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Aliases for FAM92B Gene

Aliases for FAM92B Gene

  • Family With Sequence Similarity 92 Member B 2 3 5
  • Family With Sequence Similarity 92, Member B 2

External Ids for FAM92B Gene

Previous GeneCards Identifiers for FAM92B Gene

  • GC16M083690
  • GC16M085131
  • GC16M070884

Summaries for FAM92B Gene

GeneCards Summary for FAM92B Gene

FAM92B (Family With Sequence Similarity 92 Member B) is a Protein Coding gene. An important paralog of this gene is FAM92A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM92B Gene

Genomics for FAM92B Gene

Regulatory Elements for FAM92B Gene

Enhancers for FAM92B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F085166 1.8 FANTOM5 Ensembl ENCODE 10 -59.6 -59616 10.6 PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 KIAA0513 FAM92B GSE1 PIR50782
GH16F085150 1.5 FANTOM5 Ensembl ENCODE 11.2 -40.0 -39983 3.8 SIN3A KLF17 ZNF48 RAD21 RARA ZNF121 GLIS2 ZNF366 FOS EGR2 ZDHHC7 ENSG00000270184 ENSG00000261243 FAM92B RNU1-103P ENSG00000275088 LOC105371382
GH16F085123 1.3 Ensembl ENCODE 10.9 -13.1 -13059 4.5 HDGF PKNOX1 MLX CREB3L1 ZFP64 ARID4B DMAP1 YBX1 SLC30A9 ZNF766 CRISPLD2 FAM92B ENSG00000261243 LOC105371381 LOC400548
GH16F085157 1.3 Ensembl ENCODE 9.3 -46.9 -46871 4.4 HDGF PKNOX1 MLX ZFP64 ARID4B YBX1 DMAP1 ZNF48 ETS1 ZNF143 CRISPLD2 ENSG00000261243 FAM92B LOC105371382 ENSG00000275088
GH16F085161 1.3 FANTOM5 Ensembl ENCODE 7.9 -50.3 -50260 1.6 BCOR TFAP4 ZNF792 SIN3A ARID4B ZMYM3 CEBPG RAD21 FOS ZNF600 KIAA0513 FAM92B LOC105371382 ENSG00000275088
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM92B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM92B Gene

Chromosome:
16
Start:
85,098,352 bp from pter
End:
85,112,508 bp from pter
Size:
14,157 bases
Orientation:
Minus strand

Genomic View for FAM92B Gene

Genes around FAM92B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM92B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM92B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM92B Gene

Proteins for FAM92B Gene

  • Protein details for FAM92B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZTR7-FA92B_HUMAN
    Recommended name:
    Protein FAM92B
    Protein Accession:
    Q6ZTR7

    Protein attributes for FAM92B Gene

    Size:
    304 amino acids
    Molecular mass:
    34785 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM92B Gene

Post-translational modifications for FAM92B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM92B Gene

No data available for DME Specific Peptides for FAM92B Gene

Domains & Families for FAM92B Gene

Protein Domains for FAM92B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM92B Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZTR7

UniProtKB/Swiss-Prot:

FA92B_HUMAN :
  • Belongs to the FAM92 family.
Family:
  • Belongs to the FAM92 family.
genes like me logo Genes that share domains with FAM92B: view

No data available for Gene Families for FAM92B Gene

Function for FAM92B Gene

genes like me logo Genes that share phenotypes with FAM92B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM92B Gene

Localization for FAM92B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM92B gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM92B Gene

Pathways & Interactions for FAM92B Gene

SuperPathways for FAM92B Gene

No Data Available

Interacting Proteins for FAM92B Gene

Gene Ontology (GO) - Biological Process for FAM92B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM92B Gene

Transcripts for FAM92B Gene

mRNA/cDNA for FAM92B Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM92B Gene

Family with sequence similarity 92, member B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM92B Gene

No ASD Table

Relevant External Links for FAM92B Gene

GeneLoc Exon Structure for
FAM92B
ECgene alternative splicing isoforms for
FAM92B

Expression for FAM92B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM92B Gene

mRNA differential expression in normal tissues according to GTEx for FAM92B Gene

This gene is overexpressed in Pituitary (x12.9), Fallopian Tube (x8.1), Brain - Hypothalamus (x5.8), Lung (x4.8), and Cervix - Endocervix (x4.5).

Protein differential expression in normal tissues from HIPED for FAM92B Gene

This gene is overexpressed in Frontal cortex (18.3), Bone marrow mesenchymal stem cell (9.5), and Urinary Bladder (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM92B Gene



Protein tissue co-expression partners for FAM92B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM92B Gene:

FAM92B

SOURCE GeneReport for Unigene cluster for FAM92B Gene:

Hs.125713
genes like me logo Genes that share expression patterns with FAM92B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAM92B Gene

Orthologs for FAM92B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM92B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM92B 34 35
  • 98.9 (n)
mouse
(Mus musculus)
Mammalia Fam92b 34 16 35
  • 83.07 (n)
cow
(Bos Taurus)
Mammalia FAM92B 34 35
  • 81.76 (n)
rat
(Rattus norvegicus)
Mammalia Fam92b 34
  • 80.82 (n)
dog
(Canis familiaris)
Mammalia FAM92B 34 35
  • 79.98 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM92B 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM92B 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam92b 34
  • 64.96 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12567 34
fruit fly
(Drosophila melanogaster)
Insecta CG6405 35
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11121 35
  • 29 (a)
OneToMany
Species where no ortholog for FAM92B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM92B Gene

ENSEMBL:
Gene Tree for FAM92B (if available)
TreeFam:
Gene Tree for FAM92B (if available)

Paralogs for FAM92B Gene

Paralogs for FAM92B Gene

(1) SIMAP similar genes for FAM92B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM92B: view

Variants for FAM92B Gene

Sequence variations from dbSNP and Humsavar for FAM92B Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1010639 -- 85,098,251(-) GCTGC(C/G)TTGAC downstream-variant-500B
rs111226199 -- 85,111,102(+) GGAGG(C/G)CTGGC intron-variant
rs111232162 -- 85,106,797(+) CAATC(C/G)TGAGC intron-variant
rs111234663 -- 85,101,828(+) CCACG(A/C)CTGGC intron-variant
rs111337621 -- 85,108,156(+) CAGCC(C/T)GGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM92B Gene

Variant ID Type Subtype PubMed ID
dgv3059n100 CNV gain 25217958
nsv1066002 CNV loss 25217958
nsv1066260 CNV gain 25217958
nsv483044 CNV gain 15286789
nsv573474 CNV loss 21841781

Variation tolerance for FAM92B Gene

Residual Variation Intolerance Score: 79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.65; 56.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM92B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM92B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM92B Gene

Disorders for FAM92B Gene

Relevant External Links for FAM92B

Genetic Association Database (GAD)
FAM92B
Human Genome Epidemiology (HuGE) Navigator
FAM92B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM92B

No disorders were found for FAM92B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM92B Gene

Publications for FAM92B Gene

  1. BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis. (PMID: 27528616) Li F.Q. … Takemaru K.I. (Mol. Cell. Biol. 2016) 2 3 64
  2. rs224136 on chromosome 10q21.1 and variants in PHOX2B, NCF4, and FAM92B are not major genetic risk factors for susceptibility to Crohn's disease in the German population. (PMID: 19262523) Glas J. … Brand S. (Am. J. Gastroenterol. 2009) 3 46 64
  3. Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort. (PMID: 18580884) Roberts R.L. … Merriman T.R. (Genes Immun. 2008) 3 46 64
  4. NELL1, NCF4, and FAM92B genes are not major susceptibility genes for Crohn's disease in Canadian children and young adults. (PMID: 21472827) Amre D.K. … Levy E. (Inflamm. Bowel Dis. 2012) 3 64
  5. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. (PMID: 17068223) Duerr R.H. … Cho J.H. (Science 2006) 46 64

Products for FAM92B Gene

Sources for FAM92B Gene

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