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Aliases for FAM98C Gene

Aliases for FAM98C Gene

  • Family With Sequence Similarity 98 Member C 2 3 5
  • Family With Sequence Similarity 98, Member C 2

External Ids for FAM98C Gene

Previous GeneCards Identifiers for FAM98C Gene

  • GC19P043586
  • GC19P038893
  • GC19P035341

Summaries for FAM98C Gene

GeneCards Summary for FAM98C Gene

FAM98C (Family With Sequence Similarity 98 Member C) is a Protein Coding gene. Diseases associated with FAM98C include Meckel Syndrome 1. An important paralog of this gene is FAM98A.

Additional gene information for FAM98C Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM98C Gene

Genomics for FAM98C Gene

Regulatory Elements for FAM98C Gene

Enhancers for FAM98C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H038543 1.4 Ensembl ENCODE 11.4 +141.5 141454 2.1 PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF766 ZNF302 ZNF143 ZNF548 HNRNPL ZFP30 ZNF571 ZNF573 ZNF607 ZNF781 PAF1 ENSG00000267152 SUPT5H PLEKHG2
GH19H038269 1.5 Ensembl ENCODE dbSUPER 10.4 -132.4 -132421 1.7 ATF1 ARNT SIN3A FEZF1 ZNF2 TCF12 ZNF121 GLIS2 GATA2 KLF7 CATSPERG C19orf33 HNRNPL ENSG00000266963 HKR1 ZNF607 ENSG00000269445 ENSG00000267375 ENSG00000269172 ZNF793
GH19H038373 1.2 ENCODE 11.8 -27.7 -27733 3.2 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 HNRNPL ZFP30 ZNF571 ZNF573 ZNF781 ZNF540 ZNF793 ENSG00000267152 ZNF607 ZNF569
GH19H038361 1 ENCODE 11 -40.8 -40774 1.6 PKNOX1 ATF1 ZNF133 SIN3A ZNF2 ZBTB7B ZNF121 GLIS2 ELK1 KLF7 C19orf33 CATSPERG ENSG00000266963 ENSG00000269445 ENSG00000267375 ENSG00000269172 GGN SPRED3 FAM98C DPF1
GH19H038453 0.9 ENCODE 11.9 +50.0 50031 0.2 HDAC1 TBP PKNOX1 ATF1 RB1 ZNF350 ATF7 CREM CEBPB HDAC8 HNRNPL FAM98C SPRED3 GGN ENSG00000269688 PAF1 CATSPERG PPP1R14A GC19P038435 GC19P038502
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM98C on UCSC Golden Path with GeneCards custom track

Promoters for FAM98C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109278 175 1401 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF766

Genomic Locations for FAM98C Gene

Genomic Locations for FAM98C Gene
5,964 bases
Plus strand

Genomic View for FAM98C Gene

Genes around FAM98C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM98C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM98C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM98C Gene

Proteins for FAM98C Gene

  • Protein details for FAM98C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM98C
    Protein Accession:
    Secondary Accessions:
    • A6NMW3
    • Q66K45

    Protein attributes for FAM98C Gene

    349 amino acids
    Molecular mass:
    37329 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM98C Gene


neXtProt entry for FAM98C Gene

Post-translational modifications for FAM98C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM98C Gene

No data available for DME Specific Peptides for FAM98C Gene

Domains & Families for FAM98C Gene

Gene Families for FAM98C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM98C Gene


Suggested Antigen Peptide Sequences for FAM98C Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM98 family.
  • Belongs to the FAM98 family.
genes like me logo Genes that share domains with FAM98C: view

Function for FAM98C Gene

Phenotypes From GWAS Catalog for FAM98C Gene

Phenotypes for FAM98C Gene

GenomeRNAi human phenotypes for FAM98C:
genes like me logo Genes that share phenotypes with FAM98C: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM98C Gene

Localization for FAM98C Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM98C gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM98C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0072669 tRNA-splicing ligase complex IBA --
genes like me logo Genes that share ontologies with FAM98C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM98C Gene

Pathways & Interactions for FAM98C Gene

SuperPathways for FAM98C Gene

No Data Available

Interacting Proteins for FAM98C Gene

Gene Ontology (GO) - Biological Process for FAM98C Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM98C Gene

Drugs & Compounds for FAM98C Gene

No Compound Related Data Available

Transcripts for FAM98C Gene

Unigene Clusters for FAM98C Gene

Family with sequence similarity 98, member C:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM98C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - - - -
SP2: - -
SP3: - -
SP4: - - - -

Relevant External Links for FAM98C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM98C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM98C Gene

Protein differential expression in normal tissues from HIPED for FAM98C Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.5), Breast (9.8), and Testis (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM98C Gene

Protein tissue co-expression partners for FAM98C Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM98C Gene:


SOURCE GeneReport for Unigene cluster for FAM98C Gene:


Evidence on tissue expression from TISSUES for FAM98C Gene

  • Nervous system(4.3)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with FAM98C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM98C Gene

Orthologs for FAM98C Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM98C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM98C 33 34
  • 99.43 (n)
(Bos Taurus)
Mammalia FAM98C 33 34
  • 85.79 (n)
(Canis familiaris)
Mammalia FAM98C 33 34
  • 85.39 (n)
(Mus musculus)
Mammalia Fam98c 33 16 34
  • 78.98 (n)
(Rattus norvegicus)
Mammalia Fam98c 33
  • 78.48 (n)
(Monodelphis domestica)
Mammalia FAM98C 34
  • 68 (a)
(Anolis carolinensis)
Reptilia FAM98C 34
  • 37 (a)
(Danio rerio)
Actinopterygii FAM98C 34
  • 25 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5913 34
  • 20 (a)
(Caenorhabditis elegans)
Secernentea tag-322 34
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
Species where no ortholog for FAM98C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FAM98C Gene

Gene Tree for FAM98C (if available)
Gene Tree for FAM98C (if available)

Paralogs for FAM98C Gene

Paralogs for FAM98C Gene

(2) SIMAP similar genes for FAM98C Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM98C: view

Variants for FAM98C Gene

Sequence variations from dbSNP and Humsavar for FAM98C Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs201037487 Likely pathogenic 38,407,003(+) CTGCC(C/T)GAGCC nc-transcript-variant, reference, stop-gained
rs1000440222 -- 38,405,758(+) CATTT(C/T)ATAAT intron-variant, utr-variant-3-prime
rs1000955356 -- 38,401,965(+) GTTGG(A/G)TGAAC upstream-variant-2KB
rs1001446188 -- 38,406,934(+) GGGCA(A/G)TGCTG nc-transcript-variant, reference, missense
rs1001990772 -- 38,402,903(+) CGGAG(A/G)TCCCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM98C Gene

Variant ID Type Subtype PubMed ID
nsv833823 CNV loss 17160897
nsv833822 CNV loss 17160897
nsv470140 CNV gain 18288195
nsv1064275 CNV loss 25217958
dgv3525n100 CNV gain 25217958

Variation tolerance for FAM98C Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.10; 80.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM98C Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM98C Gene

Disorders for FAM98C Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAM98C Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
meckel syndrome 1
  • meckel syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FAM98C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FAM98C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM98C Gene

Publications for FAM98C Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. Characterizing the morbid genome of ciliopathies. (PMID: 27894351) Shaheen R … Alkuraya FS (Genome biology 2016) 3 60
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 60

Products for FAM98C Gene

Sources for FAM98C Gene

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