FAM98B Gene
protein-coding GIFtS: 41
GCID: GC15P038746
|
|
family with sequence similarity 98, member B
| |
Aliases
for FAM98B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 98, Member B1 2 | | FLJ384261 | | Protein FAM98B2 |
Export aliases for FAM98B gene to outside databasesPrevious GC identifers: GC15P036534 GC15P015591 |
Summaries
for FAM98B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM98B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM98B gene promoter:
Tal-1 Tal-1beta E47 HEN1 CREB E2F-1 E2F deltaCREB ITF-2 En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM98B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM98B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q14 Ensembl cytogenetic band: 15q14 HGNC cytogenetic band: 15q14FAM98B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P038746: view genomic region
(about GC identifiers)
Start:
|
38,746,328 bp from pter |
End:
|
38,779,911 bp from pter |
Size:
|
33,584 bases |
Orientation:
|
plus strand |
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Proteins
for FAM98B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FA98B_HUMAN, Q52LJ0 (See
protein sequence)Recommended Name: Protein FAM98B Size: 330 amino acids; 37191 Da
Subunit: Component of the tRNA-splicing ligase complex
Secondary accessions: A8MUW5 Q8N935Alternative splicing: 2 isoforms: Q52LJ0-1 Q52LJ0-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FAM98B: NX_Q52LJ0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q52LJ0
FAM98B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001035894.1 NP_775882.2
ENSEMBL proteins: ENSP00000380734 ENSP00000453166 ENSP00000453926
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0072669 | tRNA-splicing ligase complex |
IDA | -- |
FAM98B for ontologies About GeneDecksing
FAM98B Antibody Products:
Assay Products for FAM98B: |
Protein
Domains /
Families
for FAM98B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM98B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q52LJ0ProtoNet protein and cluster: Q52LJ0 UniProtKB/Swiss-Prot: FA98B_HUMAN, Q52LJ0Similarity: Belongs to the FAM98 family |
Function
for FAM98B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM98B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM98B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): FAM98B (NM_173611) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM98B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM98B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM98B |
1 GenomeRNAi human phenotype for FAM98B:
|
Pathways & Interactions
for FAM98B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM98B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/14 Interacting proteins for FAM98B (Q52LJ01, 3 ENSP000003807344) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
|
Drugs & Compounds
for FAM98B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM98B
Search CenterWatch for drugs/clinical trials and news about FAM98B / FA98B
|
Transcripts
for FAM98B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM98B gene (2 alternative transcripts): NM_001042429.1 NM_173611.2 Unigene Cluster for FAM98B: Family with sequence similarity 98, member B Hs.744003 [show with all ESTs]Unigene Representative Sequence: AK0957454 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000397609(uc001zkc.3) ENST00000491535(uc001zkb.1) ENST00000305752
ENST00000559431
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM98B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM98B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FAM98B (NM_173611) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM98B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM98B |
Additional cDNA sequence: AK095745.1 BC035600.1 BC045690.1 BC093898.1 7 DOTS entries: DT.100783108 DT.100017984 DT.423968 DT.100009412 DT.100671276 DT.100756647 DT.121077197 24/158 AceView cDNA sequences (see all 158): BU633364 CA427439 AA868832 AA781431 AI221010 BM841931 BC035600 BP872410 CA434101 CB215493 CA433944 AI634962 BG568610 BF940300 BM976047 AI299644 CF144428 AA707520 BF891433 BU633409 H28482 AA187211 CR607099 H39976
GeneLoc Exon Structure
|
Expression
for FAM98B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM98B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See FAM98B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM98B
SOURCE GeneReport for Unigene cluster: Hs.744003
SABiosciences Custom PCR Arrays for FAM98B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM98B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM98B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM98B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM98B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM98B |
Orthologs
for FAM98B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FAM98B gene from 5/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FAM98B1 |
family with sequence similarity 98, member B |
75.36(n)
81.1(a) |
|
423291 XM_421211.3 XP_421211.3 |
lizard
(Anolis carolinensis) |
Reptilia |
FAM98B6 |
-- |
71(a) |
1 ↔ 1 |
1(32652977-32665646) |
zebrafish
(Danio rerio) |
Actinopterygii |
fam98b6 |
family with sequence similarity 98, member B |
46(a) |
1 ↔ 1 |
17(53160227-53165070) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG59136 |
-- |
31(a) |
1 → many |
3R(21719219-21720748) |
worm
(Caenorhabditis elegans) |
Secernentea |
tag-3221 |
Protein TAG-322 |
44.74(n)
28.62(a) |
|
177564 NM_068884.4 NP_501285.1 |
ENSEMBL Gene Tree for FAM98B (if available)
TreeFam Gene Tree for FAM98B (if available) |
Paralogs
for FAM98B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM98B gene
- FAM98C2 FAM98A2
2 SIMAP similar genes for FAM98B using alignment to 2 protein entries: FA98B_HUMAN (see all proteins):FAM98A FAM98C
FAM98B for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for FAM98B
PGOHUM00000239729 PGOHUM00000243744 PGOHUM00000243786
|
Genomic Variants
for FAM98B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM98B (38746328 - 38779911 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM98B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM98B |
|
Disorders
/ Diseases
for FAM98B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FAM98B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM98B gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with FAM98B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- HSPC117 is the essential subunit of a human tRNA splicing ligase complex. (PubMed id 21311021)2 Popow J....Martinez J. (2011)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for FAM98B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM98B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM98B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM98B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM98B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM98B gene:
Search GeneIP for patents involving FAM98B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM98B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM98B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM98B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM98B | | | OriGene Protein Over-expression Lysate for FAM98B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM98B | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM98B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM98B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM98B | | OriGene Custom Protein Services for FAM98B | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM98B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM98B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM98B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM98B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM98B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM98B |
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 |  |  |  | |
| | | | Search Tocris compounds for FAM98B |
| |  |  |  |  | | | | |
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 |
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 | | | FAM98B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM98B |
|  |  |  | | | | ThermoFisher Antibody for FAM98B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM98B |
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