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Aliases for FAM96A Gene

Aliases for FAM96A Gene

  • Family With Sequence Similarity 96, Member A 2 3

External Ids for FAM96A Gene

Previous GeneCards Identifiers for FAM96A Gene

  • GC15M062152
  • GC15M064364
  • GC15M041189

Summaries for FAM96A Gene

GeneCards Summary for FAM96A Gene

FAM96A (Family With Sequence Similarity 96, Member A) is a Protein Coding gene. An important paralog of this gene is FAM96B.

UniProtKB/Swiss-Prot for FAM96A Gene

  • May play a role in chromosome segregation through establishment of sister chromatid cohesion.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM96A Gene

Genomics for FAM96A Gene

Regulatory Elements for FAM96A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM96A Gene

64,072,559 bp from pter
64,094,018 bp from pter
21,460 bases
Minus strand

Genomic View for FAM96A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM96A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM96A Gene

Proteins for FAM96A Gene

  • Protein details for FAM96A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MIP18 family protein FAM96A
    Protein Accession:
    Secondary Accessions:
    • A6NKS1
    • B2R5F8
    • B7Z8Z5

    Protein attributes for FAM96A Gene

    160 amino acids
    Molecular mass:
    18355 Da
    Quaternary structure:
    • Monomer and homodimer. Interacts with CIAO1.

    Three dimensional structures from OCA and Proteopedia for FAM96A Gene

    Alternative splice isoforms for FAM96A Gene


neXtProt entry for FAM96A Gene

Proteomics data for FAM96A Gene at MOPED

Post-translational modifications for FAM96A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM96A Gene

Antibody Products

No data available for DME Specific Peptides for FAM96A Gene

Domains for FAM96A Gene

Gene Families for FAM96A Gene

Protein Domains for FAM96A Gene


Suggested Antigen Peptide Sequences for FAM96A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MIP18 family.
  • Belongs to the MIP18 family.
genes like me logo Genes that share domains with FAM96A: view

Function for FAM96A Gene

Molecular function for FAM96A Gene

UniProtKB/Swiss-Prot Function:
May play a role in chromosome segregation through establishment of sister chromatid cohesion.

Gene Ontology (GO) - Molecular Function for FAM96A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FAM96A: view

Animal Model Products

CRISPR Products

miRNA for FAM96A Gene

miRTarBase miRNAs that target FAM96A

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM96A Gene

Localization for FAM96A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM96A Gene


Subcellular locations from

Jensen Localization Image for FAM96A Gene COMPARTMENTS Subcellular localization image for FAM96A gene
Compartment Confidence
extracellular 2
mitochondrion 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FAM96A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with FAM96A: view

Pathways for FAM96A Gene

SuperPathways for FAM96A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM96A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007059 chromosome segregation IBA --
GO:0008150 biological_process ND --
GO:0016226 iron-sulfur cluster assembly IBA --
genes like me logo Genes that share ontologies with FAM96A: view

No data available for Pathways by source for FAM96A Gene

Transcripts for FAM96A Gene

Unigene Clusters for FAM96A Gene

Family with sequence similarity 96, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM96A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM96A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - -
SP2: -
SP3: - - -
SP4: -

Relevant External Links for FAM96A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM96A Gene

mRNA expression in normal human tissues for FAM96A Gene

mRNA differential expression in normal tissues according to GTEx for FAM96A Gene

This gene is overexpressed in Liver (5.5).

Protein differential expression in normal tissues for FAM96A Gene

This gene is overexpressed in Bone (12.9) and Peripheral blood mononuclear cells (11.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM96A Gene

SOURCE GeneReport for Unigene cluster for FAM96A Gene Hs.439548

mRNA Expression by UniProt/SwissProt for FAM96A Gene

Tissue specificity: Substantially enriched in macrophages.
genes like me logo Genes that share expressions with FAM96A: view

Expression partners for FAM96A Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FAM96A Gene

Orthologs for FAM96A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FAM96A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM96A 35
  • 94.79 (n)
  • 96.87 (a)
FAM96A 36
  • 96 (a)
(Canis familiaris)
Mammalia FAM96A 35
  • 95.21 (n)
  • 96.25 (a)
FAM96A 36
  • 95 (a)
(Mus musculus)
Mammalia Fam96a 35
  • 91.04 (n)
  • 95 (a)
Fam96a 16
Fam96a 36
  • 95 (a)
(Pan troglodytes)
Mammalia FAM96A 35
  • 99.79 (n)
  • 100 (a)
FAM96A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fam96a 35
  • 91.04 (n)
  • 94.37 (a)
(Monodelphis domestica)
Mammalia FAM96A 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia FAM96A 36
  • 91 (a)
(Gallus gallus)
Aves FAM96A 36
  • 64 (a)
(Anolis carolinensis)
Reptilia FAM96A 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489623 35
  • 72.19 (n)
  • 82.78 (a)
Str.16699 35
(Danio rerio)
Actinopterygii wufc15d04 35
zgc:73185 35
  • 71.15 (n)
  • 79.49 (a)
FAM96A 36
  • 93 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007363 35
  • 60.06 (n)
  • 61.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30152 35
  • 57.58 (n)
  • 61.36 (a)
CG30152 36
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 27 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G50845 35
  • 60.06 (n)
  • 56.03 (a)
(Oryza sativa)
Liliopsida Os03g0775500 35
  • 54.82 (n)
  • 53.72 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7628 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
Species with no ortholog for FAM96A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM96A Gene

Gene Tree for FAM96A (if available)
Gene Tree for FAM96A (if available)

Paralogs for FAM96A Gene

Paralogs for FAM96A Gene

(10) SIMAP similar genes for FAM96A Gene using alignment to 3 proteins: Pseudogenes for FAM96A Gene

genes like me logo Genes that share paralogs with FAM96A: view

Variants for FAM96A Gene

Sequence variations from dbSNP and Humsavar for FAM96A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs332232 -- 64,074,308(+) AATTT(A/G)GTTTC intron-variant, utr-variant-3-prime
rs332233 -- 64,075,546(+) GAAAG(C/T)GGGAA intron-variant
rs332234 -- 64,075,576(+) ATTAA(C/T)GCATT intron-variant
rs332260 -- 64,091,001(+) AATAA(A/G)GAGAA intron-variant
rs332261 -- 64,090,830(+) TAAGG(A/G)CAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM96A Gene

Variant ID Type Subtype PubMed ID
nsv1569 CNV Loss 18451855
nsv833036 CNV Loss 17160897
esv2667267 CNV Deletion 23128226

Relevant External Links for FAM96A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM96A Gene

Disorders for FAM96A Gene

Relevant External Links for FAM96A

Genetic Association Database (GAD)

No disorders were found for FAM96A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for FAM96A Gene

Publications for FAM96A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. FAM96A is a novel pro-apoptotic tumor suppressor in gastrointestinal stromal tumors. (PMID: 25716227) Schwamb B. … ZAPrnig M. (Int. J. Cancer 2015) 2 3
  4. The mammalian DUF59 protein Fam96a forms two distinct types of domain-swapped dimer. (PMID: 22683786) Chen K.E. … Martin J.L. (Acta Crystallogr. D 2012) 3 4
  5. Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins. (PMID: 23891004) Stehling O. … Lill R. (Cell Metab. 2013) 2 3

Products for FAM96A Gene

Sources for FAM96A Gene

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