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Aliases for FAM98A Gene

Aliases for FAM98A Gene

  • Family With Sequence Similarity 98 Member A 2 3 5
  • Family With Sequence Similarity 98, Member A 2

External Ids for FAM98A Gene

Previous GeneCards Identifiers for FAM98A Gene

  • GC02M033721
  • GC02M033808
  • GC02M033542

Summaries for FAM98A Gene

GeneCards Summary for FAM98A Gene

FAM98A (Family With Sequence Similarity 98 Member A) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is FAM98C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM98A Gene

Genomics for FAM98A Gene

Regulatory Elements for FAM98A Gene

Promoters for FAM98A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM98A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM98A Gene

Chromosome:
2
Start:
33,583,658 bp from pter
End:
33,599,382 bp from pter
Size:
15,725 bases
Orientation:
Minus strand

Genomic View for FAM98A Gene

Genes around FAM98A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM98A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM98A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM98A Gene

Proteins for FAM98A Gene

  • Protein details for FAM98A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCA5-FA98A_HUMAN
    Recommended name:
    Protein FAM98A
    Protein Accession:
    Q8NCA5
    Secondary Accessions:
    • B2RNA2
    • Q9Y3Y6

    Protein attributes for FAM98A Gene

    Size:
    519 amino acids
    Molecular mass:
    55401 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM98A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM98A Gene

Proteomics data for FAM98A Gene at MOPED

Post-translational modifications for FAM98A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM98A Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for FAM98A

No data available for DME Specific Peptides for FAM98A Gene

Domains & Families for FAM98A Gene

Protein Domains for FAM98A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM98A Gene

Graphical View of Domain Structure for InterPro Entry

Q8NCA5

UniProtKB/Swiss-Prot:

FA98A_HUMAN :
  • Belongs to the FAM98 family.
Family:
  • Belongs to the FAM98 family.
genes like me logo Genes that share domains with FAM98A: view

No data available for Gene Families for FAM98A Gene

Function for FAM98A Gene

Gene Ontology (GO) - Molecular Function for FAM98A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with FAM98A: view
genes like me logo Genes that share phenotypes with FAM98A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM98A Gene

Localization for FAM98A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM98A Gene COMPARTMENTS Subcellular localization image for FAM98A gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM98A Gene

Pathways & Interactions for FAM98A Gene

SuperPathways for FAM98A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM98A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM98A Gene

Drugs & Compounds for FAM98A Gene

No Compound Related Data Available

Transcripts for FAM98A Gene

Unigene Clusters for FAM98A Gene

Family with sequence similarity 98, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM98A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - -
SP2: - -
SP3:
SP4:

Relevant External Links for FAM98A Gene

GeneLoc Exon Structure for
FAM98A
ECgene alternative splicing isoforms for
FAM98A

Expression for FAM98A Gene

mRNA expression in normal human tissues for FAM98A Gene

Protein differential expression in normal tissues from HIPED for FAM98A Gene

This gene is overexpressed in Lung (16.8), Bone marrow stromal cell (14.5), and Breast (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM98A Gene



SOURCE GeneReport for Unigene cluster for FAM98A Gene Hs.468140

genes like me logo Genes that share expression patterns with FAM98A: view

Protein tissue co-expression partners for FAM98A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM98A Gene

Orthologs for FAM98A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM98A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM98A 35
  • 92.51 (n)
  • 96.51 (a)
FAM98A 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM98A 35
  • 94.97 (n)
  • 97.68 (a)
FAM98A 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam98a 35
  • 90.36 (n)
  • 93.59 (a)
Fam98a 16
Fam98a 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM98A 35
  • 99.68 (n)
  • 99.42 (a)
FAM98A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam98a 35
  • 91.07 (n)
  • 93.79 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM98A 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM98A 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM98A 35
  • 72.5 (n)
  • 71.67 (a)
FAM98A 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM98A 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488558 35
  • 71.12 (n)
  • 74.61 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2395 35
zebrafish
(Danio rerio)
Actinopterygii fam98a 36
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011248 35
  • 48.07 (n)
  • 44.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5913 35
  • 46.6 (n)
  • 37.93 (a)
CG5913 36
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-322 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for FAM98A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM98A Gene

ENSEMBL:
Gene Tree for FAM98A (if available)
TreeFam:
Gene Tree for FAM98A (if available)

Paralogs for FAM98A Gene

Paralogs for FAM98A Gene

(2) SIMAP similar genes for FAM98A Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FAM98A: view

Variants for FAM98A Gene

Sequence variations from dbSNP and Humsavar for FAM98A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs3023 -- 33,592,814(+) CTTCC(C/T)AGCAT intron-variant
rs11066 -- 33,584,227(-) CTCTT(C/T)TGCAG utr-variant-3-prime
rs935625 -- 33,586,449(+) AAATC(C/G)CTATG intron-variant
rs1375198 -- 33,591,518(+) AAAAA(C/T)TCATT intron-variant
rs1375199 -- 33,596,331(+) GTTAG(C/G)TTAAT intron-variant

Variation tolerance for FAM98A Gene

Residual Variation Intolerance Score: 66.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM98A Gene

HapMap Linkage Disequilibrium report
FAM98A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM98A Gene

Disorders for FAM98A Gene

Relevant External Links for FAM98A

Genetic Association Database (GAD)
FAM98A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM98A

No disorders were found for FAM98A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM98A Gene

Publications for FAM98A Gene

  1. A divergent calponin homology (NN-CH) domain defines a novel family: implications for evolution of ciliary IFT complex B proteins. (PMID: 24257188) Schou K.B. … Pedersen L.B. (Bioinformatics 2014) 2 3 67
  2. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for FAM98A Gene

Sources for FAM98A Gene

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