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Aliases for FAM96A Gene

Aliases for FAM96A Gene

  • Family With Sequence Similarity 96 Member A 2 3 5
  • Family With Sequence Similarity 96, Member A 2
  • MIP18 Family Protein FAM96A 3
  • CIA2A 3

External Ids for FAM96A Gene

Previous GeneCards Identifiers for FAM96A Gene

  • GC15M062152
  • GC15M064364
  • GC15M041189

Summaries for FAM96A Gene

GeneCards Summary for FAM96A Gene

FAM96A (Family With Sequence Similarity 96 Member A) is a Protein Coding gene. An important paralog of this gene is FAM96B.

UniProtKB/Swiss-Prot for FAM96A Gene

  • May play a role in chromosome segregation through establishment of sister chromatid cohesion.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM96A Gene

Genomics for FAM96A Gene

Regulatory Elements for FAM96A Gene

Enhancers for FAM96A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G064069 1.5 Ensembl ENCODE dbSUPER 19 +22.6 22586 4.1 HNRNPUL1 FOXA2 MLX ARID4B YY1 SLC30A9 ZNF766 ZNF143 FOS SP5 TRIP4 SNX1 FAM96A SNX22 ENSG00000265967 ZNF609 HERC1 ENSG00000264937 PPIB FBXL22
GH15G064104 1.6 FANTOM5 Ensembl ENCODE dbSUPER 8.2 -11.4 -11384 1.2 PKNOX1 FOXA2 MAX CEBPG YY1 ZNF316 ADNP NFE2 MAFK BHLHE40 SNX22 PPIB DAPK2 FBXL22 ENSG00000252774 FAM96A SNX1 GC15M064112 ENSG00000201071
GH15G064092 1.5 ENCODE dbSUPER 8.1 -1.4 -1409 6.5 CREB3L1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TRIP4 ZNF609 SNX22 SPG21 DAPK2 HERC1 SNX1 USP3 FAM96A GC15M064112
GH15G064088 1.3 ENCODE dbSUPER 8.3 +3.6 3596 3.1 PKNOX1 ATF1 E2F7 ARID4B SIN3A DMAP1 ZNF48 GLIS2 ELK1 FOS TRIP4 SNX22 ZNF609 FAM96A SNX1 DAPK2
GH15G064115 0.9 dbSUPER 11.8 -31.4 -31368 20.3 FOXA2 NFIB FEZF1 BMI1 NFXL1 RAD21 YY1 ZNF121 RELB IKZF2 TRIP4 SNX22 SNX1 DAPK2 PPIB FAM96A ENSG00000252774 SPG21 GC15M064112 ENSG00000201071
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM96A on UCSC Golden Path with GeneCards custom track

Promoters for FAM96A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000077898 318 1801 HDGF PKNOX1 FOXA2 CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766

Genomic Location for FAM96A Gene

Chromosome:
15
Start:
64,072,559 bp from pter
End:
64,094,018 bp from pter
Size:
21,460 bases
Orientation:
Minus strand

Genomic View for FAM96A Gene

Genes around FAM96A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM96A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM96A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM96A Gene

Proteins for FAM96A Gene

  • Protein details for FAM96A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H5X1-FA96A_HUMAN
    Recommended name:
    MIP18 family protein FAM96A
    Protein Accession:
    Q9H5X1
    Secondary Accessions:
    • A6NKS1
    • B2R5F8
    • B7Z8Z5

    Protein attributes for FAM96A Gene

    Size:
    160 amino acids
    Molecular mass:
    18355 Da
    Quaternary structure:
    • Monomer and homodimer. Interacts with CIAO1.

    Three dimensional structures from OCA and Proteopedia for FAM96A Gene

    Alternative splice isoforms for FAM96A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM96A Gene

Post-translational modifications for FAM96A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM96A Gene

No data available for DME Specific Peptides for FAM96A Gene

Domains & Families for FAM96A Gene

Gene Families for FAM96A Gene

Protein Domains for FAM96A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM96A Gene

Graphical View of Domain Structure for InterPro Entry

Q9H5X1

UniProtKB/Swiss-Prot:

FA96A_HUMAN :
  • Belongs to the MIP18 family.
Family:
  • Belongs to the MIP18 family.
genes like me logo Genes that share domains with FAM96A: view

Function for FAM96A Gene

Molecular function for FAM96A Gene

UniProtKB/Swiss-Prot Function:
May play a role in chromosome segregation through establishment of sister chromatid cohesion.

Gene Ontology (GO) - Molecular Function for FAM96A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FAM96A: view
genes like me logo Genes that share phenotypes with FAM96A: view

Animal Models for FAM96A Gene

MGI Knock Outs for FAM96A:

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM96A

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM96A Gene

Localization for FAM96A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM96A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM96A gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for FAM96A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with FAM96A: view

Pathways & Interactions for FAM96A Gene

SuperPathways for FAM96A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM96A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007059 chromosome segregation IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with FAM96A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM96A Gene

Transcripts for FAM96A Gene

Unigene Clusters for FAM96A Gene

Family with sequence similarity 96, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM96A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - -
SP2: -
SP3: - - -
SP4: -

Relevant External Links for FAM96A Gene

GeneLoc Exon Structure for
FAM96A
ECgene alternative splicing isoforms for
FAM96A

Expression for FAM96A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM96A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM96A Gene

This gene is overexpressed in Liver (x5.5).

Protein differential expression in normal tissues from HIPED for FAM96A Gene

This gene is overexpressed in Bone (12.9) and Peripheral blood mononuclear cells (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM96A Gene



Protein tissue co-expression partners for FAM96A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM96A Gene:

FAM96A

SOURCE GeneReport for Unigene cluster for FAM96A Gene:

Hs.439548

mRNA Expression by UniProt/SwissProt for FAM96A Gene:

Q9H5X1-FA96A_HUMAN
Tissue specificity: Substantially enriched in macrophages.

Evidence on tissue expression from TISSUES for FAM96A Gene

  • Nervous system(4.5)
  • Liver(2)
genes like me logo Genes that share expression patterns with FAM96A: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM96A Gene

Orthologs for FAM96A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FAM96A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM96A 34 35
  • 99.79 (n)
dog
(Canis familiaris)
Mammalia FAM96A 34 35
  • 95.21 (n)
cow
(Bos Taurus)
Mammalia FAM96A 34 35
  • 94.79 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM96A 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam96a 34 16 35
  • 91.04 (n)
rat
(Rattus norvegicus)
Mammalia Fam96a 34
  • 91.04 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM96A 35
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM96A 35
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM96A 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489623 34
  • 72.19 (n)
Str.16699 34
zebrafish
(Danio rerio)
Actinopterygii FAM96A 35
  • 93 (a)
OneToOne
zgc:73185 34
  • 71.15 (n)
wufc15d04 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007363 34
  • 60.06 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG30152 34 35
  • 57.58 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 27 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G50845 34
  • 60.06 (n)
rice
(Oryza sativa)
Liliopsida Os03g0775500 34
  • 54.82 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 55 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7628 34
Species where no ortholog for FAM96A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM96A Gene

ENSEMBL:
Gene Tree for FAM96A (if available)
TreeFam:
Gene Tree for FAM96A (if available)

Paralogs for FAM96A Gene

Paralogs for FAM96A Gene

(10) SIMAP similar genes for FAM96A Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for FAM96A Gene

genes like me logo Genes that share paralogs with FAM96A: view

Variants for FAM96A Gene

Sequence variations from dbSNP and Humsavar for FAM96A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000007428 -- 64,091,126(+) AACTG(A/G)GAAAA intron-variant
rs1000038584 -- 64,090,860(+) ATATA(A/G)GTTGG intron-variant
rs1000061445 -- 64,083,642(+) ATACA(A/G)TTCTC intron-variant
rs1000113486 -- 64,083,461(+) GAGTC(C/T)TCCTT intron-variant
rs1000113517 -- 64,090,603(+) TAAAT(C/G)CTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM96A Gene

Variant ID Type Subtype PubMed ID
esv2667267 CNV deletion 23128226
nsv1122974 CNV deletion 24896259
nsv1131193 CNV deletion 24896259
nsv1569 CNV deletion 18451855
nsv833036 CNV loss 17160897

Variation tolerance for FAM96A Gene

Residual Variation Intolerance Score: 36.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM96A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM96A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM96A Gene

Disorders for FAM96A Gene

Relevant External Links for FAM96A

Genetic Association Database (GAD)
FAM96A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM96A

No disorders were found for FAM96A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM96A Gene

Publications for FAM96A Gene

  1. FAM96A is a novel pro-apoptotic tumor suppressor in gastrointestinal stromal tumors. (PMID: 25716227) Schwamb B. … ZAPrnig M. (Int. J. Cancer 2015) 2 3 64
  2. Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins. (PMID: 23891004) Stehling O. … Lill R. (Cell Metab. 2013) 2 3 64
  3. The mammalian DUF59 protein Fam96a forms two distinct types of domain-swapped dimer. (PMID: 22683786) Chen K.E. … Martin J.L. (Acta Crystallogr. D 2012) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for FAM96A Gene

Sources for FAM96A Gene

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