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Aliases for FAM98B Gene

Aliases for FAM98B Gene

  • Family With Sequence Similarity 98 Member B 2 3 5
  • Family With Sequence Similarity 98, Member B 2

External Ids for FAM98B Gene

Previous GeneCards Identifiers for FAM98B Gene

  • GC15P036534
  • GC15P038746
  • GC15P015591

Summaries for FAM98B Gene

GeneCards Summary for FAM98B Gene

FAM98B (Family With Sequence Similarity 98 Member B) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is FAM98C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM98B Gene

Genomics for FAM98B Gene

Regulatory Elements for FAM98B Gene

Enhancers for FAM98B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM98B on UCSC Golden Path with GeneCards custom track

Promoters for FAM98B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM98B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM98B Gene

38,454,127 bp from pter
38,487,710 bp from pter
33,584 bases
Plus strand

Genomic View for FAM98B Gene

Genes around FAM98B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM98B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM98B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM98B Gene

Proteins for FAM98B Gene

  • Protein details for FAM98B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM98B
    Protein Accession:
    Secondary Accessions:
    • A8MUW5
    • Q8N935

    Protein attributes for FAM98B Gene

    330 amino acids
    Molecular mass:
    37191 Da
    Quaternary structure:
    • Component of the tRNA-splicing ligase complex.

    Alternative splice isoforms for FAM98B Gene


neXtProt entry for FAM98B Gene

Proteomics data for FAM98B Gene at MOPED

Post-translational modifications for FAM98B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM98B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM98B Gene

Domains & Families for FAM98B Gene

Protein Domains for FAM98B Gene


Suggested Antigen Peptide Sequences for FAM98B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM98 family.
  • Belongs to the FAM98 family.
genes like me logo Genes that share domains with FAM98B: view

No data available for Gene Families for FAM98B Gene

Function for FAM98B Gene

Phenotypes for FAM98B Gene

genes like me logo Genes that share phenotypes with FAM98B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM98B Gene

Localization for FAM98B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM98B Gene

Nucleus. Cytoplasm.

Subcellular locations from

Jensen Localization Image for FAM98B Gene COMPARTMENTS Subcellular localization image for FAM98B gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for FAM98B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 24608264
genes like me logo Genes that share ontologies with FAM98B: view

Pathways & Interactions for FAM98B Gene

genes like me logo Genes that share pathways with FAM98B: view

Pathways by source for FAM98B Gene

3 Reactome pathways for FAM98B Gene

Interacting Proteins for FAM98B Gene

Gene Ontology (GO) - Biological Process for FAM98B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation TAS --
genes like me logo Genes that share ontologies with FAM98B: view

No data available for SIGNOR curated interactions for FAM98B Gene

Drugs & Compounds for FAM98B Gene

No Compound Related Data Available

Transcripts for FAM98B Gene

Unigene Clusters for FAM98B Gene

Family with sequence similarity 98, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM98B Gene

No ASD Table

Relevant External Links for FAM98B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM98B Gene

mRNA expression in normal human tissues for FAM98B Gene

Protein differential expression in normal tissues from HIPED for FAM98B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM98B Gene

SOURCE GeneReport for Unigene cluster for FAM98B Gene Hs.744003

genes like me logo Genes that share expression patterns with FAM98B: view

Protein tissue co-expression partners for FAM98B Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM98B Gene

Orthologs for FAM98B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM98B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM98B 35
  • 92.12 (n)
  • 94.55 (a)
FAM98B 36
  • 89 (a)
(Canis familiaris)
Mammalia FAM98B 35
  • 91.78 (n)
  • 93.67 (a)
FAM98B 36
  • 85 (a)
(Mus musculus)
Mammalia Fam98b 35
  • 86.26 (n)
  • 90.61 (a)
Fam98b 16
Fam98b 36
  • 86 (a)
(Pan troglodytes)
Mammalia FAM98B 35
  • 99.67 (n)
  • 99.33 (a)
FAM98B 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Fam98b 35
  • 84.78 (n)
  • 89 (a)
(Monodelphis domestica)
Mammalia FAM98B 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia FAM98B 36
  • 54 (a)
(Gallus gallus)
Aves FAM98B 35
  • 76.52 (n)
  • 79.57 (a)
FAM98B 36
  • 74 (a)
(Anolis carolinensis)
Reptilia FAM98B 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam98b 35
  • 64.87 (n)
  • 64.44 (a)
(Danio rerio)
Actinopterygii fam98b 36
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5913 36
  • 32 (a)
(Caenorhabditis elegans)
Secernentea tag-322 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
Species with no ortholog for FAM98B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM98B Gene

Gene Tree for FAM98B (if available)
Gene Tree for FAM98B (if available)

Paralogs for FAM98B Gene

Paralogs for FAM98B Gene

(2) SIMAP similar genes for FAM98B Gene using alignment to 2 proteins: Pseudogenes for FAM98B Gene

genes like me logo Genes that share paralogs with FAM98B: view

Variants for FAM98B Gene

Sequence variations from dbSNP and Humsavar for FAM98B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs11857383 -- 38,466,136(+) TCCTC(C/G)TAGGC intron-variant
rs12101802 -- 38,459,569(+) TTGGG(G/T)GGAAG intron-variant
rs7162389 -- 38,470,500(+) GAGGT(A/G)TACAT intron-variant
rs12385983 -- 38,462,835(+) CATTA(A/G)AAGAA intron-variant
rs12385987 -- 38,462,694(+) AAAAA(C/T)GTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM98B Gene

Variant ID Type Subtype PubMed ID
nsv1500 CNV Loss 18451855

Variation tolerance for FAM98B Gene

Residual Variation Intolerance Score: 39.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.14% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAM98B Gene

Disorders for FAM98B Gene

Relevant External Links for FAM98B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM98B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM98B Gene

Publications for FAM98B Gene

  1. hCLE/C14orf166 Associates with DDX1-HSPC117-FAM98B in a Novel Transcription-Dependent Shuttling RNA-Transporting Complex. (PMID: 24608264) PAcrez-GonzA!lez A. … Nieto A. (PLoS ONE 2014) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for FAM98B Gene

Sources for FAM98B Gene