FAM98A Gene
protein-coding GIFtS: 41
GCID: GC02M033808
|
|
family with sequence similarity 98, member A
| |
Aliases
for FAM98A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 98, Member A1 2 | | DKFZP564F05221 | | Protein FAM98A2 |
Export aliases for FAM98A gene to outside databasesPrevious GC identifers: GC02M033721 GC02M033542 |
Summaries
for FAM98A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM98A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM98A gene promoter:
Bach1 AML1a Pax-6 MIF-1 C/EBPalpha CHOP-10 Pax-3 Nkx6-1 c-Myb Zic3
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM98A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM98A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p22.3 Ensembl cytogenetic band: 2p22.3 HGNC cytogenetic band: 2p22.3FAM98A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M033808: view genomic region
(about GC identifiers)
Start:
|
33,808,725 bp from pter |
End:
|
33,824,449 bp from pter |
Size:
|
15,725 bases |
Orientation:
|
minus strand |
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Proteins
for FAM98A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FA98A_HUMAN, Q8NCA5 (See
protein sequence)Recommended Name: Protein FAM98A Size: 519 amino acids; 55401 Da
Secondary accessions: B2RNA2 Q9Y3Y6Alternative splicing: 2 isoforms: Q8NCA5-1 Q8NCA5-2 Explore the universe of human proteins at neXtProt for FAM98A: NX_Q8NCA5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NCA5
FAM98A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056290.3
ENSEMBL proteins: ENSP00000238823 ENSP00000384711 ENSP00000398490 ENSP00000408716
Human Recombinant Protein Products:
FAM98A Antibody Products:
Assay Products for FAM98A: |
Protein
Domains /
Families
for FAM98A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM98A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8NCA5ProtoNet protein and cluster: Q8NCA5 UniProtKB/Swiss-Prot: FA98A_HUMAN, Q8NCA5Similarity: Belongs to the FAM98 family |
Function
for FAM98A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM98A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM98A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FAM98A (NM_015475) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM98A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM98A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM98A |
1 GenomeRNAi human phenotype for FAM98A:
|
Pathways & Interactions
for FAM98A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM98A
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/16 Interacting proteins for FAM98A (Q8NCA53 ENSP000002388234) via UniProtKB, MINT, STRING, and/or I2D (see all 16)About this table
|
Drugs & Compounds
for FAM98A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM98A
Search CenterWatch for drugs/clinical trials and news about FAM98A / FA98A
|
Transcripts
for FAM98A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM98A gene: NM_015475.3 Unigene Cluster for FAM98A: Family with sequence similarity 98, member A Hs.468140 [show with all ESTs]Unigene Representative Sequence: AK0961879 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000238823(uc010ynd.1 uc002rpa.1 uc010yne.1) ENST00000474985(uc002roz.1)
ENST00000403368 ENST00000475122 ENST00000492649 ENST00000498340 ENST00000464415
ENST00000431950 ENST00000441530
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM98A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM98A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FAM98A (NM_015475) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM98A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM98A |
Additional cDNA sequence: AK027432.1 AK074867.1 AK096187.1 AK300023.1 AK302233.1 AL049943.1 BC020907.1 BC038581.1 BC060860.1 BC136768.1 BC136770.1 CR936766.1 8 DOTS entries: DT.87016629 DT.100024063 DT.100682604 DT.120937110 DT.99993061 DT.91654074 DT.120937104 DT.95255098 24/234 AceView cDNA sequences (see all 234): BF149302 AI989330 BM015694 AA223228 BQ962891 CR625595 AA723042 AA789041 BU786083 AI082517 AI125594 CB155633 BQ417317 BE220762 AI347869 BG106497 BF149303 BM667986 BI871011 N23187 BF445863 BU182038 R63333 BC060860
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for FAM98A About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FAM98A
|
Expression
for FAM98A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM98A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See FAM98A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM98A
SOURCE GeneReport for Unigene cluster: Hs.468140
SABiosciences Custom PCR Arrays for FAM98A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM98A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM98A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM98A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM98A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM98A |
Orthologs
for FAM98A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FAM98A gene from 6/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FAM98A1 |
family with sequence similarity 98, member A |
80.98(n)
89.36(a) |
|
421458 NM_001031057.1 NP_001026228.1 |
lizard
(Anolis carolinensis) |
Reptilia |
FAM98A6 |
-- |
85(a) |
1 ↔ 1 |
1(231342208-231356042) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.23952 |
Xenopus laevis transcribed sequence with moderate similarity more |
77.5(n) |
|
BJ040577.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
fam98a1 |
family with sequence similarity 98, member A |
67.8(n)
74.7(a) |
|
559900 XM_679482.5 XP_684574.3 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG59131 |
CG5913 |
46.99(n)
39.82(a) |
|
43132 NM_143182.3 NP_651439.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
tag-3226 |
Temporarily Assigned Gene name family member (tag-... |
24(a) |
1 → many |
IV(7783955-7785553) |
ENSEMBL Gene Tree for FAM98A (if available)
TreeFam Gene Tree for FAM98A (if available) |
Paralogs
for FAM98A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM98A gene
- FAM98C2 FAM98B2
2 SIMAP similar genes for FAM98A using alignment to 6 protein entries: FA98A_HUMAN (see all proteins):FAM98B FAM98C
FAM98A for paralogs About GeneDecksing
|
Genomic Variants
for FAM98A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM98A (33808725 - 33824449 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM98A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM98A |
|
Disorders
/ Diseases
for FAM98A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FAM98A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM98A gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with FAM98A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling. (PubMed id 20639865)1 Xu G....Jaffrey S.R. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1 Meierhofer D.... Kaiser P. (2008)
|
External Searches for FAM98A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM98A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM98A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM98A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM98A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM98A gene:
Search GeneIP for patents involving FAM98A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM98A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM98A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM98A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM98A | | | OriGene Protein Over-expression Lysate for FAM98A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM98A | | OriGene 3'-UTR Clone for FAM98A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM98A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM98A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM98A | | OriGene Custom Protein Services for FAM98A | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM98A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM98A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM98A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM98A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM98A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM98A |
| |
 |  |  |  | |
| | | | Search Tocris compounds for FAM98A |
| |  |  |  |  | | | | |
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 |
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 | | | FAM98A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM98A |
|  |  |  | | | | Search ThermoFisher Antibodies for FAM98A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM98A |
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