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FAM92B Gene

protein-coding   GIFtS: 42
GCID: GC16M085131          (predicted)

Family With Sequence Similarity 92, Member B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 92, Member B1 2
Protein FAM92B2

External Ids:    HGNC: 247811   Entrez Gene: 3391452   Ensembl: ENSG000001537897   UniProtKB: Q6ZTR73   

Export aliases for FAM92B gene to outside databases

Previous GC identifers: GC16M083690 GC16M070884


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM92B Gene:
FAM92B (family with sequence similarity 92, member B) is a protein-coding gene. An important paralog of this gene is FAM92A1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM92B gene promoter:
         AhR   LHX3b/Lhx3b   NF-1   Brachyury   HTF   Roaz   Egr-2   AREB6   FOXO4   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM92B promoter sequence
   Search Chromatin IP Primers for FAM92B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM92B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.1   Ensembl cytogenetic band:  16q24.1   HGNC cytogenetic band: 16q24.1

FAM92B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM92B gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M085131:  view genomic region     (about GC identifiers)

Start:
85,131,965 bp from pter      End:
85,146,114 bp from pter
Size:
14,150 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FA92B_HUMAN, Q6ZTR7 (See protein sequence)
Recommended Name: Protein FAM92B  
Size: 304 amino acids; 34785 Da

Explore the universe of human proteins at neXtProt for FAM92B: NX_Q6ZTR7

Explore proteomics data for FAM92B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM92B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_940893.1  
    ENSEMBL proteins: 
     ENSP00000443411  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR027267 AH/BAR-dom
     IPR009602 FAM92

    Graphical View of Domain Structure for InterPro Entry Q6ZTR7

    ProtoNet protein and cluster: Q6ZTR7

    UniProtKB/Swiss-Prot: FA92B_HUMAN, Q6ZTR7
    Similarity: Belongs to the FAM92 family


    Find genes that share domains with FAM92B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM92B
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM92B
    Interactions:

        Search GeneGlobe Interaction Network for FAM92B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM92B (FA92B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM92B gene: 
    NM_198491.1  

    Unigene Cluster for FAM92B:

    Family with sequence similarity 92, member B
    Hs.125713  [show with all ESTs]
    Unigene Representative Sequence: AK126284
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000539556(uc021tlz.1 uc021tma.1)
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    SwitchGear 3'UTR luciferase reporter plasmidFAM92B 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat FAM92B

    Additional mRNA sequence: 

    AK126284.1 BC093665.1 BC111944.1 

    3 DOTS entries:

    DT.99975300  DT.300311  DT.120691278 

    9 AceView cDNA sequences:

    AA885104 BU685247 CA438550 AI672213 AK126284 AI935262 NM_198491 BU680724 
    AW009602 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM92B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGAGGCCC
    FAM92B Expression
    About this image

    FAM92B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM92B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.125713
        Custom PCR Arrays for FAM92B
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FAM92B gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam92b1 , 5 family with sequence similarity 92, member B1, 5 83.07(n)1
    80.16(a)1
      8 (69.09 cM)5
    4360621  NM_001033980.21  NP_001029152.21 
     1201663975 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.125672 Xenopus laevis transcribed sequences 75.14(n)    BJ070674.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG64056
    --
    17(a)
    1 → many
    2L(12424904-12426440)


    ENSEMBL Gene Tree for FAM92B (if available)
    TreeFam Gene Tree for FAM92B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM92B gene
    FAM92A12  
    1 SIMAP similar gene for FAM92B using alignment to 2 protein entries:     FA92B_HUMAN (see all proteins):
    FAM92A1

    Find genes that share paralogs with FAM92B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM92B (see all 588)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1178945501,2
    F--85131579(+) TGGGCG/ATCCTT 1 -- ds50011Minor allele frequency- A:0.01EA 120
    rs1471039741,2
    --85131589(+) TTATAA/GGAGGG 1 -- ds50010--------
    rs1385444381,2
    --85131659(+) AGGTCC/TGGGGG 1 -- ds50010--------
    rs1894065461,2
    --85131660(+) GGTCCA/GGGGGA 1 -- ds50010--------
    rs1809835761,2
    --85131665(+) GGGGGA/TTGTGG 1 -- ds50010--------
    rs1860830331,2
    --85131687(+) GGCGTA/GCCAAG 1 -- ds50010--------
    rs1913524911,2
    --85131729(+) GGGATC/GGGTGC 1 -- ds50010--------
    rs1419328661,2
    C--85131781(+) TGCTCA/GCAGAT 1 -- ds50010--------
    rs1457857151,2
    --85131784(+) TCGCAG/TATTTC 1 -- ds50010--------
    rs1833137161,2
    --85131845(+) CAGTGA/GTGCTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for FAM92B (85131965 - 85146114 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for FAM92B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv907090CNV Loss21882294
    nsv907087CNV Loss21882294
    nsv907089CNV Loss21882294
    dgv2936n71CNV Loss21882294
    nsv907092CNV Loss21882294
    nsv907091CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease from the University of Copenhagen DISEASES database for FAM92B:
    Crohn's disease

    Find genes that share disorders with FAM92B           About GenesLikeMe

    Genetic Association Database (GAD): FAM92B
    Human Genome Epidemiology (HuGE) Navigator: FAM92B (3 documents)

    Export disorders for FAM92B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM92B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM92B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. rs224136 on chromosome 10q21.1 and variants in PHOX2B, NCF4, and FAM92B are not major genetic risk factors for susceptibility to Crohn's disease in the German population. (PubMed id 19262523)1, 4 Glas J....Brand S. (Am. J. Gastroenterol. 2009)
    2. Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort. (PubMed id 18580884)1, 4 Roberts R.L....Merriman T.R. (Genes Immun. 2008)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. NELL1, NCF4, and FAM92B genes are not major susceptibility genes for Crohn's disease in Canadian children and young adults. (PubMed id 21472827)1 Amre D.K....Levy E. (Inflamm. Bowel Dis. 2012)
    5. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. (PubMed id 17068223)4 Duerr R.H.... Cho J.H. (Science 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 339145 HGNC: 24781 AceView: FLJ44299 Ensembl:ENSG00000153789 euGenes: HUgn339145
    ECgene: FAM92B H-InvDB: FAM92B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM92B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM92B gene:
    Search GeneIP for patents involving FAM92B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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