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Aliases for FAM96A Gene

Aliases for FAM96A Gene

  • Family With Sequence Similarity 96 Member A 2 3 5
  • Family With Sequence Similarity 96, Member A 2

External Ids for FAM96A Gene

Previous GeneCards Identifiers for FAM96A Gene

  • GC15M062152
  • GC15M064364
  • GC15M041189

Summaries for FAM96A Gene

GeneCards Summary for FAM96A Gene

FAM96A (Family With Sequence Similarity 96 Member A) is a Protein Coding gene. An important paralog of this gene is FAM96B.

UniProtKB/Swiss-Prot for FAM96A Gene

  • May play a role in chromosome segregation through establishment of sister chromatid cohesion.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM96A Gene

Genomics for FAM96A Gene

Regulatory Elements for FAM96A Gene

Enhancers for FAM96A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM96A on UCSC Golden Path with GeneCards custom track

Promoters for FAM96A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM96A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM96A Gene

64,072,559 bp from pter
64,094,018 bp from pter
21,460 bases
Minus strand

Genomic View for FAM96A Gene

Genes around FAM96A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM96A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM96A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM96A Gene

Proteins for FAM96A Gene

  • Protein details for FAM96A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MIP18 family protein FAM96A
    Protein Accession:
    Secondary Accessions:
    • A6NKS1
    • B2R5F8
    • B7Z8Z5

    Protein attributes for FAM96A Gene

    160 amino acids
    Molecular mass:
    18355 Da
    Quaternary structure:
    • Monomer and homodimer. Interacts with CIAO1.

    Three dimensional structures from OCA and Proteopedia for FAM96A Gene

    Alternative splice isoforms for FAM96A Gene


neXtProt entry for FAM96A Gene

Proteomics data for FAM96A Gene at MOPED

Post-translational modifications for FAM96A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM96A Gene

No data available for DME Specific Peptides for FAM96A Gene

Domains & Families for FAM96A Gene

Gene Families for FAM96A Gene

Protein Domains for FAM96A Gene


Suggested Antigen Peptide Sequences for FAM96A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MIP18 family.
  • Belongs to the MIP18 family.
genes like me logo Genes that share domains with FAM96A: view

Function for FAM96A Gene

Molecular function for FAM96A Gene

UniProtKB/Swiss-Prot Function:
May play a role in chromosome segregation through establishment of sister chromatid cohesion.
genes like me logo Genes that share phenotypes with FAM96A: view

Animal Models for FAM96A Gene

MGI Knock Outs for FAM96A:

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM96A

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM96A Gene

Localization for FAM96A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM96A Gene


Subcellular locations from

Jensen Localization Image for FAM96A Gene COMPARTMENTS Subcellular localization image for FAM96A gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for FAM96A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with FAM96A: view

Pathways & Interactions for FAM96A Gene

SuperPathways for FAM96A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM96A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007059 chromosome segregation IBA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with FAM96A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM96A Gene

Drugs & Compounds for FAM96A Gene

No Compound Related Data Available

Transcripts for FAM96A Gene

Unigene Clusters for FAM96A Gene

Family with sequence similarity 96, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM96A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - -
SP2: -
SP3: - - -
SP4: -

Relevant External Links for FAM96A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM96A Gene

mRNA expression in normal human tissues for FAM96A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM96A Gene

This gene is overexpressed in Liver (x5.5).

Protein differential expression in normal tissues from HIPED for FAM96A Gene

This gene is overexpressed in Bone (12.9) and Peripheral blood mononuclear cells (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM96A Gene

SOURCE GeneReport for Unigene cluster for FAM96A Gene Hs.439548

mRNA Expression by UniProt/SwissProt for FAM96A Gene

Tissue specificity: Substantially enriched in macrophages.
genes like me logo Genes that share expression patterns with FAM96A: view

Protein tissue co-expression partners for FAM96A Gene

Primer Products

Orthologs for FAM96A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FAM96A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM96A 35
  • 94.79 (n)
  • 96.87 (a)
FAM96A 36
  • 96 (a)
(Canis familiaris)
Mammalia FAM96A 35
  • 95.21 (n)
  • 96.25 (a)
FAM96A 36
  • 95 (a)
(Mus musculus)
Mammalia Fam96a 35
  • 91.04 (n)
  • 95 (a)
Fam96a 16
Fam96a 36
  • 95 (a)
(Pan troglodytes)
Mammalia FAM96A 35
  • 99.79 (n)
  • 100 (a)
FAM96A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fam96a 35
  • 91.04 (n)
  • 94.37 (a)
(Monodelphis domestica)
Mammalia FAM96A 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia FAM96A 36
  • 91 (a)
(Gallus gallus)
Aves FAM96A 36
  • 64 (a)
(Anolis carolinensis)
Reptilia FAM96A 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489623 35
  • 72.19 (n)
  • 82.78 (a)
Str.16699 35
(Danio rerio)
Actinopterygii wufc15d04 35
zgc:73185 35
  • 71.15 (n)
  • 79.49 (a)
FAM96A 36
  • 93 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007363 35
  • 60.06 (n)
  • 61.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30152 35
  • 57.58 (n)
  • 61.36 (a)
CG30152 36
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 27 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G50845 35
  • 60.06 (n)
  • 56.03 (a)
(Oryza sativa)
Liliopsida Os03g0775500 35
  • 54.82 (n)
  • 53.72 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7628 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
Species with no ortholog for FAM96A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM96A Gene

Gene Tree for FAM96A (if available)
Gene Tree for FAM96A (if available)

Paralogs for FAM96A Gene

Paralogs for FAM96A Gene

(10) SIMAP similar genes for FAM96A Gene using alignment to 3 proteins: Pseudogenes for FAM96A Gene

genes like me logo Genes that share paralogs with FAM96A: view

Variants for FAM96A Gene

Sequence variations from dbSNP and Humsavar for FAM96A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs332232 -- 64,074,308(+) AATTT(A/G)GTTTC intron-variant, utr-variant-3-prime
rs332233 -- 64,075,546(+) GAAAG(C/T)GGGAA intron-variant
rs332234 -- 64,075,576(+) ATTAA(C/T)GCATT intron-variant
rs332260 -- 64,091,001(+) AATAA(A/G)GAGAA intron-variant
rs332261 -- 64,090,830(+) TAAGG(A/G)CAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM96A Gene

Variant ID Type Subtype PubMed ID
nsv1569 CNV Loss 18451855
nsv833036 CNV Loss 17160897
esv2667267 CNV Deletion 23128226

Variation tolerance for FAM96A Gene

Residual Variation Intolerance Score: 36.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.44% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAM96A Gene

Disorders for FAM96A Gene

Relevant External Links for FAM96A

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM96A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM96A Gene

Publications for FAM96A Gene

  1. FAM96A is a novel pro-apoptotic tumor suppressor in gastrointestinal stromal tumors. (PMID: 25716227) Schwamb B. … ZAPrnig M. (Int. J. Cancer 2015) 2 3 67
  2. Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins. (PMID: 23891004) Stehling O. … Lill R. (Cell Metab. 2013) 2 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. The mammalian DUF59 protein Fam96a forms two distinct types of domain-swapped dimer. (PMID: 22683786) Chen K.E. … Martin J.L. (Acta Crystallogr. D 2012) 3

Products for FAM96A Gene

Sources for FAM96A Gene