Aliases for FAM96B Gene
Aliases for FAM96B Gene
External Ids for FAM96B Gene
- HGNC: 24261
- Entrez Gene: 51647
- Ensembl: ENSG00000166595
- OMIM: 614778
- UniProtKB: Q9Y3D0
Previous GeneCards Identifiers for FAM96B Gene
- GC16M065524
- GC16M066965
- GC16M052840
Summaries for FAM96B Gene
GeneCards Summary for FAM96B Gene
FAM96B (Family With Sequence Similarity 96 Member B) is a Protein Coding gene. Among its related pathways are Cytosolic iron-sulfur cluster assembly and Glucose / Energy Metabolism. An important paralog of this gene is FAM96A.
UniProtKB/Swiss-Prot for FAM96B Gene
-
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM96B Gene
Genomics for FAM96B Gene
Regulatory Elements for FAM96B Gene
- Transcription factor binding sites by QIAGEN in the FAM96B gene promoter:
Regulatory Element Products
Genomic Location for FAM96B Gene
- Chromosome:
- 16
- Start:
- 66,932,055 bp from pter
- End:
- 66,934,423 bp from pter
- Size:
- 2,369 bases
- Orientation:
- Minus strand
Genomic View for FAM96B Gene
- Cytogenetic band:
-
- 16q22.1 by Ensembl
- 16q22.1 by Entrez Gene
- 16q22.1 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FAM96B Gene
Proteins for FAM96B Gene
-
Protein details for FAM96B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y3D0-MIP18_HUMAN
- Recommended name:
- Mitotic spindle-associated MMXD complex subunit MIP18
- Protein Accession:
- Q9Y3D0
Protein attributes for FAM96B Gene
- Size:
- 163 amino acids
- Molecular mass:
- 17663 Da
- Quaternary structure:
-
- Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with ERCC2 and MMS19; the interaction is direct.
Protein Expression for FAM96B Gene
Post-translational modifications for FAM96B Gene
Other Protein References for FAM96B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for FAM96B (FAM96B)
-
Custom Antibody ServicesOriGene Antibodies for FAM96B
- Novus Biologicals Antibodies for FAM96B
-
Abcam antibodies for FAM96B
- Invitrogen Antibodies for FAM96B
- antibodies-online Antibodies for FAM96B: See all 38
- Search GeneTex for Antibodies for FAM96B
-
Santa Cruz Biotechnology (SCBT) Antibodies for FAM96B
Protein Products
-
OriGene Purified Proteins for FAM96B
- Search Origene for MassSpec and Protein Over-expression Lysates for FAM96B
- Origene Custom Protein Services for FAM96B
- antibodies-online Proteins for FAM96B: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FAM96B
-
Abcam proteins for FAM96B
Assay Products
No data available for DME Specific Peptides for FAM96B Gene
Domains & Families for FAM96B Gene
Gene Families for FAM96B Gene
Protein Domains for FAM96B Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FAM96B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y3D0- Family:
-
- Belongs to the MIP18 family.
Function for FAM96B Gene
Molecular function for FAM96B Gene
- UniProtKB/Swiss-Prot Function:
- Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16189514 |
Phenotypes for FAM96B Gene
- GenomeRNAi human phenotypes for FAM96B:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FAM96B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM96B gene
- Search ViGene Biosciences for FAM96B
CRISPR Products
-
OriGene CRISPR knockouts for FAM96B
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM96B
- GenScript: Design CRISPR guide RNA sequences for FAM96B
miRNA for FAM96B Gene
- miRTarBase miRNAs that target FAM96B
miRNA Products
- Search ViGene Biosciences for FAM96B
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FAM96B
- Browse OriGene Inhibitory RNA Products For FAM96B
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM96B gene
Clone Products
-
OriGene ORF clones in human for FAM96B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for FAM96B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FAM96B gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM96B Gene
Localization for FAM96B Gene
Subcellular locations from UniProtKB/Swiss-Prot for FAM96B Gene
- Nucleus. Cytoplasm, cytoskeleton, spindle.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 20797633 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 20797633 |
| GO:0005819 | spindle | IEA,IDA | 20797633 |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for FAM96B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glucose / Energy Metabolism | ||
| 2 | Cytosolic iron-sulfur cluster assembly | ||
| 3 | Metabolism |
.37
|
|
Pathways by source for FAM96B Gene
1 Cell Signaling Technology pathway for FAM96B Gene
2 Reactome pathways for FAM96B Gene
Interacting Proteins for FAM96B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007059 | chromosome segregation | IMP | 20797633 |
| GO:0016226 | iron-sulfur cluster assembly | IBA | -- |
No data available for SIGNOR curated interactions for FAM96B Gene
Transcripts for FAM96B Gene
mRNA/cDNA for FAM96B Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (383) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FAM96B Gene
CRISPR Products
-
OriGene CRISPR knockouts for FAM96B
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM96B
- GenScript: Design CRISPR guide RNA sequences for FAM96B
miRNA Products
- Search ViGene Biosciences for FAM96B
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FAM96B
- Browse OriGene Inhibitory RNA Products For FAM96B
-
ViGene Biosciences ready-to-package AAV shRNAs for FAM96B gene
Clone Products
-
OriGene ORF clones in human for FAM96B
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||
| SP4: | - |
Expression for FAM96B Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM96B Gene
NURSA nuclear receptor signaling pathways regulating expression of FAM96B Gene:
FAM96BSOURCE GeneReport for Unigene cluster for FAM96B Gene:
Hs.9825Evidence on tissue expression from TISSUES for FAM96B Gene
- Liver(4.3)
- Blood(4.2)
- Eye(4.2)
- Nervous system(2.8)
- Pancreas(2.5)
- Muscle(2.1)
Primer Products
-
OriGene qPCR primer pairs for FAM96B
-
OriGene qPCR primer pairs and template standards for FAM96B
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM96B Gene
Orthologs for FAM96B Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FAM96B 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FAM96B 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FAM96B 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fam96b 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fam96b 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FAM96B 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FAM96B 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FAM96B 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fam96b 34 |
|
||
| Str.468 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.10194 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fam96b 34 35 |
|
||
| wufc08f04 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10450 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG7949 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005422 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | F45G2.10 34 35 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AGR343W 34 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F24332g 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CIA2 34 |
|
||
| -- 35 |
|
OneToMany | |||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT1G68310 34 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.2327 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os04g0595200 34 |
|
||
| Os.45029 34 |
|
||||
| barley (Hordeum vulgare) |
Liliopsida | Hv.9354 34 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC144.16 34 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU02573 34 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.2545 34 |
|
- Species where no ortholog for FAM96B was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FAM96B Gene
(1) SIMAP similar genes for FAM96B Gene using alignment to 4 proteins:
Variants for FAM96B Gene
| SNP ID | Clin | Chr 16 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000406021 | -- | 66,935,881(+) | TGGGC(-/TCCTAGAA)TCCTA | intron-variant, nc-transcript-variant, upstream-variant-2KB | |
| rs1000967376 | -- | 66,933,369(+) | TCCAA(A/C)CCCAT | intron-variant, upstream-variant-2KB | |
| rs1002764377 | -- | 66,932,782(+) | TACCT(A/G)CATGC | nc-transcript-variant, upstream-variant-2KB, reference, missense | |
| rs1002905238 | -- | 66,934,168(+) | ATCAC(C/T)GCTCC | intron-variant, nc-transcript-variant, upstream-variant-2KB, splice-acceptor-variant | |
| rs1003225189 | -- | 66,932,478(+) | GAGCC(C/T)ACCTA | intron-variant, upstream-variant-2KB |
Relevant External Links for FAM96B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FAM96B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM96B Gene
Disorders for FAM96B Gene
Relevant External Links for FAM96B
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FAM96B
No disorders were found for FAM96B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM96B Gene
Publications for FAM96B Gene
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 64
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 64
- Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins. (PMID: 23891004) Stehling O. … Lill R. (Cell Metab. 2013) 2 3 64
- MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism. (PMID: 22678361) Gari K. … Boulton S.J. (Science 2012) 3 4 64
- MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PMID: 22678362) Stehling O. … Lill R. (Science 2012) 3 4 64
Products for FAM96B Gene
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- Custom Antibody ServicesOriGene Antibodies for FAM96B
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- OriGene qPCR primer pairs and template standards for FAM96B
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- Cell Signaling Technology (CST) Antibodies for FAM96B (FAM96B)
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- Novus Biologicals Antibodies for FAM96B
- Novus Biologicals proteins and lysates for FAM96B
- Novus Biologicals
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- Abcam antibodies for FAM96B
- Abcam proteins for FAM96B
- Search for Assays for FAM96B at Abcam
- Find your target
- Search knockout validated antibodies
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- antibodies-online Antibodies for FAM96B: See all 38
- Search antibodies-online for kits
- antibodies-online Proteins for FAM96B: See all 4
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- ViGene Biosciences adenoviral particle packaged cDNA for FAM96B gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for FAM96B
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- Santa Cruz Biotechnology (SCBT) CRISPR for FAM96B
- Cyagen custom Knockout/knockin (KOKI) mouse models for FAM96B
- VectorBuilder custom plasmid, inducible vectors for FAM96B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FAM96B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FAM96B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




