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Aliases for FAM98A Gene

Aliases for FAM98A Gene

  • Family With Sequence Similarity 98 Member A 2 3 5
  • Family With Sequence Similarity 98, Member A 2

External Ids for FAM98A Gene

Previous GeneCards Identifiers for FAM98A Gene

  • GC02M033721
  • GC02M033808
  • GC02M033542

Summaries for FAM98A Gene

GeneCards Summary for FAM98A Gene

FAM98A (Family With Sequence Similarity 98 Member A) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is FAM98B.

Additional gene information for FAM98A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM98A Gene

Genomics for FAM98A Gene

Regulatory Elements for FAM98A Gene

Enhancers for FAM98A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H033597 1.4 FANTOM5 ENCODE 13.1 +0.5 509 2 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 FAM98A LTBP1 RASGRP3 GC02P033593
GH02H033491 1.4 Ensembl ENCODE dbSUPER 11.4 +103.4 103356 9 HDGF PKNOX1 TBL1XR1 NFIB BMI1 BATF RFX5 FOS ATF7 ETV6 FAM98A ATP6V0E1P3 LOC105374454 RASGRP3
GH02H033582 0.9 Ensembl ENCODE 15.1 +15.9 15912 1 CTCF ZNF654 ZNF362 TRIM22 REST RAD21 KLF16 ZNF143 SMC3 RUNX3 FAM98A GC02P033576 GC02P033593
GH02H033607 0.5 ENCODE 17.3 -8.0 -7999 1 POLR2A ZFP64 POU5F1 MAFK FAM98A RASGRP3 GC02P033602 HNRNPA1P61
GH02H033500 0.6 dbSUPER 10.1 +89.7 89749 17 POLR2A CREB1 JUNB CEBPG FOS REST BATF FOXA1 RASGRP3 LOC105374454 FAM98A ATP6V0E1P3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM98A on UCSC Golden Path with GeneCards custom track

Promoters for FAM98A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000115181 282 2201 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for FAM98A Gene

Chromosome:
2
Start:
33,583,658 bp from pter
End:
33,599,382 bp from pter
Size:
15,725 bases
Orientation:
Minus strand

Genomic View for FAM98A Gene

Genes around FAM98A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM98A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM98A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM98A Gene

Proteins for FAM98A Gene

  • Protein details for FAM98A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCA5-FA98A_HUMAN
    Recommended name:
    Protein FAM98A
    Protein Accession:
    Q8NCA5
    Secondary Accessions:
    • B2RNA2
    • Q9Y3Y6

    Protein attributes for FAM98A Gene

    Size:
    519 amino acids
    Molecular mass:
    55401 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM98A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM98A Gene

Post-translational modifications for FAM98A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM98A Gene

No data available for DME Specific Peptides for FAM98A Gene

Domains & Families for FAM98A Gene

Gene Families for FAM98A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM98A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM98A Gene

Graphical View of Domain Structure for InterPro Entry

Q8NCA5

UniProtKB/Swiss-Prot:

FA98A_HUMAN :
  • Belongs to the FAM98 family.
Family:
  • Belongs to the FAM98 family.
genes like me logo Genes that share domains with FAM98A: view

Function for FAM98A Gene

Phenotypes From GWAS Catalog for FAM98A Gene

Gene Ontology (GO) - Molecular Function for FAM98A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 25416956
GO:0008276 protein methyltransferase activity IMP 28040436
genes like me logo Genes that share ontologies with FAM98A: view
genes like me logo Genes that share phenotypes with FAM98A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM98A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM98A Gene

Localization for FAM98A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM98A gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FAM98A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0072669 tRNA-splicing ligase complex IBA --
genes like me logo Genes that share ontologies with FAM98A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM98A Gene

Pathways & Interactions for FAM98A Gene

SuperPathways for FAM98A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM98A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006479 protein methylation IMP 28040436
GO:0008284 positive regulation of cell proliferation IMP 28040436
GO:0010628 positive regulation of gene expression IMP 28040436
GO:0032418 lysosome localization ISS --
GO:1900029 positive regulation of ruffle assembly ISS --
genes like me logo Genes that share ontologies with FAM98A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM98A Gene

Drugs & Compounds for FAM98A Gene

No Compound Related Data Available

Transcripts for FAM98A Gene

Unigene Clusters for FAM98A Gene

Family with sequence similarity 98, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM98A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FAM98A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - -
SP2: - -
SP3:
SP4:

Relevant External Links for FAM98A Gene

GeneLoc Exon Structure for
FAM98A
ECgene alternative splicing isoforms for
FAM98A

Expression for FAM98A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM98A Gene

Protein differential expression in normal tissues from HIPED for FAM98A Gene

This gene is overexpressed in Lung (16.8), Bone marrow stromal cell (14.5), and Breast (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM98A Gene



Protein tissue co-expression partners for FAM98A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM98A Gene:

FAM98A

SOURCE GeneReport for Unigene cluster for FAM98A Gene:

Hs.468140

Evidence on tissue expression from TISSUES for FAM98A Gene

  • Nervous system(4.8)
  • Liver(4.3)
  • Kidney(2.5)
genes like me logo Genes that share expression patterns with FAM98A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM98A Gene

Orthologs for FAM98A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM98A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM98A 33 34
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia FAM98A 34 33
  • 94.97 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM98A 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM98A 34 33
  • 92.51 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam98a 33
  • 91.07 (n)
mouse
(Mus musculus)
Mammalia Fam98a 33 16 34
  • 90.36 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM98A 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM98A 34 33
  • 72.5 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM98A 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488558 33
  • 71.12 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2395 33
zebrafish
(Danio rerio)
Actinopterygii fam98a 34
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011248 33
  • 48.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5913 33 34
  • 46.6 (n)
worm
(Caenorhabditis elegans)
Secernentea tag-322 34
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
OneToMany
Species where no ortholog for FAM98A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM98A Gene

ENSEMBL:
Gene Tree for FAM98A (if available)
TreeFam:
Gene Tree for FAM98A (if available)

Paralogs for FAM98A Gene

Paralogs for FAM98A Gene

(2) SIMAP similar genes for FAM98A Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FAM98A: view

Variants for FAM98A Gene

Sequence variations from dbSNP and Humsavar for FAM98A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000238410 -- 33,594,698(+) ACACA(C/T)ATATA intron-variant
rs1000251531 -- 33,599,649(+) CTCTG(C/T)ATCCC upstream-variant-2KB
rs1000498688 -- 33,590,242(+) GGCCA(A/G)TGAAG intron-variant
rs1000700693 -- 33,596,150(+) CTGGC(-/T)TTTTT intron-variant
rs1000827508 -- 33,597,640(+) CAATT(C/T)TTAAG intron-variant

Variation tolerance for FAM98A Gene

Residual Variation Intolerance Score: 66.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM98A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM98A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM98A Gene

Disorders for FAM98A Gene

Relevant External Links for FAM98A

Genetic Association Database (GAD)
FAM98A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM98A

No disorders were found for FAM98A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM98A Gene

Publications for FAM98A Gene

  1. A divergent calponin homology (NN-CH) domain defines a novel family: implications for evolution of ciliary IFT complex B proteins. (PMID: 24257188) Schou KB … Pedersen LB (Bioinformatics (Oxford, England) 2014) 2 3 60
  2. Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan. (PMID: 19421330) Yang HC … Pan WH (PloS one 2009) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression. (PMID: 28040436) Akter KA … Senga T (The international journal of biochemistry & cell biology 2016) 3 60

Products for FAM98A Gene

Sources for FAM98A Gene

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