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Aliases for FAM98B Gene

Aliases for FAM98B Gene

  • Family With Sequence Similarity 98, Member B 2 3

External Ids for FAM98B Gene

Previous GeneCards Identifiers for FAM98B Gene

  • GC15P036534
  • GC15P038746
  • GC15P015591

Summaries for FAM98B Gene

GeneCards Summary for FAM98B Gene

FAM98B (Family With Sequence Similarity 98, Member B) is a Protein Coding gene. An important paralog of this gene is FAM98C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM98B Gene

Genomics for FAM98B Gene

Regulatory Elements for FAM98B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM98B Gene

Start:
38,454,127 bp from pter
End:
38,487,710 bp from pter
Size:
33,584 bases
Orientation:
Plus strand

Genomic View for FAM98B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM98B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM98B Gene

Proteins for FAM98B Gene

  • Protein details for FAM98B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q52LJ0-FA98B_HUMAN
    Recommended name:
    Protein FAM98B
    Protein Accession:
    Q52LJ0
    Secondary Accessions:
    • A8MUW5
    • Q8N935

    Protein attributes for FAM98B Gene

    Size:
    330 amino acids
    Molecular mass:
    37191 Da
    Quaternary structure:
    • Component of the tRNA-splicing ligase complex.

    Alternative splice isoforms for FAM98B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM98B Gene

Proteomics data for FAM98B Gene at MOPED

Post-translational modifications for FAM98B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM98B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FAM98B Gene

Domains for FAM98B Gene

Protein Domains for FAM98B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM98B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q52LJ0

UniProtKB/Swiss-Prot:

FA98B_HUMAN :
  • Q52LJ0
Family:
  • Belongs to the FAM98 family.
genes like me logo Genes that share domains with FAM98B: view

No data available for Gene Families for FAM98B Gene

Function for FAM98B Gene

Gene Ontology (GO) - Molecular Function for FAM98B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with FAM98B: view

Phenotypes for FAM98B Gene

GenomeRNAi human phenotypes for FAM98B:
genes like me logo Genes that share phenotypes with FAM98B: view

Animal Model Products

CRISPR Products

miRNA for FAM98B Gene

miRTarBase miRNAs that target FAM98B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM98B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM98B Gene

Localization for FAM98B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM98B Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM98B Gene COMPARTMENTS Subcellular localization image for FAM98B gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FAM98B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 24608264
GO:0005737 cytoplasm IDA 24608264
GO:0072669 tRNA-splicing ligase complex IDA 21311021
genes like me logo Genes that share ontologies with FAM98B: view

Pathways for FAM98B Gene

SuperPathways for FAM98B Gene

No Data Available

Interacting Proteins for FAM98B Gene

Gene Ontology (GO) - Biological Process for FAM98B Gene

None

No data available for Pathways by source for FAM98B Gene

Transcripts for FAM98B Gene

mRNA/cDNA for FAM98B Gene

Unigene Clusters for FAM98B Gene

Family with sequence similarity 98, member B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM98B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM98B Gene

No ASD Table

Relevant External Links for FAM98B Gene

GeneLoc Exon Structure for
FAM98B
ECgene alternative splicing isoforms for
FAM98B

Expression for FAM98B Gene

mRNA expression in normal human tissues for FAM98B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for FAM98B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM98B Gene

SOURCE GeneReport for Unigene cluster for FAM98B Gene Hs.744003

genes like me logo Genes that share expressions with FAM98B: view

Expression partners for FAM98B Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM98B Gene

Orthologs for FAM98B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM98B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM98B 35
  • 92.12 (n)
  • 94.55 (a)
FAM98B 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM98B 35
  • 91.78 (n)
  • 93.67 (a)
FAM98B 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam98b 35
  • 86.26 (n)
  • 90.61 (a)
Fam98b 16
Fam98b 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM98B 35
  • 99.67 (n)
  • 99.33 (a)
FAM98B 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam98b 35
  • 84.78 (n)
  • 89 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM98B 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM98B 36
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM98B 35
  • 76.52 (n)
  • 79.57 (a)
FAM98B 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM98B 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam98b 35
  • 64.87 (n)
  • 64.44 (a)
zebrafish
(Danio rerio)
Actinopterygii fam98b 36
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5913 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-322 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
Species with no ortholog for FAM98B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM98B Gene

ENSEMBL:
Gene Tree for FAM98B (if available)
TreeFam:
Gene Tree for FAM98B (if available)

Paralogs for FAM98B Gene

Paralogs for FAM98B Gene

Selected SIMAP similar genes for FAM98B Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for FAM98B Gene

genes like me logo Genes that share paralogs with FAM98B: view

Variants for FAM98B Gene

Sequence variations from dbSNP and Humsavar for FAM98B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1127369 -- 38,485,179(+) AATCA(C/T)TTTTT utr-variant-3-prime
rs4077850 -- 38,459,556(-) AGCCC(A/G)CACCT intron-variant
rs4271555 -- 38,476,795(+) gcttc(C/T)tcagc intron-variant
rs4301981 -- 38,483,686(+) AAAAA(A/T)ATATA intron-variant
rs4482237 -- 38,476,465(+) AAATG(C/G)TTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM98B Gene

Variant ID Type Subtype PubMed ID
nsv1500 CNV Loss 18451855

Relevant External Links for FAM98B Gene

HapMap Linkage Disequilibrium report
FAM98B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM98B Gene

Disorders for FAM98B Gene

No disorders were found for FAM98B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FAM98B Gene

Publications for FAM98B Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. HSPC117 is the essential subunit of a human tRNA splicing ligase complex. (PMID: 21311021) Popow J. … Martinez J. (Science 2011) 3 4
  5. hCLE/C14orf166 Associates with DDX1-HSPC117-FAM98B in a Novel Transcription-Dependent Shuttling RNA-Transporting Complex. (PMID: 24608264) PAcrez-GonzA!lez A. … Nieto A. (PLoS ONE 2014) 3 4

Products for FAM98B Gene

Sources for FAM98B Gene

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