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Aliases for FAM96B Gene

Aliases for FAM96B Gene

  • Family With Sequence Similarity 96, Member B 2 3
  • MIP18 3 4 6
  • MSS19-Interacting Protein Of 18 KDa 3 4
  • Mitotic Spindle-Associated MMXD Complex Subunit MIP18 3
  • Protein FAM96B 4
  • CGI-128 3

External Ids for FAM96B Gene

Previous GeneCards Identifiers for FAM96B Gene

  • GC16M065524
  • GC16M066965
  • GC16M052840

Summaries for FAM96B Gene

GeneCards Summary for FAM96B Gene

FAM96B (Family With Sequence Similarity 96, Member B) is a Protein Coding gene. Among its related pathways are Metabolism and Cytosolic Iron-sulfur Cluster Assembly. An important paralog of this gene is FAM96A.

UniProtKB/Swiss-Prot for FAM96B Gene

  • Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM96B Gene

Genomics for FAM96B Gene

Regulatory Elements for FAM96B Gene

Transcription factor binding sites by QIAGEN in the FAM96B gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM96B Gene

Start:
66,932,055 bp from pter
End:
66,934,423 bp from pter
Size:
2,369 bases
Orientation:
Minus strand

Genomic View for FAM96B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM96B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM96B Gene

Proteins for FAM96B Gene

  • Protein details for FAM96B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3D0-MIP18_HUMAN
    Recommended name:
    Mitotic spindle-associated MMXD complex subunit MIP18
    Protein Accession:
    Q9Y3D0
    Secondary Accessions:

    Protein attributes for FAM96B Gene

    Size:
    163 amino acids
    Molecular mass:
    17663 Da
    Quaternary structure:
    • Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with ERCC2 and MMS19; the interaction is direct.

neXtProt entry for FAM96B Gene

Proteomics data for FAM96B Gene at MOPED

Post-translational modifications for FAM96B Gene

  • Ubiquitination at Lys116
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM96B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM96B Gene

Domains for FAM96B Gene

Protein Domains for FAM96B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM96B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3D0

UniProtKB/Swiss-Prot:

MIP18_HUMAN :
  • Q9Y3D0
Family:
  • Belongs to the MIP18 family.
genes like me logo Genes that share domains with FAM96B: view

No data available for Gene Families for FAM96B Gene

Function for FAM96B Gene

Molecular function for FAM96B Gene

UniProtKB/Swiss-Prot Function: Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD.

Gene Ontology (GO) - Molecular Function for FAM96B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with FAM96B: view

Animal Model Products

CRISPR Products

miRNA for FAM96B Gene

miRTarBase miRNAs that target FAM96B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM96B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM96B Gene

Localization for FAM96B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM96B Gene

Nucleus. Cytoplasm, cytoskeleton, spindle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM96B Gene COMPARTMENTS Subcellular localization image for FAM96B gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FAM96B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20797633
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005819 spindle IDA 20797633
GO:0071817 MMXD complex IDA 20797633
genes like me logo Genes that share ontologies with FAM96B: view

Pathways for FAM96B Gene

genes like me logo Genes that share pathways with FAM96B: view

Pathways by source for FAM96B Gene

2 Reactome pathways for FAM96B Gene

Gene Ontology (GO) - Biological Process for FAM96B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007059 chromosome segregation IMP 20797633
GO:0016226 iron-sulfur cluster assembly IBA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with FAM96B: view

Transcripts for FAM96B Gene

Unigene Clusters for FAM96B Gene

Family with sequence similarity 96, member B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM96B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM96B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: -
SP2: - -
SP3: - -
SP4: -

Relevant External Links for FAM96B Gene

GeneLoc Exon Structure for
FAM96B
ECgene alternative splicing isoforms for
FAM96B

Expression for FAM96B Gene

mRNA expression in normal human tissues for FAM96B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM96B Gene

SOURCE GeneReport for Unigene cluster for FAM96B Gene Hs.9825

genes like me logo Genes that share expressions with FAM96B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM96B Gene

Orthologs for FAM96B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FAM96B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM96B 35
  • 98.53 (n)
  • 100 (a)
FAM96B 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM96B 35
  • 90.39 (n)
  • 97.55 (a)
FAM96B 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM96B 35
  • 89.76 (n)
  • 96.73 (a)
FAM96B 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam96b 35
  • 86.49 (n)
  • 98.04 (a)
Fam96b 16
Fam96b 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM96B 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam96b 35
  • 87.15 (n)
  • 98.04 (a)
chicken
(Gallus gallus)
Aves FAM96B 35
  • 77.41 (n)
  • 91.45 (a)
FAM96B 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM96B 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10194 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fam96b 35
  • 73.9 (n)
  • 87.5 (a)
Str.468 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10450 35
zebrafish
(Danio rerio)
Actinopterygii fam96b 35
  • 72.37 (n)
  • 84.87 (a)
fam96b 36
  • 82 (a)
OneToOne
wufc08f04 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005422 35
  • 64.67 (n)
  • 68.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7949 35
  • 65.35 (n)
  • 71.05 (a)
CG7949 36
  • 69 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F45G2.10 35
  • 58.56 (n)
  • 62.16 (a)
F45G2.10 36
  • 58 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR343W 35
  • 55.32 (n)
  • 54.61 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 33 (a)
OneToMany
CIA2 35
  • 52.07 (n)
  • 54.74 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F24332g 35
  • 52.45 (n)
  • 57.36 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2327 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G68310 35
  • 58.22 (n)
  • 58 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.9354 35
rice
(Oryza sativa)
Liliopsida Os.45029 35
Os04g0595200 35
  • 58.39 (n)
  • 58.39 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02573 35
  • 52.27 (n)
  • 43.94 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC144.16 35
  • 56.21 (n)
  • 61.86 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2545 35
Species with no ortholog for FAM96B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM96B Gene

ENSEMBL:
Gene Tree for FAM96B (if available)
TreeFam:
Gene Tree for FAM96B (if available)

Paralogs for FAM96B Gene

Paralogs for FAM96B Gene

Selected SIMAP similar genes for FAM96B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FAM96B: view

Variants for FAM96B Gene

Sequence variations from dbSNP and Humsavar for FAM96B Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs79044911 -- 66,932,084(+) CTTTA(C/T)TACAA utr-variant-3-prime, nc-transcript-variant
rs79251147 -- 66,932,180(+) ATGCA(G/T)GCTGA utr-variant-3-prime, nc-transcript-variant
rs112983388 -- 66,931,621(+) GCCTG(A/G)GCAAC downstream-variant-500B
rs117650315 -- 66,931,692(+) CCAGA(C/T)ATGCC downstream-variant-500B
rs144988287 -- 66,931,752(+) GTATT(A/G)TGGCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FAM96B Gene

Variant ID Type Subtype PubMed ID
dgv2885n71 CNV Loss 21882294
nsv827706 CNV Loss 20364138
nsv906791 CNV Loss 21882294
nsv906792 CNV Loss 21882294

Relevant External Links for FAM96B Gene

HapMap Linkage Disequilibrium report
FAM96B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM96B Gene

Disorders for FAM96B Gene

No disorders were found for FAM96B Gene.

No data available for UniProtKB/Swiss-Prot for FAM96B Gene

Publications for FAM96B Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation. (PMID: 20797633) Ito S. … Tanaka K. (Mol. Cell 2010) 3 4
  5. MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism. (PMID: 22678361) Gari K. … Boulton S.J. (Science 2012) 3 4

Products for FAM96B Gene

Sources for FAM96B Gene

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