knockouts for FAM98C
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM98C
- GenScript: Design CRISPR guide RNA sequences for FAM98C
miRNA Products
- Search ViGene Biosciences for FAM98C
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FAM98C
- Browse OriGene Inhibitory RNA Products For FAM98C
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM98C gene
Clone Products
-
OriGene ORF clones in human for FAM98C
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||
| SP6: |
Expression for FAM98C Gene
This gene is overexpressed in Peripheral blood mononuclear cells (11.5), Breast (9.8), and Testis (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM98C Gene
NURSA nuclear receptor signaling pathways regulating expression of FAM98C Gene:
FAM98CSOURCE GeneReport for Unigene cluster for FAM98C Gene:
Hs.355162Evidence on tissue expression from TISSUES for FAM98C Gene
- Nervous system(4.3)
- Skin(4.2)
Primer Products
-
OriGene qPCR primer pairs for FAM98C
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM98C Gene
Orthologs for FAM98C Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FAM98C 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FAM98C 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FAM98C 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fam98c 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fam98c 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FAM98C 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | FAM98C 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | FAM98C 35 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG5913 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | tag-322 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for FAM98C was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for FAM98C Gene
(2) SIMAP similar genes for FAM98C Gene using alignment to 5 proteins:
Variants for FAM98C Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs201037487 | Likely pathogenic | 38,407,003(+) | CTGCC(C/T)GAGCC | nc-transcript-variant, reference, stop-gained | |
| rs1000440222 | -- | 38,405,758(+) | CATTT(C/T)ATAAT | intron-variant, utr-variant-3-prime | |
| rs1000955356 | -- | 38,401,965(+) | GTTGG(A/G)TGAAC | upstream-variant-2KB | |
| rs1001446188 | -- | 38,406,934(+) | GGGCA(A/G)TGCTG | nc-transcript-variant, reference, missense | |
| rs1001990772 | -- | 38,402,903(+) | CGGAG(A/G)TCCCG | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3525n100 | CNV | gain | 25217958 |
| nsv1064275 | CNV | loss | 25217958 |
| nsv470140 | CNV | gain | 18288195 |
| nsv833822 | CNV | loss | 17160897 |
| nsv833823 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.10;
80.52% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FAM98C Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM98C Gene
Disorders for FAM98C Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| meckel syndrome 1 |
|
|
Search FAM98C in MalaCards
View complete list of genes associated with diseases
Relevant External Links for FAM98C
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FAM98C
No data available for UniProtKB/Swiss-Prot and Genatlas for FAM98C Gene
Publications for FAM98C Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
- The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64
Products for FAM98C Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
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- Custom Antibody Services
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- Custom Assay Services
- OriGene Purified Proteins for FAM98C
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- Origene Custom Protein Services for FAM98C
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FAM98C
- Browse OriGene Inhibitory RNA Products For FAM98C
- OriGene qPCR primer pairs for FAM98C
- OriGene CRISPR knockouts for FAM98C
- OriGene ORF clones in human for FAM98C
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FAM98C
- GenScript: Next-day shipping cDNA ORF clone for FAM98C in any vector
- GenScript Custom Purified and Recombinant Proteins Services for FAM98C
- GenScript Custom Assay Services for FAM98C
- GenScript Custom overexpressing Cell Line Services for FAM98C
- GenScript: Design CRISPR guide RNA sequences for FAM98C
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Sino Biological Antibodies
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for FAM98C
- Novus Biologicals proteins and lysates for FAM98C
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for FAM98C gene
- ViGene Biosciences lentiviral particle packaged cDNA for FAM98C gene
- ViGene Biosciences ready-to-package AAV shRNAs for FAM98C gene
- Search ViGene Biosciences for FAM98C
- Horizon Cell Lines for FAM98C
- Cyagen custom Knockout/knockin (KOKI) mouse models for FAM98C
- VectorBuilder custom plasmid, inducible vectors for FAM98C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FAM98C
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FAM98C Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer