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Aliases for FAM98C Gene

Aliases for FAM98C Gene

  • Family With Sequence Similarity 98 Member C 2 3 5
  • Family With Sequence Similarity 98, Member C 2

External Ids for FAM98C Gene

Previous GeneCards Identifiers for FAM98C Gene

  • GC19P043586
  • GC19P038893
  • GC19P035341

Summaries for FAM98C Gene

GeneCards Summary for FAM98C Gene

FAM98C (Family With Sequence Similarity 98 Member C) is a Protein Coding gene. Diseases associated with FAM98C include Meckel Syndrome 1. An important paralog of this gene is FAM98A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM98C Gene

Genomics for FAM98C Gene

Regulatory Elements for FAM98C Gene

Enhancers for FAM98C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F038453 0.9 ENCODE 11.9 +50.0 50031 0.2 TBP ATF1 PKNOX1 CBX3 CREB3L1 CREM CEBPB HDAC8 SP1 TFDP1 FAM98C SPRED3 GGN CATSPERG PPP1R14A GC19P038435 GC19P038502
GH19F038373 0.2 ENCODE 11.8 -27.7 -27733 3.2 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 RN7SL566P CATSPERG KCNK6 ZNF573 ENSG00000269688 FBXO17 FAM98C YIF1B PPP1R14A SPINT2
GH19F038543 1.3 Ensembl ENCODE 11.4 +141.5 141537 2.3 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 ZNF302 ZNF143 ZNF607 ZNF573 ZNF571 ENSG00000269688 RN7SL566P RPS16 LOC100631378 ZNF781 FAM98C SUPT5H
GH19F038537 0.3 FANTOM5 11.4 +134.3 134296 0.4 SP2 FAM98C RYR1 RASGRP4 FBXO27 ENSG00000268055 GC19P038542
GH19F038538 0.8 Ensembl ENCODE 11.4 +135.7 135665 0.9 ZBTB10 ZNF121 ZNF362 MTA2 ETV6 TBX21 FAM98C RYR1 RASGRP4 FBXO27 FBXO17 ENSG00000268055 GC19P038542
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM98C on UCSC Golden Path with GeneCards custom track

Promoters for FAM98C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for FAM98C Gene

38,403,125 bp from pter
38,409,088 bp from pter
5,964 bases
Plus strand

Genomic View for FAM98C Gene

Genes around FAM98C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM98C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM98C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM98C Gene

Proteins for FAM98C Gene

  • Protein details for FAM98C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM98C
    Protein Accession:
    Secondary Accessions:
    • A6NMW3
    • Q66K45

    Protein attributes for FAM98C Gene

    349 amino acids
    Molecular mass:
    37329 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM98C Gene


neXtProt entry for FAM98C Gene

Post-translational modifications for FAM98C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM98C Gene

No data available for DME Specific Peptides for FAM98C Gene

Domains & Families for FAM98C Gene

Protein Domains for FAM98C Gene


Suggested Antigen Peptide Sequences for FAM98C Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM98 family.
  • Belongs to the FAM98 family.
genes like me logo Genes that share domains with FAM98C: view

No data available for Gene Families for FAM98C Gene

Function for FAM98C Gene

Phenotypes for FAM98C Gene

GenomeRNAi human phenotypes for FAM98C:
genes like me logo Genes that share phenotypes with FAM98C: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM98C Gene

Localization for FAM98C Gene

Subcellular locations from

Jensen Localization Image for FAM98C Gene COMPARTMENTS Subcellular localization image for FAM98C gene
Compartment Confidence
cytosol 3
nucleus 3
extracellular 1

Gene Ontology (GO) - Cellular Components for FAM98C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0072669 tRNA-splicing ligase complex IBA --
genes like me logo Genes that share ontologies with FAM98C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM98C Gene

Pathways & Interactions for FAM98C Gene

SuperPathways for FAM98C Gene

No Data Available

Interacting Proteins for FAM98C Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000252530 for FAM98C Gene via STRING

Gene Ontology (GO) - Biological Process for FAM98C Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM98C Gene

Transcripts for FAM98C Gene

Unigene Clusters for FAM98C Gene

Family with sequence similarity 98, member C:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM98C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - - - -
SP2: - -
SP3: - -
SP4: - - - -

Relevant External Links for FAM98C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM98C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM98C Gene

Protein differential expression in normal tissues from HIPED for FAM98C Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.5), Breast (9.8), and Testis (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM98C Gene

Protein tissue co-expression partners for FAM98C Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM98C Gene:


SOURCE GeneReport for Unigene cluster for FAM98C Gene:

genes like me logo Genes that share expression patterns with FAM98C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM98C Gene

Orthologs for FAM98C Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM98C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM98C 34 35
  • 99.43 (n)
(Bos Taurus)
Mammalia FAM98C 34 35
  • 85.79 (n)
(Canis familiaris)
Mammalia FAM98C 34 35
  • 85.39 (n)
(Mus musculus)
Mammalia Fam98c 34 16 35
  • 78.98 (n)
(Rattus norvegicus)
Mammalia Fam98c 34
  • 78.48 (n)
(Monodelphis domestica)
Mammalia FAM98C 35
  • 68 (a)
(Anolis carolinensis)
Reptilia FAM98C 35
  • 37 (a)
(Danio rerio)
Actinopterygii FAM98C 35
  • 25 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5913 35
  • 20 (a)
(Caenorhabditis elegans)
Secernentea tag-322 35
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
Species where no ortholog for FAM98C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FAM98C Gene

Gene Tree for FAM98C (if available)
Gene Tree for FAM98C (if available)

Paralogs for FAM98C Gene

Paralogs for FAM98C Gene

(2) SIMAP similar genes for FAM98C Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM98C: view

Variants for FAM98C Gene

Sequence variations from dbSNP and Humsavar for FAM98C Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs201037487 Likely pathogenic 38,407,003(+) CTGCC(C/T)GAGCC nc-transcript-variant, reference, stop-gained
rs10153497 -- 38,406,606(+) ccccc(A/G)tctct intron-variant
rs111241658 -- 38,402,217(+) TCTCC(C/T)GGGCT upstream-variant-2KB
rs111332484 -- 38,408,514(+) AGATC(A/G)CACCA intron-variant
rs111386553 -- 38,406,254(+) CCTCC(C/T)GGGTT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FAM98C Gene

Variant ID Type Subtype PubMed ID
dgv3525n100 CNV gain 25217958
nsv1064275 CNV loss 25217958
nsv470140 CNV gain 18288195
nsv833822 CNV loss 17160897
nsv833823 CNV loss 17160897

Variation tolerance for FAM98C Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.10; 80.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM98C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM98C Gene

Disorders for FAM98C Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAM98C Gene - From: DISEASES

Disorder Aliases PubMed IDs
meckel syndrome 1
  • meckel syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FAM98C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FAM98C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM98C Gene

Publications for FAM98C Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64

Products for FAM98C Gene

Sources for FAM98C Gene

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